Curriculum Vitae

Personal Data Name in full : Shinichi Matsumoto

Sex : Male Date of Birth : March 17, 1963 Place of Birth : Osaka Japan

Present Address: 1510 Park Chase Ave Arlington TX 76011-2741 Marital Status : Married

Eriko Matsumoto, Wife (BOD: June 17, 1965) Kyohei Matsumoto, Son (BOD: October 13, 1992) Hana Rebecca Matsumoto, Daughter (BOD: September 11, 1999)

Position Title: Director, All Saints Islet Cell Laboratory,

Director, Islet Cell Transplantation Laboratory Baylor Institute of Immunology Research Adjunct Professor, Department of Biomedical Sciences, University of North

Texas HSC

Education Kobe University, Kobe, Japan: MD: 1988: Medicine

Kobe University Graduate School, Kobe, Japan: PhD: 1996: Surgery

Medical Licensure: Japan 313421(May 20, 1988) State of Washington Physician Limited Licensure (January 1, 2001)

(Number 025214 TR00039561)

Specialty Board Certification: Japanese Board of Surgical Society (1993/7) Japanese Board of Gastroenterological Surgery (1995/7)

Postgraduate training

1988-1992, Kobe University Hospital and affiliated hospitals, Kobe and Osaka Japan Academic appointments

1992-1996: Postgraduate School, Kobe University School of Medicine, Kobe Japan 1996-1997: Medical Staff, Kobe University Hospital, Kobe, Japan

1997-1999: Senior Research Fellow, Department of Surgery, University of Minnesota 1999-2000: Visiting Scientist, Department of Surgery, University of Washington 1999-2000: Research Fellow, Puget Sound Blood Center and Program

2000-2002: Senior Research Scientist in Human Islet Transplantation and Consultant to the Human Islet Processing Facility, Northwest Tissue Center

Chief Research Scientist at Islet and Cell Processing Laboratory (Northwest Tissue Center) 2000-2002: Research Associate, Department of Surgery, University of Washington 2001-2002: Consultant, University of Washington Medical Center Transplant Surgery

2002-2006: Assistant Professor Kyoto University Hospital Transplantation Unit 2005-2006: Lecturer Kyoto University Graduate School of Pharmacology

2005-2006: Director, Diabetes Research Institute, Kyoto 2006-2006: Professor, Second Department of Surgery, Fujita Health University, Aichi 2006-2006: Director, Diabetes Research Institute Japan

2006-present: Visiting Professor, Universidad Alas Peruanas, Peru 2006-present: Visiting Professor, Medical Information and System Research Center, Teikyo

University School of Medicine

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2007-present: Director, Baylor All Saints Islet Laboratory 2007-present: Director, Islet Cell Transplantation Laboratory, Baylor Institute of Immunology

Research (BIIR) 2007-present: Visiting Professor, Fujita Health University, Aichi

2008-present: Visiting Scientist, The Institute of Medical Science, the University of Tokyo 2009-present: Adjunct Professor, the Department of Biomedical Sciences at University of North Texas HSC

Honors

Travelers Grant: The 100th Annual Congress of Japan Surgical Society. April 2000 12-14 Tokyo Japan

Imura Clinical Research Award 2005 December 12th

Healthcare Hero 2009 (Fort Worth Business Press) February 19th 2009

Chair of International Congress

1. 8th International Congress of International Pancreas and Islet Transplant Association:

CLINICAL PANCREAS TRANSPLANTATION, June 2001, Innsbruck Austria. 2. 10th International Congress of International Pancreas and Islet Transplant Association:

CLINICAL ISLET TRANSPLANTATION, May 2005, Geneva Switzerland.

3. American Transplant Congress: Morning Seminar ISLET TRANSPLANTATION May 2005, Seattle USA

4. 8th Immunology for Diabetes Society: An overview with a discussion following: how close are we to overcoming the obstacles limiting transplant-based treatment approaches for diabetes?

-In Memory of Dr. Paul Lacy- October 9th 2005, Hyogo Japan 5. 11th International Congress of International Pancreas and Islet Transplantation Association:

AABB-Early Bird Workshop- Regulations, Standards and the Accreditation Process for the Islet Cell Laboratory. September 20th 2007 Minneapolis USA

6. American Transplant Congress: parallel session; Islet, stem cell, cell transplantation, May 4 th 2010, San Diego CA

Members

American Society of Transplantation The Transplantation Society International Pancreas and Islet Transplantation Society

The Japan Society for Transplantation

Japanese Society of Tissue Transplantation Japan Diabetes Society Japan Surgical Society

Japanese Society of Gastroenterological Surgery Member of Evidenced-based Practice Guideline for the Treatment of Diabetes in Japan

(The Japan Diabetes Society) Baylor Regional Transplant Institute: Advisory Board Journal of Diabetes: Editorial Board

Sernova Corp: Scientific Advisor

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Publications

English

1. Kuroda Y, Tanioka Y, Morita A, Hiraoka K, Matsumoto S, Fujino Y, Ku Y, Saitoh Y, Sugihara J, Okumura S, Hori K. The possibility of restoration of human pancreas

function during preservation by the two-layer (University of Wisconsin solution/perfluorochemical) method following normothermic ischemia. Transplantation 57, 282-285, 1994

2. Kuroda Y, Tanioka Y, Morita A, Hiraoka K, Matsumoto S, Fujino Y, Yamamoto M,

Ku Y, Saitoh Y. Protective effect of preservation of canine pancreas by the two-layer (University of Wisconsin solution/perfluorochemical) method against rewarming ischemic injury during implantation. Transplantation 57, 658-661, 1994

3. Kuroda Y, Hiraoka K, Tanioka Y, Matsumoto S, Morita A, Fujino Y, Suzuki Y, Ku

Y, Saitoh Y. Role of adenosine in preservation by the two-layer method of ischemically damaged pancreas. Transplantation 57, 1017-1020, 1994

4. Hiraoka K, Kuroda Y, Tanioka Y, Matsumoto S, Fujino Y, Morita A, Ku Y, Saitoh Y. Adenosine is a key component in preservation of ischemically damaged canine

pancreas by the two-layer cold storage method. Transplantation proceedings 26, 953-955, 1994

5. Kuroda Y, Hiraoka K, Tanioka Y, Matsumoto S, Fujino Y, Morita A, Suzuki Y, Ku Y, Saitoh Y. Metabolic intervention to affect canine pancreas recovery following

ischemia during preservation by the two-layer method. Transplantation International 7, 436-440, 1994

6. Kuroda Y, Tanioka Y, Matsumoto S, Suzuki Y, Ku Y, Saitoh Y. Difference in energy metabolism between fresh and warm ischemic canine pancreas during

preservation by the two-layer method. Transplantation International 7, 441-445, 1994

7. Hiraoka K, Kuroda Y, Tanioka Y, Matsumoto S, Kim Y, Sakai T, Fujita H, Hamano M, Suzuki Y, Ku Y, Saitoh Y. The importance of adenosine and a colloid (dextran

40) in resuscitation of ischemically damaged canine pancreas during preservation by the two-layer method. Transplantation 58, 1279-1281, 1994

8. Kuroda Y, Tanioka Y, Morita A, Hiraoka K, Matsumoto S, Fujino Y, Ku Y, Saitoh Y, Sugihara J, Okumura S, Hori K. The possibility of resuscitation of ischemically

damaged human pancreas during preservation by the two-layer (UW solution/perfluorochemical) method. Proceedings of International Gastrosurgical Club, 792-795, 1994

9. Kuroda Y, Tanioka Y, Fujino Y, Morita A, Hiraoka K, Matsumoto S, Suzuki Y, Ku

Y, Saitoh Y, Sugihara J, Okumura S, Hori K. The possibility of clinical application of the two-layer (UW solution/perfluorochemical) method for human pancreas preservation. Proceedings of International Gastrosurgical Club, 799-800, 1994

10. Kuroda Y, Kawamura T, Tanioka Y, Morita A, Hiraoka K, Matsumoto S, Kim Y,

Fujino Y, Suzuki Y, Ku Y, Saitoh Y. Heart preservation using a cavitary two-layer (University of Wisconsin solution/perfluorochemical) cold storage method. Transplantation 59, 699-701, 1995

11. Kuroda Y, Tanioka Y, Matsumoto S, Kim Y, Fujita H, Ajiki T, Suzuki Y, Ku Y,

Saitoh Y. A new technique for pancreaticogastrointestinal anastomosis without

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suturing the pancreatic parenchyma. Journal of American college of Surgeons 181, 311-314, 1995

12. Kuroda Y, Matsumoto S, Fujita H, Tanioka Y, Sakai T, Hamano M, Hiraoka K, Kim

Y, Suzuki Y, Ku Y, Saitoh Y. Resuscitation of ischemically damaged pancreas during short-term preservation at 20°C by the two-layer (University of Wisconsin solution/perfluorochemical) method. Transplantation 61, 28-30, 1996

13. Kuroda Y, Sakai T, Suzuki Y, Tanioka Y, Matsumoto S, Kim Y, Fujita H, Hamano

M, Hasegawa Y, Ku Y, Saitoh Y. Small bowel preservation using a cavitary two-layer (University of Wisconsin solution/perfluorochemical) cold storage method. Transplantation 61, 370-373, 1996

14. Matsumoto S, Kuroda Y, Fujita H, Tanioka Y, Sakai T, Hamano M, Kim Y, Suzuki

Y, Ku Y, Saitoh Y. Extending the margin of safety of preservation period for resuscitation of ischemically damaged pancreas during preservation using the two-layer (University of Wisconsin solution/perfluorochemical) method at 20°C with

thromboxane A2 synthesis inhibitor OKY046. Transplantation 61, 879-883, 1996

15. Kuroda Y, Suzuki Y, Ku Y, Ajiki T, Tanioka Y, Matsumoto S, Saitoh Y. Biliary-enteric anastomosis using a single layer of serosubmucosal sutures without a T-tube drainage. Archives of Surgery, 131, 637-640, 1996

16. Matsumoto S, Kuroda Y, Fujita H, Tanioka Y, Kim Y, Sakai T, Hamano M, Suzuki

Y, Ku Y, Saitoh Y. Resuscitation of ischemically damaged pancreas by the two-layer (University of Wisconsin solution/perfluorochemical) mild hypothermic storage method. World Journal of Surgery, 20 1030-1033, 1996

17. Suzuki Y, Kuroda Y, Tanioka Y, Matsumoto S, Kim Y, Fujita H, Sakai T, Hamano

M, Ku Y, Saitoh Y. New technique of orthotopic segmental pancreas transplantation with portal venous drainage established by interposing the splenic vessels. Transplant proc, 28 1804-1806, 1996

18. Kuroda Y, Suzuki Y, Ku Y, Matsumoto S, Morita A, Tanioka Y, Kim Y, Fujita H,

Sakai T, Hamano M, Hiraoka K, Saitoh Y. Possibility of pancreas transplantation from non-heart beating cadaver donors. Transplant proc, 28 1876-1877, 1996

19. Sakai T, Kuroda Y, Suzuki Y, Kim Y, Matsumoto S, Y.Hasegawa, Saitoh Y. Adenosine nucleotide metabolism of the small bowel during preservation by the

cavitary two-layer method. Transplant proc, 28 2614-2618, 1996

20. Matsumoto S, Kuroda Y, Saitoh Y. The effect of preservation temperature and

period on resuscitation of the ischemically damaged canine pancreas during preservation by the two-layer (University of Wisconsin solution/perfluorochemical)

method. Kobe Journal of Medical Sciences, 42, 1-17, 1996

21. Matsumoto S, Kuroda Y, Hamano M, Kim Y, Suzuki Y, Ku Y, Saitoh Y. Direct

evidence of pancreatic tissue oxygenation during preservation by the two-layer method. Transplantation, 62, 1667-1670, 1996

22. Tanioka Y. Kuroda Y, Kim Y, Matsumoto S, Suzuki Y, Ku Y, Fujita H, Saitoh Y.

The effect of ouabain (inhibitor of an ATP-dependent Na+/K+ pump) on the

pancreas graft during preservation by the two-layer method.. Transplantation, 62, 1730-1734, 1996

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23. Kim Y, Kuroda Y, Tanioka Y, Matsumoto S, Fujita H, Sakai T, Hamano M, Suzuki Y, Ku Y, Saitoh Y. Recovery of adenosine triphosphate tissue levels of grafts

preserved by the two-layer method after reperfusion. Artificial Organs 20, 1120-1124, 1996

24. Kim Y, Kuroda Y, Tanioka Y, Matsumoto S, Fujita H, Sakai T, Hamano M, Suzuki

Y, Ku Y, Saitoh Y. Recovery of pancreatic tissue perfusion and ATP tissue level

after reperfusion in canine pancreas grafts preserved by the two-layer method. Pancreas 14, 285-289, 1997

25. Matsumoto S, Kuroda Y, Suzuki Y, Ku Y, Fujita H, Saitoh Y. Thromboxane A2

synthesis inhibitor OKY046 ameliorates vascular endothelial injury of pancreas graft

during preservation by the two-layer UW solution/perfluorochemical method at 20°C. Transplant proc 29, 1359-1362, 1997

26. Kuroda Y, Fujita H, Matsumoto S, Suzuki Y, Kim Y, Tanioka Y, Ku Y. Protection

of canine pancreatic microvascular endothelium against cold ischemic injury during

preservation by the two-layer method. Transplantation 64, 948-953, 1997

27. Suzuki Y, Kuroda Y, Tanioka Y, Matsumoto S, Kim Y, Ku Y, Tsukamoto R, Saitoh Y. Peripancreatic fluid cytology: detection of early rejection versus graft pancreatitis after canine pancreatic transplantation. World J Surg, 21, 880-4, 1997

28. Suzuki Y, Kuroda Y, Tanioka Y, Matsumoto S, Kim Y, Fujita H, Sakai T, Hamano

M, Ku Y. Beneficial effect of splenic vessel interposition on thrombosis prevention in canine orthotopic segmental pancreas transplantation. Transplant Proc 30, 145-146, 1998

29. Matsumoto S, Zhang HJ, Gilmore T, Van der Burg MP, Sutherland DER, Hering BJ.

Large-scale isopycnic islet purification utilizing non-toxic, endotoixn-free media facilitates immediate single-donor pig islet allograft function. Transplantation 66, S30, 1998

30. Matsumoto S, Shibata S, Kirchhof N, Hiraoka K, Sageshima J, Zhang X, Gilmore T,

Ansite J, Zhang H, Sutherland DER, Hering BJ. Immediate reversal of diabetes in primates following intraportal transplantation of porcine islets purified on a new histidine- lactobionate-iodixanol gradient. Transplantation 67, S220, 1999

31. Matsumoto S, Fujino Y, Suzuki Y, Tanioka Y, Muramatsu S, Sugimoto T, Ku Y,

Yasunami Y, Kuroda Y. Evidence of protein synthesis during resuscitation of ischemically damaged canine pancreas by the two-layer method. Pancreas 20, 411-414, 2000

