Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor...

7
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity Leticia Corrales, Laura Hix Glickman, Sarah M. McWhirter, David B. Kanne, Kelsey E. Sivick, George E. Katibah, Seng-Ryong Woo, Edward Lemmens, Tamara Banda, Justin J. Leong, Ken Metchette, Thomas W. Dubensky, Thomas F. Gajewski Cell Reports Volume 11, Issue 7, Pages 1018-1030 (May 2015) DOI: 10.1016/j.celrep.2015.04.031 Copyright © 2015 The Authors Terms and Conditions

Transcript of Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor...

Page 1: Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity Leticia Corrales, Laura Hix Glickman,

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity 

Leticia Corrales, Laura Hix Glickman, Sarah M. McWhirter, David B. Kanne, Kelsey E. Sivick, George E. Katibah, Seng-Ryong Woo, Edward Lemmens, Tamara Banda, Justin J. Leong, Ken Metchette, Thomas W. Dubensky, Thomas F. Gajewski 

Cell Reports Volume 11, Issue 7, Pages 1018-1030 (May 2015)

DOI: 10.1016/j.celrep.2015.04.031

Copyright © 2015 The Authors Terms and Conditions

Page 2: Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity Leticia Corrales, Laura Hix Glickman,

Figure 1

Cell Reports 2015 11, 1018-1030DOI: (10.1016/j.celrep.2015.04.031) Copyright © 2015 The Authors Terms and Conditions

Page 3: Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity Leticia Corrales, Laura Hix Glickman,

Figure 2

Cell Reports 2015 11, 1018-1030DOI: (10.1016/j.celrep.2015.04.031) Copyright © 2015 The Authors Terms and Conditions

Page 4: Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity Leticia Corrales, Laura Hix Glickman,

Figure 3

Cell Reports 2015 11, 1018-1030DOI: (10.1016/j.celrep.2015.04.031) Copyright © 2015 The Authors Terms and Conditions

Page 5: Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity Leticia Corrales, Laura Hix Glickman,

Figure 4

Cell Reports 2015 11, 1018-1030DOI: (10.1016/j.celrep.2015.04.031) Copyright © 2015 The Authors Terms and Conditions

Page 6: Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity Leticia Corrales, Laura Hix Glickman,

Figure 5

Cell Reports 2015 11, 1018-1030DOI: (10.1016/j.celrep.2015.04.031) Copyright © 2015 The Authors Terms and Conditions

Page 7: Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity Leticia Corrales, Laura Hix Glickman,

Cell Reports 2015 11, 1018-1030DOI: (10.1016/j.celrep.2015.04.031) Copyright © 2015 The Authors Terms and Conditions