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Olimpia Meucci, MD, PhD 1

CURRICULUM VITAE A. Name OLIMPIA MEUCCI, M.D., Ph.D. B. Professional Address Drexel University College of Medicine,

Department of Pharmacology and Physiology, 245 North 15th Street, Philadelphia, PA 19102

Tel: (215) 762 2597 Fax: (215) 762 2299 Email: [email protected] C. Education 1994 Ph.D., Neuropsycopharmacology and Toxicology, University of Naples,

School of Medicine, Naples, Italy. Thesis: “Calcium homeostasis in neuronal and endocrine cells: Involvement of Ca2+ in cellular toxicity and differentiation”

1990 Medical Residency, Pharmacology and Toxicology, University of Naples, School of Medicine, Naples, Italy. Thesis: “Pharmacological characterization of the effect of noradrenaline on intracellular calcium levels in tyroid cells

(PC Cl3): role of TSH in the response of noradrenergic receptors α1A and α1B”

1987 M.D. summa cum laude and distinguished honors, University of Naples, School of Medicine, Naples, Italy. Thesis: “Intracellular mechanisms regulating prolactin release: role of second messenger systems (Ca2+ and cAMP)”

D. Additional/Postgraduate Training 1985-1990 Summer training externship programs:

- July/Nov 1985: University of Virginia, Charlottesville, VA, School of Medicine, Institute of Internal Medicine, (Mentor: Robert M. MacLeod, Ph.D.)

- July/Nov. 1986: National Institutes of Health, NICHD, Bethesda, MD (Mentor: Julius Axelrod, Ph.D)

- Sept. 1987: EMBO Intensive Lecture Course “Transmembrane signaling from structure to function of channels and receptors” Pavia, Italy - Nov. 1988: V Course on “Cell Culture in Oncology” School of Oncology and Biomedical Sciences S. Margherita Ligure, Genoa, Italy - June 1989: Serono Course “Membrane Technology in Clinical Pathology,

Biochemistry and Pharmacology” Rome, Italy - Feb. 1990: I Course Molecular Biology in Pharmacology, Milan, Italy

1988-1990 Postdoctoral Fellow, Italian Association for Cancer Research (AIRC), University of Naples, School of Medicine, Naples, Italy Institute of Pharmacology, Mentor: Gennaro Schettini, M.D., Ph.D. 1991 Visiting Scientist, National Institutes of Health, Bethesda MD, National Institute of Child and Human Development Laboratory of Cellular and Molecular Neurophysiology, PI: James T. Russell,

PhD 1991-1994 Postdoctoral Fellow, University of Naples, School of Medicine, Naples, Italy Department of Neuroscience, Mentor: Gennaro Schettini, M.D., Ph.D.


E. Employment history 1994 Research Associate, AIDS Research Fellow The University of Chicago, Chicago IL Department of Pharmacology and Physiology PI: Richard J. Miller., Ph.D. William D. Mabie Professor of Neuroscience

1996 Research Assistant Professor The University of Chicago, Chicago IL Department of Neurobiology, Pharmacology and Physiology

2000 Assistant Professor Drexel University College of Medicine (formerly MCP-Hahnemann University) Philadelphia, PA Department of Pharmacology and Physiology

2004 Associate Professor Drexel University College of Medicine Philadelphia, PA Department of Pharmacology and Physiology

2008 Professor Drexel University College of Medicine Philadelphia, PA Department of Pharmacology and Physiology & Department of Microbiology and Immunology F. Certification and Licensure 1987 Italian Board of Certification for MDs G. Military service N/A H. Honors and Awards

1987 MD, Graduated with highest honors and academic mention for experimental thesis work, University of Naples, Federico II School of Medicine, Italy

1988-1990 Fellowship Award, Italian Association for Cancer Research (A.I.R.C.) 1993 Fellowship Award, Italian Association for Research in Neurology (ARIN) 1994-1996 Fellowship Award, Italian Institute of Public Health, AIDS Research 1999 The University of Chicago, 1st Annual Brain Research Institute Neuroscience

Day Award 2002/03 Excellence in Research Award, Drexel University 2003/04 Excellence in Research Award, Drexel University 2008- Journal of NeuroImmune Pharmacology, Editorial Board 2009 Editor: “Chemokine receptors and neuroAIDS: beyond the co-receptor function

and links to other neuropathologies”, Springer. 2010- Editorial Board (Reviews), Frontiers in Neurodegenerative Diseases 2010- Director, Center of Neuroimmunology and CNS Therapeutics, Institute of

Molecular Medicine and Infectious Diseases, Drexel University College of Medicine


2011 Executive Leadership in Academic Medicine program (ELAM); class of 2012 2011-2015 NAED Study Section Member I. Memberships and Offices in Professional Societies 1987-1994 Italian Society of Pharmacology 1989-present International Society for Neuroscience 1990-1994 Italian Society of Neurochemistry 1998-present American Association for the Advancement of Science 2001-present International Society of Neurovirology 2002-present International Society of Developmental Neurobiology 2004-present International Society on NeuroImmunePharmacology 2005 Co-Chair, Symposium “Cytokines, Chemokines, the Brain and HIV”, 11th SNIP

meeting April 2005 2006 Co-Chair, Session XI “Neurogenesis, hematopoiesis and cellular therapy”, 7th

ISNV meeting June 2006 J. Professional/Academic Committees and Administrative Service 1) Institutional: 2000-2004 MCP-Hahnemann/DUCoM Biosafety Committee

2001-2011 Pharmacology and Physiology Graduate Students Steering Committee

2001 Neuroscience Graduate Students Steering Committee

2002-present Medical Student Admission (Interviewer)

2003 Committee for evaluation of Research Fellowships to Medical Students (study section member; Chair B. Waterhouse)

2003,’08-11 Study Section, DUCoM Commonwealth University Research Enhancement Program (CURE) grants

2004-present MD/PhD Admission Committee

2005-2006 Ben Weiss Scholarship Committee

2005 Internal Advisory Committee - Spinal Cord Injury Program Project

2005-2010 Pharmacology and Physiology Preliminary Exams Committee 2006 Pharmacology & Physiology Comt. Graduate Student Selection (Shawn Award)

2006 Neuroscience Preliminary Exam Committee

2006-2010 MCBG Preliminary Exam Committee

2006-present Graduate and Postdoc Professional Development Committee

2006-present IMS/MMS students Advisor

2007-present MCBG Steering Committee

2007 Co-Director Graduate Pharmacology Course

2008- Infectious Diseases Advisory Committee

2009- Graduate Program in Molecular Medicine Advisory Committee


2009-2011 Reviewing Committee, Marion Spencer Fay Award (IWHL)

2010-present Biomedical Graduate studies Education Committee (At-Large member)

2010-2014 DUCoM Tenure Committee

2011 Strategic Planning Committee for Strategic Plan 2012

2) Extramural: a) Peer Reviewer - NIH grants 2003 NIAID - Special emphasis panel “Novel HIV Therapies: Integrated Preclinical/Clinical

Program”, 2004 NIDA - Special emphasis panel ZDA MXM-M “Drug Abuse and HIV infection” 2005 NIDA - NIDA-K Training and Career Development Committee (March) - NIDA-K Training and Career Development Committee (July) - Special Emphasis Panel ZDA1 MXS-M-27 2005 NIMH - Special study section (changes to previously funded projects) (December) 2006 NIDA - NIDA-K Training and Career Development Committee (March) 2006 NIDA - NIDA-K Training and Career Development Committee (July) - Special Emphasis Panel ZDA1 MXO-O-20 2006 NIDA - NIDA-K Training and Career Development Committee (November) - Special Emphasis Panel ZDA1 MXM-20 - Special Emphasis Panel ZDA1 MXM-21 2007 NIDA - NIDA-K Training and Career Development Committee (July) - Special Emphasis Panel ZDA1 MXS-M (04) 2008 NIDA - NIDA-K Training and Career Development Committee (March) - Special Emphasis Panel ZDA1 KXH-C (18) - Special Emphasis Panel ZDA1 MXS-M (19) - HIV/AIDS Pilot Proteomics Centers ZDA1MXS-M (July) 2009 NIH - Cutting-Edge Basic Research Awards (CEBRA) (November) - The Johns Hopkins NIMH Center for Novel Therapeutic (Center Development grants June’09 – faculty reviewer) 2010 NIH - Special Emphasis Panel ZRG1 AARR-K (40) P (March) - The Johns Hopkins NIMH Center for Novel Therapeutic (Center Development grants May ’10 – faculty reviewer) NIAA (U.K.) - National Institute of Academic Anaesthesia Research Grant (November)

2011-15 NIH/NAED (NeuroAIDS and Other End-Organ Diseases) study section member


b) Peer Reviewer - Professional journals (2000-present) AIDS Research and Human Retroviruses; Biochemistry; Brain Research; Endocrine-related Cancer Research; European J. Neuroscience; Experimental Neurology; FASEB Journal; Gene; Journal of Cellular and Molecular Medicine; Journal of Cellular Physiology; Journal of Neurochemistry; Journal of Neuroscience; Journal of NeuroVirology; Journal of Neuroimmunology; Journal of NeuroImmune Pharmacology; Journal of Virology; Molecular Neurodegeneration; Molecular Pharmacology; Neurobiology of Disease; Neuropharmacology; Neuropsychopharmacology; Neuroscience; Neuroscience Letters; Oncogene; Proteins and Peptides letters.

