CURRICULUM VITAE Randolph H. Stewart, DVM, Ph.D. · CURRICULUM VITAE. Randolph H. Stewart, DVM,...

CURRICULUM VITAE Randolph H. Stewart, DVM, Ph.D.

PRESENT POSITION AND ADDRESS Title: Clinical Professor Office: 307B VMS Phone: (979) 862-7764 Email: [email protected] Mailing address Parcel/Fed Ex address Veterinary Physiology & Pharmacology Vet. Physiology & Pharmacology Texas A&M University Highway 60 4466 TAMU Texas A&M University College Station, TX 77843-4466 VMA Bldg., Rm 332 College Station, TX 77843-4466 EDUCATION Degree/Training Conferring Institution Field Year Postdoc (G.A. Laine) Texas A&M University Microvasc. Physiology 1997-2000 PhD Texas A&M University Veterinary Physiology 1997

Dissertation title: Basic determinants of epicardial transudation MS The Ohio State University Veterinary Clin. Sci. 1989

Thesis title: Frequency and severity of osteochondrosis in horses with cervical stenotic myelopathy

Residency The Ohio State University Internal Medicine-LA 1986-1989 DVM Texas A&M University Veterinary Medicine 1983 BS, cum laude Texas A&M University Veterinary Science 1981 PROFESSIONAL EXPERIENCE AND ACADEMIC APPOINTMENTS 2015-present Director Link Equine Research Endowment Texas A&M University, College Station, TX 2013-present Clinical Professor Dept. Veterinary Physiology & Pharmacology Texas A&M University, College Station, TX 2005-2013 Clinical Associate Professor Dept. Veterinary Physiology & Pharmacology Texas A&M University, College Station, TX

mailto:[email protected]

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. 1999-2005 Research Assistant Professor Dept. Veterinary Physiology & Pharmacology Texas A&M University, College Station, TX 1996-1999 Lecturer Dept. Veterinary Physiology & Pharmacology Texas A&M University, College Station, TX 1994-1996 Veterinary Clinical Associate Dept. Veterinary Physiology & Pharmacology Texas A&M University, College Station, TX 1992-1994 Texas A&M University Regents Fellow Dept. Veterinary Physiology & Pharmacology Texas A&M University, College Station, TX 1989-1992 Randolph H. Stewart, DVM, P.C. Private consulting practice, San Antonio, TX 1986-1989 Clinical Instructor, Equine Medicine Dept. Veterinary Clinical Sciences The Ohio State University, Columbus, OH 1985-1986 Resident Veterinarian Lasma Arabians, Scottsdale, AZ 1983-1984 Clinical Associate Nielsen Equine Medical Group, Wichita, KS CLINICAL SPECIALTY/BOARD CERTIFICATION Diplomate, American College of Veterinary Internal Medicine Subspecialty: Internal Medicine, Large Animal AWARDS AND HONORS Charter Fellow, Michael E. DeBakey Institute, Comparative Cardiovascular Sci. Research Fellow, Cardiovascular Research Institute, Texas A&M Health Science Center Research Fellow, Center for Microvascular and Lymphatic Studies, UT Med School, Houston Excellence in Lymphatic Research, Microcirculatory Society, 2001 Distinguished Achievement Award in Teaching, Assoc. Former Students, 2001 Richard H. Davis Teaching Award, 1999 Texas A&M University Regents Fellowship, 1993 Texas A&M University Regents Fellowship, 1992 Phi Zeta Honor Society, 1986

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. AWARDS AND HONORS Phi Kappa Phi Honor Society, 1979 American Society of Animal Science Undergraduate Award, 1979 Phi Eta Sigma Honor Society, 1977 National Merit Scholar, 1976-1980 TEACHING EXPERIENCE My primary classroom teaching focus has been in the instruction of systems physiology for veterinary and graduate students. I have worked as part of a teaching team where I have been lecturer and laboratory coordinator since 1998 and course coordinator since 2012. Professional Credit % of Course Title Institution Hr Course Contact Dates VTPP 910 Physiology I TAMU 6 72% 94 hrs/yr 2012-present Course coordinator and laboratory coordinator VTPP 910 Physiology I TAMU 6 51% 66 hrs/yr 1998-2011 Laboratory coordinator VTPP 912 Physiology II TAMU 6 57% 60 hrs/yr 2012-present Course coordinator and laboratory coordinator VTPP 912 Physiology II TAMU 6 48% 64 hrs/yr 1999-2011 Laboratory coordinator VTPP 912 Physiology II TAMU 6 9% 12 hrs/yr 1997 VTPP 924 Pharmacology I TAMU 5 1% 8 hrs/yr 2008-2010 VTPP 924 Pharmacology I TAMU 5 31% 17 hrs/yr 2006-2007 VTPP 924 Pharmacology I TAMU 5 1% 8 hrs/yr 2000-2005 VTPP 924 Pharmacology I TAMU 5 42% 24 hrs/yr 1997 VTPP 948 Neonatology TAMU 1 10% 8 hrs/yr 1999-2005 VMID 912 Clin Correlates I TAMU 1 5% 4 hrs/yr 1998-2001 VMID 912 Clin Correlates I TAMU 1 60% 24 hrs/yr 1997 VMID 913 Clin Correlates II TAMU 1 5% 4 hrs/yr 1999-2001 VMID 913 Clin Correlates II TAMU 1 60% 24 hrs/yr 1998 Graduate Credit % of Course Title Institution Hr Course Contact Dates VTPP 610 Physiology I TAMU 6 72% 94 hrs/yr 2012-present Course coordinator and laboratory coordinator VTPP 610 Physiology I TAMU 6 51% 66 hrs/yr 1999-2011 Laboratory coordinator VTPP 612 Physiology II TAMU 6 57% 60 hrs/yr 2012-present Course coordinator and laboratory coordinator

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. Graduate Credit % of Course Title Institution Hr Course Contact Dates VTPP 612 Physiology II TAMU 6 48% 64 hrs/yr 2000-2011 Laboratory coordinator VTPP 605 Syst Vet Phys I TAMU 5 15% 10 hrs/yr 1998-2011 VTPP 605 Syst Vet Phys I TAMU 5 2% 1.5 hrs/yr 2014 VTPP 606 Syst Vet Phys II TAMU 5 5% 4 hrs/yr 1999-2011 VTPP 606 Syst Vet Phys II TAMU 5 21% 16 hrs/yr 2012 VTPP 655 Vascular Physiology TAMU 4 14% 4 hrs/yr 2008-2013 Undergraduate Course Title Institution Hr Course Contact Dates VTPP 423 Biomed Physiol I TAMU 4 23% 15 hrs/yr 2015 Much of my undergraduate teaching has focused on development of authentic research experiences. I have utilized both independent study and, more recently, team-based experiences. Students are provided a fundamental question in physiology and are encouraged to develop and test unique hypotheses. In all cases, the students investigate and report their findings in the form of abstracts, posters and, possibly, manuscripts. The rationale, methods and benefits of the team-based approached that I utilize are summarized in the abstract of the manuscript that my colleagues and I published on the use of research-intensive communities (Adv Physiol Educ 32: 136-141, 2008).

Although the Boyer Commission (1998) lamented the lack of research opportunities for all undergraduates at research-extensive universities, it did not provide a feasible solution consistent with the mandate for faculty to maintain sustainable physiology research programs. The costs associated with one-on-one mentoring, and the lack of a sufficient number of faculty members to give intensive attention to undergraduate researchers, make one-on-one mentoring impractical. We therefore developed and implemented the “research-intensive community” model with the aim of aligning diverse goals of participants while simultaneously optimizing research productivity. The fundamental organizational unit is a team consisting of one graduate student and three undergraduates from different majors, supervised by a faculty member. Undergraduate workshops, Graduate Leadership Forums, and computer-mediated communication provide an infrastructure to optimize programmatic efficiency and sustain a multilevel, interdisciplinary community of scholars dedicated to research. While the model radically increases the number of undergraduates that can be supported by a single faculty member, the inherent resilience and scalability of the resulting complex adaptive system enables a research-intensive community program to evolve and grow.

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. Director, Undergraduate Research in Quantitative Physiology This program allows interdisciplinary teams of Texas A&M undergraduates to utilize

a research-grade computational model of the cardiovascular system to explore novel questions in cardiovascular physiology. Each team is led by an undergraduate student with previous experience with the model. The teams report on their research via abstracts and poster presentations with the longer-term goal of writing and publishing a scientific manuscript.

