De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain,...
Transcript of De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain,...
![Page 1: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/1.jpg)
NPA Annual Conference 2016
Kevin T. Bain, PharmD, MPH
Rachel Broudy, MD
De-Prescribing Medications in PACE:
Case-Based Approaches
NPA Annual Conference 2017
![Page 2: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/2.jpg)
Disclosures
• Kevin Bain: None to Report
• Rachel Broudy: None to Report
![Page 3: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/3.jpg)
Objectives
(1) Describe a theoretical framework for reducing polypharmacy in the
elderly
(2) Articulate a systematic approach for de-prescribing in PACE,
addressing polypharmacy
(3) Apply the principles and systematic approach to PACE participant case
scenarios
![Page 4: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/4.jpg)
Theoretical Framework and Systematic
De-Prescribing Approach in PACE
Kevin T. Bain, PharmD, MPH
![Page 5: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/5.jpg)
Definition of De-Prescribing
• The systematic process of identifying and discontinuing drugs in which existing
or potential harms/risks outweigh existing or potential benefits within the
context of an individual patient’s care goals, current level of functioning, life
expectancy, values, and preferences
• De-prescribing is not about denying effective treatment
It is a positive, patient-centered intervention…and requires the same good prescribing
principles that apply when drug therapy is started
Scott IA, et al. JAMA Intern Med. 2015;175(5):827-34.
![Page 6: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/6.jpg)
Reasons
WHEN TO CONSIDER DE-PRESCRIBING
![Page 7: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/7.jpg)
Pop Quiz!!!
• The most common reason for de-prescribing is actual increased risk
A. True
B. False
![Page 8: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/8.jpg)
Reasons to Consider De-prescribing
• Increased risk (actual) Patient is experiencing or has experienced a problem (e.g., side effect)
For example, new presentation of symptom, possibly representing an ADE
• Increased risk (potential) Patient is likely to experience a problem (e.g., adverse drug event)
For example, high risk medication (HRM) use in the elderly (e.g., fall)
• Lack of indication No clear, documented & current indication for medication use
For example, continued / long-term PPI use following initiation in the hospital
• Preventative benefit retained after stopping medication For example, continued osteoporosis prevention with bisphosphonate
Scott IA, et al. JAMA Intern Med. 2015;175(5):827-34.
![Page 9: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/9.jpg)
Reasons to Consider De-prescribing
• No or limited benefit Medication was never or only slightly effective in the first place, or
Time needed for medication benefit is shorter than patient life expectancy
For example, advanced disease / terminal illness
• Diminished benefit Medication is not as effective as it was initially, or
Medication treatment target no longer meets goal of care for patient
For example, anti-dementia medication >5-10 years of use / in progressive dementia
• Poor medication adherence Intended benefit not realized or potential harm
Scott IA, et al. JAMA Intern Med. 2015;175(5):827-34.
![Page 10: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/10.jpg)
![Page 11: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/11.jpg)
Reasons to Consider De-prescribingPolypharmacy
Atkin PA, et al. Drugs Aging. 1999;14(2):141-52.
http://health.gov/hai/ade.asp.
Doan J, et al. Ann Pharmacother. 2013;47(3):324-32.
The risk of an adverse drug event (ADE)
is 81% with ten or more medications.
OBVIOUS
82% of patients taking >8 drugs use at least one potentially
inappropriate medication (PIM).
The probability of >1 clinically-relevant DDI is 50% in geriatric
patients taking 5-9 medications, 81% with 10-14 medications, 92%
with 15-19 medications, and 100% with >20 medications.
![Page 12: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/12.jpg)
Reasons to Consider De-prescribingPolypharmacy
OBVIOUS
Medication storage
![Page 13: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/13.jpg)
Reasons to Consider De-prescribingPolypharmacy
OBVIOUS
Start U-500?
![Page 14: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/14.jpg)
Reasons to Consider De-prescribing
• What do we do when it is not so obvious?
• How do we determine when & which medications to de-prescribe?
The concept of Medication Utility
The term “medication utility” refers to whether a medication is useful in an individual clinical situation based on both the attributes of the
medication and those of its recipient
Let’s take a close look at some theoretical frameworks
![Page 15: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/15.jpg)
Theoretical Frameworks
HOW TO DETERMINE DE-PRESCRIBING
![Page 16: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/16.jpg)
Take a Deep Breath
![Page 17: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/17.jpg)
Medication Utility in GeriatricsWhy Should We Evaluate?
