CVI Clinical Trial Research Manager In an Era of Big...
Transcript of CVI Clinical Trial Research Manager In an Era of Big...
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Clinical Biomarker Discovery Training Program Modern Technologies and Applications in Biomarker Discovery
CVI is organizing a training program for post-doctoral researchers and clinicians that will cover how to utilize modern tools and tech-nologies in biomarker discovery from cell and fluid based assays.
Dr. Holden Maecker Multiplexing Biomarker Discovery, Nanoimmunoassay
Dr. Gary Nolan Mass Cytometry
Dr. Shan Wang GMR Nanosensors in Biomarker Discovery
Dr. Jayakumar Rajadas, Founding Director, Biomaterials and Advanced Drug Delivery Laboratory LC-MS-Based Method for Quantification of Biomarkers from Bio Fluids
CVI QUARTERLY | FALL 2014Pioneering Innovative Research for Cardiovascular Medicine
Sanjiv Narayan, MD
Robert A. Harrington, MD
Doff McElhinney, MD
Ashima Goel
Jayakumar Rajadas, PhD
Dr. Narayan is embarking on a new venture and joining the Stanford team as Professor of Med-icine and Director Electrophysiology Research and Atrial Fibrillation Program. He is trained in software engineering, cardiology and heart rhythm medicine. His clinical care research has led to unique ablation therapies for atrial fibrillation (AF) and ventricular arrhythmias.
Dr. McElhinney, a pediatric/congenital inter-ventional cardiologist, recently returned to the Bay Area to assume his current role of Professor of Cardiothoracic Surgery and Di-rector of Clinical Outcomes and Translational Research in the Lucille Packard Children’s Hospital Heart Center. His interests are in out-comes research, transcatheter device therapy
for congenital heart disease, and collaborative translational investigation related to the pathophysiology, evaluation, and management of pediatric and adult congenital heart disease. He is currently an Associate Editor of the journal Circulation: Cardiovascular Interventions, and is the Chair of the Congenital Heart Disease Council of the Society for Cardiovascular Angiog-raphy and Interventions.
New Faculty
In a recent article, Dr. Harrington discusses the era of “big data” in cardiovascular medicine. ‘This brings both excitement and
challenges to the clinician who is making doz-ens, if not hundreds, of clinical decisions every day in the care of individual patients.’ Calcu-lating risks and benefits to help guide revas-cularization decisions: turning all available data into useful information was published in the Journal of the American College of Cardiology (J Am Coll Cardiol. 2014 Aug 5).
CLINICAL HIGHLIGHTS
FEATURED STORY
In an Era of Big Data
Digoxin Tied to Increased Risk of Death with Atrial Fibrillation Becky Bach, Stanford Medicine Office of Communication & Public Affairs
Woolly foxglove Mintu Turakhia, MD
CVI Clinical Trial Research ManagerAshima Goel has joined CVI as clinical tri-al research manager starting September 1, 2014. She comes to us from Pediatrics - Infec-tious Disease department at Stanford School of
Medicine where she was working as a clinical research coordi-nator managing vaccine related NIH sponsored studies. Prior to that she worked at the Stanford IRB as an IRB associate. She ob-tained her MS in Molecular Biology from San Jose State Univer-sity. She has over 10 years of industry and academic experience.
Dr. Mintu Turakhia has a new study showing that patients with a heart condition known as atrial fibrillation (AF) have a higher risk of death from the drug digoxin. Dr. Turakhia is now extend-ing the AF outcomes research work into the Big Data analysis using machine learning. Story continued on page 4
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Preventing Sudden Cardiac Death: Embracing the Gootter Mission
Each day in the United States, about 1,000 lives are lost to sudden cardiac death (SCD). The Stanford Cardiovascular Institute is embracing the Gootter Foundation mission and with generous support initiating projects aimed at preventing SCD.
The Gootter Foundation was established in memory of Steven M. Gootter to raise awareness and support for SCD research. In an unparalleled move to prevent avoid-able deaths from sudden cardiac arrest, the Steven M. Gootter Foundation has provided Automated External Defibrilla-tors (AEDs) to over 40 Southern Arizona
schools, places of worship and recreational centers that did not have these life saving devices.
Dr. Curt Scharfe and Dr. Kitch Wilson are developing a molecular diagnostic test that will identify genetic mutations associated with SCD. The goal is to create cost-effective tools for cardiologist here at Stanford and beyond to assess patients at risk for SCD.
A seed grant award from the Gootter Foundation will also support Dr. Marco Perez, Director of the Stanford Inherited Cardiac Arrhythmia Clinic. Hypertrophic cardiomy-opathy (HCM), in which a portion of the myocardium is thickened, is the most common cause of sudden death in athletes in the United States. Dr. Perez is working on im-proving the diagnostic accuracy for HCM and standardizing preventative measures for athletes. By comparing electrocardiogram (ECG) readings of 450 HCM patients treated at Stanford against 1,200 Stanford athletes, Dr. Perez will identify the ECG criteria that best distinguish normal athletes from athletes at risk for HCM and sudden death.
Visit the Gootter Foundation at website: www.stevenmgootterfoundation.org
About the Stanford Cardiovascular Institute (CVI)CVI, currently consists of 110 faculty mem-bers representing, engineers, physicians, surgeons, basic and clinical researchers. At the core of CVI is integrating fundamental research across disciplines and applying technology to prevent and treat cardiovas-cular disease. To support cardiovascular research and education at CVI please con-tact Cathy Hutton, Senior Associate Direc-tor, Medical Center Development ([email protected]) or Dr. Ingrid Ibarra ([email protected]).
Curt Scharfe, PhD Marco Perez, MD Kitch Wilson, MD, PhD
Cathy Hutton, Senior Associate Director, Medical Center Devel-opment
A New Platform for Screening Therapies Against Viral Myocarditis
Viral myocarditis, charac-terized by inflammation in the heart muscle, of-ten leads to heart failure, cardiac arrhythmias or sudden death. In many cases, a single-stranded RNA enterovirus, coxsacki-evirus B3 virus (CVB3), is the pathological agent. In a fruitful collaboration between the laboratories of Drs. Joseph C. Wu and Sean M. Wu and co-men-tored medical student,
Arun Sharma, showed that human induced pluripotent stem cell-derived cardiomyocytes are receptive to CVB3 infection. The CVB3 re-porter assay, which was featured in Circula-tion Research, uses bioluminescence imaging to monitor viral infection and replication. Other CVI Stanford co-authors include Jan E. Carette, PhD, Assistant Professor of Microbiol-ogy and Immunology and Kristy Red-Horse, PhD, Assistant Professor of Biology.
In addition, recent research in Dr. Joseph Wu’s lab on genome editing (Wang et al.) of iPSC-heart cells for drug screening and on epigenetic memory (Sanchez-Freire et al.) of iPSC-heart cells was published as back-to-back papers in the Journal of American College of Cardiology, with 3 ac-companied editorials.
Dr. Sean Wu recently published work showing that Insulin-like growth factor promotes car-diac lineage induction. Stem Cells. 2014 Jun.
Ingrid Ibarra, PhD Assistant Direc-tor of Stanford Cardiovascular Institute
Arun Sharma
Sean Wu, MD, PhD
Volume 115, Number 6, August 29, 2014ISSN 0009-7330http://circres.ahajournals.org
AmericanHeartAssociation®
CirculationResearch
Human iPSC-CMs as a Model for Viral Myocarditis p 556
Mutations in STAP1 Associate With ADH p 552
TRPC Channels and Post-MI Remodeling p 567
Gain-of-Function LDLR for Treating FH p 591
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Physicians Deactivate Heart Pump with Catheter-Based Approach By Sara Wykes, Stanford Hospital & Clinics communications office
A mechanical pump supported a failing heart, but did the job so well it eventually was no longer needed. Turning it off safely was the challenge. Donna Jackson spent nearly three years with an implanted device to boost her heart, but recovered well enough that she no longer needed it.
Donna Jackson’s heart, on the verge of failing two years earlier, had made a strong recovery. By spring 2013, she no longer needed the left ventricular assist device, or LVAD, that had been implanted in her chest almost three years earlier. It got in the way of things she wanted to do, like swim with her grandchildren. But her doc-tors at Stanford Hospital & Clinics believed the 70-year-old resident of the Central Valley would have trouble surviving the surgery to remove the mechanical heart pump. So they decided to find another way.
Jackson’s doctors threaded a slim plastic tube through a small incision to her femoral artery in the groin and up to her aorta, allowed them to plug the flow of blood to the LVAD. Then, they cut, cleaned and capped the wiring powering the LVAD so it no longer emerged from an opening in her abdomen. (The LVAD remains inside Jackson’s chest.) Jackson returned home from Stanford Hospital five days after the procedure. Their solution - is described in a paper published in the August issue of the Annals of Thoracic Surgery.
She has inspired the Stanford team to begin research on how to predict which LVAD patients might be like her. “If we can find out which patients are going to recover sooner, we can be more aggressive with them so they can be liberated from the LVAD,” said co-author Dipanjan Banerjee, MD, clinical assistant professor of cardiovascular medicine and medical director of Mechanical Circulatory Support Program. “And many of these patients will not want nor be able to tolerate a complete removal of the LVAD.”
The LVAD’s history of clinical performance and evolving technology puts it in a special category of devices whose usefulness continues to develop over time. The U.S. Food and Drug Administration in 1984 approved it as a “bridge” for patients on a path toward needing a heart transplant. Physicians eventually realized that some of their patients did so well with LVAD support that they no longer needed a transplant, and the FDA approved the device for permanent use in 2010. But an estimated 1 to 2 percent of LVAD patients’ hearts recover enough to do fine without that mechanical support. Younger patients are able to tolerate the major surgery required to remove the LVAD completely, but the surgery poses major risks for older patients.
To plan the new procedure, Ha and Banerjee consulted with two of the paper’s other authors: Philip Oyer, MD, PhD, associate chair of cardiothoracic surgery, and the first person to successfully use the LVAD as a bridge to transplant; and interventional radiologist Michael Dake, MD, professor of cardiothoracic surgery and medical director of Stanford’s Catheterization and Angiography Laboratories.
Other Stanford authors are Ahmad Sheikh, MD, clinical assistant professor of cardiothoracic surgery at Stanford; Peter H.U. Lee, MD, a former clinical instructor; and former resident Jay Desai, MD.
Information about the Department of Cardiothoracic Surgery, which helped to support the work, is avail-able at http://ctsurgery.stanford.edu.
https://med.stanford.edu/news/all-news/2014/07/physicians-deactivate-heart-pump-with-catheter-based-approach.html
Dipanjan Banerjee, MD
Philip Oyer, MD, PhD
Michael Dake, MD
Richard Ha, MD
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An inexpensive, portable, microchip-based test for diagnosing type-1 diabetes could improve patient care worldwide and help researchers better understand the disease, according to the de-vice’s inventors at the Stanford University School of Medicine.