32. Matsumoto S, Kandaswamy R, Sutherland DER, Hassoun A, Hiraoka K, Sageshima

J, Shibata S, Tanioka Y, Kuroda Y. Clinical application of the two-layer [University of Wisconsin solution (UW)/perfluorochemical (PFC) plus O2] method of pancreas preservation before transplantation. Transplantation 70, 771-774, 2000

33. Matsumoto S, Lawrence O, Rigley T, Lakey JRT, Stevens RB, Strong DM.

University of Wisconsin solution with trypsin inhibitor Pefabloc improves survival of viable human and primate impure islets during storage. Cell and Tissue Banking 2, 15-21, 2001

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34. An islet transplantation a realistic therapy for the treatment of type I diabetes in the near future? Stevens RB, Matsumoto S, Marsh CL. Clinical Diabetes 19, 51-60,

2001

35. Shibata S, Matsumoto S, Sageshima J, Hiraoka K, Sutherland DER, Kirchhof N, Guo Z, Koyama K, Gilmore TR, Dunning M, Ansite JD, Shearer JD, Clemmings S, Hedlund BE, Sehgal SN, Hering BJ. Temporary treatment with sirolimus and low-

trough cyclosporine prevents acute islet allograft rejection, and combination with starch-conjugated deferoxamine promotes islet engraftment in the preclinical pig

model. Transplant Proc 33, 509, 2001

36. Shibata S, Kirchhof N, Matsumoto S, Sageshima J, Hiraoka K, Ansite J, Wijkstrom

M, Sutherland DER, Hering BJ. High-dose streptozotocin for diabetes induction in adult rhesus monkeys. Transplant Proc 34, 1341-1344, 2002

37. Hiraoka K, Kuroda Y, Suzuki Y, Fujino Y, Tanioka Y, Matsumoto S, Sakai T,

Kandaswamy R, Sutherland DER. Outcomes in clinical pancreas transplantation

with the two-layer cold storage method versus simple storage in University of Wisconsin solution. Transplant Proc 34, 2688-2689, 2002

38. Sweet I, Cook DL, Wiseman RW, Greenbaum CJ, Lernmark A, Matsumoto S,

Teague JC, Krohn KA. Dynamic perifusion to maintain and assess isolated

pancreatic islets. Diabetes Technol Ther 4, 67-76, 2002

39. Matsumoto S, Stevens RB, Strong DM. Pancreatic islet cell processing for transplantation. Advances in Tissue Banking 6, 267-281, 2002

40. Matsumoto S, Rigley T, Qualley S, Kuroda Y, Reems J, Stevens RB. Efficacy of the oxygen-charged static two-layer method for short-term pancreas preservation and

islet isolation from nonhuman primate and human pancreata. Cell Transplant 11, 769-77, 2002

41. Matsumoto S, Qualley S, Goel S, Hagman D, Sweet I, Poitout V, Strong DM, Robertson RP, Reems J. Effect of the two-layer (University of Wisconsin solution-

perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation Protocol. Transplantation 74, 1414-1419, 2002

42. Matsumoto S, Kuroda Y. Perfluorocarbon for organ preservation before

transplantation. Transplantation 1804-1809, 74, 2002

43. Matsumoto S, Rigley T, Reems J, Kuroda Y, Stevens RB. Improved islet yields from

macaca nemestrina and marginal human pancreata after two-layer method preservation and endogenous trypsin inhibition. Am J Transplant 3, 53-63, 2003

44. Matsumoto S, Goel S, Qualley S, Strong DM, Reems J. A comparative evaluation of

culture media for the short-term maintenance (<24hr) of human islets isolated using

the Edmonton isolation protocol. Cell and Tissue Banking 4, 85-93, 2003

45. Noguchi H, Okitsu T, Tanaka K, Matsumoto S, Matsushita M, et al. A Novel Cell-permeable peptide allows successful allogenic islet transplantation in mice. Nature Medicine 10, 305-309, 2004

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46. Zhang G, Matsumoto S, Hyon SH, Qualley S, Reems J. Polyphenol, an extract of green tea, increases culture recovery rates of islets isolated from non-human primate

pancreata and marginal grade human pancreata. Cell Transplant 13: 145-152, 2004

47. Matsumoto S, Tanaka K, Strong DM, Jo Anna R. Efficacy of human islet isolation from the tail section of pancreas for the possibility of living donor islet transplantation. Transplantation 78: 839-843, 2004

48. Matsumoto S, Zhang G, Qualley S, et al. Analysis of donor factors affecting human

islet isolation with current isolation protocol. Transplant Proc 36: 1034-1036, 2004

49. Matsumoto S, Zhang G, Qualley S, et al. The effect of the two-layer (University of

Wisconsin solution/Perfluorochemical) method on clinical grade pancreata prior to islet isolation and transplantation. Transplant Proc 36: 1037-1039, 2004

50. Narushima M, Okitsu T, Miki A, Matsumoto S, et al. Adenovirus mediated gene

transduction of primarily isolated mouse islets. ASAIO J 50: 586-590, 2004

51. Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Yamada

Y, Fukuda K, Tsukiyama K, Suzuki H, Kawasaki Y, Shimodaira M, Matsuoka K, Shibata T, Kasai Y, Maekawa T, Shapiro J, Tanaka K. Insulin independence after living-donor distal pancreatectomy and islet allotransplantation. Lancet 365: 1642-

1644, 2005

52. Matsumoto S, Tanaka K. Pancreatic islet cell transplantation using non-heart-beating-donors (NHBDs). J of Hepato-Biliary-Pancreatic Surgery 12: 227-230, 2005

53. Matsumoto S. Clinical application of perfluorocarbons for organ preservation.

Artificial Cells, Blood Substitutes, and Biotechnology 33: 75-78, 2005

54. Matsumoto S, Iwanaga Y, Okitsu T, et al. Analysis large scale nonhuman primate

islet isolation Transplant Proc 37:1317-1321, 2005

55. Noguchi H, Susan Bonner Weir, Wei FY, Matsushita M, Matsumoto S. BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes 54: 2859-2866, 2005

56. Noguchi H, Nakai Y, Matsumoto S et al. Cell permeable peptide JNK inhibitor

prevents islet apoptosis immediately after isolation and improves islet graft function. Am J Transplant 5: 1848-1855, 2005

57. Noguchi H, Matsushita M, Matsumoto S et al. Mechanism of PDX-1 protein transduction. Biochem Biophys Res Comm 332: 68-74, 2005

58. Matsumoto S, Okitsu T, Iwanaga H, et al. Insulin independence of unstable diabetic

patient after single living donor islet transplantation. Transplant Proc 37: 3427-3429, 2005

59. Matsumoto S, Yamada Y, Okitsu T, et al. Simple evaluation of engraftment by

secretory unit of islet transplant objects (SUITO) for living donor and cadaveric

donor fresh or cultured islet transplantation. Transplant Proc 37: 3435-3437, 2005

60. Okitsu T, Matsumoto S, Iwanaga Y, et al. Kyoto islet isolation method – the

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optimized one for non-heart-beating donors with highly efficient islet retrieval. Transplant Proc 37: 3391-3392, 2005

61. Nagata H, Matsumoto S, Okitsu T, et al. In situ cooling of pancreata from non-heart-

beating-donors prior to procurement for islet transplantation. Transplant Proc 2005; 37: 3393-3395, 2005

62. Saito T, Ise K, Sato Y, Gotoh M, Matsumoto S et al. The start of an islet transplantation program in Japan. Transplant Proc 37: 3424-3426, 2005

63. Yonekawa Y, Matsumoto S, Okitsu T, et al. Effective islet isolation method with

extremely high islet yields from adult pigs. Cell Transplant 14: 575-562, 2005

64. Noguchi H, Matsumoto S, Okitsu T, et al. PDX-1 protein is internalized by lipid raft

– dependent macropinocytosis. Cell Transplant 14, 637-645, 2005

65. Matsumoto S, Noguchi H, Yonekawa Y, Okitsu T, Iwanaga Y, Liu X, Nagata H,

Kobayashi N, Ricordi C. Pancreatic islet transplantation for treating diabetes. Expert Opinion on Biological Therapy 6: 23-37, 2006

66. Noguchi H, Ueda M, Nakai Y, Iwanaga Y, Okitsu T, Nagata H, Yonekawa Y,

Kobayashi N, Nakamura T, Wada H, Matsumoto S. Modified two-layer

preservation method (M-Kyoto/PFC) improves islet yields in islet isolation. Am J Transplant 6, 496-504, 2006

67. Noguchi H, Matsumoto S. Protein transduction technology: A novel therapeutic

perspective. Acta Medica Okayama 60: 1-11, 2006

68. Miki A, Narushima M, Okitsu T, Takeno Y, Soto-Gutierrez, A, Rivas-Carrillo J

David, Navarro-Alvarez N, Chen Y, Tanaka K, Noguchi H, Matsumoto S, Kohara M, Lakey JRT, Kobayashi E, Tanaka N, Kobayashi N.. Maintenance of Mouse, Rat, and Pig Pancreatic Islet Functions by Coculture With Human Islet-Derived

Fibroblasts. Cell Transplantation 15, 325-334, 2006

69. Noguchi H, Matsumoto S, Matsushita M, et al. Immunosuppression for islet transplantation. Acta Medica Okayama 60, 71-76, 2006

70. Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Yamada Y, Fukuda K, Shibata T, Kasai Y, Maekawa T, Wada H, Nakamura T, Tanaka K.

Successful islet transplantation from non-heart-beating donor pancreata using modified Ricordi islet isolation method. Transplantation 82, 460-465, 2006

71. Nagata H, Matsumoto S, Okitsu T, et al. Procurement of the human pancreas for pancreatic islet transplantation from marginal cadaver donors. Transplantation 82,

327-331, 2006

72. Noguchi H, Matsumoto S. Protein transduction technology offers a novel therapeutic

approach for diabetes. J Hepatobiliary Pancreat Surg 13, 306-313, 2006

73. Sassa M, Fukuda K, Fujimoto S, Toyoda K, Fujita Y, Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Ohara T, Okamoto M, Tanaka K, Seino Y, Inagaki N, Yamada Y.A single transplantation of the islets can cause

glycemic stability and reduction of basal insulin requirement. Diabetes Research and Clinical Practice 73, 235-240, 2006

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74. Guangming Z, Matsumoto S, Newman H, Wang W, Strong DM, Robertson RP, Reems JA. Improved islet yield and quality from clinical grade pancreata preserved

by the two-layer method. Cell and Tissue Banking 7, 195-201, 2006

75. Ikeda H, Kobayashi N, Matsumoto S, et al. A newly developed bioartificial pancreas successfully controls blood glucose in totally pancreatectomized diabetic pigs. Tissue Engineering 12, 1799-1806, 2006

76. Yonekawa Y, Okitsu T, Wake K, Iwanaga Y, Noguchi H, Nagata H, Liu X,

Kobayashi N, Matsumoto S. A new mouse model for intraportal islet transplantation with limited hepatic lobe as a graft site. Transplantation 82, 712-715, 2006

77. Yamada Y, Fukuda K, Fujimoto S, Hosokawa M, Tsukiyama K, Nagashima K, Fukushima M, Suzuki H, Toyoda K, Sassa M, Funakoshi S, Inagaki N, Taniguchi A,

T. Sato S, Matsumoto S, Tanaka K, Seino Y. SUIT, secretory units of islets in transplantation: an index for therapeutic management of islet transplanted patients and its application to type 2 diabetes. Diabetes Res Clin Pract 74, 222-6, 2006

78. Iwanaga Y, Matsumoto S, Okitsu T, et al. Living donor islet transplantation, the

alternative approach to overcome the obstacles limiting transplant. Ann N Y Acad Sci 79; 335-9, 2006

79. Noguchi H, Matsumoto S, Okitsu T, et al. Evaluation of islet transplantation from non-heart-beating donors. Am J Transplant 6, 2476-2482, 2006

80. Matsumoto S, Okitsu T, Iwanaga Y, et al. The follow up study of the first successful

living donor islet transplantation. Transplantation 82, 1629-33, 2006

81. Miki A, Rivas-Carrillo J, N-Alvarez N, S-Gutierrez A, Chen Y, Tanaka K,

Narushima M, Tabata Y, Okitsu T, Noguchi H, Matsumoto S, Tanaka N, Kobayashi N. Maintenance of neovascularization at the implantation site of an artificial device by bFGF and endothelial cell transplant. Cell Transplant 15, 325-334, 2006

82. Sato E, Shimomura M, Masuda S, Yano I, Katsura T, Matsumoto S, Okitsu T,

Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Inui K. Temporal decline in sirolimus elimination immediately after pancreatic islet transplantation. Drug Metab Pharmacokinet. 21, 492-500, 2006

83. Rivas-Carrillo JD, Navarro-Alvarez N, Soto-Gutierrez A, Okitsu T, Chen Y, Tabata

Y, Misawa H, Noguchi H, Matsumoto S, Tanaka N, Kobayashi N. Amelioration of diabetes in mice after single-donor islet transplantation using the controlled release of gelatinized FGF-2. Cell Transplant 15, 939-944, 2006

84. Noguchi H, Xu G, Matsumoto S, Kaneto H, Kobayashi N, Bonner-Weir S, Hayashi

S. Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology. Cell Transplant 15, 929-38, 2006

85. Noguchi H, Ueda M, Matsumoto S, Kobayashi N, Hayashi S. BETA2/NeuroD protein transduction requires cell surface heparan sulfate proteoglycans. Human

Gene Therapy 18, 10-17, 2007

86. Noguchi H, Nakai Y, Ueda M, Masui Y, Futaki S, Kobayashi N, Hayashi S,

Matsumoto S. Activation of JNK pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor. Diabetologia 50, 612-619,

2007

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87. Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, Noguchi H, Okitsu T,

Chen Y, Yuasa T, Haruo M, Tabata Y, Jun HS, Matsumoto S, Fox IJ, Tanaka N, Kobayashi N. Cell-permeable Pentapeptide V5 Inhibits Apoptosis and Enhances

Insulin Secretion, Allowing Experimental Single-donor Islet Transplantation In Mice. Diabetes 56, 1259-1267, 2007

88. Noguchi H, Matsumoto S et al. Comparison of M-Kyoto solution and histidine-tryptophan-ketoglutarate solution with a trypsin inhibitor for pancreas preservation

in islet transplantation. Transplantation 84, 655-658, 2007

89. Onaca N, Naziruddin B, Matsumoto S, Noguchi H, Klintmalm G, Levy M.

Pancreatic islet cell transplantation: Update and new developments. Nutrition in Clinical Practice 22, 485-493, 2007

90. Matsumoto S, Noguchi H, Naziruddin B, Onaca N, Jackson A, Hatanaka N, Okitsu

T, Kobayashi N, Klintmalm G, Levy M. Improvement of pancreatic islet cell

isolation for transplantation. Baylor University Medical Center Proceedings 20, 357-362, 2007