• Inappropriate medication use is prevalent
• Polypharmacy – use of multiple medications concomitantly
More medications added towards the end of life!
Risk of drug interactions & adverse drug events!
• Fragile health
• Short(er) life expectancy
• Goals of care – symptom management & QoL
![Page 18: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/18.jpg)
Framework 1
Homes HM, et al. Arch Intern Med. 2006;166(6):605-9.
less time palliative
curativemore time
![Page 19: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/19.jpg)
Medication Utility in GeriatricsHow Should We Evaluate?
Benefit-Risk Ratio
Population
Individualized Patient
Assessment
Benefit-Risk Ratio
Individual
![Page 20: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/20.jpg)
Medication Utility in GeriatricsBenefit-Risk Ratio – Population
• Benefits
Efficacy at population level
Number Needed to Treat (NNT)
• Risks
Safety data from trials & post-marketing surveillance
Number Needed to Harm (NNH)
![Page 21: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/21.jpg)
Medication Utility in GeriatricsIndividual Patient Assessment
• Will the patient benefit from the medication?
Does the patient’s remaining life expectancy exceed the medication’s
time until benefit being achieved?
• Is the medication a logical part of the patient’s treatment plan?
Compare the patient’s goals of care to the medication’s treatment target
Homes HM, et al. Arch Intern Med. 2006;166(6):605-9.
![Page 22: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/22.jpg)
Medication Utility in GeriatricsIndividual Patient Assessment
Remaining Life Expectancy
Holmes HM, et al. Arch Int Med. 2006;166(6):605-9..
Walter LC, et al. JAMA. 2001;285(21):2750-6.
Walter LC, et al. JAMA. 2001;285(23):2987-94.
![Page 23: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/23.jpg)
Medication Utility in GeriatricsIndividual Patient Assessment
Time Until Benefit
• Minutes/HoursAnalgesics
• MonthsBisphosphonates in osteoporosis
• YearsTight glycemic control in diabetes mellitus
• More difficult for othersStatins?
Holmes HM, et al. Arch Int Med. 2006;166(6):605-9.
Holmes HM, et al. Drugs Aging. 2013;30(9):655-66.
![Page 24: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/24.jpg)
Medication Utility in GeriatricsIndividual Patient Assessment
Goals of Care
• Prolong life
• Prevent morbidity
• Slow disease progression
• Prevent decline
• Comfort
Treatment Targets
• Primary prevention
• Secondary prevention
• Control chronic diseases
• Treat acute disease
• Medications for symptoms
Holmes HM, et al. Arch Int Med. 2006;166(6):605-9..
Sachs GA. J Amer Geriatr Soc. 1998;46(6):782-3.
![Page 25: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/25.jpg)
Medication Utility in GeriatricsIndividual Patient Assessment
more time
less time palliative
curative
Putting it all together
Homes HM, et al. Arch Intern Med. 2006;166(6):605-9.
![Page 26: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/26.jpg)
Medication Utility in GeriatricsBenefit-Risk Ratio – Individual
• Benefits Effectiveness in an individual patient
Cost
• Risks Adverse drug reactions (ADRs)
Adverse drug events (ADEs)
Drug interactions (drug-drug, drug-gene)
Comorbidities
Changing physical and/or functional status
![Page 27: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/27.jpg)
Hierarchy of Medication UtilityTheoretical Framework Applied to Hospice
less time palliative
more time curative
Low Utility
Questionable
Utility
High Utility
![Page 28: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/28.jpg)
Hierarchy of Medication UtilityTheoretical Framework Applied to Hospice
Nonessential Medications
of Palliative Care
Medications with Uncertain
Utility
Essential Medications of
Palliative Care
Amitriptyline
Bisacodyl
Dexamethasone
Gabapentin
Haloperidol
Senna
Dickerson D. Eur J Palliat Care. 1999;6(4):130-5.
De Lima L, et al. J Pain Palliat Care Pharmacother. 2007;21(3):29-36.