Described in a paper published online July 13 in Nature Medi-cine, the test employs nanotechnology to detect type-1 diabetes outside hospital settings. The handheld microchips distinguish between the two main forms of diabetes mellitus, which are both characterized by high blood-sugar levels but have differ-ent causes and treatments. Until now, making the distinction has required a slow, expensive test available only in sophisticated health-care settings. The researchers are seeking Food and Drug Administration approval of the device.
“With the new test, not only do we anticipate being able to di-agnose diabetes more efficiently and more broadly, we will also understand diabetes better — both the natural history and how new therapies impact the body,” said Brian Feldman, MD, PhD, assistant professor of pediatric endocrinology and the Bechtel Endowed Faculty Scholar in Pediatric Translational Medicine. Feldman, the senior author of the paper, is also a pediatric endo-crinologist at Lucile Packard Children’s Hospital Stanford.
In An Account of the Foxglove And Some of its Medical Uses, published in 1785, Sir William Withering cautioned readers that foxglove was not a perfect drug. “Time will fix the real value upon this discovery,” he wrote.
Foxglove, a genus of flowering plants, contains cardiac glycosides, which can be used to treat heart failure and atrial fibrillation — a rapid and irregular heart rhythm. Now, more than 200 years later, re-searchers at the School of Medicine have validated Withering’s warning with the discovery that patients with atrial fibrillation who are treated with digoxin, a glycoside commonly extracted from woolly fox-glove, are more likely to die than similar patients who received different treatments.
“The take-home point is to question whether people should really be on this drug,” said the study’s lead au-thor, Mintu Turakhia, MD, assistant professor of cardiology at Stanford and director of cardiac electrophysi-ology at the Veterans Affairs Palo Alto Health Care System. “These data challenge the current guidelines.”
Turakhia and his team analyzed records from 122,465 patients who received a new diagnosis of atrial fibrillation from the U.S. Department of Veterans Affairs health-care system between 2003 and 2008. Doctors prescribed digoxin to 23 percent of the patients, and 70 percent of those patients were still on the drug one year later. Patients treated with digoxin were 1.2 times more likely to die than comparable patients prescribed other therapies. Patients receiving digoxin were more likely to die regardless of age; use of other drugs such as beta-blockers, amiodarone or warfarin; or the presence of other factors such as kidney disease, heart attack or heart failure, the study found.
The VA patient pool was predominantly male — only 1,980, or 1.6 percent, were female — and Turakhia has called for additional studies to establish whether the results are applicable to women as well.
Other Stanford co-authors are Wolfgang Winkelmayer, MD, ScD, associate professor of nephrology; Susan Frayne, MD, professor of medicine; Ciaran Phibbs, PhD, associate professor of pediatrics; and Paul Heidenreich, MD, professor of cardiovascular medicine. (J Am Coll Cardiol. 2014 Aug 19)
DIGOXIN Continued from page 1
Wolfgang Winkelmayer, MD
Paul Heidenreich, MD
Nanotechnology
Researchers Invent Nanotech Microchip to Diagnose Type-1 DiabetesBy Erin Digitale, Stanford Med. School Office of Communication
Sean Wu, MD, PhD, has been invited to join the editorial board of Circulation Research, a premiere basic cardiovascular research journal with an ISI impact factor of 11.86 (2012).
Editorial Board Additions
Better testing is needed because recent changes in who gets each form of the disease have made it risky to categorize patients based on their age, ethnicity or weight, as was common in the past, and also because of growing evidence that early, aggres-sive treatment of type-1 diabetes improves patients’ long-term prognoses. Decades ago, type-1 diabetes was diagnosed almost exclusively in children, and type-2 diabetes almost always in mid-dle-aged, overweight adults. Full story: http://goo.gl/rm2Qyc.
Brian Feldman, MD, PhD Photo by: Norbert von der Groeben
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Sex Differences
Cardiovascular disease is the leading cause of death in American women affecting more than 1 in 3 female adults.
Marcia Stefanick, Professor of Medicine, is co-director of Stanford’s Women and Sex Differences in Medicine (WSDM) center. The center focuses on women’s health and promotes the study of gender differences in basic and clinical research. Dr. Stefanick was Stanford’s leader, as Pricinpal Investigator and chair of the executive committee of the Women’s Health Initiative (WHI), a nation-wide endeavor, and one of the larg-est U.S. prevention studies of its kind. Established by the National Institute of Health (NIH) in 1991 WHI sought to address the most common cause of death, disability and impaired quality of life in postmenopausal women.
The hormone therapy component of the WHI trial aimed to examine the risks and benefits of menopausal hormone therapy on the prevention of heart disease and os-teoporosis, and any associated risk for breast cancer. Women participating in this part of the trail were given active estrogen, alone or combined with a progestin, pills or placebo (inactive pill). The trial, which ultimately enrolled 27,347 postmenopausal women age 50 to 79 years across 40 US centers led to a series of publications show-ing that the associated health risks of combination hormone therapy outweighed the benefits. The series of publications that stemmed from this work related to cardio-vascular disease are accessible at http://www.nhlbi.nih.gov/whi/references.htm#cvd.
Dr. Stefanick’s next mission is to develop strategies for healthy behavior. WHISH (Women’s Health Initiative Strong and Healthy) anticipated to begin in December 2014 aims to address the impact of physical activity in postmenopausal women 65 and older and will enroll greater then 50,000 women.
Sources: Women’s Health Initiative, National Institute of Health http://www.nhlbi.nih.gov/whi/factsht.htm; http://www.nhlbi.nih.gov/whi/background.htm
**Heart Disease and Stroke Statistics 2014 Update. Circulation. 2014;129:e28-e292. Go AS, Mozaffar-ian, D, Roger VL, Benjamin E J, et al. Heart Disease and Stroke Statistics 2014 Update: A Report from the American Heart Association Statistics Committee and Stroke Subcommittee.
“It would be simplistic to say we’re only studying men vs. women. We are studying the differences between women and men throughout the continuum of life’s many complex stages. ”
• More women than men die of cardio-vascular disease each year
• 64% of women and 50% of men who die suddenly from CHD had no previ-ous symptoms of this disease
• For women 35–44 years of age, the rate of death attributable to CHD has been increasing by an average of 1.3% annually while comparable rates among men have been falling
• Following a heart attack, 18% of women 45–64 years of age and 8% of men 45–64 will be diagnosed with heart failure within five years
• After a heart attack, women are 55% less likely than men to participate in cardiac rehabilitation
**Source for statistics
Women’s Heart
Girl’s Health
• An estimated 30.4% of girls age 2 to 19 are overweight or obese
• An estimated 63.7% of females age 20 and older are overweight or obese
• only 17.1% of adult women met the 2008 Federal Physical Activity Guidelines in 2012
Benchmarking Women’s Health Research
42.9 millionwomen currently living
with some form of cardiovascular disease
6.6 millionwomen alive today
with coronary heart disease and of these
2.6 millionwomen have a family history
of myocardial infarction
4.1 millionwomen will suffer from angina - Marcia L. Stefanick, PhD
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Dr. Paul Yock, Professor of Medicine and Bioengineering, is internationally known for his work in discovering and testing new medical devices, including the Rapid Exchange (tm) balloon angioplasty andstent system, now the primary system in
use worldwide. The Stanford Program in BioDesign initiated in 2001 was his creation as well. It’s a program focused on training the future leaders in biomedical technology. It facilitates con-ception of an idea to fulfill an immediate clinical need.
Thirty-three companies have been launched based on projects synthesized in the Biodesign Program, 275,000 patients have been impacted by their innovations and greater then 500 jobs created as of June 2014. These are just a few measures that
begin to describe the effectiveness of the Biodesign Program, where discovery is viewed as a process that if mastered can lead to invention. The ability to calculate risk and disengage upon critical assessment is highly valued.
Stanford has a legacy of pioneering innovations and disrupting markets and the incoming 2015 class in India will tackle a car-diovascular valvular need.
Recent publication with CVI member Dr. Peter Fitzgerald and Dr. Yasuhiro Honda: A Y-shaped bifurcation-dedicated stent for the treatment of de novo coronary bifurcation lesions: an IVUS analysis from the BRANCH trial. Sakata K. EuroIntervention. 2014 Aug 30.
Flies, Worms and Humans – and the modENCODE Project By Krista Conger, Office of Communication & Public Affairs at the School of Medicine
It’s a big day in comparative biology. Researchers around the country, including Stanford geneticist Michael Snyder, PhD, are publishing the results of a massive collaboration meant to suss out the genomic similari-ties (and differences) among model organisms like the fruit fly and the laboratory roundworm. A package of four papers, which describe how these organisms control how, when and where they express certain genes to generate the cell types necessary for complex life, appears today in Nature.
The research is an extension of the ENCODE, or Encyclopedia of DNA Elements, project that was initiated in 2003. As part of the large collaborative project, which was sponsored by the National Human Genome Research Institute, researchers published more than 4 million regulatory elements found within the human genome in 2012. Known as binding sites, these regions of DNA serve as landing pads for proteins and other molecules known as regulatory factors that control when and how genes are used to make proteins.
The new effort, known as modENCODE, brings a similar analysis to key model organisms like the fly and the worm. Snyder is the senior author of two of the papers published today describing some aspects of the modENCODE project, which has led to the pub-lication, or upcoming publication, of more than 20 papers in a variety of journals. The Nature papers, and the modENCODE project, are summarized in a News and Views article in the journal (subscription required to access all papers).
As Snyder said, “We’re trying to understand the basic principles that govern how genes are turned on and off. The worm and the fly have been the premier model organisms in biology for decades, and have provided the foundation for much of what we’ve learned about human biology. If we can learn how the rules of gene expression evolved over time, we can apply that knowledge to better understand human biology and disease.”
The researchers found that, although the broad strokes of gene regulation are shared among species, there are also significant differences. These differences may help explain why humans walk, flies fly and worms slither, for example:
The wealth of data from the modENCODE project will fuel research projects for decades to come, according to Snyder.
“We now have one of the most complete pictures ever generated of the regulatory regions and factors in several genomes,” said Snyder. “This knowledge will be invaluable to researchers in the field.”