Quantitative Physiology Fellows Ejection Fraction project 2014-15 Christopher Mason – group leader Biomedical Engineering Nga Tran – group leader Chemistry/Mathematics William Wilder Biomedical Sciences Amber Wilkerson Biomedical Sciences Steven Shao Biomedical Sciences Eustace Joseph Biomedical Sciences Samen Karim Biology Alyson Terry Biomedical Sciences Ventricular Wall Stress project 2014-15 Chinwe Nwokocha – group leader Biology Jared Schueler – group leader Industrial engineering Hunter Enderle – group leader Biomedical Sciences Thomas Slack Kinesiology Sydney Reese Biomedical Engineering Morgan Bannerman Biomedical Sciences Shreyas Reddy Chemical Engineering Michelle Villareal Biochemistry Toney Duong Biomedical Sciences David Westra Biomedical Sciences Kunal Shah Biomedical Sciences Patent Ductus Arterious project 2014-15 Humza Ahmed – group leader Biomedical Engineering Eyad Albaba Accounting Urvi Chikliya Biomedical Sciences Henna Khangura Biomedical Sciences Franklin Hise Biomedical Engineering Juzar Hussein Biomedical Sciences Michelle Hernandez Psychology Jasmine Carino Biomedical Sciences Suqrat Munawar Medical School

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. Co-Director, Michael E. DeBakey Summer Research Program, 2004-2010 This NIH and NSF-supported program introduced graduate and undergraduate

students in engineering and life sciences to novel research experiences using the bat wing as an animal model of a vascular network. During a 10-week summer session, the students formed interdisciplinary teams that designed, conducted and reported on experiments addressing fundamental questions in cardiovascular system behavior.

DeBakey Research Fellows Wade Eveland Chemical Engineering, LSU Brandon Gentry Biomedical Engineering, TAMU Joseph Lopez Biology, TAMU-Corpus Christi Sy Sy Huang Biomedical Engineering, TAMU Jennifer E. Laurinec Biomedical Engineering, TAMU Daniel R. Gilbert Biomedical Engineering, TAMU Joseph L. Dellinger Biomedical Engineering, TAMU Shamaine St. Julien Animal Science, TAMU Prairie View Kimberly Cook Animal Science, TAMU Prairie View Independent Undergraduate Research Fellows Students register for VTPP 285, 291, 485 or 491 to work in my research lab. They each

completed and reported on independent projects. Josh Meisner Biomedical Engineering 2002-2004 Ellen Walker (Honors) Biomedical Sciences 2000-2001 Ira Lehrer Biomedical Sciences 2000 Jennifer Elizondo Biomedical Sciences 2000 Paul Bertolino Biomedical Sciences 1999-2000 Khoi ‘Calvin’ Nguyen Biomedical Sciences 1999 Amanda Magee Biomedical Sciences 1999 Catherine Moler Biomedical Sciences 1998 Ashley Weber Biomedical Sciences 1998 Mike Latimer Biomedical Sciences 1998 Chris Eskew Biomedical Sciences 1997 Greg Bobo Biomedical Sciences 1997

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. Veterinary Research Fellows Veterinary students worked in my laboratory to gain research experience. Craig Quinlan Veterinary Medicine, TAMU 2005 Abraham Robinson II Veterinary Medicine, TAMU 2004 Jered Johnston Veterinary Medicine, TAMU 2004 Justin Cavitt Veterinary Medicine, TAMU 2004 Crystal Hoh Veterinary Medicine, TAMU 2004 Eric C. Cunningham Veterinary Medicine, TAMU 2003-2004 Aaron Rainer Veterinary Medicine, TAMU 2003-2004 Jennifer Brogan Veterinary Medicine, TAMU 2003 Chris Tarwater Veterinary Medicine, TAMU 2003 Matthew Evans Veterinary Medicine, TAMU 2001-2003 Graduate Mentoring Chair, Doctoral dissertation committee Tam L. Nguyen, PhD, Biomedical Sciences, 2013 Dissertation title: Lymphatic functional adaptations to prolonged changes in

transmural pressure and luminal flow Arun M. Venugopal, PhD, Biomedical Sciences, 2008 Dissertation title: Structural and functional characterization of a lymphatic system

using computational and experimental approaches Chair, Master’s thesis committee Bruce Ngo, MS, Biomedical Sciences, 2007 Thesis title: Stimulation of post-nodal lymphatic vessels inhibits flow under high flow

conditions Chair, Master’s committee (Non-thesis) Joshua Iltis, Biomedical Sciences, in progress Daniel Olson, Biomedical Sciences, in progress Scott Mash, Biomedical Sciences, in progress Taylor Schaar, MS, Biomedical Sciences, 2012 Krista Putty, MS, Biomedical Sciences, 2012 David Wilbur, MS, Biomedical Sciences, 2011 Olivia Masters, MS, Biomedical Sciences, 2010 Member, Doctoral dissertation committee Thomas Stiles, Biomedical Sciences, in progress Travis Mays, Biomedical Sciences, in progress Sarah Coquis-Knezek, Biomedical Sciences, in progress Phuc Nguyen, PhD, Biomedical Sciences, 2014 Shannon Wilson, PhD, Biomedical Sciences, 2010

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. Member, Doctoral dissertation committee Ranjeet Dongaonkar, PhD, Biomedical Sciences, 2008 Ketaki Desai, PhD, Biomedical Sciences, 2007 Ahkilesh Kotiya, PhD, Biomedical Engineering, 2007 Member, Master’s thesis committee Pamela Osborn, MS, Biomedical Sciences, 2014 Philippa Sprake, MS, Biomedical Sciences, 2012 Joshua K. Meisner, MS, Biomedical Engineering, 2006 Shruti Rajagopalan, MS, Biomedical Engineering, 2005 Arun Venugopal, MS, Biomedical Engineering, 2005 Member, Master’s committee (Non-thesis) Michael Overby, Biomedical Sciences, in progress Benjamin Schwarz, Biomedical Sciences, in progress Summer Johnson, MS, Biomedical Sciences, 2015 Cara Martin, MS, Biomedical Sciences, 2014 Chris Sheppard, MS, Biomedical Sciences, 2013 Ashley Navarrette, MS, Biomedical Sciences, 2013 Roxanna Ocana, MS, Biomedical Sciences, 2013 Cody Martin, MS, Biomedical Sciences, 2013 Kyle Countryman, MS, Biomedical Sciences, 2012 Julia Buck, MS, Biomedical Sciences, 2012 Bethany Dwyer, MS, Biomedical Sciences, 2011 Markay Wilson, MS, Biomedical Sciences, 2011 Stephenie Kilgore, MS, Biomedical Sciences, 2010 Marina McDew, MS, Biomedical Sciences, 2010 Chase Crawford, MS, Biomedical Sciences, 2010 Bryon Jennings, MS, Biomedical Sciences, 2010 Stephanie Rasco, MS, Biomedical Sciences, 2008 Other graduate student training Stephanie Cerovsky, 2011-2012 Melanie Wortley, 2011-2012 Wonjun Wang, 2006-2007 Annika Linde, 2003-2004 Faculty Mentoring Shannon Washburn, 2015-present Ivan Ivanov, 2015-present

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. RESEARCH/SCHOLARLY ACTIVITIES Pending Research Funding National Science Foundation; “STEM Scholarships to participate in a research-intensive community at Texas A&M”; RH Stewart (Co-PI), CM Quick (PI); 7/1/15-7/1/19; Total cost: $596,024. R01 DK107891-01; National Institutes of Health; “Identification of Mechanisms of Edemagenic Insult Induced Lymphatic Pump Failure”; RH Stewart (Co-I; 3%), RM Dongaonkar (PI); 9/1/15-8/31/19; Direct cost: $1,009,553. Current Research Funding R01 HL094269; National Institutes of Health; “Lymphatic fluid flow modeling with active network components”; RH Stewart (Co-I; 7.5%), R Kaunas (PI); 9/1/09-6/30/15; Total cost: $2,728,034. CMMI-1063954; National Science Foundation; “Structural adaptation of microvascular networks to mechanical stimuli”; RH Stewart (Co-PI; 2 mo), CM Quick (PI); 9/1/11-8/31/15; Total cost: $398,748. Completed Research Funding R01 HL092916; National Institutes of Health; “Short-term mesenteric lymphatic adaptation to trauma-related intestinal edema”; RH Stewart (PI; 20%); E Wilson (PI); 9/1/09-8/31/12; Total cost: $883,345. 10PRE3040051; Predoctoral fellowship; American Heart Association South Central Affiliate; “Biomechanical aspects of functional adaptations in lymphatic vessels”; TL Nguyen (PI) RH Stewart (Sponsor); 7/1/10-6/30/12; Total cost: $50,000. 10GRNT4320043; Grant-in-aid; American Heart Association South Central Affiliate; “Batwing as a novel model for cardiovascular radiobiology: Vascular contribution to radiation-induced edema”; RH Stewart (Co-I; 1 mo); CM Quick (PI); 7/1/10-6/30/12; Total cost: $140,000. NSF 0609395; National Science Foundation; “BBSI: Vascular bioengineering summer institute” RH Stewart (Co-PI), CM Quick (PI); 5/1/06-4/30/11; Total cost: $600,000. NSF 0552902; National Science Foundation; “REU site: Mechanobiology of the bat wing microvasculature” RH Stewart (Co-PI), CM Quick (PI); 3/1/06-8/31/10; Total cost: $265,000.

