Diseases of the skin
Transcript of Diseases of the skin
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SKINSKIN
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SkinSkin, epidermisSkin, epidermis, keratinocytes, stratum basale (germinativum) Skin, epidermis, keratinocytes, stratum spinosum (prickle cells)Skin, epidermis, keratinocytes, stratum granulosumSkin, epidermis, keratinocytes, stratum lucidumSkin, epidermis, keratinocytes, stratum corneum, thin skinSkin, epidermis, keratinocytes, stratum corneum, thick skinSkin, epidermis, melanocytesSkin, epidermis, Langerhans cellsSkin, epidermis, Merkel cellsSkin, epidermis, appendage(s)Skin, epidermis, appendage, hair follicleSkin, epidermis, appendage, hair follicle, shaftSkin, epidermis, appendage, hair follicle, sebaceous glandSkin, epidermis, appendage, sweat gland, eccrineSkin, epidermis, appendage, sweat gland, apocrineSkin, basement membraneSkin, dermisSkin, dermis, papillarySkin, dermis, reticularSkin, hypodermis (sub-cutis, pannus)
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MacroscopicMacroscopic, maculeMacroscopic, patchMacroscopic, papuleMacroscopic, noduleMacroscopic, plaqueMacroscopic, vesicleMacroscopic, bullaMacroscopic, blisterMacroscopic, pustuleMacroscopic, whealMacroscopic, scaleMacroscopic, lichenificationMacroscopic, excoriationMacroscopic, onycholysismicroscopicmicroscopic, hyperkeratosismicroscopic, parakeratosismicroscopic, hypergranulosismicroscopic, acanthosismicroscopic, papillomatosismicroscopic, acantholysismicroscopic, spongiosismicroscopic, hydropic swelling (ballooning)microscopic, exocytosismicroscopic, erosionmicroscopic, ulcerationmicroscopic, vacuolizationmicroscopic, lentiginous
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Pigmentation disordersPigmentation disorders, vitiligoPigmentation disorders, freckle (ephelis)Pigmentation disorders, melasmaPigmentation disorders, lentigoPigmentation disorders, nevusPigmentation disorders, nevus, melanocyticPigmentation disorders, nevus, dysplasticPigmentation disorders, malignant melanomaEpidermal neoplasmsEpidermal neoplasms, benignEpidermal neoplasms, benign, seborrheic keratosisEpidermal neoplasms, benign, acanthosis nigricansEpidermal neoplasms, benign, fibroepithelial polyp (skin tag)Epidermal neoplasms, benign, epithelial inclusion cyst (wen)Epidermal neoplasms, benign, appendage tumorsEpidermal neoplasms, benign, keratoacanthomaEpidermal neoplasms, malignant, actinic keratosisEpidermal neoplasms, malignant, squamous cell carcinoma (SCC)Epidermal neoplasms, malignant, basal cell carcinoma (BCC)Epidermal neoplasms, malignant, Merkel cell tumorDermal neoplasmsDermal neoplasms, fibrous histiocytoma (dermatofibroma)Dermal neoplasms, dermatofibrosarcoma protuberansDermal neoplasms, xanthomasDermal neoplasms, vascular tumorsTumors of cellular “immigrants”, Langerhans cellsTumors of cellular “immigrants”, t- cell lymphomas (Mycosis Fungoides)Tumors of cellular “immigrants”, mast cells
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Epidermis, maturation disorder, ichthyosisEpidermis/Dermis, inflammation, acuteEpidermis/Dermis, inflammation, acute, urticariaEpidermis/Dermis, inflammation, acute, eczemaEpidermis/Dermis, inflammation, acute, erythema multiformeEpidermis/Dermis, inflammation, chronicEpidermis/Dermis, inflammation, chronic, psoriasisEpidermis/Dermis, inflammation, chronic, seborrheic dermatitisEpidermis/Dermis, inflammation, chronic, lichen planusEpidermis/Dermis, inflammation, chronic, lupus erythematosusEpidermis/Dermis, infection/infestationEpidermis/Dermis, infection/infestation, (verrucae)Epidermis/Dermis, infection/infestation, molluscum contagiosumEpidermis/Dermis, infection/infestation, impetigoEpidermis/Dermis, infection/infestation, fungusEpidermis/Dermis, infection/infestation, arthropodsEpidermis/Dermis, infection/infestation, arthropods, bitesEpidermis/Dermis, infection/infestation, arthropods, stingsEpidermis/Dermis, infection/infestation, arthropods, infestationsEpidermis/Dermis, bullae (blisters)Epidermis/Dermis, bullae, pemphigusEpidermis/Dermis, bullae, bullous pemphigoidEpidermis/Dermis, bullae, dermatitis herpetiformisEpidermis/Dermis, bullae, epidermolysis bullosaEpidermis/Dermis, bullae, porphyriaEpidermis/Dermis, adnexae (appendages), acne vulgarisHypodermis (pannus), inflammation (panniculitis)Hypodermis (pannus), inflammation, erythema nodosumHypodermis (pannus), inflammation, erythema induratum
