Curriculum Vitae Anthony A. Mikulec, MD, MBA, FACS

Personal Information 3635 Vista Avenue, 6FDT • St. Louis, MO 63110 Phone: 314-577-8885 Fax: 314-268-5111 Email: anthony.mikulec@health.slu.edu

Current Position Saint Louis University School of Medicine

Professor, with tenure 07/15–Present Department of Otolaryngology–Head and Neck Surgery Director, Otologic and Neurotologic Surgery Director, Temporal Bone Laboratory

Director of Faculty

Bander Center for Medical Business Ethics 07/12–Present

Education Postgraduate training:

Fellowship - Neurotology and Skull Base Surgery 07/02–06/04 Harvard University, Boston, MA

Residency – Otolaryngology 07/98–06/02 Stanford University, Stanford, CA

Internship – General Surgery 07/97–06/98 Stanford University, Stanford, CA

MBA, Business – Saint Louis University, St. Louis, MO 09/05–06/09 MD, Medicine – Stanford University, Stanford, CA 08/93–06/97 BA, Biology – Stanford University, Stanford, CA 09/89–06/93 BS, Quantitative Economics – Stanford University, Stanford, CA 09/89–06/93

Previous Professional experience Saint Louis University School of Medicine

Associate Professor 06/09 – 06/15 Department of Otolaryngology–Head and Neck Surgery Director of Otologic and Neurotologic Surgery Director of Temporal Bone Laboratory

Assistant Professor 07/04 – 06/09 Department of Otolaryngology–Head and Neck Surgery Director of Otologic and Neurotologic Surgery Director of Temporal Bone Laboratory

Hospital and Clinical Staff appointments Mercy Medical Center, Staff 07/04–Present Cardinal Glennon Children’s Hospital, Staff 07/04–Present Saint Louis University Hospital, Staff 07/04–Present

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Board Certification and Licensure American Board of Otolaryngology, Subspecialty of Neurotology No. 17158 2005–Present American Board of Otolaryngology, Otolaryngology No. 17158 2003–Present Missouri License, No. 2004011779 2004–Present Massachusetts Limited License 2002–2004 California Medical License, A066305 1998–Present DEA 1998–Present

Professional Society memberships International

The International Otopathology Society a.k.a The Schuknecht Society National

The Association for Research in Otolaryngology American Academy of Surgery, Fellow North American Skull Base Society American Academy of Otolaryngology Head and Neck Surgery

Honorary Societies, Honors and Awards Best Doctors in America 2016 Best Doctors in America 2015 Best Doctors, Awarded by St. Louis Magazine 2013–2018 Professionalism in Article Prize, Awarded by The ABIM Foundation 2014 Best Patent of 2011, Awarded by Draper Lab 2011 Honorable Mention, Idea to Product Competition 2008 Beta Gamma Sigma MBA Honors Society 2008 Academic Professor of the Year, voted by SLU Oto Residents 2007 Triological Society Western Sectioon Vice Presendent’s Award 2001 1st Place: Basic Science, Bay Area Residents Research Symposium 2001 Advisor of Merit 1998 Dean’s Award for Research 1997 Excellence in Teaching Award 1993 Saturn Award for Teamwork 1990

Professional Services Committee membership and administrative role

International International Working Group on Endoscopic Ear Surgery 2013–Present

National Association for Research in Otolaryngology 2009–2010 Patient Advocacy Committee

University Faculty Senator, Saint Louis University 2015–2017 Faculty Senator, Saint Louis University 2007–2008

Department Member, Otolaryngology Finance Committee 2008–Present Member, Otolaryngology Resident Education Committee 2007–Present Member, Executive Committee of the Faculty 2009–2012

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Director, Resident Research 2005–2009 Director, Research Scientists Recruitment for Otolaryngology Department 2005–2009 Director, Temporal Bone Laboratory Otolaryngology Department 2004–Present

Community Member, Billiken Angels Network 2010–Present

Editorial and Journal review boards

Adhoc reviewer, Journal of Computer Aided Surgery 2011–Present Adhoc reviewer, International Journal of Audiology 2008–Present Adhoc reviewer, Audiology & Neurotology 2007–Present Adhoc reviewer, International Journal of Pediatric Otolarynology 2007–Present Adhoc reviewer, Annals of Otolaryngology 2006–Present Adhoc reviewer, Otology and Neurotology 2005–Present

Curent and Past Teaching Responsibilities Saint Louis University School of Medicine 2005–Present

Neuroscience Class for Medical Students, 2 hour lecture/year Saint Louis University – Department of Otolaryngology 2004–Present

Hands on teaching of residents 20 hours a week

Protégé Resident Research Rotation Preceptor (3 month block)

Zachary Bear, MD: Canal Dehiscence 2013 Martin Anderson, MD: Pediatric Consent Delphi Analysis 2012 Gaurav Prasad, MD: Radiation Cochleotoxicity 2011 Timothy McEvoy, MD: Hearing Loss in Canal Dehiscence 2010 Internet Based Consent John Chastain, MD: Balance Assessment with John Epley, MD 2006 Robert Mynatt, MD: Inner Ear Drug Delivery 2005

