Department of Radiology University of Kentucky MEDICAL ... Facilities Brochure.pdf• Radiology...

Department of Radiology University of Kentucky

MEDICAL IMAGING TECHNOLOGIES and RESOURCES for

RESEARCH

Peter Hardy, PhD Assistant Professor and Director of Research

M. Elizabeth Oates, MD

Professor and Chair

M. Denise Quandt, MAS Administrator

July 2014 - June 2015

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I. Introduction A. Overview

• The Department of Radiology promotes human subject research through its state-of-the-art medical imaging facilities distributed across the Chandler Medical Center campus.

• This document provides essential information regarding the many imaging technologies available for human research.

• This information is designed to guide you in planning and accessing these resources as you develop your research projects and budgets.

• Additional information about the Department of Radiology’s research activities may be found at http://radiology.med.uky.edu.

B. Guiding Principles

• All diagnostic medical imaging related to human clinical research in the Department of Radiology is performed by staff technologists operating under the direction of their respective Radiology faculty physicians and physicists.

• All image-guided interventional procedures are performed by specialized Radiology faculty physicians.

• Professional recognition and salary support of Radiology personnel commensurate with their effort, expertise, and oversight are expected.

• All research protocols must be approved by the UK Institutional Review Board (IRB). • Additional approvals may be necessary depending upon the nature of the research. • Special accommodations may be made for selected animal imaging research.

C. Personnel Resources

• The UK Department of Radiology has more than 40 physician faculty, two physicist faculty, and more than 150 staff technologists.

• All physician and physicist faculty are board-certified or are in the process of achieving board certification.

• All staff technologists have received, or are in the process of receiving, modality-specific certification and licensure.

D. Hours of Operation

• Vary for different modalities, but in general Monday-Friday, 7:30 am – 5:00 pm. • For human research, off-hours arrangements may be available. • For animal research, off-hours arrangements must be made.

E. Costs

• The professional fee for a given imaging examination or interventional procedure is determined by UK HealthCare as a percentage of the usual and customary clinical charge; this fee may be waived if faculty salary support is included within the project budget.

• The hospital charge for a given imaging examination or interventional procedure is determined by UK HealthCare in negotiation with the NIH as a percentage of the usual and customary clinical charge.

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• As these charges change annually, investigators should contact the Radiology Senior Research Coordinator to discuss their particular research needs for initial and renewal budgets. When developing a budget for a grant proposal, investigators are encouraged to anticipate increases in these charges in future fiscal years.

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F. Contact Information

• To learn about the administrative and financial aspects of radiologic research or to arrange a tour of our facilities:

L. Joyce McCown Senior Research Coordinator, Department of Radiology Email: [email protected] Office: 323-1823

• To discuss your proposed project, its technical and personnel requirements, and be directed to the appropriate Radiology personnel:

Peter A. Hardy, PhD Director of Research, Department of Radiology

Email: [email protected] Office: 323-2703 Pager: 330-0185

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mailto:[email protected]

II. Computed Tomography (CT) Imaging A. Overview

• A CT scanner uses ionizing radiation (x-rays) to create high-resolution three-dimensional tomographic images (“slices”) of any part of the human anatomy from head to toe.

• Oral and/or intravenous iodinated contrast media may be given to enhance normal anatomy and delineate pathology.

B. Facilities, Technical Capabilities & Limitations • There are four CT scanners available for human research. • All scanners produce high-quality digital images. • Images are viewable and archived on the Enterprise-wide McKesson PACS; CDs/DVDs

can be created as needed. • Radiology reports are viewable through SCM/AEHR and can be printed as needed.

Unit Location Type Number of Detectors (“Slices”)

Table Weight Limits (Kg)

Bore Diameter

(cm)

1 Second Floor, Chandler Hospital,

Pavilion H

Siemens Somatom Sensation OPEN 40 40 279 80

2 Siemens Somatom Definition AS 40 40 220 78

3 Ground Floor, Gill Imaging

Center, Pavilion G

Siemens Somatom Definition AS 64 220 70

4 Siemens Somatom Definition, Dual Energy 64 300 70

Figure 1: Siemens Somatom Definition, Dual Energy

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C. Hours of Operation • Monday – Friday, 7:30 am – 5:00 pm. • Other days/times by arrangement.

