DHFR

MICROSPORIDIA

FUNGI (Chytrids)

FUNGI(Ascomycetes)

FUNGI(Basidiomycetes)

FUNGI (Glomeromycetes)

METAZOA

BACTERIA

STREPTOPHYTAGREEN ALGAE

lack 5’-end

0.2

Polaromonas spAcidovorax citrulli

Leptothrix cholodnii

Candidatus Accumulibacter

Bacillus sp

Pasteurella multocida

Fluviicola taffensisEscherichia coli

Micromonas spOstreococcus tauri

Pisum sativum

Arabidopsis thaliana

Ricinus communisPopulus trichocarpa

Nematostella vectensisBranchiostoma floridae

Gallus gallus

Bos taurus

Homo sapiensMus musculus

Glomus intraradicesPneumocystis carinii

Pyrenophora triticiPhaeosphaeria nodorum

Sclerotinia sclerotiorum

Podospora anserina

Glomerella graminicolaGrosmannia clavigera

Gibberella zeae

Nectria haematococcaTrichoderma reesei

Sporisorium reilianumUstilago maydis

Melampsora lariciSchizophyllum commune

Serpula lacrymansLaccaria bicolor

Coprinopsis cinerea

Batrachochytrium dendrobatidisEncephalitozoon cuniculi

Encephalitozoon intestinalisEncephalitozoon romaleae

Encephalitozoon hellem

1/82

0.92/-1/98

1/99

1/73 1/100

0.94/89

1/91

1/100

0.99/-

0.97/73

0.97/-

0.86/-

1/100

1/86

0.99/-0.83/-

0.99/-

0.99/81

1/99

0.82/-1/93

0.93/-

1/100

0.99/770.99/-

1/100

0.87/-

GK

Ilyobacter polytropus

Desulfurispirillum indicum

Desulfurobacterium thermolithotrophum

Thermovibrio ammonificans

Rubrobacter xylanophilus

Arthrospira platensiscyanobacteriumNostoc punctiforme

Lyngbya majusculaCyanothece sp

Natranaerobius thermophilus

Lactobacillus delbrueckiiStreptococcus thermophilus

Haloplasma contractileRuminococcus sp

Serpula lacrymansCoprinopsis cinerea

Laccaria bicolor

Cryptococcus neoformansPuccinia graminis

Malassezia globosaUstilago maydisSporisorium reilianum

Coccidioides posadasii

Meyerozyma guilliermondii

Yarrowia lipolytica

Zygosaccharomyces rouxii

Lachancea thermotoleransCandida glabrata

Saccharomyces cerevisiae

Nematostella vectensisBranchiostoma floridae

Gallus gallusXenopus laevis

Ciona intestinalisDaphnia pulex

Loa loa 312085627

Brugia malayi 170575589

Encephalitozoon cuniculi

Encephalitozoon intestinalis

Encephalitozoon hellem

Encephalitozoon romaleae

MICROSPORIDIA

FUNGI(Ascomycetes)

FUNGI(Basidiomycetes)