Audiology Intern Research Rotation Preceptor with Dave Harris, PhD Stephanie Wieczorek, AuD: Enlarged Vestibular Aqueduct 2012 Sarah Carls, AuD: Autoimmune Ear Disease 2011

Medical Students

Antoinette Hu, SLU Medical Student: Delphi Consent Analysis 2016 Farhoud Faraji, SLU Medical Student: Treatment of Acoustic Neuroma 2016 Edward Doyle, SLU Medical Student: Treatment of Acoustic Neuroma 2015 Hashir Saeed, SLU Medical Student: Maintenance of Certification in Otolaryngology 2013 Michael Darley, SLU Medical Student: Bone anchored hearing aid 2010 Farhoud Faraji, SLU Medical Student: Evaluation of Orthostasis 2009 Dmitry Blumenkrantz, SLU Medical Student: Modeling of 2008

Dexamethasone Delivery to the Inner Ear

Undergrad Students Joseph Roth, Undergraduate: Internet Based Consent Forms 2007 Jordan McMillin, Undergraduate: Inner Ear Drug Delivery Method 2007 Katie Kowalczyk, Undergraduate: Association of BPPV and Osteoporosis 2007

High School Students Ward Hanser, High School Student: Automobile Noise Exposure 2015 Theodore White, High School Student: Automobile Noise Exposure 2006

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Research Support Current funding

Funding Agency: Association of Migraine Disorders 2014–2018 Title: A Prospective, Randomized, Cross-over trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine

Past funding Funding Agency: Otonomy, Inc 2016–2017 Title: A 6-month, multicenter, Phase 3, open-label extension safety study of OTO-104 given at 3-month intervals by intratympanic injection in subjects with unilateral Meniere’s disease.

Funding Agency: Otonomy, Inc 2016–2017 Title: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 3 Efficacy and Safety Study of OTO-104 Given as a Single Intratypanic Injection in Subjects with Unilateral Meniere’s Disease

Funding Agency: Otonomy, Inc 2016 Title: A 1-month, prospective, randomized, double-blind, sham-controlled, multicenter, Phase 3 study of OTO-201 given as a single administration for treatment of acute otitis externa

Funding Agency: Otonomy, Inc 2013–2014 Title: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 2b Study of OTO-104 Given as a Single Intratypanic Injection in Subjects with Unilateral Meniere’s Disease

Funding Agency: Bander Center Ethics Fellowship 2010–2012 Title: The Physician and Patient Personal Responsibility Funding: $10,000 per year

Funding Agency: Otonomy, Inc. 2010–2011 Title: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 1B Study of OTO-104 Give as a Single Intratympanic Injection in Subjects with Unilateral Meniere’s Disease

Funding Agency: Otologics, LLC 2006–2009 Title: Fully-Implantable MET Ossicular Stimulator Clinical Trial Funding: $8,000 per patient enrolled

Funding Agency: The American Otological Society 2006–2008 Title: Optimization of Local Drug Delivery to the Cochlea Funding: 2 year period, $160,000; 8%

Funding Agency: Draper Laboratory 2002–2004 Title: Serum-free Evaluation of Trophic Factors in Wound Healing Funding: $100,000

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Funding Agency: Stanford University 1999–2002 Title: Serum-free Evaluation of Trophic Factors in Wound Healing Funding: $6,000

Funding Agency: Stanford University Medical Scholars 1994–1995 Research Grant Title: Anesthetic Depression at Pre-Synaptic Sites in the In-Vitro Hippocampus Funding: $19,081

Funding Agency: Stanford University 1991–1993 Title: Peptide and Growth Factor on Wound Healing in a Corneal Whole Mount Preparation Funding: $10,000

Funding Agency: Henry Ford Hospital 1992–1993 Title: CTF/NF-1 Expression in Rat Mammary Tissue Funding: $2,400

Bibliography Peer Reviewed Papers

1. Mikulec AA, Lukatch HS, Monroe FA, MacIver MB. Diltiazem spares corneal A delta mechano and C fiber cold receptors and preserves epithelial wound healing. Cornea 1995 Sept;14(5)490-6.

2. Mikulec AA, Tanelian DL. CGRP increases the rate of corneal re-epithelialization in an in vitro whole

mount preparation. J Ocul Pharmacol Ther. 1996 Winter;12(4)417-23.

3. MacIver MB, Amagasu SM, Mikulec AA, Monroe FA. Riluzole anesthesia: Use-dependent block of presynaptic glutamate fibers. Anesthesiology 1996 Sept;85(3)626-34.

4. MacIver MB, Mikulec AA, Amagasu SM, Monroe FA. Volatile anesthetics depress glutamate

transmission via presynaptic actions. Anesthesiology.1996 Oct;85(4):823-34.