K. Community Service 2003-present The American Cancer Society (Fund raising) The American Society for Diabetes (Fund raising) L) Educational activities 1. Courses/Clerkships/Programs a) Extramural activities (1988-2000): 1988 “Elena d’Aosta” Hospital, Nursing School, Naples, Italy Instructor, Course of Pharmacology (entire course)

1989 University of Naples, Italy, Medical School, Naples, Italy Instructor, Pharmacology Seminars (2 classes) 1990 “Elena d’Aosta” Hospital, Nursing School, Naples, Italy Instructor, Course of Pharmacology and Toxicology (entire course)

1995-2000 University of Chicago, Chicago, IL Undergraduate and graduate student “Lab advisor” (mentor: R.J. Miller, PhD) Department of Neurobiology, Pharmacology and Physiology - Umar Shakur, Undergraduate student - Arthur Simen, MD/PhD student - Charlene Chao, PhD student b) Drexel University College of Medicine (2001-present) - Taught each year - 2001-present Medical Pharmacology, 2nd year medical students Fundamental Module (2001-present) - 2 hr/y Pharmacology papers (2001-present) - 6 hr/y Musculoskeletal Module (2002-2007) - 1hr/y; (2008-present ) - 2hr/y CNS module (2002-2006) - 4hr/y MacDog lab (2002-present) - 4hr/y Cardiovascular module (2006-present) - 2hr/y 2001-present Graduate Pharmacology & Physiology (1st and 2nd year graduate students) Special Topics (2001-present) - 2hr/y Principles of neuropharmacology, behaviour and physiology (since 2007); Modulation of neurotransmission in neuroinflammation - 2hr/y


2001 Integrative Biology II, 2nd year graduate students Apoptosis and cell death – 2hr/y 2001-present Current Topics, graduate and medical students Chemokines and the CNS (Pharm&Physiol) (2001-present) - 1hr/y HIV neuropathogenesis (Micro&Immun) (2001) - 1hr Immunomodulators (Pharm&Physiol) (2002) - 2hr GTP-binding proteins (Pharm&Physiol) (2002) - 2hr Signal transduction (Cell Biology) (2002) - 2hr Cell cycle proteins and neuroAIDS (Micro&Immun) (2004) - 1hr Autoimmunity and Neuroinflammation Worskshop (DUCoM, 2004) - 1hr Neurology Ground Round (2005) - 1hr 2002-2004 Integrative Neuroscience, 2nd year graduate students Neuroimmunology – 2hr/y 2003-present Core curriculum, 1st year graduate students Signal transduction Module - 2hr/y 2005-present Advanced Neuroscience, 2nd year graduate students Cell Injury and Recovery Module - 2hr/y (2005-2008); 4hr/y since 2009 2006-present Molecular Cell Biology and Genetics Module, 2nd year graduate students Advanced Cell Biology - 2hr/y 2008-present Career Development Program – Forward Seminar Series for Postdoctoral

Fellows and graduate students; “Grant writing basics” – 2hr/y (alternate year)

2010-present Research Methodology Seminar Series (Department of Medicine) Grant Writing 101 2011-present Core curriculum, 1st year graduate students Integrated Systems module (2hr/y) 2. Advising/Mentoring/Tutoring Mentoring of graduate (and undergraduate) students toward completion of Master or PhD degree, including different research-related activities, such as: daily interactions in the lab, weekly one-on-one meetings, focus groups, and lab meetings; discussions of papers; teaching of grants/papers writing skills and presentation skills; attendance to seminars and international conferences. Past and Current Students in the lab:

2001 Danielle Resue, undergraduate student (SURF program), summer/fall 2001 (accepted by PhD program at Albany Medical College)

2001-02 Engy Hanna, MMS student (1 yr internship) - graduated summer 2002 (accepted by Robert Woods Med school and then enrolled in the NIH-sponsored research internship for MDs)

2002-03 Sanjay Maraboyna, MMS student (1 yr internship) - graduated summer 2003 (accepted by Ohio State Med School) 2003-04 Nha Huyng, MMS student (1 yr internship) - graduated summer 2004 (accepted by University of Illinois Med. School) 2003-05 My-Thao Le, undergraduate student Philadelphia Central (Gifted Student

Program), (accepted by graduate program of the University of the Sciences) 2002-06 Jeegar Patel, PhD student (Pharm&Physiol) - graduated August 2006 (recipient of an NRSA fellowship; Scientist at Abbott laboratories, Illinois) 2004-06 Anna Mullen, MS part-time student (Bioscience) relocated to Wisconsin 2004-06 Anjum Parkar, MS student (Bioengineering), graduated December 2006


2005-08 Randi Hippensteel, MS student (Neuroscience), graduated April 2008 2006-09 Rajarshi Sengupta, PhD student (Neuroscience), graduated April 2009 2006-10 Jaclyn Nicholai, PhD student (Pharm&Physiol), graduated October 2010 2008 Michael Brown, MD student (DUCoM), summer/fall 2008

2008 Avinash Vaidya, undergraduate student SURF program (Ursinus College), summer 2008; accepted into PhD program of Neuroscience at McGill Univ.

2008-present Anna L. Cook, PhD student (Neuroscience), expected grad. ‘12 2008- Jonathan Pitcher, MD/PhD student (Micro.Immun.), expected grad. ’12 2010-present Lindsay Festa, MS student (Pharmacology, Jefferson University)

2011-present Robeto Wurth, PhD student (Neuroscience, Univ. Genoa, Italy), exp. grad ‘12 (8-10 weeks lab rotations)

Angelo Lepore, PhD student (Neuroscience), summer 2001; Tina Kao, PhD student (Neuroscience), fall 2001 Nathan Dolloff, PhD student (Pharm&Physiol), spring 2003 Elaine Smolock, PhD student (Pharm&Physiol), spring 2003 Esugani Okonny, PhD student (Pharm&Physiol), fall 2005 Veronique Lepoutre, MS student (Neuroscience), fall 2005 Daphney Jean, PhD student (Neuroscience), spring 2006 Tanuja Peires, PhD student (MCBG), summer 2007 Liz Crowe, MD/PhD student (MCBG), winter/spring 2008 Nirzari Parikh, PhD student (MCBG), spring/summer 2008 Shubha Bhar, MMS student, summer 2008 Divya Sagar, PhD student (Neuroscience) spring/summer 2010 Ami Oristaglio, PhD student (Neuroscience), summer/fall 2010 Natalie Chen, MD, PhD student, summer 2011

Trainees’ Research awards: My-Thao Le (undergraduate student): Discovery Day 2003 (Honorable Mention Poster Presentation) Pennsylvania State University Scholarship 2004 Marie Curie Science Fair (1st place) 2004

Delaware Valley Science Fairs Special Award 2004, and Outstanding achievement certificate 2004

Jeegar Patel (graduate student): Discovery Day Poster award (1st place) 2005 Ben Weiss Award, 2006 NRSA-F31 fellowship, 2006 Giuseppe Bardi, PhD (postdoctoral fellow): Travel Award SNIP 2006 Saori Shimizu, MD, PhD (postdoctoral fellow): Travel Award SNIP 2006 Travel Award CROI 2007 Jackie Nicolai (graduate student): Discovery Day Poster award (3rd place) 2006 Mary Shaw Travel Award, 2007 Young Investigator Award, International Society of Neurovirology, 2007

Travel Award, Annual Meeting Society of NeuroImmune Pharmacology, SNIP 2010


Rajarshi Sengupta (graduate student): Arthur Falek Young Investigator Best Poster Award, SNIP 2007 Travel Award SNIP, 2009 Bondi Award Nomination (DUCoM 2009) Silvia Burbassi, PhD (postdoctoral fellow)

Paper selected for publication on special peer-reviewed issue of JNIP, 2007. Travel Award SNIP 2008 Arthur Falek Young Investigator Best Poster Award, SNIP 2010

Michael Brown, (MD student) Drexel Research Fellowship for medical students, 2008 Avinash Vaidya, (undergraduate student)

