CURRICULUM VITAE - RICHARD W. SMALLING, … American Heart Association, Texas Affiliate: Paul V....

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CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD. Revised May 2014 PERSONAL: Date/Place of Birth - October 16, 1948; Baytown, Texas Citizenship - United States Social - Married: Sharon Lechter Smalling Children: Geoffrey, Elizabeth and Stephanie Foreign Languages - Knowledge of Italian, French, Spanish Hobbies - Swimming, golf, fly fishing, boating, skiing, scuba diving, cooking and photography Address - The University of Texas-Houston Medical School, Division of Cardiology, 6431 Fannin St., MSB 1.246, Houston, Texas 77030, Tel (713)500 6559; Fax (713)500 6560 EDUCATION: 1964 - 1966 Notre Dame International School, Rome, Italy 1966 - 1970 University of Texas, Austin B.S., Aerospace Engineering 1970 - 1972 University of Texas, Austin M.S., Mechanical Engineering (Biomedical Engineering Core Curriculum) 1972 - 1975 University of Texas-Houston Medical School Doctor of Medicine (MD) 1974 - 1977 University of Texas Graduate School of Biomedical Sciences - Houston, Doctor of Philosophy (Ph.D.) CLINICAL TRAINING: 7/78 - 6/80 Cardiology Fellow, University Hospital and Veterans Administration Hospital, University of California, San Diego Medical Center: John Ross, Jr. MD 6/75 - 6/78 Internship and Residency, Straight Medicine, University Hospital, Veterans Administration Hospital, University of California, San Diego Medical Center: Helen Ranney, MD

Transcript of CURRICULUM VITAE - RICHARD W. SMALLING, … American Heart Association, Texas Affiliate: Paul V....

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

PERSONAL: Date/Place of Birth - October 16, 1948; Baytown, Texas Citizenship - United States Social - Married: Sharon Lechter Smalling Children: Geoffrey, Elizabeth and Stephanie Foreign Languages - Knowledge of Italian, French, Spanish Hobbies - Swimming, golf, fly fishing, boating, skiing, scuba diving,

cooking and photography Address - The University of Texas-Houston Medical School, Division

of Cardiology, 6431 Fannin St., MSB 1.246, Houston, Texas 77030, Tel (713)500 6559; Fax (713)500 6560

EDUCATION: 1964 - 1966 Notre Dame International School, Rome, Italy 1966 - 1970 University of Texas, Austin B.S., Aerospace Engineering 1970 - 1972 University of Texas, Austin M.S., Mechanical Engineering (Biomedical Engineering Core Curriculum) 1972 - 1975 University of Texas-Houston Medical School Doctor of Medicine (MD) 1974 - 1977 University of Texas Graduate School of Biomedical

Sciences - Houston, Doctor of Philosophy (Ph.D.) CLINICAL TRAINING: 7/78 - 6/80 Cardiology Fellow, University Hospital and Veterans

Administration Hospital, University of California, San Diego Medical Center: John Ross, Jr. MD

6/75 - 6/78 Internship and Residency, Straight Medicine, University Hospital, Veterans Administration Hospital, University of

California, San Diego Medical Center: Helen Ranney, MD

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

CERTIFICATION: 1978 Diplomate, American Board of Internal Medicine 1981 Diplomate, American Board of Internal Med., Cardiovascular Disease 1999 Diplomate, American Board of Interventional Cardiology 2009 Diplomate, American Board of Internal Medicine 2010 Diplomate, American Board of Internal Medicine, Interventional Cardiology MEDICAL LICENSURE: 1975 - present Texas 1975 - 1980 California

HONORS/AWARDS:

2007 – Present James D. Woods Distinguished Chair in Cardiovascular

Medicine

2013-2014 Dean’s Teaching Excellence Award

2013 Southeastern Texas’ Top Doctors

2004 - 2013 Texas Super Doctor

2010-2011 Dean’s Teaching Excellence Award

2009 - 2010 Top Cardiologist by the International Association of

Cardiologists

2009 - 2010 IAC Top Cardiologist in Houston, TX

2009 - 2010 Best Doctors in America

2002 - 2009 Top Docs of Houston

2001 – 2013 America’s Top Doctors

2002 Distinguished Physician Memorial Hermann Hospital 2000 - 2001 AHA, Houston Division, Paul Dudley White Award 2000 - 2001 Excellence Awards 2000 2000 AHA-Houston Heart Ball Medical Honoree 1997 The University of Texas at Austin, College of Engineering:

Distinguished Graduate Award

1997 University of Texas Medical School, Houston: Jay Brent

Sterling Professorship in Cardiovascular Medicine

1994 American Heart Association, Texas Affiliate: Paul V.

Ledbetter, MD, Medical Physician Volunteer of the Year

Award

1993, 1994, 1997, 2004 Outstanding Teacher Award, Division of Cardiology –

UTMSH

1992 - 1994 Outstanding Teacher Award, Physical Diagnosis Course

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

1992 Henry Christian Award, AFCR, ASCI

1991 University of Texas Medical School, Houston:

Distinguished Alumnus Award

1991 American Heart Association, Houston Chapter: Award of

Excellence

1990 - 1991 University of Texas Medical School, Houston: Outstanding

Teacher in Mechanisms of Disease Course, Second Year

Students

1990 American Heart Association, Texas Affiliate: Distinguished

Service Award

1989 American Heart Association, Houston Chapter: Robert J.

Cruikshank Volunteer of the Year Award

1986 The University of Texas, Austin, Outstanding Young

Texas-Ex Award

1985 - 1986, 1988 - 1998 University of Texas Medical School, Houston: Deans'

Teaching Award

1980 - 1985 National Institute of Health Clinical Investigator Award

1975 Alpha Omega Alpha, Honorary Medical Society

1975 The University of Texas Graduate School of Biomedical

Sciences Merit Scholarship of Excellence

1971 Phi Kappa Phi, Honorary Scholastic Society

1970 Tau Beta Pi, Honorary Engineering Society

EMPLOYMENT:

9/10 – Present Adjoint Professor, University of Texas at Austin, Department of Biomedical Engineering

7/06 – Present Director of Interventional Cardiovascular Medicine,

University of Texas Medical School at Houston and the Memorial Hermann Heart and Vascular Institute.

2/92 - Present Professor of Medicine, Division of Cardiovascular

Medicine, Department of Internal Medicine, University of Texas Medical School - Houston

7/01 – 7/06 Interim Director, Division of Cardiology, Department of

Internal Medicine, University of Texas – Houston Medical School

5/94 - 2006 Director, Clinical Cardiology, Hermann Hospital, Houston

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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2/89 – 7/01 Co-Director, Division of Cardiology, Department of Internal Medicine, University of Texas Medical School - Houston

7/85 - 2/92 Associate Professor of Medicine, Division of Cardiology,

Department of Internal Medicine, University of Texas Medical School - Houston

7/80 - 6/85 Assistant Professor of Medicine, Division of Cardiology,

Department of Internal Medicine, University of Texas Medical School - Houston

Assistant Professor, University of Texas Graduate School

of Biomedical Sciences -Houston 12/72 - 2/74 Research Assistant, Department of Medicine, University of

Texas Medical School – Houston GRANTS/AWARDS:

Current:

2013 – present Synchronous Valveless Pulsatile Support Device for

the Failing Heart. Principle Investigator. NIH

funded.

2013 – present ABSORB III Randomized Control Trial. Co-

Investigator.

2013 – present AMPLATZER Cardiac Plug Clinical Investigation.

Co-Investigator. Funding amount: per patient

enrolled. Funding agency: St. Jude Medical.

2013 – present COAPT, Clinical outcomes assessment of the

Mitraclip Percutaneous Therapy for High Surgical

Risk Patients. Principle Investigator. Funding

amount: per patient enrolled. Funding agency:

Edwards Lifesciences.

2013 – present PRESERVE, Infusion of AMR-001, a bone marrow

derived autologous, vs. placebo in patients with acute

myocardial infarction. Co-Investigator.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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2012 – present REDUCE – IT Evaluate effect of AMR101 on CV

Health and Mortality in Hypertriglyceridemic

patients with CV disease or at high risk for

Cardiovascular Desase. Principle Investigator.

Funding Agency: Amarin Pharma Inc. Funding

amount: per patient enrolled.

2012 – present Simplicity HTN-3 Trial. Co-Investigator. Funding

amount: per patient. Funding agency: Medtronic.

2011 – present Placement of AoRtic TraNscathetER Valve

(PARTNER 2 Trial). Principal Investigator.

Funding Agency: Edwards. Funding amount: per

patient enrolled.

2011 – present Cardioprotective Effects of an Endothelin Type A

Receptor Antagonist, Ambrisantan. Principle

Investigator. Funding Agency: Gilead, Inc.

2010 – present SOLID TIMI 52, Clinical outcomes of Darapladib vs.

placebo in subjects following acute coronary

syndrome. Co-investigator. Funding agency:

2009 – present AngeLmed for Early Recognition and Treatment of

STEMI Study (ALERTS). Principal Investigator.

Funding agency: Angel Medical Systems. Funding

amount: per patient enrolled.

2009 – present A Multi-center, Randomized, Controlled Study of

Mechanical Left Ventricular Unloading with

Counterpulsation to Reduce Infarct Sue Ere-PC1 for

Acute Myocardial Infarction (CRISP AMI).

Principal Investigator. Funding agency: Maquet.

Funding amount: per patient enrolled. IND Number:

11055.

2007 – present Intravascular Photoacoustic Trial. Principle

Investigator. Funding agency: NIH subaward.

Funding amount: 300,000.00

2006 – present Stenting and Angioplasty with Protection in Patients

at HIgh-Risk for Endarterectomy Protocol Number

P06-3603 (SAPPHIRE WW). Principal Investigator.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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Funding Agency: Cordis. Funding amount: per

patient enrolled.

2005 – present Everest I and II study of the Evalve Cardiovascular

Valve Repair System (CVRS) Endovascular edge to

edge repair study. Principal Investigator. Funding

Agency: Edwards. Funding amount: per patient

enrolled.

2005 – present PATCAR Pre-Hospital Administration Of

Thrombolytic Therapy With Urgent Culprit Artery

Revascularization: Pilot Trial National Trial

Organizer and Principal Investigator (Pilot funding

$394K- Centocor/Scios). HSC-MS-03-021. FDA

2002 – present The Randomized Evaluation of Stroke Comparing

PFO Closure to Established Current Standard of Care

Treatment (RESPECT Trial). Principal Investigator.

Funding agency: AGA. Funding amount: per patient

enrolled.

2001 - 2010 NIH & NINDS CREST Trial (Carotid Revascularization

Endarterectomy vs Stent Trial) Local Co-PI. HSC-MS-01-

052. Sponsor: NIH and UNDNJ: Grant #R01 NS38384.

IRB Approval: April 30, 2001. 14 lead-ins and 1

randomized.

2002 – 2009 TAXUS Study (Treatment of De Novo Coronary Disease

Using a Single Paclitaxel-Eluting Stent) UTMS/Memorial

Hermann Heart Center. HSC-MS-01-248. Principal

Investigator. Sponsor: Boston Scientific: 10 patients.

IRB Approval: January 31, 2002. 2002 – 2009 BEACH (Boston Scientific EPI: A Carotid Stenting Trial

for High-Risk Surgical Patients) Trial UTMS/Memorial Hermann Heart Center; Principal Investigator. HSC-MS-02-127. Sponsor: Boston Scientific: 9 patients. IRB Approval: August 9, 2002.

2002 – 2009 Amplatzer PFO HDE Occluder Compassionate Use Study

and Registry, HSC-MS-00-180A. Principal Investigator. IRB Approval: December 6, 2002 (Compassionate Use), December 20, 2002.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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2004 – 2008 Infarct Salvage Using IABP Initiated Just Prior to

Reperfusion in a Porcine Infarction Reperfusion Model:

Principal Investigator. Funding agency: Datascope, Inc.;

$124,600.

2003 – 2008 TAXUS V: A Randomized, Double-Blind Trial to Assess

TAXUS Paclitaxel-Eluting Coronary Stents, Slow-Release

Formulation, in the Treatment of High Risk De Novo

Coronary Lesions: Principal Investigator. Sponsor:

Boston Scientific; 2 patients. IRB approval: March 18,

2003.

2002 – 2008 Symbiot III Trial (A Prospective Randomized Trial

Evaluating the Symbiot III Covered Stent System in

Saphenous Vein Grafts) UTMS/Memorial Hermann

Heart Center; Principal Investigator. HSC-MS-02-

037. Sponsor: Boston Scientific: 8 patients. IRB

Approval: April 9, 2002.

2004 - 2007 Use of High Frequency IVUS for the Detection of

Vulnerable Atherosclerotic Plaque: Co-Principal

Investigator. Funding agency: Boston Scientific.

Funding: $254,000.

2003 – 2007 Evaluation of Infarct Salvage Using the A-Med

LVAD System in a Porcine Infarction Reperfusion

Model: Principal Investigator. A-Med Inc. and the

John Henry Ewell and Walker New Coronary

Physiology Research Endowment. Funding: A-Med

Inc.; $75,000.

2002 – 2007 GREAT (Guided Radio Frequency Energy Ablation of Total Occlusions) Study UTMS/Memorial Hermann Heart Center; Principal Investigator.

2002 – 2007 TAXUS IV-SR: Treatment of De Novo Coronary

Disease Using a Single Paclitaxel-Eluting Stent.

HSC-MS-01-248. Principal Investigator. Sponsor:

Boston Scientific: 10 patients. IRB Approval:

January 31, 2002. 2002 – 2007 A Single Center Registry of Carotid Stenting With Distal

Protection for the Treatment of Obstructive Carotid Artery

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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Disease, HSC-MS-01-239. Principal Investigator. IRB Approval: March 11, 2002. Non-funded, 9 patients.

2003 – 2006 Randomized Evaluation of Recurrent Stroke

Comparing PFO Closure to Established Current

Standard of Care Treatment: Principal Investigator.

Sponsor: AGA Medical; 1 patient in registry. IRB

approval – February 20, 2003.

2002 – 2004 Polarization and Differential Phase Optical

Coherence Tomography with IVUS for the Detection

of Vulnerable Atherosclerotic Plaques. Collaborative

effort of University of Texas Medical School,

Cardiology Division and University of Texas at

Austin Biomedical Engineering Laser Laboratory.

Principal Investigator. Funding: Whitaker Seed

grant; $20,000. 2000 – 2004 Percutaneous Closure of Intracardiac Defects Utilizing the

CardioSeal Device: A Longitudinal Outcomes Study. CardioSeal Protocol, HSC-MS-00-023. Principal Investigator. IRB Approval: February 29, 2000. Non-funded; 66 patients.

2001 – 2003 CardioShield Application Protects During Transluminal

Intervention of Vein Grafts by Reducing Emboli (Captive) Pivotal Study. HSC-MS-01-124. Principal Investigator. Sponsor: Med Nova, 4 patients. IRB Approval: August 13, 2001.

1997 – 2002 Principal Investigator, Carotid Artery

Angioplasty/Stenting: A Compassionate Use Study. 1999 – 2001 A Phase III, Randomized, Open-Label Trial Evaluating the

Efficacy and Safety of ReoPro (Abciximab) in Combination with Reduced Dose Retavase/Rapilysin (Recombinant Plasminogen Activator, Reteplase, r-PA) for the Treatment of Acute Myocardial Infarction (GUSTO IV AMI). Principal Investigator.

1999 – 2001 Prevention of REStenosis by Tranilast and its Outcomes

(PRESTO): A Placebo-Controlled Trial of Two Doses and Two Durations of Tranilast (Protocol 004). Principal Investigator.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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1999 – 2001 The Acute Coronary Syndromes Registry. Steering Committee and Principal Investigator.

1999 – 2001 GUSTO IV Pilot – “SPEED” Principal Investigator and

Member Steering Committee. 1998 – 2001 TIMI 19 – Pre-Hospital Thrombolysis Trial – Steering

Committee. 1997 – 2001 Percutaneous Implantation of Uncovered Wire Mesh Stents

With Coil Embolization in Patients With Abdominal Aortic Aneurysms: A Compassionate Use Study. Principal Investigator.

1997 – 2001 TACTICS TIMI-19 Clinical Trial, Co-Investigator. 1997 – 2001 US Army – DREAMS Trial, Co-Investigator Project I-E,

Selective Adenosine Infusion Distal to Coronary Occlusions Prior to Direct PTCA for Acute MI for Infarct Salvage. Project 2-B: Mechanisms of Infarct Salvage with Selective Adenosine Infusion in Regional Myocardial Ischemia.

1995 - 1999 GUSTO III Trial, Accelerated t-Pa vs. r-Pa in acute

myocardial infarction. Steering committee and Principal investigator.

1995 - 1997 IN TIME Trial - A Dose Ranging Trial of n-PA vs.

Accelerated t-PA in Acute Myocardial Infarction. Steering committee and Principal investigator.

1995 - 1997 STARS Trial, Randomized trial of anticoagulation

regimens in native coronary arteries. Principal Investigator.

1995 - 1997 RAVES Trial, Reduced anticoagulation in vein graft stent

trial, Johnson and Johnson Interventional Systems. Principal Investigator.

1995 - 1997 Texas Biotechnology Corporation, "Evaluation of TBC

Compounds in the Prevention of Reperfusion Injury in a Canine Myocardial Infarction Model." Principal Investigator.

1995 - 1997 LIFT - A randomized trial of Liposomal-Pg-E1 (C-53) in

Acute Myocardial Infarction. Steering Committee/ National Principal Investigator.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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1993 - 1996 Steering Committee, Johnson & Johnson Interventional Systems, "European Trials of the 14-F HemoPump in assisted PTCA and acute myocardial infarction."

1992 - 1996 Liposome Company Inc., "Effect of TLC-C53 on

expression of integrins and selectins in canine myocardial reperfusion injury."

1993 - 1995 Johnson & Johnson Interventional Systems, "SAVED Trial

(Randomized trial of PTCA vs. Stenting in saphenous vein grafts)."

1993 - 1994 RAPID II Trial: "Double bolus r-PA vs. accelerated t-PA

in acute myocardial infarction", International Steering Committee/Principal Investigator, Boehringer Mannheim.

1992 - 1994 Baxter LIS Division, "Effect of angioscopically detected

plaque rupture or lesional thrombus on acute and late outcome of PTCA."

1992 - 1993 USCI-BARD Incorporated, "Transluminal Rotational

Atherectomy", animal investigation and clinical trials. 1/92 - 1/93 Liposome Company Inc., "Enhanced Velocity of

Thrombolysis Using Liposomal Bound PGE1 and Streptokinase Compared to Streptokinase Alone in a Canine Model."

"The Effect of Liposome Bound PGE1 Administered

Immediately Prior to Reperfusion on Reperfusion Injury, Infarct Size, Regional WBC Activation, Infarct Expansion and LV Function."

11/91 - 11/92 California Biotechnology Inc., "A Phase II Dose Response,

Safety & Efficacy Study of Anaritide Acetate (ANP) for Prophylaxis of Radio Contrast-Induced Nephropathy in Patients at High Risk Undergoing Radiographic Procedures with Contrast."