![Page 29: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/29.jpg)
Hierarchy of Medication UtilityTheoretical Framework Applied to Hospice
• FG is a 72-year-old man admitted to hospice for metastatic lung cancer
• Other past medical history Heart failure
Emphysema
Hypertension
Coronary artery disease
• Medications include the following: Furosemide
Lisinopril
Tiotropium
Simvastatin
Multivitamin
Case Scenario 1
![Page 30: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/30.jpg)
Hierarchy of Medication UtilityTheoretical Framework Applied to Hospice
Case Scenario 1
Essential
Uncertain
Nonessential
Benefit-Risk Ratio
Population
Individualized Patient
Assessment
Benefit-Risk Ratio
Individual
![Page 31: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/31.jpg)
Hierarchy of Medication UtilityTheoretical Framework Applied to Hospice
Case Scenario 1
furosemide
lisinopril
tiotropium
simvastatin
multivitamin
Benefit-Risk Ratio
Population
Individualized Patient
Assessment
Benefit-Risk Ratio
Individual
![Page 32: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/32.jpg)
Hierarchy of Medication UtilityTheoretical Framework Applied to Hospice
• BB is a 90-year-old male enrolled in hospice for end-stage Alzheimer’s disease (FAST 7-c)
• PMH includes chronic constipation, pressure ulcers and osteoarthritis
• BB is noted to be agitated and has lost 20 pounds over the past 3 months His caregiver (daughter) reports that he has experienced difficulty swallowing
and dry mouth over the same time period
Upon further inquiry, she indicates that her father started taking Tylenol® PM for sleep about 4 months ago after his wife passed away
• He ambulates with the assistance of a cane
Case Scenario 2
![Page 33: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/33.jpg)
Hierarchy of Medication UtilityTheoretical Framework Applied to Hospice
• His medications include the following:
Donepezil 10mg/day
Memantine 10mg/day
Celecoxib 200mg/day
Diphenhydramine-acetaminophen 25-500mg (Tylenol® PM) at bedtime
Folic acid 1mg/day
Vitamin C 500mg twice daily
Docusate 100mg twice daily
Case Scenario 2
![Page 34: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/34.jpg)
Hierarchy of Medication UtilityTheoretical Framework Applied to Hospice
• Which of B.B.’s medications should be considered for
discontinuation?
A. Folic acid
B. Vitamin C
C. Diphenhydramine-acetaminophen
D. All of the above
Case Scenario 2
![Page 35: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/35.jpg)
Framework 2
Scott IA, et al. JAMA Intern Med. 2015;175(5):827-34.
![Page 36: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/36.jpg)
Garfinkel D, et al. Isr Med Assoc J. 2007;9(6):430-4.
Framework 3
![Page 37: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/37.jpg)
Framework 3Good Palliative-Geriatric Practice Algorithm
• Among 70 community-dwelling older adults enrolled:
Baseline mean of 7.7 medications
Followed for a mean of 19 months
• Results:
91% of subjects eligible for de-prescribing of at least 1 medication
58% of all medications were eligible for de-prescribing (n=311)
81% of drugs were de-presribed successfully
88% of subjects reported global improvement in health
Garfinkel D, et al. Isr Med Assoc J. 2007;9(6):430-4.
![Page 38: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/38.jpg)
Bain KT, et al. J Am Geriatr Soc. 2008;56(10):1946-52.
Framework 4
![Page 39: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/39.jpg)
Systematic Approach
HOW TO DE-PRESCRIBE
![Page 40: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/40.jpg)
Beware
![Page 41: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/41.jpg)
Systematic De-Prescribing Approach
1. Recognize a Reason
2. Identify & Prioritize
3. Plan, Communicate, & Coordinate
4. Monitor
Abrupt or
Gradual Discontinuation
ADWEs and/or Improvement
(e.g., ADR or ADE)
![Page 42: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/42.jpg)
De-Prescribing Techniques
Gradual
Discontinuation
Abrupt
Discontinuation
Stop Slow as you Go Low !!
![Page 43: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/43.jpg)
Adverse Drug Withdrawal Events (ADWEs)
• Defined as any noxious, unintended, and undesired effect of
discontinuing a medication
• Clinical manifestations of an ADWE:
Physiological withdrawal
Exacerbation of underlying condition
New set of symptoms
Bain KT, et al. J Am Geriatr Soc. 2008;56(10):1946-52.
![Page 44: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/44.jpg)
Adverse Drug Withdrawal Events
• A study of 124 ambulatory elderly participants at the Durham VA
General Medicine Clinic who stopped taking medications
• ADWEs occurred in 30% of patients
88% exacerbation of underlying disease
Cardiovascular medications
CNS medications
1/3 resulted in urgent visit (e.g., urgent care, ED, hospitalization)
Median time to ADWE = 35 days
Range up to 4 months
No consistent deprescribing approach employed
Graves T, et al. Arch Intern Med. 1997;157(19):2205-10.
