Tradeoff Analysis: From Science to Policy John M. Antle Department of Ag Econ & Econ
Denise Antle, ARNP, MSN, CCRN, CCNS Critical Care …mcrfmd.com/links/Antle-Cardiomyopathy1.pdf ·...
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Transcript of Denise Antle, ARNP, MSN, CCRN, CCNS Critical Care …mcrfmd.com/links/Antle-Cardiomyopathy1.pdf ·...
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Cardiomyopathy
Denise Antle, ARNP, MSN, CCRN, CCNSCritical Care ARNP/CNSGenesis Medical Center
Davenport, Iowa
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Objectives
Discuss the pathophysiology and etiologies of dilated, hypertrophic, and restrictive cardiomyopathyReview current medical and nursing management of patients with cardiomyopathyDiscuss future trends in management
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Cardiomyopathy
Irreversible primary, progressive disease of the heart muscle
Damage to the myocardial cells
Progressive deterioration
Predominant affect is on the myocardium
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Cardiomyopathy
“A diverse group of conditions whose final, common pathway is myocardial dysfunction”
Let’s talk!
WHO/ISFC classification: Based on pathophysiological features
Primary & Secondary: CM & Specific CM
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Etiology
1. Cardiovascular disease (remodeling)2. Infectious3. Toxins4. Systemic connective tissue diseases5. Infiltrative and proliferative diseases6. Nutritional deficiencies7. Idiopathic
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Classification
Arrhythmogenic Right Ventricular CM
Dilated
Hypertrophic
Restrictive
Unclassified CM
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Arrhythmogenic Right Ventricular Cardiomyopathy
Heart muscle disease characterized by replacement of the muscle by fibrous scar and fatty tissue. RV tends to be most affected.
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Arrhythmogenic Right Ventricular Cardiomyopathy
Symptoms early teens to second decadeEtiology unknown (familial). Incidence: 1:3000-10,000 Arrhythmia most prominentCHF, tricuspid regurgitationSymptoms
PalpitationsSyncopeFatigueHeart failureVentricular arrhythmias
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Arrhythmogenic Right Ventricular Cardiomyopathy
Antiarrhythmics – Amiodarone/SotololACEAnticoagulationDigoxinDiuretics
Arrhythmia most prominentCHF, tricuspid regurgitation, embolus
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Arrhythmogenic Right Ventricular Cardiomyopathy
Antiarrhythmics –Amiodarone/SotololACEAnticoagulationDigoxinDiuretics
CardioversionAblationPacemakerICDSurgery
Arrhythmia most prominentCHF, tricuspid regurgitation, embolus
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Dilated Cardiomyopathy (DCM)
EF less than 40% in the presence of increased LV dimensions
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Dilated Cardiomyopathy (DCM)
Cardiac enlargement
Hypertrophy?
Impaired systolicfunction of either or both ventricles
Dilation and impaired contraction
Apoptosis - necrosis - fibrosis
Laplace’s law
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Dilated Cardiomyopathy (DCM)
Most prominent CMIncidence – 36 cases/100,000 per year (Diagnostic criteria are lacking)Males and AfricansMiddle ageIDCM - accounts for 25% of all heart failure cases
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DCM: Etiologies
Primary - IdiopathicSecondary:Electrolyte abnormalitiesEndocrine abnormalitiesHypertension*Infectious causesInfiltrative diseasesIschemia*
Neuromuscular diseasesNutritional abnormalitiesRheumatologic diseasesTachyarrhythmiasToxinsValvular heart disease*
*WHO classified as specific cardiomyopathies
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Alcoholic Cardiomyopathy (DCM)
CHF, HTN, CVA, arrhythmia, sudden deathMajor cause of secondary, nonischemic CM
1/3 of all cases
Three mechanismsdirect toxic effect of alcohol/metabolitesnutritional (thiamine)alcohol additives (cobalt)
Men 30-55 years of age >10 year consumption
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DCM: Clinical Presentation
Fatigue/weaknessWeight lossDyspnea on exertionPeripheral edemaBP
Pulsus alternansPulsatile jugular veinsApical displacementS3 / S4Murmurs
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DCM: Clinical Presentation
OrthopneaPNDChest painAbdominal painEmboliDysrhythmiasSyncopeSudden death
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DCM: Diagnostic Tests
CXR - enlargementEKG - tachyarrhythmias, Q waves, R-waveEchocardiography - diffuse global dysfunction. (MV?)Catheterization
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Dilated Cardiomyopathy (DCM)
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DCM: Management
Sodium restrictionVasodilators (arterial/venous)ACE, ARBBeta-BlockersCardioversion
Pacemakers DiureticsAnticoagulationAntiarrhythmics (amiodarone)Heart transplant
Adrenergic and renin-angiotensin systems
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Hypertrophic Cardiomyopathy
Stiffness of the LV with resultant impaired ventricular filling
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Hypertrophic Cardiomyopathy
Myocardial mass
Ventricular cavities
LV over RV
Atria
Heterogeneous
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Hypertrophic Cardiomyopathy
Disproportionate thickening of the of the intraventricular septum. Greater hypertrophy of the ventricular septum than of the ventricular chambers
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Hypertrophic Cardiomyopathy
Excessive thickening of the heart muscle. Myocardial disarray - normal alignment of muscle cells is absentAbnormalities of collagen deposition and altered contractile proteins in the myocytes (whole structure changes)Fibrosis – visible scarMyocardial ischemia - abnormal intramural coronary arteries
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Hypertrophic Cardiomyopathy
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Hypertrophic Cardiomyopathy
Rare genetic disease
IHSS - Idiopathic hypertrophic subaortic
stenosis
Asymmetric septal hypertrophy
Muscular subaortic stenosis
Aortic stenosisHypertension
HCM vs. physiological hypertrophy
HCM in the elderly
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Hypertrophic Cardiomyopathy
1. Hyperdynamic state –septal thickening
2. Diastolic dysfunction –thickened muscle usually contracts well but doesn’t relax. Higher pressures result to allow expansion for the inflow of blood.