Recent publications: Comparative analysis of regulatory information and circuits across distant species. Boyle AP et al. Nature. 2014 Aug 28; Regulatory analysis of the C. elegans genome with spatiotemporal resolution. Araya CL et al. Nature. 2014 Aug 2
Focus
“A a well-characterized need is the DNA of a good invention. It’s a lot of work to get the need right, but once you are there, the invention will almost certainly follow”
Paul Yock, MD
Michael Snyder, PhD
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Bioengineering and Chemical Engineering Building at Stanford Named for Gifts from Ram and Vijay Shriram By Lisa Lapin, University Communications
Stanford University will name a new home for bio-engineering and chemical engineering in recognition of gifts from university trustee Kavitark “Ram” Shriram and his wife, Vidjealatchoumy “Vijay”
Shriram. The couple have provided $57 million in support for the new Shriram Center for Bioengineering & Chemical Engi-neering, the fourth and final building in the university’s new Science and Engineering Quad. The Shrirams also will endow the departmental chair in the Department of Bioengineering, CVI member, Dr. Norbert Pelc, bringing their total philanthropic support in this area to $61 million.
Stanford has raised $78 million toward the total cost of the Shriram Center, including significant gifts from several other donors. The first occupants of the Shriram Center are scheduled to move in later this month.
“The Shriram Center will unite innovators in science, engineer-ing and medicine, enabling them to work together more closely and more quickly,” said John L. Hennessy, Stanford’s president. “We have also put teaching spaces at the very heart of the re-search facility, ensuring that future generations will be ready to realize the full potential of these fields. We are deeply grateful to Ram and Vijay for sharing our vision, and for the extraordi-nary generosity that is making the center a reality.”
Full story: http://news.stanford.edu/news/2014/june/building4-shriram-donors-061914.html
NIH Issues Finalized Policy on Genomic Data Sharing NIH Office of Communications
The National Institutes of Health has issued a final NIH Genom-ic Data Sharing (GDS) policy to promote data sharing as a way to speed the translation of data into knowledge, products and procedures that improve health while protecting the privacy of research participants. The final policy was posted in the Federal Register Aug. 26, 2014 and published in the NIH Guide for Grants and Contracts Aug. 27, 2014.
Genomic Data Sharing Policy
Starting with funding applications submit-ted for a Jan. 25, 2015, receipt date, the policy will apply to all NIH-funded, large-scale hu-man and non-human projects that gener-ate genomic data. This includes research conducted with the
support of NIH grants and contracts and within the NIH Intramu-ral Research Program. NIH officials finalized the policy after re-viewing public comments on a draft released in September 2013.
The GDS policy can be traced to the Human Genome Project, completed in 2003, which required rapid and broad data release during its mapping and sequencing of the human genome. The GDS policy is an extension of and replaces the Genome-Wide As-sociation Studies (GWAS) data sharing policy.
For complete information about genomic data sharing and a link to the GDS policy, see http://www.nih.gov/news/health/aug2014/od-27.htm
2014 ARR Distinguished Investigators Award by Amy N. Thomas, Stanford Radiology
The Academy of Radiology Re-search announced Distinguished Investigators for 2014. This presti-gious honor recognizes individuals for their accomplishments in the field of imaging research. Over the past few decades, the radiology research community has been re-sponsible for many important ad-vances that have had a profound impact on healthcare.
The Academy Induction Ceremony will take place at this year’s RSNA (Radiology Society of North America) annual meeting in November. Congratulations to Stanford Radiology Faculty who are among those named as 2014 Distinguished Investigators.
Gary Glover, PhD Brian Hargreaves, PhD Norbert Pelc, ScD Joseph Wu, MD, PhD
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Stanford Partnering with Google [X] and Duke to Better Understand the Human Body By Ruthann Richter, Office of Communication & Public Affairs at the School of Medicine
The Gene Team By Sara Wykes, Office of Communication & Public Affairs at the School of Medicine
Stanford’s hospitals have launched a new testing service for their patients that de-ciphers their DNA. The clinical genomic service will help doctors at Stanford Hospital & Clinics and Lucile Packard Children’s Hospital Stanford diagnose and treat genetic conditions. With this, Stanford joins a small group of medical centers—about 15—that provide genome sequencing.
During its pilot phase, testing will be lim-ited to patients with inherited cardiovas-cular or neurological disease, hereditary cancer risk, unexplained drug reactions or an illness that has defied diagnosis. Its directors are Euan Ashley, MCRP, DPhil, associate professor of medicine and of genetics, and Jason Merker, MD, PhD, as-sistant professor of pathology.
In 2010, Ashley and bioengineering professor Stephen Quake, PhD, used a healthy person’s genome sequence to predict dis-ease and anticipate reaction to several common medications. These new genomic services are the first wave to test this new knowledge.
Partnerships
Detection Without Radiation by Erin Digitale, Office of Communication & Public Affairs at the School of Medicine
After learning they have cancer, lymphoma patients usually get scans to locate tumors throughout their bodies. But the standard imaging method, whole-body PET-CT, has a big drawback: One scan exposes the patient to as much ionizing radiation as 700 chest X-rays.
This is especially risky for children and teenagers, who are particularly vulnerable to radiation because they are growing. They are also more likely than adults to live long enough afterward to develop a secondary cancer. That’s why researchers at the School of Medicine and Lucile Packard Children’s Hospital Stanford developed an imaging tech-nique that uses no radiation at all. The method, described in The Lancet Oncology, is a
modification of magnetic resonance imaging that employs a novel contrast agent.
Sam Gambhir, MD, PhD
Euan Ashley, MD, PhD
Stephen Quake, PhD
Most biomedical research is focused on disease and specific treatments for ill-ness, rather than on understanding what it means to be healthy. Now researchers at Stanford, in collaboration with Duke University and Google [x], are planning a comprehensive initiative to understand the molecular markers that are key to health and the changes in those biomark-ers that may lead to disease. The project
was featured in a Wall Street Journal article.
The study is at the very early stages, with researchers planning to enroll 175 healthy participants in a pilot trial later this year. The participants will undergo a physical exam and provide sam-ples of blood, saliva and other body fluids that can be examined using new molecular testing tools, such as genome sequencing. The pilot study will help the researchers design and conduct a much larger trial in the future.
“The study being planned will allow us to better understand the variation of many biomarkers in the normal population and what parameters are predictive of illness and may eventually change as a given individual transitions from a healthy to a diseased state. This will be a critical study that will likely help the field of health care for decades to come,” said Gambhir, who also directs the Canary Center at Stanford for Cancer Early Detection.
The work is sponsored by Google [x] and will be led by Andrew Conrad, PhD, a cell biologist and project manager at the company.
“We continue as a global community to think about health primarily only after becoming ill...To understand health and illness effectively, we have to have a better understanding of what ‘normal’ or ‘healthy’ really means at the biochemical level.”
6th Annual NHLBI
Progenitor Cell Biology Consortium Meeting
September 29-30, 2014 Li Ka Shing Center for Learning & Knowledge, Stanford University
Sponsored by: NIH, Stanford Cardiovascular Institute, Vera Moulton Wall Center and Stanford Institute for Stem Cell Biology and Regenerative Medicine
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Funding Opportunites
Helen M. Blau, PhD“Mass Cytometry to Delin-
eate the Human Muscle Stem Cell Hierarchy and
Dysfunction in Aging”
Seung K. Kim, MD, PhD ‘Induction of PDGF signal-ing to regenerate human
beta cells’
FACULTY
NIH-RO1 Improvement of Animal Models for Stem Cell-based Regenerative Medicine Deadline: Oct. 5, 2014
Research Project Grant (Parent R01) Deadline: Oct. 5, 2014
Innovator Award- Progeria Research Foundation Amount of funding: $75K for 2 years Deadline: Oct. 27, 2014
Progeria Research Foundation Established Investigator Award Amount of funding: $100K for 3 years Deadline: Oct. 27, 2014
Data Science and Applications- Stanford University Deadline: Sept. 30, 2014 (LOI)
Spectrum Pilot Grant Amount of funding: $15-50K for 1 year Deadline: Sept. 30, 2014 (LOI)
POSTDOCTORAL FELLOWS
K01 Mentored Research Scientist Development Awards Deadline: Oct. 12, 2014
K08 Mentored Clinical Research Career Development Award Deadline: Oct. 12, 2014
K23 Mentored Patient-Oriented Research Career Development Award Deadline: Oct. 12, 2014
K99/R00 NIH Pathway to Independence Award Deadline: Oct. 12, 2014
Postdoctoral Research Fellowship- A.P. Giannini Foundation Amount of funding: $46-50K for 3 years Deadline: Nov. 3, 2014
Prevention Research Center Fellowship - Stanford University Deadline: Nov. 15, 2014
Kirschstein National Research Service Award (F32) Deadline: Dec. 8, 2014
ACCF Young Investigator Award-American College of Cardiology Amount of funding: $2K Deadline: Sept. 15, 2014
ACCF / William F. Keating, Esq. Endowment Career Development Award Amount of funding: $70K for 1 year Deadline: Sept. 22, 2014
Travel and Exchange Ideas! CVI Award
CIRM
Faculty Highlights
Juvenile Diabetes Foundation
Michael V. McConnell, MD‘Multi-Disciplinary Training Program in Cardiovascular
Imaging at Stanford’
Daria Mochly-Rosen, PhD‘Mechanisms of Ethanol-In-duced Cardiac Protection’
Jill Helms, PhD“Mechanobiology at Healing Bone-
Implant Interfaces”
Joshua W. Knowles, MD has been appointed ASSISTANT
PROFESSOR OF MEDICINE Prevention and Stanford Center for Inherited
Cardiovascular Disease.
Christopher Cheng, MDis now the Director of the
Vascular InterventionBiomechanics
& Engineering Lab
Alan Yuen Yeung, MDIs working to assess the
Improvement of Interventional Devices for Cardiovascular Disease
- Imaging Evaluation.
William F. Fearon, MD working with St. Jude Medical
Cardiovascular Division on Portico TM Re-sheathable Transcatheter Aortic Valve System US IDE Trial
(PORTICO).
Recently Funded Projects (June–August)
cvi.stanford.edu/research/travel_grant_awards.html
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2014-2015 CVI Frontiers in Cardiovascular Science
12 noon - 1 p.m., Frontiers Tuesdays, Starting Sept. 9, 2014, Li Ka Shing Center Public is Welcome. For information please e-mail [email protected]
2014Howard Bachner, MD 9/9/2014 Editor in Chief, JAMA and The JAMA Network
Norbert Voelkel, MD 9/16/2014Professor (Affiliate), School of Pharmacy, Virginia Commonwealth U.
