DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE …DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED...
Transcript of DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE …DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED...
21.06.18
1
1
T. H. Helbich Department of Biomedical Imaging and Image-guided Therapy
Division of Molecular and Gender Imaging
Medical University of Vienna
Tumor Imaging: From Morphology to Molecules
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
CancerImages:MORPHOLOGY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
Goal for 2030
molecularimagingcellular,molecularlevel
conventionalradiologymacroscopic-anatomicallevel
1x109
- Detect CA earlier - Reduce overdiagnosis - Treat earlier & better
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
Metastasis [18F]FDG PET DWIBS Bone Scan CT/MRI
Angiogenesis CE-MRI qBOLD VAM Proliferation
[18F]FLT PET, MRSI, DWI
Cell Death PET MRS Hyperpolarized MRI
Altered Metabolism
[18F]FDG PET MRSI Hyperpolarized MRI [18F] MISO PET CEST
Hanahan D. et al. Cell 2011;144:646-74.
HALLMARKS&NON-invasiveIMAGING
• One tumor sample has 100 mutations on every human gene • 10 underlining CA principles (15.000 citations)
21.06.18
2
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
MultiparametricMRIincancers
DCE-MRI morphology &
neoangiogenesis
1H-MRSI metabolism
DWI microstructural
changes Red
uctiono
fbiopsie
s50%
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
MRI of Tumor Oxygenation
• 9.4 Tesla • Measures oxygen metabolism • in BLOOD & TISSUE • Oxygen inhalation • Correlation with HIF-1α
(hypoxia induced factor 1α)
Poster#A74
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
• Endogenous CEST:
• Gac-CEST (Glycosaminoglycan) • Amide-CEST (ATP) • Amine-CEST • aaa-CEST (aliphatic) • Hydroxyl-CEST • Glu-CEST • Gluco-CEST
Emerging techniques: Chemical Exchange Saturation Transfer (CEST)
80mM
40mM
20mM
10mM
0mM
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
Emerging techniques for Metabolism: Hyperpolarized(HP)MRSI
• HP MRSI allows rapid, radiation-free, non-invasive investigation of tumor metabolism using hyperpolarized exogenous probes e.g 13C
• Hyperpolarization results in an extensive increase in signal intensity, e.g 13C >50,000 fold at 3T
Smallflame Wildlandfire
21.06.18
3
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
Emerging techniques: Hyperpolarized(HP)MRSI
• HP 13C probes injected into living systems
• HP 13C pyruvate incorporated into cell and metabolized
• Conversion of pyruvate to lactate measured with chemical shift imaging
Mignionetal.,2013Xuetal.,2013Xuetal.,2014Butteta.,2015
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
Nanoparticle Imaging
• Vehicles used: • Cell tracking • Multimodal contrast agents (MRI / PET / Optic) • Treatment (loading with DRUG)
HRSM:2016-2020:5,7MIll
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
MOLECULARMPHYBRIDMRI • Improves:
– Detection
– Characterization
– Staging
– Therapy monitoring
– Overdiagnosis
Tailored therapy
DWI NANO
CESTMRIPatients will acknowledge our efforts implementing personalized medicine
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
DEPARTMENT OF BIOMEDICAL IMAGING AND IMAGE-GUIDED THERAPY
HRSM-Fund:NANOBILD
Consortium:
PI: Helbich & Hacker
CoPI:
E. Reimhult BOKU
M. Ogris UW
5.7 Mill €
AIM: NANOBILD Development of multimodal
Contrast agents