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CURRICULUM VITAE

MARION K. GORDON, Ph.D. Date: June 18, 2009 Title: Associate Professor Address: Department of Pharmacology and Toxicology Ernest Mario School of Pharmacy, Rutgers University 170 Frelinghuysen Road Piscataway, NJ 08854 Correspondence: Home phone (609) 750-9414 Work phone (732) 445-3751 FAX: (732) 445-0119 e-mail magordon@eohsi.rutgers.edu EDUCATION 1973 B.A. Chemistry & French, Douglass College, New Brunswick, NJ (Worked as a chemist for several years before entering graduate school.) 1986 Ph.D. Biochemistry, University of Medicine and Dentistry of N.J. jointly with Rutgers

University, Piscataway, NJ POSTDOCTORAL TRAINING 1986-1987 Postdoctoral fellow, Department of Anatomy and Cellular Biology, Harvard

Medical School, Boston, MA 1987-1991 Postdoctoral fellow, Department of Anatomy and Cellular Biology, Tufts

University School of Medicine, Boston, MA ACADEMIC APPOINTMENTS 1991-1992 Research Scientist, Department of Anatomy and Cellular Biology, Tufts

University School of Medicine, Boston, MA

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1992-1997 Research Assistant Professor, Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA

1997-1998 Assistant Professor (tenure track), Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA

1992-1999 Member, Graduate Program in Cell, Molecular and Developmental Biology, Sackler School of Biomedical Sciences, Tufts University, Boston, MA 1997-1998 Secondary Appointment, Ophthalmology, New England Medical Center, Boston,

MA 1998-2000 Adjunct Research Assistant Professor, Department of Anatomy and Cellular Biology, Tufts University, Boston, MA 1998-2002 Research Assistant Professor, Department of Pharmacology and Toxicology Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 1999- Member, Environmental and Occupational Health Sciences Institute, Piscataway,

NJ 1999- Member, Faculty of the Graduate School, New Brunswick, NJ 1999- Member, Graduate Program in Toxicology, Rutgers University, Piscataway, NJ 1999- Member, Graduate Program, Cell & Developmental Biology, Piscataway, NJ 1999- Member, Graduate Program in Biochemistry, Rutgers University, Piscataway, NJ July, 2002- Research Associate Professor, Department of Pharmacology and Toxicology Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 2002- Member, Cancer Institute of New Jersey, New Brunswick, NJ July, 2006 Associate Professor, tenure track, Department of Pharmacology and Toxicology,

Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ July, 2007- Associate Professor with tenure, Department of Pharmacology and Toxicology,

Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ AWARDS AND HONORS 1988-1991 Individual National Research Service Award: "Avian Cornea Developmental Regulation of Collagens." 1995 Invited to the laboratory of Dr. Ulla Wewer for a 1 month collaborative research

project, Department of Pathological Anatomy, University of Copenhagen, Denmark

1997 International Outside Examiner of Ph.D. thesis for Paivi Hagg, Department of Medical Biochemistry, University of Oulu, Oulu, Finland

2000 Young Faculty Participation Award from the American Association of Anatomists

2000- Lecturer in the National Eye Institute sponsored course “Fundamental Issues in Vision Research,” Marine Biological Laboratories, Woodshole, MA.

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Topic: “Corneal Extracellular Matrix” (given every other year in even years) 2000-2007 Named co-director of the Signal Transduction Core of the NIEHS Center for

Excellence at the Environmental and Occupational Health Sciences Institute, Piscataway, NJ (jointly administered by Rutgers University and UMDNJ, Robert Wood Johnson Medical School)

2002 Program organizer for the “Matrix and Morphogenesis” conference, held April 13, 2002 at the Park Plaza Hotel, Boston, MA

2004 appointed to the Editorial Board of Developmental Dynamics 2004 appointed to the Board of Reviewers for Anatomical Record 2004-2008 Elected to an executive position in a national society: Co-chair of the Program Committee for the American Association of Anatomists, which is a

core member society of FASEB (Federation of American Societies for Experimental Biology) 2007- Invited by the Douglass Residence Campus Dean Carmen Twillie Ambar to be on

the Faculty Advisory Committee for the Douglass Project for Rutgers Women in Math, Science and Engineering

2007- Member of Advisory Cabinet for the Fundamentals in Vision Research course, taught at the MBL in Woods Hole, MA—The National Eye Institute has direct input into course topics, has a representative present during the course, and sponsors the course.

2007- Faculty advisor for Pharmacy Profession Fraternity, Alpha Zeta Omega 2008, Apr 6 Moderator for the American Association of Anatomists annual meeting Keynote

Address by Harold f. Dvorak, MD, entitled “Angiogenesis: the Importance of Anatomy,” Experimental Biology 2008 meeting, San Diego, CA.

2008, Apr 6 Symposium chair for “Deciphering the Actions of Angiogenesis Inhibitors: Surprises and New Directions,” American Association of Anatomists, Experimental Biology 2008 meeting, San Diego, CA.

2008, Jun 6 Moderator for the 36th Annual Scientific Session of the New Jersey Thoracic Society meeting

2008 Special Guest Editor for Developmental Dynamics volume 237, issue 10 (Oct.) Special issue entitled: Special Focus on the Extracellular Matrix, in Memory of

Dr. Elizabeth D. Hay 2009, May 5 Moderator for the symposium entitled “Corneal Wound Healing and Cell

Biology” at the annual Association for Research in Vision and Ophthalmology (ARVO) meeting

MEDICAL SCHOOL AND UNIVERSITY COMMITTEE ASSIGNMENTS 1995-1996 Chair, Secondary Appointments Committee, Department of Anatomy and

Cellular Biology, Tufts University School of Medicine 1996- 1998 Graduate Advisory Committee, Graduate Program in Cell, Molecular and

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Developmental Biology, Tufts University 1997- 1998 Admissions Committee, Cell, Molecular and Developmental Biology Graduate Program, Tufts University 1999- 2000 Library Committee, Rutgers College of Pharmacy 2000 Rutgers College of Pharmacy Self-Study Subcommittee on Students for the

American Council of Pharmaceutical Education 2000- 2001 Curriculum Committee, Rutgers College of Pharmacy 2001- 2003 Toxicology division representative to the EOHSI seminar committee 2002- 2003 Ernest Mario School of Pharmacy Scholastic Standing Committee 2002 Member of organizing committee for the Fifth Annual Women in Science Symposium: “Environmental Justice and Community Health Issues” 2003 Rutgers University and UMDNJ Focus Group on library collections, services,

and facilities needed by faculty and students on the New Brunswick/Piscataway campuses.

2003- Toxicology Graduate Program (Rutgers University and UMDNJ) Admission Committee

2003- Curriculum Committee, Ernest Mario School of Pharmacy 2005-2006 Ernest Mario School of Pharmacy Admissions and Recruitment Committee 2005-2006 Self-Study Focus Group to evaluate the Ernest Mario School of Pharmacy

Curriculum for the Accreditation Council for Pharmacy Education 2007- Faculty Advisory Committee, Douglass Project for Rutgers Women in Math, Science and Engineering. THESIS COMMITTEE SERVICE Member D.M.D. thesis committee for Howard Park, (degree received 1992),"Type X

collagen expression in developing rat condyle", Advisor: Dr. Ichiro Nishimura, Harvard Medical School/Harvard School of Dental Medicine School, Boston, MA.

Member M.M.Sc. thesis committee for Nadeem Y. Karimbux, (degree received 1993), “Expression of periodontal ligament extracellular matrix genes during development and wound healing", Advisor: Dr. Ichiro Nishimura, Harvard Medical School/Harvard School of Dental Medicine, Boston, MA.

Member D.M.Sc. thesis committee for Kun Sung Chung, (degree received 1995), "Modulated expression of type X collagen in cranial facial cartilages with different developmental fates", Advisor: Dr. Ichiro Nishimura, Harvard Medical School/Harvard School of Dental Medicine, Boston, MA.

Member Ph.D. thesis committee for Mary DeSouza, (degree received 1995), "Steroid regulated oviduct proteins in early pregnancy", Advisor: Dr. Mary Murray, Cell,

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Molecular and Developmental Biology, Tufts University School of Medicine, Boston, MA.

Member D.M.Sc. thesis committee for Ann Kania, (degree received 1997) "Characterization of structural variability in the fibril associated region of rat type XII collagen", Advisor: Dr. Ichiro Nishimura, Harvard Medical School/Harvard School of Dental Medicine, Boston, MA.

