Diabetes Mellitus Revised, May 2007 Disorder of metabolism Regulated by insulin.
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Transcript of Diabetes Mellitus Revised, May 2007 Disorder of metabolism Regulated by insulin.
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Diabetes MellitusRevised, May 2007
Disorder of metabolism
Regulated by insulin
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FYI:When you eat, your pancreas releases
Insulin into your bloodstream. You allknow by now that every cell in your bodyruns on sugar for energy. Insulin is whatcarries the sugar to and into the cells and makes it usable.
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Classifications…
Type 1 (previously known as IDDM or Insulin Dependent Diabetes Mellitus)
Type 2 ( previously known as NIDDM or non-insulin-dependent Diabetes Mellitus)
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Role of InsulinRegulates the rate of glucose metabolism
Moves glucose into cells
Reduces blood sugar by ^ utilization of carbohydrates
Synthesis of fatty acids and proteins…Ah Oh!
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Symptoms of DM
Hyperglycemia key feature
Classic symptoms are:
Polydipsia
Polyuria
Polyphagia
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Criteria for Medical Diagnosis
Symptoms of Diabetes
Fasting serum glucose level of 126mg/dl or greater
Two-hour postprandial glucose above 200mg/dl during OGTT (Pg1009)
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Microvascular Complications
Basement membrane of capillaries thickens
Exchange of nutrients, gases and waste is impaired
Related to persistent hyperglycemia and aggravated by hypertension & smoking
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Diabetic Retinopathy
Pathological changes in the retina due to DM
Nonproliferative and proliferative
Macula edema ( floaters or spots )
Eye exams should be yearly
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NephropathyKidney disease
Caused by high concentrations of glucose in urine, along w/ HTN, destroy capillaries supplying the renal glomeruli.
S/S persistent proteinuria, ^BP & serum creatinine, hematuria, oliguria and anuria
How to reduce the risk of damage……
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Macrovascular ComplicationsCauses the development of atherosclerosis
Coronary, cerebral, carotid and peripheral blood vessels are affected
Leading to CAD, CVA and PVD
Trmt is directed at weight loss,exercise and quitting smoking
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Neuropathic Complications
Neuropathypathological changes in nerve tissue
Related to poor glucose control and ischemic lesions of nerves
Affects 13% of people w/ diabetes50% chance of having neuropathies if diabetic
for over 25 yrsVariety of symptoms (see pg. 903)
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Foot complications
Related to neuropathy or inadequate blood supply
Ulcers, burns or abscess may easily develop and go unnoticed
Best treatment is prevention
Foot Care See table 44-2, pg 904
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Acute Emergency Complications
1) Acute Hypoglycemia
2) Diabetic Ketoacidosis ( DKA)
3) Hyperglycemic Hyperosmolar Nonketotic Syndrome (HHNKS)
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Acute HypoglycemiaS/S shakiness, nervouseness, irritability, tachycardia,
anxiety, lightheadedness, hunger, tingling or numbness of lips or tongue, diaphoresis, confusion, dizziness
Caused by: too much insulin, not eating enough food, not eating at right time, or inconsistent pattern of exercise
Glucose betw. 50-70 are moderately low
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Hypoglycemia treatment
Conscious patient 10-15gms of quick acting carbohydrates
EX: 4-6 oz of orange or apple juice, skim milk, 3-4 tbsp. Table sugar or corn syrup, 2-3 glucose tablets. Repeat every 15-30 min until glucose is above 60.
Injectable glucagon should be avail if insulin dependent
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Diabetic Ketoacidosis (DKA)Caused by insulin deficiency resulting in the
inability of carbohydrates, proteins and fats to be metabolized.
Pt exhibits hyperglycemia of 300mg/dl, ketonuria and acidosis
Treatment aimed at correcting the 3 main problems: dehydration, electrolyte imbalance and acidosis
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S/S of DKA
Early SxAnorexia, headache, and fatigue, f/b polydipsia, polyuria and polyphagia.
If untreated, dehydration, weakness, lethargy, abd. Pain, N,V, tachycardia, blurred vision, fruity breath.