3. Possible outflow obstruction (~25%): MV involvement
4. Myocardial ischemia
Systolic dysfunction(pump)
vs.Diastolic dysfunction
(fill)
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Need to differentiate systolic and diastolic dysfunction
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Hypertrophic Cardiomyopathy
Clinical ManifestationsMild to asymptomatic – screenings
Sudden death
Dyspnea – most common from diastolic dysfunction
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Hypertrophic Cardiomyopathy
Clinical Manifestations:Angina, fatigue, syncope, dysrhythmias (more common)
Palpitations, PND, CHF, dizziness (less common)
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Hypertrophic Cardiomyopathy
Clinical ManifestationsS4 / S3 may be heard with outflow obstructions as well as a systolic murmurVentricular arrhythmias – ¾ of patientsSVT – ¼ to ½ of patients. Less toleratedEP testing – limited predictive valueCXR – normal to cardiomegalySquat position
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Hypertrophic Cardiomyopathy
Echocardiogram – screening and diagnosisCardinal sign is LV hypertrophy of septum and anterolateral free wallVariability in hypertrophyDilated left atriumNormal to near-normal EFSeptum at least 1.3 to 1.5 times the thickness of the posterior wall (15 mm). Average finding is 20 mmOutflow tract obstructions; MV / pressure gradient changesDiastolic dysfunction
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R-wave in AVL >11mm;
R wave height in Lead I plus the S wave depth in Lead III > 25 mm
*S wave depth in V1 plus the height in V5 that exceeds 35 mm
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Hypertrophic Cardiomyopathy
Morbidity / MortalityMortality – 1%-3% per yearSome remain stable or improve. Clinical deterioration is slowSudden death – higher in children/ adolescentsPatients with gradients are more likely to deteriorateAtrial fibrillation – may lead to increase symptoms (LA dilation)LV dilation and dysfunction (DCM) occurs in 5-10%. Wall thinning and scar formation
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Hypertrophic Cardiomyopathy
HCM
No symptoms -No treatment
Mild symptoms -Drug treatment
Moderate / severe symptoms
Non-obstructive –Beta blockers Calcium antagonists (Diuretics)
Obstructive: Drug treatment, alcohol ablation, myectomy, pacemaker
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Restrictive Cardiomyopathy
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Restrictive Cardiomyopathy
Myocardium becomes rigid, noncompliantDiastolic dysfunctionVentricular fillingSystolic function preservedResembles constrictive pericarditisPrevalence: <5% of CM in western world
Restrictive pericarditis
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Restrictive Cardiomyopathy
IdiopathicNoninfiltrative: SclerodermaInfiltrative: Amyloidosis, SarcoidosisStorage Disease: HemochromatosisEndomyocardial: Metastatic cancers Radiation
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Restrictive Cardiomyopathy
Clinical heart failure –right failure prominentJVDS3, S4, or bothElevation in CVPPeripheral edema, liver enlargement, ascitesExercise intoleranceWeaknessDyspnea
AV blockSymptomatic bradycardiaAtrial fibrillation
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Restrictive Cardiomyopathy
CXRCT / MRIEchocardiogram – dilated atria, increased early LV filling velocity, decreased atrial filling velocity, and decreased isovolumetric relaxation timeEndomyocardial biopsy
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Restrictive Cardiomyopathy
No satisfactory medical therapy (treat secondary causes)Drug therapy must be used with caution:
Diuretics for extremely high filling pressuresVasodilators may decrease filling pressure?Calcium channel blockers to improve diastolic complianceDigitalis and other inotropic agents are not indicated
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Summary