Digital Co-60 Radiotherapy System
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Transcript of Digital Co-60 Radiotherapy System
Digital Co-60 Radiotherapy System -----------------------------------------------
Gyro Knife
GammaStar Medical Group Ltd. Address: 15F Multi-media Building, 757 West Guangzhong Rd., Zhabei
District, Shanghai, P. R. China Website: www.gammastar.com E-mail: [email protected]
Tel: +86-21-51095758 Fax: +86-21-61404252
April 16, 2007
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Table of Content COMPANY PROFILE······················································································································2
INTRODUCTION OF GYRO KNIFE ·····························································································4
BRIEF INTRODUCTION ········································································································4
TECHNICAL SPECIFICATIONS····································································································6
CLINIC APPLICATIONS ··············································································································15
LIST OF CONTRACTED HOSPITALS ························································································16
2
COMPANY PROFILE
GammaStar Medical Group Ltd., a high-tech company with its own proprietary
intellectual property rights and profound expertise, is focusing on the R&D, manufacture
and service of large-scale medical equipment. Technology, Service and Health are the
purpose of company’s persistent development and struggle. Company’s long term
objectives are to become a global medical group and build up top brand of global tumor
radiotherapy chain center.
GammaStar has first-class specialists in the fields of nuclear physics, medicine,
machinery, electronics, software, etc. Our core team had created and impelled the Gamma
– Ray stereotactic radiotherapy industry in China with the compressed over ten-year
industrial experience and the management team has affluent experiences, innovative
spirits, complementary advantages and strong capabilities in integrating various resources
in the industry.
“Digital Co-60 Radiotherapy System” (known as Gyro Knife) is one of the most
advanced precise radiotherapy devices, which is invented by GammaStar Medical Group
Ltd.. Gyro Knife integrates the merits of a linear accelerator and the previous generations
of gamma knife into a single unit. Shanghai GammaStar has all proprietary intellectual
property rights about it. We have already applied and hold the relevant patent, holding the
SFDA in China at 14th May, 2006.
According to statistic research, malignant tumor is the third leading cause of death in the
world nowadays. In China, the malignant tumor is the second leading cause of death.
According to the statistic research from Ministry of Health of the People’s Republic of
China, there is almost 2 million people getting cancer every recent year. 1.4 million
people died because of cancer. (Ministry of Health of the People’s Republic of China –
Disease Control Department, Apr., 2004) Base on the statistic research, there are about
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1,000 radiotherapy equipments in China. However, it is estimated that the actual demand
would be 3,000 units within 5 years. It is a huge potential market. The development of
gamma ray radiotherapy technology can not only release the pain for the patients, but
also bring up this industry with significant potential revenue and meanwhile build up
international academic authority for Chinese radiotherapy industry.
Mr. Shipeng Song, the chief scientist of GammaStar Medical Group Ltd., is the party
member of China Zhi Gong Party and the visiting professor of Huazhong University of
the Science & Technology and University of Shanghai for Science and Technology. Mr.
Song began the research of stereotactic radiotherapy technology in 1992 and up to now
he has obtained over 90 patents for his invention. In 1996, he successfully invented the
rotating gamma knife and which is consequently developed as one of a few advanced
Chinese high tech medical equipments in the world. Because of the rotating gamma knife,
he obtained a lot of awards, such as national technology progress first class award,
Shenzhen Technology Progress first class Award and the golden award of the third
National Technology Communication Convention, etc. Furthermore, the rotating gamma
knife was approved by FDA on May, 1997. Nowadays, the gamma knife is becoming an
industry with billions revenue and it is going to have a drastic growth, which is the
opportunity to us. At present, GammaStar’s primary product is “Digital Co-60
Radiotherapy System” (known as Gyro Knife) as a new generation of radiotherapy
equipment. The technology of “Gyro Knife” is used to treat various benign and malignant
tumors in the whole body, as well as for functional disorders such as Intractable Pain,
Trigeminal Neuralgia, Focal Epilepsy, and Parkinson’s disease. Therefore, Mr. Shipeng
Song is hailed as “Father of China’s gamma knife”.