91. Ikemoto M, Matsumoto S, Egawa H, Okitsu T, Iwanaga Y, Umemoto S, Itoh H,

Murayama, H, Fujita M. A case with transient increases in serum S100A8/A9 levels

implying acute inflammatory responses after pancreatic islet transplanta tion Ann Clin Biochem 44:570-2, 2007

92. Ueda M, Matsumoto S, Hayashi S, Kobayashi N, Noguchi H. Cell surface heparan

sulfate proteoglycans mediate the internalization of PDX-1 protein. Cell Transplant

17, 91-97, 2008

93. Matsumoto S, Noguchi H, Hatanaka N, Kobayashi N, Jackson A, Naziruddin B, Levy F. Estimation of Donor Usability for Islet Isolation with The Modified Ricordi Method. Transplant Proc 40, 362-363, 2008

94. Matsumoto S, Noguchi H, et al. Evaluation of engraftment after single islet transplantation from a brain dead donor by the secretory unit of islet transplant

objects (SUITO) index. Transplant Proc 40, 364-366, 2008

95. Liu X, Matsumoto S, Noguchi H, et al. Continuous but not occasional, oral ethanol intake reduces the success of intraportal transplanted islets of Langerhans: an experimental study. Transplant Proc 40, 441-443, 2008

96. Jackson A, McWilliams C, Kaizer E, Chaussabel D, Glaser C, Noguchi H,

Matsumoto S, Levy MF, Naziruddin B. Gene expression profiling of human pancreatic islets undergoing a simulated process of instant blood-mediated inflammatory reaction. Transplant Proc 40, 430-432, 2008

97. Noguchi H, Matsumoto S, Ueda M, Hayashi S, Kobayashi N, Naziruddin B, Levy

M. Method for isolation of mouse pancreatic stem cells. Transplant Proc 40, 422-423, 2008

98. Noguchi H, Matsumoto S, Kobayashi N, Hayashi S, Iwanaga Y, Nagata H, Jackson A, Naziruddin B, Okitsu T, Levy M. Effect of JNK inhibitor during islet isolation

and transplantation. Transplant Proc 40, 379-381, 2008

99. Navarro-Alvarez N, Rivas-Carrillo JD, Soto-Gutierrez A, Yuasa T, Okitsu T,

11

Noguchi H, Matsumoto S, Takei J, Tanaka N, Kobayashi N. Reestablishment of microenvironment is necessary to maintain in vitro and in vivo human islet function.

Cell Transplant 17, 111-119, 2008

100. Noguchi H, Ueda M, Hayashi S, Kobayashi N, Okitsu T, Iwanaga Y, Nagata H, Nakai Y, Matsumoto S. Ductal injection of preservation solution increases islet yields in islet isolation and improves islet graft function. Cell Transplant 17, 69-81,

2008

101. Noguchi H, Yamada Y, Okitsu T, Iwanaga Y, Nagata H, Kobayashi N, Hayashi S, Matsumoto S. Secretory Unit of Islet in Transplantation (SUIT) and Engrafted Islet Rate (EIR) indexes are useful for evaluating single islet transplantation. Cell

Transplant 17, 121-128, 2008

102. Noguchi H, Matsumoto S. Islet transplantation at the Diabetes Research Institute Japan. J Hepatobiliary Pancreat Surg 15, 278-283, 2008

103. Liu X, Matsumoto S, Okitsu T, et al. Analysis of donor- and isolation-related variables from non-heart-beating donors (NHBDs) using the Kyoto islet isolation

method. Cell Transplant 17, 649-656, 2008

104. Navarro-Alvarez N, Rivas-Carrillo JD, Soto-Gutierrez A, Yuasa T, Okitsu T, Noguchi H, Matsumoto S, Takei J, Tanaka N, Kobayashi N. Reestablishment of

microenvironment is necessary to maintain in vitro and in vivo human islet function. Cell Transplant 17, 111-9, 2008

105. Yuasa T, Yamamoto T, Rivas-Carrillo JD, Chen Y, Navarro-Alvarez N, Soto-

Guiterrez A, Noguchi H, Matsumoto S, Tanaka N, Kobayashi N. Laparoscopy-

assisted creation of a liver failure model in pigs. Cell Transplant 17, 187-93, 2008

106. Shintaku H, Okitsu T, Kawano S, Matsumoto S, Suzuki T, Kanno I, Kotera H. Effects of fluid dynamic stress on fracturing of cell-aggregated tissue during purification for islets of Langerhans transplantation. Journal of Physics D: Applied

Physics 41:(115507-1)-(115507-9), 2008

107. Matsumoto S, Noguchi H, Hatanaka N, Shimoda M, Kobayashi N, Jackson A, Onaca N, Naziruddin B, Levy M. Estimation of Donor Usability for Islet Transplantation in the United States with the Kyoto Islet Isolation Method. Cell

Transplant 18, 549-556, 2009

108. Matsumoto S, Noguchi H, Hatanaka N, Shimoda M, Kobayashi N, Jackson A, Onaca N, Naziruddin B, Levy M. SUITO index for evaluation of efficacy of single donor islet transplantation. Cell Transplant 18, 557-562, 2009

109. Noguchi H, Oishi K, Ueda M, Yukawa H, Hayashi S, Kobayashi N, Levy M,

Matsumoto S. Establishment of mouse pancreatic stem cell line. Cell Transplant 18, 563-571, 2009

110. Noguchi H, Levy M, Kobayashi N, Matsumoto S. Pancreas preservation by the Two-Layer Method: Does it have a beneficial effect compared with simple

preservation in University of Wisconsin solution? Cell Transplant 18, 497-503, 2009

111. Yuasa T, Rivas-Carrillo JD, Navarro-Alvarez N, Soto-Gutierrez A, Kubota Y,

Tabata Y, Okitsu T, Noguchi H, Matsumoto S, Nakaji S, Tanaka N, Kobayashi N. Neovascularization induced around an artificial device implanted in the abdomen by

the use of gelatinized fibroblast growth factor 2. Cell Transplant 18, 683-688, 2009

12

112. Ikemoto T, Noguchi H, Shimoda M, Naziruddin B, Jackson A, Tamura Y, Fujita Y,

Onaca N, Marlon FL, Matsumoto S. Islet transplantation in USA. J Hepatobiliary Pancreat Surg 16, 118-23, 2009

113. Jackson A, Levy M, Matsumoto S, Noguchi H, Connolly JE, Naziruddin B.

Evidence for induced expression of HLA class II on human islets: Possible

mechanism or HLA sensitization in transplant recipients. Transplantation 87, 500-6, 2009

114. Noguchi H, Hatanaka N, Matsumoto S. Renal and islet transplantation from non-

heart-beating donors. Organ Donation and Cardiac Failure, Talbot, D’Alessandro

edit. OXFORD UNIVERSITY PRESS 289-305, 2009

115. Sato E, Yano I, Shimomura M, Masuda S, Katsura T, Matsumoto S, Okitsu T,

Iwanaga Y, Uemoto S, Inui K. Larger dosage required for everolimus than sirolimus to maintain same blood concentration in two pancreatic islet transplant patients with tacrolimus. Drug Metab Pharmacokinet 24, 175-9, 2009

116. Onaca N, Naziruddin B, Randall HB, Meler JD, Sanchez EQ, Matsumoto S,

Noguchi H, Jackson A, Diamond NG, Klintmalm GB, Levy MF. False aneurysm of a hepatic artery branch complicating intrahepatic islet transplantation. Transpl Int 22, 663-6, 2009

117. Noguchi H, Ikemoto T, Naziruddin B, Jackson A, Shimoda M, Fujita Y, Chujo D,

Takita M, Kobayashi N, Onaca N, Levy M, Matsumoto S. Iodixanol controlled-density gradient during islet purification improves recovery rate in human islet isolation. Transplantation 87, 1629-35, 2009

118. Noguchi H, Matsumoto S, Onaca N, Naziruddin B, Jackson A, Ikemoto T, Shimoda

M, Fujita Y, Chujo D, Iwanaga Y, Nagata H, Okitsu T, Kobayashi N, Ueno H, Chaussabel D, Grayburn P, Banchereau J, Levy MF. Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet

graft function. Hum Gene Ther. 20, 73-85, 2009

119. Noguchi H, Ueda M, Hayashi S, Kobayashi N, Okitsu T, Iwanaga Y, Nagata H, Liu X, Kamiya H, Matsumoto S. Comparison of trypsin inhibitors in preservation solution for islet isolation. Cell Transplant 18,541-7,2009

120. Nakahara H, Misawa H, Hayashi T, Matsumoto S, Kobayashi N, et al. Bone repair

by transplantation of hTERT-immortalized human mesenchymal stem cells in mice. Transplantation 88, 346-53, 2009

121. Matsumoto S, Noguchi H, Shimoda M, Ikemoto, Naziruddin B, Jackson A, Tamura Y, Olsen G, Fujita Y, Chujo D, Takita M, Kobayashi N, Onaca N, Levy MF. Seven

consecutive successful clinical islet isolations with pancreatic ductal injection. Cell Transplant 19, 291-297, 2010

122. Matsumoto S. Islet cell transplantation for type 1 diabetes. Journal of Diabetes 2, 16-22, 2010

123. Noguchi H, Naziruddin B, Jackson A, Shimoda M, Ikemoto T, Fujita Y, Chujo D,

Takita M, Kobayashi N, Onaca N, Levy MF, Matsumoto S. Low-temperature

preservation of isolated islets is superior to conventional islet culture before islet transplantation. Transplantation 89, 47-54, 2010

13

124. Takita M, Naziruddin B, Matsumoto S, Noguchi H, Shimoda M, Chujo D, Itoh T,

Sugimoto K, Onaca N, Lamont JP, Lara LF, Levy MF. Variables associated with islet yield in autologous islet transplantation for chronic pancreatitis. Baylor

University Medical Center Proceedings 23, 115-120, 2010

125. Hatanaka N, Takita M, Yamaguchi T, Kami M, Matsumoto S. Interests in beta-cell

replacement therapies among Japanese patients with type 1 diabetes. Diab. Res. Clin.

Pract. 89, e5-e8, 2010

126. Hatanaka N, Matsumoto S, Tanaka Y, Kami M. Why do Japan’s advanced medical

treatments never get ahead? Keio Journal of Medicine 59, 46-51, 2010

127. Matsumoto S, Hatanaka N. Islet transplantation from live related donor. Islet

Transplantation: Biology, Immunology, and Clinical Applications, in press

128. Matsumoto S, Hirofumi Noguchi, Naoya Kobayashi, Angelika Gruessner and David E.R. Sutherland. Pancreas preservation, Organ Preservation for Transplantation 3rd edition, Luis H Toledo-Pereyra edit, LANDES BIOSCIENCE in press

129. Noguchi H, Matsushita M, Kobayashi N, Levy M, Matsumoto S. Recent advances in protein transduction technology. Cell Transplant in press

130. Noguchi H, Naziruddin B, Jackson A, Shimoda M, Ikemoto T, Fujita Y, Chujo D, Takita M, Kobayashi N, Onaca N, Hayashi S, Levy M, Matsumoto S.

Characterization of human pancreatic progenitor cells. Cell Transplant in press

131. Noguchi H, Naziruddin B, Onaca N, Jackson A, Shimoda M, Ikemoto T, Fujita Y,

Kobayashi N, Levy M, Matsumoto S. Comparison of modified Celsior solution and M-Kyoto solution for pancreas preservation in human islet isolation. Cell Transplant

in press

132. Noguchi H, Kobayashi N, Matsumoto S. Technologies to Improve Human Islet

Transplantation, Methods in Bioengineering, Robert Langer and Martin L. Yarmush edit. in press

133. Ikemoto T, Matsumoto S, Itoh T, Noguchi H, Tamura Y, Jackson AM, Shimoda M,

Naziruddin B, Onaca N, Yasunami Y, Levy MF. Assessment of islet quality

following international shipping of more than 10,000 km. Cell Transplant in press

134. Takita M, Matsumoto S, Noguchi H, Shimoda M, Ikemoto T, Chujo D, Tamura Y, Olsen GS, Naziruddin B, Purcell K, Onaca N, Levy MF. Adverse events in clinical islet transplantation: One institutional experience. Cell Transplant in press

135. Naziruddin B, Matsumoto S, Noguchi H, Takita M, Shimoda M, Fujita Y, Chujo D,

Tate C, Onaca N, Lamont K, Kobayashi N, Levy MF. Improved pancreatic islet isolation outcome in autologous transplantation for chronic pancreatitis. Cell Transplant in press

136. Shimoda M, Noguchi H, Fujita Y, Takita M, Ikemoto T, Chujo D, Naziruddin B,

Levy MF, Kobayashi N, Grayburn PA, Matsumoto S. Improvement of porcine islet isolation by Aralast inhibition of trypsin with pancreatic ductal preservation method. Cell Transplant in press

14

137. Shimoda M, Noguchi H, Fujita Y, Takita M, Ikemoto T, Chujo D, Naziruddin B,

Levy MF, Kobayashi N, Grayburn PA, Matsumoto S. Islet purification method using large bottle effectively achieves high islet yield from pig pancreas. Cell Transplant

in press

138. Noguchi H, Naziruddin B, Shimoda M, Fujita Y, Chujo D, Takita M, Peng H,

Sugimoto K, Itoh T, Kobayashi N, Onaca N, Levy MF, Matsumoto S. Evaluation of osmolality of density gradient for human islet purification. Cell Transplant in press

139. Noguchi H, Naziruddin B, Jackson A, Shimoda M, Ikemoto T, Fujita Y, Chujo D,

Takita M, Peng H, Sugimoto K, Itoh T, Kobayashi N, Onaca N, Levy MF,

Matsumoto S. Fresh islets are more effective for islet transplantation than cultured islets. Cell Transplant in press

140. Noguchi H, Naziruddin B, Jackson A, Shimoda M, Fujita Y, Chujo D, Takita M,

Peng H, Sugimoto K, Itoh T, Kobayashi N, Ueda M, Okitsu T, Iwanaga Y, Nagata H,

Liu X, Kamiya H, Onaca N, Levy MF, Matsumoto S. Comparison of ulinastatin, gabexate mesilate, and nafamostat mesilate in preservation solution for islet isolation.

Cell Transplant in press

141. Shimoda M, Chen S, Noguchi H, Matsumoto S, Grayburn PA. In vivo non-viral

gene delivery of human vascular endothelial growth factor improves the revascularization and restoring euglycemia after human islet transplantation in

mouse liver. Diabetologia in press

142. Ikemoto T, Noguchi H, Fujita Y, Takita M, Shimoda M, Sugimoto K, Jackson A,

Naziruddin B, Shimada M, Levy MF, Matsumoto S. New step-wise cooling system for short-term porcine islet preservation. Pancreas in press

143. Takita M, Naziruddin B, Matsumoto S, Noguchi H, Shimoda M, Chujo D, Itoh T,

Sugimoto K, Onaca N, Lamont J, Lara LF, Levy MF. Implication of pancreatic

image findings in total pancreatectomy with islet autotransplantation for chronic pancreatitis. Pancreas in press

144. Takita M, Naziruddin B, Matsumoto S, Noguchi H, Shimoda M, Chujo D, Sugimoto

K, Onaca N, Lamont J, Lara LF, Levy MF. Reconstruction of pancreatic duct for

previous Puestow operation for an islet auto-transplantation. Transplantation in

press.