Summer Research Program for Undergraduate students (SURF) fellowship, 2008

Jonathan Pitcher (MD/PhD student) Graduate Research Fellow, NIMH, Philadelphia Interdisciplinary Translational Research Training Program in NeuroAIDS (2008-2010) Investigator in Training Travel Grant, International Society for Neurovirology (2009)

Travel Award, ASCI/AAP Joint Meeting (2010) Richard Crowell, Ph.D., Endowed Molecular Medicine Scholarship in Microbiology and Immunology, Drexel University (2010)

Thesis Committees member (students from other labs only)

2002-05 Angelo Lepore, PhD student (Neuroscience); graduated fall 2005 2003-07 Nathan Dolloff, PhD student (Pharm&Physiol); graduated summer 2007 2004-08 Trish Petritus, PhD student (Micro&Immun); graduated summer 2008 2005-07 Heather Painter, PhD student (MCBG); graduated winter 2007 2005-08 Nina Thakkar, PhD student (Micro&Immun); graduated spring 2008 2006-08 Heather Nyce, PhD student (Pharm&Physiol); graduated summer 2008 2006-07 Kathrina Alexaki, PhD student (Micro&Immun); graduated winter 2007 2006-10 Tricia Gearhart, PhD student (Biochem) – Chair; graduated spring 2010 2008-09 Anupam Banerjee, PhD student (Mol. Medicine)- Chair; graduated 2009

2008-10 Mike Russel, PhD student (Pharm&Physiol) – Chair; graduated spring 2010 2008-10 Whitney Jamieson, PhD student (Pharm&Physiol); graduated spring 2010 2008-10 Julia D’Ambrosio, PhD student (Pharm&Physol)- Chair; graduated spring 2010 2009- Nirzhari Parikh, PhD student (Micro&Immuno) - Chair; 2010-2011 Adriano Ferrucci, PhD student (Bioeng.) – graduation summer 2011 2010- Ludmilla Mazaleuskaya, PhD student (Pharm&Physiol) 2010- Marianne Strazza, PhD student (Micro&Immuno) - Chair 2010- Sarah Cavanaugh, PhD student (Micro&Immuno) 2010- Jessica Casciano, PhD student (MCBG) - Chair 2010- Qingxin (Cindy) Liu, PhD student (Pharm&Physol)- Chair 2010- Yun Zhang, PhD student (Pharm&Physol.) 2011- Alicia Holmgren (Micro&Immuno) M. Support Active Sponsor: NIH (2R01-DA15014-06) Project Period: 10/01/07-9/31/12 Principal Investigator: Olimpia Meucci Project Title: Role of chemokine receptors in neuronal survival


Sponsor: NIMH (5T32MH079785) (PD: Rappaport) Project Period: 7/01/08-6/31/13 (PIs-subcontract): Wigdahl/Meucci Project Title: Interdisciplinary and Translational Research Training in neuroAIDS Sponsor: US Army Public Health Command Project Period: 5/01/10-8/15/11 CTC/CHPPM (RFQ# 09-0344) Principal Investigator: Olimpia Meucci Project Title: Mechanims of action of RDX and neuronal toxicity Sponsor: Restless Leg Syndrome Foundation Project Period: 9/1/11-8/31/12 Principal Investigator: Padma Ponnuru; Mentor: Olimpia Meucci Project Title: A role for MEIS 1 in iron brain deficiency in RLS Completed Sponsor: NIH (1RO1-DA19808) Project Period: 9/20/04-9/19/09 Principal Investigator: Olimpia Meucci Project Title: Cellular and Molecular Mechanisms of HIV Neuropathology Sponsor: NIH (1R01-GM067892) Project Period: 5/1/03-4/30/08 PI: A. Fatatis; Co-I: Olimpia Meucci Project Title: Role of intracellular sphingolipids in Ca signaling Sponsor: NIH NRSA (F31-DA020234) Project Period: 5/22/06-8/30/06 Principal Investigator: Jeegar Patel (O. Meucci, mentor) Project Title: Interactions of opioid and chemokine receptors systems in neurons Sponsor: NIH (1R01-DA15014) Project Period: 9/28/01-6/30/06 Principal Investigator: Olimpia Meucci Project Title: Role of chemokine receptors in neuronal survival Sponsor: Drexel University, Synergy grant Project Period: 7/1/04-6/30-05 Project Title: “A system approach to CXCR4 receptor regulation of survival pathways in neurons and glia”. PIs: J.M. Yuan (Dept. Physics) and O. Meucci (Dept. Pharmacol&Physiol.) Sponsor: W.W. Smith Charitable Trust (A0302) Project Period: 11/01/03-1/01/04 Principal Investigator: Olimpia Meucci Project Title: Cell cycle proteins and HIV neuropathogenesis Sponsor: American Foundation for AIDS Research (2816-30-RG) Project Period: 6/01/01-12/1/02 Principal Investigator: Olimpia Meucci Project Title: Role of cell cycle proteins in HIV-Neurodegeneration


N. GRADUATE STUDENTS/POSTDOCS Graduate students trained at DUCoM (year of graduation reported) 2002 Engy Hanna, Master in Medical Science - June 2003 Sanjay Maraboyna, Master in Medical Science - June 2004 Nha Huyng, Master in Medical Science - June 2006 Jeegar Patel, PhD in Pharmacology and Physiology - August 2006 Anjum Parkar, Master in Bioengineering - December 2008 Randi Hippensteel, Master in Neuroscience - April 2009 Rajarshi Sengupta, PhD in Neuroscience – April 2010 Jaclyn Nicolai, PhD in Pharmacology and Physiology - October Past and current postdoctoral fellows and postgraduate medical trainees

Padma Ponnuru, PhD, July 2011 – present. Project: “Iron metabolism in the brain”

Saori Shimizu, MD, PhD, February 2004 – June 2011. Projects: “Cell cycle proteins and HIV neuropathogenesis”; “Roles of CXCR7 in differentiate neurons”

Silvia Burbassi, PhD, April 2006 – Sept 2010. Project: “Chemokine-neuropeptide

interactions”

M.Z. Khan, PhD, July 2001 – January 2010. Project: “Chemokine receptors and neuronal survival”

Renato Brandimarti, PhD, Visiting Scientist (summers of 2002, 2003, 2004, 2005, 2007).

Project “Effects of viral proteins on neuronal cell cycle proteins”.

Giuseppe Bardi, PhD, January 2005 – June 2006. Project: “Regulation of chemokine receptors function in the CNS”.

Jose Joaquin Merino, PhD, Post-doctoral fellow, spring 2002. Project: “Expression of

neural adhesion molecules in neurons: effects of chemokines”.


O) BIBLIOGRAPHY (ALL PEER-REVIEWED) 1. REGULAR PAPERS:

1) Schettini G., Florio T., Meucci O., Landolfi E., Cronin M.J., MacLeod R.M., "Calmodulin modulates prolactin secretion by anterior pituitary cells in vitro: studies with calmodulin containing liposomes", Life Science 41:2437-2444, (1987).

2) Schettini G., Florio T., Meucci O., Landolfi E., Lombardi G., Marino A., "Somatostatin inhibition of anterior pituitary adenylate cyclase activity: different sensitivity between male and female rats", Brain Research 439:322-329, (1988).

3) Schettini G., Meucci O., Florio T., Grimaldi M., Landolfi, Magri G., Yasumoto T., "Pertussis toxin pretreatment abolishes dihydropyridine inhibition of calcium flux in the 235-1 pituitary cell line", Biochemical and Biophysical Research Communications 151:361-369 (1988).

4) Schettini G., Florio T., Magri G., Grimaldi M., Meucci O., Landolfi E., Marino A., "Somatostatin and SMS 201-995 reversal of the impairment of cognitive functions induced by cystemanine depletion of brain somatostatin" European Journal of Pharmacology 151:399-407 (1988).

5) Schettini G., Florio T., Meucci O., Scala G., Landolfi E., Grimaldi M., "Effect of IL1 beta on transucing mechanisms in 235-1 clonal pituitary cells. Part 1: modulation of adenylate cyclase activity", Biochemical Biophysical Research Communication 155:1089-1096, (1988).

6) Schettini G., Meucci O., Florio T., Scala G., Landolfi E., Grimaldi M., "Effect of IL1 beta on transucing mechanisms in 235-1 clonal pituitary cells. Part 2: modulation of calcium fluxes", Biochemical Biophysial Research Communications 155:1097-1104, (1988).

7) Schettini G., Florio T., Meucci O., Landolfi E., Grimaldi M., Ventra C., Marino A., "Somatostatin inhibition of adenylate cyclase activity in different brain areas", Brain Research 492:65-72 (1989).

