Cutaneous SCC: Metastases with a predilection for lungs 6 years after excision of the primary tumour
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Abstracts/Lung Cancer 13 (1995) 81-104 87 Reliability of commercially available immunocytochemical markers for identilication of neuraendocrine differentiation in bronchoscopic biopsies of bronchial carcinoma Gosney JR. &,s.ey MA. Lye M. But, SA (‘mu De,,, ci/~orb&~i: Duncon B”,W”p. RcJdL,“erp*,, (Co li”.Yp, Daulhv Smw. Lwrpoo, I.7 XSH Thorax lY95.50’116-2” Clinical assessment Staging of non-small cell lung cancer (NSCLC): Progress and limitations of imaging methods Guckel C. Stulz P. Bolhger CT. hsrrrur jur Drogn Rodrologie, A’an~oonssp,rol Bose/, Un/versrlo:~kbnlken. Perersgmben 4. CH-4031 Base/ Aktuel Padiol 1995.5:79-86. Bockgmund- Although neurocndocnnc ddTcrcnuillmn occurs qurlc commonly rn non-small cell brcmchral mahgnancres. as brologrcal srgnilicance and rmplrcalmns for management reman unccnarn Dctermmmg lhese Iacts rcqwres rts rccogn,,,on early. rdcall) a, diagnoses. whrch IS usually made on lrssue from bronchoscop). but the best means of its dctcctron m such n~lcr~al IS unclear A prospecu\c comparatwe study was paformcd of IO commcrcrall~ a\arlablc anusera to a serves ol markers of ncumcndocrmc ddTcrcnuacmn. 10 lest lhcrr eficxy when apphcd IO fibrcoplx bronchoscopy bmpr) spccmrcns Alelhodr - Exprcssro” of chromogramn A. qnap,oph!s,n. ncurone- spccUiccn&sc. pmlcmgcnepmduct Y 5. Ihc BB wen,~mcofcrcat~nc kmase. gastrin relcasrng pcptrdc. adrcnocorlrcotrophrc hormone. calcrtomn. calcrlonm gcnc rclatcd peptrdc. and kwmc cnkcphahn \,as sought by mm,unolabcllmg of bronchoscoprc bmpn ussuc from 81 primary bmnchral carcinomas. 22 ofthcm or small cell t?ic Resullr . Only synaptophystn and chromogranm were scnsrtr\c and specdic enough for nwmcndocnnc ddTercntratmn to drscnmmalc bcl~ccn small cell and non-small cell lesmns. uhcrcas pmtcm gene product 9 5 and creatine kinase were nerthcr parlrcularly scnsrtwc nor specdic and ncurone-speclIic enolase actually labcllcd more non-small cell ,“rno”rs than small cell ksmw Oflhe live soxmry producls soughL only gannn releasmg pepudc was dcfccrable rn lust one turnour Three squamous and two morpholagrcally undillcrcnlratcd lunwurs rmnvmolabcllcd for synaptophysm and chramogranm. almost ccnaml? mdrcatmg ncuro- cndocrme dr!Tcrenctalmn m the absence of small cell morph&g\ (hnclu.rronr - Of Ihc markers studied. onl? r?napmph!rrn and chromogranrn wcrc sullicmtly specrfic and scnsmrc for ncurccrdocrme ddTcrcntralmn IO)ustlCy their mcIuslon mans panel ofanllbcdlcs used I” rts daccuon I” trssw oblamcd at fibrcoplrc bronchoscop> Histogenesir of carcinoma of the lung Cotin B. Bmmpron Hospital. Sydney Shecl, London SW3 6NP. Radio1 Oncd 1994;28:261-5. A hyperplasra _ dysplasia - neoplasia sequence is well documented in the lungs The premalignant changes are wndcspread and there is a hrgh incrdcnce of double or second lung cance.rs: 4% synchronous and 6% metachronous. The padents most at risk of developing lung cancer are those who have had one in the past. These parents might therefore be worth following up panicularly frequently. Lung cancer hdlils many of the criteria necessary for a successful screening programme. Unfortunately the premalignant changes cannot be early eradicated there is no bmnchopulmonary equivalent of a uterine cane bropsy and screening for early invasive grmvths has not been shown to reduce mortality The