145. Matsumoto S, Noguchi H, Takita M, Shimoda M, Tamura Y, Olsen G, Chujo D,

Sugimoto K, Itoh T, Naziruddin B, Onaca N, Levy FM. Excellence of SUITO index

for assessing clinical outcome of islet transplantation. Transplant Proc in press

146. Takita M, Naziruddin B, Matsumoto S, et al. Body Mass Index Reflects Islet

Isolation Outcome in Islet Autotransplantation for Patients with Chronic Pancreatitis.

Cell Transplant in press

147. Shimoda M, Matsumoto S, et al. Assessment of human islet isolation with four

different collagenases. Transplant Proc in press

15

148. Matsumoto S, Noguchi H, Takita M, Shimoda M, Tamura Y, Olsen G, Chujo D,

Sugimoto K, Itoh T, Naziruddin B, Onaca N, Levy MF. Super high dose islet

transplantation is associated with high SUITO index and prolonged insulin

independence: A case report. Transplant Proc in press

149. Matsumoto S, Noguchi H, Takita M, Shimoda M, Tamura Y, Olsen G, Naziruddin

B, Onaca N, Levy MF. ET-Kyoto ductal injection and density-adjusted purification

combined with potent anti- inflammatory strategy facilitated single donor islet

transplantation: Case reports. Transplant Proc in press

150. Shimoda M, Matsumoto S, et al. Improved method of human islet isolation for

young donors. Transplant Proc in press

151. Takita M, Matsumoto S, Noguchi H, Shimoda M, Chujo D, Itoh T, Sugimoto K,

Tamura Y, Olsen GS, Naziruddin B, Onaca N, Levy MF. Secretory unit of islet

transplant objects (SUITO) index can predict outcome of intravenous glucose

tolerance test. Transplant Proc in press

152. Peng H, Olsen GS, Tamura Y, Noguchi H, Matsumoto S, Marlon MF, Naziruddin B.

Inhibition of pro- inflammatory cytokines induced response in human islets by

Withaferin A. Transplant Proc in press

153. Noguchi H, Naziruddin B, Shimoda M, Fujita Y, Chujo D, Takita M, Peng H,

Sugimoto K, Ito T, Kobayashi N, Onaca N, Levy MF, Matsumoto S. Comparison of

fresh and cultured islets from human pancreata. Transplant Proc in press

154. Noguchi H, Naziruddin B, Shimoda M, Fujita Y, Chujo D, Takita M, Peng H,

Sugimoto K, Ito K, Kobayashi N, Onaca N, Levy FM, Matsumoto S. Induction of

human pancreatic progenitor cells into insulin-producing cells by protein

transduction technology. Transplant Proc in press

155. Chen S, Shimoda M, Wang MY, Ding J, Noguchi H, Matsumoto S, Grayburn PA.

Regeneration of pancreatic islets in vivo by ultrasound-targeted gene therapy. Gen

Ther 2010 May 27 [Epub ahead of print]

156. Saitoh T, Gotoh M, Satomi S, Uemoto S, Kenmoti T, Itoh T, Kuroda Y, Yasunami

Y, Matsumoto S. Islet transplantation employing donors after cardiac death: Report

of the Japan Islet Transplantation Registry. Transplantation in press

157. Takita M, Matsumoto S, Noguchi H, Shimoda M, Chujo D, Sugimoto K, Itoh T,

16

Lamont JP, Lara LF, Onaca N, Naziruddin B, Klintmalm GB, Levy MF. One

hundred human islet isolations at Baylor Research Institute. Proc Bayl Univ Med

Cent in press

Japanese

158. Matsumoto S, Onoyama H, Kuroda Y, Yamamoto M, Saitoh Y. Long-term follow-up study of 31 total pancreatectomy patients. Journal of the Japan Pancreas Society, 11, 18-28, 1996

159. Matsumoto S, Kuroda Y, Saitoh. Current status and problems of pancreas

preservation. Y. Low Temp Med 22, 245-250, 1996

160. Matsumoto S, Kuroda Y, Kim Y, Suzuki Y, Ku Y, Hamano M, Saitoh Y. The effect

of thromboxaneA2 synthesis inhibitor (OKY046) on resuscitation of ischemically damaged pancreas graft by the two-layer method. Organ biology 3, 59-65, 1996

161. Matsumoto S, et al Local Anesthesia, Visual Surgical Manual 1997

162. Matsumoto S. Islet and pancreas transplantation; Current progresses and perspectives. Bio Clinica 14, 247-252, 1999

163. Matsumoto S, Tanaka K. Current progress of clinical islet transplantation. Journal of

clinical and experimental medicine 204, 506-507, 2003

164. Matsumoto S. Current Overview of Tissue Banking in the United States. Blood

Products in Next Generation, Hisami Ikeda edit 17-26, 2003

165. Matsumoto S Islet Transplantation for the treatment of diabetes, Diabetes Book

(Yazawa Science office) 2003

166. Yamada Y, Matsumoto S et al Successful Treatment of a Japanese Type 1 Diabetic

Patient by Islet Transplantation from Non-heart-beating Donors. Journal of the Japan Diabetes Society 47: 945-950, 2004

167. Kenmochi T, Matsumoto S et al Manual for Islet Transplantation Ed. The Japan

Society for Pancreas and Islet Transplantation 2004

168. Matsumoto S Islet and Pancreas Transplantation. Current status and future. Junkan

plus 4: 11-12, 2004

169. Matsumoto S Islet Transplantation Obesity and Diabetes (Tansui-sha) 3; 982-984,

2004

170. Matsumoto S Islet transplantation for the treatment of sever diabetes Medical Consultation & New Remedies 51: 891, 2004

171. Matsumoto S, Tanaka K Living donor islet transplantation Journal of clinical and experimental medicine 213: 765, 2005

172. Matsumoto S Current topics surrounding Islet Transplantation 「The Latest Diabetes

Treatment」2005

17

173. Matsumoto S Islet Transplantation –The first Case in Japan－ Progress of

Molecular Diabetology 2005

174. Matsumoto S Islet Transplantation Current Japanese Status and Future Manual for Type1 Diabetes Part 2 (Japan IDDM network Ed.)

175. Matsumoto S Islet Transplantation Clinical Immunology 63: 695-699, 2005

176. Matsumoto S Islet Transplantation Endocrinology Diabetology 20: 503-510, 2005

177. Matsumoto S Islet Transplantation for the treatment of Sever Diabetes Medical

Report Toyama1385; 8-10, 2005

178. Matsumoto S Clinical Islet Transplantation; surgical pint of view. Japanese Journal of Diabetes Master Clinician 3: 614-618, 2005

179. Matsumoto S Surgical Diabetes Treatment Japanese Journal of Diabetes Master Clinician 3: 629-633, 2005

180. Matsumoto S Islet Transplantation from Non-heart beating and living donors

Medical Asahi 34: 60-61, 2005

181. Matsumoto S Islet Transplantation, Current Status and Future Letter of Shizuoka

Kidney Bank 21: 4, 2005

182. Matsumoto S Current Status Islet Transplantation Therapy The Japanese Journal of

Nursing Arts 51: 41-44, 2005

183. Matsumoto S Indication for islet and pancreas transplantation. Pharma Navigator (Diabetes Version) 100-108, 2005

184. Okitsu T, Matsumoto S et al Technology for Clinical Islet Transplantation. Regenerative Medicine 2005; 3: 81-89.

185. Noguchi H, Matsumoto S et al Effect of Protein Transduction of PDX-1 for

Regeneration of Islet PDX-1 Regenerative Medicine 8: 19-24, 2005

186. Noguchi H, Matsumoto Set al Establishment of New Induction Method for beta cell

regeneration. Transplantation Now18: 424-428, 2005

187. Okitsu T, Matsumoto S et al Islet Transplantation at Kyoto University

Transplantation Now 18; 409-414, 2005

188. Noguchi H, Matsumoto S, et al Protein Transduction System for the development

of new drug and application for islet transplantation Journal of Okayama Medical Association 117; 105-108, 2005

189. Nagata H, Matsumoto S, et al Progress of Transplantation Therapy for Type 1

Diabetes. Mebio 22; 87-91, 2005

190. Matsumoto S Current Status of Islet Transplantation. Japanese Journal of

Transplantation 2005; 40; 348-357, 2005

191. Matsumoto S Current Status and Perspective of Tissue Transplantation; Islet

Transplantation Journal of Japan Surgical Society 107, 86-89, 2006

18

192. Matsumoto S Clinical experience of mTOR inhibitor for islet transplantation.

Transplantation Now 19, 184-189, 2006

193. Matsumoto S, et al. Cutting Edge Islet Transplantation. Medical Science Digest 32; 4-5, 2006

194. Matsumoto S Current Status of Islet Transplantation Annual Review Diabetes Metabolism Endocrinology 2006; 50-55, 2006

195. Matsumoto S Pancreas and Islet of Langerhans Transplantation for Type 1 Diabetes,

current status and future: Brush Up! CDE Japanese Journal of Diabetes Master

Clinician 4; 135-139, 2006

196. Matsumoto S Living donor islet transplantation Diabetes Journal 34, 29-32, 2006

197. Matsumoto S Islet Transplantation Pros and Cons Diabetes Frontier 17, 336-341,

2006

198. Matsumoto S Islet Transplantation Brain Death & Resuscitation 18, 29-35, 2006

199. Matsumoto S Islet Transplantation The Medical Frontline 61, 75-79, 2006

200. Matsumoto S Islet of Langerhans Transplantation Organ Biology 13, 161-168,

2006

201. Matsumoto S Current Status of Islet Transplantation. Gastroenterology-state of the

arts II. Disease of hepato-biliary system and pancreas version 3 Journal of clinical and experimental medicine 491-494, 2006

202. Noguchi H, Matsumoto S, et al Activation of c-Jun NH2-terminal kinase (JNK)

during islet isolation and effect of JNK inhibitor. The Japanese Journal of Bilio-

Pancreatic Physiology 22, 35-40, 2006

203. Matsumoto S Progress of islet transplantation for the treatment of type 1 diabetes The Journal of the Japan Pediatric Society 100; 1378-1384, 2006

204. Nagata H, Matsumoto S, et al Islet Cell Transplantation from Non-Heart-Beating Donor. The Japanese Journal of Bilio-Pancreatic Physiology 22, 41-46, 2006

205. Matsumoto S Islet Transplantation Journal of the Japan Diabetes Society 49,

899-901, 2006

206. Matsumoto S. Pancreas and Islet Transplantation, Current status and perspective The

Current Medicine 54, 213-216, 2006

207. Matsumoto S Islet Cell Transplantation. The Current Medicine 54, 247-255, 2006

208. Matsumoto S Living donor pancreas and islet transplantation for diabetes. Current

Therapy in Diabetes Mellitus 2007-2009 18-22, 2007 209. Matsumoto S Living donor islet transplantation The Medical Frontline 62, 125-129,

2007

19

210. Matsumoto S Islet Transplantation-Cell Transplantation for type 1 diabetes. Journal of Clinical and Experimental Medicine 220, 1245-1248, 2007

211. Matsumoto S Current status of islet transplantation for type 1 diabetes1 Infection

Inflammation Immunity) 37, 92-94, 2007

212. Matsumoto S Clinical results of islet transplantation for type 1 diabetes and

perspective. Pediatrics of Japan 48, 313-320, 2007

213. Matsumoto S Islet Transplantation Question & Answer for Medical Staff 372-375, 2007

214. Matsumoto S Living donor pancreas and islet transplantation Handbook for Management of Childhood and Adolescent Diabetes Mellitus 47-51, 2007

215. Matsumoto S, Topics for Islet Transplantation. New perspective for the treatment of

diabetes. Yoshioka N edit, Japan Association for Diabetes Education and Care/

Ishiyaku-shuppan Practice 121-128, 2008

216. Matsumoto S, Islet Transplantation Diabetes Frontier 19, 220-223, 2008

217. Hatanaka N, Matsumoto S, Current status of Islet Transplantation Therapy

Hematology Frontier 18; 39-45, 2008

218. Matsumoto S Islet Transplantation for the treatment of diabetes, Diabetes Book (Yazawa Science office) 2008

219. Matsumoto S Current Status of Islet Transplantation Internal Medicine 101, 105-108, 2008

220. Matsumoto S, Pancreas and Islet Transplantation Current Library of Diabetes 9,

164-169, 2008

221. Matsumoto S. Bio-artificial islet transplantation using porcine islets. The Medical

Frontline 64, 211-216, 2009

222. Matsumoto S et al. Islet transplantation as beta-cell replacement therapy for diabetes.

Clinical Engineering 20, 2009

223. Shimoda M, Matsumoto S. Pancreas and Islet Transplantation Popular Medicine 261, 157-160, 2009

224. Matsumoto S. Islet Transplantation Current Status and Perspective Current Library of Diabetes 10, 81-86, 2009

225. Matsumoto S, Current status and new direction of islet transplantation. Experimental

Medicine 6, 1373-1376, 2010

226. Matsumoto S. Current Status of Islet Transplantation. Domestic and international

outcomes and future perspective. Sakae 9, 17-20, 2010

227. Kamiya H, Matsumoto S et al. Analysis of process for establishing the technique of

islet isolation with non-heart-beating-donor. The Japanese Journal of Bilio-Pancreatic Physiology in press

20

228. Matsumoto S Islet transplantation and regenerative medicine for the possibility of curing type 1 diabetes. Bios in press

229. Matsumoto S et al. Evidence-based Practice Guideline for the Treatment of Diabetes

in Japan, 3rd edition. The Japan Diabetes Society in press

230. Matsumoto S et al. Handbook for Management of Childhood and Adolescent

Diabetes mellitus, 3rd edition. The Japan Diabetes Society in press

231. Matsumoto S. Islet Transplantation. Diabetes Frontier in press

Presentation

International Meetings

1. Matsumoto S, Zhang HJ, Gilmore T, Van der Burg MP, Sutherland DER, Hering BJ. Large-scale isopycnic islet purification utilizing non-toxic, endotoxin-free media facilitates

immediate single-donor pig islet allograft function. American Society of Transplant Surgeon 1998, Chicago

2. Matsumoto S, Shibata S, Kirchihof N, Hiraoka K, Sageshima J, Zhang X, Gilmore T, Ansite

J, Zhang H, Sutherland DER, Hering BJ. Immediate reversal of diabetes in primates

following intraportal transplantation of porcine islets purified on a new histidine-lactobionate- iodixanol gradient. American Society of Transplantation, 1999, Chicago

3. Matsumoto S, Rigely T, Qually S, et al. Two-layer (University of Wisconsin solution/

perfluorocarbon) method of human pancreas preservation prior to islet isolation improved

the yield and viability. The Joint American Transplant Meeting 2001 May 11-16

4. Matsumoto S, Chawla J, Reems J, et al. Evaluation of human pancreas preserved by the two-layer (UW solution/ perfluorocarbon) method prior to islet isolation. The Joint American Transplant Meeting 2001 May 11-16

5. Matsumoto S, Sweet I, Strong DM, et al. Additional short-term (5hours) preservation of

pancreas by the two-layer (UW solution/ Perfluorocarbon + oxygen) method prior to islet isolation improved quantity and quality of isolated non-human primate islets. The Joint American Transplant Meeting 2001 May 11-16

6. Stevens RB, Matsumoto S, Rigely T, et al. Ischemically damaged human pancreases (Px)

can be resuscitated by the two-layer method before islet isolation: implication for clinical islet transplantation. The Joint American Transplant Meeting 2001 May 11-16

7. Stevens RB, Qualley S, Matsumoto S et al. Pancreas storage with the two-layer method (TLM) dramatically extends the organ preservation period before isolations of human islets.