8) Schettini G., Landolfi E., Grimaldi M., Meucci O., Postiglione A., Florio T., Ventra C. Interleukin 1 beta inhibition of TRH-stimulated prolactin secretion and phoshoinositides metabolism. Biochemical Biophysical Research Communications 165 (1): 496-505 (1989).

9) Schettini G., Florio T., Meucci O., Landolfi E., Grimaldi M., Scala G., Marino A., "Interleukin 1 modulation of prolactin secretion from rat anterior pituitary cells: involvment of adenylate cyclase activity and calcium mobilization", Endocrinology, 126:1435-1441 (1990).

10) Bergamaschi S., Trabucchi M., Battaini F., Parenti M., Schettini G., Meucci O., Govoni S. "Modulation of dihydropyridine-sensitive calcium channels: a role for G proteins" European Neurology 30 (suppl 2):16-20 (1990).

11) Marino A., Florio T., Meucci O., Landolfi E., Grimaldi M., Ventra C., Schettini G., "Fipexide improvement of cognitive functions in rat: behavioural and neurochemical studies", Pharmacological Research 22,(Suppl.2):179-187 (1990).

12) Schettini G., Landolfi E., Meucci O., Florio T., Grimaldi M., Ventra C. and Marino A., "Adenosine and its analogue N6phenylisopropyladenosine (PIA) modulate anterior pituitary adenylate cyclase activity and prolactin secretion." The Journal of Molecular Endocrinology, 5:69-76 (1990)

13) Schettini G., Meucci O., Grimaldi M., Florio T., Landolfi E., Scorziello A., Ventra C., "Dihydropiridine modulation of K+-activated calcium channels in PC12 cells: effect of pertussis toxin pretreatment, The Journal of Neurochemistry, 56:805-811 (1991).

14) Schettini G., Grimaldi M., Landolfi E., Meucci O., Ventra C., Florio T., Scorziello A., Marino A., Role of Interleukin-6 in the neuroendocrine system, Acta Neurologica 13(4): 361-367 (1991).

15) Meucci O., Grimaldi M., Scorziello A., Govoni S., Bergamaschi S., Yasumoto T., Schettini


G., Maitotoxin-induced intracellular calcium rise in PC12: involvement of dihydropiridine-sensitive and omega-conotoxin-sensitive calcium channels and phosphoinositides breakdown, The Journal of Neurochemistry 59:679-688 (1992).

16) Schettini G., Ventra C., Florio T., Grimaldi M., Meucci O. and A. Marino, Modulation by GTP of basal and agonist-stimulated striatal adenylate cyclase activity following chronic blockade of D-1 and D-2 dopamine receptors: involvement of G-proteins in the development of dopamine receptor supersensitivity, The Journal of Neurochemistry 59:1667-1674 (1992).

17) Schettini G., Ventra C., Florio T., Meucci O., Grimaldi M., Scorziello A., Talia S., Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition enhancing drug, on behavioral and biochemical parameters in young and aged rats, Pharmacological Biochemical Behaviour 43:139-151 (1992).

18) Grimaldi M., Meucci O., Scorziello A., Florio T., Ventra C., and Schettini G. "Interleukin-6 modulation of second messengers response in anterior pituitary cells” Life Sciences 51:1243-1248 (1992).

19) Meucci O., Landolfi E., Scorziello A., Grimaldi M., Ventra C., Florio T., Avallone A. and Schettini G. "Dopamine and somatostatin inhibition of prolactin secretion from MMQ pituitary cells: role of ATP-sensitive potassium channels" Endocrinology 131:1942-1947 (1992).

20) Santangelo F., Grimaldi M., Landolfi E., Ventra C., Belfiore A., Meucci O., Santillo M., Mondola P. and Schettini G. "Effect of calf thymus protein on prolactin release and secon messenger systems in rat pituitary cells" Progress in NeuroEndocrinImmunology 5:172-178 (1992).

21) Meucci O., Berlingieri M.T., Fusco A., Scorziello A., Santoro M., Grieco M., Grimaldi M., and Schettini G., Norepinephrine and thyrotropin stimulation of [Ca++]i in PC Cl3 a rat thyroid epithelial cell line: effect of transformation by E1A gene of adenovirus and polyomavirus middle-T antigen gene. Life Sciences 52:891-899 (1993).

22) Florio T., Meucci O., Grimaldi M., Ventra C., Cocozza E., Avallone A., Postiglione A., Marino A., and Schettini G. "Effect of acetyl-L-carnitine treatment on brain adenylate cyclase activity in young and aged rats" European Neuropsycopharmacology, 3:95-101 (1993)

23) Scorziello A., Landolfi E., Grimaldi M., Meucci O., Ventra C., Florio T., Avallone A., Postiglione A. and Schettini G., Direct effect of adenosine on prolactin secretion at the level of the single rat lactotroph: involvement of pertussis toxin-sensitive and insensitive transducing mechanisms. The Journal of Molecular Endocrinology 11:325-334 (1993).

24) Meucci O., Scorziello A., Avallone A., Ventra C., Grimaldi M., Berlingieri M.T., Fusco A. and Schettini G. Alpha 1A and alpha 1B-adrenergic receptors mediate the effect of norepinephrine on cytosolic calcium levels in rat PC Cl3 thyroid cells. Thyrotropin modulation of alpha 1B-linked response via a cAMP-protein kinase A-dependent pathway. Endocrinology 134:424-431 (1994).

25) Meucci O., Scorziello A., Avallone A., Florio T., and Schettini G., Alpha 1B, but not alpha 1A, adrenoreceptor activates calcium influx through the stimulation of a tyrosine kinase/phosphotyrosine phosphatase pathway, following noradrenaline-induced emptying of IP3 sensitive-calcium stores, in PC Cl3 rat thyroid cell line. Biochemical Biophysical Research Communications 209:630-638 (1995).

26) Ventra C, Meucci O, Grimaldi M, Scorziello A, Porcellini A, Schettini G. Absence of D2S dopamine receptor in the prolactin-secreting MMQ pituitary clone: characterization of a wild D2L receptor coupled to native transduction mechanisms. Journal of Molecular Endocrinology 14(3):375-89 (1995)

27) Galli C., Meucci O., Scorziello A., Werge T.M., Calissano P., and Schettini G., Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct


mechanisms of action: the involvement of intracellular calcium and RNA synthesis. The Journal of Neuroscience 15 (2):1172-1179 (1995).

28) Meucci O., Fatatis A., Holzwarth J. and Miller R.J., Developmental regulation of the toxin sensitivity of Ca2+ permeable AMPA receptors in cortical glia. The Journal of Neuroscience 16:519-530 (1996).

30) Scorziello A., Meucci O., Florio T., Fattore M., Forloni G., Salmona M., and Schettini G., β25-35 alters calcium hoemostasis and induces neurotoxicity in cerebellar granule cells. The Journal of Neurochemistry 66:1995-2003 (1996).

29) Meucci O. and Miller R.J. gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective action of TGF-β1. The Journal of Neuroscience 16:4080-4088 (1996).

31) Scorziello A, Meucci O, Calvani M, Schettini G. Acetyl-L-carnitine arginine amide prevents beta 25-35-induced neurotoxicity in cerebellar granule cells. Neurochemical Research 22:257-65 (1997).

32) Meucci O. and Miller R.J. Dissociation between Joro spider toxin sensitivity of recombinant AMPA receptors and their ability to increase intracellular calcium. Neuropharmacology 37:1431-1443 (1998).

33) Meucci O., Fatatis A., Simen A.A., Bushell T.J. Gray P.W. and Miller R.J. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proceedings in the National Academy of Science (PNAS), USA. 95:14500-505 (1998).

34) Miller R.J. and Meucci O. AIDS and the brain: is there a chemokine connection? Trends in Neuroscience 22:471-479 (1999). 35) Meucci O., Fatatis A., Simen A.A., and Miller R.J. Expression of CX3CR1 chemokine

receptors on neurons and their role in neuronal survival. Proceedings in the National Academy of Science, USA 97:8075-8080 (2000)

36) Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P, D'Adamio L. The γ-secretase-generated intracellular domain of β-amyloid precursor protein binds Numb and inhibits Notch signaling. Proceedings in the National Academy of Science (PNAS), USA 99:7102-07 (2002)

37) Khan M.Z., Brandimarti R., Musser B.J., Resue D.M., Fatatis A., and Meucci O. The chemokine receptor CXCR4 regulates cell cycle proteins in neurons. Journal of NeuroVirology 9:300-314 (2003)

38) Brandimarti R., Khan M.Z., Fatatis A. and Meucci O. “Regulation of cell cycle proteins by chemokine receptors: a novel pathway in HIV neuropathogenesis?” Journal of NeuroVirology 10: 1-5 (2004)

39) Shulby S.A, Dolloff N.G, Stearns M.E., Meucci O., and Fatatis A “CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration and survival of human prostate cancer cells. Cancer Research, 64:4693-4698 (2004).