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. POE-03-08; Life Sciences Task Force – Texas A&M University; “Mechanisms of edema resolution: Implications for treatment of cardiovascular disease”; RH Stewart (Co-I), GA Laine (PI); 7/1/03-6/30/07; Total cost: $400,000. AHA 0365127Y; American Heart Association, Texas Affiliate; “Stimulation and inhibition of the lymphatic pump: Implications for lymph flow and edema”; RH Stewart (PI); 7/1/03-6/30/05; Total cost: $124,000. ARP 000517-0149-2001 Suppl; Texas Higher Education Coordinating Board Advanced Research Program; Supplement to “Anti-edema mechanisms: Nitric oxide and thromboxane in the regulation of lymphatic function”; RH Stewart (PI); 2002 (9 weeks); Total cost: $8100. ARP 000517-0149-2001; Texas Higher Education Coordinating Board Advanced Research Program; “Anti-edema mechanisms: Nitric oxide and thromboxane in the regulation of lymphatic function”; RH Stewart (PI); 7/1/02-6/30/03; Total cost: $95,674. SP-300-015; TAMU College of Veterinary Medicine Signature Programs; “Synovial lymphatic function in horses: Implications for arthritis”; RH Stewart (PI); 2000-2002; Total cost: $19,313. SP-499-005; TAMU College of Veterinary Medicine Signature Programs; Cardiovascular Research Training Grant; RH Stewart (Co-I), GA Laine (PI); 1999-2002; Total cost: $120,000. Bayer A.G., “Evaluation of Ecadotril as a single therapeutic agent for the treatment of congestive heart failure induced by rapid pacing in dogs” RH Stewart (Co-I), MW Miller (PI); 1/1/98-12/31/98; Total cost: $398,492. The Ohio State University, College of Veterinary Medicine, Equine Research Program, “Frequency and severity of osteochondrosis in horses with cervical stenotic myelopathy” RH Stewart (PI), 7/1/88-6/31/89; Total cost: $10,000. Professional Development Peer Review Project

Texas A&M Center for Teaching Excellence, 2004-2005 Participated with other university faculty in a yearlong review of teaching methods

including development of a teaching portfolio Scholarship of Teaching & Learning

Texas A&M Center for Teaching Excellence, 2005-2006 Participated with other university faculty in a yearlong review of classroom research

methods including development and completion of a research project assessing the evaluation of quantitative skills in physiology

Search committee chairman, Texas A&M University – 2008, 2011, 2013

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. Professional Development Diversity Training Institute, Texas A&M University – 2014 Basic Mediator certificate (40 hours), Texas A&M University - 2015 BIBLIOGRAPHY Publications in Refereed Journals Bold lettering indicates an undergraduate coauthor. 1. Stewart RH and Robertson JT. Surgical stapling for repair of a rectal tear in a horse.

J Am Vet Med Assoc 197 (6): 746-748, 1990. PMID: 2211325 2. Stewart RH, Reed SM, Weisbrode SE. Complications associated with alcohol tail-

blocks in three horses. Prog Vet Neurol 1 (4): 476-480, 1990. 3. Stewart RH, Reed SM, Weisbrode SE. The frequency and severity of osteochondrosis

in horses with cervical stenotic myelopathy. Am J Vet Res 52 (6): 873-879, 1991. PMID: 1883090

4. Hardy J, Stewart RH, Beard WL, Yvorchuk-St Jean K. Complications of nasogastric intubation in horses: 9 cases (1987-1989). J Am Vet Med Assoc 201 (3): 483-486, 1992. PMID: 1506260

5. Stewart RH, Bertone JJ, Yvorchuk-St Jean K, Reed SM, Neil WH. Possible normokalemic variant of hyperkalemic periodic paralysis in two horses. J Am Vet Med Assoc 203 (3): 421-424, 1993. PMID: 8226220

6. Rohn DA, Stewart RH, Elk JR, Laine GA, Drake RE. Renal lymphatic function following venous pressure elevation. Lymphology 29: 67-75, 1996. PMID: 8823729

7. Stewart RH, Rohn DA, Mehlhorn U, Davis KL, Allen SJ, Laine GA. Regulation of microvascular filtration in the myocardium by interstitial fluid pressure. Am J Physiol Regul Integra Comp Physiol 271 (40): R1465-R1469, 1996. PMID: 8997340

8. Stewart RH, Rohn DA, Allen SJ, Laine GA. Basic determinants of epicardial transudation. Am J Physiol Heart Circ Physiol 273 (42): H1408-H1414, 1997. PMID: 9321832

9. Stewart RH, Geissler HJ, Allen SJ, Laine GA. Protein washdown as a defense mechanism against myocardial edema. Am J Physiol Heart Circ Physiol 279 (4): H1864-H1868, 2000. PMID: 11009474

10. Stewart RH. The case for measuring plasma colloid osmotic pressure. J Vet Intern Med 14: 473-474, 2000. PMID: 11012106

11. Stewart RH and Laine GA. Flow in lymphatic networks: Interaction between hepatic and intestinal lymph vessels. [Winner of Microcirculatory Society Award for Excellence in Lymphatic Research] Microcirculation 8: 221-227, 2001. PMID: 11528530

12. Fischer UM, Cox CS, Allen SJ, Stewart RH, Mehlhorn U, Laine GA. The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest. J Thorac Cardiovasc Surg 126(5): 1483-1488, 2003. PMID: 14666023

13. Stewart RH, Allen SJ, Quick CM, Rohn DA, Cox CS, Laine GA. Effect of venous air

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D.

embolization on pulmonary microvascular protein permeability. Microcirculation 11(5): 411-416, 2004. PMID: 15280066

14. Venugopal AM, Stewart RH, Rajagopalan S, Laine GA, Quick CM. Optimal lymphatic vessel structure. Conf Proc IEEE Eng Med Biol Soc 5: 3700-3703, 2004. PMID: 17271097

15. Moore-Olufemi SD, Xue H, Attuwaybi BO, Harari Y, Oliver DH, Weisbrodt N, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS. Resuscitation-induced gut edema and intestinal dysfunction. J Trauma 58 (2): 264-270, 2005. PMID: 15706186

16. Moore-Olufemi SD, Xue H, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS. Effects of primary and secondary intra-abdominal hypertension on mesenteric lymph flow: implications for the abdominal compartment syndrome. Shock 23 (6): 571-575, 2005. PMID: 15897812

17. Moore-Olufemi SD, Xue H, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS. Inhibition of intestinal transit by resuscitation-induced gut edema is reversed by L-NIL. J Surg Res 129 (1): 1-5, 2005. PMID: 15978623

18. Quick CM, Berger DS, Stewart RH, Laine GA, Hartley CJ, Noordergraaf A. Resolving the hemodynamic inverse problem. IEEE Trans Biomed Eng 53 (3): 361-368, 2006. PMID: 16532762

19. Fischer UM, Cox CS, Stewart RH, Laine GA, Allen SJ. Impact of acute myocardial edema on left ventricular function. J Invest Surg 19 (1): 31-38, 2006. PMID: 16546927

20. Stewart RH, Quick CM, Zawieja DC, Cox CS, Allen SJ, Laine GA. Pulmonary air embolization inhibits lung lymph flow by increasing lymphatic outflow pressure. Lymphat Res Biol 4 (1): 18-22, 2006. PMID: 16569202

21. Quick CM, Venugopal AM, Gashev AA, Zawieja DC, Stewart RH. Intrinsic pump-conduit behavior of lymphangions. Am J Physiol Regul Integra Comp Physiol 292: R1510-R1518, 2007. PMID: 17122333

22. Widmer RJ, Stewart RH, Young MF, Laurinec JE, Laine GA, Quick CM. Application of local heat induces capillary recruitment in the pallid bat wing. Am J Physiol Regul Integra Comp Physiol 292: R2312-R2317, 2007. PMID: 17332157

23. Meisner JK, Stewart RH, Laine GA, Quick CM. Lymphatic vessels transition to state of summation above a critical frequency. Am J Physiol Regul Integra Comp Physiol 293: R200-R208, 2007. PMID: 17363681

24. Venugopal AM, Stewart RH, Laine GA, Dongaonkar RM, Quick CM. Lymphangion coordination minimally affects mean flow in lymphatic vessels. Am J Physiol Heart Circ Physiol 293: H1183 - H1189, 2007. PMID: 17468331

25. Gashev AA, Wang W, Laine GA, Stewart RH, Zawieja DC. Characteristics of the active lymph pump in bovine prenodal mesenteric lymphatics. Lymphat Res Biol 5 (2): 71-80, 2007. PMID: 17935475

26. Dongaonkar RM, Quick CM, Stewart RH, Laine GA. Edemagenic gain and interstitial fluid volume regulation. Am J Physiol Regul Integra Comp Physiol 294: R651-R659, 2008. PMID: 18056984

27. Stewart RH, Uray K, Cox CS, Laine GA. Myocardial fluid balance in dogs with naturally acquired heartworm infection. Am J Vet Res 69 (3): 356-361, 2008. PMID: 18312134

28. Cox CS, Radhakrishnan R, Villarubia L, Xue H, Uray K, Gill BS, Stewart RH, Laine GA.


Hypertonic saline modulation of intestinal tissue stress and fluid balance. Shock 29 (5): 598-602, 2008. PMID: 18414233