The Joint American Transplant Meeting 2001 May 11-16 8. Matsumoto S, Reems J, Strong DM, et al. The two-layer method extends the preservation

time of human pancreata as assessed by the Edmonton protocol. The 8 th international pancreas and islet transplantation association conference 2001 June 12-15

9. Matsumoto S, Rigley T, March C, et al. Inhibition of trypsin activity during islet isolation

improves islet yield from human and non-human primate pancreata. The 8th international

pancreas and islet transplantation association conference 2001 June 12-15

21

10. Matsumoto S, Rigley T, Qualley S et al.Preservation of unpurified islets using the trypsin inhibitor Pefabloc. The 8th international pancreas and islet transplantation association

conference 2001 June 12-15

11. Stevens RB, Matsumoto S, Reems J. Pancreatic tissue ATP levels after two-layer preservation correlate with islet yields from human pancreata The 8th international pancreas and islet transplantation association conference 2001 June 12-15

12. Stevens RB, Matsumoto S, Reems J, et al Successful two-layer preservation of human and

primate pancreata without continuous oxygenation. The 8th international pancreas and islet transplantation association conference 2001 June 12-15

13. Matsumoto S, Rigley T, Stevens RB. Use of the two-layer method plus trypsin inhibition substantially improved islet yield and function in non-human primates. American Transplant

Congress 2002 April 26 - May 1 14. Matsumoto S, Qualley S, Goel S, et al. The effect of the two-layer [University of Wisconsin

solution / perfluorochemical plus O2] method on human islet isolation as assessed by the Edmonton isolation protocol. American Transplant Congress 2002 April 26 - May 1

15. Matsumoto S, Qualley S, Goel S, et al. Improvement of human islet isolation by an

additional short-term (2-8 hours) two-layer method of pancreas preservation prior to islet

isolation. The XIX International Congress of The Transplantation Society 2002 August 25 -30

16. Matsumoto S, Qualley S, Goel S, et al. The newly developed oxygen static charge two-layer

method for pancreas transportation improved human and non human primate islet isolation.

The XIX International Congress of The Transplantation Society 2002 August 25 -30

17. Stevens R, Rigley T, Kuroda Y, Matsumoto S. Improved islet yields from primate and human pancreata after endogenous trypsin inhibition and two-layer pancreas preservation. The XIX International Congress of The Transplantation Society 2002 August 25 -30

18. Stevens R, Rigley T, Kuroda Y, Matsumoto S, et al. Improved islet yields and increased

ATP content of marginal human pancreata after resuscitation by prolonged two-layer method. The XIX International Congress of The Transplantation Society 2002 August 25 -30

19. Matsumoto S, Guangming Z, Hyon S, et al. The effect of Polyphenol on short-term culture

of human islets towards clinical usage. 5th international meeting of the tissue engineering society international 2002 December 8-10

20. Matsumoto S, Guangming Z, Qualley S, et al. Analysis of donor factors affecting human islet isolation with current isolation protocol. The 9th international pancreas and islet

transplantation association conference 2003 July 9 – 11 21. Matsumoto S, Guangming Z, Qualley S, et al. The effect of the two-layer (University of

Wisconsin solution/ Perfluorochemical) method on clinical grade pancreata prior to islet isolation and transplantation. The 9th international pancreas and islet transplantation

association conference 2003 July 9 – 11 22. Matsumoto S, Okitsu T, Iwanaga Y, et al. Efficacy of human islet isolation from tail part of

pancreas for the possible living donor islet transplantation. American Transplant Congress 2004 May 15-19

22

23. Iwanaga Y, Matsumoto S, Okitsu T, et al. The success case of pancreas donation for living donor islet transplantation. 10th World congress of international pancreas and islet transplant

association 2005 May 4-7

24. Matsumoto S, Okitsu T, Iwanaga Y, et al. Insulin independence of unstable diabetic patient after single living donor islet transplantation. 10th World congress of international pancreas and islet transplant association 2005 May 4-7

25. Okitsu T, Matsumoto S, Iwanaga Y, et al. Kyoto islet isolation method- the optimized one

for non-heart-beating donor with highly efficient islet retrieval. 10th World congress of international pancreas and islet transplant association 2005 May 4-7

26. Nagata H, Matsumoto S, Okitsu T, et al. In situ cooling of pancreata from non heart beating donors (NHBDS) prior to procurement for islet isolation. 10th World congress of

international pancreas and islet transplant association 2005 May 4-7 27. Saitoh T, Ise K, Matsumoto S, et al. Islet transplantation program in Japan. 10th World

congress of international pancreas and islet transplant association 2005 May 4-7

28. Noguchi H, Matsumoto S, Okitsu T, et al. Islet transplantation using Kyoto protocol from non heart-beating donors. 10th World congress of international pancreas and islet transplant association 2005 May 4-7

29. Matsumoto S, Yamada Y, Okitsu T, et al. Simple evaluation of secretory unit of islet

transplant objects (SUITO) for living donor and cadaveric donor fresh or cultured islet transplantation. 10th World congress of international pancreas and islet transplant association 2005 May 4-7

30. Yonekawa Y, Okitsu T, Iwanaga Y, Matsumoto S, et al. A new model for mouse

intrahepatic islet transplantation. 10th World congress of international pancreas and islet transplant association 2005 May 4-7

31. Yonekawa Y, Matsumoto S, Okitsu T, et al. A method for large scale porcine islet isolation. 10th World congress of international pancreas and islet transplant association 2005 May 4-7

32. Iwanaga Y, Matsumoto S, Yonekawa Y, et al. The extract of green tea, polyphenol is

effective for cryopreservation of porcine islets. 10th World congress of international

pancreas and islet transplant association 2005 May 4-7

33. Matsumoto S, Okitsu T, Iwanaga Y, et al. Successful islet transplantation for the treatment of type 1 diabetes from non-heart beating donors. American Transplant Congress 2005 May 21-25

34. Matsumoto S, et al. Estimation of donor usability for islet isolation with modified Ricordi

Method. 2007 Joint Conference CTS, IPITA IXA, September 15-20th 2007 Minneapolis 35. Liu X, Matsumoto S, et al. The effect of alcohol intake on engraftment of transplanted islets.

2007 Joint Conference CTS, IPITA IXA, September 15-20th 2007 Minneapolis

36. Matsumoto S, et al. Evaluation of engraftment after single islet transplantation from brain death donor by secretory unit of islet transplant subjects index (SUITO index). 2007 Joint Conference CTS, IPITA IXA, September 15-20th 2007 Minneapolis

23

37. Noguchi H, Matsumoto S, et al. Pancreas preservation with JNK inhibitor protects isolated islets against apoptosis and improves islet graft function. 2007 Joint Conference CTS,

IPITA IXA, September 15-20th 2007 Minneapolis

38. Noguchi H, Matsumoto S, et al. Establishment of mouse pancreatic stem cells line. 2007 Joint Conference CTS, IPITA IXA, September 15-20th 2007 Minneapolis

39. Onaca N, Matsumoto S, et al. Study subject dropout alter pancreatic islet cell transplantation. 2007 Joint Conference CTS, IPITA IXA, September 15-20th 2007 Minneapolis

40. Onaca N, Matsumoto S, et al. Automated, wireless blood glucose collection and reporting

system in islet cell transplantation recipients. 2007 Joint Conference CTS, IPITA IXA,

September 15-20th 2007 Minneapolis

41. Jackson A, Matsumoto S, et al. Gene expression profiling of human pancreatic islets undergoing simulated process of instant blood-mediated inflammatory reaction. 2007 Joint Conference CTS, IPITA IXA, September 15-20th 2007 Minneapolis

42. Okitsu T, Matsumoto S, et al. Islet allografts from non-heart-beating donors in type1

diabetic patients at Kyoto, Japan: Two year follow up. 2007 Joint Conference CTS, IPITA IXA, September 15-20th 2007 Minneapolis

43. Noguchi H, Onaca N, Jackson A, Naziruddin B, Levy F, Matsumoto S. Clinical application of pancreatic ductal presentation in islet transplantation. 2008 American Transplant

Congress May 30th-June 4th 2008 Toronto 44. Okitsu T, Matsumoto S, et al. Three year follow-up after clinical islet transplantation from

donation-after-cardiac-death (DCD) donors to type 1 diabetic patients. 2008 American Transplant Congress May 30th-June 4th 2008 Toronto

45. Matsumoto S, et al. SUITO index for prediction of outcome in clinical islet transplantation.

2008 American Transplant Congress May 30th-June 4th 2008 Toronto

46. Jackson A, Matsumoto S, et al. Complement induced gene expression changes in human

pancreatic islets. 2008 American Transplant Congress May 30th-June 4th 2008 Toronto 47. Shimoda M, Noguchi H, Naziruddin B, Ikemoto T, Jackson A, Onaca N, Levy M, Grayburn

PA, Matsumoto S. New pancreas preservation strategy for successful clinical islet transplantation. XXII International Congress of The Transplantation Society August 10-14

2008 Sydney 48. Naziruddin B, Jackson A, Connolly J, Matsumoto S, et al. Evidence for induced expression

of HLA class II on isolated human pancreatic islets: Possible mechanism for HLA sensitization in transplant recipients. XXII International Congress of The Transplantation

Society August 10-14 2008 Sydney 49. Ikemoto T, Ito T, Jackson A, Shimoda M, Noguchi H, Naziruddin B, Yasunami Y,

Matsumoto S, Levy MF. Super-long distance international shipping. XXII International Congress of The Transplantation Society August 10-14 2008 Sydney

50. Matsumoto S, et al. SUITO-index for assessment of engrafted islet mass in clinical islet

transplantation. XXII International Congress of The Transplantation Society August 10-14

2008 Sydney

24

51. Matsumoto S. New pancreas procurement and preservation strategy for improving islet isolation and transplantation. 10th biannual Cell Transplant Society and the 36th annual

meeting of Japan Society for Organ Preservation and Medical Biology, April 20-21 2009. Okayama

52. Shimoda S, Matsumoto S et al. Improved outcome of porcine islet isolation by inhibition of

trypsin using alfa-1 anti trypsin. 10th biannual Cell Transplant Society and the 36th annual

meeting of Japan Society for Organ Preservation and Medical Biology, April 20-21 2009. Okayama

53. Ikemoto T, Takita M, Sugimoto K, Fujita Y, Shimoda M, Noguchi H, Bashoo N, Onaca N,

Shimada M, Levy MF, Matsumoto S. Basic investigation for islets preserved by a new

effective cooling system. 10th biannual Cell Transplant Society and the 36th annual meeting of Japan Society for Organ Preservation and Medical Biology, April 20-21 2009. Okayama

54. Matsumoto S, et al. Improved pancreatic islet isolation outcome in Autologous

transplantation for choric pancreatitis. 10th biannual Cell Transplant Society and the 36th

annual meeting of Japan Society for Organ Preservation and Medical Biology, April 20-21 2009. Okayama

55. Shimoda M, Fujita Y, Takita M, Ikemoto T, Chujo D, Noguchi H, Naziruddin B, Levy FM,

Kobayashi N, Grayburn PA, Matsumoto S. Islet purification method using large bottles

effectively achieves high islet yield from pig pancreas. 10th biannual Cell Transplant Society and the 36th annual meeting of Japan Society for Organ Preservation and Medical

Biology, April 20-21 2009. Okayama 56. Noguchi H, Naziruddin B, Jackson A, Shimoda M, Ikemoto T, Fujita Y, Chujo D, Takita M,

Kobayashi N, Okitsu T, Iwanaga Y, Nagata H, Ueda M, Onaca N, Levy MF, Matsumoto S. Comparison of ulinastatin, gabexiate mesilate and nafamostat mesilate in preservation

solution for porcine islet isolation. 10th biannual Cell Transplant Society and the 36th annual meeting of Japan Society for Organ Preservation and Medical Biology, April 20-21 2009. Okayama

57. Noguchi H, Ikemoto T, Naziruddin B, Jackson A, Shimoda M, Fujita Y, Chujo D, Takita M,

Kobayashi N, Onaca N, Levy MF, Matsumoto S. Controlled-density gradient by changing the volumetric ratio of iodixanol and purification solutions improves recovery rate in human islet isolation. 10th biannual Cell Transplant Society and the 36th annual meeting of Japan

Society for Organ Preservation and Medical Biology, April 20-21 2009. Okayama

58. Noguchi H, Naziruddin B, Jackson A, Shimoda M, Ikemoto T, Fujita Y, Chujo D, Takita M, Kobayashi N, Onaca N, Levy MF, Matsumoto S. Evaluation of culture/preservation temperature of isolated human islets before transplantation. 10th biannual Cell Transplant

Society and the 36th annual meeting of Japan Society for Organ Preservation and Medical Biology, April 20-21 2009. Okayama

59. Takita M, Matsumoto S, et al. A longitudinal survey of adverse events in clinical islet

transplantation: one institute experience. 10th biannual Cell Transplant Society and the 36th

annual meeting of Japan Society for Organ Preservation and Medical Biology, April 20-21 2009. Okayama

60. Noguchi H, Levy MF, Naziruddin B, Matsumoto S. Islet transplantation and regeneration at

the Baylor Research Institute. 10th biannual Cell Transplant Society and the 36th annual

meeting of Japan Society for Organ Preservation and Medical Biology, April 20-21 2009.