Outside Ph.D. thesis for Paivi Hagg, Department of Medical Biochemistry, (degree Examiner received 1997) "The Type XV Collagen Gene Structure", Advisor: Dr. Taina Pihlajaniemi,

Chairman, Department of Medical Biochemistry University of Oulu, Oulu, Finland University of Oulu, Oulu, Finland.

Member Ph.D. thesis committee for Laurie Delmolino, (degree received 1998), "Heparin Regulated Genes in Vascular Smooth Muscle Cells," Advisor: Dr. John Castellot, Cell, Molecular and Developmental Biology, Tufts University School of Medicine, Boston, MA.

Member Ph.D. thesis committee for Monica Olague de Marchan, (degree received 2000) “Characterization of the Structural Alterations caused by a Disease-associated Mutation (G627V) in the BP180 Protein (Type XVII Collagen),” Advisor: Dr. George Giudice, Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Member Ph.D. thesis proposal committee for Lisa Morio, (degree received 2000) “Effects of chronic exposure to hepatotoxicants on liver and lung macrophages. Role of tumor necrosis factor-alpha and nitric oxide in hepatotoxicity,” Advisor: Dr. Debra Laskin, Joint Graduate Program in Toxicology, Rutgers University and UMDNJ, Piscataway NJ.

Member Ph.D. thesis committee for Blanche Young, (degree received 2001) “Collagen XIV controls tendon fibril diameter during development,” Advisor: Dr. David Birk, Cell, Molecular and Developmental Biology, Tufts University School of Medicine, Boston, MA.

Member Ph.D. thesis committee for Nosheen Ahmad, (degree received 2001) “Mechanisms Regulating Macrophage Accumulation and Mediator Release in the Liver during Acute Endotoxemia,” Advisor: Advisor: Dr. Debra Laskin, Joint Graduate Program in Toxicology, Rutgers University and UMDNJ, Piscataway NJ.

Member Ph.D. thesis committee for Donna Dambach, (degree received 2001) “Regulation of Inflammatory Mediator Production during Acetaminophen-Induced Hepatotoxicity” Advisor: Advisor: Dr. Debra Laskin, Joint Graduate Program in Toxicology, Rutgers University and UMDNJ, Piscataway NJ.

Member Ph.D. thesis committee for Ladan Fakhrzadeh, (degree received 2002) “Mechanisms Regulating Macrophage Production of Inflammatory Mediators in the Lung following Ozone Inhalation,” Advisor: Dr. Debra Laskin, Toxicology Program Rutgers University, Piscataway NJ.

Member Ph.D. thesis committee for Brian Chiu, (degree received 2003) “Role of Antioxidants and Tumor Necrosis Factor in Acetaminophen-Induced Hepatotoxicity,” Advisor: Dr. Debra

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Laskin, Joint Graduate Program in Toxicology, Rutgers University and UMDNJ, Piscataway NJ.

External George H. Cook Scholar thesis, “Induction of the Cell Surface Protein Reviewer EMMPRIN by Benzo(a)pyrene in Melanoma Cells,” by Sharon L. Seelman (‘05); Lori A. White, project advisor. Member Oral Qualifying exam committee for Caren Villano, Joint Graduate Program in Toxicology,

Rutgers University, 2005. Member Oral Qualifying exam committee for Kyle Murphy, Molecular Biosciences Program,

Rutgers University, 2005. Member Ph.D. thesis committee for John Kozlosky, (degree expected 2008), “Inhibition of

angiogenesis by MTBE” Advisor: Dr. Keith Cooper, Joint Graduate Program in Environmental Sciences, Rutgers University and UMDNJ, Piscataway NJ.

Advisor Ph.D. candidate Ming-Wei Chao, Joint Graduate Program in Toxicology, Rutgers University and UMDNJ, Piscataway NJ. (degree expected 2009) “Effect of Diesel Particles on Cell-Cell Junctions of Capillary Endothelia.”

Advisor Ph.D. candidate Andrea DeSantis, Joint Graduate Program in Toxicology, Rutgers University and UMDNJ, Piscataway NJ. (degree expected 2012) “Countermeasures against Corneal Mustard Exposures.”

Member Ph.D. thesis committee for Yang Wang, (degree received 2007) “Hypoxia Inducible Factor-Targeted Anticancer Prodrugs” Advisor: Dr. Tamara Minko, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ.

Member Ph.D. thesis committee for Caren Villano, (degree received 2007) “The Inhibitor of DNA binding Proteins in Cellular Proliferation and Differentiation: Regulation by the Retinoic Acid Signaling pathway” Advisor: Dr. Lori White, Joint Graduate Program in Toxicology, Rutgers University and UMDNJ, Piscataway NJ.

Member Ph.D. thesis committee for Jedd Hilligas, (degree received 2007) “The Role of Matrix Metalloproteinases in Zebrafish (Danio rerio) Embryogenesis and Their Regulation by glucocorticoids”, Advisor: Dr. Lori White, Joint Graduate Program in Toxicology Rutgers University and UMDNJ, Piscataway NJ.

Advisor Masters and Ph.D. candidate Peiwen Po, Joint Graduate Program in Toxicology, UMDNJ & Rutgers University, Piscataway NJ. (degree expected 2013) “Evaluation of Tocopherols to Offset the Adverse Effects of Diesel Exhaust Particles on Cappillary Endothelial Cells”.

Outside Ph.D. thesis for Anne Tuomisto, Department of Medical Biochemistry, (degree Examiner expected 2009) Topic:Type XIII Collagen, Advisor: Dr. Taina Pihlajaniemi, Chairman,

Department of Medical Biochemistry University of Oulu, Oulu, Finland. TEACHING RESPONSIBILITIES 1977- 1980 Teaching assistant; Introductory Chemistry, Rutgers University

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1992-present Lecturer; Connective and Mineralized Tissues, Harvard Dental School (The course has had 3 course directors since 1992. Each has requested my participation with a collagen review lecture.)

1994 Facilitator; Journal Club, Graduate Program in Cell, Molecular and Developmental Biology, Tufts University 1995-1998 Lecturer; Histology, Tufts University School of Dentistry 1995-1998 Lecturer; Cell Biology, Tufts University School of Veterinary Medicine 1996 Facilitator; Journal Club, Graduate Program in Cell, Molecular, and Developmental Biology, Tufts University 1998-present Lecturer; Pharmacology I, Ernest Mario School of Pharmacy, Rutgers University 1998 Lecturer; Toxicology, Rutgers Graduate Program in Toxicology 1999-present Lecturer; Pathophysiology, Ernest Mario School of Pharmacy, Rutgers University 1999-present Lecturer; Pharmacology II, Ernest Mario School of Pharmacy, Rutgers University 2000 Lecturer; Molecular Toxicology, Ernest Mario School of Pharmacy, Rutgers University

2000 Graduate Biochemistry Seminar Series, Rutgers University, Molecular Biosciences Program

2000 Lecturer; Mammalian Physiology, Rutgers University, Biochemistry Program 2002-2004 Co-director of Pharmacology II course, Ernest Mario School of Pharmacy, Rutgers

University 2002-2004 Lecturer; Introduction to Pharmacology, Ernest Mario School of Pharmacy, Rutgers

University 2008 Director of Pharmacology II course, Ernest Mario School of Pharmacy, Rutgers

University 2008 Lecturer for MASTER CLASS: PHYSICAL THERAPY & FASCIA given as part of the

American Association of Anatomists educational program for Experimental Biology 2008 meeting. Topic: “Histology and Organization of the Fascia.”