29. Quick CM, Venugopal AM, Dongaonkar RM, Laine GA, Stewart RH. First-order approximation for the pressure-flow relationship of spontaneously contracting lymphangions. Am J Physiol Heart Circ Physiol 294: H2144-H2149, 2008. PMID: 18326809

30. Desai KV, Laine GA, Stewart RH, Cox CS, Quick CM, Allen SJ, Fisher UM. Mechanics of the left ventricular myocardial interstitium: Effects of acute and chronic myocardial edema. Am J Physiol Heart Circ Physiol 294: H2428-H2434, 2008. PMID: 18375722

31. Desai KV, Gatson SN, Stiles TW, Stewart RH, Laine GA, Quick CM. Integrating research and education at research-extensive universities with research-intensive communities. Adv Physiol Educ 32: 136-141, 2008. PMID: 18539852

32. Venugopal AM, Quick CM, Laine GA, Stewart RH. Optimal post-nodal lymphatic network structure that maximizes active propulsion of lymph. Am J Physiol Heart Circ Physiol 296: H303-H309, 2009. PMID: 19028799

33. Quick CM, Ngo B, Venugopal AM, Stewart RH. Lymphatic pump-conduit duality: contraction of post-nodal lymphatic vessels inhibits passive flow. Am J Physiol Heart Circ Physiol 296: H662-H668, 2009. PMID: 19122167

34. Dongaonkar RM, Stewart RH, Bogenschutz R, Laine GA, Davis MJ, Quick CM. Venomotion modulates the lymphatic pumping in the bat wing. Am J Physiol Heart Circ Physiol 296: H2015 - H2021, 2009. PMID: 19329767

35. Dongaonkar RM, Laine GA, Stewart RH, Quick CM. Balance point characterization of interstitial fluid volume regulation. Am J Physiol Regul Integra Comp Physiol 297: R6-R16, 2009. PMID: 19420292

36. Moore-Olufemi SD, Padelecki J, Olufemi SE, Xue H, Oliver DH, Radhakrishnan RS, Allen SJ, Moore FA, Stewart R, Laine GA, Cox CS. Intestinal edema: Effect of enteral feeding on motility and gene expression. J Surg Res 155: 283-292, 2009. PMID: 19482297

37. Radhakrishnan RS, Shah SK, Lance SL, Radhakrishnan HR, Xue H, Radhakrishnan GL, Ramaswamy US, Walker PA, Uray KS, Laine GA, Stewart RH, Cox CS. Hypertonic saline alters hydraulic conductivity and up-regulates mucosal/submucosal aquaporin 4 in resuscitation-induced intestinal edema. Crit Care Med 37(11): 2946-2952, 2009. PMID: 19770732

38. Shah SK, Jimenez F, Walker PA, Xue H, Uray KS, Aroom KR, Fischer UM, Laine GA, Stewart RH, Norbury KC, Cox CS. A novel physiologic model for the study of abdominal compartment syndrome (ACS). J Trauma 68(3): 682-689, 2010. PMID: 20220423

39. Shah SK, Fogle LN, Aroom KR, Gill BS, Moore-Olufemi SD, Jimenez F, Uray KS, Walker PA, Stewart RH, Laine GA, Cox CS. Hydrostatic intestinal edema-induced signaling pathways: potential role of mechanical forces. Surgery 147(6): 772-779, 2010. PMID: 20097396

40. Shah SK, Xue H, Jimenez F, Kots AY, Choi B-K, Uray KS, Walker PA, Moore-Olufemi SD, Velez N, Stewart RH, Laine GA, Cox CS. Evaluating the potential role of nitric oxide as a mediator of hydrostatic edema mediated intestinal contractile dysfunction. J


Surg Res 163(1): 102-109, 2010. PMID: 20605598 41. Shah SK, Jimenez F, Walker PA, Aroom KR, Xue H, Feeley TD, Uray KS, Norbury KC,

Stewart RH, Laine GA, Cox CS. A novel mechanism for neutrophil priming in trauma: potential role of peritoneal fluid. Surgery 148(2): 263-270, 2010. PMID: 20466401

42. Dongaonkar RM, Stewart RH, Geissler HJ, Laine GA. Myocardial microvascular permeability, interstitial edema, and compromised cardiac function. Cardiovasc Res 87(2): 331-339, 2010. PMID: 20472566

43. Shah SK, Moore-Olufemi SD, Uray KS, Jimenez F, Walker PA, Xue H, Stewart RH, Laine GA, Cox CS. A murine model for the study of edema-induced intestinal contractile dysfunction. Neurogastroenterol Motil 22(10): 1132-e290, 2010. PMID: 20591104

44. Venugopal AM, Stewart RH, Laine GA, Quick CM. Nonlinear lymphangion pressure-volume relationship minimizes edema. Am J Physiol Heart Circ Physiol 299(3): H876-H882, 2010. PMID: 20601461

45. Shah SK, Uray KS, Stewart RH, Laine GA, Cox CS. Resuscitation-induced intestinal edema and related dysfunction: State of the science. J Surg Res 166(1): 120-30, 2011. PMID: 19959186

46. Uray KS, Shah SK, Radhakrishnan R, Jimenez F, Walker PA, Stewart RH, Laine GA, Cox CS. Sodium-hydrogen exchanger as a mediator of hydrostatic edema-induced intestinal contractile dysfunction. Surgery 149(1): 114-25, 2011. PMID: 20553904

47. Ramadoss J, Stewart RH, Cudd TA. Acute renal response to rapid onset respiratory acidosis. Can J Physiol Pharmacol 89(3): 227-231, 2011. PMID: 21423296

48. Dongaonkar RM, Laine GA, Stewart RH, Quick CM. Evaluation of gravimetric techniques to estimate the microvascular filtration coefficient. Am J Physiol Regul Integra Comp Physiol 300(6): R1426-R1436, 2011. PMID: 21346245

49. Shah SK, Jimenez F, Walker PA, Xue H, Feeley TD, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS. Peritoneal fluid: a potential mechanism of systemic neutrophil priming in experimental intra-abdominal sepsis. Am J Surg 203(2): 211-16, 2012. PMID: 21679918

50. Shah SK, Jimenez F, Walker PA, Xue H, Feeley TD, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS Jr. Evaluating the effects of immediate application of negative pressure therapy after decompression from abdominal compartment syndrome in an experimental porcine model. European Journal of Trauma and Emergency Surgery 38(1): 65-73, 2012.

51. Chu J, Miller CT, Kislitsyna K, Laine GA, Stewart RH, Cox CS, Uray KS. Decreased myosin phosphatase target subunit 1 (MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle. Neurogastroenterol Motil 24(3): 257-66, 2012. PMID: 22235829

52. Shah SK, Jimenez F, Letourneau PA, Walker PA, Moore-Olufemi SD, Stewart RH, Laine GA, Cox CS. Strategies for modulating the inflammatory response after decompression from abdominal compartment syndrome. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 20: 25, 2012. PMID: 22472164

53. Dongaonkar RM, Quick CM, Vo JC, Meisner JK, Laine GA, Davis MJ, Stewart RH. Blood flow augmentation by intrinsic venular contraction in vivo. Am J Physiol Regul Integr Comp Physiol 302(12): R1436-R1442, 2012. PMID: 22513742

54. Dongaonkar RM, Stewart RH (corresponding author), Quick CM, Uray K, Cox CS,


Laine GA. Time course of myocardial interstitial edema resolution and associated left ventricular dysfunction. [Winner of Microcirculatory Society Award for Excellence in Lymphatic Research] Microcirculation 19: 714–722, 2012. PMID: 22708850

55. Chu J, Pham NT, Olate N, Kislitsyna K, Day M-C, LeTourneau PA, Kots A, Stewart RH, Laine GA, Cox CS, Uray K. Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility. Journal of Biologic Chemistry 288(2): 1200-1213, 2013. PMID: 23161543

56. Dongaonkar RM, Nguyen TL, Quick CM, Hardy J, Laine GA, Wilson E, Stewart RH. Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure. Am J Physiol Heart Circ Physiol 305(2): H203-H210, 2013. PMID: 23666672

57. Quick CM, Criscione JC, Kotiya A, Dongaonkar RM, Hardy J, Wilson E, Gashev AA, Laine GA, Stewart RH. Functional adaptation of bovine mesenteric lymphatic vessels to mesenteric venous hypertension. Am J Physiol Regul Integr Comp Physiol 306(12): R901-907, 2014. PMID: 24671245

58. Dongaonkar RM, Nguyen TL, Quick CM, Heaps CL, Hardy J, Laine GA, Wilson E, Stewart RH. Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps. Am J Physiol Heart Circ Physiol 308(5): R391-9, 2015. PMID: 25519727

Theses and Dissertations 1. Stewart RH. The frequency and severity of osteochondrosis in horses with cervical

stenotic myelopathy. MS Thesis. The Ohio State University, 1989. 2. Stewart RH. Basic determinants of epicardial transudation. PhD Dissertation. Texas

A&M University, 1997. Poster Presentations with Abstracts Bold lettering indicates an undergraduate coauthor. 1. Reed S, Knight D, Weisbrode S, Stewart R. The relationship of cervical vertebral

malformation to developmental orthopedic disease. Proc Am Assoc Eq Pract 33: 139-142, 1987

2. Davis K, Stewart R, Warters D, Laine G, Allen S. Pulmonary hypertension and left ventricular function. FASEB J. 7:A882, 1993.