25

61. Matsumoto S, et al. Establishment of reliable islet isolation method using ductal injection technique for clinical islet transplantation. American Transplant Congress 2009. May 30-

June 3 2009. Boston

62. Naziruddin B, Lamount JP, Ikemoto T, Shimoda T, Fujita Y, Takita M, Chujo D, Tae CR, Onaca N, Matsumoto S, Levy M. Improving islet yield in pancreatic islet aut-transplantation for chronic pancreatitis. American Transplant Congress 2009. Boston

63. Onaca N, Naziruddin B, Noguchi H, Shimoda M, Ikemoto T, Klintmalm G, Matsumoto S,

Levy MF, CD4 ATP levels in pancreatic islet transplant recipients. American Transplant Congress 2009. May 30-June 3 2009. Boston

64. Takita M Matsumoto S, et al. Association between the Secretory Unit of Islet Transplant Objects (SUITO) index with quality of life of islet transplant recipients. American

Transplant Congress 2009. May 30-June 3 2009. Boston 65. Matsumoto S et al. Assessment of effect of islet transplantation by SUITO index. American

Transplant Congress 2009. May 30-June 3 2009. Boston

66. Noguchi H, Naziruddin B, Jackson A, Shimoda M, Ikemoto T, Fujita Y, Chujo D, Takita M, Kobayashi N, Onaca N, Levy MF, Matsumoto S. Low-temperature preservation of isolated islets is superior to conventional islet culture before islet transplantation. American

Transplant Congress 2009. May 30-June 3 2009. Boston

67. Ikemoto T, Noguchi H, Ueno H, Jackson A, Fujita Y, Shimoda M, Nazirrudin B, Onaca N, Banchereau J, Levy MF, Matsumoto S. Donor-derived CD11b+ cells induce short-term tolerance by increasing recipient peripheral Foxp3+CD25+CD4+ Tregs through

indoleamine 2,3-dioxygenase activity. American Transplant Congress 2009. May 30-June 3 2009. Boston

68. Shimoda M, Fujita Y, Takita M, Ikemoto T, Noguchi H, Naziruddin B, Levy FM. Grayburn

PA, Matsumoto S. Improved outcome of pig islet isolation by aralast inhibition of trypsin

with pancreatic ductal preservation method. American Transplant Congress 2009. May 30-June 3 2009. Boston

69. Peng H, Olsen G, Tamura Y, Noguchi H, Matsumoto S, Levy FM, Naziruddin B. Inhibition

of pro-inflammatory cytokine induced response in human islets by Withaferin A. The

International Pancreas and Islet Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy

70. Shimoda M, Chen S, Noguchi H, Matsumoto S. Grayburn P. In vivo non-viral gene delivery

of human vascular endothelial growth factor improves human islet survival and function

after transplantation. The International Pancreas and Islet Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy

71. Takita M, Matsumoto S, Chaussabel D, Noguchi H, Shimoda M, Jackson A, Chujo D,

Tamura Y, Olsen G, Naziruddin B, Onaca N, Levy MF. Module analysis for gene

expression in successful single donor islet transplantation. The International Pancreas and Islet Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy

72. Takita M, Matsumoto S, Chaussabel D, Noguchi H, Shimoda M, Jackson A, Chujo D,

Tamura Y, Olsen G, Naziruddin B, Onaca N, Levy MF. Analysis of clinical course of single

donor islet transplantation. The International Pancreas and Islet Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy

26

73. Matsumoto S, Noguchi H, Takita M, Shimoda M, Tamura Y, Olsen G, Chujo D, Sugimoto K, Itoh T, Naziruddin B, Onaca N, Levy M. Excellence of SUITO index for assessing

clinical outcome of islet transplantation. The International Pancreas and Islet Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy

74. Takita M, Matsumoto S, Chaussabel D, Noguchi H, Shimoda M, Jackson A, Chujo D,

Tamura Y, Olsen G, Naziruddin B, Onaca N, Levy MF. Association between secretory unit

of islet transplant objects (SUITO) index and glucose tolerance test after clinical islet transplantation. The International Pancreas and Islet Transplant Association (IPITA)

Meeting 2009. October 12-16, 2009. Venice, Italy 75. Shimoda M, Noguchi H, Naziruddin B, Fujita Y, Chujo D, Takita M, Peng H, Tamura Y,

Olsen G, Sugimoto K, Itoh T, Onaca N, Levy M, Grayburn P, Matsumoto S. Assessment of human islet with four different collagenases. The International Pancreas and Islet Transplant

Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy 76. Shimoda M, Noguchi H, Naziruddin B, Fujita Y, Chujo D, Takita M, Peng H, Tamura Y,

Olsen G, Sugimoto K, Itoh T, Onaca N, Levy M, Grayburn P, Matsumoto S. Improved method of human islet isolation for young donor. The International Pancreas and Islet

Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy 77. Onaca N, Naziruddin B, Noguchi H, Ikemoto T, Shimoda M, Klintmalm G, Matsumoto S,

Levy M. Autotransplantation for pure islets from resected pancreatic remnant with ductal obstruction in chronic pancreatitis. The International Pancreas and Islet Transplant

Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy 78. Shimoda M, Chen S, Noguchi H, Matsumoto S, Grayburn P. Neuro D1 directs

differentiation of cytokeratin 19-positive human pancreatic non-endocrine cells into insulin producing cells. The International Pancreas and Islet Transplant Association (IPITA)

Meeting 2009. October 12-16, 2009. Venice, Italy 79. Noguchi H, Naziruddin B, Shimoda M, Fujita Y, Chujo D, Takita M, Peng H, Sugimoto K,

Itoh T, Kobayashi N, Onaca N, Levy M, Matsumoto S. Induction of human pancreatic progenitor cells into insulin-producing cells by protein transduction technology. The

International Pancreas and Islet Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy

80. Matsumoto S, Noguchi H, Takita M, Shimoda M, Tamura Y, Olsen G, Chujo D, Sugimoto K, Itoh T, Naziruddin B, Onaca N, Levy M. ET-Kyoto ductal injection and density adjusted

purification combined with potent anti-inflammatory strategy facilitated single donor islet transplantation. The International Pancreas and Islet Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy

81. Matsumoto S, Noguchi H, Takita M, Shimoda M, Tamura Y, Olsen G, Chujo D, Naziruddin

B, Onaca N, Levy M. Super high dose islet transplantation is associated with high SUITO index and prolonged insulin independence. The International Pancreas and Islet Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy

82. Naziruddin B, Matsumoto S, Noguchi H, Shimoda M, Fujita Y, Takita M, Chujo D, Tae Ch,

Onaca N, Levy M. Pancreatic ductal preservation improves islet isolation outcome in autologous transplantation for chronic pancreatitis. The International Pancreas and Islet Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy

83. Iwanaga Y, Matsumoto S, Noguchi H, Okitsu T, Kawaguchi Y, Uemoto S. Kyoto islet

isolation method allows efficient islet retrieval from young donor pancreas for clinical use.

27

The International Pancreas and Islet Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy

84. Noguchi H, Naziruddin B, Shimoda M, Fujita Y, Chujo D, Takita M, Peng H, Sugimoto K,

Itoh T, Kobayashi N, Onaca N, Levy M, Matsumoto S. Comparison of fresh and cultured islets from human pancreata. The International Pancreas and Islet Transplant Association (IPITA) Meeting 2009. October 12-16, 2009. Venice, Italy

85. Shimoda M, Chen S, Takita M, Fujita Y, Noguchi H, Sugimoto K, Itoh T, Naziruddin B,

Levy MF, Matsumoto S, Grayburn PA. Neuro D1 promotes beta-cell differentiation from cytokeratine 19-positive human pancreatic non-endocrine cells. American Transplant Congress 2010 May 1-5, 2010, San Diego

86. Noguchi H, Saito I, Shimoda M, Itoh T, Naziruddin B, Levy FM, Matsumoto S. Induction

of pluripotent stem cells from mouse pancreatic stem cells by transient overexpression of Oct3/4 and Klf4. American Transplant Congress 2010 May 1-5, 2010, San Diego

87. Matsumoto S, Noguchi H, Shimoda M, Takita M, Sugimoto K, Ito T, Chujo D, Onaca N, Naziruddin B, Levy MF. Combined IL-1 beta and TNF alpha blockage facilitated single

donor islet transplantation. American Transplant Congress 2010 May 1-5, 2010, San Diego 88. Matsumoto S, Noguchi H, Shimoda M, Takita M, Sugimoto K, Ito T, Tamura Y, Olsen G,

Onaca N, Naziruddin B, Levy MF. ET-Kyoto solution for ductal injection and islet purification improved islet isolation for clinical allo-islet transplantation. American

Transplant Congress 2010 May 1-5, 2010, San Diego 89. Chujo D, Noguchi H, Foucat E, Naziruddin B, Levy MF. Ueno H, Matsumoto S.

Development of GAD65-Specific T cell immunity is associated with chronic graft rejection in islet transplantation. American Transplant Congress 2010 May 1-5, 2010, San Diego

90. Takita M, Naziruddin B, Matsumoto S, Noguchi H, Shimoda M, Itoh T, Sugimoto K,

Tamura Y, Olsen GS, Onaca N, Lamont J, Lara LF, Levy MF. Association between clinical

image studies and the outcome of islet isolation in autologous islet cell transplantation for chronic pancreatitis. American Transplant Congress 2010 May 1-5, 2010, San Diego

91. Takita M, Matsumoto S, Noguchi H, Shimoda M, Chujo D, Itoh T, Sugimoto K, Tamura Y,

Olsen GS, Onaca N, Levy MF. Excellence of SUITO index for predicting insulin

independence in type 1 diabetic patients received islet cell transplantation. American Transplant Congress 2010 May 1-5, 2010, San Diego

92. Matsumoto S, Takita M, Chaussabel D, Noguchi H, Shimoda M, Sugimoto K, Itoh T, Chujo

D, Onaca N, Naziruddin B, Levy MF. Successful single donor islet transplantation by dual

blockage of IL-1 beta and TNF alpha. 70th Scientific Sessions, American Diabetes Association, June 25-29 2010, Orlando FL

93. Chujo D, Noguchi H, Foucat E, Naziruddin B, Levy MF, Banchereau J, Ueno H,

Matsumoto S. 70th Scientific Sessions, American Diabetes Association, June 25-29 2010,

Orlando FL

Presentation in Japanese Meeting

94. Matsumoto S et al. Application of green tea polyphenol for long-term rat islet storage and application to human islets. 2nd Annual Meeting of Japan Regenerative Therapy March 11,

12 2003, Kobe Japan

28

95. Matsumoto S, Shibata S, Sutherland DER et al. Porcine islet transplantation into diabetic

rhesus monkey purified by newly developed islet purification solution. The 6 th Annual Meeting of Japan Xenotransplantation Society. March 29th 03, Kyoto Japan

96. Matsumoto S, Zhang G et al. Improvement of survival of human islets by green tea

polyphenol. The 6th Annual meeting of Japan Tissue Engineering June 12, 13, 2003

97. Matsumoto S, Zhang G, Qualley S et al. Assessment of brain dead donor for islet

transplantation, 2nd Annual Meeting of Japan Tissue Transplantation August 9th 2003 98. Matsumoto S, Okitsu T, Yonekawa Y et al. Development of large amount of porcine islet

isolation. 7th Annual meeting of Japan Xenotransplantation Society, February 28 th 2004, Kyoto Japan

99. Noguchi H, Matsumoto S et al. Effect of PDX-1 protein transduction on islet regeneration

3rd Annual Meeting of Japan Regenerative Therapy, Chiba Japan, March 23-25, 2004

100. Noguchi H, Matsumoto S et al Mechanism of PDX-1 protein transduction 3rd Annual

Meeting of Japan Regenerative Therapy, Chiba Japan, March 23-25, 2004 101. Noguchi H, Xu G, Matsumoto S et al. Trans-induction of pancreatic ductal cell by

enhancement of transcription factor. The 3rd Annual Meeting of Japan Regenerative Therapy, Chiba Japan, March 23-25, 2004

102. Iwanaga Y, Matsumoto S, Zhang G et al. Improving survival of primate and human

islets by green tea polyphenol. The3rd Annual Meeting of Japan Regenerative Therapy,

Chiba Japan, March 23-25, 2004

103. Iwanaga Y, Matsumoto S, et al Possibility of green tea polyphenol for clinical application of culturing human islets. 31st annual meeting of Japan Pancreas and islet transplantation March 26, 27 04, Okayama Japan

104. Saeki T, Matsumoto S, et al. Measurement of color signals of dithizone stained digestion

solution for automatic detection of pancreatic islets. 31st annual meeting of Japan Pancreas and islet transplantation March 26, 27 04, Okayama Japan

105. Matsumoto S, Okitsu T, Iwanaga Y et al. The efficacy of human islet isolation from tail part of pancreas for possible living donor islet transplantation. 31st annual meeting of Japan

Pancreas and islet transplantation March 26, 27 04, Okayama Japan 106. Noguchi H, Matsumoto S, Okitsu T et al The results of human islet isolation at Kyoto

University March 26, 27 04, Okayama Japan

107. Iwanaga Y, Rilo H, Matsumoto S et al. Pancreatectomy and auto-islet transplantation for severe chronic pancreatitis- 22 cases at University of Cincinnati. March 26, 27 04, Okayama Japan

108. Matsumoto S, Noguchi H, Okitsu T et al. Establishment of system of islet isolation

regulated by guideline of Japan Tissue Transplantation. March 26, 27 04, Okayama Japan 109. Noguchi H, Matsumoto S et al. The effect of newly designed immunosuppressant using

protein transduction system on islet transplantation. March 26, 27 04, Okayama Japan

29

110. Yonekawa Y, Okitsu T, Matsumoto S et al. Porcine islet isolation by O’Neil method and effect of intraportal islet transplantation into diabetic SICD mice. March 26, 27 04,

Okayama Japan

111. Okitsu T, Kobayashi N, Matsumoto S et al. Assessment of glucose sensitive insulin producing hepatocyte with middle size animal. March 26, 27 04, Okayama Japan

112. Noguchi H, Matsumoto S, Okitsu T et al. Application of protein transduction of PDX-1 to islet regeneration, March 26, 27 04, Okayama Japan

113. Matsumoto S, Reems J, et al. Assessment of islet isolation from tail part of human

pancreas towards living donor islet transplantation. 104th Annual Meeting of Japan Surgical

Society. April 7-9 04, Osaka, Japan

114. Yonekawa Y, Matsumoto S, et al Evaluation of green tea polyphenol on culture of porcine islets. 104th Annual Meeting of Japan Surgical Society. April 7-9 04, Osaka, Japan

115. Matsumoto S, Okitsu T, Iwanaga Y et al. Living donor and non-heart-beating donor islet transplantation for the treatment of type 1 diabetes 47th annual meeting of Japan Diabetes

Society May 13-15 2004 116. Matsumoto S, Okitsu T, Iwanaga Y, et al Assurance of safety and reliability by

institutional GMP for clinical islet isolation. 3rd Annual meeting Japan Society of Tissue Transplantation August 28th 2004, Kanagawa Japan

117. Okitsu T, Matsumoto S, Iwanaga Y, et al Clinical islet transplantation in Japan based

on Edmonton protocol 3rd Annual meeting Japan Society of Tissue Transplantation August