PROFESSIONAL SOCIETIES Association for Research in Vision and Ophthalmology American Society for Matrix Biology American Association of Anatomists American Society for Biochemistry and Molecular Biology Society of Toxicology New Jersey Skin Club New Jersey Thoracic Society OFFICE AND COMMITTEE ASSIGNMENTS IN PROFESSIONAL SOCIETIES 1997 Symposium Co-chair; East Coast Connective Tissue Society; Matrix Gene Expression

During Development

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1999 Mini symposium chair; FASEB Experimental Biology ‘99; Animal Models and Disease 1999-2000 Program Committee for American Association of Anatomists for the FASEB

Experimental Biology 2000 (EB 2000) meeting 2000 Chair of AAA Symposium for FASEB, EB 2000: Misregulation of Basement

Membrane in Human Disease 2001 Chair of AAA Symposium for FASEB, EB 2001: Age Related Changes in Structure

and Function of Extracellular Matrix 2001-2002 Program Committee for American Association of Anatomists for the FASEB

Experimental Biology 2002 (EB 2002) meeting 2002 Chair of AAA Symposium for FASEB, EB 2002: Angiogenesis: Fragments of

Polypeptides Conferring Antiangiogenic Properties (Judah Folkman featured speaker) 2002-2003 Program Committee for American Association of Anatomists for the FASEB

Experimental Biology 2003 (EB 2003) meeting 2002-2003 Committee Member for the American Association of Anatomists 2008(goal: assess past

annual meetings to improve the future meeting, EB03) 2002-2003 Chair of the American Association of Anatomists “Young Anatomist's Publication

Award Committee” 2003-2004 Appointed interim Co-chair of the Program Committee for the annual meeting of the

American Association of Anatomists, which is concurrent with core FASEB (Federation of American Societies for Experimental Biology) societies

2003-2008 Member of Executive Board of the American Association of Anatomists 2004-2008 Elected Co-chair of the Program Committee for the annual meeting of the American

Association of Anatomists, which is concurrent with core FASEB (Federation of American Societies for Experimental Biology) societies

2003-2006 Member of the Experimental Biology Program Coordinating Committee 2003- Ex officio member of the Educational Affairs Committee for the annual American

Association of Anatomists meeting with FASEB 2003-2005 Chair, Research Meetings Outreach Grant review committee for American Association of

Anatomists 2004-2005 Member of the Federation of American Societies for Experimental Biology (FASEB)

Excellence in Science Award Committee 2005-2008 Member of the Finance Committee for the American Association of Anatomists 2008- Member of the American Association of Anatomists Fellows Selection Committee PEER REVIEW STUDY SECTION ASSIGNMENT 2001 Ad Hoc reviewer for the NIH VisA (AED) study section (RO1 applications) 2002 Ad Hoc reviewer for RO3 grants-CSR and NIH National Eye Institute 2002-2007 Reviewer of doctoral and postdoctoral fellowships awarded by “Fight For Sight” 2003-2005 Reviewer of Research Outreach Grants for the American Association of Anatomists 2005-present Reviewer of faculty Grants-in-Aid for “Fight for Sight” 2005 Ad Hoc reviewer for Arthritis Research Campaign Project Grants (United Kingdom) 2006-present Ad Hoc reviewer for the Scientific Council of the Association Francaise Contre les Myopathies Grant Applications (Paris, France) 2006 Ad Hoc reviewer for the New Jersey Agricultural experiment Station

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2006 Chair of the American Association of Anatomist Research Outreach Grant Review Committee

2007 Ad Hoc reviewer for the National Science Foundation (NSF) research grants 2008 Ad Hoc reviewer for the NIH VisA (AED) study section (RO1 and R21 applications) 2009-2013 Regular reviewer for the NIH VisA (AED) study section RESEARCH INTERESTS Contribution of collagens to corneal transparency Delayed and abnormal corneal wound healing caused by vesicant exposure (sulfur mustard,

nitrogen mustard and half mustard) and identification of effective therapeutics Regulation of corneal development and wound healing via expression of discrete sets of collagens; pathological assembly of collagen matrices in the cornea Fibril-Associated Collagens with Interrupted Triple helices (FACITs)-role in collagen fibril

assembly Pathological assembly of collagen (fibrosis) in liver, lung, umbilical arteries & fetal membranes Function of transmembranous collagens in development and wound healing The role of EMMPRIN and collagen XXIII in tumor progression and metastasis Impact of diesel particles on capillary endothelial cell biology EDITORIAL ACTIVITY Reviewer for Journal of Biological Chemistry Journal of Cell Biology The American Journal of Pathology Matrix Biology Investigative Ophthalmology and Visual Science Experimental Eye Research Molecular Vision Proceedings of the National Academy of Sciences, USA Journal of Investigative Dermatology Connective Tissue Research Cell and Tissue Research

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International Journal of Biochemistry and Cell Biology International Journal of Developmental Biology Developmental Dynamics Anatomical Record Journal of Histochemistry and Cytochemistry Protein Expression and Purification Molecular Biology and Evolution Molecular Cancer Research FEBS Letters Biomaterials Cutaneous and Ocular Toxicology 2004-present Editorial Board of Developmental Dynamics 2004-present Board of Reviewers for Anatomical Record RESEARCH FUNDING Current Extramural Grant Support NIH 4RO1 EY09056 12/1/2005-11/30/2010 (years 16-20) Expression of Specialized Collagens in Cornea Marion K. Gordon, P.I. Direct Costs for year 19 $285,000 [total year 19 award: $444,600] Total five year award: $2,223,000 NIH U54 AR055073 9/28/2006- 5/31/2011 UMDNJ/Rutgers University CounterACT Research Center of Excellence Jeffrey D. Laskin, administrative P.I.; Total costs for 5 years: $18,686,008 Marion K. Gordon, PI of research project 2

Transmembranous collagens and matrix metalloproteinases as targets for

countermeasures for vesicants in the cornea. Direct 3rd year costs for Project 2: $340,000 [total year 3 costs for Project 2: $530,400] Total costs for 5 years of Project 2: $2,733,120

AAA Outreach Meeting Grant to support postdoctoral fellow travel to the Gordon Research Conference on Collagens, July, 2009 (chair Leena Bruckner-Tuderman).

Notice of award: 11-25-2008 Total Funding: $3,000

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Past Extramural Grant Support from NIH NIH Individual National Research Service Award (NRSA) “Avian Cornea Developmental Regulation of Collagens”. Marion K. Gordon, P.I. Direct Costs: $68,249 3/1/88-2/28/91 NIH 1RO1 EY09056 (5/01/91 to 4/30/96) Regulation of Fibril-Associated Collagens in Cornea

Marion K. Gordon, P.I. Total Award for years 1-5: $ 885,992 NIH 2RO1 EY09056 (5/01/96 to 4/30/01) Regulation of Fibril-Associated Collagens in Cornea

Marion K. Gordon, P.I., Total Award for years 6-10: $1,255,802 NIH 3RO1 EY09056 (5/01/01 to 4/30/05) Expression of Specialized Collagens in Cornea (project name modified in 2001) Marion K. Gordon, P.I., Total Award for years 11-14: $1,404,000 NIH 3RO1 EY09056 supplement $39,000 for year 12 (5/01/02 to 4/30/03) NIH 3RO1 EY09056 supplement $39,000 for year 13 (5/01/03 to 4/30/04) NIH 3RO1 EY09056 supplement $39,000 for year 14 (5/01/04 to 4/30/05) NIH 3RO1 EY09056-15 supplement awaiting A1 reevaluation of 4RO1 EY09056 $132,000 direct costs 5/1/05-11/30/05 Year 15 total award: $205,920 NIH-awarded Conference Support NIH R13 CA94972 Matrix and Morphogenesis Conference Marion K. Gordon, P.I. Direct Costs: $8,000 4/01/02 to 3/31/03 Past Extramural Grant Support from other agencies American Lung Association of New Jersey Regulation of Vessel Remodeling in Pulmonary Hypertension

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Marion K. Gordon, P.I. Total Award (3 years) $156,000 7/1/01 to 6/30/04 New Jersey Commission on Cancer Research EMMPRIN, a Tumor Product Inducing Matrix Metalloproteinases Marion K. Gordon, P.I. Total Award (2 years) $85,800 7/1/00 to 6/30/02 Past Intramural Grant Support Effects of UVB Light on EMMPRIN Expression in Human Corneal Epithelial Cells

Exploratory Research Pilot Grant funded by the NIEHS Center Grant for Environmental Health Sciences (Center Grant ES05022-12, M.A. Gallo, P.I.)

Marion K. Gordon, Pilot P.I. Direct Costs: $15,000

7/9/99-3/31/00

Whole Eye Organ Culture to Study Type XIV Collagen in Corneal Epithelial Wound Healing Exploratory Research Pilot Grant funded by the NIEHS Center Grant for Environmental Health Sciences (Center Grant ES05022-13, M.A. Gallo, P.I.)

Marion K. Gordon, Pilot P.I. Direct Costs: $15,000 7/1/00-3/31/01 Misregulation of collagen fibril diameter control in pulmonary fibrosis induced by bleomycin Exploratory Research Pilot Grant funded by the NIEHS Center Grant for Environmental Health Sciences (Center Grant ES05022-15, M.A. Gallo, P.I.) Marion K. Gordon, Pilot P.I.