9/91 - 8/92 "A Randomized Dose Responsive Study to Evaluate the

Effects of BM 06.022 (r-PA), relative to Alteplase on Coronary Artery Patency and Safety in Patients with Acute Myocardial Infarction", International Trial (38 centers, 4 countries). Steering Committee/Principal Investigator Boehringer Mannheim Pharmaceuticals,

7/90 - 12/91 The Liposome Company, Inc., "Effect of Liposome Bound

Prostaglandin E1 on Reperfusion Injury."

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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10/87 - 7/91 Nimbus, Inc. and Johnson & Johnson, "Effect of the

Hemopump on Left Ventricular Salvage during Acute Ischemia Animal Studies and Clinical Trials."

2/88 - 6/90 Abbott Laboratories, "A Randomized Trial of Urokinase

vs. TPA in Acute Myocardial Infarction." 4/85 - 7/87 Genentech, Inc., South San Francisco, California,

"Randomized Multicenter Trials of IV TPA in Myocardial Infarction."

7/85 - 6/87 USCI - Bard, Inc., Billerica, Massachusetts, "Effect of

Synchronized Coronary Sinus Retroperfusion on Regional Function during Regional Ischemia."

7/80 - 6/85 National Institute of Health, Clinical Investigator Award. 7/81 - 6/82 American Heart Association, Texas Affiliate Grant-In-Aid. 1973-74, 1983-84 Schwarz Foundation, Houston, Texas. PATENTS: US 8,715,305 Magnetic Ventricular Connector Issued May 6, 2014 US 8,568,113 Positive Displacement Pump System and Method Issued October 29, 2013 US 8,386,040 System and Method for Pump Variable Stroke. Issued February 26, 2013. US 8,366,401 Positive Displacement Pump System and Method with Rotating Valve. Issued February 5, 2013. US 8,167,593 System and Method for Pump with Deformable Bearing Surface. Issued May 1, 2012 USSN 6,750,119 Percutaneous Implantation of Partially Covered Stents in Aneurysmally Dilated Arterial Segments With Subsequent Embolization and Obliteration of the Aneurysm Cavity. Issued May 4, 2004 AREAS OF RESEARCH: Effect of global mechanical loading on endothelial endothelin release, apoptosis and size in a myocardial infarction-reperfusion model.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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Optimization of treatment of acute coronary and cerebral ischemia in a collaborative metropolitan setting. Computer Image Enhancement and Analysis of Angiographic and Scintigraphic Images New Device Development for Coronary Revascularization New Device Development for Circulatory Support GRADUATE STUDENTS SUPERVISED: Shriram Sethuraman Differential Phase Optical Coherence Tomography To

Detect Vulnerable Atherosclerotic Plaques MSE May, 2003 Shriram Sethuraman Combined Intravascular Ultrasound and Photo Acoustic

Imaging PhD August, 2007 Jimmy Su Received his PhD in Biomedical Engineering on July 15,

2011. He is currently a Post-Doctoral Scholar at UC-Irvine. Bo Wang Received her PhD in Biomedical Engineering on May 25,

2011. Doug Yeager He is currently a Graduate Research Assistant pursuing his

PhD in Biomedical Engineering. He is expected to graduate Spring/Summer 2013.

EDITORIAL BOARDS: Catheterization and Cardiovascular Diagnosis Journal of American College of Cardiology-Intervention Journal of Interventional Cardiology Frequent Reviewer: American Heart Journal American Journal of Cardiology

American Journal of Physiology: Heart and Circulatory Physiology

Catheterization and Cardiovascular Interventions Archives of Internal Medicine CHEST Circulation Journal of American Medical Association Journal of Arteriosclerosis and Thrombosis New England Journal of Medicine CONSULTANT:

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

2000 – 2008 Medical Advisory Board, Boston Scientific 1992 - present Texas State Board of Medical Examiners 2004 Texas Dept. of State Health Services –Cardiovascular,

Diagnostic & Therapeutic Issues 1997 – 2004 Centocor Incorporated 1999 – 2002 Endovasc Incorporated 1989 - 2000 SCIMED/Boston Scientific Incorporated 1995 - 1998 Medtronic Incorporated, Percutaneous LV Assist 1994 - 1998 Boehringer Mannheim Incorporated; International

Advisory Board for RetePlase and Troponin-t 1987 - 1992 USCI Bard Incorporated LOCAL AND NATIONAL COMMITTEES/STUDY SECTIONS: 2006 – Present Governor’s EMS and Trauma Advisory Council (GETAC),

Cardiac Care Committee 2007 - 2013 ACC Interventional Section Leadership Council 2008 - 2010 NIH Center for Scientific Review Special Emphasis Panel 1997-2010 HCMS (Harris County Medical Society) Emergency

Medical Services Committee 2004 Atherosclerotic Vascular Disease Conference, Writing

Group VI: Revascularization, American Heart Association 1998 - 2003 Exhibits Subcommittee, American College of Cardiology 1997 WELLCHOICE Credentialing Committee 1992, 1994 Basic Research Foundation, administered by The Israel

Academy of Sciences and Humanities 1991 - 1995 Central Research Review Committee, American Heart

Association, Texas Affiliate 1988 - 1989 International Society of Coronary Sinus Interventions,

Scientific Advisory Committee Chairman 1985 - 1988 Study Section B-II, Cardiovascular, American Heart

Association (National) 9/85 NIH Advisory Panel Member, Role of Lasers and Fiber optics in Cardiovascular

Medicine

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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ACADEMIC COMMITTEES: 2012 - present Chair, UTHealth Division of Cardiology and Hyperbaric

Medicine’s Scientific Pre-Review Committee 2005 - present University of Texas Health Science Center at Houston:

InterFaculty Council 1999 – 2001 Continuing Medical Education Committee 1993 - 1997 Subcommittee to establish Problem Based Learning in the

Cardiovascular Block, case writer for cardiovascular cases 1995 Department of Medicine Internal Review - Chair: Clinical

Activities Subcommittee 1993 - 1994 Department of Ophthalmology Internal Review Committee 1992 - 1994 PDRC Advisory Board 1988 - 1989 Department of Internal Medicine, Quality Assurance

Committee, Member 1988 - 1989 Member, Subcommittee for Evaluation of the Second Year

Curriculum 1986 - 1987 Faculty Senate, University of Texas Medical School -

Houston 1986 - 1989 Educational Policy Committee, University of Texas

Medical School - Houston 1984 - 1986 Curriculum Committee, Task Force Chairman: Review of

Cardiovascular System Instruction 1983 - 1984 M.D./Ph.D. Committee, University of Texas Medical

School - Houston 1982 - 1983 Advisory Committee on the Implications of Computer,

Chairman, Patient Care Subcommittee PROFESSIONAL ACTIVITIES: 1997 - present Northeast Medical Center Hospital, Provisional Staff 1997 –present Park Plaza Hospital, Courtesy Staff 1980 - present Attending Cardiologist 1993 - 2006 Director, Center for Cardiovascular Medicine 1990 - 2006 Medical Director and Founder, Hermann Heart Center

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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1988 - 2006 Director, Clinical Cardiology, Hermann Hospital 1981 - 2004 Director, Cardiac Catheterization Laboratory 1995 - 1999 Hermann Hospital, Houston, Texas President, Medical Staff, Hermann Hospital 1996 Member, Quality Steering Committee and Medical Staff

Quality Review 1995 - 1996 Board Member, Hermann Volunteers Organization 1993 - 1996 Member, Quality Assurance Steering Committee 1992 - 1994 President-Elect, Medical Staff 1990 - 1992 Chairman, Medical Staff Quality Review Committee 1988 - 1990 Member, Physicians Quality Assurance Committee 1988 - 1990 Chairman, Patient Care Committee 1985 - 1989 Member, Radiation Safety Committee 1983 - 1987 Chairman, CPR Committee American Heart Association (National) 1998 - present Chairman, Medical and Scientific Committee 1991 - present Member, Medical and Scientific Committee 1994 - 2003 Associate Editor of Circulation 1989 - 2001 Member, Board of Directors 1999 - 2000 President, Texas Affiliate 1995 - 2000 Council Representative, Council of Clinical Cardiology

1998 - 1999 President Elect, Texas Affiliate 1997 - 1998 First Vice President, Texas Affiliate 1996 - 1998 Chairman of the Council Representatives of the Council on Clinical Cardiology 1996 - 1998 Executive Committee of the Council on Clinical Cardiology 1992 - 1994 Vice President, Chairman of Council V 1991 - 1994 Chairman, Health Star Task Force 1992 - 1993 Chairman, School Site Subcommittee 1992 - 1993 Chairman, Task Force for Access of Cardiovascular Drugs

to the Medically Indigent 1990 - 1993 Member, Program Committee 1990 - 1991 Member, School Site Subcommittee 1990 - 1991 Member, Work Site Subcommittee 1990 - 1991 Member, Nominating Committee (Houston Chapter) 1989 - present Chairman, Task Force for Development and

Implementation of "Health Star" Low Cholesterol, Low Fat, High Fiber School Lunch Program

1988 - 1989 President, Houston Chapter 1987 - 1988 President-Elect 1987 - 1988 Program Committee Chairman

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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1985 - 1988 Study Section B2 Cardiovascular, AHA 1986 - 1987 First Vice President (Texas Affiliate, Inc.) 1984 - 1995 Board Member, Harris County Chapter 1984 - 1986 Chairman, Task Force on Fitness in Business and Industry Alumni Association, University of Texas Medical School, Houston 1987 - 1995 Member, Editorial Advisory Board 1983 - 1984 President 1981 - 1983 Board Member American College of Cardiology 2013 – present Surgeon Scientific Council 2007 – 2012 Interventional Cardiology Council 1998 - 2005 Exhibits Subcommittee MEMBERSHIP IN PROFESSIONAL SOCIETIES: American College of Cardiology 1982 - present Fellow American Heart Association (National) Member, Council on Basic Sciences Fellow, Council on CIRCULATION Fellow, Council on Clinical Cardiology 1990 - 1994 Association of Professors of Cardiology American Medical Association Member Texas Medical Association Member Harris County Medical Society Member 2007-2009 Emergency Medical Services Committee Houston Cardiology Society 1986 - 1987 President 1985 - 1986 President Elect 1984 - 1985 Secretary Treasurer 1980 - present Member

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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The Society for Cardiac Angiography and Interventions 1989 - present Fellow American Society of Internal Medicine 1990 - present Fellow Texas Society of Internal Medicine 1990 - present Member Association of University Cardiologists 1999 - 2012 Member

2013 – present Emeritus Member

Texas Club of Cardiologist

2000 Member

2002 Vice President

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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PUBLICATIONS (Abstracts): * 1) Smalling RW, Cole JS, Skolnick MH, Glaeser DH, Holland PA. Comparison of

computer and semi-automated image processing techniques in the analysis of cine ventriculograms. Proceedings: Association for the Advancement of Medical Instrumentation: Boston, Massachusetts, 1975.

* 2) Smalling RW, Cole JS, Skolnick MH. Digital boundary detection, volumetric and

wall motion analysis of left ventricular cine angiograms. Am J Cardiol 1979; 43:376.

3) Reduto LA, Smalling RW, Freund GC, Gould KL. Lysis of coronary artery

thrombosis with intracoronary streptokinase in acute myocardial infarction. Am J Cardiol 1981; 45:493.

* 4) Smalling RW, Kelley KO, Kirkeeide RL, Richards PM, Gould KL. Enhanced

sensitivity of early diastolic functional indices over early systolic functional indices in detecting ischemia. Clin Res 1982; 29:816A.

* 5) Smalling RW, Kelley KO, Kirkeeide RL, Richards PM, Gould KL. Comparison of

early diastolic and early systolic functional indices in detecting ischemia. Clin Res 1982; 30:222A.

6) Smalling RW, Kelley KO, Kirkeeide RL, Richards PM, Gould KL. Dependency of

regional left ventricular function on instantaneous wall stress in ischemia and hyperemia. Clin Res 1982; 30:222A.

* 7) Smalling RW, Freund GC, Fuentes F, Reduto LA, Gould KL. Intracoronary

thrombolysis up to 18 hours after onset of acute myocardial infarction causes sustained improvement in left ventricular function. Clin Res 1982; 30:222A.

8) Kirkeeide RL, Smalling RW, Gould KL. Automated measurement of artery

diameter from arteriograms. Circulation 1982; 66:II-325. * 9) Smalling RW, Kelley KO, Kirkeeide RL, Fisher DJ, Richards PM, Gould KL.

Regional left ventricular function is independent of coronary pressure at constant coronary flow. Circulation 1982; 66:II-44.

10) Smalling RW, Walker WE, Fuentes F, Sterling RP, Hicks CH, Freund GC, Matthews

MW, Gould KL. Transmural myocardial infarction in the absence of total coronary occlusion: clinical implications. Clin Res 1982; 30:834A.

* 11) Smalling RW, Fuentes F, Hicks CH, Freund GC, Matthews MW, Reduto LA, Gould

KL. Sustained improvement in left ventricular function with intracoronary thrombolysis greater than six hours after onset of pain in evolving myocardial infarction. J Am Coll Cardiol 1983; 1(2):579.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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* 12) Smalling RW, Fuentes F, Hicks CH, Matthews MW, Freund GC, Reduto LA, Gould KL. Reduced mortality with intracoronary streptokinase administration during evolving myocardial infarction. J Am Coll Cardiol 1983; 1(2):591.

* 13) Smalling RW, Fuentes F, Hicks CH, Matthews MW, Freund GC, Gould KL. Failure

of presence of Q waves on admission ECG or duration from onset of chest pain to reperfusion to predict effect of intracoronary thrombolysis on left ventricular function. Clin Res 1983; 31:318A.

14) Smalling RW, Walker WE, Fuentes F, Sterling R, Hicks CH, Freund GC, Matthews

MW, Gould KL. Optimal therapy for transmural myocardial infarction secondary to subtotal coronary occlusion. Clin Res 1983; 31:218A.

15) Sterling RP, Smalling RW, Fuentes F, Walker WE, Gould KL. Early medical and

surgical reperfusion in acute myocardial infarction. Proceedings: International Cardiovascular Congress IV Scientific Program and Abstracts 1983; 30:52.

* 16) Smalling RW, Fuentes F, Hicks CH, Freund GC, Matthews MW, Kuhn J, Gould KL.

Predictors of outcome of intracoronary streptokinase therapy as assessed by change in left ventricular function. Proceedings: International Symposium on Interventional Modifications in Coronary Artery Disease, Texas Heart Institute, 1983.

* 17) Smalling RW, Fuentes F, Hicks CH, Matthews MW, Freund GC, Kuhn J, Gould KL.

Long term effects of intracoronary streptokinase therapy on total mortality: risk/benefit stratification. Proceedings: International Symposium on Interventional Modifications in Coronary Artery Disease, Texas Heart Institute, 1983.

* 18) Smalling RW, Ekas RD, Kirkeeide RL, Richards PM. Role of intraventricular

loading on regional myocardial function. Circulation 1983; 68 (II):III-305. 19) Mullani NA, Gaeta JM, Goldstein RA, Smalling RW, Ekas RD, Gould KL.

Detection of mild coronary artery stenosis with rubidium-82 and PET. Circulation 1983; 68 (III):III-386.

20) Matthews WM, Kuhn JL, Smalling RW, Fuentes F, Hicks CH, Freund GC, Gould

KL. Incidence of bleeding complications associated with intracoronary streptokinase therapy for acute myocardial infarction. Circulation 1983; 68 (III):III-292.

* 21) Smalling RW, Ekas RD, Kirkeeide RL, Richards PM, Fisher DJ. Evidence for short

term improvement in coronary collateral blood flow by oral dipyridamole. J Am Coll Cardiol 1983; 3:502.

* 22) Smalling RW, Ekas RD, Kelley KO, Richards PM, Taegtmeyer H. Correction of

regional function abnormalities in 02 deprived dog hearts by alkalosis. J Am Coll Cardiol 1983; 3:571.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

* 23) Smalling RW, Fuentes F, Hicks CH, Matthews MW, Freund G, Gould KL. Effect of infarct location and reperfusion success on overall mortality with intracoronary streptokinase therapy. J Am Coll Cardiol 1983; 3:526.

24) Goldstein RA, Hicks CH, Kuhn JL, Hartz R, Fuentes F, Smalling RW, Mullani N,

Gould KL. Myocardial infarct imaging with rubidium-82 and PET in man. Circulation 1984; 70 (II):II-9.

25) Mullani NA, Gould KL, Goldstein RA, Gaeta J, Smalling RW, Ekas RD, Hartz RK.

Gated blood pool and myocardial perfusion imaging by PET after a single IV injection of rubidium-82. Circulation 1984; 70(II):II-249.

* 26) Smalling RW, Fuentes F, Matthews MW, Kuhn JL, Hicks CH, Gould KL. Does dose

of thrombolytic agent affect outcome of thrombolytic therapy? Circulation 1984; 70(II):II-331.

* 27) Smalling RW, Ekas R, Richards P, Binnion L. Regional left ventricular function

depends on inotropic state in adjacent myocardial segments. Circulation 1984; 70(II):II-356.

28) Matthews MW, Kuhn JL, Smalling RW, Fuentes F, Gould KL. Reperfusion

symptoms with intracoronary streptokinase therapy. Circulation 1984; 70(II):II-385. * 29) Smalling RW, Kirkeeide RL, Parsel L, Nishikawa A, Ekas RD. Automated

quantitative analysis of stenoses during PTCA. J Am Coll Cardiol 1986; 7(2):64A. * 30) Smalling RW, Nishikawa A, Merhige ME, Fuentes F, Adyanthaya AV, Holmes RL,

Haynie MP, Tiberi MA, Smith SA, Kirkeeide RL, Goldstein RA, Gould KL. Dipyridamole stress positron tomographic and quantitative angiographic assessment of stenosis severity after intravenous tissue plasminogen activator and percutaneous coronary angioplasty in evolving myocardial infarction. Proceedings: International Symposium on Interventional Cardiology, Texas Heart Institute, September 21-23, 1986.

* 31) Smalling RW, Ekas RD, Ochs RL, Felli PR, Tiberi MA. Improvement in regional

myocardial blood flow and function with synchronized coronary sinus retro perfusion during brief regional ischemia: Potential for myocardial support during complex angioplasty. Proceedings: International Symposium on Interventional Cardiology, Texas Heart Institute, September 21-23, 1986.

32) Goldstein RA, Kirkeeide R, Demer L, Merhige M, Nishikawa A, Fuentes F,

Smalling RW, Mullani NA, Gould KL. Assessment of coronary flow reserve with positron tomography: A comparison with quantitative coronary arteriography. J Nucl Med 1986; 25A:6.

33) Goldstein RA, Kirkeeide R, Nishikawa A, Smalling RW, Demer L, Merhige M,

Mullani NA, Gould KL. Improvement in coronary flow reserve after coronary angioplasty as assessed with positron tomography. J Nucl Med 1986; 25A:14.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

* 34) Smalling RW, Nishikawa A, Merhige ME, Fuentes F, Adyanthaya AV, Holmes RL,

Haynie MP, Tiberi MA, Smith SA, Kirkeeide RL, Gould KL. Intravenous tissue plasminogen activator followed by percutaneous transluminal coronary angioplasty in acute myocardial infarction: Acute and follow-up quantitative angiographic analysis. Circulation 1986; 74:II-23.

