DISEASE

CERVICAL CANCER

WORLD HEALTH PROBLEM

ELECTRON FOTOGRAPHS OF PAPILLOMAVIRUSRESPONSIBLE FOR CERVICAL CANCER

Pan American Health OrganizationPan American Health OrganizationPan American Health OrganizationPan American Health Organization

INFECTED PEOPLE WITH PAPILLOMAVIRUS:

500.000 cases of invasive cervical cancer

10 millon of High grade lesions

30 millon of Low grade lesions

300 millon cases of infected people with papillomavirus

GRAN SUBREGISTRO: 5 o 6 de cada 10 340 MILLON PERSONS

NATURAL HISTORY OF CERVICAL CANCERNATURAL HISTORY OF CERVICAL CANCERETIOPATOGENIA OF CERVICAL NEOPLASIAETIOPATOGENIA OF CERVICAL NEOPLASIANATURAL HISTORY OF CERVICAL CANCERNATURAL HISTORY OF CERVICAL CANCERETIOPATOGENIA OF CERVICAL NEOPLASIAETIOPATOGENIA OF CERVICAL NEOPLASIA

Social Health Problem

It is very important to consider that, when a women gets infected with papillomavirus and develop cervical cancer, this condition have a very high cost in their families as well for the Health System. Because treatment requires a very high infraestructure and high price drugs. In many cases in develop countries woman is the responsible for the maintenance of the family. This situation makes even more expensive the social cost generated for this disease.

CERVICAL CANCER SOLUTION

Vaccinia Virus MVA

Excellent antigen presentation

Estimulates the Immne system very efficiently

MVA E2

Healing Therapy

JUNE 2015CONFIDENCIAL

CERVICAL CANCER

EXAMPLES OF LESIONS TREATED WITH MVA E2

Rosales, C. Cancer Immunology Immunotherapy. (2000)

MVA E2 eliminatesTumor in rabbits

C 201014 V1-B 201014 V1-A

Fig 2

Patient Number

205136 Week 0 Week 4

Week 8 Week 12

Figure 3

Patient Number

205025

205257

Week 0 Week 14

Figure 2

 

Larynx lesions

Conventional treatments according to the lesion to be treated

TREATMENT COST RESULTS

CRYOSURGERY: ELIMATION OF LESIONS BFREEZING WITH NO3

200-250 USD

ELIMINATES LESIONS BUT RECURRENCES ARE VERY OFTENDOES NOT ELIMATES PAPILLOMAVIRUS

CHIMIOTHERAPY:CHEMICAL DRUGS USED TO INHIBIT TUMOR GROWTH

20,000-30,000 USD

50 % EFFICACYDOES NOT ELIMINATES PAPILLOMAVIRUS

CONIZATION:ELIMINATION OF LESION BY SURGERY PROCEDURES

400-2000USD

ELIMATES LESIONS BUT RECURRENCES APPEARDOES NOT ELIMINATESPAPILLOMAVIRUS

RADIOTHERAPY:USE OF RADIATIONS TO DESTROY TUMOR CELLS

25,000-35,000 USD

50 % EFFICACYDOES NOT ELIMINATES PAPILLOMAVIRUS

MVA E2 500 USA 95 % RFFICACYELIMINATES PAPILLOMAVIRUS

COMPARATIVE COST IN TREATMENTS

1. MVA E2 IS CAPABLE OF ELIMINATE ALL LESIONS GENERATED BY PAPILLOMAVIRUS

2. MVA E2 GENERATES ANTIBODIES AND CITOTOXIC CELLS AGAINST TUMOR CELL BEARING PAPILLOMAVIRUS

3. MVA E2 ELIMINATES PAPILLOMAVIRUS FROM INFECTED-PATIENTS

CONCLUSION FROM CLINICAL TRIALS PHASE I, II AND III

References