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NORMAL SKINwww.freelivedoctor.com
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NORMAL SKIN, with labelswww.freelivedoctor.com
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MACRO-scopic (clinical)TERMS
• macule• patch• papule• nodule• plaque• vesicle• bulla• blister• pustule• wheal• scale• lichenification• excoriation• onycholysis www.freelivedoctor.com
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MACROSCOPIC TERMSMacule: Circumscribed lesion of up to 5 mm in diameter characterized by flatness and usually discolored (often red)Patch: Circumscribed lesion of more than 5 mm in diameter characterized by flatness and usually discolored (often red) Papule: Elevated dome-shaped or flat-topped lesion 5 mm or less across. Nodule: Elevated lesion with spherical contour greater than 5 mm across. Plaque: Elevated flat-topped lesion, usually greater than 5 mm across (may be caused by coalescent papules). Vesicle: Fluid-filled raised lesion 5 mm or less across. Bulla: Fluid-filled raised lesion greater than 5 mm across. Blister: Common term used for vesicle or bulla. Pustule: Discrete, pus-filled, raised lesion. Wheal: Itchy, transient, elevated lesion with variable blanching and erythema formed as the result of dermal edema. Scale: Dry, horny, platelike excrescence; usually the result of imperfect cornification (i.e., keratinization). Lichenification: Thickened and rough skin characterized by prominent skin markings; usually the result of repeated rubbing in susceptible persons. Excoriation: Traumatic lesion characterized by breakage of the epidermis, causing a raw linear area (i.e., a deep scratch)Onycholysis: Separation of nail plate from nail bed.
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micro-scopic (histologic) TERMS
• hyperkeratosis• parakeratosis• hypergranulosis• acanthosis• papillomatosis• acantholysis• spongiosis• hydropic swelling (ballooning)• exocytosis• erosion• ulceration• vacuolization• lentiginous www.freelivedoctor.com
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MICROSCOPIC TERMSHyperkeratosis: Thickening of the stratum corneum, often associated with a qualitative abnormality of the keratin. Parakeratosis: Modes of keratinization characterized by the retention of the nuclei in the stratum corneum. On mucous membranes, parakeratosis is normal. Hypergranulosis: Hyperplasia of the stratum granulosum, often due to intense rubbing. Acanthosis: Diffuse epidermal hyperplasia. Papillomatosis: Surface elevation caused by hyperplasia and enlargement of contiguous dermal papillae. Dyskeratosis: Abnormal keratinization occurring prematurely within individual cells or groups of cells below the stratum granulosum. Generally the same as DYSPLASIA.Acantholysis: Loss of intercellular connections resulting in loss of cohesion between keratinocytes. Spongiosis: Intercellular edema of the epidermis. Hydropic swelling (ballooning): Intracellular edema of keratinocytes.Exocytosis: Infiltration of the epidermis by inflammatory or circulating blood cells. Erosion: Discontinuity of the skin exhibiting incomplete loss of the epidermis. Ulceration: Discontinuity of the skin exhibiting complete loss of the epidermis and often of portions of the dermis and even subcutaneous fat. Vacuolization: Formation of vacuoles within or adjacent to cells; often refers to basal cell-basement membrane zone area. Lentiginous: Referring to a linear pattern of melanocyte proliferation within the epidermal basal cell layer. Lentiginous melanocytic hyperplasia can occur as a reactive change or as part of a neoplasm of melanocytes.