Roy Vagelos, MD 9/23/2014Former President and CEO of Merck
Kenneth Mahaffey, MD 10/7/2014Stanford, Vice Chair of Clinical Research
Ronald Dalman, MD 10/14/2014Stanford, Chief, Division of Vascular Surgery
Jonathan R. Lindner, MD 10/21/2014Professor of Cardiology, Knight Cardiovascular Institute
John F. Keaney, Jr., MD 10/28/2014Chief, Div. Cardiovascular Med. U. Mass Memorial Med. Center
Bernard Gersh, MB, ChB, DPhil 11/11/2014Mayo Clinic
Mintu Turakhia, MD 11/25/2014Stanford, Director Cardiac Electrophysiology VA Palo Alto
Joseph Hill, MD, PhD 12/9/2014Chair in Cardiovascular Diseases, UT Southwestern
Irv Weissman, MD 12/16/2014Director Stanford Institute for Stem Cell Biology & Regenerative Medicine
2015Beth Pruitt, PhD 1/13/2015Stanford, Associate Professor of Mechanical Engineering
Eric Olson, PhD 1/20/2015Professor and Chair, UT Southwestern
Richard Lawn, PhD 1/27/2015Stanford, CVI Consulting Professor
Roberto Bolli, MD 2/3/2015Professor and Chief Division of Cardiology, U. Louisville
Kristine Red-Horse, PhD 2/10/2015 Stanford, Assistant Professor Dept. of Biology
Garrett Fitzgerald, MD 2/17/2015Professor of Medicine and Pharmacology, U. Penn.
Jeffery D. Molkentin, PhD 2/24/2015 Professor, Children’s Hospital Medical Center, HHMI Investigator
Andrew Plump, MD, PhD 3/3/2015 Deputy to the President Global R&D, Sanofi
James T. Willerson, MD 3/10/2015President and Medical Director, Texas Heart Institute
Joseph Loscalzo, MD, PhD 3/17/2015Chair, Dept. of Medicine, Brigham and Women’s Hospital
Leslie Leinwand, PhD 4/21/2015Prof., Molecular, Cellular & Developmental Biology, U. Colorado-Boulder
Junichi Sadoshima, MD, PhD 4/28/2015 Professor, Cell Biology & Molecular Medicine, Rutgers U.
Western Vascular Society September 20-23, 2014 Coronado, CA
Vascular Biology (NAVBO – North American Vascular Biology) October 19-23, 2014 Monterey, CA
AHA ReSuscitation Science Symposium November 15-16, 2014 Chicago, Illinois
AHA Cardiovascular and Stroke Nursing Symposium November 18-19, 2014 Chicago, Illinois
AHA Scientific Sessions 2014 November 19-20, 2014 Chicago, Illinois
VEITH-Vascular Endovascular Issues Techniques Horizons November 18-22, 2014 New York, NY
Cardiovascular Conferences
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HEALTHY LIVING STARTS HERECommunity Health Fair / Palo Alto YMCASaturday, September 13, 20142:00 – 5:00 p.m.River of Life Christian Church1177 Laurelwood Road, Santa Clara, CA 95054
You’re welcome to join this special health and wellness event featuring:
• Panels & Workshops with Doctors and Medical Professionals
• Group Exercise demonstrations
• Ask-a-Doctor Booth
• Wellness consultations
For more information contact: Lorraine Hart at 650.842.2706 or [email protected]
Sponsored by the YMCA, River of Life Foundation & Stanford CVI
Community Events
The CVI is walking for healthy hearts.2014 Silicon Valley Heart & Stroke Walk
October 11, 2014 KLA-Tencor Campus
1 Technology Drive, Milpitas, CA 95035 Join our team or donate!
The Heart Walk is the American Heart Associa-tion’s premiere event for raising funds to save lives from this country’s No. 1 and No. 4 killers - heart disease and stroke. Designed to promote physical activity and heart-healthy living, the Heart Walk creates an environment that’s fun and rewarding for the entire family.
The faculty and staff of the Vera Moulton Wall Center are proud to present the 14th Annual Race Against PH. A 3.1 mile race dedicated to raising funds and awareness for the fight against pulmonary hypertension (PH).
From competitive runners to casual walkers, everyone is welcome. Recruit your family, friends, and colleagues to join you. Support a great cause while enjoying the beautiful Stanford campus. We hope to see you on November 2nd and THANK YOU for your support!
Presented by
scan to gETstarted
raceagainstph.org register now!
FA L L 2 0 1 4 | 12
Molecular diagnosis of long QT syndrome at 10 days of life by rapid
whole genome sequencing. Priest JR, Ceresnak SR, Dewey FE, Malloy-
Walton LE, Dunn K, Grove ME, Perez MV, Maeda K, Dubin AM, Ashley EA. Heart Rhythm. 2014 Jun 25
Human stem cells for modeling heart disease and for drug discovery.
Matsa E, Burridge PW, Wu JC. Sci Transl Med. 2014 Jun 4;6(239):239ps6
A bioengineered hydrogel system enables targeted and sustained
intramyocardial delivery of neuregulin, activating the cardiomyocyte
cell cycle and enhancing ventricular function in a murine model of
ischemic cardiomyopathy. Cohen JE, Purcell BP, MacArthur JW Jr, Mu
A, Shudo Y, Patel JB, Brusalis CM, Trubelja A, Fairman AS, Edwards BB,
Davis MS, Hung G, Hiesinger W, Atluri P, Margulies KB, Burdick JA, Woo YJ. Circ Heart Fail. 2014 Jul;7(4):619-26
Current clinical management of pulmonary arterial hyperten-
sion. Zamanian RT, Kudelko KT, Sung YK, de Jesus Perez V, Liu J,
Spiekerkoetter E. Circ Res. 2014 Jun 20;115(1):131-47
Causes of mortality with ticagrelor compared with clopidogrel in acute
coronary syndromes. Varenhorst C, Alström U, Braun OO, Storey RF,
Mahaffey KW, Bertilsson M, Cannon CP, Scirica BM, Himmelmann A,
James SK, Wallentin L, Held C. Heart. 2014 Jun 23
Targeting the Wnt signaling pathways in pulmonary arterial hyperten-
sion. de Jesus Perez V, Yuan K, Alastalo TP, Spiekerkoetter E, Rabino-vitch M. Drug Discov Today. 2014 Aug;19(8):1270-1276
Antiplatelet and anticoagulation therapy for acute coronary syn-
dromes. Bhatt DL, Hulot JS, Moliterno DJ, Harrington RA. Circ Res.
2014 Jun 6;114(12):1929-43
New ways to dismantle a ticking time bomb: microRNA 712/205 and
abdominal aortic aneurysm development. Maegdefessel L, Spin JM,
Tsao PS. Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1339-40
Completion of the Three-Stage Fontan Pathway Without Cardiopulmo-
nary Bypass. Mainwaring RD, Reddy VM, Hanley FL. World J Pediatr
Congenit Heart Surg. 2014 Jun 23;5(3):427-433
Circulating cell-free DNA enables noninvasive diagnosis of heart
transplant rejection. De Vlaminck I, Valantine HA, Snyder TM, Strehl
C, Cohen G, Luikart H, Neff NF, Okamoto J, Bernstein D, Weisshaar D,
Quake SR, Khush KK. Sci Transl Med. 2014 Jun 18;6(241):241ra77
Controlling low rates of cell differentiation through noise and ultrahigh
feedback. Ahrends R, Ota A, Kovary KM, Kudo T, Park BO, Teruel MN.
Science. 2014 Jun 20;344(6190):1384-9
Thermal regulation for APDs in a 1 mm(3) resolution clinical PET cam-
era: design, simulation and experimental verification. Zhai J, Vanden-
broucke A, Levin CS. Phys Med Biol. 2014 Jul 21;59(14):3951-67
Effect of salsalate on insulin action, secretion, and clearance in nondi-
abetic, insulin-resistant individuals: a randomized, placebo-controlled
study. Kim SH, Liu A, Ariel D, Abbasi F, Lamendola C, Grove K, Tomasso
V, Ochoa H, Reaven G. Diabetes Care. 2014 Jul;37(7):1944-50
Anesthesia and the developing brain: relevance to the pediatric cardiac
surgery. Wise-Faberowski L, Quinonez ZA, Hammer GB. Brain Sci. 2014
Apr 16;4(2):295-310
Trial to Assess Chelation Therapy (TACT) and equipoise: When evi-
dence conflicts with beliefs. Maron DJ, Hlatky MA. Am Heart J. 2014
Jul;168(1):4-5
Integrated surgical residency initiative: implications for cardiothoracic
surgery. Ikonomidis JS, Crawford FA Jr, Fann JI. Semin Thorac Cardio-
vasc Surg. 2014 Spring;26(1):14-23
Inflammation and immunity in the pathogenesis of pulmonary arterial
hypertension. Rabinovitch M, Guignabert C, Humbert M, Nicolls MR.
Circ Res. 2014 Jun 20;115(1):165-75
Ultrafast fluorescence imaging in vivo with conjugated polymer fluo-
rophores in the second near-infrared window. Hong G, Zou Y, Antaris
AL, Diao S, Wu D, Cheng K, Zhang X, Chen C, Liu B, He Y, Wu JZ, Yuan J,
Zhang B, Tao Z, Fukunaga C, Dai H. Nat Commun. 2014 Jun 20;5:4206
Application of Finite Element Modeling to Optimize Flap Design with
Tissue Expansion. Buganza-Tepole A, Steinberg JP, Kuhl E, Gosain AK.
Plast Reconstr Surg. 2014 Jun 18
Cardiorespiratory fitness and the paradoxical BMI-mortality risk associa-
tion in male veterans. Kokkinos P, Faselis C, Myers J, Pittaras A, Sui X,
Zhang J, McAuley P, Kokkinos JP. Mayo Clin Proc. 2014 Jun;89(6):754-62
Age-specific exercise capacity threshold for mortality risk assessment
in male veterans. Kokkinos P, Faselis C, Myers J, Sui X, Zhang J, Blair
SN. Circulation. 2014 Aug 19;130(8):653-8
Warfarin, genes, and the (health care) environment. Kazi DS, Hlatky MA. JAMA Intern Med. 2014 Aug 1;174(8):1338-9
Chemically defined generation of human cardiomyocytes. Burridge PW, Matsa E, Shukla P, Lin ZC, Churko JM, Ebert AD, Lan F, Diecke S,
Huber B, Mordwinkin NM, Plews JR, Abilez OJ, Cui B, Gold JD, Wu JC.
Nat Methods. 2014 Aug;11(8):855-60
How does morphology impact on diastolic function in hypertrophic
cardiomyopathy? A single centre experience. Finocchiaro G, Haddad F,
Pavlovic A, Magavern E, Sinagra G, Knowles JW, Myers J, Ashley EA.
BMJ Open. 2014 Jun 12;4(6):e004814
Member Publications
JUNE 116 Publications
Communication is at the heart of scientific advancement and innovation. This quarter Stanford Cardiovascular Institute members published over a hundred original manuscripts and reviews further contributing to our understanding of cardiovascular biology and disease. In the following pages we highlight selected manuscripts by our members.
