Diana™

Hazardous Drug Compounding System

Automated sterile compounding for the accurate, safe, and efficient preparation

of hazardous drugs.

Diana.A Legacy of Caring.

Diana Kostyra Lopez, MD: The original “Diana” and inspiration for the Diana Hazardous Drug Compounding System.

Dr. Diana Kostyra Lopez was a dedicated and caring pediatrician and the wife of ICU Medical CEO Dr. George “Doc” Lopez. Together, they raised two sons in the idyllic ocean-side community of Laguna Beach, CA, and dedicated their lives to helping others.

In 2006, Diana lost a valiant fight with cancer. Through that tragic event, Doc found a way to both honor the memory of his wife and fulfill a promise he made to her as she was going through cancer treatments.

During chemotherapy, Diana heard her nurses complain of a metallic taste in their mouths and discuss potential health hazards from exposure to chemotherapy drugs. She asked Doc to create a solution that would help keep clinicians safe from exposure, and the result is the ICU Medical line of needlefree oncology solutions, including the Diana system.

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“Diana always cared about others more than she cared about herself. When her oncology nurses told her

about the symptoms they were experiencing as a result of exposure to chemotherapy drugs, she tugged at my

sleeve, looked up at me, and said, ‘fix it.’ I always did whatever she told me to do.”

800.824.7890 | www.icumed.com©2012 ICU Medical Inc. | M1-1317 Rev. 02

— George “Doc” Lopez, MD, Board Certified Internist & CEO, ICU Medical Inc.

Diana™ is the new standard in accuracy, safety, and efficiency for sterile hazardous drug compounding.

Accurate, safe, and efficient hazardous drug compounding technology right at your fingertips.

•• USER-CONTROLLED AUTOMATED COMPOUNDING FOR MAXIMUM ACCURACY AND SAFETY Unlike automated technologies that require huge investments and do not fit within existing workflows, the Diana system cost-effectively keeps pharmacists and technicians in control of the compounding process from beginning to end.

•• CLOSED SYSTEM ASSURES SAFETY OF CLINICIANS AND THE STERILITY OF THE MIX The Diana system fits under the hood of your biological safety cabinet and protects clinicians from exposure to hazardous drugs and accidental needlesticks while protecting the patient preparation from exposure to environmental contaminants.

•• REDUCES RISK OF REPETITIVE STRESS INJURIES Free up pharmacists and technicians from many of the repetitive motions required during preparation and reconstitution and reduce the stresses and injuries that can occur as a result.

•• INCREASES EFFICIENCIES AND REDUCES DRUG WASTE By helping you improve the efficiency of high-volume compounding, the Diana system can deliver workflow efficiencies while helping you reduce drug waste by extracting every drop of drug from every container.

Diana™ is the new standard in accuracy, safety, and efficiency for sterile hazardous drug compounding.

AccurateRepeatable accuracy from a user-controlled automated

system that is so reliable, it only requires calibration once a year.

SafeKeeping clinicians and patients safe from exposure to

hazardous drugs and accidental needlesticks, the Diana system also helps you maintain drug sterility.

EfficientPerfect for low- and high-volume preparations, the Diana

system also minimizes repetitive motion stresses, making filling elastomeric pumps quick and painless.

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CHAN. 1 ACTIVE Diphenhydramine 50 mg/mLDolasetron 20 mg/mLDoxorubicin 2 mg/mLEpirubicin 2 mg/mLEtoposide 20 mg/mL

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User-controlled automation that keeps you in control of the compounding process from beginning to end.

The Diana system’s traceability features provide you with medication name, volume, time, and date information for each preparation you mix. This helps you improve patient safety while supporting preparation quality assurance and pharmacy validation best practices.

Channel 1: 20 mL•• Low-volume transfer

•• Add medication to patient IV bag

•• Add medication to a syringe

•• Add medication to elastomeric pumps

•• Reduce costly drug waste

Channel 2: 50 mL•• High-volume transfer

•• Reconstitute lyophilized drugs

•• Add diluent to patient IV bags

•• Fill a syringe or elastomeric pump

•• Batch-prepare a series of containers

Customizable Drug List for Improved Preparation Traceability The Diana system lets you choose from a pre-loaded list of 100 drugs that can be customized to meet your specific needs, giving you enhanced traceability, improved documentation, and complete validation of each preparation.

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Providing a Complete Record of Each PreparationAfter each mix is completed, the Diana system sends the medication name, volume, time, and date to a printer that creates a label containing preparation information to complement your validation and quality assurance process and help prevent medication errors. •

Diana SN: D21100NCR113

CHAN 1:

DOXORUBICIN 2 mg/mL25.5 mL10-19-12 10:22:28AM

Prepared by:

Additional System Components

Genie® CSTD Vial Access Device Allows access to vials having 20 mm and 28 mm closures

CH-74™ Protected Filter Vial Access DeviceNeedlefree vial access device prevents filter blockage and drug loss during preparation

Spiros® CSTD Male LuerFor use on a syringe or an administration set, spinning and non-spinning configurations available, priming volume is 0.1 mL

Clave® CSTD Bag SpikeFor use on any solution container

Designed to fit the way you work today, the Diana system is safe, easy, intuitive, and accurate.

With an easy-to-follow stepped workflow that keeps pharmacists and technicians in control of the compounding process and a rugged, durable exterior, the Diana system fits both how you work and where you work.

Step One:Choose the proper drug name

from the customizable list of pre-loaded drugs.

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Step Two:Simply enter in the desired

volume on the system’s touch-screen keypad.

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Step Three:Verify that the drug,

volume, channel, and container are correct.

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Step Four:Press the start button and

Diana does the rest, giving you validation when complete.

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Diana System Preparation Sets and Components The Diana system’s proprietary enabling technology includes pre-packaged preparation sets and ICU Medical’s clinically proven simple, safe, and secure ChemoClave needlefree closed systems and closed system transfer devices to help enhance healthcare worker safety and comply with OSHA, NIOSH, ASHP, ISOPP, ONS, APHON, and USP <797>.

•Channel One Cassette with 20 mL syringe(CH4000)

Channel Two Diluent Set with 50 mL syringe, drip chamber, and two Spiros(CH4001)

Channel Two Diluent Set with 50 mL syringe, drip chamber, bag spike, and one Spiros(CH4002)

Diana takes the variation out of manual drug preparation practice and lets you create a repeatable sterile preparation and safe-handling process.

A Completely Closed System Takes Contamination Out of the Equation

Helping Keep You Safe While Preserving the Sterility of Drugs Throughout the Compounding ProcessThe microbiologically and mechanically closed design of the Diana system is accomplished through a series of innovative needlefree components that attach to all containers that are dispensing or receiving a drug in the compounding process to protect the patient preparation from exposure to environmental contaminants while protecting the clinician from both exposure to the drug and accidental needlesticks. •

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