5. Mandpe AH, Mikulec A, Jackler RK, Pitts LH, Yingling CD. Comparison of response amplitude versus stimulation threshold in predicting early postoperative facial nerve function after acoustic neuroma resection. Am J Otol. 1998 Jan;19(1):112-7.

6. Mikulec A, Pittson S, Amagasu SM, Monroe FA, MacIver MB. Halothane depresses action potential

conduction in hippocampal axons. Brain Res. 1998 Jun 15;796(1-2):231-8.

7. Pollard JD, Hanasono MM, Mikulec AA, Le QT, Terris DJ. Head and neck cancer in cardiothoracic transplant recipients. Laryngoscope. 2000 Aug;110(8):1257-61.

8. Mikulec AA, Hanasono MM, Kadleck JM, Lum J, Kita M, Koch RJ. Effect of tamoxifen on transforming

growth factor beta1 production by keloid and fetal fibroblasts. Arch Facial Plastic Surg. 2001 Apr- Jun;3(2):111-4.

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9. Carroll LA, Hanasono MM, Mikulec AA, Kita M, Koch RJ. Triamcinolone stimulates bFGF production and inhibits TGF-beta1 production by human dermal fibroblasts. Dermatol Surg. 2002 Aug;28(8):704-9.

10. Hanasono MM, Kita M, Mikulec AA, Lonergan D, Koch RJ. Autocrine growth factor production by fetal,

keloid, and normal dermal fibroblasts. Arch Facial Plast Surg. 2003 Jan-Feb;5(1):26-30.

11. Lonergan DM, Mikulec AA, Hanasono MM, Kita M, Koch RJ. Growth factor profile of irradiated human dermal fibroblasts using a serum-free method. Plast Reconstr Surg. 2003 May;111(6):1960-8.

12. Mikulec AA, McKenna MJ, Ramsey MJ, Rosowski JJ, Herrmann BS, Rauch SD, Curtin HD, Merchant SN.

Superior semicircular canal dehiscence Presenting as conductive hearing loss without vertigo. Otol Neurotol. 2004 Mar;25(2):121-9.

13. Hanasono MM, Lum J, Carroll LA, Mikulec AA, Koch RJ. The effect of silicone gel on basic fibroblast

growth factor levels in fibroblast cell culture. Arch Facial Plast Surg. 2004 Mar-Apr;6(2):88-93.

14. Hanasono MM, Lalakea ML, Mikulec AA, Shepard KG, Wellis V, Messner AH. Perioperative steroids in tonsillectomy using electrocautery and sharp dissection techniques. Arch Otolaryngol Head Neck Surg. 2004 Aug;130(8):917-21.

15. Mikulec AA. The physician-supply debate. N Eng J Med. 2004 Aug 26;351(9):934-5;author reply 934-5.

16. Clayton AE, Mikulec AA, Mikulec KH, Merchant SN, McKenna MJ. Association between osteoporosis and otosclerosis in women. J Laryngol Otol. 2004 Aug; 118(8):617-21.

17. Mikulec AA, Poe DS, McKenna MJ. Operative management of superior semicircular canal dehiscence. Laryngoscope. 2005 Mar; 115 (3): 501-7.

18. Chen Z, Mikulec AA, McKenna MJ, Sewell WF, Kujawa SG. A method for intracochlear drug delivery in

the mouse. J Neurosci Methods. 2006 Jan 15;150(1): 67-73. Epub 2005 Jul 25.

19. Mikulec AA, Poe DS. Operative management of a posterior semicircular canal dehiscence. Laryngoscope. 2006 Mar;116 (3):375-8.

20. Sarac S, McKenna MJ, Mikulec AA, Rauch SD, Nadol JB Jr, Merchant SN. Results after revision stapedectomy with malleus grip prosthesis. Ann Otol Rhinol Laryngol. 2006 Apr; 115 (4): 317-22.

21. Kita M, Hanasono MM, Mikulec AA, Pollard JD, Kadleck JM, Koch RJ. Growth and growth factor

production by human nasal septal chondrocytes in serum-free media. Am J Rhinol. 2006 Sept-Oct; 20 (5): 489-95.

22. Plontke SK, Mikulec AA, Salt AN. Rapid clearance of methylprednisolone after intratympanic

application in humans. Comment on Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol. 2008 Aug; 29(5):732-3; author reply 733.

23. Jones S, Harris DA, Estill A, Mikulec AA. Implantable hearing devices. Mo Med. 2008 May-Jun; 105(3):235-9.

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24. Moore MG, Lin DT, Mikulec AA, McKenna MJ, Varvares MA. The occipital flap for reconstruction after lateral temporal bone resection. Arch Otolaryngol Head Neck Surg. 2008 Jun; 134(6):587-91.

25. Mikulec AA, Hartsock JJ, Salt AN. Permeability of the round window membrane is influenced by the

composition of applied drug solutions and by common surgical procedures. Otol Neurotol. 2008 Oct; 29(7):1020-6.