GammaStar is an innovative and rigorous company seeking to provide the best
radiotherapy solution and professional service for patients worldwide. Together we could
make contribution to the development of cancer care industry not only in China but also
throughout the world.
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INTRODUCTION OF GYRO KNIFE
BRIEF INTRODUCTION
“Digital Co-60 Radiotherapy System” (known as Gyro Knife) is one of the precise
radiotherapy devices, which is invented by GammaStar Medical Group Ltd.. Gyro Knife
integrates the merits of a linear accelerator and the previous generations of gamma knife
into a single unit. As a consequence of the merged advantages, Gyro Knife is able to
significantly increase the Radiotherapy Gain Ratio as a functional radiotherapy center
such that making an evolutional change in the field of cancer care.
l Competitive Advantages in Technology
1. The Gyro Knife is able to flexibly irradiate in different angles since the
principle of the Space Gyroscope has been used. As a result of this revolutionary
change, the Gyro Knife can treat wider types of tumors through the body, e.g.
Super-Accurate treatment for brain, large-field radiotherapy for body and IMRT
(Intensity-Modulated Radiotherapy).
2. The Triple Focusing System: Higher Focus-Skin Ratio; Higher treatment
Accuracy; Smaller Penumbra;
The Triple Focusing System makes the Focus-Skin Ratio, which is the physical indicator
(The dosage in target to the dosage on the skin), to achieve an unreachable high level,
550:1 as measured by Ø160mm ball-phantom. This specific figure tells us that the
damage to the skin is fairly limited while the target tissue has been treatment with a
certain level of dosage. The advantages of this are good protections for normal and
sensitive tissues, and much more flexible treatment plans. Moreover, the penumbra
remains extremely small because of the Triple Focusing System; especially the smallest
is only 0.5mm. The distribution of the relative dosage (we called the Gyro Peak) has
achieve the performance of Brag Peak (Photon Therapy System).
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3. Self-Shielding System: Triple Radiation Protection, which significantly limits
the radiation exposure in the environment and reduces the decoration cost for the
therapy room (i.e. the thickness of wall only needs 0.5m for the Gyro Knife; 0.8 –
1.0m for Gamma Knifes; and 1.5m for the Linear Accelerator).
4. The duration and cost of changing the radiation source: for us is approximately
2 hours, and for others is about 1 – 2 weeks. The cost for us is approximately half of
the others.
5. Superior Efficiency: The Gyro Knife has much the automatic control system
than the Gamma Knife and the Linear Accelerator, so that helps the medical person
working more efficiently and effectively. The system can control the different
collimators and the irradiation time, forming 3-D image at any time. The innovative
Marbletherapy technology make the randomly movement of multi-isocenter become
real, which solving the problem of dosage odds.
6. TPS (Treatment Planning System): Simplifies the treatment procedure, easy to
use.
7. Varies Position Setting: traditional Head Frame and Mask, Optional: the
infer-red positioning system. (Simplifies the treatment procedures and reduce the
patients’ painfulness).
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TECHNICAL SPECIFICATIONS
1. Treatment Head
The treatment head of Gyro Knife has a cast-steel shell with tungsten shielding, and it is
designed to hold the Cobalt-60 radiation source with 7’000 Ci totally. The treatments
head is also used as a container for transportation. The treatment head consists of two
parts: the shell and the source switch. Four different sized collimators are distributed
round the source switch.
1.1 Movement Parameters
1.1.1 Angle
♦ Arc Angle between vertical axis and Photon beam: 25°
♦ Treatment Head’s Rotating angle with gantry around body: ±180°
1.1.2 Speed
♦ Treatment Head Self-Rotation Speed: 30r/min
♦ Rotating speed of Gantry: 1r/min
1.2 Photon Beam Characteristic
1.2.1 Radiation Source
Cobalt-60; Activity Rate > 280Ci/g; Half-life: 5.27yrs;
1.2.2 Dose on focal-spot
2.5 Gy/min through our unique Triple-Focusing.
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1.2.3 Field Sizes and Dose Distribution
♦ ф5mm ±1mm
♦ ф15mm ±3mm
♦ ф25mm ±5mm
♦ ф45mm ±5mm
The Penumbra is between 0.5mm – 5mm
The time of automation of collimators change: < 1 sec.