35) Battey LL, Topol EJ, O'Neill WW, Smalling RW, Schumacher RR, Taylor CR,

Nishikawa A, Collen DJ, Grossbard EB, Morris DC. Single chain intravenous recombinant tissue-type plasminogen activator in acute myocardial infarction: A randomized, multicenter placebo-controlled trial. Circulation 1986; 74:II-366.

* 36) Smalling RW, Nishikawa A, Merhige ME, et al. Comparison of positron tomography

and quantitative angiography in stenosis analysis after acute thrombolysis and angioplasty in evolving myocardial infarction. J Am Coll Cardiol 1987; 9(2):179A.

37) Schumacher RR, Smalling RW, Morris DC, Grossbard EB. A multicenter

randomized comparison of two doses of recombinant tissue plasminogen activator in treatment of myocardial infarction. Circulation, Suppl. II 1988; 76(4):II-275.

38) Merhige ME, Smalling RW, Garza D, Sease D, MacLean J, Wampler R. Effect of

the hemopump left ventricular assist device on myocardial perfusion: Reduction of ischemia during coronary occlusion. Circulation, Suppl. II 1988; 76(4):II-580.

* 39) Smalling RW, Cassidy DB, Merhige M, Felli PR, Wise GM, Barrett RL, Wampler

RD. Improved hemodynamic and left ventricular unloading during acute ischemia using the hemopump left ventricular assist device compared to intra aortic balloon counter pulsation. J Am Coll Cardiol 1989; 13(2):160A.

* 40) Smalling RW, Cassidy DB, Schmidt WA, Wise GM, Felli PR, Barrett RL, Boseck

GL. Initial experience with a flexible rotational atherectomy system designed for removal of coronary and small peripheral artery atheromas. J Am Coll Cardiol 1989; 13(2):223A.

* 41) Smalling RW, Sweeney MJ, Cassidy DB, Barrett RL, Morris RE, Lammermeier DE,

Key PG, Haynie MP, Frazier OH, Wampler R. Hemodynamics in cardiogenic shock after acute myocardial infarction with the hemopump assist device. Circulation, Suppl. II 80; 4,II-624 (2477).

42) Gould KL, Kirkeeide RL, Ornish D, Stein E, Buchi M, Smalling RW. Improvement

of stenosis geometry by quantitative coronary arteriography and perfusion by positron emission tomography after adequate cholesterol lowering in man. Circulation, Suppl. II 80; 4, II-102 (0410).

43) Lachterman B, Felli P, Amirian J, Pina V, Smalling RW. Improved myocardial

blood flow during partial regional ischemia using the hemopump. Clin Res 1990; 38(2):375A.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

44) Lachterman BS, Felli P, Amirian J, Pina V, Smalling RW. Improved infarct salvage by left ventricular unloading with the hemopump immediately prior to and during reperfusion after a 2 hour coronary occlusion. J Am Coll Cardiol 1991; 17(2):134A.

45) Li G, Amirian J, Felli P, Echols B, Smalling RW. Attenuation of the no-reflow

phenomenon and improved infarct salvage by liposome bound prostaglandin-E1 prior to reperfusion. Proceedings: AAP/ASCI/AFCR National Meeting, Baltimore, Maryland, 1992. Abstract No. N-CV-0220, Clin Res 1992; 40(2):155A.

46) Anderson HV, Rosales O, Kirkeeide RL, Smalling RW, Weisman H, Willerson.

Elimination of cyclic flow variations following coronary angioplasty in humans with 7E3 monoclonal antiplatelet antibody. Proceedings: 65th Scientific Sessions - American Heart Association, New Orleans, Louisiana, November 16-19, 1992.

47) Smalling RW, Lachterman BS, Krishnaswami A, Anderson HV, Rosales O, Heibig

J, Schroth G, Nishikawa A, Ali A, Molke K. Identification of intralesional thrombus pre-intervention by coronary angioscopy comparison with coronary arteriography. Proceedings: ASCAI - Oral Abstract Session II - 16th Annual Meeting, San Antonio, Texas, May 20, 1993. Cathet Cardiovasc Diagn 1993; 29(1):80.

48) Bode C, Smalling RW, Sen S, Kalbfleisch J, Boehm E, Odenheimer DJ, Meyer-

Sabellek W, and the RAPID Investigators. Recombinant plasminogen activator angiographic phase II international dose finding study (RAPID): Patency analysis and mortality endpoints. Proceedings: 66th Scientific Sessions - American Heart Association, Atlanta, Georgia, November 8-11, 1993. Abstract No. 1563, Circulation, Suppl. 88, 1993;4(2):I-292.

49) Feld S, Li G, Amirian J, Felli P, Smalling RW. Accelerated thrombolysis, improved

epicardial and microvascular blood flow and reduced infarct size with liposome bound prostaglandin E1 in a canine thrombolysis model. Proceedings: 66th Scientific Sessions - American Heart Association, Atlanta, Georgia, November 8-11, 1993. Abstract No. 2376, Circulation, Suppl. 88, 1993; 4(2):I-442.

50) White CJ, Ramee SR, Collins TJ, Jain SP, Escobar A, Soni D, Bass TA, Heuser RR,

Teirstein PS, Bonan R, Nesto RW, Walter PD, Smalling RW, Knopf WD. Angioscopically detected coronary thrombus correlates with adverse PTCA outcome. Proceedings: 66th Scientific Sessions - American Heart Association, Atlanta, Georgia, November 8-11, 1993. Abstract No. 3206, Circulation Suppl. 88, 1993; 4(2):I-597.

* 51) Smalling RW, Bode C, Kalbfleisch J, Sen S, Feldman R, Mann D, Limbourg P,

Odenheimer DJ, Meyer-Sabellek W and the RAPID Investigators. Effects of Reteplase (r-PA) and Alteplase (rt-PA) on speed and completeness of coronary artery patency. Proceedings: Joint XII the World Congress of Cardiology and XVIth Congress of the European Society of Cardiology, Berlin, Germany, September 10-14, 1994.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

52) Smolarz A, Bode C, Smalling RW, Meyer-Sabellek W, The RAPID Investigators. Effects of Reteplase (r-PA) and Alteplase (rt-PA) on coronary artery patency and safety. Proceedings: Polish Cardiac Society, Poznan, Poland, September 15-17, 1994. Kardiologia Polska - Polish Heart Journal 1994; XLI(1):196.

* 53) Smalling RW, Bode C, Kalbfleisch J, Sen S, Limbourg P, Forycki F, Habib G,

Feldman R, Hohnloser S, A Seals for the RAPID Investigators, Hermann Hospital, Houston, TX and University of Heidelberg, Heidelberg Germany. Improvement of global and regional and LV function by the Bolus Administration of Recombinant Plasminogen Activator (r-PA) in acute myocardial infarction: A comparison with standard dose Alteplase. Proceedings: 67th Scientific Sessions - American Heart Association, Dallas, Texas, November 14-17, 1994.

* 54) Smalling RW, Uthman M, Ramanna N, Yeh E, Amirian J, Felli P, Feld S, Accad M,

Concoff A, Smith CW, Entman M, Janoff A. Suppression of ICAM-1 and P-Selectin adhesion molecule expression by Bolus IV Liposomal PGE1 (TLC-C53) immediately prior to reperfusion in a two hour canine infarct/reperfusion model. Proceedings: 44th Annual Scientific Sessions - American College of Cardiology, New Orleans, Louisiana, March 19-22, 1995. J Am Coll Cardiol 1995; 249A:972-102.

55) Savage M, Douglas J, Fischman D, Fenton S, King S, Pepine C, Bailey S, Overlie P,

Werner J, Leon M, Heuser R, Brinker J, Buchbinder M, Smalling R, Snead D, Rake R, Gebhardt S, Kerensky R, Wargovich T, Goldberg S, SAVED Trial Investigators. Coronary stents versus balloon angioplasty for aorto-coronary saphenous vein bypass graft disease: Interim results of a randomized trial. Proceedings: 44th Annual Scientific Sessions - American College of Cardiology, New Orleans, Louisiana, March 19-22, 1995. J Am Coll Cardiol 1995; 79A:710-2.

56) Weaver WD, Bode C, Burnett C, Kalbfleisch J, Lorch G, Sen S, Chernoff R,

Smalling R, RAPID 2 Trial Investigators. Reteplase vs. Alteplase Patency Investigation During Myocardial Infarction Trial (RAPID 2). Proceedings: 44th Annual Scientific Sessions - American College of Cardiology, New Orleans, Louisiana, March 19-22, 1995. J Am Coll Cardiol 1995;87A:715-5.

57) Feld S, Ganim M, Kelly R, Kjellgren O, Barasch E, Carell E, Lachterman B, Taus N,

Krishnaswami A, Kirkeeeide R, Anderson HV, Schroth G, Smalling RW. Predictive value of lesion characteristics on angioscopy and intravascular ultrasound on acute and long term outcome following coronary interventions. Proceedings: SCAI Meeting, Orlando, Florida, May, 1995. Cathet Cardiovasc Diagn 1995; 35:81A.

58) Bode C, Smalling RW, Kalbfleisch J, Berg G, Odenheimer DJ, Bohm E, Weaver

WD, RAPID II Investigators. Randomized comparison of double bolus reteplase (t-PA) in patients with acute myocardial infarction (RAPID II). Proceedings: XVIIth Congress of the European Society of Cardiology, Amsterdam, The Netherlands, August 20-24, 1995. Eur Heart J, (Abst Suppl) 1995; 11:131.

59) Feld S, Ganim M, Vaughn WK, Kelly R, Kjellgren O, Carell E, Tauss N, Kirkeeide

RL, Anderson HV, Schroth G, Smalling RW. Utility of angioscopy and

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

intravascular ultrasound in predicting outcome following coronary intervention. Proceedings: 68th Scientific Sessions - American Heart Association, Anaheim, California, November 13-16, 1995. Circulation, Suppl I 1995; 92(8):I18(0082).

60) Leon M, Abu-Halawa S, Kirkeeide R, Ketha S, Jones L, Smalling R, Anderson HV.

Estrogen status relates favorably to coronary artery flow in women without significant coronary artery disease. Proceedings: 68th Scientific Sessions - American Heart Association, Anaheim, California, November 13-16, 1995. Circulation, Suppl I 1995; 92(8):I326(1552).

61) Ganim M, Lachterman B, Felli P, Amirian J, Feld S, Vaughn W, Smalling RW.

Transvalvular left ventricular assistance immediately prior to and throughout reperfusion after a two hour coronary occlusion reduces infarct size. Proceedings: 68th Scientific Sessions - American Heart Association, Anaheim, California, November 13-16, 1995. Circulation, Suppl I 1995; 92(8):I-458(2186).

62) Hanna GP, Kjellgren O, Feld S, Fife CE, Schroth G, Anderson HV, Smalling RW.

Assessment and follow-up of infrapopliteal transcatheter interventions in diabetic patients referred for amputation. Proceedings: American College of Cardiology, Orlando, Florida, March 24-27, 1996.

63) Fujise K, Pathan A, Ganim M, Kirkeeide R, Stuart Y, Smalling RW. Bubble at the

tip of stent delivery system of the Palmaz-Schatz stent improves its track ability to the target site. Proceedings: 19th Annual Meeting of the Society for Cardiac Angiography and Interventions, Colorado Springs, Colorado, May 14-19, 1996.

64) Pathan A, Fujise K, Ganim M, Steward Y, Kirkeeide R, Chuang A, Smalling RW.

Adjunctive stenting after rotational atherectomy achieves a larger final luminal diameter: Will bigger be better? Proceedings: 19 Annual Meeting of the Society for Cardiac Angiography and Interventions, Colorado Spring, Colorado, May 14-19, 1996.

65) Pathan A, Fujise K, Ganim M, Jeang M, Mullins J, Krajcer Z, Benrey J, Perin E,

Schroth G, Smalling R. Favorable long term outcome of subclavian artery stenting. Proceedings: 69

th Scientific Sessions - American Heart Association, New Orleans,

Louisiana, November 10-13, 1996. 66) Roberts R, Fromm R, Boudreaux A, Zimmerman J, Meyer D, Wun C, Davis B,

Smalling R, Habib G. Multi-center blinded trial utilizing multiple diagnostic markers to exclude myocardial infarction in patients presenting consecutively to the ER with chest pain. Proceedings: 69

th Scientific Sessions - American Heart

Association, New Orleans, Louisiana, November 10-13, 1996. 67) Weaver D, Smalling R, Bode C, Odenheimer D, Rapid 1&2 Investigators. Effects of

time to patency and quality of patency on LV function and survival after myocardial infarction: Results from the RAPID 1 & 2 Trials. Proceedings: 69

th Scientific

Sessions - American Heart Association, New Orleans, Louisiana, November 10-13, 1996.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

68) Fujise K, Ganim MS, Pathan RL, Kirkeeide RL, Steward Y, Schroth GW, Smalling

RW. Balloon to artery ratio, not inflation pressure, correlates with adequate Palmaz-Schatz deployment: Is high pressure inflation necessary? Proceedings: American College of Cardiology, Anaheim, California, March 16-19, 1997.

69) Pathan A, Wong P, Fujise K, Ganim M, Jeang MK, Mullins JA, Krajcer A, Benrey

JV, Perin EC, Schroth GW, Smalling RW. Comparison of the Palmaz stent and wall stent reconstruction of critical subclavian artery stenosis. Proceedings: American College of Cardiology, Anaheim, California, March 16-19, 1997.

70) Kirkeeide R, Beretta P, Smalling RW, Anderson HV, Schroth G, Gould LK:

Diagnostic content of digital coronary arteriograms is unaffected by 12:1 image compression. Proceedings: American College of Cardiology, Anaheim, California, March 16-19, 1997.

71) Pathan A, Ganim M, Wong P, Fujise K, Rojas E, Revana M, Anderson HV, Schroth

GW, Smalling RW. Reconstruction of long total superficial femoral artery occlusions using multiple wall stents. Proceedings: American College of Cardiology, Anaheim, California, March 16-19, 1997.

72) Ganim M, Wong R, Grover R, Chuang A, Pathan A, Fujise K, Kirkeeide RL,

Anderson HV, Schroth GW, Smalling RW. Superiority of coronary stenting compared to balloon angioplasty in acute myocardial infarction. Proceedings: American College of Cardiology, Anaheim, California, March 16-19, 1997.

73) Hanna GP, Yeh E, Beck P, Alfaro-Franco C, Amirian J, Felli P, Smalling RW.

Synthetic small molecule inhibitor of P, E and L selectin given just prior to reperfusion produces infarct salvage in a two hour canine coronary occlusion/reperfusion model. Proceedings: American College of Cardiology, Anaheim, California, March 16-19, 1997.

74) Bode C, Kohler B, Moser M, Nordt TL, Peter K, Schmittner M, Smalling RW.

Platelet function during and after thrombolytic therapy for acute myocardial infarction with Reteplase, Alteplase, or Streptokinase. Proceedings: American Heart Association, Orlando, Florida, November 9-12, 1997.

75) Miller JM, Ohman EM, Schildcrout JS, Smalling RW, Betriu A, Califf RM, Topol

EJ. Survival benefit of Abciximab administration during early rescue angioplasty: Analysis of 387 patients from the GUSTO-III Trial. Proceedings: American College of Cardiology, Atlanta, Georgia, March 29-April 1, 1998.

76) Fromm R, Meyer D, Boudreaux A, Zimmerman H, Wun C-C, Davis B, Smalling R,

Habib G, Robert R. Comparison of qualitative bedside and laboratory performed cardiac markers in patients with chest pain in the Emergency Department. Proceedings: American College of Cardiology, Atlanta, Georgia, March 29-April 1, 1998.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

77) Fromm R, Meyer D, Boudreaux A, Zimmerman, Wun C-C, Davis B, Smalling R, Habib G, Robert R. Positive serum markers in patients with chest pain in the emergency department have prognostic significance. Proceedings: American College of Cardiology, Atlanta, Georgia, March 29-April 1, 1998.

78) Hayase M, Oshima A, Cleman MW, Pepine CJ, Bailey SR, Shani J, Sarian RD,

Smalling RW, Oesterle SN, Yock PG, Fitzgerald PJ. Relation between target vessel revascularization and minimum stent area by intravascular ultrasound (CRUISE Trial). Proceedings: American College of Cardiology, Atlanta, Georgia, March 29-April 1, 1998.

79) Rosales OR, Schroth GW, Thiesssen M, Anderson HV, Fujise K, Smalling RW.

Primary angioplasty improves outcome in right ventricular infarction. Proceedings: American College of Cardiology, Atlanta, Georgia, March 29-April 1, 1998.

* 80) Smalling RW, Karlsberg RP, Weiner R, Ebersole DG, Thadani U, Bates E, Habib

GB, Moliterno D, Park YC, Freitag JJ. Liposomal PGE-1 adjunctive treatment for acute myocardial infarction: Final results of the LIFT Pilot Trial. Proceedings: American College of Cardiology, Atlanta, Georgia, March 29-April 1, 1998.

81) Hanna GP, Yhip P, Fujise K, Schroth GW, Rosales OR, Anderson HV, Smalling

RW. Intracoronary adenosine administered during rotational atherectomy of complex lesions in native coronary arteries reduces the incidence of ‘no reflow’ phenomenon. Proceedings: American College of Cardiology, Atlanta, Georgia, March 29-April 1, 1998.

* 82) Smalling RW, Denktas AE, Cafri CJ, Cohen AM, Maklad NF, Raval B, Rosales OR,

Ruiz CE. Abdominal aortic aneurysm repair by percutaneous implantation of uncovered wire mesh stents and coil embolization of the aneurysm. Proceedings: American College of Cardiology, New Orleans, Louisiana, March 7-10, 1999.

83) Cafri CJ, Denktas AE, Rosales O, Schroth G, Fujise K, Anderson HV, Richard W

Smalling. Real life experience with arterial sealing devices: Is manual pressure

obsolete? Proceedings: XXIst Congress of the European Society of Cardiology,

Barcelona, Spain, August 28-September 1, 1999.

84) Denktas AE, Cohen AM, Cafri CJ, Assali A, Sdringola S, Rhiner MA, Maklad NF,

Raval B, Schroth G, Anderson HV, Rosales OR, De La Guardia B, Smalling RW.

Comparison of abdominal aortic aneurysm repair by percutaneous implantation of

uncovered wire mesh stents and coil embolization of the aneurysm cavity in patients

with and without pre-existent thrombus. Proceedings: 49th

Annual Scientific

Sessions - American College of Cardiology, Anaheim, California, March 12-15,

2000.

85) Denktas AE, Cafri CJ, Mamdani ST, Rosales OR, Fujise K, Schroth G, Anderson

HV, Smalling RW. Do sealing devices after vascular interventions make a difference

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

in clinical practice? Proceedings: 49th

Annual Scientific Sessions - American

College of Cardiology, Anaheim, California, March 12-15, 2000.

86) Assali AR, Rosales O, Sdringola S, Ghani M, Denktas AE, Yepes A, Hanna GP,

Anderson HV, Schroth G, Fujise K, Smalling RW. Intracoronary adenosine

administered during percutaneous intervention in acute myocardial infarction

reduces the incidence of “No-Reflow” phenomenon. Proceedings: The Society for

Cardiac Angiography and Interventions 23rd

Annual Meeting, Charleston, South

Carolina, May 3-6, 2000.