FA L L 2 0 1 4 | 13
Individual differences in field independence influence the ability to de-
termine accurate needle angles. Sheikh AY, Keehner M, Walker A, Chang
PA, Burdon TA, Fann JI. J Thorac Cardiovasc Surg. 2014 May 9
Tolerance: one transplant for life. Kawai T, Leventhal J, Madsen JC,
Strober S, Turka LA, Wood KJ. Transplantation. 2014 Jul 27;98(2):117-21
Comparative definitions for moderate-severe ischemia in stress
nuclear, echocardiography, and magnetic resonance imaging. Shaw LJ,
Berman DS, Picard MH, Friedrich MG, Kwong RY, Stone GW, Senior R,
Min JK, Hachamovitch R, Scherrer-Crosbie M, Mieres JH, Marwick TH,
Phillips LM, Chaudhry FA, Pellikka PA, Slomka P, Arai AE, Iskandrian
AE, Bateman TM, Heller GV, Miller TD, Nagel E, Goyal A, Borges-Neto S,
Boden WE, Reynolds HR, Hochman JS, Maron DJ, Douglas PS; National
Institutes of Health/National Heart, Lung, and Blood Institute-Spon-
sored ISCHEMIA Trial Investigators. JACC Cardiovasc Imaging. 2014
Jun;7(6):593-604
B-type natriuretic peptide predicts 30-day readmission for heart failure
but not readmission for other causes. Flint KM, Allen LA, Pham M,
Heidenreich PA. J Am Heart Assoc. 2014 Jun 10;3(3):e000806
Identification of a new modulator of the intercalated disc in a zebraf-
ish model of arrhythmogenic cardiomyopathy. Asimaki A, Kapoor S,
Plovie E, Karin Arndt A, Adams E, Liu Z, James CA, Judge DP, Calkins H,
Churko J, Wu JC, MacRae CA, Kléber AG, Saffitz JE. Sci Transl Med. 2014
Jun 11;6(240):240ra74
Hemocompatibility evaluation of small elastomeric hollow fiber mem-
branes as vascular substitutes. Mercado-Pagán AE, Ker DF, Yang Y. J
Biomater Appl. 2014 Jun 9
Reentry Device Aided Endovascular Aneurysm Repair in Patients with
Abdominal Aortic Aneurysm and Unilateral Iliac Artery Occlusion. Varu
VN, Lee GK, Chang S, Lee JT. Ann Vasc Surg. 2014 Jun 6
Statins and physical activity in older men: the osteoporotic fractures
in men study. Lee DS, Markwardt S, Goeres L, Lee CG, Eckstrom E, Wil-
liams C, Fu R, Orwoll E, Cawthon PM, Stefanick ML, Mackey D, Bauer
DC, Nielson CM. JAMA Intern Med. 2014 Aug 1;174(8):1263-70
Muscarinic acetylcholine receptors: novel opportunities for drug devel-
opment. Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A,
Wess J. Nat Rev Drug Discov. 2014 Jul;13(7):549-60
Tirone David procedure for bicuspid aortic valve disease: impact of
root geometry and valve type on mid-term outcomes†. Kari FA, Kvitting
JP, Stephens EH, Liang DH, Merk DR, Fischbein MP, Mitchell RS, Miller DC. Interact Cardiovasc Thorac Surg. 2014 Sep;19(3):375-81
Efficacy and safety of rivaroxaban compared with warfarin among
elderly patients with nonvalvular atrial fibrillation in the Rivaroxa-
ban Once Daily, Oral, Direct Factor Xa Inhibition Compared With
Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in
Atrial Fibrillation (ROCKET AF). Halperin JL, Hankey GJ, Wojdyla DM,
Piccini JP, Lokhnygina Y, Patel MR, Breithardt G, Singer DE, Becker
RC, Hacke W, Paolini JF, Nessel CC, Mahaffey KW, Califf RM, Fox KA;
ROCKET AF Steering Committee and Investigators. Circulation. 2014 Jul
8;130(2):138-46
Inducing myointimal hyperplasia versus atherosclerosis in mice: an
introduction of two valid models. Stubbendorff M, Hua X, Deuse T, Ali
Z, Reichenspurner H, Maegdefessel L, Robbins RC, Schrepfer S. J Vis
Exp. 2014 May 14;(87)
Guidelines for cardiovascular risk assessment and cholesterol treat-
ment--reply. Ioannidis JP. JAMA. 2014 Jun 4;311(21):2235-6
Association between prophylactic implantable cardioverter-defibril-
lators and survival in patients with left ventricular ejection fraction
between 30% and 35%. Al-Khatib SM, Hellkamp AS, Fonarow GC, Mark
DB, Curtis LH, Hernandez AF, Anstrom KJ, Peterson ED, Sanders GD, Al-
Khalidi HR, Hammill BG, Heidenreich PA, Hammill SC. JAMA. 2014 Jun
4;311(21):2209-15
A new dual threshold time-over-threshold circuit for fast timing in PET.
Grant AM, Levin CS. Phys Med Biol. 2014 Jul 7;59(13):3421-30
Insulin resistance: regression and clustering. Yoon S, Assimes TL, Quertermous T, Hsiao CF, Chuang LM, Hwu CM, Rajaratnam B, Olshen RA. PLoS One. 2014 Jun 2;9(6):e94129
The effects of varying poly(ethylene glycol) hydrogel crosslinking den-
sity and the crosslinking mechanism on protein accumulation in three-
dimensional hydrogels. Lee S, Tong X, Yang F. Acta Biomater. 2014 Jun 2
Two nested developmental waves demarcate a compartment bound-
ary in the mouse lung. Alanis DM, Chang DR, Akiyama H, Krasnow MA,
Chen J. Nat Commun. 2014 May 29;5:3923
Predicted shortfall in open aneurysm experience for vascular surgery
trainees. Dua A, Upchurch GR Jr, Lee JT, Eidt J, Desai SS. J Vasc Surg.
2014 May 27
JULY 85 Publications
Human induced pluripotent stem cell-derived cardiomyocytes as an
in vitro model for coxsackievirus b3-induced myocarditis and antiviral
drug screening platform. Sharma A, Marceau C, Hamaguchi R, Burridge PW, Rajarajan K, Churko JM, Wu H, Sallam KI, Matsa E, Sturzu AC, Che
Y, Ebert A, Diecke S, Liang P, Red-Horse K, Carette JE, Wu SM, Wu JC.
Circ Res. 2014 Aug 29;115(6):556-66.
Second Generation Codon Optimized Minicircle (CoMiC) for Nonviral
Reprogramming of Human Adult Fibroblasts. Diecke S, Lisowski L,
Kooreman NG, Wu JC. Methods Mol Biol. 2014;1181:1-13
Electrocardiographic Repolarization-Related Variables as Predictors of
Coronary Heart Disease Death in the Women’s Health Initiative Study.
Rautaharju PM, Zhang ZM, Vitolins M, Perez M, Allison MA, Greenland P,
Soliman EZ. J Am Heart Assoc. 2014 Jul 28;3(4)
Vein Graft Preservation Solutions, Patency, and Outcomes After
Coronary Artery Bypass Graft Surgery: Follow-up From the PREVENT
IV Randomized Clinical Trial. Harskamp RE, Alexander JH, Schulte PJ,
Brophy CM, Mack MJ, Peterson ED, Williams JB, Gibson CM, Califf RM,
Kouchoukos NT, Harrington RA, Ferguson TB Jr, Lopes RD. JAMA Surg.
2014 Aug 1;149(8):798-805
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Functional assessment of multivessel coronary artery disease:
ischemia-guided percutaneous coronary intervention. Schwartz JG,
Fearon WF. Coron Artery Dis. 2014 Sep;25(6):521-8
Advances in understanding percutaneous coronary intervention phar-
macology: ischemia, bleeding, the ISAR research group, and a com-
mitment to progress. Harrington RA, Popma CJ, Gibson CM. Coron
Artery Dis. 2014 Sep;25(6):453-5
Co-occurrence of a cerebral cavernous malformation and an orbital
cavernous hemangioma in a patient with seizures and visual symp-
toms: Rare crossroads for vascular malformations. Choudhri O, Feroze
AH, Lad EM, Kim JW, Plowey ED, Karamchandani JR, Chang SD. Surg
Neurol Int. 2014 Jun 19;5(Suppl 4):S148-54
Combined Heart and Liver Transplantation Can Be Safely Performed
With Excellent Short- and Long-Term Results. Atluri P, Gaffey A, How-
ard J, Phillips E, Goldstone AB, Hornsby N, MacArthur JW, Cohen JE,
Gutsche J, Woo YJ. Ann Thorac Surg. 2014 Jul 25
Studies in Fat Grafting: Part III. Fat Grafting Irradiated Tissue-Im-
proved Skin Quality and Decreased Fat Graft Retention. Garza RM,
Paik KJ, Chung MT, Duscher D, Gurtner GC, Longaker MT, Wan DC.
Plast Reconstr Surg. 2014 Aug;134(2):249-57
A human pluripotent stem cell surface N-glycoproteome resource
reveals markers, extracellular epitopes, and drug targets. Boheler
KR, Bhattacharya S, Kropp EM, Chuppa S, Riordon DR, Bausch-Fluck
D, Burridge PW, Wu JC, Wersto RP, Chan GC, Rao S, Wollscheid B,
Gundry RL. Stem Cell Reports. 2014 Jun 6;3(1):185-203
Aortic Arch Vessel Geometries and Deformations in Patients with
Thoracic Aortic Aneurysms and Dissections. Suh GY, Beygui RE, Fleis-chmann D, Cheng CP. J Vasc Interv Radiol. 2014 Jul 22
Association of metabolic syndrome and its individual components
with outcomes among patients with high-risk non-ST-segment
elevation acute coronary syndromes. Mehta RH, Westerhout CM,
Zheng Y, Giugliano RP, Huber K, Prabhakaran D, Harrington RA,
Newby KL, Armstrong PW; EARLY ACS Investigators. Am Heart J. 2014
Aug;168(2):182-188.e1
Outcomes registry for better informed treatment of atrial fibrilla-
tion II: Rationale and design of the ORBIT-AF II registry. Steinberg
BA, Blanco RG, Ollis D, Kim S, Holmes DN, Kowey PR, Fonarow GC,
Ansell J, Gersh B, Go AS, Hylek E, Mahaffey KW, Thomas L, Chang P,
Peterson ED, Piccini JP; ORBIT-AF Steering Committee Investigators.
Am Heart J. 2014 Aug;168(2):160-7
Independent data monitoring committees: Preparing a path for the
future. Hess CN, Roe MT, Gibson CM, J Temple R, Pencina MJ, Zarin
DA, Anstrom KJ, Alexander JH, Sherman RE, Fiedorek FT, Mahaffey KW, Lee KL, Chow SC, Armstrong PW, Califf RM. Am Heart J. 2014
Aug;168(2):135-141.e1.