Direct Costs: $15,000 7/1/02-3/31/03 Effect of Diesel Particles on Vascular Endothelial Cells Exploratory Research Pilot Grant funded by the NIEHS Center Grant for Environmental Health Sciences (Center Grant ES05022-19, D. Cory-Schlecta, P.I.) Marion K. Gordon, Pilot P.I. Direct Costs: $10,000 7/1/06-3/31/07 Past Grant Support for Supervised Pharm. D. Honors Student

Rutgers Undergraduate Research Fellowship

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Extracellular Matrix Changes in Fetal Growth Restricted Umbilical Arteries Direct Costs: $1,500 (selected by Johnson and Johnson for corporate funding) 7/1/02-6/30/03 Awarded to C. Andrew Kistler, Pharm.D. Honors Student Advisor: Marion K. Gordon Rutgers Undergraduate Research Fellowship

Cervical Softening as a Function of Collagen Fibril Structure Direct Costs: $1,500 (selected by Johnson and Johnson for corporate funding)

7/1/03-6/30/04 Awarded to William Vincent, III, Pharm.D. Honors Student Advisor: Marion K. Gordon PUBLICATIONS Refereed papers 1. Ninomiya, Y., Gordon, M.K., van der Rest, M., Schmid, T., Linsenmayer, T. and Olsen, B.R.

The developmentally regulated type X collagen gene contains a long open reading frame without introns. J. Biol. Chem. 261:5041-5050, 1986.

2. Gordon, M.K., Gerecke, D.R. and Olsen, B.R. Type XII collagen: Distinct extracellular matrix component discovered by cDNA cloning. Proc. Natl. Acad. Sci. USA 84:6040-6044, 1987.

3. Dublet, B., Oh, S., Sugrue, S., Gordon, M.K., Gerecke, D.R., Olsen, B.R. and van der Rest, M. The structure of avian type XII collagen: � 1(XII) chains contain 190 kDa non-triple-helicalamino-terminal domains and form homotrimeric molecules. J. Biol. Chem. 264:13150-13156, 1989.

4. Sugrue, S.P., Gordon, M.K., Seyer, J., Dublet, B., van der Rest, M. and Olsen, B.R. Immunoidentification of type XII collagen in embryonic tissues. J. Cell Biol. 109:939-945, 1989.

5. Gordon, M.K., Gerecke, D.R., Nishimura, I., Ninomiya, Y. and Olsen, B.R. A new dimension in the extracellular matrix. Conn. Tiss. Res. 20:179-186, 1989.

6. Gordon, M.K., Gerecke, D.R., Dublet, B., van der Rest, M. and Olsen, B.R. Type XII collagen: A large multidomain molecule with partial homology to type IX collagen. J. Biol. Chem. 264:19772-19778, 1989.

7. Fitch, J.M., Gordon, M.K., Marchant, J., Gibney, E. and Linsenmayer, T.F. Avian epidermis expresses collagens types I and II, but not type IX in a restricted spatial pattern during feather morphogenesis. Ann. N.Y. Acad. Sci. 580:492-495, 1990.

8. Linsenmayer, T.F., Gibney, E., Gordon, M.K., Marchant, J.K., Hayashi, M. and Fitch, J.M. Extracellular matrices of the developing chick retina and cornea: Localization of mRNAs for

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collagen types II and IX by in situ hybridization. Invest. Ophthal. and Vis. Sci. 31:1271-1276, 1990.

9. Linsenmayer, T.F., Chen, Q.A., Gibney, E.P. Gordon, M.K., Marchant, J.K., Mayne, R. and Schmid, T.M. Collagen types IX and X in the developing chick tibiotarsus: Analysis of mRNAs and proteins. Develop. 111:191-196, 1991.

10. Marchant, J.K., Linsenmayer, T.F. and Gordon, M.K. cDNA analysis predicts a cornea-specific collagen. Proc. Natl. Acad. Sci. USA 88:1560-1564, 1991.

11. Gordon, M.K., Castagnola, P., Dublet, B., Linsenmayer, T.F., van der Rest, M., Mayne, R.and Olsen, B.R. Cloning of a cDNA for a new member of the class of fibril associated collagens with interrupted triple helices. Eur. J. Biochem. 201:333-338, 1991.

12. Castagnola, P., Tavella, S., Gerecke, D.R., Dublet, B., Gordon, M.K., Seyer, J., Cancedda,R., van der Rest, M. and Olsen, B.R. Tissue-specific expression of type XIV collagen: A member of the FACIT class of collagens. Eur. J. Cell Biol. 59: 340-347, 1992.

13. Yoshioka, H., Zhang, H., Ramirez, F., Mattei, M.-G., Moradi- Ameli, M., van der Rest, M. and Gordon, M.K. Synteny Between the loci for a novel FACIT-like collagen locus (D65228E) and alpha 1(IX) collagen (COL9A1) on 6q12-q14 in humans. Genomics 13:884-886, 1992.

14. Myers, J.C., Kivirikko, S., Gordon, M.K., Dion, A.S. and Pihlajaniemi, T. Identification of a previously unknown human collagen chain, alpha 1(XV), characterized by extensive interruptions in the triple-helical region. Proc. Natl. Acad. Sci. U.S.A. 89:10144-10248, 1992.

15. Linsenmayer, T.F., Gibney, E.P., Igoe, F., Gordon, M.K., Fitch, J.M., Fessler, L.I. and Birk, D. E. Type V collagen: Molecular structure and fibrillar organization of the alpha 1(V) chain amino-peptide, a putative regulator of corneal fibrillogenesis. J. Cell Biol. 121:1181-1189, 1993.

16. Gerecke, D.R., Foley, J.W., Castagnola, P., Gennari, M., Dublet, B., Cancedda, R., Linsenmayer, T.F., van der Rest, M., Olsen, B.R. and Gordon, M.K. Type XIV collagen is encoded by alternate transcripts with distinct 5' regions and is a multidomain protein with homologies to von Willebrand factor, fibronectin, and other matrix proteins. J. Biol Chem. 268:12177-12184, 1993.

17. Gordon, M.K., Foley, J.W., Birk, D.E., Fitch, J.M. and Linsenmayer, T.F. Type V collagen expression and Bowman's membrane: Quantitation of mRNA in corneal epithelium and stroma. J. Biol. Chem. 269:24959-24966, 1994.

18. Fitch, J.M., Gordon, M.K., Gibney, E. and Linsenmayer, T.F. Analysis of transcriptional isoforms of collagen types IX, II and I in the developing avian cornea by competitive polymerase chain reaction. Devel. Dynamics 202:42-53, 1995.

19. Gordon, M.K., Foley, J.W., Linsenmayer, T.F. and Fitch, J.M. Temporal expression of types XII and XIV collagen mRNA and protein during avian corneal development. Devel. Dynamics 206:49-58, 1996.

20. DeCastro, R., Zhang, Y., Guo, H., Kataoka, H., Gordon, M.K., Toole, B.P. and Biswas, C. Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer. J. Invest. Dermatol. 106:1260-1265, 1996.

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21. Linsenmayer, T.F., Igoe, F., Gibney, E., Gordon, M.K. and Birk, D.E. Positive regulation of corneal type V collagen mRNA: Analysis by chicken-human heterokaryon formation. Exp. Cell Res. 228:36-43, 1996.

22. Cai, C.X., Gibney, E.P., Gordon, M.K., Marchant, J.K., Doane, K.J., Birk, D.E. and Linsenmayer, T.F. Avian corneal galactosyltransferase: Isolation of a cDNA by subtractive hybridization and developmental regulation. Exp. Eye Res. 63:193-200, 1996.

23. Gordon, M.K. Fitch, J.M., Foley, J.W., Gerecke, D.R., Linsenmayer, C., Birk, D.E. and Linsenmayer, T.F. Type XVII collagen (BP180) in the developing avian cornea. Invest. Ophthal. and Vis. Sci. 38:153-166, 1997.

24. Guo, H., Zucker, S., Gordon, M.K., Toole, B.P. and Biswas, C. Stimulation of matrix metalloproteinase production by recombinant EMMPRIN from transfected CHO cells. J. Biol. Chem.272:24-27, 1997.

25. Guo, H., Majmudar, G., Jensen, T.C., Biswas, C., Toole, B.P. and Gordon, M.K. Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases. Gene 220:99-108, 1998.

26. Linsenmayer, T.F., Fitch, J.M., Gordon, M.K., Cai, C.X., Igoe, F., Marchant, J.K., Birk, D.E. Development and roles of collagenous matrices in the embryonic avian cornea. Prog. Retin. Eye Res. 17:231-265, 1998.

27. Gordon, M.K., Marchant, J.K., Foley, J.W., Igoe, F., Gibney, E.P., Nah, H.-D., Barembaum, M., Myers, J.C., Rodrigues, E., Dublet, B., van der Rest, M., Linsenmayer, T.F., Upholt, W.B. and Birk, D.E. The complete primary structure of the chicken alpha 1(V) collagen chain. Matrix Biology 18:481-486, 1999.

