Guidelines and Guidance Guideline Synthesis National Guideline Clearinghouse (NGC) Guideline Synthesis [US] Diagnosis and Management of Stable Chronic Obstructive Pulmonary Disease (COPD) Guidelines Being Compared: 1. American College of Physicians, American College of Chest Physicians, American Thoracic Society,

and European Respiratory Society (ACP/ACCP/ATS/ERS). Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society. Ann Intern Med 2011 Aug 2;155(3):179-191. [62 references]

2. British Thoracic Society (BTS). British Thoracic Society guideline on pulmonary rehabilitation in adults. Thorax. 2013 Sep;68(Suppl 2):ii1-30. [211 references]

3. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Vancouver (WA): Global Initiative for Chronic Obstructive Lung Disease (GOLD); 2013. 80 p. [547 references]

http://www.guideline.gov/syntheses/synthesis.aspx?f=rss&id=48263

Journal articles

Thorax, July 2014, Volume 69, Issue 7

Editorials

The devastating power of platelets in COPD exacerbations: can aspirin save lives in COPD? Don D Sin Thorax 2014;69:603-604 [Extract] Using absolute risks to assess the risks and benefits of treatment Mitchell H Gail Thorax 2014;69:604-605 [Extract] Red, amber and green: the role of the lung in de-priming active systemic neutrophils

Current Awareness Bulletin

Respiratory Medicine

July 2014

Elizabeth Sapey, Robert A Stockley Thorax 2014;69:606-608 [Extract]

Chronic obstructive pulmonary disease

Original article: Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy? Michelle T Harrison, Philip Short, Peter A Williamson, Aran Singanayagam, James D Chalmers, Stuart Schembri Thorax 2014;69:609-615 [Abstract] Original article: Benefits and harms of roflumilast in moderate to severe COPD Tsung Yu, Kevin Fain, Cynthia M Boyd, Sonal Singh, Carlos O Weiss, Tianjing Li, Ravi Varadhan, Milo A Puhan Thorax 2014;69:616-622 [Abstract]

Critical care

Original article: Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome Charlotte Summers, Nanak R Singh, Jessica F White, et al. Thorax 2014;69:623-629 [Abstract][Full text][PDF][Supplementary Data][Request permissions]

FREE

Lung cancer

Original article: Systemic but not topical TRAIL-expressing mesenchymal stem cells reduce tumour growth in malignant mesothelioma Elizabeth K Sage, Krishna K Kolluri, Katrina McNulty, et al. Thorax 2014;69:638-647 [Abstract][Full text][PDF][Supplementary Data][Request permissions]

Original article: Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence M A Cañizares, J M Matilla, A Cueto, et al. EMETNE-SEPAR Members Thorax 2014;69:648-653 [Abstract]

Respiratory epidemiology

Original article: Epidemiological time series studies of PM2.5 and daily mortality and hospital admissions: a systematic review and meta-analysis R W Atkinson, S Kang, H R Anderson, I C Mills, H A Walton Thorax 2014;69:660-665 [Abstract][Full text][PDF][Supplementary Data][Request permissions]

Review

Lessons from ECLIPSE: a review of COPD biomarkers Rosa Faner, Ruth Tal-Singer, John H Riley, et al. Thorax 2014;69:666-672 [Abstract]

Research letter

The impact of azithromycin therapy on the airway microbiota in asthma Mariel Slater, Damian W Rivett, Lisa Williams, et al. Thorax 2014;69:673-674 [Extract][Full text][PDF][Supplementary Data][Request permissions]

Chest clinic

Audit, research and guideline update

Audit, research and guideline update: Cost effectiveness of endosonography versus surgical staging in potentially resectable lung cancer: a health economics analysis of the ASTER trial from a European perspective Robert C Rintoul, Matthew J Glover, Christopher Jackson et al. Thorax 2014;69:679-681 [Abstract]

Basic science for the chest physician

Basic science for the chest physician: Protease-mediated ectodomain shedding Peter Clark Thorax 2014;69:682-684 [Abstract]

Case based discussions

Case based discussions: Recurrent pneumothoraces in a 17-year-old man with mixed connective tissue disease Claire McBrien, Andrea Penketh, Hilary Johnson, Andrew G Nicholson, Athol Wells Thorax 2014;69:685-686 [Extract]

American Journal of Respiratory and Critical Care Medicine Volume 190, Issue 1 (July 1, 2014)