![Page 45: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/45.jpg)
Application to Patient Case Scenario
PRACTICAL DE-PRESCRIBING
![Page 46: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/46.jpg)
Systematic Approach ExampleHigh-Risk Medications (HRM)
1. Recognize anticholinergic burden
2. Avoid use or de-prescribe
3. Plan, Communicate, & Coordinate
4. Monitor
Abrupt or
Gradual Discontinuation
Cognitive function and/or ADWEs
Individual drug and cumulative
Highly Anticholinergic
Drugs
Change to alternative
or discontinue drug
![Page 47: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/47.jpg)
Systematic Approach ExampleStep 1: Recognize
• Pharmacist identifies drug(s) with high anticholinergic burden
Aided by computerized decision support
High anticholinergic burden is associated with cognitive & physical
dysfunction
Score 1 Score 2 Score 3
Alprazolam Carbamazepine Amitriptyline
Bupropion Cyproheptadine Oxybutynin
Ranitidine Meperidine Olanzapine / Quetiapine
Risperidone Oxcarbazepine Tolterodine
Anticholinergic Cognitive Burden Scoring of Drugs
![Page 48: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/48.jpg)
Systematic Approach ExampleStep 2: Prioritize
• Pharmacist makes recommendation to prescriber to change to
alternative drug or discontinue
What is the drug & indication?
Amitriptyline
– Depression: sertraline, citalopram, escitalopram, bupropion, duloxetine
– Neuropathic pain: duloxetine, gabapentin, pregabalin, capsaicin, lidocaine
– Insomnia: trazodone
Oxybutynin
– Incontinence: non-pharmacologic interventions (e.g., scheduled toileting)
![Page 49: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/49.jpg)
Systematic Approach ExampleStep 3: Plan, Communicate & Coordinate
• Pharmacist provides recommendation for de-prescribing
technique(s)
Amitriptyline 50mg at bedtime for insomnia
Reduce dose by 10-25mg every 5-7 days
Monitor symptoms +/- need for alternative drug
Oxybutynin 10mg twice daily for incontinence
Start scheduled toileting and diary
Reduce dose by 50% & evaluate for 72 hours
Discontinue drug after 72 hours, if feasible
Monitor success of non-pharmacologic intervention
![Page 50: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/50.jpg)
Systematic Approach Example Step 4: Monitor
• PACE physician discussed the negative anticholinergic effects of the drugs with
Mrs. Doe
• De-prescribing was initiated
• Follow-up visit 1 week later indicated successful management of UI & insomnia
Plan to complete discontinuation of oxybutynin & continue reduction of amitriptyline
• By 3 months later, Mrs. Doe’s MMSE score increased from 20 to 23
Her anticholinergic cognitive burden score was 2, which was a decrease from 8
![Page 51: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/51.jpg)
Application of De-Prescribing
to Real World Cases
Rachel Broudy, MD
![Page 52: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/52.jpg)
Disclosures
![Page 53: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/53.jpg)
Why don’t we de-prescribe?
www.dreamstime.com
![Page 54: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/54.jpg)
Why don’t we de-prescribe?
• Medical guidelines
• Not knowing why someone is on a medication or how long they have been on it
• Not wanting to change specialist recommendations
• Lack of clarity about life expectancy / goals of care
• Fears about withdrawal or recurrence of symptoms
• Time
• Participant preference
![Page 55: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/55.jpg)
Our Case
• A 75 year old male with CHF, DM, COPD and CAD, lives in
assisted living and is functional, able to complete most of his ADLs
with minimal assistance from staff at ALF. But has some mild
dementia, needs help with medications and personal care.
![Page 56: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/56.jpg)
Medical Guidelines
• DM
Metformin 500mg tid
• CAD
Simvastatin 80mg qhs
Aspirin 81mg qd
• COPD
Tiotropium 18mcg qd
Fluticasone propionate/
salmeterol 250/50 1 puff bid
• CHF
Furosemide 40mg bid
Spironolactone 25mg bid
Lisinopril 10mg qd
Metoprolol succinate 100mg qd
9 Medications (14 meds a day!)
before even moving on to
symptoms.
He also has insomnia, GERD and
osteoporosis.
