CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology...
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Transcript of CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology...
![Page 1: CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology Assaf Harofeh Medical Center Israel The authors have no.](https://reader036.fdocuments.net/reader036/viewer/2022062421/56649f535503460f94c77801/html5/thumbnails/1.jpg)
CXL for
Infectious Keratitis
David Zadok, Yaakov Goldich, Isaac Avni
Department of Ophthalmology Assaf Harofeh Medical Center
Israel
The authors have no conflicts of interest and no financial interest in the article’s subject matter or methods mentioned.
![Page 2: CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology Assaf Harofeh Medical Center Israel The authors have no.](https://reader036.fdocuments.net/reader036/viewer/2022062421/56649f535503460f94c77801/html5/thumbnails/2.jpg)
The combined application of riboflavin and UV inactivates pathogens
– UV light alone has been shown to cause changes in
the nucleic acids of pathogens so they cannot replicate (oxygen radicals).
– Exposure to UV light activates the riboflavin in the complex and causes a chemical alteration to functional groups of the nucleic acids (primarily guanine bases), making pathogens unable to replicate
![Page 3: CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology Assaf Harofeh Medical Center Israel The authors have no.](https://reader036.fdocuments.net/reader036/viewer/2022062421/56649f535503460f94c77801/html5/thumbnails/3.jpg)
Case 1
• 21-year-old female
• Soft, color contact lenses,
otherwise healthy
• RE: few weeks painful red eye,
decreased vision, photophobia,
treated with dexamethasone and
chloramphenicol
• Signs: bulbar injection,
nonsuppurative ring infiltrate,
perineuritis
![Page 4: CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology Assaf Harofeh Medical Center Israel The authors have no.](https://reader036.fdocuments.net/reader036/viewer/2022062421/56649f535503460f94c77801/html5/thumbnails/4.jpg)
• Clinical presentation: m/p Acanthamoeba keratitis
• Samples were taken from the conjunctiva, cornea, and contact lens containers and fluids – negative
• Rx: PHMB,(Chlorhexidine), Brolene
• CXL – TCL, ofloxacin, dexamethasone
Case 1
![Page 5: CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology Assaf Harofeh Medical Center Israel The authors have no.](https://reader036.fdocuments.net/reader036/viewer/2022062421/56649f535503460f94c77801/html5/thumbnails/5.jpg)
Case 1
• Within a few days after the CXL treatment, the pain decreased, gradual reepithelization
• Two months after the treatment, the cornea was completely healed and the patient had no pain
![Page 6: CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology Assaf Harofeh Medical Center Israel The authors have no.](https://reader036.fdocuments.net/reader036/viewer/2022062421/56649f535503460f94c77801/html5/thumbnails/6.jpg)
Case 2
• 66-year-old female
• BE s/p PKP +Phaco+PC IOL (RE-2009 LE-2006)
• Dx: LE corneal abscess
• Laboratory workup – negative
• Rx: cefamezine + garamycin – worst
vancomycin + ceftazidime - worst
• CXL- TCL, dexamethasone, chloramphenicol
• Within a few days after the CXL treatment the abscess
healed
![Page 7: CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology Assaf Harofeh Medical Center Israel The authors have no.](https://reader036.fdocuments.net/reader036/viewer/2022062421/56649f535503460f94c77801/html5/thumbnails/7.jpg)
Case 3
• 42-year-old male
• BE s/p PKP (Keratoconus)(RE-2009, LE-2007), RGP CL
• Dx: LE corneal abscess
• Eye culture- Serratia marcescens
• Rx: moxifloxacin – worst, cefamezine + garamycin - worst, vancomycin + ceftazidime - worst
![Page 8: CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology Assaf Harofeh Medical Center Israel The authors have no.](https://reader036.fdocuments.net/reader036/viewer/2022062421/56649f535503460f94c77801/html5/thumbnails/8.jpg)
Case 3
• CXL – TCL, dexamethasone, garamycin, cefamezine
• Corneal melting – doxycyline
• LE PKP – replacing melted corneal button
![Page 9: CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology Assaf Harofeh Medical Center Israel The authors have no.](https://reader036.fdocuments.net/reader036/viewer/2022062421/56649f535503460f94c77801/html5/thumbnails/9.jpg)
Case 3
![Page 10: CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology Assaf Harofeh Medical Center Israel The authors have no.](https://reader036.fdocuments.net/reader036/viewer/2022062421/56649f535503460f94c77801/html5/thumbnails/10.jpg)
Summery
• UVA-riboflavin crosslinking can be useful for the treatment of corneal abscesses unresponsive to medical treatment
![Page 11: CXL for Infectious Keratitis David Zadok, Yaakov Goldich, Isaac Avni Department of Ophthalmology Assaf Harofeh Medical Center Israel The authors have no.](https://reader036.fdocuments.net/reader036/viewer/2022062421/56649f535503460f94c77801/html5/thumbnails/11.jpg)
Thank You