3. Stewart R, Rohn D, Mehlhorn U. Davis K, Allen S, Laine G. Pericardial effusion and myocardial edema. Microcirculation 2 (1): 111, 1995.

4. Stewart R, Rohn D, Mehlhorn U, Davis K, Allen S, Laine G. Basic determinants of epicardial fluid transudation. FASEB J 10(3): A52, 1996.

5. Rohn D, Stewart R, Mehlhorn U, Davis K, Allen S, Laine G. The effects of myocardial edema-induced collagen synthesis on left ventricular function. Microcirculation 3(1): 103, 1996.

6. Rohn D, Stewart R, Allen S, Laine G. Resolution of acute coronary venous hypertension and its impact on myocardial edema and left ventricular function. FASEB J 11(3): A500, 1997.

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. 7. Stewart R, Allen S, Laine G. Protein washdown as a protective mechanism against

myocardial edema. FASEB J 13(4). A5, 1999. 8. Stewart R, Hooper N, Allen S, Laine G. Lymphatic drainage of synovial joints in

sheep. FASEB J 13(4): A87, 1999. 9. Stewart R, Miller M, Bonagura J, Turk J, Laine G. The effect of a neutral

endopeptidase inhibitor (NEPi) and rapid pacing on the myocardium. Exp. Biol. Program Addendum 2000.

10. Laine G, Stewart R, Allen S. The effect of physiologic albumin and hyaluronan concentrations on fluid resistance. Exp. Biol Program Addendum 2000.

11. Stewart R and Laine G. Flow in lymphatic networks; interaction between hepatic and intestinal lymph vessels. FASEB J 15 (4): A46, 2001.

12. Fischer U, Cox C, Mehlhorn U, de Vivie E, Stewart RH, Laine G, Allen S. Impact of acute myocardial edema on left ventricular function. FASEB J 16(5): A1128, 2002.

13. Stewart R, Rohn D, Fischer U, Cox C, Allen S, Criscione J, Laine G. Alterations in cardiac and vascular function curves following resolution of acute myocardial edema. FASEB J 16(5): A1128, 2002

14. Fischer U, Allen S, Cox C, Stewart R, Laine G. Effects of chronic and acute myocardial edema on left ventricular interstitial pressure and chamber compliance. FASEB J 16(5): A1128, 2002.

15. Cox CS, Moore FA, Stewart RH, Laine GA, Fischer U, Allen SJ, and Weisbrodt N. Gut edema causes ileus. Crit Care Med 30 (12 Suppl): A148, 2002.

16. Quick C, Stewart R, Criscione J, and Laine G. Passive flow in edema explains the discrepancy between calculated and measured lymph flow in contracting lymphatic vessels. FASEB J 17(4): A129, 2003.

17. Stewart R, Quick C, Criscione J, Cox C, Allen S, and Laine G. The effect of nitric oxide on lymphatic function depends on the axial pressure gradient. FASEB J 17(4): A128, 2003.

18. Quick C, Stewart R, Criscione J, Cox C, Allen S, and Laine G. Lymphangion pumping can decrease lymph flow in edema: preliminary model predictions. FASEB J 17(4): A129, 2003.

19. Stewart R, Quick C, Criscione J, Cox C, Allen S, and Laine G. Hypothermia inhibits lymphatic pumping. FASEB J 17(4): A128, 2003.

20. Quick C, Zawieja D, Stewart R, and Laine G. Applying time-varying elastance to lymphatic vessels. Proceedings of 2003 Annual Meeting of HSMBE, 2003.

21. Rajagopalan S, Stewart R, Venugopal A, Zawieja D, Laine G, and Quick C. Evaluating the time-varying elastance concept for lymphangions. Proceedings 25th Annual International Meeting of IEEE/EMB Society, Cancun, Mexico, 2003.

22. Venugopal A, Stewart R, Rajagopalan S, Zawieja D, Laine G, and Quick C. Applying the time-varying elastance concept to determine optimum coordination in a lymphatic vessel. Proceedings 25th Annual International Meeting of IEEE/EMB Society, Cancun, Mexico, 2003.

23. Desai KV, Young MF, Stewart RH, Quick CM. Noninvasive characterization of vascular network structure and function in the bat wing. Proceedings of 21st Annual Houston Conference on Biomedical Engineering Research, Houston, TX, February 12-13, 2004.

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. 24. Venugopal AM, Stewart RH, Laine GA, Rajagopalan S, Quick CM. Dis-coordination

of lymphangion pumping in lymphatic vessels. Proceedings of 21st Annual Houston Conference on Biomedical Engineering Research, Houston, TX, February 12-13, 2004.

25. Rajagopalan S, Venugopal AM, Stewart RH, Desai KV, Laine GA, Quick CM. Optimal diastolic period for lymphangion contraction. Proceedings of 21st Annual Houston Conference on Biomedical Engineering Research, Houston, TX, February 12-13, 2004.

26. Desai KV, Xu F, Young MF, Stewart RH, Quick CM. Pulsatile blood flow in the bat wing microvasculature. Exp. Biol. Program Addendum, 2004.

27. Venugopal AM, Stewart RH, Rajagopalan S, Desai KV, Laine GA, Quick CM. Lymphatic pump efficiency. FASEB J 18(4): A657-658, 2004.

28. Mohiuddin MW, Quick CM, Desai KV, Rajagopalan S, Laine GA, Stewart RH. Collapsible behavior in non-collapsing vessels: implications for lymph flow. FASEB J 18(4): A657, 2004.

29. Quick CM, Zawieja DC, Gashev AA, Stewart RH, Laine GA. Modeling strategies for optimizing lymph flow. Exp. Biol. Program Addendum, 2004.

30. Moore-Olufemi SD, Xue H, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS. Gut edema alters expression of tight junction proteins. Clinical Congress Owen H. Wangensteen Surgical Forum 199 (3S): S39, 2004.

31. Moore-Olufemi SD, Xue H, Allen SJ, Oliver DH, Moore FA, Weisbrodt N, Stewart R, Laine G, Cox CS. Inhibition of intestinal transit by resuscitation-induced gut edema is reversed by administration of L-NIL. Journal of Surgical Research, 121 (2): 334, 2004.

32. Meisner J, Stewart RH, Quick CM. Characterization of vessel behavior with both classical arterial and ventricular mechanics. BMES 2004 Annual Fall Meeting. Philadelphia, 2004.

33. Venugopal AM, Quick CM, Rajagopalan S, Stewart RH. Increased lymphangion pumping frequency can compensate for an increased afterload. BMES 2004 Annual Fall Meeting. Philadelphia, 2004.

34. Widmer RJ, Stewart RH, Quick CM, Laine GA. Michael E. DeBakey Summer Research Program. Proceedings of 2nd annual TAMUS Pathways Research Symposium, Corpus Christi, TX, 2004.

35. Desai KV, Cunningham CE, Stewart RH, Quick CM. Developing a novel animal model to study angiogenesis and angioadaptation. Proceedings of 2nd Annual TAMUS Pathways Research Symposium, Corpus Christi, TX, 2004.

36. Dongaonkar R, Johnston J, Quick CM, Stewart RH. Novel noninvasive technique for in vivo measurement of changes in tissue fluid volume. Proceedings of 2nd Annual TAMUS Pathways Research Symposium, Corpus Christi, TX, 2004.

37. Laurinec J, Widmer RJ, Venugopal A, Rainer A, Quick CM, Stewart RH. Lymphatic vessel pumping increases with temperature: in vivo study with Pallid bats. Proceedings of 2nd Annual TAMUS Pathways Research Symposium, Corpus Christi, TX, 2004.

38. Venugopal AM, Vasquez MC, Lee JC, Stewart RH, Quick CM. Increases in filling pressure and afterload results in lymphangion pump failure. 23nd Annual Houston Conference in Biomedical Research, February 9-10 2005.

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. 39. Stewart R, Gashev A, Stallone J, Zawieja D, Wilson E, Criscione J, Hardy J, Laine G,

Quick C. Lymphatic vessel contraction impedes flow under high flow conditions. FASEB J 19(4): A166, 2005.

40. Uray K, Allen S, Laine G, Stewart R, Radhakrishnan R, Cox C. Intestinal edema reduces intestinal motility through decreased myosin light chain phosphorylation. FASEB J 19(4): A744, 2005.

41. Wang W, Gashev A, Stewart R, Hardy J, Greiner S, Quick C, Laine G, Zawieja D. Influence of acute experimental edema on pumping of bovine mesenteric prenodal lymphatics. FASEB J 19(4): A166, 2005.

42. Gashev A, Wang W, Stewart R, Greiner S, Quick C, Laine G, Zawieja D. Contractile characteristics of bovine mesenteric prenodal lymphatics. FASEB J 19(4): A166, 2005.

