Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.
-
Upload
rosalyn-cannon -
Category
Documents
-
view
224 -
download
2
Transcript of Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.
![Page 1: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/1.jpg)
Developing a Cardiovascular Model
James ClearChase HoughtonMeghan Murphy
![Page 2: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/2.jpg)
Problem Statement
• No all-purpose cardiovascular model is currently commercially available. – Models are made for testing of a particular device
exclusively– No in vitro model exists for physicians to learn and
visualize cardiac procedures• Current model exists from last semester but
has design flaws and performance shortcomings
![Page 3: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/3.jpg)
Problem Statement: Current Devices
• Patented model for fatigue testing of prosthetic tricuspid valve replacements. Model applies pressure on valve to mimic in vivo forward and backflow gradients.
• Agar gel model with characteristics of biological tissue used to model left ventricular and aortic chambers. Ultrasound imaged flow dynamics through bicuspid valve.
• Model testing ventricle assist devices pumping performance and quantifying flow dynamics. Resistance comparable to native heart present.
• Patented teaching model for complex cardiac surgery including repair of congenital heart defects. Clay open system model with detachable colored tubes.
![Page 4: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/4.jpg)
Previous Design
Design flaws to be addressed: Not easily drained, model leaks, heart itself is not anatomically correct, not portable, no flow gradient
Leaking joints
Anatomically incorrect heart
Size and weight of base- not portable
Emptied by lifting model
![Page 5: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/5.jpg)
Primary Objective
It is the purpose of this team to use the previously established model as a foundation for developing a heart model of the inferior venous flow for testing intracardiac procedures including stent and catheter delivery.
![Page 6: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/6.jpg)
Specific Device Objectives
• Our device has been designed to:• Demonstrate catheters used as optical scopes in the
heart– Proof of concept for this scope device for potential investors
• Demonstrate Swan-Ganz catheters used to measure blood pressure in the heart– Perform right heart catheterization- measure pressures in the
heart
• Demonstrate catheter delivery to intended site using sail on catheter tip– Illustrated in model by water flow under pump generated
pressure gradient
![Page 7: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/7.jpg)
Solution Description: Adaptations to Current Design
• Remove upper half – decrease size, increase portability• Connect metering bellows pump to simulate blood
flow through veins – Flow rate: 1.6 L/min– Pressure gradient: .2 psi
• Acrylic tubing – can withstand high impact stress, high clarity
• Acrylic dichloroethylene glue – welding joints • Multiple catheter access points– for entry of catheter
and prevent back flow, collecting basin for any water loss
![Page 8: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/8.jpg)
Adapting Current Model
![Page 9: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/9.jpg)
Device Functions and Specs
• Visualize catheter movement through device – high clarity acrylic tubing
• Water tight venous system– acrylic dicholoethylene glue
• Anatomically correct venous flow– Metering bellows pump-:.2 psi, 1.6 L/min
• Anatomically correct heart– Casted with clear flexible urethane
• Fit inside carry on luggage– 22” x 14” x 9”
![Page 10: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/10.jpg)
Model Design
www.cvcu.com.au/images/cv_torso.jpg
![Page 11: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/11.jpg)
Progress & Future Direction
• Make final 180 degree turns
• Manufacture modular Y-shaped connector with O-rings
• Explore casting with polyester resin to improve clarity
• Attempt manufacturing bored acrylic 4in sphere
2.5 in bend diameter
4 in
![Page 12: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/12.jpg)
Heart Model Directions
~4 in diameter sphere
v= ~90mlv= ~30ml
Bored Acrylic Sphere Concept: Casting Acrylic Mold Attempt:
![Page 13: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/13.jpg)
Validation
• Performance will be assessed by how physicians interface with device and how realistically the device models cardiac procedures
• Conclusions will be drawn on how the design implements intended design features– Portable, Transparent, Pump, Water-tight
• Physician input will be considered for future design improvements and used to identify drawbacks
![Page 14: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/14.jpg)
Physician Specific Validation
• Does the model visibly demonstrate optical scope catheter use into the heart?
• Does the model demonstrate Swan-Ganz catheter use in the heart?– Is it possible to measure pressures in the heart (perform
right heart catheterization)?
• When catheter delivery is demonstrated, is it clear to observers what structures the model replicates?
![Page 15: Developing a Cardiovascular Model James Clear Chase Houghton Meghan Murphy.](https://reader036.fdocuments.net/reader036/viewer/2022062515/56649d1f5503460f949f28b7/html5/thumbnails/15.jpg)
References
• Appartus for Testing Prosthetic Heart Valve Hinge Mechanism. More RB et al., inventors. United States Patent US5531094. http://www.freepatentsonline.com/5531094.pdf accessed 12 Nov 2009.
• Durand LG, Garcia D, Sakr F, et al. A New Flow Model for Doppler Ultrasound Study of Prosthetic Heart Valves. Journal of Heart Valve Disease. [Internet] 2006 Nov 4 [cited 12 November 2009]; 17. Available from: http://www.icr-heart.com/journal/.
• Hertzberg BS, Kliewer Ma, Delong DM et al. Sonographic Assessment of Lower Limb Vein Diameters: Implications for the Diagnosis and Characterization of Deep Venous Thrombosis. AJR. May 1997; 168:1253-1257.
• Pantalos GM, Koenig SC, Gillar KJ, Giridharan GA, Ewert DL. Characterization of an adult mock circulation for testing cardiac support devices. ASAIO. Feb 2004; 50(1):37-46.
• Pediatric congenital heart defect model. United States Patent US7083418. http://www.patentstorm.us/patents/7083418/description.html accessed 12 Nov 2009.
• Replogle RL, Meiselman HJ, Merrill EW et al. Clinical Implications of Blood Rheology Studies. Circulation 1967; 36:148-160.