40) Khan M.Z., Brandimarti R., Patel J.P., Huynh N., Wang J., Huang Z., Fatatis A., and Meucci O. Apoptotic and anti-apoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis. AIDS Research and Human Retroviruses 10:1063-1071, (2004)

41) Khan M.Z, Shimizu S., Patel J., Nelson A., Le M-T., Mullen-Przeworski A., Brandimarti R., Fatatis A., and Meucci O. “Regulation of neuronal p53 activity by CXCR4”, Molecular and Cellular Neuroscience 30(1):58-66, (2005)

42) Dolloff N.G, Shulby S.S., Nelson A.V, Stearns M.E., Johannes G.J, Thomas J.D., Meucci O. and Fatatis A. “Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha Platelet Derived Growth Factor Receptor”, Oncogene, (Nature Publishing Group), 24: 6848-54 (2005).

43) Bardi G, Sengupta G, Khan MZ, Patel JP and Meucci O., HIV gp120-induced apoptosis of human neuroblastoma cells in the absence of CXCR4 internalization Journal of NeuroVirology 12:211-218, (2006).


44) Patel P., Sengupta R., Bardi G., Khan MZ., Mullen-Przeworski A., and Meucci O., “Modulation of neuronal CXCR4 by the µ-opioid agonist DAMGO” , Journal of NeuroVirology, 12: 492-500 (2006).

45) Shimizu S., Khan MZK, Hippensteel R., Parkar A., Raghupathi R., and Meucci O. “Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology”, Neurobiology of Disease, 25: 17-26 (2007).

46) Jain P., Ahuja J., Khan ZK., Shimizu S., Meucci O., Jennings SR., and Wigdahl B “Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1”, Journal of Leukocyte Biology 82:44-56 (2007)

47) Burbassi, S. Aloyo V, Chaijale N., Simansky K., and Meucci O. GTPγS incorporation in the rat brain: a study on µ-opioid receptors and CXCR4, Journal of NeuroImmune Pharmacology (2008) 3(1):26-34.

48) Jamieson W., Shimizu S., D’Ambrosio J., Meucci O., and Fatatis A., CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/Fractalkine in the bone marrow: potential role in prostate cancer bone tropism, Cancer Research (2008) 68(6):1715-22.

49) Khan M.Z., Brandimarti R., Shimizu S., Nicolai J., Crowe E., and Meucci O, The chemokine CXCL12 promotes survival of post-mitotic neurons by regulating Rb protein. Cell Death & Differentiation (Nature Publishing Group) (2008) 15:1663-1672.

50) Sengupta R., Burbassi S., Shimizu S., Cappello S., Vallee R., Rubin J., and Meucci O. Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons. The Journal of Neuroscience (2009) 29:2534-44.

51) Busillo J., Armando S, Sengupta R, Meucci O., Bouvier M and Benovic J. Specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in defferential modulation of CXCR4 signaling”. Journal of Biological Chemistry (2010) 285:7805-17

52) Cook A., Hippensteel R., Shimizu S, Nicolai J. Fatatis A. and Meucci O., Interactions between chemokines: regulation of fractalkine/CX3CL1 homeostasis by SDF/CXCL12 in cortical neurons" Journal of Biological Chemistry (2010) 285:10563-71.

53) Nicolai J., Burbassi S., Rubin J., and Meucci O. CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a Histone deacetylase-dependent pathway contributing to neuronal survival" Cell Death and Disease (Nature Publishing Group) (2010) 1, e33; doi:10.1038/cddis.2010.10.

54) Pitcher J., Shimizu S., Burbassi S., and Meucci O., Disruption of neuronal CXCR4 function by opioids: preliminary evidence of Ferritin Heavy Chain as potential etiological agent in neuroAIDS” Journal of Neuroimmunology (2010) 224:66-71.

55) Khan MZ., Vaidya A., and Meucci O. CXCL12-mediated regulation of ANP32A/Lanp, a component of the Inhibitor of Histone Acetyl Transferase (INHAT) complex, in cortical neurons The Journal of Neuroimmune Pharmacology 2011 Mar;6(1):163-70, Epub ahead of print July 9, 2010. PMID: 20617464.

56) Burbassi S., Sengupta, and Meucci O. Alterations of CXCR4 function in the brain of MOR-deficient mice. European Journal of Neuroscience (2010), 32(8):1278-88. doi: 10.1111/j.1460-9568.2010.07402.x PMID: 20880358

57) Abt Cook A. and Meucci O. Regulation of ferritin heavy chain a new player in opiate-induced chemokine dysfuction The Journal of Neuroimmune Pharmacology 2011; DOI 10.007/s11481-011-9278-3

58) Shimizu S., Brown M., Sengupta R., Penfold M., and Meucci O. CXCR7 protein expression in human adult brain and differentiated neurons. PloS ONE 2011 (published 5/31/2011)

59) Shimizu S., Abt C.A., and Meucci O. Bilaminar co-culture of primary rat cortical neurons


and glia. Journal of Visualized Experiments (JoVE), in production (July 2011) Manuscripts in preparation:

Nicolai J., Sagar D., and Meucci O. Regulation of neuronal HDACs and dendritic spine density by CXCL12.

Nicolai J., Shimizu S., Khan MZ. and Meucci O. Inhibition of the E2F1 target cdc2 prevents HIV gp120-induced neurotoxicity

2. BOOK CHAPTERS & INVITED REVIEWS/ARTICLES:

1. Schettini G., Fariello C, Miletto P., Ciampanelli D., Florio T., Meucci O., Landolfi E., Merola B., Lombardi G., Cronin M.J., MacLeod R.M., "GRF stimulation of GH release in vitro: relation to cAMP and Ca++ Calmodulin", In "Proceedings of the International Congress of Endocrinology 1985", p. 143-146, (1986).

2. Schettini G., Cronin M.J., Florio T., Ciampanelli D., Landolfi E., Meucci O., MacLeod R.M., "Post-receptors mechanism mediating inhibition of prolactin secretion", In "Modulation of central and peripheral transmitter functions", G.Biggio, P.F.Spano, G.Toffano, G.L.Gessa eds., Fidia Research Series, Symposia in Neuroscience III, Liviana Press, Padova p. 359-365, (1986).

3. Schettini G., Florio T., Meucci O., Landolfi E., Grimaldi, Marino A., "Somatostatinergic and dopaminergic modulation of cognitive functions: behavioural and neurochemical studies", In "Current problems in senile dementias", A.Agnoli, J.Cohn, N.Lassen, R.Mayeux, John Libbey Eurotext, London Paris, p. 345-349, (1988).

4. Florio T., Magri G., Landolfi E., Meucci O., Grimaldi M., Schettini G., Marino A., "Depletion of brain somatostatin (SRIF) by cysteamine (CSH) induces impairment of cognitive functions in rat: reversal by exogenous administration of SRIF or its analogue SMS 201-995", Pharmacological Research Communications 20:241-242 (1988).

5. Landolfi E., Florio T., Meucci O., Grimaldi M., Magri G., Leong D.A. and Schettini G., "Steroid modulation of prolactin release from single lactotropes in male and female rats studied by the reverse hemolytic plaque assay", Pharmacological Research Communications 20:1075-1076 (1988).

6. Meucci O., Florio T., Grimaldi M., Landolfi E., Magri G. and Schettini G., "Role of G-proteins in mediating dihydropiridine receptor coupling with voltage sensitive calcium channels", Pharmacological Research Communications 20:1083-1084 (1988).

7. Schettini G., Florio T., Meucci O., Landolfi E., Grimaldi G., Ventra C., Scorziello A. and Marino A., "Il ruolo della trasmissione somatostatinergica e dopaminergica nella modulazione delle funzioni cognitive", In "Progressi in psichiatria", P.Pancheri, G.C.Reda, CIC Edizioni Internazionali, vol I p. 213-220, (1989).

8. Schettini G., Florio T., Meucci O., Landolfi E., Grimaldi M., Magri G., Merola B., Lombardi G., "Intracellular mechanism in GH control", In "Perspective in Neuroendocrinology” Vol. 6, R.M.MacLeod, E.E.Muller eds., p. 189-198 (1989).

9. Meucci O., Grimaldi M., Florio T., Landolfi E., Scorziello A., Ventra C., Marino A. and Schettini G., "Dihydropiridine inhibition of K+ and maitotoxin stimulated calcium fluxes in PC12 cells: effect of pertussis toxin", Pharmacol. Research, 21 (Suppl.1):1-2 (1989).