28. Young, B.B., Gordon, M.K. and Birk, D.E. Characterization of type XIV collagen in developing chicken tendons: expression is associated with assembly and growth of collagen fibrils. Dev. Dynamics 217:430-439, 2000.

29. Morio, L.A., Chiu, H. Sprowles, K.A., Zhou, P., Heck, D.E., Gordon, M.K. and Laskin, D.L. Distinct roles of tumor necrosis factor-� and nitric oxide in acute liver injury induced by carbon tetrachloride in mice. Toxicology and Applied Pharmacology 172:44-51, 2001.

30. Koch, M., Foley, J.E., Hahn, R.A., Zhou, P., Burgeson, R.E., Gerecke, D.R.and Gordon, M.K. � 1(XX) collagen: a new member of the FACIT subfamily of collagens. J. Biol. Chem. 276:23120-23126, 2001.

31. Gardner, C.R., Laskin, J.D., Dambach, D.M., Sacco, M., Durham, S.K., Bruno, M.K.,Cohen, S.D., Gordon, M.K., Gerecke, D.R., Zhou, P., and Laskin, D.L. Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10. Toxicol. Appl. Pharmacol. 184:27- 35, 2002.

32. Ahmad, N., Chen, L.C., Gordon, MA (sic), Laskin, J.D. and Laskin, D.L. Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia. J. Leukoc. Biol. 71:1005-1011, 2002.

33. Meirowitz, N.B., Smulian, J.C., Hahn, R.A., Zhou, P., Shen-Schwarz, S., Lambert, G.H., Gerecke, D.R. and Gordon, M.K. Collagen mRNA expression in the human amniochorion in premature rupture of membranes. Am. J. Obstet. Gynecol. 187:1679-85, 2002.

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34. Sunil VR, Connor AJ, Zhou P, Gordon MK, Laskin JD, Laskin DL. Activation of adherent vascular neutrophils in the lung during acute endotoxemia.. Respir. Res. 3:21 (10 pgs). Epub 2002.

35. Gardner, C.R., Laskin, J.D., Dambach, D.M., Chiu, H., Durham, S.K., Zhou, P., Bruno,M., Gerecke, D.R., Gordon, M.K., and Laskin, D.L., Exaggerated Hepatotoxicity of Acetominophen in Mice Lacking Tumor Necrosis Factor Receptor-1: Potential Role of Inflammatory Mediators. Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1: Potential role of inflammatory mediators. Toxicol. Appl. Pharmacol. 192:119-30, 2003.

36. Koch, M., Laub, F., Zhou, P., Hahn, R.A., Tanaka, S., Burgeson, R.E., Gerecke,

D.R.,Ramirez, F., and Gordon, M.K. Collagen XXIV, a vertebrate fibrillar collagen with structural features of invertebrate collagens: selective expression in developing cornea and bone. J. Biol. Chem. 278:43236-44, 2003.

37. Tzortzaki, E.G., Morio, L., Tischfield, J.A., Sahota, A., Gordon, M.K., and Gerecke, D.R. Expression of FACIT Collagens XII and XIV During Bleomycin-Induced Pulmonary Fibrosis in Mice. Anat. Rec. 275:1073-80, 2003.

38. Kinzler, W.L., Smulian, J.C., Kister., C.A., Hahn, R.A., Zhou, P., and Gordon, M.K. Extracellular matrix changes in the umbilical arteries of growth restricted fetuses. Am. J. Obstet. Gynecol. 192:1053-9, 2005.

39. Shakarjian, M.P., Bhatt, P., Gordon, M.K., Chang, Y.-C., Casbohm, S.L., Rudge, T.L., Kiser, R.C., Sabourin, C.L., Casillas, R.P., Ohman-Strickland, P., Riley, D.J., and Gerecke, D.R. Preferential Expression of Matrix Metalloproteinase-9 in Mouse Skin After Sulfur Mustard Exposure. J. Appl. Toxicol. 26:239-246, 2006.

40. Matsuo, N., Tanaka, S., Gordon, M.K., Koch, M., Yoshioka, H. and Ramirez, F. CREB/AP1Protein Complexes Regulate Transcription of the Bone-specific Collagen XXIV Gene (Col24a1) In Osteoblasts. J. Biol. Chem., 281:5445-5452, 2006.

41. Tzortzaki, E.G., Koutsopoulos, A.V., Dambaki, K.I., Lambiri, I., Plataki, M., Gordon, M.K., Gerecke, D.R. and Siafakas, N.M. Active remodeling in idiopathic interstitial pneumonias (IIPs):Evaluation of collagen types XII and XIV. J. Histochem. Cytochem. 54:693-700, 2006.

42. Koch, M., Kutsch, S, Bhatt, P., Zhou, P., Song, R., Reindes, E., Hahn, R.A., Burgeson,R.E., Gerecke, D.R., and Gordon, M.K. Expression of type XXIII collagen mRNA and

protein. J. Biol. Chem. 281:21546-57, 2006. 43. Veit, G., Zimina, E.P., Franzke, C.-W., Kutsch, S., Siebolds, U., Gordon, M.K., Bruckner-

Tuderman L., and Koch, M. Shedding of Collagen XXIII is Mediated by Furin and Depends on the Plasma Membrane Microenvironment. J. Biol. Chem. 282:27424-35, 2007.

44. Chen, L.C., Laskin, J.D., Gordon, M.K. and Laskin, D.L. Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Exp. Mol. Pathol. 84:145-55. 2008.

45. Matsuo N., Tanaka S., Yoshioka H., Koch M., Gordon M.K., Ramirez F. Collagen XXIV (Col24a1) gene expression is a specific marker of osteoblast differentiation and bone formation. Connect Tissue Res.49:68-75, 2008.

46. Gerecke, D. R., Chen, M., Isukapalli, S.S., Gordon, M.K., Chang, Y.-C., Tong, W.,

4

Androulakis, I.P., Georgopoulos, P.G. Differential Gene Expression Profiling of Mouse Skin after Sulfur Mustard Exposure: Extended Time Response and Inhibitor Effect. Toxicol. Appl. Pharmacol.234:156-165, 2009.

47. Chang, Y.C., Sabourin, C.L.K., Lu, S.E., Sasaki, T., Svoboda, K.H., Gordon, M.K., Riley, D.J., Casillas, R.P., and Gerecke, D.R. Upregulation of Gamma-2 Laminin-332 in the Mouse Ear Vesicant Wound Model. J. Biochem. Mol. Tox. 23:172-184, 2009.

48. Shakarjian, M.P., Heck, D.E., Gray, J.P., Sinko, P.J., Gordon, M.K., Casillas, R.P., Heindel, N.D., Gerecke, D.R., Laskin, D.L., and Laskin, J.D. Mechanisms Mediating the Vesicant Actions of Sulfur Mustard after Cutaneous Exposure (submitted to Tox. Sci.).

49. Chao, M.-W., Kozlosky, J., Po, I., Svoboda, K.K.H., Cooper, K. Laumbach R. and Gordon M.K. Vascular Endothelial Cell-Cadherin is Redistributed Away From the Plasma Membranes of Endothelial Tubes in Response to Diesel Exhaust Particles (submitted to J. Toxicol. Env. Health).

Book chapters and review articles published 1. Olsen, B.R., Ninomiya, Y., Lozano, G., Konomi, H., Gordon, M.K., Green, G., Parsons, J.,

Seyer, J., Thompson, H. and Vasios, G. Short chain collagen genes and their expression in cartilage. Ann. N.Y. Acad. Sci. 460:141-153, 1985.

2. Olsen, B.R., Gerecke, D., Gordon, M., Green, G., Kimura, T., Konomi, H., Muragaki, Y., Ninomiya, Y., Nishimura, I. and Sugrue, S. "A new dimension in the extracellular matrix" in Collagen: Biochemistry, Biotechnology, and Molecular Biology, Vol. IV, (M.E. Nimni and B. Olsen eds.) CRC Press, Boca Raton, FL pp 1-19, 1989.

3. Gordon, M.K., Gerecke, D.R., Nishimura, I., Ninomiya, Y. and Olsen, B.R. A new dimension in the extracellular matrix. Conn. Tiss. Res. 20:179-186, 1989.

4. Ninomiya, Y., Castagnola, P., Gerecke, D., Gordon, M., Jancenko, O., LuValle, P.,McCarthy, M., Muragaki, Y., Nishimura, I., Oh, S., Rosenblum, N., Sato, N., Sugrue, S., Taylor, R., Vasios, G., Yamaguchi, N. and Olsen, B.R. "The molecular biology of collagens with short triple-helical domains" in Extracellular Matrix Genes (L.J. Sandell & C.D. Boyd eds.) Academic Press, San Diego, CA pp 80-114, 1990.

