Diabetes Melitus Ws
1
DIABETES MELLITUS History of DM Diabetes : Greek : for “passing water like a siphon” Mellitus : Latin for “sweetened with honey” “Ebers Papyrus” (Egyptian, 1500 B.C.) first depiction of diabetes mellitus - urination of excess amounts - manipulation of diet therapy Discovery of Insulin “insulin”= Latin for “island” • 1889; 1st removal of pancreas from a dog to determine the effect of an absent pancreas by Oskar Minkowski • 1921; Discovery of insulin successful treatment of de- pancreatized dog with insulin • 1922; 1st tested in a 14-year-old boy of diabetes in Toronto • 1923; Nobel Prize in Physiology & Medicine Frederick Banting (1891- 1941) Charles Best (1899-1978) Measurement of insulin by RIA Rosalyn S. Yalow (1921- ) • 1950s; first discovery of insulin antibody • 1960s; insulin immunoasay • 1977; Nobel prize for insulin RIA Etiologic classification of diabetes (ADA, 1997 ) • Type 1 diabetes - A: autoimmune mediated b-cell destruction ICAs, islet cell autoantibodies (Ab to insulin, GAD, ICA- 512/IA-2, islet ganglioside…) - B: idiopathic loss of b-cells no evidence of immunologic destruction of b-cells • Type 2 diabetes • Other specific types of diabetes • Gestational diabetes mellitus Type 1 Diabetes mellitus Overt diabetes Abrupt severe hyperglycemi absolut insulin dependent Type 2 Diabetes mellitus PENATALAKSANAAN DM TYPE 2 1
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Transcript of Diabetes Melitus Ws
DIABETES MELLITUS
History of DMDiabetes : Greek : for “passing water like a siphon”Mellitus : Latin for “sweetened with honey”“Ebers Papyrus” (Egyptian, 1500 B.C.)first depiction of diabetes mellitus - urination of excess amounts- manipulation of diet therapy
Discovery of Insulin“insulin”= Latin for “island”• 1889;1st removal of pancreas from a dog to determine the effect of an absent pancreas by Oskar Minkowski• 1921;Discovery of insulin successful treatment of de-pancreatized dog with insulin• 1922;1st tested in a 14-year-old boy of diabetes in Toronto• 1923;Nobel Prize in Physiology & Medicine
Frederick Banting (1891-1941)Charles Best (1899-1978)Measurement of insulin by RIA Rosalyn S. Yalow (1921- )• 1950s; first discovery of insulin antibody • 1960s; insulin immunoasay
• 1977; Nobel prize for insulin RIA
Etiologic classification of diabetes (ADA, 1997)• Type 1 diabetes - A: autoimmune mediated b-cell destruction ICAs, islet cell autoantibodies (Ab to insulin, GAD, ICA-512/IA-2, islet ganglioside…) - B: idiopathic loss of b-cells no evidence of immunologic destruction of b-cells • Type 2 diabetes• Other specific types of
diabetes • Gestational diabetes mellitus
Type 1 Diabetes mellitusOvert diabetes Abrupt severe hyperglycemi absolut insulin dependent
Type 2 Diabetes mellitus
PENATALAKSANAAN DM TYPE 2
1