Justification of an Introductory ECG Teaching Mnemonic by Demon-
stration of its Prognostic value. Soofi M, Yong C, Froelicher VF. Am J
Med. 2014 Jul 24
HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the
mitochondrial permeability transition pore. Ong SG, Lee WH, Theodorou
L, Kodo K, Lim SY, Shukla DH, Briston T, Kiriakidis S, Ashcroft M, Davidson
SM, Maxwell PH, Yellon DM, Hausenloy DJ. Cardiovasc Res. 2014 Jul 25
Genomics in clinical practice. Priest JR, Ashley EA. Heart. 2014 Jul 25
Caregiving Frequency and Physical Function: The Women’s Health Ini-
tiative. Rosso AL, Lee BK, Stefanick ML, Kroenke CH, Coker LH, Woods
NF, Michael YL. J Gerontol A Biol Sci Med Sci. 2014 Jul 24
Comparative Potential of Juvenile and Adult Human Articular Chon-
drocytes for Cartilage Tissue Formation in 3D Biomimetic Hydrogels.
Smeriglio P, Lai JH, Dhulipala L, Behn AW, Goodman SB, Smith RL,
Maloney W, Yang F, Bhutani N. Tissue Eng Part A. 2014 Jul 23
Genetic evidence for a normal-weight “metabolically obese” pheno-
type linking insulin resistance, hypertension, coronary artery disease
and type 2 diabetes. Yaghootkar H, Scott RA, White CC, Zhang W,
Speliotes E, Munroe PB, Ehret GB, Bis JC, Fox CS, Walker M, Borecki
IB, Knowles JW, Yerges-Armstrong L, Ohlsson C, Perry JR, Chambers
JC, Kooner JS, Franceschini N, Langenberg C, Hivert MF, Dastani Z,
Richards JB, Semple RK, Frayling TM. Diabetes. 2014 Jul 21
Collateral vessel number, plaque burden, and functional decline in
peripheral artery disease. McDermott MM, Carr J, Liu K, Kramer CM,
Yuan C, Tian L, Criqui MH, Guralnik JM, Ferrucci L, Zhao L, Xu D, Kibbe
M, Berry J, Carroll TJ. Vasc Med. 2014 Jul 21;19(4):281-288
Influence of the stiffness of three-dimensional alginate/collagen-I
interpenetrating networks on fibroblast biology. Branco da Cunha C,
Klumpers DD, Li WA, Koshy ST, Weaver JC, Chaudhuri O, Granja PL,
Mooney DJ. Biomaterials. 2014 Oct;35(32):8927-36
Top-Down Patterning and Self-Assembly for Regular Arrays of Semi-
conducting Single-Walled Carbon Nanotubes. Wu J, Antaris A, Gong M,
Dai H. Adv Mater. 2014 Jul 22. doi: 10.1002/adma.201401108
Visualization of arrestin recruitment by a G-protein-coupled receptor.
Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla
P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL,
Shan JM, Chen X, Hanna R, Choi M, Yao XJ, Klink BU, Kahsai AW, Sidhu
SS, Koide S, Penczek PA, Kossiakoff AA, Woods VL Jr, Kobilka BK, Ski-
niotis G, Lefkowitz RJ. Nature. 2014 Aug 14;512(7513):218-22
Immediate Postoperative Percutaneous Stenting of Superior Vena
Cava Obstruction Following Heart Transplantation in Adult Patients
with Pacemaker Leads. Asseff D, Sheikh AY, Sze D, Ha R, Hofmann L,
van der Starre PJ. J Card Surg. 2014 Jul 8. doi: 10.1111/jocs.12387
A plasmonic chip for biomarker discovery and diagnosis of type 1
diabetes. Zhang B, Kumar RB, Dai H, Feldman BJ. Nat Med. 2014
Aug;20(8):948-53
Capillary Force Seeding of Hydrogels for Adipose-Derived Stem
Cell Delivery in Wounds. Garg RK, Rennert RC, Duscher D, Sorkin
M, Kosaraju R, Auerbach LJ, Lennon J, Chung MT, Paik K, Nimpf J,
Rajadas J, Longaker MT, Gurtner GC. Stem Cells Transl Med. 2014
Sep;3(9):1079-1089
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Developmental Heterogeneity of Cardiac Fibroblasts Does Not Predict
Pathological Proliferation and Activation. Ali SR, Ranjbarvaziri S,
Talkhabi M, Zhao P, Subat A, Hojjat A, Kamran P, Müller AM, Volz KS,
Tang Z, Red-Horse K, Ardehali R. Circ Res. 2014 Jul 18
CE: Sustaining Pressure Ulcer Best Practices in a High-Volume Cardiac
Care Environment. Paul R, McCutcheon SP, Tregarthen JP, Denend LT,
Zenios SA. Am J Nurs. 2014 Aug;114(8):34-44
Beta-blocker therapy and cardiac events among patients with newly
diagnosed coronary heart disease. Andersson C, Shilane D, Go AS,
Chang TI, Kazi D, Solomon MD, Boothroyd DB, Hlatky MA. J Am Coll
Cardiol. 2014 Jul 22;64(3):247-52
Integrative genomics reveals novel molecular pathways and gene
networks for coronary artery disease. Mäkinen VP, Civelek M, Meng Q,
Zhang B, Zhu J, Levian C, Huan T, Segrè AV, Ghosh S, Vivar J, Nikpay
M, Stewart AF, Nelson CP, Willenborg C, Erdmann J, Blakenberg S,
O’Donnell CJ, März W, Laaksonen R, Epstein SE, Kathiresan S, Shah SH,
Hazen SL, Reilly MP; Coronary ARtery DIsease Genome-Wide Replica-
tion And Meta-Analysis (CARDIoGRAM) Consortium, Lusis AJ, Samani
NJ, Schunkert H, Quertermous T, McPherson R, Yang X, Assimes TL.
PLoS Genet. 2014 Jul 17;10(7):e1004502
Serum profiling using protein microarrays to identify disease related
antigens. Sharon D, Snyder M. Methods Mol Biol. 2014;1176:169-78
Exploring the world of human development and reproduction.
Red-Horse K, Drake PM, Fisher S. Int J Dev Biol. 2014;58(2-4):87-93
HELOW: A program for testing extreme homogeneity in meta-analysis.
Zintzaras E, Ioannidis JP. Comput Methods Programs Biomed. 2014 Jun 23
Prognostic Value of Fasting Versus Nonfasting Low-Density Lipoprotein
Cholesterol Levels on Long-Term Mortality: Insight From the National
Health and Nutrition Examination Survey III (NHANES-III). Doran B, Guo
Y, Xu J, Weintraub H, Mora S, Maron DJ, Bangalore S. Circulation. 2014
Aug 12;130(7):546-53
Lung Volume Reduction After Stereotactic Ablative Radiation Therapy
of Lung Tumors: Potential Application to Emphysema. Binkley MS, Sh-rager JB, Leung AN, Popat R, Trakul N, Atwood TF, Chaudhuri A, Maxim
PG, Diehn M, Loo BW Jr. Int J Radiat Oncol Biol Phys. 2014 Jul 8. pii:
S0360-3016(14)00625-7
Mammalian target of rapamycin cell signaling pathway contrib-
utes to the protective effects of ischemic postconditioning against
stroke. Xie R, Wang P, Cheng M, Sapolsky R, Ji X, Zhao H. Stroke. 2014
Sep;45(9):2769-76
Reduction in Overall Occurrences of Ischemic Events With Vorapaxar:
Results From TRACER. White HD, Huang Z, Tricoci P, Van de Werf F,
Wallentin L, Lokhnygina Y, Moliterno DJ, Aylward PE, Mahaffey KW,
Armstrong PW. J Am Heart Assoc. 2014 Jul 10;3(4)
Estimates of the continuously publishing core in the scientific
workforce. Ioannidis JP, Boyack KW, Klavans R. PLoS One. 2014 Jul
9;9(7):e101698
Repair of congenital heart disease with associated pulmonary hyper-
tension in children: what are the minimal investigative procedures?
Consensus statement from the Congenital Heart Disease and Pediatric
Task Forces, Pulmonary Vascular Research Institute (PVRI). Lopes AA,
Barst RJ, Haworth SG, Rabinovitch M, Al Dabbagh M, Del Cerro MJ, Ivy
D, Kashour T, Kumar K, Harikrishnan S, D’Alto M, Thomaz AM, Zorzanelli
L, Aiello VD, Mocumbi AO, Santana MV, Galal AN, Banjar H, Tamimi O,
Heath A, Flores PC, Diaz G, Sandoval J, Kothari S, Moledina S, Gon-
çalves RC, Barreto AC, Binotto MA, Maia M, Al Habshan F, Adatia I. Pulm
Circ. 2014 Jun;4(2):330-41
Erythropoietin upregulation in pulmonary arterial hypertension. Kara-
manian VA, Harhay M, Grant GR, Palevsky HI, Grizzle WE, Zamanian RT,
Ihida-Stansbury K, Taichman DB, Kawut SM, Jones PL. Pulm Circ. 2014
Jun;4(2):269-79
Perioperative pharmacological management of pulmonary hyperten-
sive crisis during congenital heart surgery. Brunner N, de Jesus Perez VA, Richter A, Haddad F, Denault A, Rojas V, Yuan K, Orcholski M, Liao
X. Pulm Circ. 2014 Mar;4(1):10-24.
A ‘green button’ for using aggregate patient data at the point of care.
Longhurst CA, Harrington RA, Shah NH. Health Aff (Millwood). 2014
Jul;33(7):1229-35
Alive and well? Exploring disease by studying lifespan. Brett JO, Rando TA. Curr Opin Genet Dev. 2014 Jul 5;26C:33-40
No misrepresentation of vital status follow-up in PLATO: Predefined
analyses guarantee the integrity of the benefits of ticagrelor over clop-
idogrel in the PLATO trial: Commentary on: DiNicolantonio JJ, Tomek
A, Misrepresentation of vital status follow-up: Challenging the integrity
of the PLATO trial and the claimed mortality benefit of ticagrelor ver-
sus clopidogrel, International Journal of Cardiology, 2013 Serebruany
VL. Discrepancies in the primary PLATO trial publication and the FDA
reviews, International Journal of Cardiology, 2014. Wallentin L, Becker
RC, Cannon CP, Held C, Himmelmann A, Husted S, James SK, Katus HA,
Mahaffey KM, Pieper KS, Storey RF, Steg PG, Harrington RA; PLATO
Investigators. Int J Cardiol. 2014 Sep;176(1):300-2
Tetralogy of Fallot: aorto-pulmonary collaterals and pulmonary arter-
ies have distinctly different transcriptomes. Ma X, Barboza LA, Siyahian
A, Reinhartz O, Maeda K, Reddy VM, Hanley FL, Riemer RK. Pediatr
Res. 2014 Jul 7
SCAI/AATS/ACC/STS operator and institutional requirements for trans-
catheter valve repair and replacement. Part II. Mitral valve. Tommaso
CL, Fullerton DA, Feldman T, Dean LS, Hijazi ZM, Horlick E, Weiner BH,
Zahn E, Cigarroa JE, Ruiz CE, Bavaria J, Mack MJ, Cameron DE, Bolman
RM 3rd, Miller DC, Moon MR, Mukherjee D, Trento A, Aldea GS, Bacha
EA. J Thorac Cardiovasc Surg. 2014 Aug;148(2):387-400
An algorithm to estimate the object support in truncated images. Hsieh
SS, Nett BE, Cao G, Pelc NJ. Med Phys. 2014 Jul;41(7):071908
Red blood cells serve as intravascular carriers of myeloperoxidase.
