DIAGNOSTIC IMAGING PROGRAM

NATIONAL CANCER INSTITUTE

National Institutes of Health

National Cancer Institute

Diagnostic Imaging Program

Diagnostic Imaging Program: Update

• Money• Organizational comments• Current Programs• Future Plans• Concluding comments

NIH Funding for Imaging

$0

$50

$100

$150

$200

$250

$300

$350

FY 96 FY 97 FY 98 FY 99

DIP

NIH-RAD

NIHImaging

$Millions

DIP Grant Funding

$0

$10

$20

$30

$40

$50

$60

$70

$80

FY 96 FY 97 FY 98 FY 99

$M

Diagnostic Imaging Program(DIP)

DiagnosticImagingBranch

FunctionalImagingBranch

Image-guidedTherapyBranch

Office ofImaging

Technology

Division of Cancer Treatment and Diagnosis(DCTD)

CancerDiagnosisProgram

(CDP)

Develop-mental

TherapeuticsProgram

(DTP)

CancerTherapy

EvaluationProgram(CTEP)

RadiationResearchProgram

(RRP)

NCI

Organization

• 10 FTE’s– D Sullivan, L Clarke, J Hoffman, A

Menkens, B Croft, M Torres, J Smith, L Cooley, S Bowles, L Banh

• 3 Part-time– E Staab, J Tatum, C Langlotz

• Further expansion is space limited

Positions available(of importance to imaging)

• NCRR Director of Bioengineering

• NHLBI Program Director

• NCI Scientific Review Administrator

Radiology 1999; 212:609-614

Recent Programs

Programs Awards AmountRFA: CA-97-020:Cooperative Trials inDiagnostic Imaging (ACRIN)

2 U01 $ 3.0 M yr. 1$ 22 M Tot

RFA: CA-98-024:Development AndApplication of Imaging InTherapeutic Studies

9 R01’s $ 2.8 M yr. 1$ 11.6 M Tot

CA-98-023: Small AnimalImaging Resource Programs(SAIRPs)

5 U01’s $ 5.3 M yr. 1$ 15.3 M Tot

Current Programs(1)

Program Awards AmountRFA: CA –99- 002 – PlanningGrants – Molecular andCellular Imaging Centers (Pre-ICMICs):

6-8 P20’s $ 2.4 yr. 1$ 7.2 M Tot

RFA: CA –99- 004: Molecularand Cellular Imaging Centers:(ICMICs)

2 P50’s peryear

$4.0 M yr. 1$48.0 M Tot

RFA CA-99-015: DiagnosticImaging and Guided Therapyin Prostate Cancer (PhasedInnovation Award)

6-8 R21/R33 $1.6 M yr.1$13.6Tot

PAR-99-149: DiagnosticImaging and Guided Therapyin Prostate Cancer:SBIR/STTR Initiative

R43/R44 Payline

Current Programs(2)Program Awards AmountPA: 99-082/ 083: Development and Testing ofDigital Mammography Displays and Workstations

R0I/ SBIR/STTR). Payline

PA: 98-008: Exploratory/Developmental Grants forDiagnostic Cancer Imaging

R21’s $5.7 M yr. 1

PAR-99-101: Innovative Technologies for theMolecular Analysis of Cancer: Phase InnovationAward

R21/R33 SBIR/STTR(PAR-99-100)

Payline

PAR-99-102: Applications Of InnovativeTechnologies For The Molecular Analysis OfCancer: Phased Technology Application Award

R21/R33 SBIR/STTR(PAR-99-103)

Payline

PAR-99-010: Bioengineering ResearchPartnership Programs (BRP)

R01’s Payline

PAR-99-009: Bioengineering Research Grants(BRG)

R01’s Payline

BAA No. N01-CM-97065-32 Novel Technologies forNoninvasive Detection, Diagnosis and Treatmentof Cancer

Contracts $ 4 M yr.1$16 M Tot

Collaborative Programs

Program Awards Amount

PA 98-092: Shared Resources forScientists Outside NCI Cancer Centers

R01 or P01 Payline

NLM 99-103: Visible Human ProjectImage Processing Tools (NLM)

Contracts

RFA: AI-99-004: New ImagingTechnologies For Autoimmune Diseases

R01’s $3.5 M yr. 1$17.5 M Tot

RFA: CA-99-013: Cancer Intervention andSurveillance Modeling Network (CISNET)