hyperplasia - dysplasra _ neoplasia sequence is again encountered rn the periphery of the lung. particularly when (here IS ditise pulmonary Bhmsis. In thus condition there IS often hyperplasia of type II cells. sometimes accompanied by extension of bronchiolar epilhelium inlo adJacenl alveoli. squamous metaplasia and dysplasia The urncurs that develop m pulmonary fibrosis may be ofany type but adenccarcmoma IS parucularly well represented. Premabgnanf changes leadmg to the development of small cell carcmoma are not well recognwd Hyperplasia of bronchopulmonary neuroendocnne cells is described. sorncurnes m aswc~atmn with neuroendocrme neoplasms, whrch on occasron may be multifocal, but the neoplasrns concerned are carcmord tunwurs rather than small cell carcrnomas Association between gene alteration and drug sensitivity in humln lung carcinoma cell lines Mizushima Y , Kashii T , Kobayashi M. 1st Deporrrnenr of lnlernol Medmne, Tovamo Med~caNPhormaccrricaI Unrv 2630 Sue~tanr. Toyama 930-o/. Oncol Rep 1995;2:277%0 The association between gene alterations (K-ras, P53, N-myc) and drug raistarce (CDDP. CBDCA. MMC. Epi-ADM) was exanuned in 29 human lung carcmoma all lines using the invifrohflT assay. There was no significant diffcrencz in the IC,, values of four drugs between K-ras or P53 gene alterauon-positive and -negative groups However, two cell lines with N-myc amplification showed a higher resistance than those without N-myc arnpliiication to all four drugs. This preliminary study suggests that K-ras or P53 gene alteratron is probably not related to drug resistance. but N-myc might be Imaging methods, especially CT and for spccilic questions MRl. are an essentral parl of dragnosis and stagmg of non-small cell lung cancer. They are eITeclive methods for lhe detectron of unresectable turnours and word the necesrtty for further invasive examinations and explorative thoracotomies. The judgement of lymph node we by CT sulTers from a hmrted accuraq Nevertheless. it allows gurdcd broncho- scoprcal slagmg biopsres ofenlarged medrastinal lymph nodes (> l cm) and. Iherefore. a selective mdicabon of mcdiastmoropy CT scans of the thorax usually are extend& 10 the adrenal glands and the lrver 10 exclude metastasis Extrathorax scannmg beyond the uppcr abdomen and bone wintrgraphy should be restr~cwd to palrcnls wrth chmcal mdmalonorsymptoms Thecombrnedapplrcatronolrmagrng methods. bronchoscop). and mcdrastmoscop) prowdes bcttcr rlcctmn olsurgrcal candidates and hence reduces Ihe rate of unrcscctablc opcrabons lung camxr Nakano N. Oyama S. Kolake Y, Yasumitsu T . Deparrmenl of Surgge~, h’alronal Sanolortum. Ehrme Hosprtol. 366. Yokonowara. Shmenobu- cho, Onsen-gun. Ehtme 791-02. Jbn J MecJ Ultras& 1995,22:27-30. We evaluated the usefulness of ultrasonographic studres m the dragnow of pleural adhesmn before surgery in I20 patients wrth lung cancer Senritwlty, specilicity, and accuracy were 63%. 81%. and 72%. respectively, in the realtime diagnoses ofpleural adhesmn m 58 parents with ultrawrwgraphic lindings indicative oflung tumor: they were 3 I% 80%. and 68%. respectively m 62 patrents whose ultrasonographrc lindrnas were not indicative of lungtumor Sensitivity was signdicantly hrgheirn parents with ultrasono~raphrc Iindmgs indic&e of lung tumor than rn those with negative lindmgs cp>o 05). Our results indicate that ultrasonographrc diagnosis of pleural adhesmn IS feasible? its specdicity was about 80%. whether lung tumor was present