![Page 57: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/57.jpg)
Unknown History
• This same 75 year old male with CHF, DM, COPD and CAD also has on his
med list:
omeprazole 40mg qam
calcium and vitamin D, 600mg/200IU bid
alendronate 70mg qweek
clopidogrel 75mg qd
gabapentin 300mg qhs
trazodone 50mg qhs
• Now we are at 15 medications, all of which seem somewhat reasonable
individually.
![Page 58: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/58.jpg)
15 Medications
Metformin 500mg tid
Simvastatin 80mg qhs
Aspirin 81mg qd
Tiotropium 18mcg qd
Fluticasone propionate/
salmeterol 250/50 1 puff bid
Furosemide 40mg bid
Spironolactone 25mg bid
Lisinopril 10mg qd
Metoprolol succinate100mg qd
Omeprazole 40mg qd
Ca/Vit D 600/200 bid
Alendronate70mg qwk
Clopidogrel 75mg qd
Gabapentin 300mg qhs
Trazodone 50mg qhs
Pharmacy Review
![Page 59: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/59.jpg)
Polypharmacy
![Page 60: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/60.jpg)
Specialist Recommendations
• My heart doctor put me on these medications and I’ve been fine
since then so I don’t want to go off them.
• They told me in the hospital I need these medications.
• My daughter says I should take a multivitamin every day
![Page 61: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/61.jpg)
Goals of Care and Physician Fears
• If these medications are helping me, I’ll keep taking them. I’m not
ready to die yet.
• What if I stop the statin and he has an MI?
• What if I stop the Fosamax and he falls and has a hip fracture?
• What if I stop the PPI and he has a GI bleed?
• What if I stop the spironolactone and he goes into heart failure?
![Page 62: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/62.jpg)
Time
• Every time he has a clinic visit, he has an acute issue, a cold,
insomnia, irritation with transportation, chest pain.
• There’s never time to do a complete medication review. Or a good
time to try down-titrating some of his chronic medications because
there’s always something acute and being a good geriatrician, you
don’t want to change too much at once.
![Page 63: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/63.jpg)
Participant Preference
![Page 64: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/64.jpg)
Is It Safe to De-prescribe?
• Garfinkel and Mangin published an article in the Archives of Internal Medicine
in 2010* and applied the Good Palliative-Geriatric Practice algorithm to 70
community dwelling older adults to recommend drug discontinuation.
• Mean age 82.8 years
• 61% had 3 or more comorbidities, 26% had 5 or more
• They recommended discontinuation of 58% of drugs (!), only 2% of which were
restarted
*Garfinkel D, Mangin D. Feasibility Study of a Systematic Approach for Discontinuation of Multiple Medications in Older
Adults. Arch Intern Med. 2010;170(18):1648-1655.
![Page 65: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/65.jpg)
Good Palliative-Geriatric Practice algorithm
(revised by Garfinkel)
![Page 66: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/66.jpg)
What did the study show?
![Page 67: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/67.jpg)
It works!
• “Discontinuation of a mean (range) 4.2 (1-11) different medications
in the cohort was safely achieved with no significant adverse events
or deaths related to discontinuation. Only 2% of drugs had to be
readministered; in 88% of elderly patients, application of the GP-GP
algorithm was associated with subjective clinical, functional, mood,
or cognitive improvement.”
![Page 68: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/68.jpg)
![Page 69: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/69.jpg)
So what do we do and how do we do it?
![Page 70: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/70.jpg)
Theoretical Framework 2
Scott IA, et al. JAMA Intern Med. 2015;175(5):827-34.
![Page 71: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/71.jpg)
Methods for Implementing De-prescribing
• Review need for medications in light of goals of care or when moving from one pathway to
another (longevity, functional, palliative)
• Use your pharmacist for participant medication reviews at transitions of care or in a more
targeted fashion
By medication (population-based, review all people on ppi’s)
By individuals (at transitions or other times)
Risk-based analysis (top 15% of patients with highest number of medications or highest
anticholinergic or sedative burden)
• Use your EHR
Goals in the care plan: reduce medications by 2 in next 6 months
Polypharmacy as a care plan problem (PCP, RN, ICHA)
![Page 72: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/72.jpg)
New admission to Mercy LIFE
• 84 year old female, living at home with stressed out family caregivers
• Diagnoses on admission:
dementia
hypertension
osteoporosis
chronic kidney disease
anemia
urinary incontinence
hyperlipidemia
![Page 73: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/73.jpg)
New Admission to Mercy LIFE
• On admission, medications are as follows: Donepezil 10mg qd
Lovastatin 40mg qhs
Magnesium oxide 400mg qd
Metoprolol tartrate 50mg bid
Quetiapine 25mg qam
Sertraline 12.5mg qam
Hydrochlorothiazide 12.5mg qd
Levetiracetam 500mg bid
Losartan 100mg qd
Omeprazole 20mg qd
![Page 74: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/74.jpg)
New Admission – Exam
• She is completely agitated, leaves the room swearing and shaking
her fist. Sentences complete, not disorganized, but not related to
current place, people, events
• Frail, cachectic
• 88 lbs (BMI 16.8)
• 97% RA, 96/60, 60, Afeb
• Exam deferred
![Page 75: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/75.jpg)
Method for De-prescribing: Goals of care
• It is clear that though she is new to the program, the goals around
her care should be more palliative in nature.