26. Mikulec AA, Khan AM, Barker FG, McKenna MJ. Bilateral meningoencephalocele repair complicated by superior semicircular canal dehiscence: Case Report. Skull Base. 2008 Nov; 18(6):423-8.

27. Mikulec AA, Plontke SK, Hartsock JJ, Salt AN. Entry of substances into perilymph through the bone of

the otic capsule following intratympanic applications in guinea pigs: implications for local drug delivery in humans. Otol Neurotol. 2009 Feb;30(2):131-8.

28. Mikulec AA. Placement of the Baha osseointegrated implant in children. Op Tech Oto Head Neck Surg. 2009 Sep;:20(3):197-201.

29. Mikulec AA, Kowalczyk KA, Pfitzinger ME, Harris DA, Jackson LE. Negative Association between

treated osteoporosis and benign paroxysmal positional vertigo in women. J Laryngol Otol. 2010 Apr; 124(4):374-6. Epub 2009 Nov 25.

30. Mikulec AA, Lukens SB, Jackson LE, DeYoung MN. Noise Exposure in Convertible Automobiles. J

Laryngol Otol. 2011 Feb; 125(2):121-5. Epub 2010 Nov 25.

31. Faraji F, Kinsella LJ, Rutledge JC, Mikulec AA. The Comparative Usefulness of Orthostatic Testing and Tilt Table Testing in the Evaluation of Autonomic-Associated Dizziness. Otol Neurotol. 2011 Jun;32(4):654-9.

32. Mikulec AA. Am I on call for the entire Midwest? Narrat Inq Bioeth. 2011 Fall;1(2):72-4.

33. Mikulec AA, Faraji F, Kinsella LJ. Evaluation of the efficacy of caffeine cessation, nortiptyline, and topiramate therapy in vestibular migraine and complex dizziness of unknown etiology. Am J Otolaryngol. 2012 Jan-Feb;33(1):121-7. Epub 2011 Jun 24.

34. Mikulec AA, Kinsella LJ. Subacute brainstem necrosis: a complication of sterotactic radiotherapy for skull base meningioma. Otol Neurotol. 2011 Sep;32(7):e50-1.

35. Bierut, LJ, Cruz-Flores S, Hodges LE, Mikulec AA, Nagaldinne GK, Bakanas E. Conflicting Interest in

Medicine. Narrative Inquiry in Bioethics. 2011 Fall;1(2):67-90.

36. Anderson ME Jr, Mikulec AA. Hearing tests in ophthalmology offices? I don’t like the sound of that! Mo Med. 2013 Jan-Feb; 110(1):44-6.

37. Dubois JM, Kraus EM, Mikulec AA, Cruz-Flores S, Bakanas E. A Humble Task: Restoring Virtue in an Age

of Conflicted Interests. Acad Med. 2013 Jul;88(7):924-928.

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38. McEvoy TP, Mikulec AA, Arbrecht ES, Lowe ME. Quantification of hearing loss associated with superior semi-circular canal dehiscence. Am J Otolaryngol. 2013 Jul-Aug;34(4):345-9. Epub 2013 Feb 8.

39. Darley MD, Mikulec AA. Survival of the 8.5mm osseointegrated abutment and its utility in the obese

patient. J Laryngol Otol. 2013 Jul;127(7):643-9. Epub 2013 May 30.

40. Harris DA, Mikulec AA, Carls SL. Autoimmune inner ear disease preliminary case report: audiometric findings following steroid treatment. Am J Audiol. 2013 Jun;22(1):120-4.

41. Mikulec AA. Response to “Comparison of plaintiff and defendant expert witness qualification in

malpractice litigation in otolaryngology”. Otolaryngol Head Neck Surg. 2013 Oct; 149(4):649.

42. Wieczorek SS, Anderson ME Jr, Harris DA, Mikulec AA. Enlarged vestibular aqueduct syndrome mimicking otosclerosis in adults. Am J Otolaryngol. 2013 Nov-Dec;34(6):619-25.

43. Saeed HK, Mikulec AA. Acceptance of Neurotology Board Certification Among Leaders in the Field. Otol Neurotol. 2014 Apr 28. Epub ahead of print.

44. Bear ZW, Mikulec AA. Intratympanic steroid therapy for treatment of idiopathic sudden sensorineural

hearing loss. Mo Med. 2014 Jul-Aug; 111(4): 352-6.

45. DuBois JM, Kraus EM, Gursahani K, Mikulec A, Bakanas E. Curricular priorities for business ethics in medical practice and research: recommendations from Delphi consensus panels. BMC Med Educ. 2014 Nov 15;14:235.

46. Bear ZW, McEvoy TP, Mikulec AA. Quantification of hearing loss in patients with posterior semicircular canal dehiscence. Acta Otolaryngol. 2015;135(10):974-7.

