Derivatii benzopiranului
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Transcript of Derivatii benzopiranului
DERIVAII 1,2- I 1,4-BENZOPIRANULUI
(-piran 1,2-benzopiran (-piran 1,4-benzopiran
(-piron cumarin (-piron (- cromon
(benzo-(-piron) (benzo-(-piron)
tetrahidropiran croman
flavan flavon (2-fenilcroman) (2-fenil-(-cromon)
Clasificarea medicamentelor
derivai ai benzopiranului1. Derivaii 4-hidroxicumarinei (cumarina) anticoagulani:
2. Derivaii cromanului tocoferolii (vitaminele grupei ):
croman (benzo-(-dihidropiran)3. Derivaii fenilcromanului flavanoidele (vitaminele grupei ):
4. Derivaii benzo-(-pironei astm bronic:
Aethylis biscoumacetas
Etil biscomacetat NeodicumarinumEsterul etilic a acidului bis (4-hidroxi-cumarinil-3)-aceticAcenocumarolum
Acenocumarol Syncumar4 hidroxi - 3-[1-(4-nitrofenil)-3oxo-butil]-2H-1-benzopiran-2onWarfarinum Warfarin 3-((-acetonilbenzil)-4-hidroxicumarin
cumarin 4-hidroxicumarin dicumarin
Obinerea etil-biscumacetatului (neodicumarin):
4-hidroxicumarina Esterul etilic
a acidului glioxilicObinerea acenocumarolului:
4-hidroxicumarina p-nitrobenziliden- acenocumarol
acetonObinerea warfarinei:
Identificarea: Dup spectrele n IR i UV;
Calcinarea cu alcali:
n condiii mai blnde:
cumarin Cu H2SO4 (conc) etilbiscumacetatul d o coloraie galben ce vireaz n portocaliu. La diluarea cu ap se obine un precipitat alb:
Acidul bis-(4-hidroxicumarinil-3)-aceticCu soluie de amoniac - se formeaz o soluie incolor, iar la adugarea hidroxidului de sodiu culoare galben - pal; Obinerea iodoformului (gruparea etoxi); Cu clorur de fier (III) n mediu alcoolic la nclzire se obine o coloraie ro-brun; Cu anhidrida acetic se formeaz precipitat:
etilbiscumacetat
Diacetat-etilbiscumacetat Reacia de obinere a azocolorantului:
Ureea se adaug pentru descompunerea excesului de nitrit de sodiu:
Dozarea:
Derivaii indanului
indan indandion-1,3 cumarin Phenindionum
Fenindion
Fenilin
2-fenilindandionObinerea:
Anhidrida ftalic ftalid 2-fenilindandion-1,3
Sarea sodic a 2-fenilindandion-1,3 fenindionIdentificarea: Cu soluie de NaOH se formeaz un precipitat rou: Cu H2SO4 (conc) coloraie albastru-violet, care la adugarea apei, soluia devine incolor i cade un precipitat alb.Dozarea: Metoda de neutralizare. Punctul de echivalen se stabilete poteniometric:
Metoda bromatometric:
Derivaii benzo --pironei
benzo--piron 2-carboxi-5-hidroxi- -cromon
(-cromon)
Acidum cromoglicicum
Acid cromoglicic
Sodium cromoglycate
Intal
1,3-bis-(2-carboxicromenil-5-hidroxi)-2-hidroxipropanObinerea:Identificarea:
Dup spectrele n IR i UV; Cu 4-aminoantipirin coloraie galben intens;Dozarea:
Titrarea n mediu anhidru; Metoda spectrofotometric.ocoferolii (vitaminele grupei E)
-piran croman (benzo--dihidropiran)
tocol sau (2-metil-2-(4', 8', 12'-trimetiltridecil)-6-hidroxicroman)
Poziia gruprilor metilice n molecula tocoferolilorocoferoliiPoziia
Activitatea biologic, %
, %
578
-tocoferol--3-3100
-tocoferol---40-50
-tocoferol---8
-tocoferol--3-80
8-metiltocol (-tocoferol)--~31
5-metiltocol (-tocoferol)---1
7-metiltocol (-tocoferol)---1
Obinerea:
trimetilhidrochinona izofitol
-tocoferol -tocoferol acetatTocopheroli acetas
Acetat de tocoferol
Acetat de 2,5,7,8-tetrametil-2-(4(,8(,12(-trimetiltridecil)-6-il racemicIdentificarea
-tocoferilchinona
(coloraie roie-portocalie) colorant azinic
bis--tocoferon bis--tocoferol
tocoferilchinona (coloraie galben)
,-dipiridDozarea:
difenilamina sarea de imoniu a difenilbenzidineiFlavanoide (vitaminele grupei )
(polifenoli)
croman flavan flavon
(dihidrobenzo--piran) (2-fenilcroman) (2-fenil-(-cromon)
quercitinRutozidum Rutozid
Rutin 3-rutinozida qvercetinei ori 3-ramnoglicozil-3,5,7,3(,4(-pentahidroxiflavanonTroxerutinum Troxerutin
Troxevasinamestec 3(, 4( i 7-((-hidroxietil)-rutozideObinerea:
rutozida -acetobromrutinaza
.
rutozida halcon (coloraie galben-portocalie)
rutozida cromenol
cianinclorur
(coloraie roie) EMBED ISISServer
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