METAZOA

BACTERIA

0.2

1/76

0.86/-

0.9/-

1/90

0.99/-

0.94/-

0.84/-0.96/79

0.99/82

1/930.96/79

1/841/95

0.95/72

0.98/-

1/800.81/-

0.9/-

1/100

1/100

1/91

Nosema ceranaeEnterocytozoon bieneusi

NDK

Enterocytozoon bieneusi

Aspergillus terreus

Talaromyces stipitatus

Magnaporthe oryzaeCoccidioides immitis

Nosema ceranae

Penicillium chrysogenumBatrachochytrium dendrobatidis

Neosartorya fischeri

Cryptococcus neoformans

Trichophyton equinum

Ajellomyces dermatitidis

Gibberella zeae

Arabidopsis lyrataBrassica rapa

Paxillus involutus

Malassezia globosa

Coprinopsis cinerea

Danio rerio

Camponotus floridanus

Picea sitchensis

Archaeoglobus profundus

Phaeodactylum tricornutum

Schizophyllum commune

Thalassiosira pseudonana

Macrococcus caseolyticus

Anopheles gambiae

Synechocystis sp

Arthrospira platensis

Rattus norvegicus

Laccaria bicolor

Apis mellifera

Synechococcus sp

Xenopus tropicalisDaphnia pulex

Drosophila mojavensis

Tetraodon nigroviridisCaligus clemensi

Perkinsus marinus

Sorghum bicolor

Physcomitrella patens

Monosiga brevicollis

Ectocarpus siliculosus

Capsaspora owczarzaki

Chelonus inanitus

Phytophthora infestans

Brevibacillus brevis

Geobacillus thermoglucosidasius

Thermosynechococcus elongatus

Oryza sativa

Lepeophtheirus salmonis

Gallus gallus

Trichoplax adhaerens

Selaginella moellendorffii

Ricinus communis

Encephalitozoon intestinalisEncephalitozoon cuniculi

Encephalitozoon romaleaeEncephalitozoon hellem

MICROSPORIDIA

METAZOA

FUNGI(Ascomycetes)

FUNGI(Basidiomycetes)

BACTERIA

STREPTOPHYTA

STRAMENOPILESALVEOLATES

FUNGI (Chytrids)

STRAMENOPILES

0.2

0.98/76

1/71

1/810.99/-

0.87/-0.95/-

1/92

0.91/-0.88/-

1/811/100

1/100

0.91/-0.98/- 1/87

0.9/-1/87

0.92/-0.93/75

1/840.92/-

0.99/-

0.8/-

1/821/96

0.91/760.98/75

0.99/-

0.92/-0.97/-

1/-

0.95/-

1/94

0.93/-1/74

Desulfitobacterium hafniense

Paenibacillus curdlanolyticus

Finegoldia magna

Waddlia chondrophila

Streptobacillus moniliformis

Fusobacterium sp

Providencia rustigianii

Cronobacter sakazakii

Micromonas sp

Chlamydomonas reinhardtii

Arabidopsis thaliana

Ricinus communis

Glycine max

Populus trichocarpa

Puccinia graminis

Cryptococcus neoformans

Schizophyllum commune

Serpula lacrymans

Coprinopsis cinerea

Laccaria bicolor

Yarrowia lipolytica

Penicillium marneffei

Neurospora crassa

Glomerella graminicola

Metarhizium anisopliae

Nectria haematococca

Gibberella zeae

Monosiga brevicollis

Salpingoeca sp

Amphimedon queenslandica

Nematostella vectensis

Apis mellifera

Drosophila persimilis

Bombyx mori

Tribolium castaneum\

Daphnia pulex

Caenorhabditis briggsae

Ascaris suum

Brugia malayi

Salmo salar

Homo sapiens

Mus musculus

Xenopus laevis

PK

MICROSPORIDIA

FUNGI(Ascomycetes)

FUNGI(Basidiomycetes)