87) Sdringola S, Assali AR, Ghani M, Yepes A, Denktas AE, De La Guardia B, Rosales

O, Anderson HV, Schroth G, Smalling RW. Adenosine use during aortocoronary

vein graft interventions reverses but does not prevent the slow - no reflow

phenomenon. Proceedings: The Society for Cardiac Angiography and Interventions

23rd

Annual Meeting, Charleston, South Carolina, May 3-6, 2000.

88) Assali AR, Moustapha A, Sdringola S, Salloum J, Ghani M, Saikia S, Hale S,

Schroth G, Rosales O, Anderson HV, Smalling RW. Delayed is better than early

elective intervention after acute myocardial infarction treated with thrombolytic

therapy. Proceedings: 50th Annual Scientific Sessions - American College of

Cardiology, Orlando, Florida, March 18-21, 2001. J Am Coll Cardiol 2001;

37:A340.

89) Achour H, Denktas AE, Assali A, Amirian J, Felli P, Buja M, Uthman M, Smalling

RW. Protective effects of adenosine on myocardial ischemia and reperfusion in the

dogs. Proceedings: 50th Annual Scientific Sessions, Orlando, Florida, March 18-21,

2001. J Am Coll Cardiol 2001; 37:A346.

90) Assali A, Sdringola S, Salloum J, Moustapha A, Ghani M, Schroth G, Anderson HV,

Smalling RW, Rosales O. Effect of Clopidogrel loading before percutaneous

coronary intervention in patients treated with glycoprotein IIb/IIIa inhibitors.

Proceedings: 50th Annual Scientific Sessions, Orlando, Florida, March 18-21, 2001.

J Am Coll Cardiol 2001; 37:A83.

91) Assali AR, Boccalandro F, Moustapha A, De La Guardia B, Awadalla H, Kirkeeide

R, Raval B, Smalling RW. Rotational angiography may be more accurate than

computer tomography for the evaluation of abdominal aortic aneurysm size and

configuration prior to placement of endovascular aortic graft prosthesis. Catheter

and Cardiovasc Interv 2001; 53(1):118.

92) Boccalandro F, Assali AR, Raval B, Smalling RW. Rotational aortogram:

Comparison with computer tomography scan for iliac and common femoral artery

evaluation in abdominal aortic aneurysms. Am J Cardiol 2001; September

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

88(5A):94G.

93) Assali AR, Moustapha A, Sdringola S, Salloum J, Ghani M, Saikia S, Hale S,

Schroth G, Rosales O, Anderson HV, Smalling RW. Delayed is better than early

elective intervention after acute myocardial infarction treated with thrombolytic

therapy. Proceedings: 50th Annual Scientific Session - American College of

Cardiology, Orlando, Florida, March 18-21, 2001. J Am Coll Cardiol 2001;

37:A340.

94) Boccalandro F, Assali A, De La Guardia B, Achour H, Raval B, Smalling RW. New

invasive imaging technique rotational aortogram: Comparison with computer

tomography for abdominal aortic aneurysm evaluation. Proceedings: 51st Annual

Scientific Session Atlanta, Georgia, March 17-20, 2002. J Am Coll Cardiol 2002;

39:A45.

95) Salloum JG, Assali AR, Moustapha AI, Ghani M, Saikia S, Schroth G, Anderson

HV, Fujise K, Rosales O, Smalling RW. Emergent aorto-coronary bypass surgery

after complicated PCI: From the cath lab to the operating room directly or to the

ICU first? Proceedings: SCAI 25th

Annual Meeting, Seattle, Washington, May 15-

18 2002. Catheter Cardiovasc Interv 2002; 56(1):121.

96) Moustapha A, Salloum J, Saikia S, Awadalla H, Schroth G, Assali AR, Smalling

RW, Anderson HV, Rosales O. Combined cutting balloon angioplasty and

intracoronary radiation is a safe and effective method for treatment of in-stent

restenosis. Proceedings: SCAI 25th

Annual Meeting, Seattle, Washington, May 15-

18 2002. Catheter Cardiovasc Interv 2002; 56(1):121.

97) Awadalla H, Salloum J, Moustapha A, Sdringola S, Fujise K, Assali AR, Anderson

HV, Schroth G, Smalling RW, Rosales O. Ostial in-stent restenotic lesions are not

associated with a higher 6-months target lesion revascularization rates following

cutting balloon atherectomy and brachytherapy. Proceedings: SCAI 25th

Annual

Meeting, Seattle, Washington, May 15-18 2002. Catheter Cardiovasc Interv 2002;

56(1):L122.

98) Moustapha A, Assali AR, Salloum J, Awadalla H, Sdringola S, Saikia S, Hale S,

Schroth G, Fujise K, Rosales O, Anderson HV, Smalling RW. Facilitated

percutaneous intervention with fibrinolytics and platelet glycoprotein IIb/IIIa

receptor blockers yields better in-hospital outcomes than primary intervention in

patients with myocardial infarction. Proceedings: SCAI 25th

Annual Meeting,

Seattle, Washington, May 15-18 2002. Catheter Cardiovasc Interv 2002; 56(1):123.

99) Boccalandro F, Ahmed M, Achour H, Smalling RW. Evaluation of the external

iliac and common femoral anatomy in patients with abdominal aortic aneurysm

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

before endovascular exclusion stent placement: Rotational aortogram vs. computer

tomography. Proceedings: SCAI 25th

Annual Meeting, Seattle, Washington, May

15-18 2002. Catheter Cardiovasc Interv 2002; 56(1):123.

100) Ghani M, Awadalla H, Carter C, Butler C, Smalling RW. Percutaneous closure of

patent foramen ovale with transcatheter occlusion device: Is it safe and efficacious?

Proceedings: SCAI 25th

Annual Meeting, Seattle, Washington, May 15-18 2002.

Catheter Cardiovasc Interv 2002; 56(1):138.

101) Li Q, Anderson HV, Fuentes F, Fujise K, Schroth G, Sdringola S, Rosales OR,

Smalling RW. Is anomalous origin of coronary arteries associated with

atherosclerosis? Proceedings: SCAI 25th

Annual Meeting, Seattle, Washington, May

15-18 2002. Catheter Cardiovasc Interv 2002; 56(1):140.

102) Awadalla H, Salloum J, Moustapha A, Sdringola S, Fujise K, Assali AR, Rosales O,

Anderson HV, Schroth G, Smalling RW. Rheolytic thrombectomy does not prevent

slow-, no-reflow during percutaneous coronary intervention in acute myocardial

infarction. Proceedings: SCAI 25th

Annual Meeting, Seattle, Washington, May 15-

18 2002. Catheter Cardiovasc Interv 2002; 56(1):141.

103) Boccalandro F, Baptista E, Achour H, Carter C, Underwood C, Smalling RW.

Covered stents versus bare metal stents with trans-stent coil embolization for

endovascular abdominal aortic repair. Proceedings: Transcatheter Cardiovascular

Therapeutics, Washington, DC, 2002. Am J Cardiol 2002 September; TCT-78.

104) Salloum J, Huynh T, Achour H, Felli P, Amirian J, Cannon A-M, Smalling RW.

Percutaneous abdominal aortic aneurysm exclusion in a pig model with facilitation

of collagen deposition by biocompatible foam plugs. Proceedings: Transcatheter

Cardiovascular Therapeutics, Washington, DC, 2002. Am J Cardiol 2002

September; TCT-146.

105) Boccalandro F, Baptista E, Carter C, Butler C, Barasch E, Smalling RW.

Comparison of interatrial defect sizing by intracardiac versus transesophageal

echocardiography. Proceedings: Transcatheter Cardiovascular Therapeutics,

Washington, DC, 2002. Am J Cardiol 2002 September; TCT-353.

106) Boccalandro F, Ahmad M, Sdringola S, Baptista E, Smalling RW. Oral

acetylcysteine does not prevent induced nephropathy in patients with chronic renal

insufficiency undergoing cardiac catheterization. Proceedings: American Heart

Association, Chicago, Illinois, 2002.

107) Boccalandro F, Baptista E, Carter C, Butler C, Barasch E, Smalling RW.

Intracardiac echocardiography guidance for transcatheter closure of inter-arterial

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

defects. A comparison study with transesophageal echocardiography. Proceedings:

American Heart Association, Chicago, Illinois, 2002.

108) Boccalandro F, Baptista E, Muench A, Carter C, Campbell M, Smalling RW.

Carotid stenting with intravenous abciximab is a safe and efficacious strategy

compared with carotid endarterectomy. Proceedings: 52nd Annual Scientific

Sessions, Chicago, Illinois, March 30-April 2, 2003. J Am Coll Cardiol 2003;

41:A51.

109) Boccalandro F, Baptista E, Muench A, Carter C, Campbell M, Smalling RW.

Carotid stenting with intravenous abciximab is a safe and efficacious strategy

compared with carotid endarterectomy. Proceedings: 52nd Annual Scientific

Sessions, Chicago, Illinois, March 30-April 2, 2003. J Am Coll Cardiol 2003;

41:A51.

110) Hong T, Hijazi ZM, Hagler DJ, Patel H, Cheatham JP, Satler L, SmallingRW.

Results of U.S. phase I clinical trial of closure of patent foramen ovale sssociated

with stroke/transient ischemic attack or peripheral embolism using the amplatzer

patent foramen ovale device. Proceedings: 52nd Annual Scientific Sessions,

Chicago, Illinois, March 30-April 2, 2003. J Am Coll Cardiol 2003; 41:A75.

111) Assali AR, Moustapha A, Awadalla H, Salloum JG, McClelland R, Smalling RW.

A higher vascular injury index is associated with a higher incidence of in-stent

restenosis: Insights from the PRESTO trial. Proceedings: 52nd Annual Scientific

Sessions, Chicago, Illinois, March 30-April 2, 2003. J Am Coll Cardiol 2003;

41:A78.

112) Boccalandro F, Achour HC, Muench A, Kirkeeide R, Smalling RW. Accuracy of

aortic valve area calculation using a computer-based planimetry system in the

catheterization laboratory. Proceedings: 52nd Annual Scientific Sessions, Chicago,

Illinois, March 30-April 2, 2003. J Am Coll Cardiol 2003; 41:A520.

113) Achour HC, Boccolandro F, Felli P, Amirian J, Smalling RW. Mechanical left

ventricular unloading immediately prior to reperfusion reduces infarct size.

Proceedings: 52nd Annual Scientific Sessions, Chicago, Illinois, March 30-April 2,

2003. J Am Coll Cardiol 2003; 41:A354.

114) Boccalandro F, Baptista E, Carter C, Smalling RW. Percutaneous transcatheter

closure of patent foramen ovale with the cardioseal device for secondary prevention

of ischemic neurological events. Proceedings: SCAI 26th

Annual Scientific Sessions,

Boston, Massachussetts, May 7-10, 2003. Catheter Cardiovasc Interv 2003;

59(1):111.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

115) Boccalandro F, Iliescu C, Achour H, Kirkeeide R, Sdringola S, Smalling RW.

Accuracy of mitral valve area calculation using a computer based planimetry system

in the catheterization laboratory. Proceedings: SCAI 26th

Annual Scientific

Sessions, Boston, Massachussetts, May 7-10, 2003. Catheter Cardiovasc Interv

2003; 59(1):112.

116) Boccalandro F, Iliescu C, Carter C, Smalling RW. Chest x-ray characteristics of

inter- atrial closure devices in the adult. Proceedings: SCAI 26th

Annual Scientific

Sessions, Boston, Massachussetts, May 7-10, 2003. Catheter Cardiovasc Interv

2003; 59(1):112.

117) Boccalandro F, Baptista E, Carter C, Smalling RW. Does inter-atrial septal

aneursyms jeopardize successful percutaneous transcatheter closure of patent

foramen ovale? Proceedings: SCAI 26th

Annual Scientific Sessions, Boston,

Massachussetts, May 7-10, 2003. Catheter Cardiovasc Interv 2003; 59(1):112.

118) Boccalandro F, Baptista E, Carter C, Butler C, McMullin J, Smalling RW. Use of

intracardiac and transesophageal echocardiography for inter-atrial defect sizing.

Proceedings: SCAI 26th

Annual Scientific Sessions, Boston, Massachussetts, May 7-

10, 2003. Catheter Cardiovasc Interv 2003; 59(1):113.

119) Boccalandro F, Muench A, Hale S, Smalling RW, Sdringola S. Performance of a

new coronary power injector for diagnostic angiography and percutaneous

interventions. Proceedings: SCAI 26th

Annual Scientific Sessions, Boston,

Massachussetts, May 7-10, 2003. Catheter Cardiovasc Interv 2003; 59(1):116.

120) Boccalandro F, Fujise K, Hale S, Smalling RW, Sdringola S. Outcomes of vascular

access site with the use of closure devices in patients treated with glycoprotein

IIb/IIIa inhibitors during rescue angioplasty. Proceedings: SCAI 26th

Annual

Scientific Sessions, Boston, Massachussetts, May 7-10, 2003. Catheter Cardiovasc

Interv 2003; 59(1):137.

121) Achour HC, Boccalandro F, Buja ML, Geng YJ, Amirian J, Felli P, Smalling RW.

Effects of mechanical left ventricular unloading on endothelin-1 release and

apoptosis. Proceedings: 53rd Annual Scientific Sessions, New Orleans, Louisiana,

March 7–10, 2004. J Am Coll Cardiol 2004; 44:A263-264.

122) Heuser R, Kirvaitis R, Braden GA, Gammon RS, Teirstein PA, Moses JW, Smalling

RW, Schaer GL, Reisman M, Raybuck BA, Power JA, Baim DS. Fiberoptic

guidance system for the treatment of chronic total occlusion: The results of the

GREAT registry (Guided Radiofrequency Energy Ablation of Total Occlusions).

Proceedings: SCAI 27th

Annual Scientific Sessions, San Diego, California, April 28

– May 1, 2004. Catheter Cardiovasc Interv 2004; 62(1):115.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

123) Boccalandro F, Murtagh B, Pipitone T, Carter C, Underwood C, Smalling RW.

Comparison of the ancure and aneurx endografts for abdominal aortic aneurysm

endovascular repair in patients unsuitable for open surgical repair. Proceedings:

SCAI 27th

Annual Scientific Sessions, San Diego, California, April 28 – May 1,

2004. Catheter Cardiovasc Interv 2004; 62(1):104.

124) Ellis K, Boccalandro F, Burjonroppa S, Muench A, Smalling RW, Sdringola S.

Bleeding complications and outcomes using glycoprotein IIB/IIIA inhibitors in

rescue angioplasty compared with primary percutaneous coronary intervention for

acute myocardial infarction. Proceedings: SCAI 27th

Annual Scientific Sessions,

San Diego, California, April 28 – May 1, 2004. Catheter Cardiovasc Interv 2004;

62(1):118.

125) Boccalandro F, Ellis K, Muench A, Anderson HV, Smalling RW, Sdringola S.

Vascular access site outcomes with the use of closure devices in patients with

platelet glycoprotein IIB/IIIA inhibitors during rescue angioplasty. Proceedings:

SCAI 27th

Annual Scientific Sessions, San Diego, California, April 28 – May 1,

2004. Catheter Cardiovasc Interv 2004; 62(1):136.

126) Giesler GM, Vooletich M, Julapalli V, et al. Coordinated aggressive medical and

interventional therapy for acute myocardial infarction: Pre-hospital administration of

thrombolysis with urgent culprit artery revascularization (PATCAR). Am J Cardiol

Suppl 1, 2005 October 3; 96(7):56H.

127) Iliescu C, Giesler GM, Hemstreet P, Liu W, Murtagh B, Fuentes F, Anderson HV,

Denktas AE, Smalling RW. Natural catastrophic events are associated with

increased incidence and severity of acute coronary syndromes. Proceedings:

American College of Cardiology, Atlanta, Georgia, March 11-14, 2006.

128) Shaik N, Butkevich A, Iliescu C, Croitoru M. Cause of death and serum cardiac

Troponin levels predict cardiac function in heart transplant donors. American

College of Cardiology Atlanta, Georgia, March 11-14, 2006.

129) Giesler GM, Sdringola S, Vooletich M, Julapalli V, Anderson HV, Denktas AE,

Persse D, Smalling RW. Coordinated aggressive medical and interventional therapy

for acute myocardial infarction: Pre-hospital administration of thrombolysis with

urgent culprit artery revascularization (PATCAR). Proceedings: World Congress of

Cardiology 2006, September 2-6, 2006.

130) Ledoux J. Effect of treatment time and infarct location on infarct size in patients

treated with early pre-hospital thrombolytic therapy. Proceedings: Transcatheter

Cardiovascular Therapuetics, Washington, DC, October 2006.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

131) Abbas A, Gulbis B, Hall A, Liu W, Landrau C, Reyes M, Pham C, Kaynak H,

McCarthy J, Persse D, Sdringola S, Anderson H, Smalling RW, Denktas A.

Integrated approach to the treatment of sudden cardiac death improves survival in an

urban setting. J Am Coll Cardiol (Abstract #1019-196) 2007; 49(9):230 A.

132) Hall A, Gulbis B, Abbas A, Liu W, Landrau C, Reyes M, Pham C, Kaynak H,

McCarthy J, Persse D, Sdringola S, Anderson H, Smalling RW, Denktas A.

Therapeutic hypothermia for out-of-hospital cardiac arrest may not improve survival

when utilized in an unselected population. J Am Coll Cardiol (Abstract #1025-196)

2007; 49(9): 246 A.

133) Iliescu C, Huff J, Denktas AD, Vooletich MT, Smalling RW, Sdringola S. Low

socio-economic status is associated with subacute and late drug eluting stent

thrombosis. Cath Cardiovasc Inter 2007 May; 69(6).

134) Iliescu C, Loghin C, Smalling RW, Siddiqui H, Sdringola S. Identifying young

women at high risk of significant angiographic coronary artery disease. Cath

Cardiovasc Inter 2007 May; 69(6).

135) Anderson H, Denktas A, Sdringola, S, Smalling RW, Fuentes F, Ashrith, G, Loghin,

C, Letsou, G. Left ventricular function improves early after “off pump” coronary

bypass (OPCAB) surgery. Proceedings: 13th

World Congress on Heart Disease, The

International Academy of Cardiology Annual Scientific Sessions 2007, Vancouver,

BC, Canada, July 28-31, 2007.

136) Emelianov S, Sethuraman S, Wang B, Litovsky SH, Smalling RW. Intravascular

ultrasound and photoacoustic imaging. Proceedings: Biomedical Engineering

Society 2007 Annual Fall Meeting, Los Angeles, California, September 26-29, 2007.

137) Tamareille S, Amirian J, Felli P, Li F, Barry WH, Smalling RW. Endothelin-1

receptor blockade and left ventricular unloading immediately prior to reperfusion

result in equivalent myocardial salvage compared to reperfusion alone in a rabbit

myocardial infarction model. Proceedings: 57th

Annual Scientific Sessions -

American College of Cardiology, Chicago, Illinois, March 29 - April 2, 2008. J Am

Coll Cardiol Suppl l1, 2008; 51: A180: 1003-49.