Late Sx Kussmaul’s respirations, coma & shock
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Hyperglycemic Hyperosmolar Nonketotic Syndrome ( HHNKS)Extremely high glucose levels (>600mg/dl)
Basic defect is lack of effective insulin or inability to use available insulin
Dehydration and hypernatremia develop
May be caused by IV solutions w/ high concentrations of glucose (TPN or dialysis)
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The point is to try and maintain control.
Prolonged time with these types of complications leads to PVD, CVA,and CAD.
And of course the host of problems causedby each
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Medical Treatment for Diabetes Mellitus
1) Nutritional Management
2) Exercise
3) Insulin Therapy
4) Oral Hypoglycemic Drugs
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Nutritional Management
Weight control important component
Emphasis is on a well-balanced diet
Carbohydrate counting is useful with use of insulin therapy or pumps
Considerable education and support to learn guidelines
Always consider personal & ethnic choices
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Exercise
Combine aerobic & anaerobic exercise
Type 1 hyperglycemia may occur w/ exercise if insulin is inadequate
Type 2 exercise makes receptor sites more sensitive to insulin & lowers glucose levels
Avoid excessive exercise if glucose are elevated
Insulin is absorbed quickly when injected into abdomen
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Insulin Therapy
Time Course of Action (Table 46-2)
Route
Concentrations
( U-100 ) has a concentration of 100 units/ml & is most commonly used
Premixed easier to prepare and less risk of error when mixing 2 insulins in 1 syringe
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Dosing Schedules
Conventional Therapy uses a combination of insulins. Admin in AM and PM. Doses are fixed.Monitor BS before meals, twice a day.
Intensive Therapy designed for tight control. 3-4 injections/day. Glucose monitoring is essential 3-5x/day
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Subcutaneous Insulin InfusionContinuous subcutaneous insulin infusion
Delivers regular insulin continuously and a bolus of insulin at mealtimes
Contains 2-3 day supply of insulin
Advantages no need to use intermediate or long acting insulin and more flexibility regarding travel and exercise
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Insulin Mixing
Remember “clear to cloudy”
When mixing short-acting “clear” and longer-acting (cloudy) insulin, draw the “clear” (short-acting) insulin into the syringe first
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Insulin Injection See Figure 1014
Site rotation helps prevent lipohypertrophy or lipoatrophy
Abdomen absorption is 50% faster
ADA recommends rotating sites within one anatomic area
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Oral Hypoglycemic Agents
See 1016
Not insulin substitutes
Some patients may need one dose of insulin at night and then are able to control serum glucose during the day with oral agents
Euglycemia
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Self blood glucose monitoring (SBGM)
• Reduces complications of long term diabetes
• Helps normalize blood glucose levels
• Glycosylated Glucose Levels drawn every 2-3 mos. Helps MD and patients determine how well blood glucose levels are regulated
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Health history and PE
Review nursing diagnosis related outcome criteria and teaching plan pgs 1020
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Hypoglycemia
• Syndrome that develops when blood glucose levels drop below 45-50mg/dl
• Symptoms can occur at different blood levels based on individual tolerances
• Divided into 3 categories:
1)Exogenous 2) Endogenous 3) Functional
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Exogenous hypoglycemia
Caused by outside factors that act on body to produce low blood glucose
1) Insulin
2) Oral hypoglycemic agents
3) Alcohol
4) exercise
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Endogenous hypoglycemia
Caused by excessive secretion of insulin or an increase in glucose metabolism
Usually the result of a tumor or genetics
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Functional hypoglycemia
• Has a variety of causes
1) gastric surgery (post gastrectomy)
2) fasting
3) malnutrition
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Signs and Symptoms
• weakness
• hunger, diaphoresis,
• tremors, anxiety
• irritability,headache
• pallor
• tachycardia
• Confusion, dizziness
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Medical Diagnosis
• Whipple’s Triad
1) Presence of symptoms
2) Documentation of blood glucose when symptoms occur
3) Improvement of symptoms when blood glucose rises
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Medical treatment
• Depends on cause of problem
• Prevention based upon proper food intake is an important treatment component
• Hypoglycemia associated with treatment of diabetes uses different guidelines for treatment
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Nursing care, diagnosis and related Interventions
• Review pg 921-922