or not. Lung carxer complicating pregnancy: Case report and review of literature Van Winter I T . Wilkowske MA, Shaw EG, Ogbum PL Jr, Pritchard DI. Department ofObsteb~cdGvneco/wv, Mwo Clinic/&h&e,: 200 First S&d SW Riches&,: MN jS905. t&y0 &in Pmc 1995;70:384-7. Lung cancer during pregnancy is rare. Herein we describe a case of metmatic cancer of the lung rn a 36year-old pregnant patient whose initial mmplamt was pain in the kfl thigh. Management of this neoplasm during pregnancy depends on the gestational age of the fetus and the potential operability of the tumor. Surgical, chemotherapeutic, and radiation management considerations are discussed. Cutaneous XC: Metastases with a predikctio” for lungs 6years after excision of the primary tumour Panayrotou BN. Aravindan N. Smha SK, Ryact K Deportment 01 Clrnrcol Phormocologv, Ci@ General Hosprtal, Stoke-on-Trenl S-T4 6QG Br J Clin Pratt 1995.49 107-S An SO-year-old woman developed an ulcerated. moderately ddferenliated squamws cell carcuwna (SCC) on the lower leg. Despite local excismn and radrolherapy, the parent presented 6 years later with multrple lung rnerastases whrch were histologically mdistingurshable from the orrginal skin turnour There was no evidence of metaslases to lymph nodcs or other vwxra Preoperative work-up for primary bronchogenic cancer Carette MF. Bawl M. Lehreton C. Chooier I. Boudehene F. Wallavs C et al Servtce de Rodtologte. Hoprrol Tenon. 4, RUP de lo Ch,ne, F 75020 Pans Feud1 Radio1 1995;35:26-38. We recall the I987 lungcarcinoma TNM classrfica~~on, and imagng powbihties of exploration of local IT), regional (N) and metastadc extension Criteria of mvolvement for each method are studred: the sensitivrty and specificrty of these criteria are diwrrsed. Computed
Transcript of Cutaneous SCC: Metastases with a predilection for lungs 6 years after excision of the primary tumour
Abstracts/Lung Cancer 13 (1995) 81-104 87
Reliability of commercially available immunocytochemical markers for identilication of neuraendocrine differentiation in
bronchoscopic biopsies of bronchial carcinoma Gosney JR. &,s.ey MA. Lye M. But, SA (‘mu De,,, ci/~orb&~i: Duncon B”,W”p. RcJdL,“erp*,, (Co li”.Yp, Daulhv Smw. Lwrpoo, I.7 XSH Thorax lY95.50’116-2”
Clinical assessment
Staging of non-small cell lung cancer (NSCLC): Progress and limitations of imaging methods Guckel C. Stulz P. Bolhger CT. hsrrrur jur Drogn Rodrologie,
A’an~oonssp,rol Bose/, Un/versrlo:~kbnlken. Perersgmben 4. CH-4031
Base/ Aktuel Padiol 1995.5:79-86.
Bockgmund- Although neurocndocnnc ddTcrcnuillmn occurs qurlc commonly rn non-small cell brcmchral mahgnancres. as brologrcal srgnilicance and rmplrcalmns for management reman unccnarn Dctermmmg lhese Iacts rcqwres rts rccogn,,,on early. rdcall) a, diagnoses. whrch IS usually made on lrssue from bronchoscop). but the best means of its dctcctron m such n~lcr~al IS unclear A prospecu\c comparatwe study was paformcd of IO commcrcrall~ a\arlablc anusera to a serves ol markers of ncumcndocrmc ddTcrcnuacmn. 10 lest lhcrr eficxy when apphcd IO fibrcoplx bronchoscopy bmpr) spccmrcns Alelhodr - Exprcssro” of chromogramn A. qnap,oph!s,n. ncurone- spccUiccn&sc. pmlcmgcnepmduct Y 5. Ihc BB wen,~mcofcrcat~nc kmase. gastrin relcasrng pcptrdc. adrcnocorlrcotrophrc hormone. calcrtomn. calcrlonm gcnc rclatcd peptrdc. and kwmc cnkcphahn \,as sought by mm,unolabcllmg of bronchoscoprc bmpn ussuc from 81 primary bmnchral carcinomas. 22 ofthcm or small cell t?ic Resullr .