138) Iliescu C, Amirian J, Litovsky S, Wang B, Aglyamov S, Hamilton A, Emelianov S,

Smalling RW. Intravascular imaging using combined intravascular ultrasound and

photoacoustic catheters in a rabbit atherosclerotic model. Proceedings: American

College of Cardiology Scientific Sessions, Chicago, Illinois, March 29-31, 2008.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

139) Bhalla K, Sanon S, Smalling RW, Denktas A. Septal ablation using detachable coils

may be a useful alternative for the treatment of patients with symptomatic

hypertrophic obstructive cardiomyopathy. Proceedings: Transcatheter

Cardiovascular Therapeutics Conference, Washington, DC, October 12-17, 2008.

140) Emelianov S, Wang B, Su J, Karpiouk A, Yantsen E, Sokolov K, Amirian J,

Smalling R, Sethuraman S. Intravascular ultrasound and photoacoustic imaging.

Proceedings: Annual International Conference of the IEEE Engineering in Medicine

and Biology Society Conference, Vancouver, Canada, August 21-24, 2008.

141) Kar S, Whitlow P, Pederson W, Lim S, Kipperman R, Smalling R, Bajwa T,

Hermann H, Lasala J, Kramer P, Maddux JT, Feldman T, Glower D, Carabello BA,

Foster E. Successful Mitraclip® therapy results in favorable septo-lateral mitral

annular diameter and left ventricular remodeling in high risk surgical patients with

functional mitral regurgitation. Proceedings: Transcatheter Cardiovascular

Therapeutics Conference, San Francisco, California, September 21-25, 2009.

142) Thaler DE, Book DS, Carroll JD, Goldstein LB, Lutsep HL, Saver JL, Smalling RW,

Tirschwell DL, Van Dorn BM, The RESPECT Trial Investigators. Risk profile of

subjects enrolled in the randomized evaluation of recurrent stroke comparing PFO

closure to established current standard of care treatment (RESPECT) trial over the

first six years of enrollment. Proceedings: American Academy of Neurology 62nd

Annual Meeting, Toronto, Ontario, Canada, April 10-17, 2010. * Presenter PUBLICATIONS (Scientific): 1) Malkin S, Wiggins KL, Osman M, Smalling RW. Size effects in abrasive processes.

Proceedings: Thirteenth International Machine and Tool Design and Research Conference, Birmingham, England, MacMillan Press 1973; Limited:291.

2) Geddes LA, Bourland JD, Smalling RW, Steinberg RB. Recording skin resistance

and beat-by-beat heart rate from the same pair of electrodes. Psychophysiology 1974; 11(3):394-97.

3) Smalling RW, Meyers D, Skolnick M, Shabetai R, Cole JS, Johnston D: Automated

scanning and analysis of ventricular cine angiograms. Proceedings: Society of Photo-Optical Instrumentation Engineers 1975; 47:176.

4) Geddes LA, Bourland JD, Smalling RW, Steinberg RB. The use of the same pair of

dry electrodes to record skin resistance and beat-by-beat heart rate. Med Biol Eng 1975; 13(1):89-96.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

5) Smalling RW, Skolnick MH, Meyers D, Shabetai R, Cole JS, Johnston DA. Digital boundary detection, volumetric and wall motion analysis of left ventricular cine angiograms. Comput Biol Med 1976; 6(1):73-85.

6) Meaney E, Shabetai R, Bhargava VI, Shearer M, Weidner C, Manigardi LM,

Smalling RW, Peterson K. Cardiac amyloidosis, constrictive pericarditis and restrictive cardiomyopathy. Am J Cardiol 1976; 38(5):547-56.

7) Smalling RW, Cole JS, Skolnick MH. Comparison of digital boundary detection and

semi-automated analysis of left ventricular cine angiograms. Cathet Cardiovasc Diagn 1979; 5(4):331-46.

8) Reduto LA, Smalling RW, Freund GC, Gould KL. Intracoronary infusion of

streptokinase in patients with acute myocardial infarction: effects of reperfusion upon left ventricular performance. Am J Cardiol 1981; 48(3):403-09.

9) Reduto LA, Freund GC, Gaeta JM, Smalling RW, Lewis B, Gould KL. Coronary

artery reperfusion in acute myocardial infarction: Beneficial effects of intracoronary streptokinase on left ventricular salvage and performance. Am Heart J 1981; 102 (6 Pt 2):1168-77.

10) Smalling RW, Fuentes F, Freund GC, Reduto LA, Wanta-Matthews M, Gaeta JM,

Walker W, Sterling R, Gould KL. Beneficial effects of intracoronary thrombolysis up to eighteen hours after onset of pain in evolving myocardial infarction. Am Heart J 1982; 104(4 Pt 2):912-20.

11) Walker WE, Smalling RW, Sterling RP, DuBose RK, Fuentes F, Reduto LA, Gould

KL. Experience with streptokinase reperfusion and early surgical revascularization in patients with acute myocardial infarction. South Med J 1982; 75(12):1531-33, 1537.

12) Kirkeeide RL, Smalling RW, Gould KL. Automated evaluation of vessel diameter

from coronary arteriograms. Proceedings: IEEE Computers in Cardiology 1982; 215.

13) Smalling RW. A rational approach to the use of calcium antagonists. The Medical

Journal of St. Joseph Hospital 1982; 17:167. 14) Fuentes F, Smalling RW, Gould KL. Lysis of coronary thrombus with streptokinase

in acute myocardial infarction. Bull Soc Intern Med 1982; 3:9. 15) Smalling RW, Fuentes F, Matthews MW, Freund GC, Hicks CH, Reduto LA,

Walker WE, Sterling RP, Gould KL. Sustained improvement in left ventricular function and mortality by intracoronary streptokinase administration during evolving myocardial infarction. Circulation 1983; 68(1):131-38.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

16) Smalling RW, Fuentes F, Freund GC, Reduto LA, Matthews M, Gaeta J, Walker W, Sterling R, Gould KL. Metabolic and functional improvement with intracoronary thrombolysis in evolving myocardial infarction. Vascular Medicine 1983; 1:86.

17) Fuentes F, Smalling RW, Freund, GC, Wanta-Matthews M, Reduto LA, Gould KL.

New therapy for acute myocardial infarction: intracoronary thrombolysis. Tex Med 1983; 79(1):51-4.

18) Fuentes F, Smalling RW, Reduto LA, Freund GC, Gould KL. Lysis of coronary

thrombus with streptokinase. Bulletin International Symposium on Fibrinolytic Therapy 1983; 485, F. K. Schattauer Verlag, Stuttgart - New York.

19) Smalling RW. The SPECTrum of thallium-201 imaging in coronary artery disease.

J Nucl Med (Teaching Editorial) 1983; 24(9):854-58. 20) Naccarelli GV, Smalling RW, Goldstein RA. Newer approaches and treatment of

myocardial infarction, arrhythmias and the failing heart. Houston Heart Bulletin 1983; 3:1.

21) Smalling RW, Kelley KO, Kirkeeide RL, Gould KL. Comparison of early systolic

and early diastolic regional function during regional ischemia in a chronically instrumented canine model. J Am Coll Cardiol 1983; 2(2):263-69.

22) Walker WE, Smalling RW, Fuentes F, Gould KL, Johnson WE, Reduto LA, Sterling

RP, Weiland AP, Wynn MM. Role of coronary artery bypass surgery after intracoronary streptokinase infusion for myocardial infarction. Am Heart J 1984; 107(4):826-29.

23) Sterling RP, Walker WE, Weiland AP, Freund GC, Fuentes F, Gould KL, Smalling

RW. Early bypass grafting following intracoronary thrombolysis with streptokinase. J Thorac Cardiovasc Surg 1984; 87(4):487-92.

24) Smalling RW, Gould KL. Cardiovascular imaging: ischemia and reperfusion. Hosp

Pract (Off Ed) 1984; 19(3):163-85. 25) Fuentes F, Walker WM, Bailey WP, Smalling RW, Gould KL. Post infarction

ventricular septal rupture and cardiogenic shock. Primary Cardiology 1984; 46. 26) Smalling RW, Kelley K, Kirkeeide RL, Fisher DJ. Regional myocardial function is

not affected by severe coronary depressurization provided coronary blood flow is maintained. J Am Coll Cardiol 1985; 5(4):948-55.

27) Lin FK, Suggs S, Lin CH, Browne JK, Smalling RW, Egrie JC, Chen KK, Fox GM,

Martin F, Stabinsky Z. Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci USA 1985; 82(22):7580-84.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

28) Hu S, Bruszewski J, Smalling RW, Browne JK. Studies of TGEV spike protein gp195 expressed in E. coli and by a TGE-vaccinia virus recombinant. Adv Exp Med Biol 1985; 185:63-82.

29) Weiland AP, Daskal Y, Kerman R, Smalling RW, Williams JP, Walker WE. Aids

prodrome in an apparently normal man following coronary artery bypass: New significance of postoperative bleeding. Tex Heart Inst J 1985; 12(2):195-97.

30) Smalling RW, Fuentes FF, Hicks C, Matthews MW, Kuhn J, Freund GC, Gould KL.

Risk/benefit analysis of intracoronary thrombolytic therapy in evolving myocardial infarction. The European Society of Cardiology (Suppl E) 1985; 6:217.

31) Smalling RW, Kelley K, Fisher DJ. Regional myocardial function and coronary

blood flow. Cardiovascular Board Review 1985; 2(5):21-24. 32) Gould KL, Goldstein RA, Mullani NA, Kirkeeide RL, Wong WH, Tewson TJ,

Berridge MS, Bolomey LA, Hartz RK, Smalling RW, Fuentes F, Nishikawa A. Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VIII. Clinical feasibility of positron cardiac imaging without a cyclotron using generator-produced rubidium-82. J Am Coll Cardiol 1986; 7(4):775-89.

33) Smalling RW. Changes in ventricular function associated with coronary reperfusion

in acute myocardial infarction. Herz 1986; 11(1):26-32. 34) Lin FK, Lin CH, Lai PH, Browne JK, Egrie JC, Smalling RW, Fox GM, Chen KK,

Castro M, Suggs S. Monkey erythropoietin gene: cloning, expression and comparison with the human erythropoietin gene. Gene 1986; 44(2-3):201-09.

35) Freedman RJ Jr., Fuentes F, Smalling RW, Kirkeeide RL, Sterling RP, Walker WE,

Gould KL. Left coronary artery spasm causing severe left ventricular dysfunction without myocardial infarction. Texas Heart Inst J 1986; 13(2):223-31.

36) Egrie JC, Strickland TW, Lane J, Aoki K, Cohen AM, Smalling RW, Trail G, Lin

FK, Browne JK, Hines DK. Characterization and biological effects of recombinant human erythropoietin. Immunobiology 1986; 172(3-5):213-24.

37) Smalling RW, Ekas RD, Felli PR, Binion L, Desmond J. Reciprocal functional

interaction of adjacent myocardial segments during regional ischemia: an intraventricular loading phenomenon affecting apparent regional contractile function in the intact heart. J Am Coll Cardiol 1986; 7(6):1335-46.

38) Smalling RW. Improvement in regional function by synchronized coronary sinus

retroperfusion during acute LAD ischemia. International Working Group on Coronary Sinus Interventions 1986; 1(1):5.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

39) Goldstein RA, Mullani NA, Wong WH, Hartz RK, Hicks CH, Fuentes F, Smalling RW, Gould KL. Positron imaging of myocardial infarction with Rubidium-82. J Nucl Med 1986; 27(12):1824-29.

40) Smalling RW, Fuentes F, Matthews MW, Kuhn J, Nishikawa A, Walker WE, Adams

PR, Gould KL. Factors affecting outcome of coronary reperfusion with intracoronary streptokinase in acute myocardial infarction. Am J Cardiol 1987; 59(6):505-12.

41) Topol EJ, Morris DC, Smalling RW, Schumacher RR, Taylor CR, Nishikawa A,

Liberman HA, Collen D, Tufte ME, Grossbard EB. A multicenter, randomized, placebo-controlled trial of a new form of intravenous recombinant tissue-type plasminogen activator (Activase) in acute myocardial infarction. J Am Coll Cardiol 1987; 9(6):1205-13.

42) Smalling RW. Can the immediate efficacy of coronary angioplasty be adequately

assessed? J Am Coll Cardiol 1987; 10(2):261-63. 43) Goldstein RA, Kirkeeide RL, Smalling RW, Nishikawa A, Merhige ME, Demer LL,

Mullani NA, Gould KL. Changes in myocardial perfusion reserve after PTCA: non-invasive assessment with positron tomography. J Nucl Med 1987; 28(8):1262-67.

44) Lorber MI, Van Buren CT, Flechner SM, Cameron L, Leatherwood J, Walker WE,

Smalling RW, Kahan BD. The effect of pretransplant diagnosis and therapy of coronary artery disease upon mortality following renal transplantation in diabetes mellitus. Transplant P 1987; 19(1 Pt 2):1539-41.

45) Demer LL, Buchi M, Nishikawa A, Smalling RW, Gould KL. The use of pressure-

volume curves to assess the mechanism and adequacy of stenosis dilation by balloon angioplasty. Proceedings: Symposium on Intravascular and Intracardiac Interventional Therapy: Techniques and Instruments, Freiburg, Germany. Z Kardiol 1987; 76 Suppl 6:37-41.

46) Goldstein RA, Kirkeeide RL, Demer LL, Merhige M, Nishikawa A, Smalling RW,

Mullani NA, Gould KL. Relation between geometric dimensions of coronary artery stenoses and myocardial perfusion reserve in man. J Clin Invest 1987; 79(5):1473-78.

47) Cassidy DB, Smalling RW. Acute MI: role of thrombolysis and intervention. Crit

Care Clin 1989; 5(3):435-53. 48) Demer LL, Gould KL, Goldstein RA, Kirkeeide RL, Mullani NA, Smalling RW,

Nishikawa A, Merhige ME. Assessment of coronary artery disease severity by positron emission tomography: Comparison with quantitative arteriography in 193 patients. Circulation 1989; 79(4):825-35.

49) Merhige ME, Smalling RW, Cassidy DB, Barrett R, Wise G, Short J, Wampler RK.

Effect of the hemopump left ventricular assist device on regional myocardial

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

perfusion and function: Reduction of ischemia during coronary occlusion. Circulation 1989; 80 (5 Pt 2)(Suppl III):158-66.

50) Smalling RW, Schumacher R, Morris D, Harder K, Fuentes F, Valentine RP, Battey

LL, Merhige M, Pitts DE, Lieberman HA, Nishikawa A, Adyanthaya A, Hopkins A, Grossbard E. Improved infarct-related arterial patency after high dose, weight-adjusted, rapid infusion of tissue-type plasminogen activator in myocardial infarction: results of a multicenter randomized trial of two dosage regimens. J Am Coll Cardiol 1990; 15(5):915-21.

51) Cassidy DB, Smalling RW. Mechanical left ventricular support devices: current

status. Indian Heart J 1990; 42(1):1-7. 52) Smalling RW. Thrombolysis in acute MI: Techniques, strategies, and promising

concomitant therapy. Illustrated Medicine 1990; 5(4). 53) Gould KL, Yoshida K, Hess MJ, Haynie M, Mullani N, Smalling RW. Myocardial

metabolism of fluorodeoxyglucose compared to cell membrane integrity for the potassium analogue rubidium-82 for assessing infarct size in man by PET. J Nucl Med 1991; 32(1):1-9.

54) Wampler RK, Frazier OH, Lansing AM, Smalling RW, Nicklas JM, Phillips SJ,

Guyton RA, Golding LA. Treatment of cardiogenic shock with the hemopump left ventricular assist device. Ann Thorac Surg 1991; 52(3):506-13.

55) Fleming RM, Kirkeeide RL, Smalling RW, Gould KL. Patterns in visual

interpretation of coronary arteriograms as detected by quantitative coronary arteriography. J Am Coll Cardiol 1991; 18(4):945-51.

56) Smalling RW. The hemopump: A transvalvular, axial flow, left ventricular assist

device. Coronary Artery Disease 1991; 2 (6):667-71. 57) Gauthier J, Smalling RW, Wu AHB, Buja LM. A clinicopathologic conference:

Severe anginal pain in a 58-year-old man. Houston Medicine 1991; 7:58-69. 58) Smalling RW, Cassidy DB, Schmidt WA, Barrett R, Fulford S, Kirkeeide RL.

Effects of rotational atherectomy in normal canine coronary and diseased human cadaveric arteries: potential for plaque removal from distal, tortuous, and diffusely diseased vessels. Cathet Cardiovasc Diagn 1991; 24(4):300-07.

59) Smalling RW. The use of mechanical assist devices in the management of

cardiogenic shock secondary to acute myocardial infarction. Secondary to acute myocardial infarction. Tex Heart Inst J 1991; 18(4):275-81.

60) Smalling RW, Cassidy DB, Barrett R, Lachterman B, Felli P, Amirian J. Improved

regional myocardial blood flow, left ventricular unloading, and infarct salvage using an axial-flow, transvalvular left ventricular assist device: a comparison with intra-

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

aortic balloon counterpulsation and reperfusion alone in a canine infarction model. Circulation 1992; 85(3):1152-59.

61) Smalling RW. Redoubtable restenosis. Circulation (Editorial Comment) 1992;

86(1):325-27. 62) Li G, Nguyen L, Smalling RW. Peripheral percutaneous aspiration thrombectomy

and angioplasty following failed lytic therapy for acute popliteal artery occlusion. J Interv Cardiol 1992; 5:159-62.

63) Smalling RW. Cardiac emergencies in the cancer patient (The Gibbs et al article

reviewed). Oncology 1992; 6(10):29-30. 64) Anderson HV, Kirkeeide RL, Stuart Y, Smalling RW, Heibig J, Willerson JT.

Coronary artery flow monitoring following coronary interventions. Am J Cardiol 1993; (Suppl.) 71(14):62D-69D.

65) Rosales OR, Hess MJ, Heibig J, Smalling RW. Percutaneous transluminal balloon

aortic and mitral valvuloplasty in 27 patients treated at Hermann Hospital. J Texas Medicine 1993; 89(8):60-68.

66) Keller P, Smalling RW. Granulocyte colony stimulating factor: animal studies for

risk assessment. Int Rev Exp Pathol 1993; 34 Pt A: 173-88. 67) Scholz KH, Figulla HR, Schweda F, Smalling RW, Hellige G, Kreuzer H, Aboul-

Hosn W, Wampler RK. Mechanical left ventricular unloading during high risk coronary angioplasty: first use of a new percutaneous transvalvular left ventricular assist device. Cathet Cardiovasc Diagn 1994; 31(1):61-69.

68) Hutchinson SJ, Smalling RW, Albornoz M, Colletti P, Tak T, Chandraratna PA.

Comparison of transthoracic and transesophageal echocardiography in clinically overt or suspected pericardial heart disease. Am J Cardiol 1994; 74(9):962-65.

69) Hutchinson SJ, Smalling RW, Ma A, Tubau JF, Kawanishi DT, Tak T, Rahimtoola

SH, Chandraratna PA. Transthoracic and transesophageal echocardiography pre and post percutaneous mitral catheter balloon valvulotomy. J Heart Valve Dis 1994; 3(2):149-54.

70) Smalling RW, Sweeney M, Lachterman B, Hess MJ, Morris R, Anderson HV,

Heibig J, Li G, Willerson JT, Frazier OH, Wampler RK. Transvalvular left ventricular assistance in cardiogenic shock secondary to acute myocardial infarction: evidence for recovery from near fatal myocardial stunning. J Am Coll Cardiol 1994; 23(3):637-44.