5. Gordon, M.K., Gerecke, D.R., Dublet, B., van der Rest, M., Sugrue, S.P. and Olsen, B.R. The structure of type XII collagen. Ann. N.Y. Acad. Sci. 580:8-16, 1990.

6. Gordon, M.K. and Olsen, B.R. The contribution of collagenous proteins to tissue-specific matrix assemblies. Curr Opin Cell Biol. 2:833–838, 1990.

7. Gerecke, D.R., Gordon, M.K., Wagman, D.W., Champliaud, M.F. and Burgeson, R.E. "Hemidesmosomes, anchoring filaments, and anchoring fibrils: Components of a unique attachment complex" in Extracellular Matrix Assembly and Structure, (P.D. Yurchenco, D.E. Birk and R.E. Mecham, eds.) Academic Press, Orlando, FL pp 417-439, 1994.

8. Olsen, B.R., Winterhalter, K.H. and Gordon, M.K. FACIT Collagens and their Biological Roles. Trends in Glycosci.& Glycotechnol. 34: 115-127, 1995.

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9. Linsenmayer, T.F., Fitch, J.M., Gordon, M.K., Cai, C.X., Igoe, F., Marchant, J.K., Birk, D.E. Development and roles of collagenous matrices in the embryonic avian cornea. Prog. Retin. Eye Res. 17:231-265, 1998.

10. Gerecke, D.R., Sabourin, C.L.K., Chang, Y.C, Laskin, J.D., Gordon, M.K., and Casillas R.P. Gene Expression Profiles of Vesicant-induced Skin Injury. Proceedings of the

HFM. Symposium on Defense Against the Effects of Chemical Hazards: Toxicology, Diagnosis, and Medical Countermeasures, NATO Research and Technology Organization Scientific Publication HFM-149, RTO-MP-HFM-149 at www.rto.nato.int, ISBN 978-92-837-0086-9, Oct, 2007.

11. Svoboda, K.K.H., Fischman, D. and Gordon, M.K. The embryonic chick corneal epithelium: a model system for exploring cell-matrix interactions. Dev. Dynamics 237: 2667-2675, 2008.

12. Gordon, M.K., Enzenauer, R.W., and Babin, M.K. “Ocular Toxicity of Sulfur Mustard” in Handbook of the Toxicology of Chemical Warfare Agents (Gupta, RC, ed.), ISBN: 978-0-12-374484-5, Elsevier Academic Press, Burlington, MA pp575-594, 2009.

13. Gordon, M.K. and Hahn, R.A. “Collagens at a Glance” Cell and Tissue Research (in revision, 2009).

Abstracts Published since 1997 1. Foley, J.E., Koch, M., Gerecke, D.R., Fitch, J.M. and Gordon, M.K. An NC1 domain splicing

variant of type XII collagen isolated from a corneal cDNA library. Matrix Biol.16:126-127,1997.

2. Koch, M., Foley, J.E., Gordon, M.K., Gerecke, D.R. and Burgeson, R.E. Analysis of a new cDNA and the 3' end of the type XII collagen gene predicts that one of three alternative last exons are used in alpha 1(XII) collagen mRNAs. Matrix Biol. 16:127, 1997.

3. Gordon, M.K., Foley, J.E., Koch, M., Gerecke, D.R. and Fitch, J.M. Splicing variant of type XII collagen expressed in avian cornea. Invest. Ophthalmol. Vis. Sci. 38 Part 2:3189, 1997.

4. Gordon M.K., Foley, J.E. and Koch, M. Type XX collagen, a new member of the fibril-associated (FACIT) family of collagens. FASEB J. 13 Part 2 Suppl:A1119, 1999.

5. Gordon, M.K., Foley, J.E. and Foley, J.W. Translational control of type XIV collagen expression in avian cornea. Invest. Ophthalmol. Vis. Sci. 40:S180, 1999.

6. Gordon, M.K., Hahn, R., Zhou, P., Bhatt, P., Goyal, M., Sharma, L., Heck, D., Laskin, J.D., and Laskin, D.L., Chen, G., McHugh, N.A., Tozzi, C.A., Riley, D.J. and Gerecke, D.R. Expression of Type XII collagen and EMMPRIN in normal and hypoxic pulmonary arteries. Toxicol. Sci. Suppl. 54:210, A987, 2000.

7. Gerecke, D.R., Hahn, R., Zhang, P., Heck, D.E., Laskin, J.D., Laskin, D.L., Chen, G., McHugh, N.A., Tozzi, C.A., Riley, D.J., and Gordon, M.K. Changes in collagen XII expression in hypertensive and recovering pulmonary arteries. Am. J. Respir. Crit. Care Med. 161:A444, 2000.

8. Gordon, M.K., Hahn, R.A., Zhou, P., Goyal, M., Bhatt, P., Heck, D., Laskin, J.D., Laskin, D.L., McHugh, N.A., Chen, G., Tozzi, C.A., Riley, D.J. and Gerecke, D.R. Type XII collagen and EMMPRIN in hypertensive pulmonary arteries. FASEB J. 14:A556, 2000.

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9. Gordon, M.K., Gerecke, D.R., Hahn, R.A., Bhatt, P., Goyal, M. and Koch, M. Cloning of anew collagen, type XXIII, expressed in cornea. Invest. Ophthalmol. Vis. Sci. 41:S752, 2000.

10. Gordon, M.K., Hahn, R.A., Zhou, P., Goyal, M., Bhatt, P., Heck, D., Laskin, J.D., Laskin, D.L., McHugh, N.A., Chen, G., Tozzi, C.A., Riley, D.J. and Gerecke, D.R. The role of type XIV collagen in pulmonary hypertension. FASEB J. 15:A716, 2001.

11. Gordon, M.K., Hahn, R.A., Zhou, P., Gallo, M.A., Heck, D., Gerecke, D.R. and Laskin, J.D. Comparison of matrix and cyclooxygenase expression in cultured human corneal epithelial cells and epithelia of donor corneas. Invest. Ophthalmol. Vis. Sci. 42:S584, 2001.

12. Tozzi, C.A., Gerecke, D.R., Zhou, P., Chen, G., Hahn, R., Riley, D.J. and Gordon, M.K. Expression of Extracellular Matrix Metalloproteinase Inducer During Pulmonary Artery Remodeling. Resp. and Crit. Care Med. 163: A122, 2001.

13. Gordon, M.K., Hahn, R.A., Zhou, P., Bhatt, P., Song, R., Kistler, C.A., Gerecke, D.R. and Koch, M. Characterization of a potential new fibrillar collagen, type XXIV. FASEB J.16: A359, 2002.

14. Gordon, M.K, Hahn, R.A, Zhou, P, Kistler, C.A, Gerecke, D.R, and Koch, M. Structure of Collagen XXIV and its Expression in Cornea and Retina. ARVO Meeting Abstracts 43: 3207, 2002.

15. Smulian, J.C., Meirowitz, N.B., Hahn, R.A., Zhou, P., Shen-Schwarz, S., Lambert, G.H., Gerecke, D.R. and Gordon, M.K. Fibril associated collagens with interrupted triple helices (FACITs) and fibrillar collagens in premature rupture of the fetal membranes. J Soc Gynecol Investig 8: S209A, 2002.

16. Gordon, M.K., Tzortzaki, E., Hahn, R.A., Zhou, P., Liu, B. and Gerecke, D.R. Alterations in collagen fibril diameter and collagen XIV expression with progressing pulmonary fibrosis. FASEB J. 17: A353, 2003.

17. Gordon, M.K., Zhou, P., Hahn, R.A., Kistler, CA., Gerecke, D.R. and Laskin, J.D. Expression of Collagen IV Chain mRNAs by Immortalized Corneal Epithelial Cells. ARVO Meeting Abstracts 44: 1342, 2003.

18. Gerecke, D.R., Liu, B., Morio, L.A., Zhou, P., Hahn, R.A., Laskin, J.D., Laskin, D. L.,and Gordon, M.K. Induction of FACIT Collagens XII and XIV During Carbon Tetrachloride-induced Hepatic Fibrosis. The Toxicologist, 67:A199, 2003.

19. Gordon, M.K. Kistler, C.A. Zhou, P., Hahn, R.A., Gerecke, D.R., Kinzler, W. and Smulian, J.C. Fetal Growth Restriction Alters Umbilical Artery Collagen Fibril Architecture. FASEB Journal,19, A3913, 2004. [accessed at http://www.biosis-select.org/faseb/index.html].