METAZOA

BACTERIA

CHOANOFLAGELLATA

STREPTOPHYTAGREEN ALGAE

0.2

1/97

1/1001/78

1/100

1/94

1/100

1/100

1/99

1/-

1/96

1/95

1/84

1/100

1/100

1/-

0.99/-

0.98/-

0.94/-

0.85/-

1/96

0.83/-

1/86

1/1001/81

1/721/98

1/771/98

1/831/95

1/96

1/1001/97

1/841/93 Encephalitozoon romaleae

Encephalitozoon hellem

Encephalitozoon cuniculi

Encephalitozoon intestinalis

Nosema bombycis

TS

Anopheles darlingi

Bradyrhizobiaceae bacterium

Oryza sativa

Kluyveromyces lactis

Agaricus bisporus

Aureococcus anophagefferens

Bacillus smithii

Daphnia pulex

Chlorella variabilis

Oikopleura dioica

Ustilago maydis

Mus musculus

Xenopus laevis

Salpingoeca sp

Litopenaeus vannamei

Pan troglodytes

Branchiostoma floridae

Vitis vinifera

Debaryomyces hansenii

Bradyrhizobium japonicum

Lutiella nitroferrum

Phaeodactylum tricornutum

Exiguobacterium sp

Coprinopsis cinerea

Anaerophaga sp

Selaginella moellendorffii

Ashbya gossypii

Mixia osmundae

Saccharomyces cerevisiae

Serpula lacrymansPiriformospora indica

Phytophthora sojae

Cryptococcus neoformans

Zea mays

Tuber melanosporum

Monodelphis domestica

Trichoplax adhaerens

Ectocarpus siliculosus

Sorghum bicolor

Drosophila melanogaster

Batrachochytrium dendrobatidis

Hydra magnipapillata

Chromobacterium violaceum

Laccaria bicolor

Schizophyllum commune

Scheffersomyces stipitis

Aspergillus fumigatus

Candida albicans

Micromonas pusilla

Enterocytozoon bieneusiEncephalitozoon intestinalis

Encephalitozoon romaleaeEncephalitozoon hellem

Encephalitozoon cuniculi MICROSPORIDIA

FUNGI(Ascomycetes)

FUNGI(Chytrids)

FUNGI(Basidiomycetes)

STREPTOPHYTAGREEN ALGAE

STRAMENOPILES

METAZOA

BACTERIA

0.96/-

1/801/100

0.2

1/96

1/96

0.81/-

1/99

1/-

1/97

1/98

1/100

1/96

0.92/-

0.91/-

1/100

0.98/85

1/72

0.93/-

1/100

1/88

1/89

1/100

0.92/-

0.93/-

0.91/-

1/89

1/100

1/88

1/93

1/99

1/920.98/81

0.93/84

Enterocytozoon bieneusi

Chlamydomonas reinhardtii shmt3

Populus trichocarpa shmt8

Neurospora crassa cyt

Tuber melanosporum

Glomerella graminicola

Arabidopsis thaliana shmt2

Thermobispora bispora

Saccharomyces cerevisiae

Chlamydomonas reinhardtii

Cavia porcellus cyt

Culex quinquefasciatus

Saccharomyces cerevisiae

Populus trichocarpa shmt3

Salmo salar mito

Sordaria macrospora

Bos taurus cyt

Aedes aegypti

Metarhizium anisopliae

Homo sapiens shmt2 mito

Phaeodactylum tricornutum

Xenopus tropicalis

Arabidopsis thaliana shmt3

Sporisorium reilianum

Neurospora crassa mito

Nodularia spumigena

Selaginella moellendorffii

Populus trichocarpa shmt1

Danio rerio cyt

Vitis vinifera mito

Citromicrobium bathyomarinum

Salpingoeca sp

Ustilago maydis

Glomerella graminicola

Glycine max mito

Bos taurus mito

Homo sapienscyt

Volvox carteri

Danio rerio mito

Oryza sativa mito

Tuber melanosporum

Oryza sativa mito

Chaetomium thermophilum

Chlamydomonas reinhardtii shmt2

Branchiostoma floridae

Desulfotalea psychrophila

Ectocarpus siliculosus

Melampsora larici

Phytophthora infestans mito

Coprinopsis cinereaMonosiga brevicollis

Micromonas pusilla

Hordeum vulgare

Gallus gallus cyt

Puccinia graminis

Phytophthora infestans shmt1 mito

Micromonas pusilla

Ectocarpus siliculosus

Populus trichocarpa shmt6

Lyngbya sp

Parasutterella excrementihominis

Encephalitozoon intestinalis

Encephalitozoon romaleaeEncephalitozoon hellem

Encephalitozoon cuniculi MICROSPORIDIA

FUNGI(Ascomycetes)

Mito.

Cyt.

STREPTOPHYTAGREEN ALGAE

STRAMENOPILES

METAZOA

Mito.

Cyt.

STREPTOPHYTAGREEN ALGAE

FUNGI(Basidiomycetes)

CHOANOFLAGELLATES

STRAMENOPILES

STREPTOPHYTA

BACTERIA

SHMT

0.2

1/95

1/99

0.98/-

1/100

1/100

1/-

1/100

1/74

1/99

1/100

1/-

1/100

0.98/- 1/100

1/100

0.94/-

1/90

1/76

1/99

0.84/-

1/85

1/100

1/971/99

1/76

1/100

1/96

1/100

1/99

0.99/-

1/100

1/-

0.97/84

1/92

1/97

0.83/-

1/100

1/100

1/70

0.99/-

1/100

1/100

1/94

1/96

0.83/-

0.89/84

1/83

1/92

1/98

1/100

0.87/93

1/97

1/100

1/100

1/100

1/95