Autoreactive CD4- CD8- ajpT cells to vaccinate adjuvant arthritis
Development of CD8 + T cells in the thymus
-
Upload
zelda-pierce -
Category
Documents
-
view
41 -
download
0
description
Transcript of Development of CD8 + T cells in the thymus
Development of CD8+ T cells in the thymus
Raine Toivonen
Double negative T cell
Lymphoidprogenitor
Double positive T cell
Cortical epithelialcell
Death byNeglect due toWeak signalling
CORTEXMEDULLA
CD8 committed T cell
CD4 committed T cell
THYMUS
Medullary epithelial cellOr
Dendritic cell
CD8 T cell
Negative selectionand death
Positiveselection
TO THEPERIPHERY!
Activation of CD8+ T cells in the periphery
Raine Toivonen
CD8+ T CELL
AgTCR
CD28
IL-2IL-2
IL2R
IL2R
CD8
Dendritic cell
MHC I
CD80 / CD86
• CD8+ T cell encounters an activated APC
• The APC presents antigen on its surface within MHC I
• Antigens can be bound to MHC I either when they are synthesized within the cell (endogenous or viral antigens) or transferred from phagosomes to cytosolic compartment (cross-presentation of exogenous antigens)
• CD8 T cell produces IL-2 to drive its own proliferation
The DC is activated by CD4+ T cell: license to kill
Raine Toivonen
CD8+ T CELL
AgTCR
CD8
IL12R
DENDRITIC CELL
MHC I Ag TCRCD4
CD28B7(CD80 / CD86)
CD4+ T HELPER CELL
CD40LCD40
CD28
Killing mechanisms1. Perforin/Granzymes
Raine Toivonen
Ag
CTL Infected cell
CASPASE
DNA
DISC
Killing mechanisms
Raine Toivonen
2. FAS / FAS ligand
Ag
CTL Infected cell
CASPASE 3
CASPASE 2
DAXXDAXX RIP1RIP1RAIDDRAIDD
APOPTOSIS
ASK1
JNKJNK
FAD
DFA
DD
ProCASPASE 8
CASPASE 8