D. Personnel Resources

• American Board of Radiology-certified, subspecialized Radiology Physicians (MDs). • American Board of Radiology-certified Medical Physicist (PhD). • American Registry of Radiologic Technologists (ARRT)-certified Radiology

Technologists with subspecialty certification in CT.

E. Costs • Please discuss project and all applicable costs with Radiology Senior Research

Coordinator prior to IRB and/or grant submission or renewal. • Radiology costs include the technologist’s time to prepare and image the patient/human

research subject according to protocol, process the image data, and archive the images to a CD/DVD if required by the investigator or study sponsor.

• Supply costs might be incurred, e.g., contrast media. • Professional services by radiology physicians and/or medical physicists are negotiable.

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III. Dual Energy X-ray Absorptiometry (DEXA)/Bone Mineral Density (BMD) Imaging A. Overview

• A DEXA scanner uses low-level x-rays to measure bone mineral density (BMD) of the lumbar spine, hip, and/or forearm, typically for the diagnosis and monitoring of osteoporosis.

• A DEXA scanner can measure whole-body tissue composition.

B. Facilities, Technical Capabilities & Limitations • In Radiology, there is one DEXA scanner available for human research. • The scanner produces high-quality digital images. • Images are viewable and archived on the Enterprise-wide McKesson PACS; CDs/DVDs


Unit Location Type Table Weight Limit (Kg)

1 First Floor, Kentucky Clinic (KYC) Hologic Discovery A 200

C. Hours of Operation

• Monday – Friday, 7:30 am – 4:30 pm. • Other days/times by arrangement.

Figure 2: Hologic Discovery A

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D. Personnel Resources • American Board of Radiology and/or American Board of Nuclear Medicine-certified,

subspecialized Radiology Physicians (MDs). • American Board of Radiology-certified Medical Physicist (PhD). • American Registry of Radiologic Technologists (ARRT)-certified Radiology

Technologists with subspecialty certification in Bone Densitometry.




• Supply costs might be incurred, e.g., CDs/DVDs. • Professional services by radiology physicians and/or medical physicists are negotiable.

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IV. Fluoroscopic Imaging A. Overview

• Fluoroscopy uses ionizing radiation (x-rays) to observe any part of the human anatomy from head to toe in real-time.

• Barium and/or iodinated contrast media may be given to enhance normal anatomy and physiology and to delineate pathology and pathophysiology.

B. Facilities, Technical Capabilities & Limitations • There are two fluoroscopy units available for human research. • All units produce high-quality digital images including video (cinematic) loops. • Images are viewable and archived on the Enterprise-wide McKesson PACS; CDs/DVDs


Unit Location Type Table Weight Limits (Kg)


Pavilion H

Siemens Luminos Agile 275

2 Siemens Axiom Sireskop 136 C. Hours of Operation


Figure 3: Siemens Luminos Agile

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D. Personnel Resources • American Board of Radiology-certified, subspecialized Radiology Physicians (MDs). • American Board of Radiology-certified Medical Physicist (PhD). • American Registry of Radiologic Technologists (ARRT)-certified Radiology

Technologists.




• Supply costs might be incurred, e.g., barium and/or iodinated contrast media. • Professional services by radiology physicians and/or medical physicists are negotiable.

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V. Mammographic Imaging A. Overview

• Mammography uses ionizing radiation (x-rays) to create images of different tissue characteristics in the human breast.

• Mammography can detect breast cancer.

B. Facilities, Technical Capabilities & Limitations • There are three mammography units available for human research. • All units are capable of tomosynthesis (“image slices”). • All units produce high-quality digital images. • Images are viewable on Hologic SecurView workstations and archived on Enterprise-

wide McKesson PACS; CDs/DVDs can be created as needed. • Radiology reports are created in MagView, viewable through SCM/AEHR, and can be

printed as needed.

Units Location Type

3

Second Floor, Whitney-Hendrickson

Building (Pavilion WH)

Hologic Selenia Dimensions Mammography (DBT)

(Tomosynthesis capable)

Figure 4: Hologic Selenia Dimensions Mammography (DBT)

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Technologists with subspecialty certification in Mammography.





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VI. Magnetic Resonance Imaging (MRI) A. Overview

• MRI uses strong magnetic fields and radiowaves, not x-rays, to create high-contrast three-dimensional tomographic images (“slices”) of any part of the human anatomy from head to toe.

