Curso_BIZ0305_(2015)_files/Clase-Determinação do sexo.pdf
Transcript of Curso_BIZ0305_(2015)_files/Clase-Determinação do sexo.pdf
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Determinação do sexo
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Determinação do sexo em mamiferos
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Determinação do sexo em mamiferos
?
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Diferenciação das gónadas humanas (promordio gonadal)
(Cume genital)
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Diferenciação das gónadas humanas (testículo)
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Diferenciação das gónadas humanas (ovario)
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Desenvolvimento das góndas e ductos gonadais em mamíferos (Parte 1)
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Desenvolvimento das góndas e ductos gonadais em mamíferos (Parte 2)
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Desenvolvimento das góndas e ductos gonadais em mamíferos (Parte 3)
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Camondongo XX com transgene Sry é macho
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Genes reguladores da gónada masculina
Eggers et al., 2014
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Migração de células mesonéfricas em rudimentos gonadais Sry+ (Parte I)
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Migração de células mesonéfricas em rudimentos gonadais Sry+ (Parte II)
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Migração de células mesonéfricas em rudimentos gonadais Sry+ (Parte III)
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Capacidade de Sox9 de gerar testículos
gónada
mesonefros
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Mecanismo proposto para a determinação do sexo primaria em mamíferos
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Eggers et al., 2014
Genes reguladores da gónada femenina
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Reversão do sexo em humanos al ter duas copias do locus DAX1
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Expressão de Dax1 na cume genital do camndongo
gonada
mesonefros
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Individuos XY com síndrome de insensitividade de androgenos
“Women with AIS and related DSD conditions who want AIS to be represented by real, proud
people instead of stigmatizing pictures where the face has been removed.”
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Regiões da genitalia masculina dependente de testosterona- é dihydrotestosterona
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Determinação do sexo em mamiferos
?
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Insetos ginandromorfos
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Cascada regulatoria proposta da detrminação do sexo somático em Drosófila
Como se ativa diferencialmente o Sxl?
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17.16 Differential activation of the Sxl gene in females and males (Part 1)
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17.16 Differential activation of the Sxl gene in females and males (Part 2)
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17.16 Differential activation of the Sxl gene in females and males (Part 3)
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17.16 Differential activation of the Sxl gene in females and males (Part 4)
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17.18 Stereogram showing binding of tra pre-mRNA by the cleft of the Sxl protein
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17.17 Sex-specific RNA splicing in four major Drosophila sex-determining genes
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Tentilhao ginandromorfo com células ZZ (macho) na dereita, é células ZW (femea) na izquerda
AR in situ hybridization
Hiugh Vocal Center
Manolakou et al. 2006
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Determinação do sexo dependente à temperatura em três especies de reptiles