47. Gasser Rutledge KL, Prasad KG, Emery KR, Mikulec AA, Varvares M, Gratton MA. Short-term Peripheral

Auditory Effects of Cranial Irradiation: A Mouse Model. Ann Otol Rhinol Laryngol. 2015 Jun 17. Epub ahead of print.

48. Bear ZW, Mikulec AA. Turn on the Music: Cochlear Implants. Mo Med. 2016 Jan-Feb;113(1)68-71.

49. Abdulrauf SI, Ashour AM, Marvin E, Coppens J, Kang B, Hsieh TY, Nery B, Penanes JR, Alsahlawi AK, Moore S, Abou Al-Shaar H, Kemp J, Chawla K, Sujijantarat N, Najeeb A, Parkar N, Shetty V, Vafaie T, Antisdel J, Mikulec TA, Edgell R, Lebovitz J, Pierson M, Pires de Aguiar PH, Buchanan P, Di Cosola A, Stevens G. Proposed clinical internal carotid artery classification system. J Craniovertebr Junction Spine. 2016 Jul-Sep;7(3):161-70.

50. Karimnejad K, Czerny MS, Lookabaugh S, Lee DJ, Mikulec AA. Gender and laterality in semicircular

canal dehiscense syndrome. J Laryngol Otol. 2016 August (8); 130:712-6.

51. Pierson M, Marwaha N, Guzman M, Mikulec AA, Coppens JR. Multifocal melanocytoma of the posterior fossa and subcutaneous scalp in the absence of neurocutaneous melanosis. Surg Neurol Int. 2016 Sep 1;7(Suppl 23):S591-5.

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52. Lambert PR, Carey J, Mikulec AA, LeBel C; Otonomy Ménièreʼs Study Group. Intratympanic Sustained- Exposure Dexamethasone Thermosensitive Gel for Symptoms of Ménière's Disease: Randomized Phase 2b Safety and Efficacy Trial. Otol Neurotol. 2016 Dec;37(10):1669-1676.

53. Jumaily M, Faraji F, Mikulec AA. Intratympanic Triamcinolone and Dexamethasone in the Treatment of Ménière's Syndrome. Otol Neurotol. 2017 Mar;38(3):386-391.

54. Karimnejad K, Akhter AS, Walen SG, Mikulec AA. The temporoparietal fascia flap for coverage of

cochlear reimplantation following extrusion. Int J Pediatr Otorhinolaryngol. 2017 Mar;94:64-67.

55. Hanser FHB, Adjei Boakye E, Mikulec AA. Intergenerational preferences for radio loudness during automobile driving. Int J Pediatr Otorhinolaryngol. 2017 Jul;98:64-67.

56. Thompson-Harvey A, Mikulec AA. Total caloric eye speed in patients with vestibular migraine. Am J Otolaryngol. 2018 Mar - Apr;39(2):180-183.

57. Jumaily M, Franco J, Gallogly JA, Hentzelman JL, Costa DJ, Wild APK, Mikulec AA. Butterfly cartilage

tympanoplasty outcomes: A single-institution experience and literature review. Am J Otolaryngol. 2018 Mar 29.

58. Gallogly JA, Jumaily M, Faraji F, Mikulec AA. Stereotactic radiotherapy in three weekly fractions for the

management of vestibular schwannomas. Am J Otolaryngol. 2018 Sep - Oct;39(5):561-566.

Book chapters 1. Mikulec AA. Congenital Hearing Loss (Sensorineural and Conductive). In: Mitchell RB, Perieira KD, eds.

Pediatric Otolaryngology for the Clinician. New York,NY: Humana Press; 2009:75.

2. Miller SM, Mikulec AA. Congenital Conductive Hearing Loss. In: Kountakis SE, ed. Encyclopedia of Otolaryngology Head and Neck Surg. New York, NY: Springer; 2011.

Abstracts and Presentations

1. Lukatch HS, Mikulec AA, Monroe FA, MacIver MB, Tanelian DL. Diltiazem disrupts wound healing at concentrations that block corneal C fiber discharge activity. Investigative Ophthalmology and Visual Science, 34(4):1321, 1993. (Podium)

2. Mikulec AA, Monroe FA, Tanelian DL. EGF and CGRP increase in vitro corneal epithelial wound healing. Investigative Ophthalmology and Visual Science, 34(4):1376, 1993. (Podium)

3. Amagasu SM, Mikulec AA, Monroe FA, MacIver MB. Anesthetics produce differential effects on EPSP

facilitation. Soc. Neuroscience, 20(2):1340, 1994. (Poster)

4. Amagasu SM, Mikulec AA, MacIver MB (1994) Halothane-induced depression of axonal conduction in mammalian CNS fibers. Anesthesiology, 81(3A):A-1475, 1994. (Poster)

5. Mikulec AA, Amagasu SM, Monroe FA, MacIver MB. Isoflurane and halothane produce opposite

effects on facilitation of excitatory synaptic responses in CA 1 neurons. Anesthesiology, 81(3A):A- 1476, 1994. (Podium)