71) Feld S, Ekas RD, Felli P, Amirian J, Smalling RW. Differential effects of

synchronized coronary sinus retroperfusion on regional myocardial function during brief occlusion of the left anterior descending and circumflex arteries. Cathet Cardiovasc Diagn 1994; 32(1):70-78.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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72) Block PC, Smalling RW, Owings RM. Percutaneous double balloon valvotomy for

bioprosthetic tricuspid stenosis. Cathet Cardiovasc Diagn 1994; 33(4):342-44. 73) Smalling RW, Chen P, Buja LM. A 56-year-old man with acute-onset pulmonary

edema and shock. Proceedings: Clinicopathological Conference at The University of Texas Medical School at Houston on January 31, 1994. Circulation 1994; 89(6):2921-27. French translation published in Cardinale Revue de Cardiologie.

74) Anderson HV, Kirkeeide RL, Willerson JT, Mishkel DC, Kjellgren O, Smalling RW,

Schroth G. Coronary artery flow monitoring following coronary interventions. Am J Cardiol 1994 May 20; 71(14):62D-69D.

75) Smalling RW. Transstenotic pressures: can there be a "low-tech" solution to a

complex physiologic problem? Cathet Cardiovasc Diagn 1994 Nov; 33(3):262-3. 76) Turrentine MA, Smalling RW, Parisi VM. Right atrial thrombus as a complication

of total parenteral nutrition in pregnancy. Obstet Gynecol 1994; 84(4 Pt 2):675-77. 77) Feld S, Li G, Amirian J, Felli P, Vaughn WK, Accad M, Tolleson T, Swenson C,

Ostro M, Smalling RW. Enhanced thrombolysis, reduced coronary reocclusion and limitation of infarct size with liposomal prostaglandin E1 in a canine thrombolysis model. J Am Coll Cardiol 1994 November; 24(5):1382-90.

78) Smalling RW: Quantification of intracoronary volume by video densitometry: A

validation study using fluid filling of human coronary casts. Cathet Cardiovasc Diagn (Editorial Comment) 1994; 33:95.

79) Smalling RW, SooHoo W, Chen P. A 25-year-old white woman with a

cerebrovascular accident and a right-to-left shunt. Proceedings: Clinicopathological Conference at The University of Texas Medical School at Houston on August 8, 1994. Circulation 1994; 90(5):2540-45. French translation published in Cardinale Revue de Cardiologie.

80) Smalling RW. Intra-aortic balloon counterpulsation with synchronized coronary

venous retroperfusion. The United States experience. (Editorial Comment) Cathet Cardiovasc Diagn 1994; 33:368-69.

81) Smalling RW. Transvalvular left ventricular assistance in acute myocardial

infarction with cardiogenic shock and high risk angioplasty: experimental and clinical results with the hemopump. J Interv Cardiol 1995 Jun; 8(3):265-73.

82) Hausmann D, Erbel R, Alibelli-Chemarin MJ, Boksch W, Caracciolo E, Cohn JM,

Culp SC, Daniel WG, De Scheerder I, DiMario C, Ferguson JJ, Fitzgerald PJ, Friedrich G, Ge J, Hanrath P, Hodgson JM, Isner JM, Jain S, Maier-Rudolph W, Mooney M, Moses J, Mudra H, Pinto FJ, Smalling RW, Talley D, Tobis JM, Walter PD, Weidinger F, Werner GS, Yeung AC, Yock PG. The safety of intracoronary

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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ultrasound: A multicenter survey of 2207 examinations. Circulation 1995; 91(3):623-30.

83) Hall R, Chen P, Varughese A, Smalling RW, Barasch E, Buja LM. A 69-year-old

woman with recurrent symptomatic pleural effusions. Circulation 1995; 91(3):882-96.

84) Feld S, Kjellgren O, Smalling RW. Aggressive interventional treatment of acute

myocardial infarction: lessons from the animal laboratory applied to the catheterization suite. Cardiology 1995; 86(5):365-73.

85) Smalling RW. Catheterization and cardiovascular diagnostics on safety of coronary

ultrasound angioplasty. Editorial Comment, article by Rosenschein, et al. Cathet Cardiovasc Diagn 1995 May; 35(1):72.

86) Smalling RW, Feld S, Ramanna N, Amirian J, Felli P, Vaughn WK, Swenson C,

Janoff A. Infarct salvage with liposomal prostaglandin E1 administered by intravenous bolus immediately before reperfusion in a canine infarction-reperfusion model. Circulation 1995 Aug 15; 92(4):935-43.

87) Smalling RW, Bode C, Kalbfleisch J, Sen S, Limbourg P, Forycki F, Habib G,

Feldman R, Hohnloser S, Seals A, The RAPID Investigators. More rapid, complete, and stable coronary thrombolysis with bolus administration of Reteplase (r-PA) compared with Alteplase (t-PA) infusion in acute myocardial infarction. Circulation 1995 Jun 1; 91(11):2725-32. French translation published in BLD Communication (Paris) September 1995.

88) Kjellgren O, Feld S, Loyd D, Schroth G, Anderson HV, Smalling RW. Successful

treatment of chronic total peripheral occlusions that failed conventional techniques using the stiff back end of the Glidewire

TM. Cathet Cardiovasc Diagn 1995 Dec;

36(4):360-63.

89) Feld S, Kjellgren O, Sweeney MS, Drtil A, Anderson HV, Schroth G, Tauss N, Taegtmeyer H, Smalling RW. Diffuse vasospasm following stenting of a free gastroepiploic artery graft: resolution with balloon angioplasty and intensive medical therapy. Cathet Cardiovasc Diagn 1995 Dec; 36(4):352-55.

90) Smalling RW. To regulate or be regulated, that is the question. (Editorial Comment)

J Interv Cardiol 1995; 8(2):113-14.

91) Feld S, Smalling RW. Letters to the Editor, J Am Coll Cardiol 1995; 26(2): 575-76.

92) Deckelbaum LI, Natarajan MK, Bittl JA, Rohlfs K, Scott J, Chisholm R, Bowman

KA, Strauss BH, Percutaneous Excimer Laser Coronary Angioplasty (PELCA) Investigators. Effect of intracoronary saline infusion on dissection during Excimer Laser Coronary Angioplasty: A randomized trial. J Am Coll Cardiol 1995 Nov 1; 26(5):1264-9.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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93) Bode C, Kohler B, Smalling RW, Runge MS. Reteplase (r-PA): A novel

recombinant plasminogen activator. Fibrinolysis 1995; (Suppl 1):97-99. 94) Anderson HV, Kirkeeide RL, Willerson JT, Smalling RW, Schroth G. Coronary

artery flow monitoring: the value of intravascular Doppler for detection of complications after interventions. Eur Heart J 1995 Nov; 16 (Suppl L):93-96.

95) Anderson HV, Kirkeeide RL, Willerson JT, Mishkel DC, Kjellgren O, Smalling RW,

Schroth G. Coronary artery flow monitoring following coronary interventions. Eur Heart J 1995 Oct; 16 (Suppl J):71-73.

96) Kjellgren O, Motarjeme A, Feld S, Mishkel DC, Underwood C, Kirkeeide RL,

Smalling RW. Rotational atherectomy with a new device: initial clinical experience. Cathet Cardiovasc Diagn 1996 Apr; 37(4):459-66.

97) White CJ, Ramee SR, Collins TJ, Escobar AE, Karsan A, Shaw D, Jain SP, Bass

TA, Heuser RR, Teirstein PS, Bonan R, Walter PD, Smalling RW. Coronary

thrombi increase PTCA risk: angioscopy as a clinical tool. Circulation 1996 Jan 15;

93(2):253-58. 98) Bode C, Runge MS, Smalling RW. The future of thrombolysis in the treatment of

acute myocardial infarction. Eur Heart J 1996; 17(Suppl E):55-60. 99) Feld S, Li G, Wu A, Felli P, Amirian J, Vaughn WK, Gornet T, Swenson C,

Smalling RW. Reduction of canine infarct size by bolus intravenous administration of liposomal prostaglandin E1 (TLC C-53): comparison with control, placebo liposomes, and continuous intravenous infusion of prostaglandin E1. Am Heart J 1996 Oct; 132(4):747-57.

100) Feld S, Ganim M, Carell ES, Kjellgren O, Kirkeeide RL, Vaughn WK, Kelly R,

McGhie AI, Kramer N, Loyd D, Anderson HV, Schroth G, Smalling RW. Comparison of angioscopy, intravascular ultrasound imaging and quantitative coronary angiography in predicting clinical outcome after coronary intervention in high-risk patients. J Am Coll Cardiol 1996 Jul; 28(1):97-105.

101) Bode C, Smalling RW, Berg G, Burnett C, Lorch G, Kalbfleisch JM, Chernoff R,

Christie LG, Feldman RL, Seals AA, Weaver WD, RAPID II Investigators. Randomized comparison of coronary thrombolysis achieved with double-bolus Reteplase (recombinant plasminogen activator) and front-loaded, accelerated Alteplase (recombinant tissue plasminogen activator) in patients with acute myocardial infarction. Circulation 1996 Sep 1; 94(5):891-98.

102) Smalling RW, Hanna GP. Clinical pharmacology and mechanism of action of

thrombolytic agents. Continuing Education Series. Thrombolytic therapy: New standard of care, Part 1, The science of Plasminogen Activators. Am J Cardiol 1996:9-15.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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103) Bode C, Nordt TK, Peter K, Smalling RW, Runge MS, Kubler W. Patency trials

with Reteplase (r-Pa): what do they tell us? Am J Cardiol 1996 Dec 19; 78(12A):16-19.

104) Bode C, Runge MS, Smalling RW. The future of thrombolysis in the treatment of

acute myocardial infarction. Eur Heart J 1996 Sep; 17 Suppl E:55-60. 105) Smalling RW. Molecular biology of plasminogen activators: what are the clinical

implications of drug design? Am J Cardiol 1996 Dec 19; 78(12A):2-7.

106) Smalling RW. Introduction. A symposium: Controversies in thrombolytic therapy. Am J Cardiol 1996; 78(12A):1.

107) Smalling RW. In the same vein - a step backwards (Editorial Comment) Cathet

Cardiovasc Diagn 1996; 38(2):171. 108) Hanna GP, Fujise K, Kjellgren O, Feld S, Fife C, Schroth G, Clanton T, Anderson

HV, Smalling RW. Infrapopliteal transcatheter interventions for limb salvage in diabetic patients: importance of aggressive interventional approach and role of transcutaneous oximetry. J Am Coll Cardiol 1997 Sep; 30(3):664-69.

109) Smalling RW. Pharmacological and clinical impact of the unique molecular

structure of a new plasminogen activator. Eur Heart J 1997; 18 Suppl F:F11-16.

110) Smalling RW. Experience with Reteplase in summary of findings. The First International Thrombolytic Collegium, Prognostic Markers for the Management of Acute Myocardial Infarction, May 1997:10-11.

111) Grover R, Smalling RW. Best strategy for reperfusion for acute myocardial

infarction: Direct PTCA. Fibrinolysis Proteol (Suppl 2) 1997; 11:71-74. 112) Smalling RW. Clinical trials to limit reperfusion injury. Fibrinolysis Proteol (Suppl

2) 1997; 11:123-24. 113) Ganim MS, Smalling RW. Coronary AVE micro stents: do we need another stent?

Editorial Comment. Cathet Cardiovasc Diagn 1997 Jun; 41(2):225. 114) GUSTO III Investigators. A comparison of Reteplase with Alteplase for acute myocardial infarction. N Engl J Med 1997 Oct 16; 337(16):1118-23. 115) Savage MP, Douglas JS, Fischman DL, Pepine CJ, King SB, Werner JA, Bailey SR,

Overlie PA, Fenton SH, Brinker JA, Leon MB, Goldberg S for the SAVED Trial Investigators. Stent placement with balloon angioplasty for obstructed coronary bypass grafts. N Engl J Med 1997; 337:740-47.

116) Bode C, Peter K, Nordt TK, Ruef J, Smalling RW, Kubler W. Pharmacology and

clinical efficacy of reteplase. Fibrinolysis Proteol (Suppl 2) 1997; 11:29-33.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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117) Bode C, Peter K, Moser M, Smalling RW, Weaver WD. Clinical trial results with a

new plasminogen activator. Eur Heart J 1997 Dec 18; Suppl F:F17-21.

118) Bode C, Kohler B, Moser M, Schmittner M, Smalling RW, Strasser RH. Reteplase

(r-PA): a new plasminogen activator. Expert Opin Investig Drugs 1997 Aug;

6(8):1099-1104.

119) Smalling RW. A fresh look at the molecular pharmacology of plasminogen

activators: From theory to test tube to clinical outcomes. Am J Health Syst Pharm

1997; 54 Suppl 1:S17-22.

120) Hanna G, Smalling RW. Reteplase, A new third generation thrombolytic agent.

Drugs Today 1997; 33(9):627-31.

121) Bode C, Moser M, Ruef J, Nordt T, Peter K, Kubler W, Smalling RW. Clinical

studies with Reteplase. Drugs Today 1997; 33(9):649-53.

122) Fujise K, Ganim M, Loyd D, Schroth G, Smalling RW. Bubble at tip of the stent

delivery system of the Palmaz-Schatz stent improves trackability to the target site. Cathet Cardiovasc Diagn 1998 Jan; 43(1):108-10.

123) Hanna GP, Smalling RW. Therapy with thrombolytic agents in coronary artery disease. Curr Opin Cardiol 1998 Jul; 13(4):267-73.

124) Scholz KH, Dubois-Rande JL, Urban P, Morice MC, Loisance D, Smalling RW,

Figulla HR. Clinical experience with the percutaneous hemopump during high-risk coronary angioplasty. Am J Cardiol 1998 Nov 1; 82(9):1107-10, A1106.

125) Smalling RW, Anderson HV. Pathophysiological insight into the possible optimal

therapies for acute myocardial infarction and unstable angina. Circulation 1998 Jan 13; 97(1):10-11.

126) Abu-Halawa SA, Thompson K, Kirkeeide RL, Vaughn WK, Rosales O, Fujise K,

Schroth G, Smalling RW, Anderson HV. Estrogen replacement therapy and

outcome of coronary balloon angioplasty in postmenopausal women. Am J Cardiol

1998; 82(4):409-13.

127) denHeijer P, Vermeer F, Ambrosioni E, Sadowski Z, Lopez-Sendon JL, vonEssen R,

Beaufils P, Thadani U, Adgey J, Pierard L, Brinker J, Davies RF, Smalling RW,

Wallentin L, Caspi A, Pangerl A, Trickett L, Huack C, Henry D, Chew P, InTime

Investigators. Evaluation of a weight-adjusted single-bolus plasminogen activator in

patients with myocardial infarction: a double-blind, randomized angiographic trial of

Lanoteplase versus Alteplase. Circulation 1998 Nov 17; 98(20):2117-25.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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128) Leon MB, Baim DS, Popma JJ, Gordon PC, Cutlip DE, Ho KKL, Gaimbartolomei

A, Diver D, Lasorda DM, Williams DO, Pocock SJ, Kuntz RE for the Stent

Anticoagulation Restenosis Study Investigators. A clinical trial comparing three

antithrombotic-drug regimens after coronary-artery stenting. N Engl J Med 1998;

339(23):1665-71.

129) Rihner MA, Smalling RW. Clinical challenges: Staged rotastenting of a total RCA

and critical LAD. Interventional Cardiology Bulletin 1999; 2(1): 3-4.

130) Zimmerman J, Fromm R, Meyer D, Boudreaux A, Wun CC, Smalling RW, Davis B,

Habib G, Roberts R. Diagnostic marker cooperative study for the diagnosis of

myocardial infarction. Circulation 1999; 99(13):1671-77.

131) Miller JM, Smalling RW, Ohman EM, Bode C, Betriu A, Kleiman NS, Schildcrout

JS, Bastos E, Topol EJ, Califf RM. Effectiveness of early coronary angioplasty and

abciximab for failed thrombolysis (reteplase or alteplase) during acute myocardial

infarction (results from the GUSTO-III trial). Global use of strategies to open

occluded coronary arteries. Am J Cardiol 1999 Oct 1; 84(7):779-84.

132) Feld S, Smalling RW. Gastroepiploic bypass graft stenting. Catheter Cardiovasc

Interv 1999 Jan; 46(1):118-19.

133) Hanna GP, Yhip P, Fujise K, Schroth GW, Rosales OR, Anderson HV, Smalling

RW. Intracoronary adenosine administered during rotational atherectomy of

complex lesions in native coronary arteries reduces the incidence of no-reflow

phenomenon. Catheter Cardiovasc Interv 1999 Nov; 48(3):275-78.

134) Peter J, Yhip A, Smalling RW. Primary stenting for acute myocardial infarction.

Thromb Haemost 1999 Sep; 82 Suppl 1:160-3.

135) Denktas AE, Smalling RW. Pasta without sauce? Editorial Comment. Catheter

Cardiovasc Interv 1999 Nov; 48(3):269-70.

136) Moser M, Nordt T, Peter K, Ruef J, Kohler B, Schmittner M, Smalling RW, Kubler

W, Bode C. Platelet function during and after thrombolytic therapy for acute

myocardial infarction with reteplase, alteplase, or streptokinase. Circulation 1999;

100(18):1858-64.

137) Cutlip DE, Leon MB, Ho KKL, Gordon PC, Giambartolomei A, Diver DJ, Lasorda

DM, Williams DO, Fitzpatrick MM, Desjardin A, Popma JJ, Kuntz RE, Baim DS.

Acute and nine-month clinical outcomes after “suboptimal” coronary stenting. J Am

Coll Cardiol 1999; 34(3):698-706.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

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138) Fitzgerald PJ, Oshima A, Hayase M, Metz JA, Bailey SR, Bain DS, Cleman MW,

Deutsch E, Diver DJ, Leon MB, Moses JW, Oesterle SN, Overlie PA, Pepine CJ,

Safian RD, Shani J, Simonton CA, Smalling RW, Teirstein PS, Zidar JP, Yeung AC,

Kuntz RE, Yock PG. Final results of the can routine ultrasound influence stent

expansion (CRUISE) study. Circulation 2000 August 1; 102(5):523-530.

139) Rosario RT, DiMaio DJ, Lapham RL, Sweeney M, Smalling RW, Barasch E.

Metastic ocular melanoma to the left ventricle inducing near-syncope attacks in an

84-year old woman. Chest 2000; 118(2):551-53.

140) Ohman EM, SPEED Investigators. Trial of Abciximab with and without low-dose

reteplase for acute myocardial infarction. Circulation June 20, 2000: 2788-2794.

141) Rihner M, Smalling RW. Cardiogenic shock. Curr Treat Options Cardiovasc Med

2000; 2(1):55-64.

142) Cafri C, De La Guardia B, Barasch E, Brink J, Smalling RW. Transseptal puncture

guided by intracardiac echocardiography during percutaneous transvenous mitral

commissurotomy in patients with distorted anatomy of the fossa ovalis. Catheter

Cardiovasc Interv 2000 Aug; 50(4):463-67.

143) Sdringola S, Assali A, Ghani M, Yepes A, Rosales O, Schroth GW, Fujise K,

Anderson HV, Smalling RW. Adenosine use during aortocoronary vein graft

interventions reverses but does not prevent the slow-no reflow phenomenon.