28th 2004, Kanagawa Japan

118. Iwanaga Y, Matsumoto S, et al. Islet Storage without freezing by green tea polyphenol 3rd Annual meeting Japan Society of Tissue Transplantation August 28 th 2004, Kanagawa Japan

119. Yonekawa Y, Okitsu T, Matsumoto S et al. Four islet isolation and two islet

transplantation using non-heart-beating donor 3rd Annual meeting Japan Society of Tissue Transplantation August 28th 2004, Kanagawa Japan

120. Noguchi H, Matsumoto S, Okitsu T et al. PDX-1 Protein Containing Its Own Antennapedia-Like Protein Transduction Domain Can Transduce Pancreatic Duct Cells 3rd

Annual meeting Japan Society of Tissue Transplantation August 28 th 2004, Kanagawa Japan 121. Matsumoto S, Okitsu T, Iwanaga Yet al Living donor and non-heart-beating donor islet

transplantation 40th Annual meeting of The Japan Society for Transplantation September 16-18 2004, Okayama, Japan

122. Noguchi H, Matsumoto S, Okitsu T et al Transduction towards pancreatic beta cell by

PDX-1 protein transduction system 40th Annual meeting of The Japan Society for

Transplantation September 16-18 2004, Okayama, Japan

123. Okitsu T, Matsumoto S, Iwanaga Yet al. Safety and reliability for clinical islet transplantation by iGMP 40th Annual meeting of The Japan Society for Transplantation September 16-18 2004, Okayama, Japan

30

124. Iwanaga Y, Matsumoto S, Okitsu T et al. 3 cases of human islet isolation at the Kyoto University 40th Annual meeting of The Japan Society for Transplantation September 16-18

2004, Okayama, Japan

125. Iwanaga Y, Rilo H, Matsumoto S, et al. Pitfall for all-islet transplantation based on auto-islet transplantation 40th Annual meeting of The Japan Society for Transplantation September 16-18 2004, Okayama, Japan

126. Noguchi H, Matsumoto S et al. Mechanism of PDX-1 protein transduction system 40th

Annual meeting of The Japan Society for Transplantation September 16-18 2004, Okayama, Japan

127. Yonekawa Y, Okitsu T, Matsumoto S et al Importance of washing during islet isolation 40th Annual meeting of The Japan Society for Transplantation September 16-18 2004,

Okayama, Japan 128. Okitsu T, Matsumoto S, Iwanaga Y et al Islet Transplantation at the Kyoto University.

21st Century Symposium, April 14th 2005 Kyoto Japan

129. Noguchi H, Iwanaga Y, Matsumoto S et al Establishment of new induction method towards beta cell regeneration 21st Century Symposium, April 14th 2005 Kyoto Japan

130. Okitsu T, Matsumoto S, Iwanaga Y et al Islet Transplantation in Japan from non-heart-beating donor based on Edmonton Protocol. 105th Annual Meeting of Japan Surgical

Society May 11-13 2005, Nagoya Japan 131. Yonekawa Y, Matsumoto S, Okitsu T et al Establishment of Mouse Islet

Transplantation model in selective right lobe of liver. 105th Annual Meeting of Japan Surgical Society May 11-13 2005, Nagoya Japan

132. Matsumoto S, Okitsu T, Nagata H et al Islet Transplantation from non-heart-beating

donor for the treatment of type 1 diabetes. 48th Annual Meeting of Japan Diabetes Society

May 12-14 2005, Kobe, Japan

133. Noguchi H, Matsumoto S, Okitsu T et al Establishment of new induction method for beta cell transplantation. 48th Annual Meeting of Japan Diabetes Society May 12-14 2005, Kobe, Japan

134. Noguchi H, Okitsu T, Matsumoto S et al Activation of c-Jun NH2-terminal kinase and

influence of its inhibitor on islet transplantation. 22nd Bilio pancreatic physiology association June 25th 2005

135. Nagata H, Iwanaga Y, Matsumoto S et al Establishment of islet transplantation using non-heart-beating donor. 22nd Bilio pancreatic physiology association June 25th 2005

136. Yonekawa Y, Okitsu T, Matsumoto S et al Initiation of porcine islet isolation at our

own institute The 4th Meeting of Japan Society of Tissue Transplantation, August 27th 2005

Osaka, Japan

137. Nagata H, Iwanaga Y, Matsumoto S et al Establishment of pancreas procurement from non-heart-beating donor for successful clinical islet transplantation. The 4th Meeting of Japan Society of Tissue Transplantation, August 27th 2005 Osaka, Japan

31

138. Noguchi H, Iwanaga Y, Matsumoto S et al Establishment of clinical islet transplantation using non-heart-beating donor. The 4th Meeting of Japan Society of Tissue

Transplantation, August 27th 2005 Osaka, Japan

139. Matsumoto S, Iwanaga Y, Okitsu T et al Living donor islet transplantation for the treatment of severe diabetes. The 4th Meeting of Japan Society of Tissue Transplantation, August 27th 2005 Osaka, Japan

140. Okitsu T, Iwanaga Y, Matsumoto S et al Islet isolation from non-heart-beating donor

for clinical islet transplantation in Japan The 4th Meeting of Japan Society of Tissue Transplantation, August 27th 2005 Osaka, Japan

141. Iwanaga Y, Matsumoto S, Yonekawa Y et al Effect of green tea polyphenol for porcine islet cryopreservation. The 8th Annual Meeting of the Japan Society for Tissue

Engineering September 1st and 2nd 2005, Tokyo Japan 142. Matsumoto S, Okitsu T, Iwanaga Y et al. Fresh and cultured islet transplantation from

non-heart-beating donor. 38th Annual Meeting of Japan Society for Clinical Kidney Transplantation, January 26-28, 2006, Otsu, Japan

143. Hara M, Matsumoto S et al Coordination for islet transplantation at Fujita Health

University 38th Annual Meeting of Japan Society for Clinical Kidney Transplantation,

January 26-28, 2006, Otsu, Japan

144. Nagata H, Matsumoto S, Okitsu T et al. Successful islet transplantation from non-heart-beating donor with kidney transplantation surgeon. 38th Annual Meeting of Japan Society for Clinical Kidney Transplantation, January 26-28, 2006, Otsu, Japan

145. Matsumoto S, Okitsu T, Iwanaga Y et al. Fresh and Cultured islet transplantation from

non-heart-beating donor. 33rd Annual Meeting of Japan Pancreas and Islet Transplantation Association March 18-20 2006, Chiba Japan

146. Okitsu T, Iwanaga Y, Matsumoto S et al. How to procure pancreas from non-heart-beating donor. 33rd Annual Meeting of Japan Pancreas and Islet Transplantation

Association March 18-20 2006, Chiba Japan 147. Matsumoto S, et al. Islet transplantation in USA based on Japanese islet criteria. 34 th

Meeting of Japan Pancreas and Islet Transplantation Association, March 30 2007, Osaka Japan

148. Matsumoto S, et al. Estimation of Donor Usability for Islet Transplantation in the United

States with the Kyoto Islet Isolation Method. The 34th Meeting of Japan Society of Organ

Biology & Preservation, November 18 2007, Sapporo, Japan

149. Matsumoto S, et al. SUITO index for evaluation of efficacy of single donor islet transplantation. The 34th Meeting of Japan Society of Organ Biology & Preservation, November 18 2007, Sapporo, Japan

Invited Talk

2001

1. Matsumoto S. University of Cincinnati: The Remarkable Success of Two-Layer Pancreas

Preservation. April 2001, Cincinnati

32

2. Matsumoto S. University of Nebraska: The Remarkable Success of Two-Layer Pancreas Preservation. April 2001, Omaha

3. Matsumoto S. University of Miami: The Remarkable Success of Two-Layer Pancreas

Preservation. June 2001, Miami

2002

4. Matsumoto S. Benaroya Research Institute: Islet Isolation and Preservation. February 27th 2002, Seattle

5. Matsumoto S. UCSF: Current progress of human islet isolation, April 11th 2002 San

Francisco

6. Matsumoto S. University of Hawaii: Current progress of human islet isolation, June 7 th 2002,

Hawaii 7. Matsumoto S. UCLA (City of Hope Institute): Two-layer method of pancreas preservation

prior to islet isolation. September 9th 2002 Los Angeles

8. Matsumoto S. 14th Hokkaido Symposium on Transfusion Medicine. Current overview of Tissue Banking in the United States, October 18th 2002, Sapporo

9. Matsumoto S. Waseda University: Perfluorocarbon for organ preservation. December 2002, Tokyo

2003

10. Matsumoto S. Clinical application of perfluorocarbons for organ preservation. IX

international symposium on blood substitute 2003 March 3-5, Tokyo Japan

11. Matsumoto S. Kyoto National Hospital. Islet Transplantation Update December 16 th 2003, Kyoto

2004

12. Matsumoto S. Nagoya 2nd Red Cross Hospital. Islet Transplantation Update January 8th

2004, Nagoya Japan 13. Matsumoto S. Fujita Health Hospital. Islet Transplantation for sever diabetes mellitus.

February 26th 2004, Aichi Japan

14. Matsumoto S. Current topics of islet transplantation and future. 31st annual meeting of Japan Pancreas and islet transplantation March 26, 27 04, Okayama Japan

15. Matsumoto S：Current Status of Islet Transplantation: The104th meeting of the Japan Surgical Society Annual Meeting April 7th 04, Osaka Japan

16. Matsumoto S Islet Transplantation for curing Type 1 Diabetes Current status in the world

and Japan. Gifu-Aichi Tsubomi Meeting May 8th 2004, Nagoya Japan 17. Matsumoto S Successful islet transplantation from non-heart beating donor in Japan. The

15th international symposium on molecular biology of hematopoiesis. 2004 May 15-19

18. Matsumoto S Islet Cell Transplantation 1st Congress of Promotion Fukui Organ Transplantation Association May 25th 2004, Fukui Japan

33

19. Matsumoto S Islet Cell Transplantation for the treatment of severe diabetes. The 19 th Congress of Diabetes Foot Disease, June 26th 04, Tokyo, Japan

20. Matsumoto S Islet Transplantation for type 1 diabetes 20th Meeting of Hokuriku

Endocrinology and Metabolism July 30th 2004 21. Matsumoto S Islet transplantation for the treatment of type 1 diabetes 6th Seminar Osaka

University Future Medicine August 25th 2004, Osaka Japan

22. Matsumoto S Islet Transplantation Update –The latest treatment for type 1 diabetes. Annual congress of Kyoto Internal Medicine, October 16th 2004, Kyoto Japan

23. Matsumoto S Islet Transplantation for the treatment of diabetes. 28th Kyoto University Seminar in Hyogo, October 21st 2004, Kobe Japan

24. Matsumoto S Basic science and clinical application of islet transplantation Kinki Diabetes

Meeting December 11th 2004, Osaka, Japan

2005

25. Matsumoto S Current Status of Islet Transplantation 35th South Osaka Diabetes Seminar February 12th 2005, Osaka Japan

26. Matsumoto S Current Tops of Islet Transplantation 27th Congress of Diabetes Therapy,

February 26th 05, Osaka, Japan 27. Matsumoto S Islet Transplantation at the Kyoto University 9th Workshop Tissue

Engineering and Regenerative Medicine, March 12th 05 Kobe, Japan

28. Matsumoto S Special Report: World First Success of Living Donor Islet Transplantation. 33rd Annual Meeting of The Japan Society for Pancreas and Islet Transplantation, Chiba, Japan March 19th 05

29. Matsumoto S Current topics of islet transplantation 12th Annual Meeting of Cell Therapy

April 12th 05 30. Matsumoto S Islet Transplantation UPDATE 34th Chikugo-Saga Diabetes Meeting April

15th 2005, Saga Japan

31. Matsumoto S Current Status of Islet Transplantation 18th Meeting of West Mikawa Diabetes Society April 21st 2005, Aichi Japan

32. Matsumoto S Islet Transplantation from Non-heart-beating donor and living donor. The 48th Annual Congress of Japan Diabetes Society, May 12-14, 2005, Kobe, Japan

33. Matsumoto S Current Status of Islet Transplantation 26th Organ Transplantation Meeting

May 16th 2005

34. Matsumoto S. Puget Sound Blood Center. Islet Transplantation in Japan. May 19th 2005,

Seattle 35. Matsumoto S Clinical results of islet transplantation – including safety of living donor 53rd

Annual Congress of Japan Transfusion Society May 26th 05, Chiba Japan

34

36. Matsumoto S Islet Transplantation UPDATE 6th Congress of The society of Therapy for Diabetes and Lifestyle-Related Illnesses May 28th 05, Kyoto Japan

37. Matsumoto S Current Status of Islet Transplantation in Japan 18th Annual Congress of

Japan Association of Cerebral Resuscitation & Brain Death. June 3rd 05, Nagoya, Japan 38. Matsumoto S. Islet transplantation at Kyoto University. University of Miami June 30 th 2005,

Miami

39. Matsumoto S Islet Transplantation Congress of the Fukui Red Cross Hospital September 2nd 2005, Fukui Japan

40. Matsumoto S Aiming for Improvement of Islet Transplantation. 11th Forum for Diabetes Treatment, October 1st 2005, Tokyo Japan

41. Matsumoto S Current Status of Islet Transplantation. The 43rd Meeting of Japan Diabetes

Society Division of Chushikoku. November 12th 2005

42. Matsumoto S Living donor islet transplantation The 32nd meeting of Japan Low

Temperature Medicine, November 25th 2005 Tsukuba, Japan 43. Matsumoto S Islet Transplantation Working Group The 8th meeting of Kinki Pancreas

Transplantation Society, November 26th 2005, Osaka, Japan

44. Matsumoto S. Living donor islet transplantation – The first success and challenge Grand Rounds Lecture Baylor University, November 30th 2005, Dallas

45. Matsumoto S. Islet transplantation Project at Kyoto University. Road Map to Cure for Type 1 Diabetes. Baylor University, November 30th 2005, Dallas

46. Matsumoto S. Pancreatic islet cell transplantation from a living donor – The world’s first

case. The Fort Worth club, December 1st 2005, Fort Worth

2006

47. Matsumoto S Islet Transplantation –Road map for curing type 1 diabetes. The 10th Meeting of Japan IDDM network Forum, January 28th 2006, Tokyo, Japan

48. Matsumoto S New treatment for diabetes: Islet Transplantation The 39th Evening conference of Nagoya Diabetes Society, January 26th 2006, Nagoya Japan

49. Matsumoto S Type 1 diabetes and Islet Transplantation The 7th West Tokyo EBM diabetes

treatment society. February 4th 2006

50. Matsumoto S Islet Transplantation Update, 2nd Meeting of Tokushima post operation

society, February 7th 2006, Tokushima Japan 51. Matsumoto S. Islet transplantation in Kyoto including live donor. Baylor Research Institute

February 16, 2006, Dallas

52. Matsumoto S. Islet transplantation Project for Diabetes at Kyoto University. Franco-Japanese Translational Research Initiative (1st) February 25, 2006, Kyoto

53. Matsumoto S. Islet transplantation current status and goal. Kamogawa Juku March 4th, 2006, Kyoto

35

54. Matsumoto S Islet transplantation in Japan The 4th Meeting of Japan Regenerative Medicine Society, March 8th 2006, Osaka Japan

55. Matsumoto S Islet Transplantation current status and future, The 2nd meeting of Future

treatment of Lifestyle related illness. March 11th 2006, Kyoto Japan 56. Matsumoto S. Current topics of Islet Transplantation The 4th Shinshu Diabetes Society,

March 14th 2006, Matsumoto Japan

57. Matsumoto S. Perspective of living donor islet transplantation The 33rd meeting of Japan Pancreas and Islet Transplantation Association, March 18th 2006, Chiba Japan

58. Matsumoto S. Living donor islet transplantation. World First Success. Chung Gung Memorial Hospital March 26th, 2006, Taipei

59. Matsumoto S. Islet Transplantation-Kyoto Experiences 27th Annual Meeting of Endocrine

Society and Diabetes Association of the R.O.C 2006 March 25-26, Taipei

60. Matsumoto S Living donor islet transplantation for the treatment of pancreatectomy in

child, the world first successful case. The 106th meeting of Japan Surgical Society, March 29-31 2006, Tokyo Japan

61. Matsumoto S Islet Transplantation UPDATE, Sapporo Clinical Diabetes Association April 8th 2006, Sapporo Japan

62. Matsumoto S Current Topics of Islet Transplantation The 34th meeting of Kinki clinical

diabetes association. April 15th 2006, Osaka Japan

63. Matsumoto S Islet transplantation for type 1 diabetes The 109th meeting of Japan Pediatric

Society April 23rd 2006, Kanazawa Japan 64. Matsumoto S Preparation of islet transplantation at Fujita Health University. Gifu-Aichi

Tsubomi meeting April 30th 2006, Nagoya Japan

65. Matsumoto S. Pancreatic islet cell transplantation using NHBDs. The third international meeting on transplantation from non-heart-beating donors. UK London 2006 May 11th.