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6. Mikulec AA, Amagasu SM, Monroe FA, MacIver MB. Three sites of action are necessary and sufficient for halothane-induced depression of hippocampal CA 1 neurons. Anesthesiology, 83(3A):A1266, 1995. (Podium)

7. Hanasono MM, Carroll LA, Ronson S, Mikulec AA, Koch RJ. Wound healing enhancement by modulation of fibroblast autocrine growth factors using tamoxifen. American Academy of Facial Plastic and Reconstructive Surgery Spring Meeting. Orlando, FL, 2000. (Poster)

8. Mikulec AA, Hanasono MM, Kadleck JM, Lum J, Kita M, Koch RJ. Effect of tamoxifen on TGF-B1

production by keloid and fetal fibroblasts. American Academy of Facial Plastic and Reconstructive Surgery Spring Meeting. Orlando, FL, 2000. (Poster)

9. Hanasono MM, Lum J, Carroll LA, Mikulec AA, Koch RJ. Silicone gel increases basic fibroblast growth

factor levels in fibroblast cell culture. American Academy of Facial Plastic and Reconstructive Surgery Fall Meeting. Denver, CO, 2001. (Podium)

10. Mikulec AA, Lonergan DM, Hanasono MM, Carroll LA, Kadleck JM, Koch RJ. Effect of tamoxifen on bFGF production in normal and keloid producing human dermal fibroblasts in vitro. American Academy of Facial Plastic and Reconstructive Surgery Fall Meeting. Denver, CO, 2001. (Podium)

11. Hanasono MM, Kita M, Mikulec AA, Lonergan D, Koch RJ. Autocrine growth factor production by fetal,

keloid, and normal dermal fibroblasts. American Academy of Facial Plastic and Reconstructive Surgery Spring Meeting. Palm Desert, CA, 2001. (Poster)

12. Mikulec AA, Lonergan D, Carroll LA, Kita M, Kadleck JM, Koch RJ. A serum free model for growth of irradiated human dermal fibroblasts in vitro. Triologic Society Meeting (Western Section), Carlsbad, CA and Bay Area Resident's Research Symposium. Oakland, CA, 2001. (Podium)

13. Hanasono MM, Lalakea ML, Mikulec AA, Shepard KG, Messner AH. Use of preoperative steroids in

patients undergoing tonsillectomy using "hot" and "cold" surgical techniques. American Society of Pediatric Otolaryngology Annual Meeting. Boca Raton, FL, 2002. (Podium)

14. Zhiqiang C, Mikulec AA, McKenna MJ, Sewell WF, Kujawa SG. A method for Intracochlear Drug

Delivery in the Mouse. Association for Research inOtolaryngology, The 28th Annual Mid-Winter Meeting. New Orleans, LA, February 2005 (Poster)

15. Khan AM, Mikulec AA. Cochlear Implantation in the Common Cavity Deformity. American Academy of Otolaryngology – Head and Neck Surgery Foundation, Inc. Annual Meeting. Los Angeles, CA. August 2005, 133 (2) 234. (Poster)

16. Mikulec AA, Salt AN. Factors Influencing Round Window Membrane Permeability in Guinea Pigs.

Association for Research in Otolaryngology, MidWinter Research Meeting. February 11, 2007 Denver, CO. (Poster)

17. Harris DA, Shah R, Mikulec AA, Jones S. Case Study: Natural History of Hearing Loss in Superior Semi- Circular Canal Dehiscence. Presented at the American Auditory Society Annual Convention and Education Seminar. Scottsdale, AZ, March 2007. (Poster)

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18. Mikulec AA, Plontke SK, Hartsock JJ, Salt AN. Drugs enter the perilymph of guinea pigs through the bony otic capsule. Association for Research in Otolaryngology, MidWinter Research Meeting. Phoenix, AZ., February 19, 2008. (Poster)

19. Faraji F, Kinsella LJ, Rutlege JC, Mikulec AA. The Comparative Utility of Orthostatic Testing and Tilt Table Testing in the Evaluation of Autonomic-Associated Dizziness. Joint Research Symposium, AMA MSS and AMA RFS Interim Meeting. Houston, TX, November 6, 2009. (Poster)

20. Harris DA, Conoyer BM, Mikulec AA. Hearing Preservation During Cyberknife Treatment for Acoustic

Neuroma. Abstract accepted by American Auditory Society Annual Convention and Education Seminar. March 2011. (Poster)

21. Darley M, Mikulec AA. Survivability of the 8.5 mm Osseointegrated Abutment and its Utility in the

Obese Patient. Triological Meeting. Chicago, IL, April 2011. (Poster)

22. Mikulec AA, Darley M. An Analysis of Caloric Eye Speeds in Vestibular Migraine. Triological Meeting. Chicago, IL, April 2011. (Poster)