1.2.4 Isocenter Accuracy (Radiation & Mechanical)
Isocenter Accuracy: ± 1 mm
1.2.5 Safety & Protection
When the source switch is off, the Kerma Rate in air 5cm above the equipment surface is
less or equal to 200μGy, and 1m is less or equal to 20μGy, according to the <GB9706.17
– 1999>.
2. Mechanical System
The Mechanical System is made by the main device and the 3-D Treatment Couch, and
the main device is designed according to the principle of Gyro Rotating Mechanism.
2.1 Gyro Structure
The radiation source is installed in a shielded gyro structure, and the first focusing is
achieved by gyration of the gyro structure. The gyro structure and the gantry will rotate
simultaneously, thus the second focusing is achieved through different incidence angle.
The third focusing is achieved by the revolution of the gantry.
As the consequence of Triple-Focusing, the path of the radiation through the normal
tissue will continuously change so the dose to the normal tissues is distributed instantly
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and widely, while the dose on the target tissues will be integrated to achieve the doctor’s
requirement.
The angle and the speed of the gyro structure’s self-rotating and revolution are able to be
selected, and this is suitable to the doctor’s different treatment plans.
2.2 Rotation Disc
The Rotation Disc is shaped as gyro, the treatment head (radiation source) will rotate as
stated above. Therefore, the Digital Co-60 Radiotherapy is known as GYRO KNIFE. 2.3 3-D Treatment Couch
All motorized movement in vertical, lateral and longitudinal directions, Powered by 3
sets of Servomotors. The system adopts high-accurate transmission drive force to achieve
maximum exactitude, so that the target volume can be placed onto the target.
Movement parameters
♦ X –axis: (Width) ±200mm.
♦ Y –axis: (Height) ±150mm.
♦ Z –axis: (Length) 1200mm.
The discrepancy is contained within ±0.5mm. The speed of the vertical movement is
2000mm/min
3. Positioning System
In order to irradiate the tumor tissues, the radiation dose must be accurately delivered to
the target. Gyro Knife uses body positioning frame and vacuum bag to hold the patient
firmly to the couch, and uses CT/MRI technology to identify the dimension axis in
computerized locating system. The components of the the positioning system for the
whole body include treatment couch and vacuum bag, and the components for head
positioning include head frame, four cylinder, four rivets and two N-shaped bars.
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4. Electric Control System
4.1 Content
♦ Control panel
♦ Computerized control system
♦ Electrical control cabinet
♦ Driving equipment
♦ Power supply and cable
4.2 Control Console
The control panel, CCS, ECC, colour monitoring system, and intercom are altogether
interconnected through cables.
4.2.1 Content
♦ Switch button
♦ Indicator light
♦ Computerized control system
♦ Intercom system
♦ Colour monitor
4.2.2 Control function
♦ General power supply switch
♦ System power supply indicator light
♦ Radiation off indicator light
♦ Radiation on indicator light
♦ Malfunction alarm indicator light
♦ Emergency operate button
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4.3 Computerized Control System
From computerized control system, the following information could be controlled and
realized
♦ Information of opening and closing of the shielding door
♦ Gantry position (angle) information
♦ Self-rotating speed of treatment head
♦ Radiation On/Off information
♦ Position information of the treatment couch
♦ Alarm information
4.4 Electrical Control Cabinet
Include programmable controller, driving device, transformer set, air switch contactor,
connection arranging and AC/DC voltage switch device, etc.
External environment condition of the electrical control cabinet
♦ Room temperature: during operation: 0~40℃
♦ Storage/during transportation: -20~60℃
♦ Relative humidity: ≤75%
♦ Tremor: ≤0.5G
4.5 Driving Device
Include 3D treatment couch positioning driving servo, great gantry driving frequency
conversion electromotor, source switch rotating frequency conversion electromotor,
source switch control stepper motor and high-accuracy rotation encoder.