Macrolide Antibiotics for Prevention of Chronic Obstructive Pulmonary Disease Exacerbations: Are We There Yet? Marcos I. Restrepo, and Antonio Anzueto American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: 1-2. http://www.atsjournals.org/doi/abs/10.1164/rccm.201406-1014ED?ai=s0&ui=1ytu&af=T Reduced Antibacterial Immunity in Chronic Obstructive Pulmonary Disease: A Key Role for Lymphocytes? Dave Singh American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: 3-4. http://www.atsjournals.org/doi/abs/10.1164/rccm.201406-0997ED?ai=s0&ui=1ytu&af=T Untangling the Healthcare Use Patterns of Severe Sepsis Survivors Hannah Wunsch American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: 7-8. http://www.atsjournals.org/doi/abs/10.1164/rccm.201406-1032ED?ai=s0&ui=1ytu&af=T Tuberculosis, Pulmonary Cavitation, and Matrix Metalloproteinases Catherine W. M. Ong, Paul T. Elkington,, and Jon S. Friedland American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: 9-18.

http://www.atsjournals.org/doi/abs/10.1164/rccm.201311-2106PP?ai=s0&ui=1ytu&af=T Update in Lung Transplantation 2013 Jamie L. Todd, Jason D. Christie, and Scott M. Palmer American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: 19-24. http://www.atsjournals.org/doi/abs/10.1164/rccm.201402-0384UP?ai=s0&ui=1ytu&af=T Update in Sepsis and Pulmonary Infections 2013 Richard G. Wunderink and Keith R. Walley American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: 25-31. http://www.atsjournals.org/doi/abs/10.1164/rccm.201403-0577UP?ai=s0&ui=1ytu&af=T Increased 1-Year Healthcare Use in Survivors of Severe Sepsis Hallie C. Prescott, Kenneth M. Langa,,, Vincent Liu, Gabriel J. Escobar, and Theodore J. Iwashyna,, American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: 62-69. http://www.atsjournals.org/doi/abs/10.1164/rccm.201403-0471OC?ai=s0&ui=1ytu&af=T Oxygenation Response to Positive End-Expiratory Pressure Predicts Mortality in Acute Respiratory Distress Syndrome. A Secondary Analysis of the LOVS and ExPress Trials Ewan C. Goligher, Brian P. Kavanagh, Gordon D. Rubenfeld, et al. American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: 70-76. http://www.atsjournals.org/doi/abs/10.1164/rccm.201404-0688OC?ai=s0&ui=1ytu&af=T Study of Active Duty Military for Pulmonary Disease Related to Environmental Deployment Exposures (STAMPEDE) Michael J. Morris, Darrel W. Dodson, Pedro F. Lucero, et al. American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: 77-84. http://www.atsjournals.org/doi/abs/10.1164/rccm.201402-0372OC?ai=s0&ui=1ytu&af=T Pulmonary Arterial Mycotic Pseudoaneurysms in a Patient with Invasive Pulmonary Aspergillosis. Successful Occlusion by Coils Morgane Didier, Pierre Guedin, Fabrice Staub, et al. American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: 112-113. http://www.atsjournals.org/doi/abs/10.1164/rccm.201310-1780IM?ai=s0&ui=1ytu&af=T Placental Transmogrification of the Lung: A Rare Cause of Unilateral Bullous Disease Michael P. Mohning, Marvin I. Schwarz, and Sarah J. McKinley American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: e1-e1. http://www.atsjournals.org/doi/abs/10.1164/rccm.201307-1361IM?ai=s0&ui=1ytu&af=T Mounier-Kuhn Syndrome. Imaging and Bronchoscopic Findings Karim El-Kersh, Muhammad Yasin, Rodrigo Cavallazzi, and Rafael L. Perez American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: e2-e3. http://www.atsjournals.org/doi/abs/10.1164/rccm.201307-1306IM?ai=s0&ui=1ytu&af=T Sleep-related Periodic Breathing Does Not Acclimatize to Chronic Hypobaric Hypoxia: A 1-Year Study at High Altitude in Antarctica Helio Fernandez Tellez, Olivier Mairesse, Eoin Macdonald-Nethercott, et al. American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 1: 114-116. http://www.atsjournals.org/doi/abs/10.1164/rccm.201403-0598LE?ai=s0&ui=1ytu&af=T

American Journal of Respiratory and Critical Care Medicine Volume 190, Issue 2 (July 15, 2014)

Inhaled Interferon: A Novel Treatment for Virus-induced Asthma? Daniel J. Jackson, American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 123-124. http://www.atsjournals.org/doi/abs/10.1164/rccm.201406-1131ED?ai=s0&ui=1ytu&af=T