23. Carls SL, Harris DA, Mikulec AA. Autoimmune Inner Ear Disease: Oral versus Oral and Intratympanic

Steroid Treatment. American Auditory Society Annual Convention and Education Seminar. Scottsdale, AZ, March 2012. (Poster)

24. Mikulec AA, Bear Z. Quantification of hearing loss in posterior semicircular canal dehiscence. Otology

Jubilee. Halle, Germany, May 2014. (Podium)

25. Leach ME, Mikulec AA, Yalamanchali S. MRSA and Pediatric Cochlear Implantation. American Academy of Otolaryngology – Head and Neck Surgery Foundation, Inc. Annual Meeting. Dallas, TX, 2015. (Poster)

26. Lambert PR, Carey JP, Mikulec AA, Lebel CP. Ph2b Efficacy and Safety of Intratympanic OTO-104 in

Ménière’s Disease. American Academy of Otolaryngology – Head and Neck Surgery Foundation, Inc. Annual Meeting. Dallas, TX, 2015. (Podium)

27. Harris DA, Phillipps K, Mikulec AA, Lowe M, Keenan S. The Clinical Effectiveness of the Epley Omniax in

the Treatment for BPPV. American Auditory Society Annual Scientific and Technology Meeting Scottsdale, AZ, 03/2016. (Podium)

Supplemental Material Course Directorship

Course Co-Director, Saint Louis University School of Medicine Practical Anatomy – Endoscopic Ear Surgery & Advanced Otology Workshop Hands- on Cadaver Workshop

2015

Course Co-Director, Saint Louis University School of Medicine Practical Anatomy – Endoscopic Ear Surgery & Advanced Otology Workshop Hands- on Cadaver Workshop

2014

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Course Co-Director, Saint Louis University School of Medicine Practical Anatomy – Endoscopic Ear Surgery & Advanced Otology Hands-on Cadaver Workshop

2013

Course Co-Director, Saint Louis University School of Medicine Practical Anatomy – First USA Endoscopic Ear Surgery & Advanced Otology Hands-on Cadaver Workshop

2012

Course Co-Director, Charles University, Prague, Czech Republic Czech American Otolaryngology Days

2012

Course Co-Director, Saint Louis University School of Medicine Practical Anatomy – Otologic & Neurotologic Surgery Hands-on Cadaver Workshop

2011

Course Director, Saint Louis University School of Medicine Practical Anatomy – Otologic & Neurotologic Surgery Course

2010

Course Director, Saint Louis University School of Medicine Practical Anatomy – Otologic & Neurotologic Surgery Course

2009

Course Director, Saint Louis University School of Medicine Practical Anatomy – Otologic & Neurotologic Surgery Course

2008

Course Director, Saint Louis University School of Medicine Practical Anatomy – Otologic & Neurotologic Surgery Course

2007

Course Director, Saint Louis University School of Medicine Practical Anatomy – Otologic & Neurotologic Surgery Course

2006

Course Director, Saint Louis University School of Medicine Practical Anatomy – Otologic & Neurotologic Surgery Course

2005

Extramural Invited Lectures

Lecturer, 18th annual César Fernández - John Lindsay Lecture University of Chicago, Department of Surgery Topic: Inner Ear Drug Delivery

05/18

Course Faculty, Resident Temporal Bone Course University of Rochester, Department of Otolaryngology, Rochester, NY

04/18

Course Faculty, Endoscopic Ear Surgery: Two-Day Dissection Course Massachusettes Eye and Ear Infirmary, Boston, MA Topic: Endoscopic Cartilage Button Tympanoplasty

11/17

Panelist, Vanderbilt Sisson Otolaryngology Symposium, Vail, CO Topic: Skull Base Pathology: Management and Interesting Cases Topic: Otology Lightning Round I

02/17

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Course Faculty, Endoscopic Ear Surgery: Two-Day Dissection Course 10/16 Massachusettes Eye and Ear Infirmary, Boston, MA

Topic: Endoscopic Cartilage Button Tympanoplasty Panelist, Oticon Medical’s 2nd Summit of the Americas Meeting, San Diego, CA

09/16

Lecturer, International Symposium and Workshops on Inner Ear Medicine & Surgery 03/16

Prosper Ménière Society, Austria

Topic: Results from a phase 2b clinical trial to assess the safety and efficacy of

sustained-exposure dexamethasone thermosensitive gel for intratympanic

administration in subjects with Ménière’s Disease

Panelist, Vanderbilt Sisson Otolaryngology Symposium, Vail, CO 02/16

Course Faculty, Endoscopic Ear Surgery: Two-Day Dissection Course 2015 Massachusettes Eye and Ear Infirmary, Boston, MA

Topic: Endoscopic Cartilage Button Tympanoplasty

Topic: Complex Cases in Endoscopic Ear Surgery

Course Faculty, Co-Instructor, AAO-HNSF Annual Meeting 2015

Dallas, TX

Topic: Evaluating and Managing Superior Canal Dehiscence Syndrome

Course Faculty & Lecturer, European ORL-HNS 2015

Prague, Czech Republic

Topic: A prospective, randomized, double-blind, placebo-controlled, multicenter, phase