• She has end-stage dementia with behaviors threatening her safety
and safety of those around her.
• She has trouble swallowing pills and is cachetic.
• What can we get rid of? And in what order?
![Page 76: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/76.jpg)
Framework for De-prescribing
• No benefit
• Harm greater than benefit
• Treatment of non-existent (past, resolved, erroneous) symptoms or
diseases
• Preventive medications that won’t be beneficial over limited life
expectancy
![Page 77: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/77.jpg)
New Admission to Mercy LIFE
• On admission, medications are as follows: Donepezil 10mg qd
Lovastatin 40mg qhs
Magnesium oxide 400mg qd
Metoprolol tartrate 50mg bid
Quetiapine 25mg qam
Sertraline 12.5mg qam
Hydrochlorothiazide 12.5mg qd
Levetiracetam 500mg bid
Losartan 100mg qd
Omeprazole 20mg qd
![Page 78: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/78.jpg)
Review of her individual risk profile
• High anticholinergic burden: quetiapine
• High sedative burden: quetiapine, sertraline, levetiracetam
• Long QT syndrome: donepezil, quetiapine, hctz and sertraline
• Competing medications: lovastatin is high affinity for same receptor as
donepezil, weak affinity (CYP3A4) so higher levels of donepezil in blood
currently. Same for donepezil and metoprolol, high affinity for CYP2D6. So
even higher levels of donepezil on board.
Also, anticholinergic effects of quetiapine counteract cholinergic effects of
donepezil, which makes donepezil LESS effective
Sertraline levels increased by simultaneous use with quetiapine and ppi
(again, enzymes CYP3A4 and CYP2C19)
![Page 79: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/79.jpg)
Help!
![Page 80: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/80.jpg)
Plan
• Increase Seroquel over the weekend to two tabs bid or two bid with
one prn dose to see if that is effective for symptoms. If not, d/c that
and try something else.
• Stop: statin, magnesium, HCTZ and sertraline
![Page 81: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/81.jpg)
Plan Part 2
• Get medical history for seizures and clarify need for levetiracetam
• Trial off omeprazole when other issues stabilized
• Clarify if quetiapine works and if not, d/c
• Depending on goals of care and treatment of symptoms of agitation,
could try down-titration of donepezil as well
• That’s all her medications!
![Page 82: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/82.jpg)
Follow up
![Page 83: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/83.jpg)
64 year old female on 28 meds!
• 64 year old F with major recurrent depression and trauma history,
CAD, COPD (still smoking), DM, obesity, HTN and chronic pain.
• Her med list includes 28 meds!
• PRNs: albuterol nebs, Colace, icy hot patches so only 25
• (I don’t feel any better)
![Page 84: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/84.jpg)
64 year old female on 28 meds!
![Page 85: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/85.jpg)
Why 25 medications?
• DM with neuropathy: metformin, lantus, SSI, gabapentin
• CAD/HTN: clopidogrel (ASA intolerant), atenolol, isosorbide mononitrate,
lisinopril (off statin due to s/e currently)
• COPD: fluticasone/salmeterol, tiotropium, prn nebs and prn albuterol inhaler
• IBS: fiber, PPI, senna
• Chronic pain: oxycodone, tylenol
• UI: oxybutynin
• Major depression with trauma: fluoxetine, ziprasidone, clonazepam, trazodone
• Other: B12 IM qmonth, levothyroxine, flonase, vit D
![Page 86: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/86.jpg)
Methods for De-prescribing
• Targeted pharmacy review
• But again, can also ask for pharmacy reviews in a more
standardized way that is built into a QAPI plan such as:
Decrease the number of patients with dementia on anti-psychotics over the
next year
Decrease our use of PPI’s over the next year by 10%
Review top 10% of patient at high risk for medication adverse effects over
the next year (top 10% sedated, # of meds, anticholinergic burden, etc)
![Page 87: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/87.jpg)
Pharmacy Risk Profile
Strong anticholinergics
Oxybutynin
Strong sedatives
Clonazepam
Fluoxetine
Oxycodone
Gabapentin
Trazodone
Ziprasidone
Polypharmacy
Fairly obvious: 25 medications!