• Intravenous gadolinium-based contrast media may be given to enhance normal anatomy and delineate pathology.

• MRI may be conducted safely in most volunteers, children, and pregnant women and may be repeated without risk.

• Imaging in patients with metal (e.g., pacemaker) is generally contraindicated.

B. Facilities, Technical Capabilities & Limitations • There are five MR scanners available for human research. • All scanners are high-field, superconducting systems with different capabilities. • All units produce high-quality digital images. • Images are viewable and archived on the Enterprise-wide McKesson PACS; CDs/DVDs


Unit Location Type Field

Strength (T)

Special Clinical

Applications

Table Weight (Kg)

Bore Size (cm)

1 First Floor, Chandler Hospital,

Pavilion H

Siemens Symphony 1.5 Pediatrics

(sedation) 200 60

2 Siemens 1.5 200 60

Figure 5: Siemens Verio

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Symphony

3 Ground Floor,

Gill Imaging Center,

Pavilion G

Siemens Aera 1.5 Heart 250 70

4 Siemens Verio 3.0 Bones & joints;

Brain & spine 250 70

5

First Floor, Kentucky

Clinic (KYC)

Siemens Espree 1.5 Breast 250 70




• American Board of Radiology-certified, subspecialized Radiology Physicians (MDs). • American Board of Medical Physics-eligible Medical Physicist (PhD). • American Registry of Radiologic Technologists (ARRT)-certified Radiology

Technologists with subspecialty certification in MRI.




• Supply costs might be incurred, e.g., contrast media. • Professional services by radiology physicians and/or medical physicists are negotiable.

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VII. Nuclear Medicine A. Overview

• Nuclear Medicine uses gamma rays (a form of ionizing radiation similar to x-rays) emitted from a wide variety of radiopharmaceuticals to create images of the entire body from head to toe.

• The biodistribution pattern reflects normal physiology or underlying pathophysiology. • The radiopharmaceuticals may be administered intravenously, orally, or by other routes.

B. Facilities, Technical Capabilities & Limitations

• There are three gamma camera units available for human research. • All are capable of performing Single Photon Emission Computed Tomography (SPECT)

(“slices”). • All units produce high-quality digital images. • There is one co-located thyroid probe available for human research. • Images are viewable and archived on the Enterprise-wide McKesson PACS; CDs/DVDs



1 Ground Floor,

Chandler Hospital, Pavilion H

Siemens Symbia S 227

2 Siemens Signature E Cam 180

3 Siemens Symbia S 200

Figure 6: Siemens Symbia S

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• American Board of Radiology and/or American Board of Nuclear Medicine-certified, subspecialized Radiology Physicians (MDs) who are Authorized Users of Radioactive Materials for Human Use.

• At least one of the Department of Radiology’s Authorized Users of Radioactive Materials must be named as a Co-Investigator.

• American Board of Radiology-certified Medical Physicist (PhD). • Nuclear Medicine Technology Certification Board (NMTCB)-certified Nuclear Medicine

Technologists.




• Supply costs might be incurred, e.g., radiopharmaceuticals. • Professional services by radiology physicians and/or medical physicists are negotiable.

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VIII. Positron Emission Tomography (PET) A. Overview

• PET uses ionizing radiation (like gamma rays) from positron-emitting radiopharmaceuticals to create three-dimensional tomographic images (“slices”) of the entire body from head to toe.

• The biodistribution pattern on PET reflects normal physiology or underlying pathophysiology; the CT scanner co-registers the anatomy to create fused images.

• The radiopharmaceutical is administered intravenously. • The service is through a contract with Alliance Imaging. • No sedation is available.


• There is one PET/CT scanner (PET scanner coupled to a CT scanner) available for human research.

• The unit produces high-quality digital images. • Patients/human research subjects are received inside W-H where bathrooms are available. • Radiopharmaceuticals are administered inside the coach. • Any 18F-labeled radiopharmaceutical that arrives in a ready-to-inject form can be

administered to the patient/research subject and later imaged. • Currently, the site’s radioactive materials license allows only for 18F-labeled

radiopharmaceuticals; use of 124I and 68Ga radiolabeled compounds requires license amendment.

• Use of non-Food and Drug Administration (FDA)-approved radiopharmaceuticals require UK IRB approval.

• Images are viewable and archived on the Enterprise-wide McKesson PACS; CDs/DVDs can be created as needed.

