discovery of the structure of dna
description
Transcript of discovery of the structure of dna
![Page 1: discovery of the structure of dna](https://reader036.fdocuments.net/reader036/viewer/2022081418/56814803550346895db535cf/html5/thumbnails/1.jpg)
DISCOVERY OF THE STRUCTURE OF DNA
Hank Oliver and Chelsea Peacock
![Page 2: discovery of the structure of dna](https://reader036.fdocuments.net/reader036/viewer/2022081418/56814803550346895db535cf/html5/thumbnails/2.jpg)
Frederick Griffith
Discovered the process called transformation
Found a transforming agent that survived heat and change a bacteria to virulent
![Page 3: discovery of the structure of dna](https://reader036.fdocuments.net/reader036/viewer/2022081418/56814803550346895db535cf/html5/thumbnails/3.jpg)
Oswald Avery and Colleagues
Proved DNA was the transforming compound Used protein-destroying enzymes to destroy proteins, RNA-destroying enzymes to destroy RNA, and DNA- destroying enzymes to destroy DNA. Transformation was stopped when DNA-destroying enzymes were used.
![Page 4: discovery of the structure of dna](https://reader036.fdocuments.net/reader036/viewer/2022081418/56814803550346895db535cf/html5/thumbnails/4.jpg)
Alfred Hershey & Martha Chase
Performed experiment with T2 bacteriophage
Using radiolabeled proteins and DNA and followed them.
Experiment proved DNA was transforming agent
![Page 5: discovery of the structure of dna](https://reader036.fdocuments.net/reader036/viewer/2022081418/56814803550346895db535cf/html5/thumbnails/5.jpg)
Rosalind Franklin & Raymond Gosling Worked together to produce the first X-
ray diffraction pictures of DNA Their picture of DNA was stolen by
Watson & Crick to determine the structure of DNA
![Page 6: discovery of the structure of dna](https://reader036.fdocuments.net/reader036/viewer/2022081418/56814803550346895db535cf/html5/thumbnails/6.jpg)
Erwin Chargaff
The amount of cytosine equals the amount of guanine and the amount of adenine equals the amount of thymine.
Adenine ALWAYS pairs with Thymine; Guanine ALWAYS pairs with Cytosine – Chargaff’s Rule
![Page 7: discovery of the structure of dna](https://reader036.fdocuments.net/reader036/viewer/2022081418/56814803550346895db535cf/html5/thumbnails/7.jpg)
Maurice Wilkins
Studied the orientation of purines and pyrimidines in DNA
Developed well-defined X-ray diffraction pictures of DNA which led to Watson and Crick’s DNA model
![Page 8: discovery of the structure of dna](https://reader036.fdocuments.net/reader036/viewer/2022081418/56814803550346895db535cf/html5/thumbnails/8.jpg)
James Watson & Francis Crick First to determine structure of DNA Double helix Chargaff’s Rule Made of sugar-phosphate backbone with
bases hydrogen bonded together holding two strands together
![Page 9: discovery of the structure of dna](https://reader036.fdocuments.net/reader036/viewer/2022081418/56814803550346895db535cf/html5/thumbnails/9.jpg)
References
Griffith Experiment
http://www.nature.com/scitable/topicpage/isolating-hereditary-material-frederick-griffith-oswald-avery-336
Avery Experiment
http://study-biology.wikispaces.com/DNA+and+Genetic+Information
Hershey & Chase Experiment
http://www.accessexcellence.org/RC/VL/GG/hershey.php
Rosalind Franklin’s X-ray Picture
http://biology.kenyon.edu/courses/biol63/dna-prot/xray.html
Rosalind Franklin Picture
http://askabiologist.asu.edu/Rosalind_Franklin-DNA
Raymond Gosling Picture
http://kingscollections.org/exhibitions/archives/dna/key-individuals/gosling
Image for Chargaff’s Rule
http://www.odec.ca/projects/2004/mcgo4s0/public_html/t2/dna.html
Chargaff Picture
http://sanycao-sbi4u.blogspot.com/2012/02/scientists-great-contributions.html
![Page 10: discovery of the structure of dna](https://reader036.fdocuments.net/reader036/viewer/2022081418/56814803550346895db535cf/html5/thumbnails/10.jpg)
References
Maurice Wilkins Picture
http://scarc.library.oregonstate.edu/coll/pauling/dna/pictures/portrait-wilkinsmodel.html
Watson and Crick Picture
http://www.chemheritage.org/discover/online-resources/chemistry-in-history/themes/biomolecules/dna/watson-crick-wilkins-franklin.aspx
DNA Structure
http://library.thinkquest.org/24355/data/details/media/dnastructure.html