Debate on aggressive vs restricted fluid resuscitation in childhood sepsis
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Transcript of Debate on aggressive vs restricted fluid resuscitation in childhood sepsis
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Give fluids!
Dr David Inwald
Consultant in PICU
St Mary’s Hospital and CATS
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Two pathophysiological reasons to give fluids in septic shock
• Fluid is in the wrong place
• The pump is not working
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Increased capillary permeability
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Sepsis
Warm shockHigh CO
vasodilation
Cold shockLow CO
vasoconstriction
Dysregulation of vascular tone
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Depression of myocardial contractility
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Shock
• A clinical syndrome of inadequate tissue perfusion
• DO2 < VO2
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Increasing DO2
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Therapeutic implications
GIVE FLUIDS
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Frank-Starling curve
fluids
inotropes
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How much fluid?
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Brierley J et al, Crit Care Med 2009; 37:666–688
Up to and over 60 ml/kg by
15 minutes
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Early reversal of shockEarly reversal of shockEvery hour without resuscitation and Every hour without resuscitation and
restoration of CRT < 2 s and normal BP restoration of CRT < 2 s and normal BP increases mortality by 40%!increases mortality by 40%!
Han YY et al Pediatrics. 2003;112:793-9
1 Hour 2 Hours 3 hours
10987654321
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Fluid resuscitation of hypovolemic shock: acute medicine's great triumph for
children
Carcillo JA and Tasker RC, ICM 2006;32:958-61
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Time (h)
Mor
talit
y
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FEAST management
• C - Circulation
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Developed world management
• A - Airway
• B - Breathing
• C - Circulation…
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Other therapies?• Haemofiltration• ECMO• Modulators of coagulation
• rh-APC• Protein C• Protein S• AT III• r-tPA
• Anti-endotoxin strategies• Polymixin• Anti-endotoxin antibodies (HA-1A)• rBPI21
• Prostacyclin
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Therapeutic implications
GIVE FLUIDS
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GIVE FLUIDS