43. Ngo B, Hardy J, Zawieja D, Gashev A, Wilson E, Criscione J, Stallone J, Quick C, Laine G, Stewart R. Lymphatic vessel function adapts to high flow conditions. FASEB J 19(4): A165, 2005.

44. Venugopal AM, Hegde B, Nguyen P, Stewart RH, Quick CM. Visible light stimulates microlymphatic pumping in the bat wing. Experimental Biology 2005, San Diego, CA, April 2-6, 2005. FASEB LB 13-14, 2005.

45. Kotiya A, Wilson E, Zawieja D, Gashev A, Stallone J, Hardy J, Quick C, Stewart R, Laine G, Criscione J. Geometric changes in mesenteric lymphatic vessels following intestinal edema. FASEB J 19(4): A165, 2005.

46. Quick C, Stewart R, Hardy J, Gashev A, Wilson E, Criscione J, Stallone J, Zawieja D, Laine G. Texas A&M University System Program for Excellence in Life Sciences: A new paradigm for lymphatic vessel research. FASEB J 19(4): A167, 2005.

47. Meisner J, Stewart R, Quick C, Laine G. Lymphatic myogenic response decreases pumping. FASEB J 19(4): A166, 2005.

48. Laurinec JE, Widmer RJ, Kuriachan VP. Ali JT, Dreiss AD, Turner V, Venugopal AM, Quick CM, Stewart RH. Heat increases microlymphatic pumping activity in vivo. FASEB J 19(4): A169, 2005.

49. Moore-Olufemi SD, Padalecki, Xue H, Radhakrishnan R, Allen SJ, Moore FA, Stewart R, Laine G, Cox CS. Early enteral nutrition improves gut edema associated ileus. ACS 201 (3): S32 Suppl. S, 2005.

50. Kuriachan VP, Widmer RJ, Laurinec JE, Stewart RH, Quick CM. Relating the physics and physiology of thermoregulation. Proceedings of HSEMB, 126, 2005.

51. Dongaonkar RM, Bogenschutz R, Stewart RH, Quick CM. A novel model to repeatedly characterize the effect of interstitial tethering on vascular function. Proceedings of HSEMB, 128, 2005.

52. Mohiuddin MW, Gilbert D, Brown T, Guevara N, Browning J, Stewart RH, Quick CM. The myogenic response regulates both shear stress and pulse wave transmission at arteriolar bifurcation. Proceedings of HSEMB, 69, 2005.

53. Dongaonkar R, Bogenschutz RA, Stewart RH, Quick CM. Characterization of the mechanical coupling of microvasculature and interstitium in vivo. FASEB J 19(4): A729, 2005.

54. Dongaonkar R, Bogenschutz R, Stewart RH, Quick CM. Characterization of the mechanical coupling of microvasculature and interstitium in vivo. Third Annual


TAMUS Pathways Research Symposium, Kingsville, TX, November 4-5, 2005. TAMUS 3: 55, 2005.

55. Meisner JK, Stewart RH, Quick CM, Laine GA. Lymphatic myogenic response can decrease pumping. Third Annual TAMUS Pathways Research Symposium, Kingsville, TX, November 4-5, 2005. TAMUS 3: 57, 2005

56. Ngo B, Hardy J, Zawieja D, Gashev A, Wilson E, Criscione J, Stallone J, Quick CM, Laine GA, Stewart RH. Lymphatic vessel function adapts to high flow conditions. TAMU Student Research Week, College Station, TX, March 28, 2005. TAMU SRW 95, 2005.

57. Dao SH, Quick CM, Meisner JK, Hsu CC, Ngo BL, Venugopal AM, Crannell Z, Stewart RH. Lymphatic muscle is weaker than both cardiac and blood vessel muscle. TAMU Student Research Week, College Station, TX, March 28, 2005. TAMU SRW 136-137, 2005.

58. Venugopal A, Stewart RH, Rajagopalan S, Laine GA, Quick CM. Optimal lymphatic vessel structure. TAMU Student Research Week, College Station, TX, March 28, 2005. TAMU SRW 263-264, 2005.

59. Widmer RJ, Laurinec JE, Kuriachan VP, Stewart RH, Quick CM. Vasodilation of the bat wing microcirculation with local heat. TAMU Student Research Week, College Station, TX, March 28, 2005. TAMU SRW 273-274, 2005.

60. Widmer RJ, Dongaonkar R, Meisner JK, Laurinec JE, Zawieja DC, Stewart RH, Quick CM. Venomotion propels lymph in the Pallid bat wing. FASEB J A169, 2005.

61. Widmer RJ, Laurinec JE, Young MF, Stewart RH, Quick CM. Shear stress contribution to the neurally-mediated portion of the biphasic vasodilatory response following the application of local heat in skin microcirculation. Circulation 112 (17): U267-U268 1095 Suppl. S, Oct 25 2005.

62. Widmer RJ, Laurinec JE, Young MF, Stewart RH, Quick CM. Spatial and temporal arrangements define the structural and functional aspects of the biphasic vasodilatory response to the application of local heat. AMA-MSS Interim Meeting, November 4, 2005.

63. Widmer RJ, Laurinec JE, Young MF, Stewart RH, Quick CM. Vasodilation of the bat wing microcirculation with local heat. 26th Annual Meeting Texas Chapter American College of Sports Medicine, Dallas, TX, 2005.

64. Desai KV, Cunningham CE, Stewart RH, Quick CM. Developing a novel animal model to study angiogenesis and angioadaptation. TAMU Student Research Week 2005.

65. Semien CP, Goudeau CA, Dongaonkar JR, Bogenschutz R, Stewart RH, Quick CM. Venomotion: do venules pump blood? Prairie View A&M University Biology Symposium, November 3 Proceedings, 16, 2006.

66. Kotiya A, Quick C, Stewart R, Laine G, Criscione J. On passive multiaxial mechanical response of lymphatic vessels. Experimental Biology meeting abstracts [on CD-ROM]. FASEB J 20, Abstract #245.7, 2006.

67. Ngo B, Quick CM, Stewart RH. Stimulation of the lymphatic pump inhibits passive flow. Experimental Biology meeting abstracts [on CD-ROM]. FASEB J 20, Abstract #488.2, 2006.

68. Wilson E, Stewart R, Patterson J, Auckland L, Bray J, Criscione J, Stallone J, Quick C,


Hardy J, Gashev A, Laine G, Zawieja D. Microarray analysis of molecular adaptation of lymphatic vessels to high flow conditions. Experimental Biology meeting abstracts [on CD-ROM]. FASEB J 20, Abstract #204.5, 2006.

69. Venugopal AM, Vasquez MC, Lee JC, Stewart RH, Quick CM. Increases in filling pressure and afterload results in lymphangion pump failure. 23rd Annual Houston Conference in Biomedical Research, February 9-10. HSEMB 23: 106, 2006.

70. Gatson SN, Stewart RH, Laine GA, Quick CM. Optimizing efficiency of undergraduate research experiences with Research-Intensive Communities. 2006 Annual Fall meeting of the Biomedical Engineering Society, Chicago, IL, October 11-14, Proceedings, Abstract #907, 2006.

71. Radhakrishnan R, Villarubia L, Xue H, Laine GA, Stewart RH, Weisbrodt NW, Cox CS. Hypertonic saline and its effect on intestinal lymph flow in the setting of acute intestinal edema. Gastroenterology 132(4): A241-A242, 2007.

72. Moore-Olufemi SD, Xue H, Allen SJ, Oliver DH, Moore FA, Weisbrodt N, Stewart R, Laine G, Cox CS. Transcriptional analysis of gut edema in rat intestine following pretreatment with selective iNOS inhibitor L-NIL. J Surg Res 137(2): 283, 2007.

73. Dongaonkar RM, Quick CM, Stewart RH, Laine GA. Edemagenic gain: interstitial fluid balance as feedback system. Proceedings of HSEMB 129; 2007.

74. Venugopal AM, Boyle RR, Warner J, Hanney JS, Stewart RH, Quick CM. Mechanical summation of lymphatic contractions in batwing microcirculation. Proceedings of HSEMB 63; 2007.

75. Widmer RJ, Stewart RH, Young MF, Laurinec JE, Laine GA, Quick CM. Capillary recruitment accompanies the biphasic flow response to local heat in a thermoregulatory microvascular network. FASEB J 21: A1313, 2007.

76. Dongaonkar RM, Quick CM, Stewart RH, Laine GA. Edemagenic gain and interstitial fluid regulation. FASEB J 21: A488, 2007.

77. Dongaonkar RM, Meisner JK, Quick CM, Stewart RH. Bat wing venules pump blood. FASEB J 21: A483, 2007.

78. Venugopal AM, Quick CM, Laine GA, Stewart RH. Transmural flow modulates the lymphatic myogenic response in bovine mesenteric lymphatic vessels. FASEB J 21: A493-A494, 2007.

79. Wilson E, Laine G, Stewart RH. Functional and molecular adaptation of lymphatic vessels. FASEB J 22: 392.2, 2008.

80. Quick CM, Stewart RH, Venugopal AM, Dongaonkar RM, Moore JE, Laine GA. Multiscale modeling of the lymphatic system relates lymphangion properties to edema formation and resolution. FASEB J 23: 764.10, 2009.