20. Gordon, M.K., Hahn, R.A., Zhou, P., Olsen, B.R., Reichenberger, E. and Gerecke, D.R. Alterations in the corneal stroma of transgenic mice carrying a truncated collagen XII gene. ARVO Meeting Abstract (selected for oral presentation), May 2004.

21. Kinzler, W., Smulian, J., Kistler, C.A., Hahn, R.A, Zhou, P., Gordon M.K. Umbilical artery extracellular matrix remodeling in fetal growth restriction. Submitted to the Society of Maternal Fetal Medicine, Sept 2004.

22. Gerecke, D.R., Bhatt, P., Chang, Y.C., Sabourin, C.L., Rudge, T.L., Jr., Kiser, R.C., Casbohm, S.L., Gordon, M.K., Riley, D.J., Shakarjian, M., and Casillas, R.P. The Matrix Metalloproteinase Inhibitor GM1489 Reduces MMP-9 Activity after Sulfur Mustard Exposure in vivo. The Toxicologist, A780, Society of Toxicology Meeting Abstract, March 2005

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23. Gordon, M.K., Vincent, W.R., III, Hahn, R.A., Han, S., Zhou, P., Shen, J., Lambert, G.H.,Riley, D.J., and Gerecke, D.R. Perinatal Changes in the Collagen Fibril Structure of the Cervix. FASEB J. 19: A806, 2005. [accessed at http://select.biosis.org/faseb/faseb.html]

24. Gordon, M.K., Bhatt, P., Song, R., Hahn, R.A., Shakarjian, M., Gerecke, D. R. and Koch,M. Collagen XXIII Facilitates Adhesion of Corneal Epithelial Cells to Type IV Collagen and Matrigel. ARVO Meeting Abstract, May 2005.

25. Gordon, M.K., Hahn, R.A., Zhou, P., Morio, L., Laskin, D. and Gerecke, D. R. Liver fibrosis is associated with changes in collagen fibril diameter and a shift in collagen type expression. 2006 Experimental Biology meeting abstracts FASEB J. 20: A307.5, 2006 [url= http://www.eb2006-online.com/viewsession.php?id=307&PHPSESSID=f07543fef8761587d860af5e0239a3bf].

26. Chang, Y.-C., Gordon, M.K., Shakarjian, M.P., Riley D.J., and Gerecke, D.R. Up-regulation of the gamma-2 chain of laminin-332 (laminin-5) in wounded mouse ears.

2006 Experimental Biology meeting abstracts FASEB J. 20:A565.4, 2006 [url=http://www.eb2006-online.com/viewsession.php?id=565&PHPSESSID=f07543fef8761587d860af5e0239a3bf]

27. Gordon, M.K., Hahn, R.A., Tovar, N., Olsen, B.R., Reichenberger, E., Dunn, M.G. and Gerecke, D. R. Corneas of Transgenic Mice Secreting Reduced Amounts of Type XII Collagen Have Altered Biomechanical Properties. ARVO Meeting Abstract, May 2006.

28. Shakarjian, M.P., Ajibade, D.V., Black, A. T., Chang, Y., Gordon, M.K., Heck, D.E., Laskin, J.D., Riley, D.J., and Gerecke, D. R. Nitrogen Mustard-Induced Alterations Of Matrix Metalloproteinase-9 In Mouse Keratinocytes. The Toxicologist, A158, p. 33, 2007

29. Chang, Y.-C., Zito, P.M., Sabourin, C.L.K., Casillas, R.P., Gordon, M.K., Hahn, R.A., and Gerecke, D.R. Microarray Analysis Of Murine Gene Upregulation After Cutaneous Sulfur Mustard Exposure. The Toxicologist A1853, p. 383, 2007..

30. Chao, M.-W., Pettit, A., Song, R., Gerecke, D.R., Laumbach, R., and Gordon, M.K. The Effect Of Diesel Particles On Capillary Endothelial Tubes Grown In Vitro. The Toxicologist A2111, p. 436, 2007.

31. Gordon, M.K., Hahn, R.A., Beloni, J., Gerecke, D.R. and Babin, M. In vitro culture of rabbit corneas for testing doxycycline as a countermeasure against mustard compounds. First Annual CounterACT Network Research Symposium, April 2007.

32. Chao, M.-W., Pettit, A., Gerecke, D.R., Laumbach, R., and Gordon, M.K. Treatment of Endothelial Cells in vitro with Varying Concentrations of Diesel Particles and Carbon Black. 2007 Experimental Biology meeting abstracts FASEB J. 21:73.5, 2007.

33. Gordon, M.K. Developmental Dynamics and Stromal Composition. ARVO Meeting Abstract (and invited presentation), May 2007 34. Gerecke, D.R., Sabourin, C.L., Svoboda, K.K., Lou, S., Gordon, M.K., Casillas, R.P. and

Chang, Y.C. Sulfur Mustard Induced Changes in Laminin-332 in the Mouse Ear Vesicant Model (MEVM). The Toxicologist A155, p. 31, 2008.

35. Chang, Y.C., Casillas, R.P., Sabourin, C.L., Laskin, J.D., Gordon, M.K. and Gerecke, D.R. Differential Gene Expression in Sulfur Mustard Treated Murine Skin after Treatment with MMP-2/MMP-9 Inhibitor I. The Toxicologist A683, p. 129, 2008.

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36. Chao, M.-W., Po, P.-W., Koslosky, J, Gerecke, D.R., Laumbach, R., and Gordon, M.K. Changes in Endothelial Tube Cell-Cell Borders in Response to Diesel Exhaust Particles. The Toxicologist A742, p. 152, 2008.

37. Huang, M., Gray, J. P., Black, A. T., Gerecke, D. R., Gordon, M. K., Gallo, M. A., Heindel, N. D., Sinko, P. J., Casillas, R. P., Dyer, R. B., Chung, C. S., Laskin, D. L., Laskin, J. D., and Heck, D. E. Vesicant Injury Increases Expression Of Matrix Degrading Enzymes And Inflammatory Mediators In A Mouse Ear Model. The Toxicologist A1545, p. 317, 2008.

38. Gerecke, D.R., Gordon, M.K., Svoboda, K., Lu, S.-E. and Chang, Y.-C. Spatial and Temporal Similarities between Laminin-332 and Keratin-5 during Wound Repair. FASEB J. 22:582.2, 2008.

39. Gordon, M.K. Histology and Organization of the Fascia, in MASTER CLASS: PHYSICAL THERAPY & FASCIA FASEB J. 22:10.1, 2008. 40. DeSantis, A., Hahn, R. A., Beloni, J., Gerecke, D.R. and Gordon, M.K. An Organ Culture

Model For Studying Corneal Wound Healing. FASEB J. 22:582.3, 2008. 41. Chao, M-W, Po, P.-W., Koslosky, J., Gerecke, D.R., Laumbach, R., Svoboda, K.K.H. and

Gordon, M. K. Capillary Endothelial Tubes Lose Cell Junctional Integrity And Apoptose In Response To Diesel Exhaust Particles. FASEB J. 22:524.8, 2008.

42. DeSantis, A., Hahn, R.A., Beloni, J., Gerecke, D.R., Svoboda, K.K.H. and Gordon, M.K. Doxyclycine Promotes Healing of Corneal Injuries Induced by Half

Mustard (CEES). IOVS 49: ARVO E-Abstract 3386, 2008. 43. Gordon, M.K., Hahn, R.A., Beloni, J., Dilworth, D., and Gould, D. Expression of Transmembranous Collagen XXIII in the Developing Mouse Cornea. IOVS 49: ARVO

E-Abstract 3372, 2008. 44. Gordon, M.K., De Santis, A., Hahn, R.A., Beloni, J., Gerecke, D.R., Svoboda, K.K

and Babin, M.C. Doxycycline and Tobradex as Countermeasures Against Mustard Exposures Using a Rabbit Corneal Organ Culture Model System. 16th Biennial Medical Chemical Defense Bioscience Review 2008 meeting abstract.

45. Gordon MK, DeSantis A, Hahn RA, Beloni J, Gerecke DR, and Babin MC. Attenuation of vesicant injury by doxycycline and tobradex in a rabbit corneal organ culture system. Proc. Biosci. Review, 124, June, 2008

46. Hahn, R.A., Schlager, J., DeSantis, A., Gallo, M.A., Heck, D., Sinko, P., Laskin, D.L., Laskin, J.D., Heindel, N., Casillas, R., Gerecke, D.R., Babin, MC and Gordon, M.K. Doxycycline And Tobradex Suppress Rabbit Corneal Basement Membrane Zone Damage Induced By 2-Chloroethyl Ethyl Sulfide. The Toxicologist A549, p 115, 2009.