1b study of oto-104 given as a single intratympanic injection in subjects with unilateral

Ménière’s Disease

Course Faculty & Lecturer, European ORL-HNS 2015

Prague, Czech Republic

Topic: Endoscopic Cartilage Button Tympanoplasty

Course Faculty & Keynote Lecturer, European ORL-HNS 2015

Prague, Czech Republic

Topic: Vestibular Migraine

Course Faculty & Invited Panelist, European ORL-HNS 2015

Prague, Czech Republic

Topic: Hearing Preservation: Cochlear Implantation in the Real World

Course Faculty & Invited Panelist, European ORL-HNS 2015

Prague, Czech Republic

Topic: Envoy Esteem Experience in the USA

Panelist, Vanderbilt Sisson Otolaryngology Symposium, Vail, CO 2015

Panelist, Vanderbilt Sisson Otolaryngology Symposium, Vail, CO 2014

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Lecturer, Missouri Bar Annual Workers Compensation Seminar 2013

Panelist, Vanderbilt Sisson Otolaryngology Symposium, Vail, CO 2013

Lecturer, Tripler Army T-Bone Workshop, Honolulu, HI 2012

Panelist and Lecuturer, Vanderbilt Sisson Otolaryngology Symposium, Vail, CO 2012

Lecturer, Byron Bailey Society Graduation Speaker, University of Texas at Galveston 2011

Lecturer, American Neurotology Society Annual Meeting, Chicago, IL Topic: Advances in Molecular Diagostics and Therapeutics in Otology

2011

Course Faculty, Otology, Neurotology Updates & 4th Temporal Bone Course, Riyadh Military Hospital, Riyadh, Saudi Arabia Topic: Middle Ear and Mastoid Surgery

2010

Course Faculty, Otology, Neurotology Updates & 3rd Temporal Bone Course, Riyadh Military Hospital, Riyadh, Saudi Arabia Topic: Middle Ear and Mastoid Surgery

2009

Lecturer, American Academy of Otolaryngology – Head and Neck Surgery Annual Meeting, Chicago, IL Topic: Transitional and Basic Research Program Moderator

2008

Course Faculty & Lecturer, Czech Temporal Bone Course, Prague, Czech Republic Topic: Middle Ear and Mastoid Surgery

2008

Lecturer, 5th International Congress of the World Federation of Skull Base Societies, Vancouver, BC Topic: Management Decisions for Patients with Acoustic Tumors

2008

Course Faculty, Southwest Conference on Communicative Disorders, Albuquerque, New Mexico

2007

Topic: Association of Osteoporosis with Otosclerosis and Benign Paroxysmal Positional Vertigo Topic: Vestibular Physiology, Testing and Superior Semicircular Canal Dehiscence

Course Faculty, Stanford Otology & Neurotology Update 2006 Stanford University Medical Center, Sanford, CA Topic: Clinic Cartilage Button Tympanoplasty for Small Perforation Topic: The Superior Semicircular Canal Dehiscence Syndrome

Course Faculty, Endoscopic Surgery of the Sinuses and Eustachian 2006 Tube Sinus Course, Massachusettes Eye and Ear Infirmary, Boston, MA Topic: Superior Semicircular Canal Dehiscence Topic: Eustachian Tube Physiology

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Other Lectures

Lecturer, Saint Louis University School of Medicine Department of Neuropathology, Vestibular Disorders Topic: Vestibular Disorders Lecturer, Update in Otolaryngology Head and Neck Surgery St. Louis, MO

2013

2008

Topic: Implantable Hearing Devices

Lecturer, Saint Louis University Department of Otolaryngology Orientation Conference Topic: Care of the Otologic Patient

2007

Lecturer, Missouri State Medical Association Annual Convention Topic: Superior Semicircular Canal Dehiscence

2006

Lecturer, SSM St. Joseph Hospital of Kirkwood Grand Rounds Topic: Cochlear Implants, Balance Testing

2006

Patents and Technology Transfer

Drug Delivery Apparatus, Patent No. 7,867,193 B2 01/11

Community Service/Civic Activities Billiken Angels Network 2010–2018

Assess, mentor and fund promising university based translational technology

Free Cochlear Implant 2008 Arranged for a Romanian child to come to the U.S. and receive a free cochlear implant, with the surgery performed by me.

JFK Clinic Volunteer 2005–Present Provide free medical care 15 hours/year

Ronald McDonald Camp Couselor; Good times, Los Angeles, CA 1992–2000 Worked 4 – 10 days per year as a live-in counselor with pediatric cancer patients

Co-founder and director for East European Democracy 1989–1994 Stanford University. Received the Saturn Award for Teamwork. Sent 100 students to teach English in Czechoslovakia, hosted foreign students, and sent one ton of books to Eastern Europe.