Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 [email protected] ...
-
Upload
hugh-strickland -
Category
Documents
-
view
219 -
download
2
Transcript of Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 [email protected] ...
![Page 1: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/1.jpg)
Data Processing & Analysis of Resting-State fMRI
Chao-Gan YAN, Ph.D.严超赣
[email protected]://rfmri.org
Research Scientist The Nathan Kline Institute for Psychiatric Research
Research Assistant Professor Department of Child and Adolescent Psychiatry /
NYU Langone Medical Center Child Study Center, New York University
![Page 2: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/2.jpg)
Outline• Overview
• Data Preparation
• Preprocessing
• R-fMRI measures Calculation
• Quality Control
• Statistical Analysis
• Results Viewing2
![Page 3: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/3.jpg)
DPARSF
(Yan and Zang, 2010) 3
![Page 4: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/4.jpg)
Data Processing Assistant for Resting-
State fMRI (DPARSF)
Yan and Zang, 2010. Front Syst Neurosci.
4
http://rfmri.org/DPARSF
![Page 5: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/5.jpg)
DPABI: a toolbox for Data Processing & Analysis of Brain
Imaging
5
http://rfmri.org/dpabi
http://dpabi.org
License: GNU GPL
Chao-Gan Yan Programmer
Initiator
Xin-Di Wang Programmer
![Page 6: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/6.jpg)
Outline• Overview
• Data Preparation
• Preprocessing
• R-fMRI measures Calculation
• Quality Control
• Statistical Analysis
• Results Viewing6
![Page 7: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/7.jpg)
Data Organization
ProcessingDemoData.zip
FunRawSub_001
Sub_002
Sub_003
T1RawSub_001
Sub_002
Sub_003
Functional DICOM data
Structural DICOM data
http://rfmri.org/DemoData7
![Page 8: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/8.jpg)
Data Organization
ProcessingDemoData.zip
FunImgSub_001
Sub_002
Sub_003
T1ImgSub_001
Sub_002
Sub_003
Functional NIfTI data (.nii.gz., .nii or .img)
Structural NIfTI data (.nii.gz., .nii or .img)
8
![Page 9: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/9.jpg)
9
![Page 10: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/10.jpg)
10
![Page 11: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/11.jpg)
Outline• Overview
• Data Preparation
• Preprocessing
• R-fMRI measures Calculation
• Quality Control
• Statistical Analysis
• Results Viewing11
![Page 12: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/12.jpg)
12
![Page 13: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/13.jpg)
Preprocessing
Working Dir where stored Starting Directory (e.g.,
FunRaw)Detected participants
13
![Page 14: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/14.jpg)
Detected participants
14
Preprocessing
![Page 15: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/15.jpg)
Number of time points(if 0, detect
automatically)TR(if 0, detect from
NIfTI header)
Template Parameters
15
Preprocessing
![Page 16: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/16.jpg)
Resting State fMRI Data Processing
Template Parameters
16
![Page 17: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/17.jpg)
17
What’s new?
![Page 18: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/18.jpg)
Reorient and Quality control
18
![Page 19: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/19.jpg)
19
![Page 20: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/20.jpg)
Automask generation
20
For checking EPI coverage and generating group mask
FunImgAR/Sub_001
Masks/AutoMasks/
![Page 21: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/21.jpg)
Brain extraction(Skullstrip)
For Linux and Mac: Need to install FSL.
For Windows:Thanks to Chris Rorden's compiled version of bet in MRIcroN, our modified version can work on NIfTI images directly.
21
For better coregistration
![Page 22: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/22.jpg)
22
T1Img/Sub_001
T1ImgBet/Sub_001
RealignParameter/Sub_001/mean*.nii
RealignParameter/Sub_001/Bet_mean*.nii
bet
Coregister
Apply
T1ImgCoreg/Sub_001
Segment
Bet & Coregistration
![Page 23: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/23.jpg)
Nuisance regression
23
![Page 24: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/24.jpg)
Nuisance Regression
24
Mask based on segmentation or SPM apriori CompCor or mean [note: for CompCor, detrend (demean) and variance
normalization will be applied before PCA, according to Behzadi et al., 2007] Global Signal based on Automask
![Page 25: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/25.jpg)
Outline• Overview
• Data Preparation
• Preprocessing
• R-fMRI measures Calculation
• Quality Control
• Statistical Analysis
• Results Viewing25
![Page 26: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/26.jpg)
26
R-fMRI measures
Calculation
![Page 27: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/27.jpg)
Outline• Overview
• Data Preparation
• Preprocessing
• R-fMRI measures Calculation
• Quality Control
• Statistical Analysis
• Results Viewing27
![Page 28: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/28.jpg)
28
![Page 29: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/29.jpg)
29
Quality Control
![Page 30: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/30.jpg)
30
Quality Control
![Page 31: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/31.jpg)
31
Quality Control
![Page 32: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/32.jpg)
32
Quality Control
![Page 33: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/33.jpg)
33
Quality Control
![Page 34: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/34.jpg)
34
Quality Control
![Page 35: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/35.jpg)
35
Quality Control
![Page 36: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/36.jpg)
36
Quality Control
![Page 37: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/37.jpg)
37
Quality Control
![Page 38: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/38.jpg)
38
Quality Control
![Page 39: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/39.jpg)
39
Quality Control
![Page 40: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/40.jpg)
40
Quality Control
![Page 41: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/41.jpg)
41
Quality Control
This mask is very important for group statistical analysis!!!