10. Landolfi E., Meucci O., Florio T., Grimaldi M., Marino A., Schettini G., "Anterior pituitary adenosine receptors, coupled to adenylate cyclase, modulate prolactin release", Pharmacological Research, 21 (Suppl.1):5-6 (1989).

11. Florio T., Meucci O., Landolfi E., Grimaldi M., Ventra C., Scorziello A., Marino A. and Schettini G., "Interleukin I modulation of anterior pituitary function: effect on hormone release and second messenger systems", Pharmacological Research, 21 (Suppl.1):35-36 (1989).


12. Meucci O., Grimaldi M., Florio T., Landolfi E., Ventra C., Scorziello A., Marino A., Schettini G. "Cytosolic calcium rise induced by maitotoxin in PC12 cells: effect of omega-conotoxin (GVIA), Pharmacological Research, 22:(suppl.1)(1990).

13. Schettini G., Florio T., Ventra C., Grimaldi M., Meucci O., Landolfi E., "Effetto del trattamento in vivo con alfa GFC (colina alfoscerato) sull'attività dei sistemi di trasduzione a livello cerebrale" In "Le basi razionali della terapia" , P.F. Spano, M.Trabucchi, Ed. PICCIN, Padova, Vol XX, N 3, Suppl 1, pp23-30 (1990).

14. Schettini G., Florio T., Meucci O., Landolfi E., Grimaldi M., Lombardi G., Marino A., "Interleukin 1 modulation of anterior pituitary function: effect on hormone secretion and transducing mechanisms", In Recent Advances in basic and clinical neuroendocrinology, Elsevier Science Publishers, FF Casanueva, C Dieguez Eds p. 141-150 (1990) .

15. Schettini G., Florio T., Meucci O., Landolfi E., Grimaldi M., Ventra C., Marino A., "Interleukin-1 modulation of anterior pituitary function effects on prolactin release and postreceptor trasducing mechanisms", In "Annals of New York Accademy of Sciences", p. 155-157 (1990).

16. Grimaldi M., Landolfi E., Meucci O., Florio T., Ventra C., Schetttini G., Marino A. "Interleukin 1 beta modulation of TRH-stimulated prolactin secretion and inositol phosphate production" Pharmacological Research, 22 (suppl.1)(1990).

17. Meucci O., Landolfi E., Grimaldi M., Florio T. and Schettini IL6 modulation of prolactin release and intracellular transducing mechanisms in rat anterior pituitary cells". Pharmacological Research 22 (Suppl.2):329 (1990).

18. Tran P.B., Meucci O. and Miller R.J. HIV-1 and chemokines in the brain: location, location-location? Molecular Psychiatry, 4:203-205, (1999).

19. Khan MZ., Shimizu S., and Meucci O. “E2F proteins in the CNS: role of E2F1 in neuroAIDS and other neuroinflammatory/ neurodegenerative disorders”, in Control of cellular physiology by transcription factors E2F, Research Signpost ; Edited by Kenichi Yoshida, (2008)

20. Sengupta R. and Meucci O. “Regulation of neuronal chemokine receptors by opiates”, in Chemokine receptors and neuroAIDS: beyond co-receptor function and links to other neuropathologies”, Springer; Edited by O. Meucci, (2009)

21. Nicolai J. and Meucci O. “Homeostatic role of chemokines in the central nervous system: CXCL12 effects on developing and mature neurons”; in Chemokines: Types, Functions, and Structural Characteristics; Novascience Editions, (2010)

22. Barnejee A., Strazza M., Wigdahl B., Meucci O and Nonnemacher M.R. Role of the mu-opioids as cofactors in HIV disease progression and neuropathogensis. The Journal of Neurovirology (invited review, 2011)

PRESENTATIONS - BY INVITATION –

2001 Dept. of Microbiology & Immunology Seminars Series, MCPH University, Philadelphia; November 11, "Cellular and Molecular mechanisms of HIV-1 induced neuropathogenesis”.

2002 Center for Neurovirology and Cancer Biology, Temple University, Philadelphia; February 21, "Cellular and Molecular mechanisms of HIV-1 induced neuropathogenesis".

2002 “Viral and Host Genetic Factors Regulating HIV/CNS Disease” Meeting sponsored by NIH-NIMH, Washington D.C.; November 21, “Effect of chemokine receptors on cell cycle proteins: a novel pathway in HIV dementia?”

2002 4th Intl. Meeting of the Society of Neurovirology and 10th Conference on Neuroscience of


HIV Infection, Dusseldorf, Germany; June 19-23, “Chemokine receptors and HIV-induced neurodegeneration: are cell cycle proteins involved?”

2003 Department of Neuroscience, Georgetown University Medical Center, Washington D.C.; February 10, “Physiogical and pathological roles of chemokine in the CNS: cell cycle proteins and HIV neuropathogenesis”

2003 A.J. Drexel. Institute of Basic and Applied Protein Science 1st Annual Retreat, Drexel University, Philadelphia; June 9, “Chemokine receptors and HIV neuropathogenesis”

2003 A.J. Drexel. Institute of Basic and Applied Protein Science Neuro/Proteomics Workshop, Drexel University, Philadelphia; November 20, “Infection and Inflammation”.

2003 Department of Psychiatry, Yale University, New Haven, CT; December 1,“Chemokine receptors and HIV neuropathogenesis”

2004 Dept. of Microbiology & Immunology Seminars Series, Drexel University, Philadelphia; February 19, "Cell cycle proteins and chemokine receptors in the CNS”.

2004 Society on NeuroImmune Pharmacology, 10th Annual Conference “Neuroimmune Circuits and Infectious disease”, Santa Fe, New Mexico; March 26, “Chemokine receptors and cell cycle proteins in neuroAIDS.”

2004 Workshop on Neuronal Cell Differentiation and Development, Temple University, Philadelphia; May 19, "Effects of chemokines on cell cycle proteins involved in neuronal survival and differentiation".

2004 Autoimmunity and Neuroinflammation Workshop, Drexel University College of Medicine, Philadelphia; August 26-27, “Role of cell cycle proteins in neuronal survival and neuroAIDS”

2005 Neurology Ground Round, Hahnemann Hospital, Philadelphia; March 18, "Chemokine receptors in the CNS: from neuronal survival to neuroAIDS".

2006 Center for Substance of Abuse Research, Department of Pharmacology, Temple University, Philadelphia; March 7, “Chemokine-opioid interactions in the CNS”.

2006 Department of Neurology, University of Pennsylvania, Philadelphia, Neurovirology Training Group Seminars; October 26, “Chemokine receptors and HIV neuropathology: focus on neuronal CXCR4 and its regulation by opioids”.

2007 8th Intl. Meeting of the Society of Neurovirology, San Diego October 29 – November 2; Breakout Session: NeuroAIDS - Emerging Issues in Neuropathogenesis and Therapeutic Targets: From Preclinical Models to Clinical Studies; “Alteration of neuronal CXCR4 function by in vivo/in vitro opiate treatments and its role in neuronal survival and HIV neuropathogenesis.”

2008 Departments of Pediatrics, Division of Reumathology, Joseph Stokes Jr. Research Institute, The Children Hospital of Philadelphia; Vaccine and Immune Therapies Seminar Series, January 9th, “Alteration of neuronal CXCR4 functions by opioids and implications for neuroAIDS”.

2008 Department of Neuroscience, Temple University, Philadelphia; January 30th, “Regulation of CXCR4 function by opiates and its role in neuronal survival and neuropathogenesis”.

2008 Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Advanced Topics in Virology & Neurology, May 8th “Mechanism of HIV neuropathogenesis”


2008 Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, May 27th, “Regulation and function of neuronal CXCR4”.

2008 Department of Neurology, Neuroimmunology Group, Johns Hopkins University, Baltimore, September 16 – “Regulation of neuronal CXCR4: focus on HIV neuropathology and drug abuse”.

2008 1st Indo-US Conference on Translational Medicine and Infectious Disease, National Institute of Immunology, New Delhi, India, November, 17-20, 2008. “Drug abuse and neuroAIDS” (cancelled)

2009 Society on NeuroImmune Pharmacology, 15th Annual Conference, Wuhan, China, April 21-24, 2009; Symposium IV; “Novel mechanisms in neurotoxicity and neuroAIDS”.