81. Gatson SN, Scott M, Stewart R, Laine GA, Quick CM. A case for centralizing summer research programs: the DeBakey research-intensive community. FASEB J 23: 633.8, 2009.

82. Dongaonkar RM, Laine GA, Stewart RH, Quick CM. Integrating microvascular and lymphatic function with a balance point characterization of interstitial fluid and protein regulation. FASEB J 23:951.6, 2009.

83. Shah SK, Fogle LN, Aroom KR, Gill BS, Uray KS, Laine GA, Stewart RH, Cox CS. Mechanotransduction as a mechanistic explanation for edema induced intestinal dysfunction. J Am Coll Surg 209(3):S43, 2009.

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. 84. Dongaonkar RM, Laine GA, Stewart RH, Quick CM. Estimation of the microvascular

filtration coefficient from gravimetric data without neglecting interstitial fluid storage and lymphatic drainage. Frontiers in Microcirculation: Control Processes and Clinical Applications, Columbia, MO, October 16-17, 2009.

85. Shah SK, Uray KS, Xue H, Velez N, Moore-Olufemi SD, Kots AY, Choi BK, Stewart RH, Laine GA, Cox CS Jr. Signal transduction cascades initiated by intestinal edema: the iNOS/NO pathway. The 5th Annual Academic Surgical Congress, San Antonio, TX. February 3-5, 2010. Journal of Surgical Research 2010; 158(2): 295. PMID 20106012

86. Shah SK, Jimenez F, Walker PA, Xue H, Aroom KR, Norbury KC, Stewart RH, Laine GA, Cox CS Jr. Peritoneal fluid induces priming of naïve neutrophils in an animal model of abdominal compartment syndrome. The 5th Annual Academic Surgical Congress, San Antonio, TX. February 3-5, 2010. Journal of Surgical Research 2010; 158(2): 293. PMID 20106007 Judged best abstract for South Texas region

87. Shah SK, Jimenez F, Walker PA, Xue H, Uray KS, Aroom KR, Fischer UM, Norbury KC, Stewart RH, Laine GA, Cox CS Jr. A novel physiologic model for the study of abdominal compartment syndrome (ACS). The 5th Annual Academic Surgical Congress, San Antonio, TX. February 3-5, 2010. Journal of Surgical Research 2010; 158(2): 423. PMID 20106337

88. Nguyen T, Laine G, Stewart R, Quick C. Simple passive device to ensure isotonic contraction of intact tubular organs. FASEB J 24: 972.7, 2010.

89. Shah SK, Moore-Olufemi SD, Uray KS, Jimenez F, Walker PA, Xue H, Stewart RH, Laine, GA, Cox CS Jr. A novel murine model for the study of edema-induced intestinal contractile dysfunction. 2010 Joint International Meeting in Neurogastroenterology and Motility, Boston, MA. August 26-29, 2010.

90. Dongaonkar RM, Quick CM, Stewart RH, Laine GA. Evaluation of gravimetric techniques to estimate the microvascular filtration coefficient. FASEB J 24:972.6, 2010.

91. Dongaonkar R, Quick C, Stewart R, Laine G. Validation of conventional techniques to estimate the microvascular filtration coefficient. 9th World Congress for Microcirculation, 2010, Paris, France, September 6-9, 2010.

92. Shah SK, Jimenez F, Walker PA, Xue H, Feeley TD, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS Jr. Peritoneal fluid as a novel mechanism for neutrophil priming in a clinically relevant model of intra-abdominal sepsis. Journal of the American College of Surgeons 211(3):S43, 2010.

93. Shah S, Jimenez F, Walker P, Xue H, Uray K, Norbury K, Stewart R, Laine G, Cox C Jr. Evaluating the effects of immediate application of negative pressure therapy after decompression from abdominal compartment syndrome: a pre-clinical study. 40th Critical Care Congress, Society of Critical Care Medicine, San Diego, CA. January 15-19, 2011.

94. Shah S, Jimenez F, Walker P, Xue H, Uray K, Norbury K, Stewart R, Laine G, Cox C Jr. Effect of early negative pressure therapy (NPT) on pro-inflammatory characteristics of peritoneal fluid (PF) and plasma in abdominal compartment syndrome (ACS). 40th Critical Care Congress, Society of Critical Care Medicine, San Diego, CA. January 15-19, 2011.

95. Nguyen TL, Dongaonkar RM, Laine GA, Hardy J, Quick CM, Stewart RH, Wilson


E. Short-term functional adaptation of bovine mesenteric lymphatic vessels to altered transmural pressure and flow. FASEB J 25:632.3, 2011.

96. Dongaonkar RM, Vo JC, Quick CM, Stewart RH, Laine GA. Continuous interstitial fluid pressure-volume (compliance) measurement. FASEB J 25:634.1, 2011.

97. Dongaonkar RM, Laine GA, Stewart RH, Quick CM. Balance point approach to characterize regulation of microvascular, lymphatic, and interstitial pressures. Annual Fall Meeting of the Biomedical Engineering Society, Hartford, CT, October 13-15, 2011.

98. Dongaonkar RM, Quick CM, Stewart RH, Laine GA. Re-evaluating the interstitial fluid pressure-volume (compliance) relationship. FASEB J 26:854.2, 2012.

99. Nguyen TL, Dongaonkar RM, Hardy J, Laine GA, Quick CM, Stewart RH. Sustained high luminal flow in vivo decreases maximal developed tension of bovine mesenteric lymphatic vessels. FASEB J 26:677.3, 2012.

100. Sprake P, Roussel AJ, Nabity M, Stewart R, Bissett WT. The effect of ammonium chloride treatment as a long term preventative approach for urolithiasis in goats and a comparison of continuous and pulse dosing regimens. 2012 ACVIM Forum Proceedings, June 2012

101. Nguyen TL, Dongaonkar RM, Stewart RH, Laine GA, Quick CM. Prediction of the behavior of a lymphatic network emerging from complex interactions of lymphangions. BMES Annual Meeting, October 24-27, 2012.

102. Dongaonkar RM, Nguyen TL, Stewart RH, Laine GA, Quick CM. Differential sensitivity of the lymphatic system to changes in capillary and central venous pressures prevents edema. BMES Annual Meeting, October 24-27, 2012.

103. Dongaonkar RM, Nguyen TL, Quick CM, Laine GA, Wilson E, Heaps C, Hardy J, Stewart RH. Post-nodal lymphatic vessels adapt to sustained high flow conditions by becoming weaker pumps. FASEB J 27:902.5, 2013.

104. Wilkerson A, Mason C, Wilder W, Quick CM, Stewart RH. Mechanical determinants of ejection fraction and the relation to efficiency. Texas A&M University Student Research Week, March 24, 2014.

105. Nwokocha C, Schueler J, Villareal M, Duong T, Westra D, Quick CM, Stewart RH. Cardiac adaptation to wall stress. Texas A&M University Student Research Week, March 24, 2014.

106. Ahmed H, Hise F, Chikhliya U, Albaba E, Quick CM, Stewart RH. Adaptation to endothelial shear stress predicts both patency and regression of the ductus arteriosus. Texas A&M University Student Research Week, March 24, 2014.

107. Nwokocha CA, Schueler JD, Villarreal MR, Westra DJ, Duong TW, Quick CM, Stewart RH. Integrating biomechanics and mechanobiology to predict cardiac contractility in a closed-loop system. BMES Annual Meeting, October 22-25, 2014.

108. Mason C, Wilder W, Wilkerson A, Garcia A, Mohiuddin MW, Stewart RH, Quick CM. Novel approach to optimize both simplicity and accuracy when simplifying complex algebraic models. BMES Annual Meeting, October 22-25, 2014.

109. Ahmed H, Hise F, Chikhliya U, Quick CM, Stewart RH. Cardiovascular mechanical properties affect regression of the ductus arteriosus. BMES Annual Meeting, October 22-25, 2014.

110. Dongaonkar RD, Stewart RH, Quick CM. Research-intensive community to create a


large-scale, low-cost undergraduate research program. BMES Annual Meeting, October 22-25, 2014.

111. Washburn S, Posey D, Stewart R, Rogers K. Case study project in physiology enhances student engagement and communication skills, CVMBS Teaching Showcase, January 7, 2015.

Research Presentations without Published Abstracts 1. Stewart RH, Zawieja DC, Quick CM. The dual role of lymphatic vessels as pumps and

conduits. Gordon Research Conference, Ventura, CA, March 7-12, 2004. Book Chapters 1. Stewart RH and Rush-Moore B. Cervical vertebral stenotic myelopathy. In Reed SM

and Bayly WM, eds.: Equine Internal Medicine, Philadelphia, WB Saunders 1997, pp. 479-483.

2. Stewart RH. Considerations in fluid and electrolyte therapy. In Reed SM and Bayly WM, eds.: Equine Internal Medicine, Philadelphia, WB Saunders, 1997, pp. 192-198.

3. Stewart RH and Rush BR. Cervical vertebral stenotic myelopathy. In Reed SM, Bayly WM and Sellon DC, eds.: Equine Internal Medicine, 2nd Edition, Philadelphia, WB Saunders, 2004, pp. 594-599.