Only synaptophystn and chromogranm were scnsrtr\c and specdic enough for nwmcndocnnc ddTercntratmn to drscnmmalc bcl~ccn small cell and non-small cell lesmns. uhcrcas pmtcm gene product 9 5 and creatine kinase were nerthcr parlrcularly scnsrtwc nor specdic and ncurone-speclIic enolase actually labcllcd more non-small cell ,“rno”rs than small cell ksmw Oflhe live soxmry producls soughL only gannn releasmg pepudc was dcfccrable rn lust one turnour Three squamous and two morpholagrcally undillcrcnlratcd lunwurs rmnvmolabcllcd for synaptophysm and chramogranm. almost ccnaml? mdrcatmg ncuro- cndocrme dr!Tcrenctalmn m the absence of small cell morph&g\ (hnclu.rronr - Of Ihc markers studied. onl? r?napmph!rrn and chromogranrn wcrc sullicmtly specrfic and scnsmrc for ncurccrdocrme ddTcrcntralmn IO )ustlCy their mcIuslon mans panel ofanllbcdlcs used I” rts daccuon I” trssw oblamcd at fibrcoplrc bronchoscop>
Histogenesir of carcinoma of the lung Cotin B. Bmmpron Hospital. Sydney Shecl, London SW3 6NP. Radio1 Oncd 1994;28:261-5.
A hyperplasra _ dysplasia - neoplasia sequence is well documented in the lungs The premalignant changes are wndcspread and there is a hrgh incrdcnce of double or second lung cance.rs: 4% synchronous and 6% metachronous. The padents most at risk of developing lung cancer are those who have had one in the past. These parents might therefore be worth following up panicularly frequently. Lung cancer hdlils many of the criteria necessary for a successful screening programme. Unfortunately the premalignant changes cannot be early eradicated there is no bmnchopulmonary equivalent of a uterine cane bropsy and screening for early invasive grmvths has not been shown to reduce mortality The hyperplasia - dysplasra _ neoplasia sequence is again encountered rn the periphery of the lung. particularly when (here IS ditise pulmonary Bhmsis. In thus condition there IS often hyperplasia of type II cells. sometimes accompanied by extension of bronchiolar epilhelium inlo adJacenl alveoli. squamous metaplasia and dysplasia The urncurs that develop m pulmonary fibrosis may be ofany type but adenccarcmoma IS parucularly well represented. Premabgnanf changes leadmg to the development of small cell carcmoma are not well recognwd Hyperplasia of bronchopulmonary neuroendocnne cells is described. sorncurnes m aswc~atmn with neuroendocrme neoplasms, whrch on occasron may be multifocal, but the neoplasrns concerned are carcmord tunwurs rather than small cell carcrnomas
Association between gene alteration and drug sensitivity in humln lung carcinoma cell lines Mizushima Y, Kashii T , Kobayashi M. 1st Deporrrnenr of lnlernol Medmne, Tovamo Med~caNPhormaccrricaI Unrv 2630 Sue~tanr.