Catheter Cardiovasc Interv 2000 Dec; 51(4):394-99.

144) Ghani M, Yusuf W, Sdringola S, Smalling RW. Percutaneous coil embolization of

multiple arteriovenous malformations in left lung causing persistent hypoxia.

Circulation 2000; 102(18):E118.

145) Assali AR, Sdringola S, Rihner M, Smalling RW. Successful treatment of coronary

artery perforation in an Abciximab-treated patient by microcoil embolization.

Catheter Cardiovasc Interv 2000 Sept; 54(1):139-40.

146) Assali AR, Sdringola S, Ghani M, Moustapha A, Anderson HV, Schroth G, Fujise

K, Smalling RW, Rosales O. Causes of early reintervention after successful

coronary artery stenting. Am J Cardiol 2000 Nov 1; 86(9):1018-21, A1010.

147) Assali AR, Sdringola S, Ghani M, Denktas AE, Yepes A, Hanna GP, Schroth G,

Fujise K, Anderson HV, Smalling RW, Rosales OR. Intracoronary adenosine

administered during percutaneous intervention in acute myocardial infarction and

reduction in the incidence of “no reflow” phenomenon. Catheter Cardiovasc Interv

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

2000 Sep; 51(1):27-31; discussion 32.

148) Assali AR, Sdringola S, Ghani M, Westbrook LA, Anderson HV, Schroth G, Fujise

K, Smalling RW, Rosales OR. Timing of coronary stent thrombosis in patients

treated with prophylactic tirofiban. J Invasive Cardiol 2000 Sep; 12(9):460-63.

149) Fujise K, Yhip PA, Anderson HV, Schroth G, Rosales O, Smalling RW. Balloon to

artery ratio, not inflation pressure, correlates with adequate stent deployment: Size is

more important than pressure. J Interv Cardiol 2000; 13(4):223-29.

150) Sdringola S, Assali A, Anderson HV, Smalling RW. Restenosis: Relationship with

thrombosis. Curr Interv Cardiol Rep 2000 Nov; 2(4):285-92.

151) Assali AR, Moustapha A, Sdringola S, Rihner M, Smalling RW. Successful

treatment of coronary artery perforation in an abciximab-treated patient by microcoil

embolization. Catheter Cardiovasc Interv 2000 Dec; 51(4):487-89.

152) Moustapha A, Assali AR, Sdringola S, Vaughn WK, Fish RD, Rosales O, Schroth G,

Krajcer Z, Smalling RW, Anderson HV. Percutaneous and surgical interventions for

in-stent restenosis: Long term outcomes and effects of diabetes mellitus. J Am Coll

Cardiol 2001 Jun 1; 37(7):1877-82.

153) Assali AR, Sdringola S, Moustapha A, Ghani M, Achour H, Hale S, Schroth G,

Fujise K, Anderson HV, Smalling RW, Rosales OR. Percutaneous intervention in

saphenous venous grafts: In-stent restenosis lesions are safer than de novo lesions.

J Invasive Cardiol 2001 Jun; 13(6):446-50.

154) Smalling RW. Fibrinolytic monotherapy for acute myocardial infarction. J Invasive

Cardiol 2001 May 13; Suppl A:19A-20A.

155) Sdringola S, Assali AR, Ghani M, Moustapha A, Achour H, Yusuf SW, Fujise K,

Rosales O, Schroth GW, Anderson HV, Smalling RW. Risk assessment of slow or

no-reflow phenomenon in aortocoronary vein graft percutaneous intervention.

Catheter Cardiovasc Interv 2001 Nov; 54(3):318-24.

156) Assali AR, Salloum J, Sdringola S, Moustapha A, Ghani H, Hale S, Schroth G,

Fujise K, Anderson HV, Smalling RW, Rosales OR. Effects of clopidogrel

pretreatment before percutaneous coronary intervention in patients treated with

glycoprotein IIb/IIIa inhibitors (Abciximab or Tirofiban). Am J Cardiol 2001 Oct

15; 88(8):884-6, A886.

157) Assali AR, Sdringola S, Moustapha A, Rihner M, Denktas AE, Lefkowitz MA,

Campbell M, Smalling RW. Endovascular repair of traumatic pseudoaneurysm by

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

uncovered self-expandable stenting with or without transstent coiling of the

aneurysm cavity. Catheter Cardiovasc Interv 2001 Jun; 53(2):253-58.

158) Fromm R, Meyer D, Zimmerman J, Boudreaux A, Wun CC, Smalling RW, Davis B,

Habib G, Roberts R. A double-blind, multicentered study comparing the accuracy of

diagnostic markers to predict short- and long-term clinical events and their utility in

patients presenting with chest pain. Clin Cardiol 2001; 24(7):516-20.

159) Boccalandro F, De La Guardia B, Smalling RW. Rotational aortogram with three-

dimensional reconstruction in a case of repaired aortic coarctation. Circulation 2001

Jul 31; 104(5):620-21.

160) Assali AR, Sdringola S, Smalling RW, Sapp S, Anderson HV. Adverse events

occurring after coronary stenting are rare after 12 hours independently of GP IIb/IIIa

inhibition. Insight from the EPISTENT trial. Proceedings: American Heart

Association, 2001.

161) Mooney M, Talley D, Silver S, Teirstein P, Rodriguez R, Sanborn T, Feldman T,

Leon M, Collins T, Wilentz J, Saucedo J, Leimgruber P, Prichard A, Cohen D,

Ramee S, Heuser, Smalling RW, Kuntz R, Gershony G. Assessment of the safety

and efficacy of the DUETT vascular hemostasis device – Final results of the SEAL

trial. Am Heart J 2002 Apr; 143(4):612-9.

162) Moustapha A, Assali AR, Sdringola S, Yusuf SW, Vaughn WK, Fish RD, Schroth

GW, Krajcer Z, Rosales OR, Smalling RW, Anderson HV. Abciximab

administration and clinical outcomes after percutaneous intervention for in-stent

restenosis. Catheter Cardiovasc Interv 2002 Jun; 56(2):184-87.

163) Boccalandro F, Awadalla H, Smalling RW. Percutaneous transcatheter coil

embolization of two coronary fistulas originating from the left main ostium and left

anterior descending artery. Catheter Cardiovasc Interv 2002 Oct; 57(2):221-23.

164) Moustapha A, Salloum J, Saikia S, Awadalla H, Ghani M, Sdringola S, Schroth G,

Assali AR, Smalling RW, Anderson HV, Rosales O. Combined cutting balloon

angioplasty and intracoronary beta radiation for treatment of in-stent restenosis:

Clinical outcomes and effect of pullback radiation for long lesions. Catheter

Cardiovasc Interv 2002 Nov; 57(3):325-29.

165) Assali AR, Sdringola S, Moustapha A, Ghani M, Salloum J, Schroth G, Fujise K,

Anderson HV, Smalling RW, Rosales OR. Outcome of access site in patients treated

with platelet glycoprotein IIb/IIIa inhibitors in the era of closure devices. Catheter

Cardiovasc Interv 2003 Jan; 58(1):1-5.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

166) Boccalandro F, Amhad M, Smalling RW, Sdringola S. Oral acetylcysteine does not

protect renal function from moderate to high doses of intravenous radiographic

contrast. Catheter Cardiovasc Interv 2003 Mar; 58(3):336-41.

167) Baptista EG, Achour H, Boccalandro F, Smalling RW. Cavernous hemangioma of

the foot and antecubital fossa: An alternative therapeutic option. Catheter

Cardiovasc Interv 2003 Apr; 58(4):527-31.

168) Smalling RW, Giesler G. The level I cardiovascular center: Is it time? Am Heart

Hosp J 2003 Spring; 1(2):170-74.

169) Assali AR, Moustapha A, Sdringola S, Salloum J, Awadalla H, Saikia S, Ghani M,

Hale S, Schroth G, Rosales O, Anderson HV, Smalling RW. The dilemma of

success: Percutaneous coronary interventions in patients ≥ 75 years of age –

successful but associated with higher vascular complications and cardiac mortality.

Catheter Cardiovasc Interv 2003 Jun; 59(2):195-99.

170) Awadalla H, Salloum J, Moustapha A, Assali A, Sdringola S, Fujise K, Anderson

HV, Rosales O, Schroth G, Smalling RW. Rheolytic thrombectomy does not

prevent slow-, no-reflow during percutaneous coronary intervention in acute

myocardial infarction. Int J Angiol 2003; 12(3):183-87.

171) Boccalandro F, Giesler G, Amhad M, Smalling RW. Images in cardiovascular

medicine. Rotational aortogram with three-dimensional reconstruction in a case of

celiac artery stenosis. Circulation 2003 Oct 28; 108(17):2153.

172) Hong TE, Thaler D, Brorson J, Heitschmidt M, Hijazi ZM. Transcatheter closure of

patent foramen ovale associated with paradoxical embolism using the amplatzer PFO

occluder: Initial and intermediate-term results of the US multicenter clinical trial.

Catheter Cardiovasc Interv 2003; 60(4):524-28.

173) Awadalla HM, Salloum JG, Smalling RW. Renal artery compromise treated

percutaneously in a patient with chronic aortic dissection: A case report. Catheter

Cardiovasc Interv 2004 Apr; 61(4):445-49.

174) Boccalandro F, Baptista E, Muench A, Carter C, Smalling RW. Comparison of

intracardiac echocardiography versus transesophageal echocardiography guidance

for percutaneous transcatheter closure of atrial septal defect. Am J Cardiol 2004 Feb

15; 93(4):437-40.

175) Boccalandro F, Muench A, Salloum J, Awadalla H, Carter C, Barasch E, Smalling

RW. Inter-atrial defect sizing by intracardiac and transesophageal echocardiography

compared with fluoroscopic measurements in patients undergoing percutaneous

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

transcatheter closure. Catheter Cardiovasc Interv 2004 Jul; 62(3):415-20.

176) Smalling RW, Foote M, Molineux G, Swanson SJ, Elliott S. Drug-induced and

antibody-mediated pure red cell aplasia: A review of literature and current

knowledge. Biotechnol Annu Rev 2004; 10:237-50.

177) Stone GW, Ellis SG, Cox DA, Hermiller J, O’Shaughnessy C, Mann JT, Turco M,

Caputo R, Bergin P, Greenberg J, Popma JJ, Russell ME, for the TAXUS-IV

Investigators. A polymer-based, Paclitaxel-eluting stent in patients with coronary

artery disease. N Engl J Med 2004; 350(3);221-30.

178) Awadalla H, Salloum JG, Smalling RW, Sdringola S. Catheter-induced dissection

of the left main coronary artery with and without extension to the aortic root: A

report of two cases and a review of the literature. J Interv Cardiol 2004 Aug;

17(4):253-57.

179) Awadalla H, Boccalandro F, Majano RA, Moustapha A, Salloum JG, Smalling RW.

Percutaneous closure of patent foramen ovale guided by intracardiac

echocardiography and performed through the transfemoral approach in the presence

of previously placed inferior vena cava filters: A case series. Catheter Cardiovasc

Interv 2004 Oct; 63(2):242-46.

180) Smalling RW, Giesler GM. Early and aggressive treatment of patients with acute ST

segment elevation and non-ST segment elevation myocardial infarction leads to

improved clinical outcomes. Crit Pathw Cardiol 2004 Sep; 3(3):121-27

181) Bettmann MA, Dake MD, Hopkins LN, Katzen BT, White CJ, Eisenhaur AC, Pearce

WH, Rosenfield KA, Smalling RW, Sos TA, Venbrux AC. Atherosclerotic Vascular

Disease Conference: Writing Group VI: Revascularization. Proceedings: AHA

Conference. Circulation 2004 Jun 1; 109(21):2643-50.

182) Hobson R, Howard V, Roubin G, Brott T, Ferguson R, Popma J, Graham D, Howard

G. Carotid artery stenting is associated with increased complications in

octogenarians: 30-day stroke and death rates in the CREST lead-in phase. J Vasc

Surg 2004; 40(6):1106-11.

183) Boccalandro F, Assali A, Fujise K, Smalling RW, Sdringola S. Vascular access site

complications with the use of closure devices in patients treated with platelet

glycoprotein IIb/IIIa inhibitors during rescue angioplasty. Catheter Cardiovasc

Interv 2004 Nov; 63(3):284-89.

184) Achour H, Boccalandro F, Felli P, Amirian J, Uthman M, Buja M, Smalling RW.

Mechanical left ventricular unloading prior to reperfusion reduces infarct size in a

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

canine infarction model. Catheter Cardiovasc Interv 2005 Feb; 64(2):182-92.

185) Boccalandro F, Cohen A, Raval B, Chen P, Muench A, Achour H, Carter C,

Underwood C, Smalling RW. Superiority of endovascular grafts compared to bare

metal stents with transstent coil embolization for endovascular abdominal aortic

aneurysm repair in patients at high risk for surgery. Catheter Cardiovasc Interv

2005 Mar; 64(3):283-90.

186) Muench A, Boccalandro F, Ellis K, Smalling RW. Approaches to correct device

malposition in percutaneous PFO closure: Anatomical and technical implications.

Catheter Cardiovasc Interv 2005 Mar; 64(3):338-44.

187) Ellis K, Murtagh B, Loghin C, Muench A, Boccalandro F, Go B, Ahmad M,

Burjonroppa S, Rosales O, Smalling RW. The use of brachytherapy to treat renal

artery in-stent restenosis. J Interv Cardiol 2005 Feb; 18(1):49-54.

188) Awadalla H, Sabet S, El Sebaie A, Rosales O, Smalling RW. Catheter-induced left

main dissection incidence, predisposition and therapeutic strategies experience from

two sides of the hemisphere. J Invasive Cardiol 2005 Apr; 17(4):233-6.

189) Ellis K, Boccalandro F, Burjonroppa S, Muench A, Giesler GM, Smalling RW,

Sdringola S. Risk of bleeding complications is not increased in patients undergoing

rescue versus primary percutaneous coronary intervention for acute myocardial

infarction. J Interv Cardiol 2005 Oct; 18(5):361-65.

190) Murtagh BM, Lenihan DJ, Smalling RW. Endovascular repair of abdominal

aneurysms: Is this the method of choice? Am J Med Sci 2005 Oct; 330(4):184-91.

191) Sethuraman S, Aglyamov S, Amirian J, Smalling R, Emelianov S. Intravascular

photoacoustic imaging to detect and differentiate atherosclerotic plaques.

Proceedings of the 2005 IEEE International Ultrasonics Symposium 2005; 1:133-36.

192) Ganim RP, Muench A, Giesler GM, Smalling RW. Difficult retrieval of the EPI

Filterwire with a 5 French FR4 coronary catheter following carotid stenting.

Catheter Cardiovasc Interv 2006 Feb; 67(2):309-11.

193) Murtagh B, Smalling RW. Cardioembolic stroke. Curr Atheroscler Rep 2006 Jul;

8(4):310-16.

194) Giesler GM, Gomez JS, Letsou G, Vooletich M, Smalling RW. Initial report of

percutaneous right ventricular assist for right ventricular shock secondary to right

ventricular infarction. Catheter Cardiovasc Interv 2006 Aug; 68(2):263-66.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

195) White C, Iyer S, Hopkins N, Katzen B, Russell M. Carotid stenting with distal

protection in high surgical risk patients: The BEACH trial 30 day results. Catheter

Cardiovasc Interv 2006 April; 67(4):503-12.

196) Assali AR, Moustapha A, Sdringola S, Denktas AE, Willerson JT, Holmes DR,

Smalling RW. Acute coronary syndrome may occur with in-stent restenosis and is

associated with adverse outcomes (The PRESTO trial). Am J Cardiol 2006 Sep 15;

98(6):729-33.

197) Smalling RW. Role of fibrinolytic therapy in the current era of ST-segment

elevation myocardial infarction management. Am Heart J 2006 Jun; 151(6

Suppl):S17-23.

198) Ali A, Iliescu CA, Smalling RW. Brugada syndrome in a black man with seizures

and urinary incontinence. Tex Heart Inst J 2006; 33(2):273-4.

199) Sethuraman S, Aglyamov SR, Amirian JH, Smalling RW, Emelianov SY.

Development of a combined intravascular ultrasound and photoacoustic imaging

system. Proceedings of the 2006 SPIE Photonics West Symposium: Photons Plus

Ultrasound Imaging and Sensing; 6086:108-17.

200) Chen CI, Iguchi Y, Garami Z, Malkoff MD, Smalling RW, Campbell MS,

Alexandrov AV. Analysis of emboli during carotid stenting with distal protection

device. Cerebrovasc Dis 2006; 21(4):223-8.

201) Carroll J, Onorato E, Saver J, Smalling R, Thaler D, Tobis J. Data that may shed

some light on: “Arguments against insisting on randomized trials for PFO closure.”

Catheter Cardiovasc Interv 2007; 70(6):904-05; author reply 906.

202) The TRIUMPH Investigators. Effect of Tilarginine Acetate in patients with acute

myocardial infarction and cardiogenic shock: The TRIUMPH randomized controlled

trial. JAMA 2007; 297(15): 1657-66.

203) Thiele H, Smalling RW, Schuler GC. Percutaneous left ventricular assist devices in

acute myocardial infarction complicated by cardiogenic shock: Eur Heart J 2007

Sep; 28(17):2057-63.

204) Anderson HV, Smalling RW, Henry TD. Drug-eluting stents for acute myocardial

infarction. J Am Coll Cardiol 2007 May 15; 49(19):1931-33.

205) Sethuraman S, Aglyamov SR, Amirian JH, Smalling RW, Emelianov SY.

Intravascular photoacoustic imaging using an IVUS imaging catheter. IEEE Trans

Ultrason Ferrelectr Freq Control 2007 May; 54(5): 978-86.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

206) Sethuraman S, Amirian JH, Litovsky SH, Smalling RW, Emelianov SY. Ex vivo

characterization of atherosclerosis using intravascular photoacoustic imaging. Opt

Express 2007 Dec 10; 15(25):16657-66.

207) Peacock WF, Hollander JE, Smalling RW, Bresler MJ. Reperfusion strategies in the

emergency treatment of ST-elevation myocardial infarction (STEMI). Review. Am J

Emerg Med 2007 Mar; 25(3):353-66.

208) Sanz M, Smalling RW, Brewer DL, French WJ, Smaha LA, Ting HH, Casey DE.

Development of systems of care for ST-elevation myocardial infarction patients:

The physician perspective. Circulation 2007 Jul 10; 116(2):e39-42.

209) Smalling RW, Giesler GM, Julapalli VR, Denktas AE, Sdringola SM, Vooletich

MT, McCarthy JJ, Bradley RN, Persse DE, Richter BK, Yagi M, Fujise K,

Anderson HV. Pre-hospital reduced-dose fibrinolysis coupled with urgent PCI

reduces time to reperfusion and improves angiographic perfusion score compared

with pre-hospital fibrinolysis alone or primary PCI: Results of the PATCAR* Pilot

Trial *(Pre-Hospital Administration of Thrombolytic Therapy with Urgent Culprit

Artery Revascularization). J Am Coll Cardiol 2007 Oct 16; 50(16):1612-14.

210) Sethuraman S, Amirian JH, Litovsky SH, Smalling RW, Emelianov SY.

Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic

plaques. Opt Express 2008 Mar 3; 16(5):3362-67.