4.6 Power
4.6.1 Input power
♦ Voltage: Three phases 380VAC ± 10%
♦ Frequency: 50HZ ± 1HZ
♦ Rating current: 40A/phase
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4.6.2 UPS
♦ Power: 3KVA
♦ Continues work time: 10Min≧
♦ Capacity: Ensure source switch to be reliably switched off; treatment couch
returns to zero position
♦ Switch time: 0
4.7 Others
4.7.1 Equipment’s protecting earthing impedance
♦ Impedance between terminal and mental parts: no more then 0.1Ω
♦ Impedance between earthing foots’ mental parts: no more than 0.2Ω
4.7.2 Continous creepage under normal working temperature
No more than 5 mA under normal condition; no more than 10 mA under single
malfunctioning condition
5. Treatment System
5.1 Treatment Operation Procedures
♦ Preparation before treatment
♦ Patient positioning
♦ Clinical image diagnostic equipment (such as CT, MRI) scan
♦ Making treatment plan with TPS software
♦ Treatment in operation for the patient
♦ Treatment finished
5.2 Treatment Planning System (TPS)
♦ Contouring 3D image of treatment position of pathological changes and
important organs including body surface profile according to the inputted CT/MRI
image data with positioning mark point.
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♦ Evaluate incidence directions, magnitude, weighted dosage and target position;
constitute the treatment plan of optimizing partition between pathological changes
and normal tissues especially important organs in terms of dosage distribution
♦ Print out the treatment plan details and detailed data of treatment positioning.
6. Security System
6.1 Identification
♦ Starting up the control system requires keys exclusively. Keys should be
kept by the person specially assigned for the task, such as radiotherapist or
physicists.
♦ Logging on TPS requires fingerprint.
♦ TPS adopts multi passwords. The passwords are classified by different
rights.
6.2 Alarm System
♦ Dosimeters in treatment room are connected to the alarm system. It can
immediately give tonetic and photic alarms while the radiation dosage rate over the
planned quantity.
♦ Indication Light indicating radiation status will be installed in the treatment
room.
♦ Indication Light indicating radiation status will be installed outside the
shielding door.
♦ Control system has the signals indicating the shielding status. The radiation
source would be turn off while the shielding door is open and giving alarms.
♦ Different alarm signals in computer indicate different faults in control
systems.
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6.3 Emergencies
♦ USP switch on automatically while black out during treatment process.
Radiation source switch off., 3D treatment couch draw back, treatment process cease,
no hurt to the patients.
♦ During the treatment process, if the operators find problems or the patients are
abnormal, the operators can push the “emergency operation” button to stop the
treatment process. The radiation source is switched immediately. 3D treatment couch
draws back. The treatment process is stopped.
♦ When the radiation source can not be stopped due to mechanical fault, manual
operation can be used. The radiation dosage is under 1/20 of the operators’ annual
radiation dosage when using manual operation.
7. Others
7.1 Long-distance Dosimeters
It is installed in the radiation area in the treatment room with 220VAC.
7.2 CCTV
220V 50Hz, including one color monitor, camera and fixation.
7.3 Intercom
220V 50Hz
7.4 Installation
The installation of Gyro Knife is executed by Shanghai GammasStar Technology
development Co., Ltd. or authorized engineers. The installations include:
♦ Appropriately install the equipment according to treatment room layout
including all cables. Connect the equipment to the control system and the provided
power output.
♦ Put the radiation source into the treatment head.