Adam M, Gajdova S, Kolarova H, Kubala L, Lau D, Geisler A, Ravekes
T, Rudolph V, Tsao PS, Blankenberg S, Baldus S, Klinke A. J Mol Cell
Cardiol. 2014 Sep;74:353-63
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AUGUST 91 Publications
Calculating risks and benefits to help guide revascularization deci-
sions: turning all available data into useful information. Harrington RA. J Am Coll Cardiol. 2014 Aug 5;64(5):433-5
Study of exonic variation identifies incremental information regarding
lipid-related and coronary heart disease genes. Assimes TL, Querter-mous T. Circ Res. 2014 Aug 15;115(5):478-80
Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Re-
capitulates Long QT Phenotype for Drug Testing. Wang Y, Liang P, Lan F,
Wu H, Lisowski L, Gu M, Hu S, Kay MA, Urnov FD, Shinnawi R, Gold JD,
Gepstein L, Wu JC. J Am Coll Cardiol. 2014 Aug 5;64(5):451-9
Effect of human donor cell source on differentiation and function of
cardiac induced pluripotent stem cells. Sanchez-Freire V, Lee AS, Hu S,
Abilez OJ, Liang P, Lan F, Huber BC, Ong SG, Hong WX, Huang M, Wu JC. J Am Coll Cardiol. 2014 Aug 5;64(5):436-48
Circulating tumor microemboli diagnostics for patients with non-
small-cell lung cancer. Carlsson A, Nair VS, Luttgen MS, Keu KV, Horng
G, Vasanawala M, Kolatkar A, Jamali M, Iagaru AH, Kuschner W, Loo BW
Jr, Shrager JB, Bethel K, Hoh CK, Bazhenova L, Nieva J, Kuhn P, Gamb-hir SS. J Thorac Oncol. 2014 Aug;9(8):1111-9
Effects of Transendocardial CD34+ Cell Transplantation in Patients
With Ischemic Cardiomyopathy. Poglajen G, Sever M, Cukjati M, Cernelc
P, Knezevic I, Zemljic G, Haddad F, Wu JC, Vrtovec B. Circ Cardiovasc
Interv. 2014 Aug;7(4):552-9
Clinical characteristics and outcomes with rivaroxaban vs. warfarin in
patients with non-valvular atrial fibrillation but underlying native mitral
and aortic valve disease participating in the ROCKET AF trial. Breithardt
G, Baumgartner H, Berkowitz SD, Hellkamp AS, Piccini JP, Stevens SR,
Lokhnygina Y, Patel MR, Halperin JL, Singer DE, Hankey GJ, Hacke W,
Becker RC, Nessel CC, Mahaffey KW, Fox KA, Califf RM; for the ROCKET
AF Steering Committee & Investigators. Eur Heart J. 2014 Aug 22
Usefulness and Safety of Vorapaxar in Patients With Non-ST-Segment
Elevation Acute Coronary Syndrome Undergoing Percutaneous Coro-
nary Intervention (from the TRACER Trial). Valgimigli M, Tricoci P,
Huang Z, Aylward PE, Armstrong PW, Van de Werf F, Leonardi S, White
HD, Widimsky P, Harrington RA, Cequier A, Chen E, Lokhnygina Y, Wal-
lentin L, Strony J, Mahaffey KW, Moliterno DJ. Am J Cardiol. 2014 Sep
1;114(5):665-73
A long noncoding RNA protects the heart from pathological hypertro-
phy. Han P, Li W, Lin CH, Yang J, Shang C, Nuernberg ST, Jin KK, Xu W,
Lin CY, Lin CJ, Xiong Y, Chien HC, Zhou B, Ashley E, Bernstein D, Chen
PS, Chen HS, Quertermous T, Chang CP. Nature. 2014 Aug 10
Increased Mortality Associated With Digoxin in Contemporary Patients
With Atrial Fibrillation: Findings From the TREAT-AF Study. Turakhia MP, Santangeli P, Winkelmayer WC, Xu X, Ullal AJ, Than CT, Schmitt S,
Holmes TH, Frayne SM, Phibbs CS, Yang F, Hoang DD, Ho PM, Heiden-reich PA. J Am Coll Cardiol. 2014 Aug 19;64(7):660-8
Simple, standardized incorporation of genetic risk into non-genetic
risk prediction tools for complex traits: coronary heart disease as an
example. Goldstein BA, Knowles JW, Salfati E, Ioannidis JP, Assimes TL. Front Genet. 2014 Aug 1;5:254
Stable, Covalent Attachment of Laminin to Microposts Improves the
Contractility of Mouse Neonatal Cardiomyocytes. Ribeiro AJ, Zaleta-
Rivera K, Ashley EA, Pruitt BL. ACS Appl Mater Interfaces. 2014 Aug 26
Association of lower extremity performance with cardiovascular
and all-cause mortality in patients with peripheral artery disease: a
systematic review and meta-analysis. Morris DR, Rodriguez AJ, Moxon
JV, Cunningham MA, McDermott MM, Myers J, Leeper NJ, Jones RE,
Golledge J. J Am Heart Assoc. 2014 Aug 13;3(4)
Tissue-engineered, hydrogel-based endothelial progenitor cell therapy
robustly revascularizes ischemic myocardium and preserves ventricu-
lar function. Atluri P, Miller JS, Emery RJ, Hung G, Trubelja A, Cohen
JE, Lloyd K, Han J, Gaffey AC, MacArthur JW, Chen CS, Woo YJ. J Thorac
Cardiovasc Surg. 2014 Sep;148(3):1090-8
Aldehyde dehydrogenase-2 regulates nociception in rodent models of
acute inflammatory pain. Zambelli VO, Gross ER, Chen CH, Gutierrez VP,
Cury Y, Mochly-Rosen D. Sci Transl Med. 2014 Aug 27;6(251):251ra118.
Association of the selected dimensions of eudaimonic well-being with
healthy survival to 85 years of age in older women. Zaslavsky O, Rilla-
mas-Sun E, Woods NF, Cochrane BB, Stefanick ML, Tindle H, Tinker LF,
LaCroix AZ. Int Psychogeriatr. 2014 Aug 27:1-11.
Optimizing real time fMRI neurofeedback for therapeutic discovery and
development. Stoeckel LE, Garrison KA, Ghosh S, Wighton P, Hanlon
CA, Gilman JM, Greer S, Turk-Browne NB, deBettencourt MT, Scheinost
D, Craddock C, Thompson T, Calderon V, Bauer CC, George M, Breiter
HC, Whitfield-Gabrieli S, Gabrieli JD, LaConte SM, Hirshberg L, Brewer
JA, Hampson M, Van Der Kouwe A, Mackey S, Evins AE. Neuroimage
Clin. 2014 Jul 10;5:245-255. eCollection 2014. Review.
Customized atomic force microscopy probe by focused-ion-beam-
assisted tip transfer. Wang A, Butte MJ. Appl Phys Lett. 2014 Aug
4;105(5):053101.
Noncontact, low-frequency ultrasound therapy enhances neovascu-
larization and wound healing in diabetic mice. Maan ZN, Januszyk
M, Rennert RC, Duscher D, Rodrigues M, Fujiwara T, Ho N, Whitmore
A, Hu MS, Longaker MT, Gurtner GC. Plast Reconstr Surg. 2014
Sep;134(3):402e-11e
RNA-guided endonuclease provides a therapeutic strategy to cure
latent herpesviridae infection. Wang J, Quake SR. Proc Natl Acad Sci
U S A. 2014 Aug 25
Statin-induced Diabetes: How Important is Insulin Resistance?
Abbasi F, Reaven GM. J Intern Med. 2014 Aug 22
Comparison of three ECG criteria for athlete pre-participation screen-
ing. Pickham D, Zarafshar S, Sani D, Kumar N, Froelicher V. J Electro-
cardiol. 2014 Aug 2
FA L L 2 0 1 4 | 17
Perspective for special Gurdon issue for differentiation: Can cell fusion
inform nuclear reprogramming? Burns D, Blau HM. Differentiation.
2014 Aug 20
An implantable microfluidic device for self-monitoring of intraocular
pressure. Araci IE, Su B, Quake SR, Mandel Y. Nat Med. 2014 Aug 24
A Registry-Based Randomized Trial Comparing Radial and Femoral Ap-
proaches in Women Undergoing Percutaneous Coronary Intervention:
The SAFE-PCI for Women (Study of Access Site for Enhancement of PCI
for Women) Trial. Rao SV, Hess CN, Barham B, Aberle LH, Anstrom KJ,
Patel TB, Jorgensen JP, Mazzaferri EL Jr, Jolly SS, Jacobs A, Newby LK,
Gibson CM, Kong DF, Mehran R, Waksman R, Gilchrist IC, McCourt BJ,
Messenger JC, Peterson ED, Harrington RA, Krucoff MW. JACC Cardio-
vasc Interv. 2014 Aug;7(8):857-67
Nanoscale nickel oxide/nickel heterostructures for active hydrogen
evolution electrocatalysis. Gong M, Zhou W, Tsai MC, Zhou J, Guan M,
Lin MC, Zhang B, Hu Y, Wang DY, Yang J, Pennycook SJ, Hwang BJ, Dai H. Nat Commun. 2014 Aug 22;5:4695.
Obesity, physical activity, and their interaction in incident atrial fibril-
lation in postmenopausal women. Azarbal F, Stefanick ML, Salmoi-
rago-Blotcher E, Manson JE, Albert CM, LaMonte MJ, Larson JC, Li W,
Martin LW, Nassir R, Garcia L, Assimes TL, Tharp KM, Hlatky MA, Perez MV. J Am Heart Assoc. 2014 Aug 20;3(4)
Influence of interfacial rheology on drainage from curved surfaces.