211) Sethuraman S, Aglyamov SR, Smalling RW, Emelianov SY. Remote temperature

estimation in intravascular photoacoustic imaging. Ultrasound Med Biol 2008 Feb;

34(2):299-308.

212) Persse DE, McCarthy JJ, Vooletich M, Richter BK, Anderson HV, Denktas AE,

Sdringola SM, Smalling RW. Pre-hospital fibrinolysis in concert with rapid PCI.

Clinical trial shows promising results for use of clot-dissolving agents in the field.

JEMS 2008; 33(3):78-88.

213) Emilianov S, Wang B, Su J, Karpiouk A, Yantsen E, Sokolov K, Amirian J,

Smalling R, Sethuraman S. Intravascular ultrasound and photoacoustic imaging.

Proceedings: 30th

Annual International IEEE-EMBS Conference, Vancouver, BC,

Canada, August 20-24, 2008. Conf Proc IEEE Eng Med Biol Soc 2008; 2008:2-5.

214) LeDoux JF, Tamareille S, Felli PR, Amirian J, Smalling RW. Left ventricular

unloading with intra-aortic counter pulsation prior to reperfusion reduces myocardial

release of endolethin-1 and decreases infarction size in a porcine ischemia-

reperfusion model. Catheter Cardiovasc Interv 2008 Oct 1; 72(4):513-21.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

215) Denktas AE, Athar H, Henry TD, Larson DM, Simons M, Chan RS, Niles NW,

Thiele H, Schuler G, Ahn C, Sdringola S, Anderson HV, McKay RG, Smalling RW.

Reduced-dose fibrinolytic acceleration of ST-segment elevation myocardial

infarction treatment coupled with urgent percutaneous coronary intervention

compared to primary percutaneous coronary intervention alone. Results of the

AMICO (Alliance for Myocardial Infarction Care Optimization) Registry. JACC

Cardiovasc Interv 2008 Oct; 1(5): 504-10.

216) Tamareille S, Achour H, Amirian J, Felli P, Bick RJ, Poindexter B, Geng YJ, Barry

WH, Smalling RW. Left ventricular unloading before reperfusion reduces

endothelin-1 release and calcium overload in porcine myocardial infarction. J

Thorac Cardiovasc Surg 2008; 136(2):343-51.

217) Anderson HV, Denktas AE, Smalling RW, Sdringola S, Vooletich MT. Reperfusion

strategies in ST-elevation myocardial infarction. Am J Cardiol 2009 Jan 15;

103(2):284-86.

218) Wang B, Su J, Amirian J, Litovsky SH, Smalling R, Emelianov S. On the possibility

to detect lipid in atherosclerotic plaques using intravascular photoacoustic imaging.

Proceedings: 31st Annual International Conference of the IEEE EMBS, Minneapolis,

MN, USA, September 2-6, 2009. Conf Proc IEEE Eng Med Biol Soc 2009;

2009:4767-70.

219) Feldman T, Kar S, Rinaldi M, Fail P, Hermiller J, Smalling R, Whitlow PL, Gray W,

Low R, Herrmann HC, Lim S, Foster E, Glower D. Percutaneous mitral repair with

the MitraClip system: Safety and midterm durability in the initial EVEREST

(Endovascular Valve Edge-to-Edge REpair Study) cohort. J Am Coll Cardiol 2009

Aug 18; 54(8):686-94.

220) Smalling RW. Ischemic time: The new gold standard for ST-segment elevation

myocardial infarction care. J Am Coll Cardiol 2009 Dec 1; 54(23):2154-56.

221) Barker CM, Gomez J, Grotta JC, Smalling RW. Feasibility of carotid artery stenting

in patients with angiographic string sign. Catheter Cardiovasc Interv 2010 June 1;

75(7):1104-09.

222) Wang B, Su JL, Amirian J, Litovsky SH, Smalling R, Emilianov S. Detection of

lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular

photoacoustic imaging. Opt Express 2010 Mar 1; 18(5):4889-97.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

223) Wang B, Su JL, Karpiouk AB, Sokolov KV, Smalling RW, Emelianov SY.

Intravascular photoacoustic imaging. IEEE Journal of Selected Topics in Quantum

Electronics 2010 May/June; 16(3):588-99.

224) Lim DS, Kunjummen BJ, Smalling R. Mitral valve repair with the mitraclip device

after prior surgical mitral annuloplasty. Catheter Cardiovasc Interv 2010 Sept 1;

76(3):455-459.

225) Letsou GV, Pate TD, Gohean JR, Kurusz M, Longoria RG, Kaiser L, Smalling RW.

Improved left ventricular unloading and circulatory support with synchronized

pulsatile left ventricular assistance compared to continuous flow left ventricular

assistance in an acute porcine LV failure model. J Thorac Cardiovasc Surg 2010;

140(5):1181-88.

226) Feldman T, Foster E, Glower DG, Kar S, Rinaldi MJ, Fail PS, Smalling RW, Siegel

R, Rose GA, Engeron E, Loghin C, Trento A, Skipper ER, Fudge T, Letsou GV,

Massaro JM, Mauri L, EVEREST II Investigators. Percutaneous repair or surgery

for mitral regurgitation. New Engl J Med 2011 Apr 14; 364(15):1395–1406.

227) Patel MR, Smalling RW, Thiele H, Barnhart HX, Zhou Y, Chandra P, Chew D,

Cohen M, French J, Perera D, Ohman EM. Intra-aortic balloon counterpulsation and

infarct size in patients with acute anterior myocardial infarction without shock: The

CRISP-AMI randomized trial. JAMA 2011 Apr 14; 306(12): E1–E9.

228) Siegel RJ, Biner S, Rafique AM, Rinaldi M, Lim S, Fail P, Hermiller J, Smalling R,

Whitlow PL, Herrmann HC, Foster E, Feldman T, Glower D, Kar S, EVEREST

Investigators. The acute hemodynamic effects of mitraclip therapy. J Am Coll

Cardiol 2011 April 19; 57(16): 1658-65.

229) Denktas A, Anderson HV, McCarthy J, Smalling RW. Total ischemic time: The

correct focus of attention for optimal ST-segment elevation myocardial infarction

care. JACC Cardiovascular Interventions 2011 June; 4(6): 599-604.

230) Huynh T, Birkhead J, Huber K, O’Loughlin J, Stenestrand U, Weston C, Jernberg T,

Schull M, Welsh RC, Denktas AE, Travers A, Sookram S, Theroux P, Tu JV,

Timmis A, Smalling R, Danchin N. The pre-hospital fibrinolysis experience in

Europe and North America and implications for wider dissemination. JACC

Cardiovascular Interventions 2011 August 1; 4(8): 877-83.

231) Graf IM, Miri R, Smalling RW, Emelianov S. Clinical benefits of integrating

cardiac and vascular models. Expert Opin Med Diagn 2011 Nov; 5(6):501-15.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

232) Whitlow PL, Feldman T, Pedersen WR, Lim S, Kipperman R, Smalling R, Bajwa T,

Hermann HC, Lasala J, Maddux JT, Tuzcu M, Kapadia S, Trento A, Siegel RJ,

Foster E, Glower D, Mauri L, Kar S, EVEREST II Investigators. Acute and 12-

month results with catheter-based mitral valve leaflet repair: The EVEREST II

(Endovascular Valve Edge-to-Edge Repair) High Risk Study. J Am Coll Cardiol

2012 Jan 10; 59(2): 130-9.

233) Wang B, Karpiouk A, Yeager D, Amirian J, Litovsky S, Smalling R, Emelianov S.

Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the

presence of luminal blood. Optics Letters 2012 Apr 1; 37(7): 1244-6.

234) Karpiouk AB, Wang B, Amirian J, Smalling RW, Emelianov SY. Feasibility of in

vivo intravascular photoacoustic imaging using integrated ultrasound and

photoacoustic imaging catheter. J. Biomed. Opt. 2012 Sept; 17(9): 096008-1 – 6.

235) Yeager D, Karpiouk A, Wang B, Amirian J, Sokolov K, Smalling R, Emilianov S.

Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque

through luminal blood. J. Biomed. Opt. 2012 Oct; 17(10): 106016-1 – 8.

236) Gohean JR, George MJ, Pate TD, Kurusz M, Longoria RG, Smalling RW.

Verification of a computational cardiovascular system model comparing the

hemodynamics of a continuous flow to a synchronous valveless pulsatile flow left

ventricular assist device. ASAIO Journal 2013; 59: 107-16.

237) Carroll JD, Saver JL, Thaler DE, Smalling RW, Berry S, MacDonald LA, Marks DS,

Tirschwell DL, RESPECT Investigators. Closure of patent foramen ovale versus

medical therapy after cryptogenic stroke. New Engl J Med 2013 Mar 21; 368(12):

1092-100.

238) Bhatt NS, Solhpour A, Balan P, Barekatain A, McCarthy JJ, Sdringola S, Denktas

AE, Smalling RW, Anderson HV. Comparison of in-hospital outcomes with low-

dose fibrinolytic therapy followed by urgent percutaneous coronary intervention

versus percutaneous coronary intervention alone for treatment of ST-elevation

myocardial infarction. Am J Cardiol 2013; 111:1576-9.

239) Tamareille S, Terwelp M, Amirian J, Felli P, Zhang XQ, Barry WH, Smalling RW.

Endothelin-1 release during the early phase of reperfusion is a mediator of

myocardial reperfusion injury. Cardiology 2013; 125:242-249.

240) Solhpour A, Chang K, Balan P, Cai C, Sdringola S, Denktas AE, Smalling RW,

Anderson HV. Comparison of outcomes for patients ≥75 years of age treated with

pre-hospital reduced-dose fibrinolysis followed by percutaneous coronary

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

intervention versus percutaneous coronary intervention alone for treatment of ST-

elevation myocardial infarction. Am J Cardiol 2014 Jan 1; 113(1): 60-3.

PUBLICATIONS (Chapters): 1) Smalling RW, Fuentes F, Matthews MW, Freund G, Gould KL. Influence of success

in intracoronary thrombolysis on mortality in acute myocardial infarction. Progress in Fibrinolysis VI, CH 112:501, 1983.

2) Smalling RW. Cardiac catheterization: In: Weeks L, editor. Advanced Cardiovascular Nursing. Boston: Blackwell Scientific Publications, Inc.; 1985.

3) Smalling RW, Gould KL. Intracoronary streptokinase in acute myocardial

infarction: In: Connor WE, Bristow JD, editors. Coronary Heart Disease: Prevention, Complications, and Treatment. Philadelphia: J. B. Lippincott Co.; 1985, p.317-332.

4) Gould KL, Smalling RW, Mullani N, Goldstein RA, Fuentes F, Wong G, Matthews

MW. Opposite ends of the intervention spectrum: Effects of intracoronary thrombolysis on long-term survival and LF function - Detection of early CAD by non-invasive positron imaging: In: Meyer J, Erbel R, Rupprecht HJ, editor. Improvement of Myocardial Perfusion: Thrombolysis, Angioplasty, Bypass Surgery. Boston: Martinus Nihjoff Publishers; 1985.

5) Fuentes F, Smalling RW, Hicks CH, Matthews MW, Gould KL. Thrombolytic

therapy in myocardial infarction of the elderly patient: In: Coodley EL, editor. Geriatric Heart Disease. Lakeland: PSG Publishing Company, Inc.; 1985, p. 404-410.

6) Smalling RW, Ekas R, Tiberi M, Felli P, Ochs R. Synchronized coronary sinus

retroperfusion during acute regional ischemia: In: Mohl W, Faxon D, Wolner E, editors. Clinics of CSI. New York: Steinkopff Verlag Darmstadt; 1986, p. 271-275.

7) Cassidy DB, Smalling RW. Acute MI: Role of thrombolysis and intervention: In:

Ewer M, editor. Critical Care Clinic of North America. Philadelphia: W.B. Saunders Company; l989.

8) Smalling RW. Left ventricular assist devices available to the cardiologist:

Indications, techniques, early and late results. Percutaneous left ventricular assist: In: Vogel JHK, King III SB, editors. The Practice of Interventional Cardiology. 2

nd

ed. St. Louis: Mosby Year Book Inc.; 1992. 9) Smalling RW. Percutaneous left ventricular assist: In: Topol EJ, editor.

Interventional Cardiology. 2nd

ed. Philadelphia: W. B. Saunders Company; 1993. 10) Anderson HV, Smalling RW, Serruys P. Medical treatment - Use of angioplasty,

atherectomy, and laser. Coronary artery disease: In: Willerson JT, Cohn JN, editors. Cardiovascular Medicine. Orlando: Churchill Livingstone, Inc.; 1994.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

11) Smalling RW. Coronary angiography: Methods and quantification (Chapter 9): In: Peterson LK, Nicod P, editors. Cardiac Catheterization: Methods, Diagnosis, and Therapy. Philadelphia: W. B Saunders Company; 1997, p.159-179.

12) Hanna GP, Smalling RW. Angina pectoris: In: Rakel RE, editor. Conn’s Current

Therapy. 1997 ed. Philadelphia: W. B. Saunders Company; 1997. 13) Feld S., Smalling RW. Intravascular angioscopy in the analysis of stenosis

morphology and composition: Therapeutic implications: In: Klein LW, editor. Coronary Stenoses Morphology: Analysis and Implication. Norwell: Kluwer Academic Publishers; 1997.

14) Bode C, Nordt TK, Kohler B, Weaver WD, Smalling RW. Novel tissue plasminogen

activators: Reteplase (r-PA) (Chapter 19): In: Becker R, editor. Textbook of Coronary Thrombosis and Thrombolysis. Norwell: Kluwer Academic Publishers; 1997, p. 263-68.

15) Hanna GP, Smalling RW. New thrombolytics, adjunctive therapies, and mechanical

interventions for acute ischemic syndromes: A current perspective: In: Timmis GC, editor. Thrombolytic Therapies. Armonk: Futura Publishing Company, Inc.; 1999.

16) Smalling RW, Denktas A. Percutaneous coronary intervention for acute myocardial

infarction (Chap 39): In: Willerson JT, Cohn JN, editors. Cardiovascular Medicine. 2

nd ed. New York: Harcourt Brace & Company, 2000.

17) Salloum J, Smalling RW. Mechanical circulatory assist devices (Chapter 13): In:

Hollenberg SM, Bates ER, editors. Cardiogenic Shock. Armonk: Futura Publishing Company, Inc.; 2002, p. 235-280.

18) Moustapha A, Anderson HV, Smalling RW. Conservative vs invasive strategies in

acute coronary syndrome. Contemporary Cardiology. Submitted to Cannon CP. 19) Boccalandro F, Smalling RW. Traumatic heart disease, Exercise and the heart,

Exercise stress testing: In: Adair OV, editor. Cardiology Secrets. 2nd

ed. Philadephia: Hanley & Belfus; 2001, p. 171-74, p. 325-27, p. 51-54.

20) Reddy V, Achour H, Sdringola S, Milner T, Casscells W, Smalling RW. La placca

vulnerabile nel contesto clinico: Un problema locale o sistemico? La nostra esperienza: In: Klugmann S, editor. Cardiologia 2003. Milano: Associazone Amici del Centro di Cardiologia e Cardiochirurgia “Angelo de Gasperis,” 2003, p.110-119.

21) Boccalandro F, Smalling RW. Critical limb ischemia and limb salvage: In: Joiner

JT, Guzman R, editors. Wound Care Practice. Flagstaff: Best Publishing Company; 2004.

22) Smalling RW, Geisler GM. The role of percutaneous coronary revascularization in

advanced ischemic heart disease: Modern angioplasty and stent technology; technique, application and efficacy, comparison to surgical: In: Delgado R, Arora

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

HS, editors. Interventional Treatment of Advanced Ischemic Heart Disease. New York: Springer-Verlag London Limited, 2009, p. 69-84.

23) Sethuraman S, Wang B, Smalling R, Emelianov S. Intravascular photoacoustic

imaging of atherosclerosis (Chapter 36): In: Wang LV, editor. Photoacoustic Imaging and Spectroscopy. Boca Raton: CRC Press Taylor and Francis Group; 2009, p. 451-461.

24) Ellis W, Weirick T, Smalling RW. Intra-aortic balloon pump counterpulsation,

percutaneous left ventricular support (Chapter 39): In: Mukherjee D, Bates E, Roffi M, Moliterno D, editors. Cardiovascular Catheterization and Intervention: A Textbook of Coronary, Peripheral & Structural Heart Disease. Taylor and Francis Group; 2010.

25) Daraban N, Reyes M, Smalling RW. Transcatheter occlusion of atrial septal defects for prevention of recurrence of paradoxical embolism (Chapter 11): In: Syamasundar Rao P, editor. Atrial Septal Defect. InTech; 2012.

PUBLICATIONS (Books):

1) Smalling RW: Characteristics of the Viscoelasticity of Human Blood. Masters Thesis, The University of Texas at Austin, 1972.

2) Smalling RW: Digital boundary detection, volumetric and wall motion analysis of

left ventricular cine angiograms. Ph.D. Dissertation, The University of Texas Graduate School of Biomedical Sciences, 1977.

PUBLICATIONS (World Wide Web ):

1) Richard W. Smalling, M.D., Ph.D., Evolution Of Treatment For Acute Myocardial Infarction: What's In Store For 1997 And Beyond?, 1996, Cyberounds.com, October.

2) Richard W. Smalling, M.D., Ph.D., Surgical Mitral Commissurotomy: When Are

Less Invasive Treatments Indicated?, 1996, Cyberounds.com, November.

3) Roger Grover, M.D. and Richard W. Smalling, M.D., Ph.D., Should ACE Inhibitors Be Used in All Patients After Myocardial Infarction? 1997, Cyberounds.com, January.

4) Richard W Smalling, MD PhD, and Ali Denktas, MD: An Aggressive Approach to

the Treatment of Acute Myocardial Infarction: Lessons from Recent Clinical Trials. 1999, Cyberounds.com, July.

5) Frank A Laws, MD, and Richard W Smalling, MD PhD: The Role of Angiotensin

Receptor Blockade in the Treatment of Heart Failure. 2000, Cyberounds.com, January.

CURRICULUM VITAE - RICHARD W. SMALLING, M.D., PhD.

Revised May 2014

6) Joseph Salloum, MD, and Richard W Smalling, MD PhD: Management of the No-Reflow Phenomenon. International Congress of Cardiology on Internet, Federacion Argentina De Cardiologia 2

nd Virtual Congress of Cardiology, 2001.

7) Joseph G. Salloum, MD, Morgan Campbell, MD, and Richard W Smalling MD PhD:

Which Patients Should be Considered for Carotid Artery Stenting? 2001, Cyberounds.com, September.

8) Frank A Laws, MD and Richard W Smalling MD PhD: Optimal Treatment for

Hypertension in patients at Risk for Cardiovascular Disease: A New Perspective. 2001, Cyberounds.com, December.

9) Hany Awadalla, MD, Abid R Assali, MD, and Richard W Smalling MD PhD:

Abdominal Aortic Aneurysm Repair Using An Endovascular Technique. 2002, Cyberounds.com, August.

10) Richard W Smalling MD PhD: CardioGolf. Cyberounds.com 2001.

11) Ali H. Shakir, MD, Richard M. Smalling, MD PhD, Rebecca R. Hung, MD: The

Role of B-Type Natriuretic Peptide in the Diagnosis and Management of Heart Failure. 2003, Cyberounds.com, December.