47. DeSantis, A., Hahn, R.A., Beloni, J., Svoboda, K.K.H., Gerecke, D.R., Babin, MC and Gordon, M.K. Countermeasures Against Nitrogen Mustard Injury to the Cornea. The Toxicologist A547, p115, 2009.

48. Gerecke D, Soriano M, Casillas RP, Sabourin CL, Gordon MK, and Chang Y. Sulfur mustard-induced endoplasmic reticulum stress response in the mouse ear vesicant model. The Toxicologist A617, p129, 2009.

PERSONS EMPLOYED Research Assistant Professors:

Gordon, Marion K.

20

Bo Feng, Ph.D. (University of Maryland, 1991), M.D. (Tianjin Medical University, 1982):

2007-2008. Current Professional Address: School of Pharmacy, Rutgers University, EOHSI, Piscataway, NJ.

Research Associates:

Rita A. Hahn, M.S.: 1999-present, Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, EOHSI, Piscataway, NJ.

Peihong Zhou, M.D.: 2000-2004. Current Professional Position: Research Assistant Professor, Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, EOHSI, Piscataway, NJ.

Jeibo Lu, M.D.: 2008-present, Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, EOHSI, Piscataway, NJ.

Research Assistants:

Joseph W. Foley, B.S.: 1991- 1995. Current Professional Address: Genzyme Corporation, Framingham, MA.

Jessica E. Foley, B.S.: 1994-1999. Current Professional Address: South Shore Hospital, Weymouth, MA

Pinaki Bhatt B.S.: 2001-2004. May 2001 graduate of Rutgers University (Biochemistry major).Current Professional Address: Chanel, Inc., Piscataway, NJ.

Richard Song, B.S.: 2001-2006. May 2001 graduate of Rutgers University (Biochemistry major).Current Professional Address: Temple University School of Pharmacy, Philadelphia, PA.

John Beloni, B.S. 2007-present. Current Professional Address: School of Pharmacy, Rutgers University, EOHSI, Piscataway, NJ

STUDENTS TRAINED Medical or Graduate Students:

Peiwen Po: 2008-present. Advisor. Ph.D. Student at Rutgers University/UMDNJ, Robert Wood Johnson Medical School Joint Graduate Program in Toxicology. Title of current project: Evaluation of Tocopherols to Offset the Adverse Effects of Diesel Exhaust Particles on Capillary Endothelial Cells.

Andrea DeSantis: 2007-present. Advisor. Ph.D. Student at Rutgers University/UMDNJ, Robert Wood Johnson Medical School Joint Graduate Program in Toxicology. Title of current project: Countermeasures against Corneal Mustard Exposures.

Ashley Petit: 2006 Rotation Ph.D. Student at Rutgers University/UMDNJ, Robert Wood Johnson Medical School Joint Graduate Program in Toxicology.

Ming Wei Chao: 2005-present. Advisor. Ph.D. Student at Rutgers University/UMDNJ, Robert Wood Johnson Medical School Joint Graduate Program in Toxicology. Title of current project: Effect of Diesel Particles on Cell-Cell Junctions of Capillary Endothelia.

Nagarani Ramasubramaniam: Co-advisor. 2000-2001 B.S./MD Student at Rutgers University/UMDNJ, Robert Wood Johnson Medical School joint program. Title of

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project: Immunofluorescence of Collagens in Utero-Sacral Ligaments of Prolapsed and Non-Prolapsed Uteri.

Theresa Willet: 1996-1997 Rotating student at Tufts Medical School MD/Ph.D. program, Cell, Molecular and Developmental Biology. Title of project: Isolation of a bone specific FACIT collagen.

Janine Quigley: 1995-1996 Rotating student in Tufts Medical School Ph.D. program in Cell, Molecular and Developmental Biology. Title of project: Cloning and sequencing of the chick � 1(XIV) collagen gene.

Pharmacy Doctoral Honors Students:

William Vincent: 2003-present. Rutgers University Ernest Mario School of Pharmacy honors Pharm. D. student doing independent research project. Title of project: Extracellular Matrix Changes associated with Cervical Softening.

Andrew Kistler: 2001-present. Rutgers University Ernest Mario School of Pharmacy honors Pharm. D. student doing independent research project. Title of project: Extracellular Matrix Molecule Alterations in Umbilical Arteries of Growth Restricted Fetuses.

Pharmacy Doctoral students:

Emeri Potter: Spring 2007-present. Rutgers University Ernest Mario School of Pharmacy Pharm. D. student doing independent research project. Title of project: Involvement of Extracellular Matrix and Matrix Metalloproteinases in Sarcoidosis.

Lauren Von Dollen: spring 2007. Rutgers University Ernest Mario School of Pharmacy Pharm. D. student doing an independent research project. Title: Expression of Matrix Metalloproteinase-9 with progressing lung fibrosis. Jean Kim: spring 2007. Rutgers University Ernest Mario School of Pharmacy Pharm. D. student doing an independent research project. Title: Perinatal Changes in Collagen Isotype Expression in Pulmonary Arteries of Rats.

Christine Sunwoo: fall 2006 and spring 2007. Rutgers University Ernest Mario School of Pharmacy Pharm. D. student doing and independent research project. Title: Ultrastructure of the cornea in transgenic mice making reduced quantities of type XII collagen.

Patrick Zito: summer 2006. Rutgers University Ernest Mario School of Pharmacy Pharm. D. student doing an independent research project. Title: Microarray analysis of sulfur mustard treated skin.

Alicia Burke: spring 2003. Rutgers University Ernest Mario School of Pharmacy Pharm. D. student doing an independent research project. Title: Extracellular matrix molecules involved in premature rupture of fetal membranes.

Pharmacy Bachelor students: Falguni Shukla: spring 2001. Rutgers College of Pharmacy student doing independent

research project in collaboration with Dr. Jun Yan Hong. Alexander Chan: summer 2000. Rutgers College of Pharmacy student independent research

project. Title: EMMPRIN in normal and tumor cells. Lakshmi Sharma: summer 1999. Rutgers College of Pharmacy student summer research

project. Title: Role of Collagen XIV in Hypoxic Pulmonary Vessels. Undergraduates (Rutgers and other universities):

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Kim LeMoon: 2007-present. Rutgers University (Douglass) freshman (undeclared major) enrolled in Project SUPER, a program of “the Douglass Project for Rutgers Women in Math, Science and Engineering.” Title of Research Project: Collagen Organization in Various Fascia.

Alex Peng: 2007-present. Rutgers University freshman (undeclared major) doing an independent research project. Title: Expression of Recombinant Rabbit Collagen XVII for Antibody Generation.

Peiwen Po: 2006-2008. Rutgers University Cell Biology major doing an independent research project. Title: Characterization of Endothelial Cells after Diesel Particle Exposure.

Payal Garg: summer 2001. Massachusetts Institute of Technology (MIT) Biology major doing a summer research project. Title of project: Electron Microscopic Analyses of Collagen Fibril Diameter Changes in Pulmonary Arteries as a Result of Hypertension.

Richard Song: 2000-2001. Rutgers University Biochemistry major doing independent research project. Title: Construction and Expression of a Full Length Collagen XX Construct, and Characterization of the Protein with an Anti-Collagen XX Antibody.

Pinaki Bhatt: 1999-2001. Rutgers University Biochemistry major doing independent research project. Title: Characterization of a Novel Transmembrane Collagen, Type XXIII.

Manju Goyal: 1999-2000. Rutgers University Biochemistry major doing independent research project. Title: Involvement of Collagen XII in Pulmonary Hypertension.

Awards Won by Students Trained

Ming Wei Chao: Society of Toxicology In Vitro and Alternative Methods Specialty Section

Student Poster Award, March 2009, $500 prize. Advisor: Marion K. Gordon

Rutgers Undergraduate Research Fellowship, 7/1/03-6/30/04 Cervical Softening as a Function of Collagen Fibril Structure

Direct Costs: $1,500 (selected by Johnson and Johnson for corporate funding) Awarded to William Vincent, III, Pharm.D. Honors Student Advisor: Marion K. Gordon

Rutgers Undergraduate Research Fellowship, 7/1/02-6/30/03

Extracellular Matrix Changes in Fetal Growth Restricted Umbilical Arteries Direct Costs: $1,500 (selected by Johnson and Johnson for corporate funding) Awarded to C. Andrew Kistler, Pharm.D. Honors Student Advisor: Marion K. Gordon