Medical science applied to interactions between marketed medications and the populationComes from Greek:pharmacon (poison)epi (concerning)demos (people)logos (study) Farmako dan pidemiologi Farmako dan pidemiologi Farmakologi: studi mengenai efek tentang obatFarmakologi: studi mengenai efek tentang obatFarmakologi klinik: studi tentang efek obat pada Farmakologi klinik: studi tentang efek obat pada manusia manusia farmakokinetik dan farmakodinamikfarmakokinetik dan farmakodinamikpidemiologi: studi mengenai distribusi dan pidemiologi: studi mengenai distribusi dan penyebab penyakit pada populasi tertentupenyebab penyakit pada populasi tertentu !adi" farmakoepidemiologi merupakan:!adi" farmakoepidemiologi merupakan:#lmu terapan yang men$embatani antara #lmu terapan yang men$embatani antara farmakologi klinik dan epidemiologifarmakologi klinik dan epidemiologi%enerapan metode epidemiologi pada ilmu %enerapan metode epidemiologi pada ilmu farmakologi klinikfarmakologi klinik #n epidemiology" primary focus is the relationship between e&posure to a risk factor and disease outcome'#n pharmacoepidemiology" the e&posure is the drug and the outcome is an ad(erse drug reaction')ence in many ways" pharmacoepidemiology is a subset of epidemiology and uses epidemiological methods *he study of the use *he study of the use and effects of and effects of medications in large medications in large numbers of peoplenumbers of people+trom+trom The application of epidemiologic knowledge, methods, and reasoning to the study of the effects (beneficial and adverse) and use of drugs in human populations.Porta and art!ema The study of drugs as determinants of health and disease in the general unselected population."pit!er Pharmacoepidemiology#linical pharmacology$pidemiology"trom PharmacoepidemiologyPharmacology$pidemiologyTherapeutics"tatistics"pit!er ealth servicesresearch#linical epidemiologyealth economics%utcomesresearchPharmaco&$pidemiology$pidemiology$conomics#onceptuali!ation by arry 'uess %harmacoepidemiology has four ma$or areas:, -enefit: obtained from efficacy and effecti(eness, +afety: obtained by pharmaco(igilance, .se: obtained by drug utili/ation re(iew, 0alue: obtained by pharmacoeconomics