Discussion Group 2 - European Food Safety Authority · Discussion Group 2 Case study: Gene drive...
Transcript of Discussion Group 2 - European Food Safety Authority · Discussion Group 2 Case study: Gene drive...
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Discussion Group 2Case study:
Gene drive modified agricultural pests
Network: PULLMAN
@EFSA_EU
Brussels, 15 May 2019
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• Formally devising plausible pathways to harm that describe how a proposed activity could be harmful (i.e., impact a protected value adversely)
• Formulating risk hypotheses (i.e., hypotheses of no harm or of no unacceptable risk) about the likelihood and severity of such events
• Identifying the information that will be useful to test the risk hypotheses
• Developing a plan to acquire new data for hypothesis testing should tests with existing information be insufficient for decision-making
Problem formulation concepts
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• Insect pests cause important losses in agricultural productivity
• Drosophila suzukii (Spotted wing Drosophila) damages fruit industry
• Recently invaded North America and Europe
• Infestations treated with broad-spectrum insecticides• Not always effective and intensive use associated with shortcomings
• Gene drive technology could be applied for population suppression • Targeting genes essential for development or viability
Gene drives to control an agricultural pest
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• Biodiversity and ecosystems
• Toxicity to non-target organisms
• Alteration of food networks
• Impact on ecosystem services
• Niche replacement - pest
• Impact on pest fitness
• Plant health• Niche replacement – plant
pathogens• Increased vectorial capacity
• Increased pathology
Protection goals and potential risks
• Human/animal health• Accidental exposure leading to
toxicity or allergenicity
• Water, soil and air quality, agriculture or natural resources• Impact by gene drive modified pest
• Management practices• Impact on other control strategies• Failure of control strategy altering
pest incidence
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Problem formulation template
Plausible pathway to
harm
Testable risk
hypotheses (compared
with GM insects)
Relevant information
to test risk hypotheses
Means to gather
relevant information
(and feasibility)
Protection goal: …
Step1 … … … …
Step2 … … … …
Step3 … … … …
Step4 … … … …
Step5 … … … …
Step6 … … … …
Step7 … … … …
Step8 … … … …
Step9 … … … …
Harm: …