• Radiology reports are viewable through SCM/AEHR and can be printed as needed.

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Bore Size (cm)

1

Coach outside Whitney-Hendrickson

Building, Pavilion WH

Siemens Biograph TruPoint with Lutetium Oxyorthosilicate (LSO) crystals & 6-slice CT

400 70




• American Board of Radiology and/or American Board of Nuclear Medicine-certified, subspecialized Radiology Physicians (MDs) who are Authorized Users of Radioactive Materials for Human Use.

• At least one of the Department of Radiology’s Authorized Users of Radioactive Materials must be named as a Co-Investigator.

• American Board of Radiology-certified Medical Physicist (PhD). • Nuclear Medicine Technology Certification Board (NMTCB)-certified Nuclear Medicine

Technologists.

E. Costs • The service is through a contract with Alliance Imaging. • Please discuss project and all applicable costs with Radiology Senior Research



• Supply costs might be incurred, e.g., radiopharmaceuticals. • Professional services by radiology physicians and/or medical physicists are negotiable.

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IX. Radiographic Imaging (“X-Rays”)

A. Overview • Radiography uses ionizing radiation (x-rays) to image any part of the human anatomy

from head to toe. • This technique is well-suited to the skeleton.


• There are six radiography (x-ray) units available for human research. • All units produce high-quality digital images. • Images are viewable and archived on the Enterprise-wide McKesson PACS; CDs/DVDs



1 Second Floor,


Siemens Luminos Agile 275

2

First Floor, Kentucky Clinic

(KYC)

SwissRay Multi DR

225

3 4 5 SwissRay Modulaire Plus

6 SwissRay Formula DR

Figure 9: SwissRay Formula DR

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Technologists.




• Supply costs might be incurred, e.g., CDs, DVDs • Professional services by radiology physicians and/or medical physicists are negotiable.

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X. Ultrasound Imaging

A. Overview • Ultrasound uses high-frequency sound waves (not ionizing radiation, not x-rays) to create

high-resolution three-dimensional tomographic images (“slices”) of any part of the human anatomy from head to toe.

• Ultrasound may be conducted safely in most volunteers, children, and pregnant women and may be repeated without risk.

B. Facilities, Technical Capabilities & Limitations • There are three ultrasound units equipped with different frequency linear-array and

phased-array transducers available for human research. • All units produce high-quality digital images. • Images are viewable and archived on the Enterprise-wide McKesson PACS; CDs/DVDs


Unit Location Type

1 Second Floor,


Philips iU22 2

3

Figure 10: Philips iU22

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• American Board of Radiology-certified, subspecialized Radiology Physicians (MDs). • American Board of Radiology-certified Medical Physicist (PhD). • American Registry for Diagnostic Medical Sonographers (ARDMS)-certified Ultrasound

Technologists with subspecialty certification in Ultrasound.





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XI. Vascular & Non-Vascular Interventional Radiology Procedures A. Overview

• Using fluoroscopy, radiologists perform image-guided vascular and non-vascular interventional procedures on the entire body from head to toe.

• Using computed tomography (CT) and ultrasound, radiologists perform image-guided non-vascular interventional procedures on the entire body from head to toe.

B. Facilities, Technical Capabilities & Limitations • There are four angiographic fluoroscopy suites for endovascular, biliary, urinary and

other non-vascular interventions available for human research. • There are two CT scanners used for non-vascular interventions (e.g., biopsies) available

for human research. • All units produce high-quality digital images. • Images are viewable and archived on the Enterprise-wide McKesson PACS; CDs/DVDs



1 Third Floor, Chandler Hospital,

Pavilion H

Siemens Axiom Artis Zee Biplane 200 2 Siemens Axiom Artis Single Plane 200 3 Siemens Axiom Artis Single Plane 200 4 Siemens Axiom Artis Single Plane 170

Figure 11: Siemens Axiom Artis Zee Biplane

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Unit Location Type Number of Detectors (“Slices”)

Table Weight Limits (Kg)

Bore Diameter

(cm)


Pavilion H

Siemens Somatom Sensation OPEN 40 40 279 80

2 Siemens Somatom Definition AS 40 40 220 78





Technologists with subspecialty certification in Interventional Radiology or Computed Tomography.




• Supply costs might be incurred, e.g., contrast media, catheters. • Professional services by radiology physicians and/or medical physicists are negotiable.

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