U01’s $1.5 M yr. 1$6.0 M Tot

CTEP Collaborative Programs

Program Awards

CTEP Protocol Review ContractsU01’s

CA-98-007: Pediatric Brain Tumor ClinicalTrials Consortium

U01, imagingrequired

RFA for new Centers U54’s imagingrequired

RFP for Phase I & II clinical trials Contracts imagingrequired

DIP Standards Activities

• DICOM / Working Group on Clinical Trials Data

• RSNA - IHE / RSNA - image archive collaborations

• Structured reporting collaborations: DICOM, SNOMED, ACR, RSNA

• Image database standards: RFA

NCI - Imaging Industry Relations Forum

• Clear description of HCFA decision rules

• Policy for conditional coverage of emerging imaging technologies

• Re-evaluation of FDA policies, esp. re: tracers or procedures of low risk

• Assure full range of NCI support mechanisms for imaging science.

NCI Training Activities

R 25Cancer Education and Career Development

Program

R 25 Cancer Education and Career Development Program

• Multidisciplinary

• Institutional award

• Salary support for PI and core faculty

• Trainee salary up to $75,000

• Research support up to $20,000 per trainee

• 5 yr. grant, renewable

• 8% indirect

K07 / K08 / K23

• K 07 Epidemiology

(limited use by radiology)• K 08 Clinician: Bench science

(limited use by radiology)• K23 Clinician: Patient-oriented (hands-

on; obtain consent form)

(no imaging applications yet)• Salary $75,000/ Research $30,000

T32 Training Grants - Imaging

From 1/97-10/99 (6 NCI deadlines)

• 6.5% of applications submitted were imaging-related

• 57.1% of imaging-related T32s were funded

• 54.2% of T32 applications submitted to NCI were funded

T32 Training Grants - Imaging

Yrs PI Title 24 Kuhl, David Cancer Research Training in Nuclear Medicine 17 Wagner, Henry Res. Training in Use of Tracer Principles in Oncology 14 Brady, Thomas Nuclear Magnetic Research 10 Zerhouni, Elias Research Training in Oncology Imaging 7 Glazer, Gary Advanced Techniques for Cancer Imaging 5 Clouse, Melvin Deaconess Research Training in Cancer Radiology 4 Baum, Stanley Training in Innovative Cancer Imaging Technologies 3 Hawkins, Randall Research Training in Diagnostic Oncology 2 Wehrli, Felix Training in Quantitative Magnetic Resonance Imaging

23 Hoffman, Edward Research Training in Biomedical Physics 23 Bedford, Joel Radiological Sciences Basic to Cancer Research 21 DeLuca, Paul U.W. Radiological Sciences Training Program 18 Alpert, Nathaniel Postgraduate Program in Radiological Science 10 Doi, Kunio Research Training in Medical Physics

Research Training Grant Information

• Call Brian Kimes

301 496 8537

• email:

bk34t@nih.gov

Future Plans - Devices

• Proposed PA: R21/R33 for imaging technology development

• RFP for ultrasound research interface• RFA for spiral CT image database• Proposed program to support production

of beta units for clinical trials• Proposed additional Centers with

technology development component

Future Plans - Pharmaceuticals (Imaging agents)

Pharmaceutical categories of interest:– 1. Non-PET tracers– 2. PET tracers– 3. Bulk agents (pharmacologic effect)– 4. Radiolabeled therapeutic agents

(non-sealed-source agents)

Future Plans - Pharmaceuticals (Imaging agents)

• Proposed program to support development of novel imaging probes.

• Proposed program to support R & D necessary for IND, and provide supply needed for clinical trials.

Concluding Comments

• Molecular imaging is future priority

• DIP funding increased 40 %

• More applications lead to more funding

• Patient accrual needs attention

• Rewards for team science need attention

• Think R25 for research training grants

Sources of NCI imaging information to public

• Website: URL = www.nci.nih.gov/dip/

• Email Newsletter

Handouts available

• URLs of interest

• Training program information

• Copy of Acad Rad article: Radiologic Sciences Research in the Next Century

• DIP Newsletter

• Everything you ever wanted to know …

• Cancer information pamphlets