Bhamla MS, Giacomin CE, Balemans C, Fuller GG. Soft Matter. 2014 Aug
20;10(36):6917-25
Detection of Osseous Metastasis by 18F-NaF/18F-FDG PET/CT Versus CT
Alone. Sampath SC, Sampath SC, Mosci C, Lutz AM, Willmann JK, Mittra
ES, Gambhir SS, Iagaru A. Clin Nucl Med. 2014 Aug 19
Relationship Among 25-Hydroxyvitamin D Concentrations, Insulin
Action, and Cardiovascular Disease Risk in Patients With Essential
Hypertension. Abbasi F, Feldman D, Caulfield MP, Hantash FM, Reaven GM. Am J Hypertens. 2014 Aug 19
A quantitative comparison of single-cell whole genome amplification
methods. de Bourcy CF, De Vlaminck I, Kanbar JN, Wang J, Gawad C,
Quake SR. PLoS One. 2014 Aug 19;9(8):e105585
Are preoperative B-type natriuretic peptide levels associated with
outcome after pulmonary artery banding and the double switch opera-
tion in patients with congenitally corrected transposition of the great
arteries: A pilot study. Char DS, Shiboski SC, Hanley FL, Fineman JR. J
Thorac Cardiovasc Surg. 2014 Jul 24
Medicine. Letting go of mucus. Wine JJ. Science. 2014 Aug
15;345(6198):730-1
Patients’ Perspectives on Hemodialysis Vascular Access: A Systematic
Review of Qualitative Studies. Casey JR, Hanson CS, Winkelmayer WC,
Craig JC, Palmer S, Strippoli GF, Tong A. Am J Kidney Dis. 2014 Aug 9
Postoperative ICU Management of Vascular Surgery Patients. Crimi E,
Hill CC. Anesthesiol Clin. 2014 Sep;32(3):735-757
Considerations for Patients Undergoing Endovascular Abdominal
Aortic Aneurysm Repair. Ullery BW, Lee JT. Anesthesiol Clin. 2014
Sep;32(3):723-734
Thrombin Cleavage of Osteopontin Disrupts a Pro-chemotactic Se-
quence for Dendritic Cells, which is Compensated by the Release of its
Pro-chemotactic C-Terminal Fragment. Shao Z, Morser J, Leung LL. J
Biol Chem. 2014 Aug 11
The association between biventricular pacing and cardiac resynchroni-
zation therapy-defibrillator efficacy when compared with implantable
cardioverter defibrillator on outcomes and reverse remodelling. Ru-
wald AC, Kutyifa V, Ruwald MH, Solomon S, Daubert JP, Jons C, Brenyo
A, McNitt S, Do D, Tanabe K, Al-Ahmad A, Wang P, Moss AJ, Zareba W.
Eur Heart J. 2014 Aug 11
Transposition of the Left Renal Vein for the Treatment of Nutcracker
Syndrome in Children: A Short-term Experience. Ullery BW, Itoga NK,
Mell MW. Ann Vasc Surg. 2014 Aug 8
Protein-Engineered Hydrogel Encapsulation for 3-D Culture of Murine
Cochlea. Chang DT, Chai R, DiMarco R, Heilshorn SC, Cheng AG. Otol
Neurotol. 2014 Aug 8.
Hybrid Elastin-like Polypeptide-Polyethylene Glycol (ELP-PEG) Hydro-
gels with Improved Transparency and Independent Control of Matrix
Mechanics and Cell Ligand Density. Wang H, Cai L, Paul A, Enejder A,
Heilshorn SC. Biomacromolecules. 2014 Aug 20.
The proteome of cholesteryl-ester-enriched versus triacylglycerol-
enriched lipid droplets. Khor VK, Ahrends R, Lin Y, Shen WJ, Adams CM,
Roseman AN, Cortez Y, Teruel MN, Azhar S, Kraemer FB. PLoS One.
2014 Aug 11;9(8):e105047
The International Society of Heart and Lung Transplantation Guidelines
for the management of pediatric heart failure: Executive summary.
Kirk R, Dipchand AI, Rosenthal DN, Addonizio L, Burch M, Chrisant M,
Dubin A, Everitt M, Gajarski R, Mertens L, Miyamoto S, Morales D, Pahl
E, Shaddy R, Towbin J, Weintraub R. J Heart Lung Transplant. 2014
Sep;33(9):888-909.
Effect of treatment delay, age, and stroke severity on the effects of
intravenous thrombolysis with alteplase for acute ischaemic stroke:
a meta-analysis of individual patient data from randomised trials.
Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, Brott T,
Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von
Kummer R, Lansberg M, Lindley RI, Murray G, Olivot JM, Parsons M, Til-
ley B, Toni D, Toyoda K, Wahlgren N, Wardlaw J, Whiteley W, Del Zoppo
GJ, Baigent C, Sandercock P, Hacke W; for the Stroke Thrombolysis
Trialists’ Collaborative Group. Lancet. 2014 Aug 5
Temporal trends in mortality after coronary artery revascularization
in patients with end-stage renal disease. Krishnaswami A, Leong TK,
Hlatky MA, Chang TI, Go AS. Perm J. 2014 Summer;18(3):11-6
Translational strategies and challenges in regenerative medicine.
Dimmeler S, Ding S, Rando TA, Trounson A. Nat Med. 2014 Aug
6;20(8):814-21
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The Stanford Medical Youth Science Program: educational and science-
related outcomes. Crump C, Ned J, Winkleby MA. Adv Health Sci Educ
Theory Pract. 2014 Aug 6
Temporal Trends in Patient Characteristics and Outcomes Among
Medicare Beneficiaries Undergoing Primary Prevention Implantable
Cardioverter-Defibrillator Placement in the United States, 2006-2010:
Results from the NCDR® ICD Registry. Borne RT, Peterson PN, Greenlee
R, Heidenreich PA, Wang Y, Curtis JP, Tzou WS, Varosy PD, Kremers MS,
Masoudi FA. Circulation. 2014 Aug 5
Acute kidney injury in the pediatric cardiac patient. Axelrod DM,
Sutherland SM. Paediatr Anaesth. 2014 Sep;24(9):899-901
Adherence to postoperative surveillance guidelines after endovascular
aortic aneurysm repair among Medicare beneficiaries. Garg T, Baker LC, Mell MW. J Vasc Surg. 2014 Jul 31
A novel, catheter-based approach to left ventricular assist device
deactivation after myocardial recovery. Zeigler SM, Sheikh AY, Lee PH,
Desai J, Banerjee D, Oyer P, Dake MD, Ha RV. Ann Thorac Surg. 2014
Aug;98(2):710-3
Nanoscale high-content analysis using compositional heterogeneities
of single proteoliposomes. Mathiasen S, Christensen SM, Fung JJ, Ras-
mussen SG, Fay JF, Jorgensen SK, Veshaguri S, Farrens DL, Kiskowski M,
Kobilka B, Stamou D. Nat Methods. 2014 Sep;11(9):931-4
TEMPORARY REMOVAL: A consensus document for the selection of lung
transplant candidates: 2014-An update from the Pulmonary Trans-
plantation Council of the International Society for Heart and Lung
Transplantation. Weill D, Benden C, Corris PA, Dark JH, Duane Davis R,
Keshavjee S, Lederer DJ, Mulligan MJ, Alexander Patterson G, Singer LG,
Snell GI, Verleden GM, Zamora MR, Glanville AR. J Heart Lung Trans-
plant. 2014 Jun 26
Pumping it up! Angiogenesis and muscle deconditioning in pulmonary
hypertension. de Jesus Perez VA. Am J Respir Crit Care Med. 2014 Aug
1;190(3):250-1
H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Con-
sistency. Benayoun BA, Pollina EA, Ucar D, Mahmoudi S, Karra K, Wong
ED, Devarajan K, Daugherty AC, Kundaje AB, Mancini E, Hitz BC, Gupta
R, Rando TA, Baker JC, Snyder MP, Cherry JM, Brunet A. Cell. 2014 Jul
31;158(3):673-88
Genetic variant in folate homeostasis associated with lower warfa-
rin dose in African Americans. Daneshjou R, Gamazon ER, Burkley B,
Cavallari LH, Johnson JA, Klein TE, Limdi N, Hillenmeyer S, Percha B,
Karczewski KJ, Langaee T, Patel SR, Bustamante CD, Altman RB, Perera
MA. Blood. 2014 Jul 30
For the complete list of publications (June-August) visit: http://cvi.stanford.edu/research/memberpubs.html
265 Campus Drive, Stanford, CA 94305 http://cvi.stanford.edu
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FA L L 2 0 1 4 | 19
Tom Quertermous
Alan Yeung
Ronald Dalman
Y. Joseph Woo
Dominik Fleischmann
Robert Harrington
Joseph C. Wu, MD, PhDDirector, Stanford Cardiovascular Institute Professor, Dept. of Medicine (Cardiovascular) and Radiology
Joseph Wu
Kenneth Mahaffey
Stephen Roth
Mark Nicolls
Michael Snyder
Robert A. Harrington, MDArthur L. Bloomfield Professor of Medicine
Chair, Dept. of Medicine
Marlene Rabinovitch
Paul Yock
Ronald L. Dalman, MDWalter C. and Elsa R. Chidester Professor of SurgeryChief, Division of Vascular SurgeryDominik Fleischmann, MDProfessor, Dept. of RadiologyChief, Cardiovascular ImagingKenneth Mahaffey, MDProfessor, Dept. of MedicineVice Chair of Medicine for Clinical ResearchMark Nicolls, MDAssociate Professor, Dept. of MedicineChief, Pulmonary and Critical Care MedicineTom Quertermous, MDWilliam G. Irwin Professor of MedicineCo-Chief (Research), Division of Cardiovas-cular MedicineMarlene Rabinovitch, MDDwight and Vera Dunlevie Professor inPediatric Cardiology
Stephen J. Roth MD, MPHProfessor and Chief, Pediatric CardiologyDirector, Children’s Heart Center
Michael Snyder, PhDProfessor and Chair, Dept. of GeneticsDirector, Stanford Center for Genomics and Personalized MedicineY. Joseph Woo, MDNorman E. Shumway Professor in Cardio-thoracic SurgeryChair Dept. of Cardiothoracic Surgery
Alan Yeung, MDLi Ka Shing Professor of MedicineCo-Chief (Clinical), Division of Cardiovascu-lar Medicine
Paul Yock, MDMartha Meier Weiland Professor of Bioen-gineering and Medicine; and Professor, by courtesy, of Mechanical EngineeringDirector of Biodesign
Cardiovascular InstituteLeadership
FA L L 2 0 1 4 | 20
Stanford Cardiovascular Institute Annual RetreatDecember 2, 2014 | Paul Berg Hall, LKSC
The Future of Cardiovascular
Medicine
Keynote Speaker: Douglas L. Mann, MDChief, Cardiovascular Division Washington University School of Medicine REGISTER: http://goo.gl/yoH7bP
CVI supports art and medicine by Ryoko Hamaguchi