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SKIN PATHOLOGY
• DEGENERATION
• INFLAMMATION, i.e., DERMATOSES
• NEOPLASMS: Epidermis, Dermis, Benign, Malignant
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SKIN PATHOLOGY• Pigmentation• Epidermal tumors,
benign• Epidermal tumors
premalignant• Epidermal tumors,
malignant• Dermal tumors• “Immigrant” tumors• Maturation
disorders
• Dermatoses, acute• Dermatoses, chronic• Blisters (Bullae)• Appendage (adnexal)
disorders• Panniculitis• Infection/Infestation
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PIGMENTATION DISORDERS
• VITILIGO• FRECKLE (EPHELIS)• MELASMA• LENTIGO• NEVUS• “DYSPLASTIC” NEVUS• MALIGNANT MELANOMA
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NEVI• Many, many adjectives and classifications.• The MAIN things to differentiate from
melanomas• Junctional (more pigmented, more
closely associated with melanoma)• Intradermal• Compound (both)
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Intradermal nevus
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Intradermal nevus
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Junctional nevus
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Junctional nevus.
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MALIGNANT MELANOMA• Incidence rising, VERY much• Related to SUN like ALL skin cancers are• The only primary skin cancer that can kill you
(except for the RARE Merkel cell tumor)• QUICKLY METASTASIZES• Has both VERTICAL and HORIZONTAL growth
phase but prognosis is 100% related to the VERTICAL, (BRESLOW staging, TNM too)
• DIFFICULT to differentiate from NEVUS clinically and often microscopically
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BENIGN Epidermal Tumors
• Seborrheic Keratosis• Acanthosis Nigricans• Fibroepithelial Polyp (skin tag)• Epidermal (inclusion) Cyst• Adnexal tumors : Eccrine, Apocrine• Keratoacanthoma
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Squamous “horn cysts” in seborrheic keratosis
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Acanthosis nigricans, often associated with diabetes mellitus
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Acanthosis nigricans, often associated with diabetes mellitus
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Fibroepithelial polyp, or “skin tag”
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Fibroepithelial polyp, or “skin tag”
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Epidermal inclusion cyst, the overlying skin looks normal.
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Epidermal inclusion cyst
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ADNEXAL TUMORS• HAIR FOLLICLES
• SEBACEOUS GLANDS
• SWEAT GLANDS–ECCRINE–APOCRINE
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Keratoacanthoma, the MAIN lesion to differentiate from squamous cell carcinoma
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Keratoacanthoma, the MAIN lesion to differentiate from squamous cell carcinoma
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Keratoacanthoma, the MAIN lesion to differentiate from squamous cell carcinoma
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PREMALIGNANT/MALIGNANT
• ACTINIC (Solar) KERATOSIS, i.e. precursor to SCC
• SQUAMOUS CELL CARCINOMA, squamous “pearls”, intercellular bridges
• BASAL CELL CARCINOMA, by far, MOST COMMON, BLUE palisading nests
• MERKEL CELL CARCINOMA (TUMOR), VERY MALIGNANT AND LETHAL, LOOK LIKE SMALL CELL CA. OF LUNG
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GENERAL COMMENTS
• BOTH SCC and BCC related to SUN (i.e., radiation) exposure.
• SCC also related to As, carcinogens, chaw, betel nut, HPV, familial, etc.
• BOTH SCC and BCC can do local damage but very rarely metastasize or kill.
• MERKEL CELL tumors metastasize early and extensively, like melanomas.
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Actinic keratosis
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Actinic keratosis vs. squamous cell carcinoma
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Squamous cell carcinoma, infiltrating..... Bowen’s disease
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Squamous cell carcinoma, infiltrating. Note the “pearls”.
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Squamous dysplasia, perhaps actinic keratosis, or something leading into squamous cell carcinoma.
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The commonest malignancy of skin, BCC, i.e., Basal Cell Carcinoma, typical appearance.
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The commonest malignancy of skin, BCC, i.e., Basal Cell Carcinoma, typical appearance. Note the PERIPHERAL PALISADING!!!
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Merkel cell tumor, very highly malignant and usually fatal, looks EXACTLY like a small cell carcinoma of the lung.