2009 2nd International Workshop Chemokines and Chemokine Receptors in the CNS, Rome, Italy October 23-25. “Alteration of neuronal CXCR4 function by opioids: Role of Ferritin Heavy Chain and implications for neuroAIDS”

2010 10th International Symposium on NeuroVirology & 2010 Conference on HIV in the Nervous System, Milan, Italy October 12-16. “Opiates and CXCR4: New effectors and regulatory pathways relevant to HIV neuropathology”

- OTHER POSTERS/TALKS – (International meetings only - also published as abstracts)

1987 EMBO Intensive Lecture Course "Transmembrane signalling from structure to function of channels and receptors": Role of G proteins in mediating dihydropiridines receptor coupling with voltage sensitive calcium channels. September 7-19, Pavia, Italy (Oral presentation).

1989 4th International Symposium on "Calcium antagonists: pharmacology and clinical research" "Dihydropiridine inhibition of K+ and maitotoxin stimulated calcium fluxes in PC12 cells: effect of pertussis toxin" May 25-27, Firenze, Italy (Oral presentation).

1989 IV Meeting of the European Neuroendocrine Association, "Effect of dihydropiridines on K+ and maitotoxin induced rise of intracellular calcium levels in PC12 cells: studies after pertussis toxin pretreatment", June 28-30, Santiago De Compostela, Spain (Poster) .

1989 12th Annual Meeting of the European Neuroscience Association, "Effect of pertussis toxin pretreatment on dihydropiridine reduction of K+ and maitotoxin induced cytosolic calcium rise in PC12 cells", September 3-7, Torino, Italy (Poster).

1990 2nd Joint Meeting of Italian and Hungarian Pharmacological Societies. "How does maitotoxin increase cytosolic calcium levels?" May 14-15, Budapest, Hungary (Poster).

1990 XIth International Congress of Pharmacology "Voltage activated calcium channels in PC12 cells. Effect of maitotoxin and omega-conotoxin", Luglio 1-6, 1990, Amsterdam, Holland (Poster).

1991 5th International Symposium on Calcium antagonists: Pharmacology and Clinical Research "Effect of different calcium-antagonists on maitotoxin-induced cytosolic calcium increase, membrane depolarization and inositol phosphate production in PC12 cells" September 25-28, Houston, Texas (Oral presentation).

1991 21st Annual Congress of The Society for Neuroscience, "Involvement of ATP-sensitive K + channels in somatostatin-induced cytosolic calcium reduction, membrane


hyperpolarization but not inhibition of adenylate cyclase activity in MMQ cells" November 10-15, New Orleans Lousiana (Poster).

1993 23rd Annual Meeting of the Society for Neuroscience, "TSH regulates alpha 1 adrenergic receptors which mediate [Ca2+]i rise in PC Cl3, via a cAMP-dependent pathway" November 7-12, Washington, D.C. (Poster).

1993 23rd Annual Meeting of the Society for Neuroscience, " Intracellular calcium as a second messenger in mature cerebellar granule cells undergoing apoptosis" November 7-12, Washington, D.C.) (Poster).

1994 24th Annual Meeting of the Society for Neuroscience, “β 25-35 amyloid fragment destabilizes [Ca2+]i homeostasis and induces neurotoxicity in cerebellar granule cells” November 13-18, Miami Beach, Florida (Poster).

1994 24th Annual Meeting of the Society for Neuroscience, “TK/PTP modulation of [Ca2+]i rise induced by noradrenaline in PC Cl3 rat thyroid cells” November 13-18 Miami Beach, Florida (Poster).

1995 25th Annual Meeting of the Society for Neuroscience, “Enanchement of EAA- neurotoxicity by 25-35 β-amyloid in cerebellar granule cells” Novembre 11-16, San Diego, California (Poster).

1995 25th Annual Meeting of the Society for Neuroscience, “Differentiation of glial O-2A progenitors reduces the sensitivity of AMPA receptors to block by Joro spider toxin” November 11-16, San Diego, California (Oral presentation).

1996 26th Annual Meeting of the Society for Neuroscience, “The sensitivity to Joro spider toxin of recombinant AMPA receptors” November 16-21, Washington, D.C. (Poster).

1996 26th Annual Meeting of the Society for Neuroscience, “Calcineurin inhibitors block apoptotic signal trasduction in cerebellar granule cells” November 16-21, Washington, D.C. (Poster).

1998 28th Annual Meeting of the Society for Neuroscience, “Effect of chemokines on hippocampal neuronal signaling and gp120 neurotoxicity”, November 7-12, Los Angeles, CA (Poster).

1999 HIV and the Nervous System: Emerging Issues (sponsored by NIMH and NINDS) “Chemokine receptors on hippocampal neurons are coupled to multiple intracellular pathways and regulate gp120 neurotoxicity “April 14-16, Washington, D.C. (Poster)

1999 29th Annual Meeting of the Society for Neuroscience, “Intracellular pathways mediating the neuroprotective effect of the chemokine fractalkine: a role for Akt protein kinase ”, October 23-28, Miami Beach , FL (Poster).

1999 29th Annual Meeting of the Society for Neuroscience, “Effect of chemokines and the HIV-1 protein gp120 on NFkB activation in hippocampal neurons” October 23-28, Miami Beach , FL (Poster).

2001 31th Annual Meeting of the Society for Neuroscience, “Different coupling of chemokine receptors to survival pathways”, November 10-15, San Diego, CA (Poster)

2002 4th Annual Meeting of the Society of Neurovirology and 10th Conference on Neuroscience of HIV Infection, “Apoptotic and anti-apoptotic pathways coupled to chemokine receptors” June 19-23, Dusseldorf, Germany (Poster)

2002 32th Annual Meeting of the Society for Neuroscience, November 2-7, Orlando, Fl. “Chemokines regulate cell cycle proteins in neurons” (Poster)


2003 “5th International Symposium of NeuroVirology/HIV Molecular and Clinical Neuroscience Workshop” September 2-6, Baltimore, MD, Regulation of Cell Cycle Proteins by Chemokine Receptors: Effect of gp120 and SDF1-alpha on p53 and MDM2.

2003 33th Annual Meeting of the Society for Neuroscience, November 8-12, New Orleans, LA. “A comparative study of cell signaling pathways regulated by the chemokine receptor CXCR4 in human astrocytes.” (Poster)

2004 10th Annual Meeting on Neuroimmune Circuits and Infectious Diseases, March 24-28, Santa Fe, New Mexico, “Expression and activation of opioid receptors in neural cells” (Poster)

2004 Patel J.P, Khan M.Z., Shimizu S. and Meucci O., “Opioid and Chemokine Receptors: Interactions in NeuroAIDS”. 6th International Symposium on Neurovirology & HIV Neuroprotection Workshop, September 2004, Sardinia Italy

2004 Brandimarti R., M.Z. Khan, J.P. Patel, S. Shimizu, and O. Meucci., “Molecular mechanisms involved in the regulation of cell cycle proteins by CXCR4: a study with EGFP-Rb fusion proteins”. 6th International Symposium on Neurovirology & HIV Neuroprotection Workshop, September 2004, Sardinia Italy

2004 Shimizu S., Khan M.Z., Raghupathi R. and Meucci O., “E2F1 target proteins and HIV neuropathology”. 34th Annual Meeting of the Society for Neuroscience, San Diego, CA, October 2004.

2004 Khan M.K., Brandimarti R., Patel J.P., Fatatis A. and Meucci O., “The chemokine receptor CXCR4 regulates p53 in neurons”. 34th Annual Meeting of the Society for Neuroscience, San Diego, CA, October 2004.

2004 Patel J.P., Khan M.Z., and Meucci O., “Interactions of opioid and chemokine receptors in neuronal cells”. 34th Annual Meeting of the Society for Neuroscience, San Diego, CA, October 2004.

2005 J.P. Patel, G. Bardi, M.Z. Khan, A. Mullen and O. Meucci. “µ-opioid agonists down-regulate neuronal responses to the chemokine SDF-1α" 35th Annual Meeting of the Society for Neuroscience, Washington DC, November 12-16 2005 .

2005 G. Bardi , J.P. Patel, , S. Shimizu, and O. Meucci “The µ-opioid receptor agonist DAMGO impairs SDF-induced neuronal migration without altering CXCR4 expression” 35th Annual Meeting of the Society for Neuroscience, Washington DC, November 12-16 2005 .