Long QT Syndrome drugs
Fluoxetine
Pantoprazole
Trazodone
Ziprasidone
![Page 88: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/88.jpg)
Example of a pharmacy review
![Page 89: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/89.jpg)
High risk meds – what can we d/c?
• Gabapentin – she refuses to d/c
• Atenolol – I think she needs BB due to her CAD and high cardiac risk
• Isosorbide mononitrate – it’s been the only thing that has worked for her HTN
• Lisinopril 40mg – I think she needs it for BP control and renal protection with DM
• Pantoprazole – she refuses to d/c, insists ranitidine doesn’t work
• Oxycodone – this is as good as it’s going to get
• Oxybutynin – she wants to continue this for QOL
• Fluoxetine – has been on it 20y, refuses trial off
• Ziprasidone – only medicine that has helped her since I’ve known her
• Trazodone – she still insists she sleeps poorly and wants more
• Clonazepam – not touchable at this point
![Page 90: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/90.jpg)
Now what?
• Motivational interviewing!
• Very gradual changes as we build trust and clinical improvement.
• Where should we focus?
![Page 91: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/91.jpg)
High risk meds – what can we change?
• Gabapentin – she refuses to d/c
• Atenolol – I think she needs BB due to her CAD and high cardiac risk
• Isosorbide mononitrate – I think she needs it for anginal sx
• Lisinopril 40mg – I think she needs it for BP control and renal protection
• Pantoprazole – she refuses to d/c, insists ranitidine doesn’t work
• Oxycodone – this is as good as it’s going to get
• Oxybutynin – she wants to continue this for QOL
• Fluoxetine – has been on it 20y, refuses trial off
• Ziprasidone – only medicine that has helped her since I’ve known her
• Trazodone – she still insists she sleeps poorly and wants more
• Clonazepam – not touchable at this point
![Page 92: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/92.jpg)
Motivational Interviewing
• Engage participants in a conversation in order to motivate change
• Address the area(s) where change is desired
• Elicit from the participant their own motivation for making the change
• Elicit a plan from the participant to make this change
• Based on autonomy, collaboration, evocation and exploration (v. authority,
confrontation, education and explanation)*
*Freedman, J; Combs, G. (1996). "Narrative Therapy: The Social Construction of Preferred Realities". New York: Norton.
![Page 93: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/93.jpg)
Motivational Interviewing
• You are on 4 medications for your mental health. Do you think you need all these
medications? Which ones do you think helped you? Which ones cause you side
effects?
• Clonazepam can cause or exacerbate depression. What if we just tried decreasing the
dose from 1mg tid to 0.5mg qam and continue the 2mg bid as before?
• Or, you have been on fluoxetine for a long time. Do you think it is helping you? It can
increase fatigue and the risk of cardiac arrhythmias. Maybe a decrease in dose would
make you feel better.
• Or, I know you have said you hate being on all of these medicines. Let’s review them
all and you chose one that you would like to decrease or stop and we can try that and
see how you feel. We can always re-start it if you don’t like how you feel off it.
![Page 94: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/94.jpg)
MI – patient focused decision making
• You are worried about your heart and having a heart attack. The
Clopidogrel is not working now with some of your other
medications. Are you willing to try going off the pantoprazole and
see how you feel?
• I know the oxybutynin helped your urinary symptoms at night. What
if we could get you that help with fewer side effects, like dry mouth
and light-headedness?
![Page 95: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/95.jpg)
Barriers?
• Time! She always has an acute issue. Is seen in clinic every week,
sometimes more.
• Solutions?
• Using the medical record to help trigger these reviews.