66. Matsumoto S. Islet transplantation in Japan. Korean Diabetes Association 19th Spring Meeting, Korea Seoul,2006 May 13th

67. Matsumoto S. Islet cell transplantation for the treatment of Diabetes. Peru Arequipa 2006

May 18th

68. Matsumoto S. Transplantes de celulas para el tratamiento de la diabetes. Peru Lima 2006

May 19th. 69. Matsumoto S. Islet cell transplantation for the treatment of Diabetes. Peru Ica 2006 May

20th

70. Matsumoto S Islet Transplantation, Current Status and Future The 49th Meeting of The Japan Diabetes Society, May 25th Tokyo, Japan

71. Matsumoto S Islet Transplantation Update, Hiroshima Tsubomi Meeting May 28th 2006

36

72. Matsumoto S Islet Transplantation Update The 39th meeting of the West Tokyo Clinical Diabetes Association June 24th 2006

73. Matsumoto S Islet Transplantation, Current Status and Future the 42nd meeting of Himeji

Medical Society June 23rd 2006 74. Matsumoto S Islet Transplantation Update, The 9th meeting of the Hokkaido molecular

diabetes association, June 28th 2006, Sapporo Japan

75. Matsumoto S Islet Transplantation-current status. The 45th meeting of Saitama Diabetes Association, July 1st 2006, Saitama Japan

76. Matsumoto S. Islet transplantation for treating diabetes in Japan. Chinese Dialysis and Transplant Association. July 7th 2006, Shanghai China

77. Matsumoto S. Islet transplantation in Japan. 4th Catholic International Stem Cell

Symposium July 14th 2006, Seoul

78. Matsumoto S Islet Transplantation Update The 47th the Latest Medicine Seminar, First

Department of Medicine Kyushu University July 25th 2006, Fukuoka Japan 79. Matsumoto S Effect of living donor islet transplantation for IDDM. The 42nd meeting of

The Japan Society of Transplantation September 9th 2006, Chiba Japan

80. Matsumoto S Islet Transplantation Update The 20th meeting of the Okayama Multi-organ failure association September 9th 2006 Okayama Japan

81. Matsumoto S Frontline of diabetes treatment; islet transplantation The 11th meeting of Japan Academy of Diabetes Education and Nursing, September 16 th 2006, Kyoto Japan

82. Matsumoto S Islet transplantation The 23rd meeting of Stem Cell Forum Tokyo, Japan,

September 21st 2006

83. Matsumoto S Islet Transplantation, The 8th meeting of Fukui Diabetes Association,

September 22nd 2006, Fukui Japan 84. Matsumoto S Progress of pancreas and islet transplantation, 41st Advances of Diabetology

September 29th 2006, Sapporo Japan

85. Matsumoto S Islet Transplantation Current Status and Future, Otsuka Pharma, October 5 th 2006, Naruto Japan

86. Matsumoto S Islet transplantation current status and future, The University of Tokyo November 7th 2006, Tokyo Japan

87. Matsumoto S Islet transplantation current status and perspective. The 9th Kinki pancreas

transplantation association, December 2nd 2006, Osaka Japan

88. Matsumoto S Pancreas and Islet transplantation. Center of Excellence Open Seminar,

Nagoya Japan, December 9th 2006 2007

89. Matsumoto S. Update of current status. Kobe University Department of Surgery Annual Meeting. January 19 2007, Kobe Japan

37

90. Matsumoto S. Research and Development of Cell Isolation and Preservation for Islet Transplantation, Annual Meeting of Foundation for Biomedical Research and Innovation,

February 16th, Osaka Japan

91. Matsumoto S. Islet Transplantation Current Status and Future Plan, Transplant Conference, Baylor All Saints March 1st 2007

92. Matsumoto S. Islet Transplantation as a model of translational research. Japan Ministry of Health, Labour and Welfare, March 9th 2007

93. Matsumoto S. Islet Transplantation. Presentation for Novartis Pharma March 13th 2007,

Fort Worth

94. Matsumoto S. Islet Cell Transplantation. Diabetes Research Leadership Forum April 21st

2007 95. Matsumoto S. Strategy & Vision for Diabetes at Baylor. Diabetes Research Leadership

Forum April 21st 2007

96. Matsumoto S. Diabetes and Islet Cell Transplantation. Fort-Worth Japanese Community Meeting May 20th 2007, Fort-Worth

97. Matsumoto S. Clinical Islet Transplantation Update. The 5th Catholic International Stem Cell Symposium, June 1st Seoul Korea

98. Matsumoto S. Islet Transplantation Frontline 109th Endocrinology Seminar July 7th 2007,

Tokyo, Japan

99. Matsumoto S. Islet Transplantation. The University of Tokyo Seminar, July 7th 2007, Tokyo

Japan 100. Matsumoto S. Islet Transplantation. 17th World Congress of the International

Association of Surgeons, Gastroenterologists and Oncologists September 8th 2007, Bucharest Romania

101. Matsumoto S. Islet Transplantation Update. Tohoku Transplantation Congress, Sendai

Japan September 22 2007

102. Matsumoto S. Update on Islet Cell Transplantation, Immunology Seminar, Baylor

Sammons Cancer Center, September 28 2007 103. Matsumoto S. Islet Transplantation. Open Seminar, Baylor Research Institute,

November 4th 2007

104. Matsumoto S. Development and Application of Islet Transplantation. 2nd Symposium of Medical Renovation from the Site. November 10th 07 Tokyo, Japan

105. Matsumoto S. Islet Transplantation Update. Japan Ministry of Health, Labour and Welfare, November 11th 2007

106. Matsumoto S Islet Transplantation Current Status and future direction, Cell Therapy

Sub-committee Committee for the Development of Health and Medicine November 12 th 07,

Tokyo, Japan

2008

38

107. Matsumoto S Islet Transplantation for the treatment of Diabetes Update, Research on Focus, Fort Worth, January 23 08, Fort Worth TX

108. Matsumoto S Islet Cell Transplantation Update, Research on Focus, February 19 th,

Dallas Tx 109. Matsumoto S Islet cell transplantation and regenerative medicine, current status and

future of the world. International Comparison of regenerative and transplantation medicine, March 5th 08, Kobe Japan.

110. Matsumoto S Islet Transplantation an Update. Taipei International Transplantation

Forum April 25th 2008, Taipei, ROC

111. Matsumoto S Islet Transplantation for the treatment of Diabetes. 56th Annual Meeting of

The Japan Society of Transfusion Medicine and Cell Therapy April 26 th Fukuoka, Japan 112. Matsumoto S Islet Transplantation with Non-heart-beating, living and brain dead donors.

108th Annual meeting of Japan Surgical Society, May 16th 2008, Nagasaki Japan

113. Matsumoto S Islet Transplantation- Strategy from Translational Research to Clinical Treatment. Annual Meeting of Kenko-Iryo Kaihatsukiko, May 20th 2008, Tokyo Japan

114. Matsumoto S Pancreatic Islet Transplantation for the Treatment Type 1 Diabetes, 51st Annual Meeting of Japan Diabetes Society, May 23rd 2008, Tokyo Japan

115. Matsumoto S Establishment for Islet Transplantation Annual Meeting of Japan IDDM

network, May 25th 2008, Tokyo Japan

116. Matsumoto S, Update of Islet Transplantation at Baylor and Bio-Artificial Islet Project.

Invited Talk at Otsuka Pharmaceutical Company. August 1st 2008, Tokyo Japan 117. Matsumoto S, Islet Transplantation 2nd Naruto Conference October 15th 2008

Tokushima Japan

118. Matsumoto S. Why do we do the things we do in the islet cell transplantation. Monthly Transplant Conference, Baylor All Saints Medical Center December 4 th 2008

2009

119. Matsumoto S. Islet transplantation: Issues toward the standard therapy. 36 th Japan

Pancreas and Islet Transplantation Society. February 28 2009. Fukuoka

120. Matsumoto S. Islet transplantation: Strategy for standard therapy from translational

research. Special symposium at The Institute for Health Medicine Development. March 15 2009. Tokyo

121. Matsumoto S. Islet cell transplantation and perspective at the Baylor Research Institute. 10th biannual Cell Transplant Society and the 36th annual meeting of Japan Society for

Organ Preservation and Medical Biology, April 20-21 2009. Okayama 122. Matsumoto S. Islet isolation technology and transplantation for the treatment of diabetes.

MetroCon 2009, August 17th 2009, Arlington TX

39

123. Matsumoto S. Clinical experience of islet transplantation. American Association of Blood Bank. 62nd annual meeting, October 24-27 2009 New Orleans, LA

40

Patent Application

1. US Patent 10/171093

Inventors： Shinichi Matsumoto, Theodore Rigley, R. Brian Stevens

Name of invention： Method and device for preserving organs for transplantation

Submitted： Shinichi Matsumoto, Theodore Rigley, R. Brian Stevens

Date of submission：2002.7.12

2. Japanese Patent：2003-377321

Inventors： Shinichi Matsumoto, Kazuo Umihira

Name of invention：Apparatus for maintain temperature

Submitted： Shinichi Matsumoto, Kazuo Umihira

Date of submission：2003.11.6

3. Japanese Patent：2004-370732

Inventors： Shinichi Matsumoto, Hiromi Wada

Name of invention： Solution for organ and tissue preservation

Submitted： Kyoto University

Date of submission： 2004.12.22

4. Japanese Patent：2005-211228

Inventors： Shinichi Matsumoto, Hirofumi Noguchi, Hiromi Wada

Name of Invention： Method for islet cell isolation

Submitted： Kyoto University

Date of submission：2005.7.21

Based patent submission：2004-370732

5. US Patent 11/056,897

Inventors： Shinichi Matsumoto, Bernhard Hering

Name of invention： Methods and materials for isolating isogenic islet cells

Submitted： Shinichi Matsumoto, Bernhard Hering

Date of submission： 2005.2.11

Technique for Harvesting Processing Islet Cell for Transplantation

U/M Docket#Z01207 6. US Patent 61/022,740

Improvements in pancreatic islet isolation and transplantation Inventor: Shinichi Matsumoto

Serial No. 61/022,740. Date of file 1/22/2008 Sponsor: Baylor Research Institute

41

Research Support

Ongoing Research Support

1. Roche-Supported Research (PI): Isolation of high quality islets from young donor pancreata using Liberase MTF, 2010-2011

2. Juvenile Diabetes Research Foundation (Co PI): Withaferin for islet transplantation, 2010-2011

Completed Research Support 1. Otsuka Pharmaceutical Company (PI): Innovation of effective islet isolation method for

next generation islet transplantation. Role PI, Developing new islet isolation method, 2007-2009

2. Juvenile Diabetes Research Foundation (Co PI): Improving islet isolation by pancreas

preservation with JNK inhibitor 2008-2009 3. Japan IDDM net work, research grant (Consultant): Immunological tolerance for islet

transplantation. 4. Japan Society for the Promotion of Science, Grants- in-Aid for Scientific Research (S)

4/1/2006-3/31/2007 Establishment of the treatment for insulin dependent diabetes mellitus

by the living donor islet transplantation with regenerative medicine Role: PI, Establishing living donor islet transplantation

5. Foundation for Biomedical Research and Innovation (commercia l viability grant) 4/1/2005-3/31/2007 Research and development of cell separation and storage. Role: PI, Developing islet isolation and storage method

6. Ministry of Education, Culture, Sports, Science and Technology (Innovation grant) 4/1/2006-3/31-2007. Assessment of newly developed protein peptide transduction

technology for the improvement of transplanted islet cell engraftment Role: PI, Introducing protein transduction technology for islet transplantation

7. Ministry of Health, Labour and Welfare (Research Grant) 4/1/2004-3/31/2007. Quality

control and banking of isolated islets for clinical islet transplantation. Role: Co-PI, Establishing islet banking

8. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research (A) 4/1/2006-3/31/2007 Super thin membrane made by bi-affinity large molecule for islet encapsulation. Role: Co-PI, Establishing new islet encapsulation technique

9. Ministry of Education, Culture, Sports, Science and Technology (Innovation grant) 4/1/2004-3/31/2006 Protein transduction technology for beta-cell induction and its clinical

application Role: PI, Introducing protein transduction technology for beta cell regeneration 10. Japan Society for the Promotion of Science, Grants- in-Aid for Scientific Research (B)

4/1/2003-3/31/2005 Islet transplantation from partial living donor pancreas for the treatment

of type 1 diabetes. Role: PI, Initiating living donor islet transplantation 11. Japan Society for the Promotion of Science, Grants- in-Aid for Scientific Research (B)

4/1/2004-3/31/2006 Green tea polyphenol for preservation of islet and improvement of islet engraftment. Role: Co-PI, Examining the effect of Green tea polyphenol for islet preservation and transplantation