The Lipidome: A New Player in Chronic Obstructive Pulmonary Disease Pathophysiology? Louise E. Donnelly, American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 124-125. http://www.atsjournals.org/doi/abs/10.1164/rccm.201406-1061ED?ai=s0&ui=1ytu&af=T A New Player in the Game: Epithelial Cathepsin S in Early Cystic Fibrosis Lung Disease Marcus A. Mall, and Carsten Schultz American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 126-127. http://www.atsjournals.org/doi/abs/10.1164/rccm.201405-0935ED?ai=s0&ui=1ytu&af=T Ivacaftor: From Bench to Bedside . . . and Back Again Kevin Molloy, and Noel G. McElvaney American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 128-129. http://www.atsjournals.org/doi/abs/10.1164/rccm.201406-1122ED?ai=s0&ui=1ytu&af=T Pulmonary Hypertension due to Fibrotic Lung Disease: Hidden Value in a Neutral Trial Steven D. Nathan, and Roberto G. Carbone, American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 131-132. http://www.atsjournals.org/doi/abs/10.1164/rccm.201406-1094ED?ai=s0&ui=1ytu&af=T Sleep Apnea and Diabetes: Good Friends or Something More? Jessie P. Bakker, and Sanjay R. Patel, American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 133-134. http://www.atsjournals.org/doi/abs/10.1164/rccm.201406-1081ED?ai=s0&ui=1ytu&af=T Using Pulmonary Imaging to Move Chronic Obstructive Pulmonary Disease beyond FEV1 Harvey O. Coxson, Jonathon Leipsic, Grace Parraga, and Don D. Sin American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 135-144. http://www.atsjournals.org/doi/abs/10.1164/rccm.201402-0256PP?ai=s0&ui=1ytu&af=T The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections. A Randomized Trial Ratko Djukanović, Tim Harrison, Sebastian L. Johnston, et al., and the INTERCIA Study Group American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 145-154. http://www.atsjournals.org/doi/abs/10.1164/rccm.201312-2235OC?ai=s0&ui=1ytu&af=T Untargeted Lipidomic Analysis in Chronic Obstructive Pulmonary Disease. Uncovering Sphingolipids Eef D. Telenga, Roland F. Hoffmann, Ruben t’Kindt, et al. American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 155-164. http://www.atsjournals.org/doi/abs/10.1164/rccm.201312-2210OC?ai=s0&ui=1ytu&af=T Respiratory Syncytial Virus Increases the Virulence of Streptococcus pneumoniae by Binding to Penicillin Binding Protein 1a. A New Paradigm in Respiratory Infection Claire M. Smith, Sara Sandrini, Sumit Datta, et al. American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 196-207. http://www.atsjournals.org/doi/abs/10.1164/rccm.201311-2110OC?ai=s0&ui=1ytu&af=T Bosentan in Pulmonary Hypertension Associated with Fibrotic Idiopathic Interstitial Pneumonia Tamera J. Corte, Gregory J. Keir, Konstantinos Dimopoulos, et al.; for the BPHIT Study Group American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 208-217. http://www.atsjournals.org/doi/abs/10.1164/rccm.201403-0446OC?ai=s0&ui=1ytu&af=T Obstructive Sleep Apnea and Incident Diabetes. A Historical Cohort Study Tetyana Kendzerska, Andrea S. Gershon, Gillian Hawker, George Tomlinson, and Richard S. Leung American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 218-225. http://www.atsjournals.org/doi/abs/10.1164/rccm.201312-2209OC?ai=s0&ui=1ytu&af=T

Endobronchial Tuberculosis with Anthracofibrosis Laura M. Paulin, Natalie E. West, Jason A. Akulian, and Brian T. Garibaldi American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 226-226. http://www.atsjournals.org/doi/abs/10.1164/rccm.201310-1760IM?ai=s0&ui=1ytu&af=T Bronchial Chloroma Saadia A. Faiz, Nelson G. Ordonez, Rodolfo C. Morice, Lara Bashoura, and Carlos A. Jimenez American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: e5-e6. http://www.atsjournals.org/doi/abs/10.1164/rccm.201309-1624IM?ai=s0&ui=1ytu&af=T Neural Respiratory Drive and Ventilation in Patients with Chronic Obstructive Pulmonary Disease during Sleep Yuan-Ming Luo, Bai-Ting He, Yin-Xin Wu, Hong Yuan, Jing Xu, John Moxham, and Michael Polkey American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 227-229. http://www.atsjournals.org/doi/abs/10.1164/rccm.201402-0302LE?ai=s0&ui=1ytu&af=T Nuclear Magnetic Resonance–based Metabolomics Discriminates Primary Ciliary Dyskinesia from Cystic Fibrosis Paolo Montuschi, Debora Paris, Silvia Montella, et al. American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 229-233. http://www.atsjournals.org/doi/abs/10.1164/rccm.201402-0249LE?ai=s0&ui=1ytu&af=T Patients with Asthma Demonstrate Airway Inflammation after Exposure to Concentrated Ambient Particulate Matter Neil E. Alexis, Yuh Chin T. Huang, Ana G. Rappold, Howard Kehrl, Robert Devlin, and David B. Peden, American Journal of Respiratory and Critical Care Medicine, Vol. 190, No. 2: 235-237. http://www.atsjournals.org/doi/abs/10.1164/rccm.201401-0126LE?ai=s0&ui=1ytu&af=T