![Page 42: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/42.jpg)
42
Quality Control
![Page 43: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/43.jpg)
43
Quality Control
![Page 44: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/44.jpg)
44
Quality Control
![Page 45: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/45.jpg)
45
Quality Control
Yan et al., 2013, Neuroimage
Using the visual inspection step within DPARSF, subjects showing severe head motion in the T1 image and subjects showing extremely poor coverage in the functional images, as well as subjects showing bad registration were excluded
Subjects with overlap with the group mask (voxels present at least 90% of the participants) less than 2*SD under the group mean overlap (threshold: 92.2%) were excluded
Subjects with motion (Mean FD Jenkinson greater than 2*SD above the group mean motion (threshold: 0.192) were excluded
![Page 46: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/46.jpg)
Outline• Overview
• Data Preparation
• Preprocessing
• R-fMRI measures Calculation
• Quality Control
• Statistical Analysis
• Results Viewing46
![Page 47: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/47.jpg)
47
![Page 48: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/48.jpg)
48
Statistical Analysis
![Page 49: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/49.jpg)
49
Statistical Analysis
{DPABI_Dir}/StatisticalAnalysis/y_GroupAnalysis_Image.m
![Page 50: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/50.jpg)
50
Attention!!!
![Page 51: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/51.jpg)
51
Statistical Analysis
{DPABI_Dir}/StatisticalAnalysis/y_GroupAnalysis_Image.m
Smoothness estimation based on the 4D residual is built in this function!!!
![Page 52: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/52.jpg)
52
Statistical Analysishttp://rfmri.org/DemoData
{Download}/ProcessingDemoData/StatisticalDemo/AD_MCI_NC/
ALFF: AD – NC Two Sample T Test:
• Applied smooth kernel in preprocessing: [4 4 4]
• Smooth kernel estimated on 4D residual: [6.77 6.88 6.71]
• Smooth kernel estimated on statistical image (T to Z, as in easythresh): [6.90 7.33 6.94]
ReHo: AD – NC Two Sample T Test:
• Applied smooth kernel in preprocessing: [4 4 4]
• Smooth kernel estimated on 4D residual: [8.10 8.50 7.93]
• Smooth kernel estimated on statistical image (T to Z, as in easythresh): [8.33 8.94 8.24]
Thus, only using smooth kernel applied in preprocessing is NOT sufficient!!!
![Page 53: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/53.jpg)
Outline• Overview
• Data Preparation
• Preprocessing
• R-fMRI measures Calculation
• Quality Control
• Statistical Analysis
• Results Viewing53
![Page 54: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/54.jpg)
54
![Page 55: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/55.jpg)
55
![Page 56: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/56.jpg)
5656
![Page 57: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/57.jpg)
57
![Page 58: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/58.jpg)
5858
![Page 59: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/59.jpg)
59
![Page 60: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/60.jpg)
6060
![Page 61: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/61.jpg)
61
Voxel Z > 2.3, Cluster P < 0.05, Two One-Tailed Corrections:
equivalent to
Voxel P < 0.0214, Cluster P < 0.1, Two Tailed.
![Page 62: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/62.jpg)
62
![Page 63: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/63.jpg)
63
![Page 64: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/64.jpg)
6464
![Page 65: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/65.jpg)
6565
![Page 66: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/66.jpg)
6666
![Page 67: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/67.jpg)
6767
![Page 68: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/68.jpg)
6868
Further Help
Further questions:
http://rfmri.org/dpabi
http://dpabi.orgThe R-fMRI Network
![Page 69: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/69.jpg)
6969
Further Help
![Page 70: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/70.jpg)
7070
![Page 71: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/71.jpg)
7171
![Page 72: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/72.jpg)
7272
Send emails only to [email protected]: 1) sending new email means you are posting your personal blogs, 2) replying email means you are posting comments to that topic/blog, 3) then all the other R-fMRI nodes will receive email updates of your posts.
![Page 73: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/73.jpg)
Xin-Di Wang Programmer
Yu-Feng Zang Consultant
![Page 74: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/74.jpg)
Acknowledgments
Nathan Kline Institute
Charles Schroeder
Stan Colcombe
Gary Linn
Mark Klinger
Child Mind Institute
Michael P. Milham
R. Cameron Craddock
Zhen Yang
NYU Child Study Center
F. Xavier Castellanos
Adriana Di Martino
Clare Kelly Chinese Academy of Sciences
Xi-Nian Zuo
Hangzhou Normal University
Yu-Feng Zang
Princeton University
Han Liu
Fudan University
Tian-Ming Qiu
Beijing Normal University
Yong He
![Page 75: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/75.jpg)
75
Advertisement
F. Xavier CastellanosNKI/NYU
Charles E. SchroederNKI/Columbia
David A. LeopoldNIMH
![Page 76: Data Processing & Analysis of Resting-State fMRI Chao-Gan YAN, Ph.D. 严超赣 ycg.yan@gmail.com Research Scientist The Nathan Kline Institute.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e0b5503460f94af2843/html5/thumbnails/76.jpg)
76
Thanks for your attention!