![Page 96: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/96.jpg)
Use of EHR to help with polypharmacy
• Add the problem to the reason for visit
![Page 97: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/97.jpg)
Use of EHR to help with polypharmacy
• Make polypharmacy it’s own medical problem
![Page 98: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/98.jpg)
Adding Polypharmacy to the Problem List
![Page 99: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/99.jpg)
Change in Condition or Transitions of Care
• 77 year old man joined program with dementia with behavior issues
and/or personality issues, DM, BPH, tremor, major depression with
anxiety.
• He is on a long list of medications and neither him or his son know
who started several of them and why he is on them.
![Page 100: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/100.jpg)
Initial Medication List
• B12 1000mcg qhs
• vit D3 2000 IU daily
• omeprazole 20mg qd
• colace 100mg bid
• senna 1 tab qhs
• miralax daily
• memantine10mg qd
• finasteride 5mg
• tamsulosin 0.4mg qhs
• oxybutynin ER 5mg daily
• pravastatin 20mg
• glipizide 2.5mg bid
• paroxetine 40mg
• lamotrigine 200mg daily at
• primidone 150mg qam and 100mg
qpm
• mestinon 60mg tid
• trazodone 25mg bid prn
• buproprion XL 300mg daily am
![Page 101: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/101.jpg)
Change in Condition
• Soon after enrollment he develops new onset ascites and
pulmonary edema due to undiagnosed cirrhosis. He is admitted to
the hospital for treatment. He is diuresed and medications are
added for his ascites.
• So PCP asks pharmacy for a review of medications in light of his
liver disease.
![Page 102: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/102.jpg)
Harm or benefit?
![Page 103: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/103.jpg)
Medication Review
• Memantine – taper off, not at full dose, not clear there is benefit
• Mestinon – for tremors, harm>benefit, taper off
• Tamsulosin with many s/e and drug interactions but urinary frequency is his
biggest complaint so kept it for QOL
• Buproprion decreased to 75mg qd due to hepatic dosing
• Tapered down paroxetine and lamotrigine
• Trazodone was a prn, stopped this
![Page 104: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/104.jpg)
Implementation of De-prescribing
• Entry of polypharmacy into LIFEplan with plan noted there with
pharmacist recommendations
• Repeating monthly clinic visit x 6 for polypharmacy
• Family meeting to review prognosis, goals of care
![Page 105: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/105.jpg)
Family Meeting
• Reviewing goals of care and
life expectancy with participant
and family, we elicited goals for
function, quality of life, and not
too many meds, and made
adjustments based on that.
![Page 106: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/106.jpg)
Theoretical Framework 2
Scott IA, et al. JAMA Intern Med. 2015;175(5):827-34.
![Page 107: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/107.jpg)
QAPI
![Page 108: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/108.jpg)
Using QAPI to help with polypharmacy
• Ask your pharmacists for a list of everyone on a medication or
medication class that you would like to review for appropriateness.
PPIs
Anti-psychotics
Statins
Or all those on 10 or more medications
• Arrange monthly medication review for those participants in clinic to
follow up on the indications for these medications
![Page 109: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/109.jpg)
Last Minute Tips
• Medications to think about:
PPIs – risks for adverse reactions and events (e.g., C. diff diarrhea, falls)
Anticholinergic & sedative burden – risks for cognitive & physical
dysfunction
Polypharmacy – risks for falls and poor outcomes
Beers Criteria drugs – risks for poor outcomes
Bisphosphonates – use only 5y, benefit begins after 1.5y of tx, risk of
atypical fx increases after 2-5y of therapy
![Page 110: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/110.jpg)
Last Minute Tips 2
• Conditions to think about:
Statins for primary prevention – LE should be at least 2y to gain benefit
(length of studies)
DM – 10 years to develop proteinuria. Do you need the ACEI?
Aspirin – needed 5 years to decrease risk of MI in pts with DM
![Page 111: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/111.jpg)
So what do we do and how do we do it?
• Safety: drug interactions, high risk medications
• Goals of care and participant preference
• Life expectancy and review of preventive medications
• Transitions of care
• QAPI
![Page 112: De-Prescribing Medications in PACE: Case-Based …...NPA Annual Conference 2016 Kevin T. Bain, PharmD, MPH Rachel Broudy, MD De-Prescribing Medications in PACE: Case-Based Approaches](https://reader034.fdocuments.net/reader034/viewer/2022050403/5f80755a8ce45900fc4bd042/html5/thumbnails/112.jpg)
Audience Discussion
• Your experiences?
• Challenges?
• Successes?
• Standardized care plan interventions?
• Tools or strategies to increase participant buy-in?