Dental Pharmacology
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Transcript of Dental Pharmacology
DENTAL PHARMACOLOGY DENTIFRICES
Dentifrices are therapeutic aids meant for cleaning the teeth with the help of a toothbrush.
They are available in the form of powders, liquids and paste.
E.g: toothpaste and tooth powders In addition of certain sub. like fluoride and
antiseptics for the medical purpose. The ingredients are:1.Abrasive agents: To assist the scouring action of the toothbrush They are inorganic salts of low solubility
ABRASIVE AGENTS
E.g. prepared chalk, calcium phosphate, calcium and magnesium carbonate, magnesium oxide, ferric oxide, charcoal, kaolin etc
The abrasive powder should be fine to avoid scratching of the teeth surfaces.
Uses: Polishing the teeth and filling Cleaning the teeth
DETERGENTS
Detergents are cleansing agents which act by;
(i) Lowering surface tension.(possess emulsifying properties)
(ii)Dissolving fatty sub. and mucus plaques(iii)Foaming--- on scrubbing the teeth,
detergents foam and act as lubricants(iv)Loosening the debris adhering to the teeth(v)Some of them also liberate oxygen and have
antiseptic properties Thus detergents act as deodorants E.g. sodium lauryl sulphate and soaps.
3.ANTISEPTICS
The small amount of antiseptic used in dentifrices may not be sufficient to afford adequate antiseptic action.
Antiseptic used in dentistry are thymol, menthol, eugenol, benzoic acid, boric acid etc.
Thymol is a powerful antiseptic and a deodorant used in mouthwashes and gargles.
Eugenol has the odour of clove and is also a local anaesthetic commonly used for dental filling.
4.SWEETENING AGENTS These are sub. used to impart a sweet taste
to a preparation They are used to make the preparation more
pleasant and acceptable. Saccharine sodium is commonly used in
tooth powders It is an artificial sugar 500 times sweeter
than sugar. It has no caloric value and is excreted
unchanged with in 24 hrs. It is stable and nontoxic Sucrose not used --- it causes fermentation
5.COLOURING AGENTS
It is used to make the preparation more attractive for commercial purpose.
Liquor rubi imparts cherry red colour Methylene blue gives blue colour Chlorophyll gives green colour Most colours used commercially are
synthetically produced Some of them may also be obtained from
natural sources like plants, animals or minarals
6.FLAVOURING AGENTS
Flavouring agents are sub. used to impart a pleasant smell and taste to the preparation.
So it is more palatable Generally fruity and spicy flavours are
preferred. Natural flavours--- peppermint, lemon, mint
and pineapple. Synthetic flavours--- alcohol, aldehydes,
esters and fatty acids
7.OTHERS
Other agents used in dentifrices include(1) Binds agents like mucilage of tragacanth,
gum acacia and bentonite. They help to bind the liquid and solid
phases together in a paste.(2) Humectants like glycerin and sorbitol
prevent drying up of the paste.(3) Antacids like NaHCo3, neutralize acidity in
the oral cavity. A good dentifrice should be pleasant in taste,
odour and consistency. Should not damage the gums or teeth
OBTUNDENTS These are agents that diminish dentine
sensitivity. They are used to make the excavation
painless. Obtundents act by one of the following
mechanism:(1)Paralysing the sensory nerves: E.g.
phenol, menthol, thymol, clove oil, camphor, benzyl alcohol.
(2)Precipitating proteins: Astringents like stannous chloride, silver nitrate, zinc oxide and zinc chloride, paraformaldehyde
(3)Destruction of nervous tissue: e.g. absolute alcohol.
OBTUNDENTS
The dis.adv with the use of obtundents are, pulp may shrink and irritants may stimulate the formation of secondary dentine.
After the advent of local anaesthetics, the use of obtundents has declined.
MUMMIFYING AGENTS
Agents used to harden and dry the tissues of the pulp are called mummifying agents
This hardening makes the tissues resistant to infection
Astringents and antiseptic are used in combination as a paste for this purpose
E.g.:(1)Liquid formaldehyde: It is used with zinc
oxide and glycerin to harden the tissues(2)Paraform: Acts by slow release of
formaldehyde and is used in combination with zinc oxide and glycerine
MUMMIFYING AGENTS
(3) Iodoform: Acts by liberation of iodine. It is made into a paste with eugenol, phenol, tannic acid and glycerol for use in dental practice
(4) Tannic acid: It is an astringent, precipitates protein and hardens the tissues. The tissues may also shrink
DISCLOSING AGENTS
Dental plaques are relatively invisible. Certain agents (dyes) and iodine containing
solution may be used to make the supra-gingival plaques visible and such agents are called disclosing agents.
Dyes used as disclosing agents are:(1)Erythrosin Erythrosin tablets are dissolved into a
solutions or chewed to dissolve in the mouth It stains the plaques area red but also may
stain soft tissues It is the most widely used disclosing agent.
DISCLOSING AGENTS
(2) Fluorescein dye On application, it stains the plaque yellow It does not stain the soft tissues But special light is required to see the
stained plaque It is more expensive(3) Two-tone dyes A solution containing a combination of two
dyes is used Mature plaques are stained blue, while new
plaques are stained red
DISCLOSING AGENTS
Advantages: Dyes used as disclosing agents help to
differentiate mature and immature plaques They do not stain the gingival tissues(4) Iodine containing solution Iodine containing solution have been used as
disclosing agents but have the disadvantage of causing a high incidence of allergic reaction.
They also have an unacceptable taste Hence iodine solutions are not preferred
DISCLOSING AGENTS
Methods of application: To stain the plaque, solution of disclosing
agents may be used as follows:(1)Painting the teeth with a cotton swab(2)Rinsing the mouth(3)As tablet to be chewed dissolving it in the
saliva. The mouth should then be rinsed with water.