Toyama 930-o/. Oncol Rep 1995;2:277%0 The association between gene alterations (K-ras, P53, N-myc) and
drug raistarce (CDDP. CBDCA. MMC. Epi-ADM) was exanuned in 29 human lung carcmoma all lines using the invifrohflT assay. There was no significant diffcrencz in the IC,, values of four drugs between K-ras or P53 gene alterauon-positive and -negative groups However, two cell lines with N-myc amplification showed a higher resistance than those without N-myc arnpliiication to all four drugs. This preliminary study suggests that K-ras or P53 gene alteratron is probably not related to drug resistance. but N-myc might be
Imaging methods, especially CT and for spccilic questions MRl. are an essentral parl of dragnosis and stagmg of non-small cell lung cancer. They are eITeclive methods for lhe detectron of unresectable turnours and word the necesrtty for further invasive examinations and explorative thoracotomies. The judgement of lymph node we by CT sulTers from a hmrted accuraq Nevertheless. it allows gurdcd broncho- scoprcal slagmg biopsres ofenlarged medrastinal lymph nodes (> l cm) and. Iherefore. a selective mdicabon of mcdiastmoropy CT scans of the thorax usually are extend& 10 the adrenal glands and the lrver 10 exclude metastasis Extrathorax scannmg beyond the uppcr abdomen and bone wintrgraphy should be restr~cwd to palrcnls wrth chmcal mdmalonorsymptoms Thecombrnedapplrcatronolrmagrng methods. bronchoscop). and mcdrastmoscop) prowdes bcttcr rlcctmn olsurgrcal candidates and hence reduces Ihe rate of unrcscctablc opcrabons
lung camxr Nakano N. Oyama S. Kolake Y, Yasumitsu T . Deparrmenl of Surgge~, h’alronal Sanolortum. Ehrme Hosprtol. 366. Yokonowara. Shmenobu-
cho, Onsen-gun. Ehtme 791-02. Jbn J MecJ Ultras& 1995,22:27-30. We evaluated the usefulness of ultrasonographic studres m the
dragnow of pleural adhesmn before surgery in I20 patients wrth lung cancer Senritwlty, specilicity, and accuracy were 63%. 81%. and 72%. respectively, in the realtime diagnoses ofpleural adhesmn m 58 parents with ultrawrwgraphic lindings indicative oflung tumor: they were 3 I% 80%. and 68%. respectively m 62 patrents whose ultrasonographrc lindrnas were not indicative of lungtumor Sensitivity was signdicantly hrgheirn parents with ultrasono~raphrc Iindmgs indic&e of lung tumor than rn those with negative lindmgs cp>o 05). Our results indicate that ultrasonographrc diagnosis of pleural adhesmn IS feasible? its specdicity was about 80%. whether lung tumor was present or not.
Lung carxer complicating pregnancy: Case report and review of literature Van Winter IT . Wilkowske MA, Shaw EG, Ogbum PL Jr, Pritchard DI. Department ofObsteb~cdGvneco/wv, Mwo Clinic/&h&e,: 200 First
S&d SW Riches&,: MN jS905. t&y0 &in Pmc 1995;70:384-7. Lung cancer during pregnancy is rare. Herein we describe a case of
metmatic cancer of the lung rn a 36year-old pregnant patient whose initial mmplamt was pain in the kfl thigh. Management of this neoplasm during pregnancy depends on the gestational age of the fetus and the potential operability of the tumor. Surgical, chemotherapeutic, and radiation management considerations are discussed.
Cutaneous XC: Metastases with a predikctio” for lungs 6years after excision of the primary tumour Panayrotou BN. Aravindan N. Smha SK, Ryact K Deportment 01
Clrnrcol Phormocologv, Ci@ General Hosprtal, Stoke-on-Trenl S-T4
6QG Br J Clin Pratt 1995.49 107-S An SO-year-old woman developed an ulcerated. moderately
ddferenliated squamws cell carcuwna (SCC) on the lower leg. Despite local excismn and radrolherapy, the parent presented 6 years later with multrple lung rnerastases whrch were histologically mdistingurshable from the orrginal skin turnour There was no evidence of metaslases to lymph nodcs or other vwxra
Preoperative work-up for primary bronchogenic cancer Carette MF. Bawl M. Lehreton C. Chooier I. Boudehene F. Wallavs C et al Servtce de Rodtologte. Hoprrol Tenon. 4, RUP de lo Ch,ne, F
75020 Pans Feud1 Radio1 1995;35:26-38. We recall the I987 lungcarcinoma TNM classrfica~~on, and imagng
powbihties of exploration of local IT), regional (N) and metastadc extension Criteria of mvolvement for each method are studred: the sensitivrty and specificrty of these criteria are diwrrsed. Computed