4. Stewart RH. Interstitial edema. In Silverstein D and Hopper K, eds.: Small Animal Critical Care Medicine, 2nd Edition, St. Louis, Saunders/Elsevier, 2014, pp. 60-63

Non-Refereed Publications 1. Stewart RH. Central nervous system trauma. Vet Clin NA: Eq Pract 3(2): 371-377,

1987. PMID: 3497697 2. Stewart RH and Griffiths JP. Medical management of spinal cord disease. Vet Clin

NA: Eq Pract 3(2): 429-436, 1987. PMID: 3113696 Invited Presentations 1. Frequency and severity of osteochondrosis in cervical stenotic myelopathy in

horses. 8th ACVIM Forum, Washington D.C., May 1990. 2. Non-traditional acid-base physiology. Medical Forum, Dept. Large Animal Medicine

& Surgery, Texas A&M University, College Station, TX, October 1991. 3. Pathophysiology of pulmonary edema. 11th ACVIM Forum, Washington D.C., May

1993. 4. Pathophysiology of myocardial edema. 13th ACVIM Forum, Orlando, FL, May 1995. 5. Fluid balance in hypoproteinemic patients. 14th ACVIM Forum, San Antonio, TX,

May 1996. 6. Myocardial edema and pericardial effusion. 15th ACVIM Forum, Lake Buena Vista,

FL, May 1997. 7. Pathophysiology of synovial effusions. 17th ACVIM Forum, Chicago, IL, June 1999.

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. 8. The fundamentals of interstitial fluid balance. 8th International Veterinary Emergency

& Critical Care Symposium. San Antonio, TX, September 2002. 9. The pathophysiology of edema formation. 8th International Veterinary Emergency &

Critical Care Symposium. San Antonio, TX, September 2002. 10. Non-traditional acid-base physiology. Emergency Medicine Rounds, Dept. Small

Animal Medicine & Surgery, Texas A&M University, College Station, TX, February, 2003

11. The ins and outs of interstitial edema formation: Part I. 9th International Veterinary Emergency & Critical Care Symposium. New Orleans, LA, September 2003.

12. The ins and outs of interstitial edema formation: Part II. 9th International Veterinary Emergency & Critical Care Symposium. New Orleans, LA, September 2003.

13. Treatment of edema using the lymphatic system. 9th International Veterinary Emergency & Critical Care Symposium. New Orleans, LA, September 2003.

14. Fluid therapy and edema: How much is too much? 9th International Veterinary Emergency & Critical Care Symposium. New Orleans, LA, September 2003.

15. Non-traditional acid-base physiology. Emergency Medicine Rounds, Dept. Small Animal Medicine & Surgery, Texas A&M University, College Station, TX, February, 2004


17. Inflammatory edema: It’s not what we thought. 23rd ACVIM Forum, Baltimore, MD, June 2005.


19. More information you can get from your blood gas results: Part 1. 12th International Veterinary Emergency & Critical Care Symposium. San Antonio, TX, September 2006.

20. More information you can get from your blood gas results: Part 2. 12th International Veterinary Emergency & Critical Care Symposium. San Antonio, TX, September 2006.

21. MOF: A closer look at the gastrointestinal tract. 12th International Veterinary Emergency & Critical Care Symposium. San Antonio, TX, September 2006.

22. Edema formation and inflammation: New information. 12th International Veterinary Emergency & Critical Care Symposium. San Antonio, TX, September 2006.


24. Lymphatic pump-conduit behavior. 3rd Annual CVRI Research Retreat. Temple, TX October 2007.

25. Analytical solutions for interstitial fluid balance. Dept. Systems Biology & Translational Medicine Seminar, Texas A&M Health Science Center, College Station, TX, March 4, 2009.

26. Intestinal edema: Causes and consequences. 15th International Veterinary


Emergency & Critical Care Symposium. Chicago, IL, September 2009. 27. Intestinal edema: Treatment with hypertonic saline. 15th International Veterinary

Emergency & Critical Care Symposium. Chicago, IL, September 2009. 28. Edema and intravenous fluid therapy. 15th International Veterinary Emergency &

Critical Care Symposium. Chicago, IL, September 2009. 29. Non-respiratory acid-base: Roles of the gut and kidney. 15th International Veterinary

Emergency & Critical Care Symposium. Chicago, IL, September 2009. SERVICE ACTIVITIES Professional Organizations Diplomate, American College of Veterinary Internal Medicine Member, American Physiological Society Member, Microcirculatory Society Member, American Veterinary Medical Association Manuscript Review for Journals (ad hoc) American Journal of Physiology: Heart and Circulatory Physiology American Journal of Physiology: Regulatory, Integrative and Comparative Physiology Microvascular Research British Journal of Pharmacology Journal of Veterinary Internal Medicine American Journal of Veterinary Research Lymphatic Research & Biology Major Committee Assignments The Ohio State University Veterinary Teaching Hospital Hospital executive committee, Clinical resident liaison. 1987-1989 Texas A&M University Department of Veterinary Physiology & Pharmacology Faculty search committees Position in bioengineering, 2001-02 Hire: Christopher Quick Positions (2) in cardiovascular science, 2004-06 Hire: Cristine Heaps Hire: Cuihua Zhang Positions in pharmacology, 2004-05 Hire: Maya Scott Hire: Virginia Fajt

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. Position in cardiovascular pharmacology, 2006-07; Committee chair Search closed without hire Position in cardiovascular physiology, 2008; Committee chair Hire: Guichun Han Position in physiology instruction, 2011-2012; Committee chair Hire: Juan Carlos Robles Position in pharmacology instruction, 2013-present; Committee chair Position in physiology research, 2014-present Hire: Ranjeet Dongaonkar VTPP promotion & tenure committee, 2013-present College of Veterinary Medicine and Biomedical Sciences Scholarship and awards committee, 2001-2005 Student-faculty relations committee/Honor council, 2002-06 Committee chair, 2004-06 Faculty advisor to: Veterinary class of 2005 First-year veterinary student mentor program, 2001-06; 2012-present Faculty search committees Positions in Large Animal Clinical Sciences for emergency/critical care, 2002 Hire: Joanne Hardy Hire: Peggy Marsh Position in Small Animal Clinical Sciences for cardiology, 2004-05 Hire: Ashley Saunders Position in Small Animal Clinical Sciences for emergency/critical care, 2003-05 Hire: Jennifer O'Geer-Gyles Positions in Small Animal Clinical Sciences for anesthesia, 2003-06 Hire: Alonso G. Guedes Hire: Mauricio A. Lépiz Position in Small Animal Clinical Sciences for cardiology, 2014-present Peer teaching review committees: Review for Clinical Associate Professor promotion, VPAT, 2007 Review for Clinical Associate Professor promotion, VPAT, 2007 Non-thesis masters task force, 2011-2012 Biomedical Science Program non-thesis masters advisory committee, 2012-2014 Strategic planning retreat, 2012 Curriculum committee, 2012-present Academic progress committee I - Fall, 2012-present Academic progress committee I - Spring, 2012-present College promotion & tenure committee, 2013-present Assoc. Former Students Achievement Awards selection committee (college), 2014 Lechner Scholarship review committee, 2014 Assoc. Former Students Achievement Awards selection committee (college), 2015

Curriculum Vitae Randolph H. Stewart, DVM, Ph.D. University Link Equine Research Endowment Member, Scientific advisory committee, 2003-present Director, 2015-present Assoc. Former Students Achievement Awards selection committee (university), 2014 Educating Leaders Grand Challenge, 2014 The focus of the Educating Leaders Grand Challenge is to reduce STEM

achievement disparities and promote academic excellence in P-20 education through integrative research, innovative technologies, and evidence-based practices.

Faculty Senate Senator, 2015-present Professional American College of Veterinary Internal Medicine Internal medicine specialty examination committee, 1993-1997 American Heart Association Western Review Consortium, grant reviewer, 2006-2007 South Central Affiliate, grant reviewer, 2007-2009 Florida Department of Health James and Esther King Biomed. Research Program, grant reviewer, 2007-2009 Bankhead-Coley Cancer Research Program, grant reviewer, 2007-present Cardiovascular Research Institute, Texas A&M Health Science Center 3rd CVRI Research Symposium, October 2007 Planning committee, Session chair, Presentation judge 4th CVRI Research Symposium, May 2013 Planning committee Broad Medical Research Program, grant reviewer ad hoc, 2006-2013 International Programs Borlaug Institute/USDA Faculty Exchange Program with Iraq Mentor for visiting Iraqi veterinarian Dr. Isam Mohammed Jaber Kadim (Zabiba), Fall 2012 Study abroad: University of Glasgow, Glasgow, Scotland, 2014 Collaborated with colleagues at the University of Glasgow to initiate establishment of

a study abroad opportunity for Texas A&M undergraduates to study physiology and cardiovascular modeling in Scotland.

CURRICULUM VITAE Randolph H. Stewart, DVM, Ph.D. · CURRICULUM VITAE. Randolph H. Stewart, DVM,...

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