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DERMIS TUMORS• DERMATOFIBROMA (BENIGN FIBROUS
HISTIOCYTOMA)
• DERMATOFIBROSARCOMA PROTUBERANS (DFP)
• MALIGNANT FIBROUS HISTIOCYTOMA (MFH)
• XANTHOMA
• VASCULAR TUMORS of various types
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Benign fibrous histiocytoma, or dermatofibroma
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Benign fibrous histiocytoma, or dermatofibroma
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Large fibrous histiocytoma, perhaps a dermatofibrosarcoma protuberans?
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Malignant fibrous histiocytoma
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Xanthomas filled with cholesterol and lipids, to give the “foamy” appearance.
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Xanthoma filled with cholesterol and lipids, to give the “foamy” appearance.
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Hemangioma, often a congenital “birth mark”, which can regress significantly with aging.
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Kaposi’s sarcoma
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Cellular “Immigrants”
• Langerhans cells (Histiocytosis)
• Mycosis Fungoides (T-Cell cutaneous lymphoma)
• Mastocytosis (mast cell tumors)
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Icthyosis, usually genetic.
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DERMATOSES• ACUTE
– URTICARIA (i.e., “HIVES”)
– ECZEMA
– ERYTHEMA MULTIFORME
• CHRONIC
– PSORIASIS– SEBORRHEIC
DERMATITIS– LICHEN PLANUS– LUPUS
ERTHYMATOSUS
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URTICARIA
• DERMAL EDEMA• DILATATION of VASCULAR
SPACES• EARLY PERIVASCULAR CUFFING
OF INFLAMMATORY CELLS
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ECZEMA(aka, acute eczematous dermatitis)
• A myriad of ACUTE inflammatory disorders, with allergic, drug related, sun related etiologies
• The common histologic feature is SPONGIOSIS
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Eczema
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Eczema with spongiosis
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spongiosis
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Pustules, ulcerated
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PSORIASIS• 1-2% of USA
• Elbows, Knees
• Parakeratosis, generalized epidermal hyperplasia, elongation of the rete pegs, extensive chronic inflammatory cell infiltrates, “MUNRO” intraepidermal microabscesses
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Classical psoriasis, parakeratosis, hyperplasia, rete peg elongation, chronic inflammation, microabscesses (of Munro)
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SEBORRHEIC DERMATITIS
IN HIVLICHENPLANUS
LUPUS
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STASIS DERMATITIS
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STASIS DERMATITIS
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STASIS DERMATITIS
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STASIS DERMATITIS
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STASIS DERMATITIS
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BULLOUS DISEASES
• PEMPHIGUS(VULGARIS)• BULLOUS PEMPHIGOID• DERMATITIS HERPETIFORMIS• EPIDERMOLYSIS BULLOSA• PORPHYRIA
• “ACANTHOLYSIS” is the common unifying finding, as is basement membrane immunoglobulins
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Pemphigus, ruptured, scabbed bullae
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Pemphigus, fresh bullae
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AcantPemphigus, fresh bullaeholysis in the bullous family of diseases
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ACNE VULGARIS• Bread and Butter of dermatology practice
• Sebaceous duct blockage with secondary inflammation is main feature
• bacterial lipases of Propionibacterium acnes break down sebaceous oils, and the resulting fatty acids acts as irritants
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PANNICULITIS
.ERYTHEMA NODOSUM, (red nodules on legs)
.ERYTHEMA INDURATUM
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INFECTION/INFESTATION
• VERRUCAE, viral (HPV)
• MULLUSCUM CONTAGIOSUM, viral
• IMPETIGO, bacterial, staph strep
• FUNGI
• ARTHROPODS
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Papillomatous epidermal hyperplasia is the most consistent feature of verrucae (warts)
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Molluscum contagiosum.
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Impetigo
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TINEAS…
• …Capitis (Scalp ringworm)• …Barbae• …Corporis (Ringworm)• …Cruris (Jock itch)• …Pedis (Athlete’s foot)• …Onychomycosis (nail)
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TINEAS
• Trichophyton species• Microsporum species• Epidermophyton species
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Ringworm of scalp
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Tinea barbae
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Ringworm
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Tinea cruris, or jock itch
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Athlete’s foot, or tinea pedis
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Onychomycosis
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PAS stain of hyphae
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PAS stain of hyphae
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ARTHROPODS• Bites
• Stings
• INFESTATIONS
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ARTHROPODS• Pediculosis
• Demodex
• Ticks, Mites
• Scabies
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Scabies in it’s most common location