2006 Bardi G., Patel. JP, Sengupta R., Khan MZ, and Meucci O. “The HIV gp120 protein does not internalize CXCR4 in SH-SY5Y cells”12th SNIP conference, Santa Fe New Mexico, April 5-9

2006 Shimizu S., Khan MZ., Parkar A. and Meucci O. “Role of E2F1-dependent apoptotic targets in HIV neuropathology” 12th SNIP conference, Santa Fe New Mexico, April 5-9

2006 Bardi G., Patel J., Sengupta R., Khan MZ., and Meucci O “ HIV gp120-induced apoptosis of human neuroblastoma cells in the absence of CXCR4 internalization”, 7th International Symposium on NeuroVirology, Philadelphia, May 31-June 3

2006 Patel J., Bardi G., Khan MZ., Sengupta R., Mullen-Przeworski A., and Meucci O. “ Opioid-chemokine interactions in the CNS: regulation of neuronal CXCR4 by mu-opioid peptides” 7th International Symposium on NeuroVirology, Philadelphia, May 31-June 3

2006 Jain P., Ahuja J., Shimizu S., Meucci O., Khan ZK., Wigdahl B., “Extracellular Tax


protein of human cell leukemia virus type 1 activates monocyte-derived dendritic cells and anhances their maturation, function, and antigen-specific T cell proliferation”, 7th International Symposium on NeuroVirology, Philadelphia, May 31-June 3.

2006 Shimizu S., Khan MZ., Hippensteel RL, and Meucci O. “Expression of the E2F1 transcriptional targets, Cdc2 and PUMA, in primary neurons treated with HIV-gp120 and in the brain of HIV/HAD patients”, 7th International Symposium on NeuroVirology, Philadelphia, May 31-June 3.

2007 Nicolai JL, Khan MZ, Shimizu S., and Meucci O. “Inhibition of the E2F1 target cdc2 prevents HIVgp120-induced neurotoxicity” 13th SNIP Conference, Salt Lake City, April 11-14

2007 Sengupta R, Burbassi S., Shimizu S., and Meucci O. “DAMGO regulates neuronal CXCR4 via a glia independent mechanism involving CXCR4 phosphorylation”, 13th SNIP Conference, Salt Lake City, April 11-14

2007 Hippensteel R., Shimizu S., Fatatis A., and Meucci O. “CXCL12 stimulates production of CX3CL1 by cortical neurons”, 13th SNIP Conference, Salt Lake City, April 11-14

2007 Burbassi, S. Aloyo V, Chaijale N., Simansky K., and Meucci O. “GTPγS incorporation in the rat brain: a study on µ-opioid receptors and CXCR4” 13th SNIP Conference, Salt Lake City, April 11-14

2007 Hippensteel R., Shimizu S., and Meucci O. “ CXCL12-induced cleavage of CX3CL1: potential role in neuroprotection”, 8th Meeting of the Society of Neurovirology, San Diego October 29 – November 2.

2007 Burbassi S., Sengupta R., Simansky K.J., and Meucci O., “Inhibition of CXCR4-mediated G protein stimulation in the cortex and the hippocampus of morphine-treated animals”, 8th Meeting of the Society of Neurovirology, San Diego October 29 – November 2.

2007 Nicolai J., Khan M.Z., Shimizu S., Meucci O. “Activation of the cell cycle protein Cdc2 may cause calcium dysregulation in postmitotic neurons contributing to HIV-induced excitotoxicity and neuronal cell death”, 8th Meeting of the Society of Neurovirology, San Diego October 29 – November 2 (Poster selected for oral presentation).

2007 Shimizu S., Meucci O, and Ellis-Davies G. “Two-photon uncaging of glutamate in the cortex of living mice”, 37th Annual Meeting of the Society for Neuroscience, San Diego, California November 3-7

2007 Khan MZ, Brandimarti R, and Meucci O. “The chemokine CXCL12 promotes retinoblastoma protein function in postmitotic cortical neurons by stimulating its expression, nuclear localization and transcriptional activity”, 37th Annual Meeting of the Society for Neuroscience, San Diego, California, November 3-7

2007 Sengupta R., Burbassi S, and Meucci O. “Coupling of neuronal CXCR4 to survival pathways is altered after in vitro or in vivo opiate treatments”, 37th Annual Meeting of the Society for Neuroscience, San Diego, California, November 3-7

2008 Burbassi S., Peiris TH., Chang S., Simansky KJ., and Meucci O. “Expression and function of the chemokine receptor CXCR4 in the brain of morphine-treated animals”, 14th Annual Meeting of the Society on NeuroImmune Pharmacology,” Charleston, SC, March 12-15.

2008 Nicolai J., Khan MK, and Meucci O. “CXCL12 inhibits NMDA-induced calcium responses in cortical neurons and alters the expression of the NR2B subunit”. 38th Annual Meeting


of the Society for Neuroscience, Washington DC, November 15-19.

2008 Sengupta R., Burbassi S, Shimizu S. and Meucci O. “Morphine increases brain levels of Ferritin Heavy Chain”. 38th Annual Meeting of the Society for Neuroscience, Washington DC, November 15-19.

2008 Burbassi S. and Meucci O. “Alterations of CXCR4 function in the brain of MOR-deficient mice”. 38th Ann. Meeting of the Society for Neuroscience, Washington DC, November 15-19.

2009 Sengupta R., Burbassi S, and Meucci O. “Morphine inhibits neuronal survival signaling stimulated by CXCR4 by increasing brain levels of Ferritin Heavy Chain” 15th Annual Conference of the Society on NeuroImmune Pharmacology, Wuhan, China, April 21-24

2009 Nicolai J. and Meucci O. “The chemokine CXCL12 regulates expression of the NMDA receptor subunit NR2B via a Histone Deacetylase - dependent pathway”. 9th Meeting of the International Society of Neurovirology, Miami (FL) June 2-7

2009 Pitcher J., Shimizu S, Burbassi S., Sengupta S., and Meucci O. “Role of Ferritin Heavy Chain and opiates in neuroAIDS” ”. 9th Meeting of the International Society of Neurovirology, Miami (FL) June 2-7

2009 Cook A., Hippensteel R., Nicolai J., and Meucci O. “Regulation of Neuronal ADAM17 by the Chemokine SDF-1/CXCL12 and its Role in Fractalkine/CX3CL1 Cleavage”, 9th Meeting of the International Society of Neurovirology, Miami (FL) June 2-7

2009 Nicolai J. and Meucci O “ Different contribution of synaptic and extra-synaptic excitatory signaling to the effects of the chemokine CXCL12 in cortical neurons”, 39th Annual Meeting of the Society for Neuroscience, Chicago IL, October 17-21

2009 Burbassi S., Sengupta R., and Meucci O “Role of d opioid receptors in the reduced CXCL12/CXCR4 signaling in MOR-deficient mice”, 39th Annual Meeting of the Society for Neuroscience, Chicago IL, October 17-21

2009 Khan MZ, Vaiyda A. and Meucci O. “Regulation of LANP/ANP32A by the chemokine CXCL12 and its role in neuronal survival., 39th Annual Meeting of the Society for Neuroscience, Chicago IL, October 17-21

2010 Nicolai J., Burbassi S., Rubin J., and Meucci O. “The Chemokine CXCL12 regulates expression of the NMDA receptor’s NR2B subunit through a Histone Deacetylase dependent pathway contributing to neuronal survival” 16th Annual Conference of the Society on NeuroImmune Pharmacology, Anaheim Beach, CA April 13-17

2010 Burbassi S., Sengupta R., and Meucci O., “CXCR4/DOR Interactions in the brain of MOR-deficient mice”, 16th Annual Conference of the Society on NeuroImmune Pharmacology, Anaheim Beach, CA April 13-17

2010 Pitcher J., Shimizu S, Burbassi S., Sengupta R., and Meucci O. “Role of FHC in neuroAIDS:a systematic in vivo analysis of a novel CXCR4 regulator within the human cortex” ASCI/AAP 2010 Joint Meeting April 23-25, 2010 Fairmont Hotel, Chicago, IL.

2010 Burbassi S. and Meucci O. “Increased interaction between the δ-opioid and CXCR4 chemokine receptor is implicated inthe reduced CXCL12/CXCR4 signaling in MOR-deficient mice”, 10th International Symposium on NeuroVirology & 2010 Conference on HIV in the Nervous System, Milan, Italy October 12-16.

2010 Pitcher J., Shimizu S., Burbassi S., and Meucci O. “Ferritin heavy chain, CXCR4 and opiates in neuroAIDS: a multispectral image analysis within the human cortex”, 10th


International Symposium on NeuroVirology & 2010 Conference on HIV in the Nervous System, Milan, Italy October 12-16.

2011 Abt Cook A, Festa L, and Meucci O “Effect of morphine on expression of heavy and light chain subunits of the ferritin protein complex in neurons”. Neuroscience 2011, 41st Annual Meeting of the Society for Neuroscience, Washington DC, November 12-16.

2011 Pitcher J., Shimizu S., Burbassi S., and Meucci O “Increased levels of ferritin heavy chain protein in the cortical neurons of patients with a history of drug abuse”. Neuroscience 2011, 41st Annual Meeting of the Society for Neuroscience, Washington DC, November 12-16.

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