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♦ Acceptance test protocol
♦ Operation training
7.5 Installation Condition
7.5.1 Electric
Power requirement:
♦ 3 phase 380VAC±10%, 50Hz,7.5kVA
♦ Electricity protection: 30 amp. Air switch
♦ All external connections are connected to electric control system
7.5.2 Environment requirement
♦ Working temperature range: 10°C-40°C
♦ Working humidity range: <90% RH
7.5.3 Treatment room layout requirement
Refer to the treatment room layout
7.6 General information
7.6.1 Weight
♦ Standard equipment: 7,000kg
♦ Floor area of the treatment room: >40 m2
7.6.2 Floor Weight Bearing
Normal value is 1,800kg/ m2
7.6.3 Standard dimension of all equipment including treatment couch
♦ Shape demension: 4,100mm x 2,000mm x 2,100mm
♦ Maximum equipment height (above the floor after decoration) 2,100mm
♦ Gantry maximum rotating diameter: 1,000mm
♦ Maximum distance of stretch-out to draw-back: 4,100mm
15
CLINIC APPLICATIONS
A. Applications for Neuro
1. Cranial tumors: Skull-base tumours/chordoma/chondrosarcoma, Craniopharyngioma, Ependymoma,
Glomus Tumour, Haemangioblastoma, Nasopharynx Carcinoma, Pineal Tumour,
Primary Low Grade Giloma, Schwannoma, Trigeminal Neuroma; Intracranial neoplasm
2. Vascular Disorders:
Aneurysm, Arteriovenous Malformation, Cavernous Angioma
3. Functional Disorders:
Intractable Pain, Trigeminal Neuralgia, Focal Epilepsy, Parkinson's disease
4. Psychoneural:
Schizophrenia, obsessive-compulsive disorder, addiction onset
B. Applications for the body 1. Various benign and malignant tumors in the body:1. Thorax:
Lung cancer, esophagus cancer, mediastinum cancer 2. Abdominal:
Liver cancer, gastric carcinoma, gallbladder cancer, pancreas cancer, gut cancer 3. Systema urogenitale:
Kidney cancer, urinary bladder cancer, prostate cancer, pancreas tumors 4. Gynecologic tumor:
Breast cancer, cervix cancer, ovary cancer, endometrial cancer
16
LIST OF CONTRACTED HOSPITALS
1. Huaibei People’s Hospital (Anhui province)
2. Shanghai Changzheng Hospital (Shanghai)
3. The 98th Hospital of PLA (Army hospital)
4. Xian Changan Hospital (Shanghai)
5. Guangxi Minzu Hospital (Guangxi province)
6. Qian Dong Nan People’s Hospital of Guizhou Province ( Guizhou
Province)
7. The 152nd Hospital of PLA (Army hospital)
8. Kaifeng People’s Hospital (Henan province)
9. Zhuzhou Zhi Cheng Bo Ai Hosptial (Hunan province)
10. The Hospital of Wuhan University of Science and Technology (Hubei
province)
11. The Hospital of Liaoning University of Chinese Medicine (Liaoning
province)
12. Hanzhong 3201st Hospital (Shanxi province)
13. The 306th Hospital of PLA (Army hospital)
14. Xianghuan KangDa Hospital (Hubei hospital)
15. Shiyan People’s Hospital (Hubei hospital)
16. Wu Jing Zong Dui Hospital of Jiang Xi Province (Army hospital)
17. Jinjiang Central Hospital (Fujian province)
17
18. Yangzhou Hospital of TCM (Jiangshou province)
19. Jiangbei Hospital ( Southeast University)
20. The 97th Hospital of PLA (Army hospital)
21. The 4th Hospital of China Medical University ((Army hospital)
22. Xianyang Central Hospital (Shanxi province)
23. Shanghai Cancer Hospital (Shanghai)
24. Jiamusi Cancer Hospital (Helongjian Province)
25. The 256th Hospital of PLA (Army hospital)
26. Shangrao People’s Hospital (Jiangxi hospital)
27. The 3rd People’s Hospital of Huaian (Jiangshou province)
28. Chizhou People’s Hospital (Anhui province)
29. Nanyang Nanshi Hospital (Henan province)
30. The 7th People’s Hospital of Hebei (Hebei province)
31. Liupanshui Kuangwu Hospital (Guizhou province)
32. Weifang Chinese Traditional Medicine Hospital ( Shandong province)
33. Kamayani Hospital (Aqra, India)
34. National Institution of Neurosurgery (Hungary)
There are total 61 contracted hospitals around the world as at 18th April,
2007 …………