European Respiratory Journal July 1, 2014; 44 (1)

Editorials

Ensuring that the diagnosis of tuberculosis accelerates progress towards the Millennium Development Goals Christy Hanson, Giovanni Sotgiu, and Robert Loddenkemper Eur Respir J 2014 44:1-4 http://erj.ersjournals.com/content/44/1/1.extract Good news about a bad subject: scientific evidence to help defeat multidrug/extensively drug-resistant tuberculosis Giovanni Sotgiu and Mark Woodhead Eur Respir J 2014 44:5-7 http://erj.ersjournals.com/content/44/1/5.extract COPD in nonsmokers: the biomass hypothesis – to be or not to be? Louisa Gnatiuc and Gaetano Caramori Eur Respir J 2014 44:8-10 http://erj.ersjournals.com/content/44/1/8.extract Viral, bacterial or both? Regardless, we need to treat infection in COPD Tobias Welte and Marc Miravitlles Eur Respir J 2014 44:11-13 http://erj.ersjournals.com/content/44/1/11.extract Airway and systemic eosinophilia in asthma: does site matter? Konstantinos Kostikas, Eleftherios Zervas, and Mina Gaga Eur Respir J 2014 44:14-16

http://erj.ersjournals.com/content/44/1/14.extract Oxidative stress in cystic fibrosis lung disease: an early event, but worth targeting? Andreas Hector, Matthias Griese, and Dominik Hartl Eur Respir J 2014 44:17-19 http://erj.ersjournals.com/content/44/1/17.extract

European Lung Corner

www.smokehaz.eu – a review of the evidence on smoking and lung health Brian Ward Eur Respir J 2014 44:20-22 http://erj.ersjournals.com/content/44/1/20.extract

Consensus Statement

Tuberculosis

Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement Christoph Lange, Ibrahim Abubakar, Jan-Willem C. Alffenaar, et al., for the TBNET Eur Respir J 2014 44:23-63 OPEN ACCESS ARTICLE http://erj.ersjournals.com/content/44/1/23.abstract

Original Articles

Epidemiology

Prevalence and correlates of airflow obstruction in ∼317 000 never-smokers in China Margaret Smith, Liming Li, Mareli Augustynet al., on behalf of the China Kadoorie Biobank collaborative group Eur Respir J 2014 44:66-77 OPEN ACCESS ARTICLE http://erj.ersjournals.com/content/44/1/66.abstract

COPD

Performance of the BODE index in patients with α1-antitrypsin deficiency-related COPD Gabriel Thabut, Jean-François Mornex, Christophe Pison, et al. Eur Respir J 2014 44:78-86 http://erj.ersjournals.com/content/44/1/78.abstract

COPD and respiratory infections

Human rhinovirus infection during naturally occurring COPD exacerbations Sîobhán N. George, Davinder S. Garcha, Alexander J. Mackay, et al. Eur Respir J 2014 44:87-96 http://erj.ersjournals.com/content/44/1/87.abstract

Asthma

Importance of concomitant local and systemic eosinophilia in uncontrolled asthma Florence Nicole Schleich, Anne Chevremont, Virginie Paulus et al. Eur Respir J 2014 44:97-108 http://erj.ersjournals.com/content/44/1/97.abstract

Sleep

Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: the ESADA study Brian D. Kent, Ludger Grote, Maria R. Bonsignore, et al., on behalf of the European Sleep Apnoea Database collaborators Eur Respir J 2014 44:130-139 http://erj.ersjournals.com/content/44/1/130.abstract Zonisamide reduces obstructive sleep apnoea: a randomised placebo-controlled study Davoud Eskandari, Ding Zou, Mahssa Karimi, Kaj Stenlöf, Ludger Grote, and Jan Hedner Eur Respir J 2014 44:140-149 http://erj.ersjournals.com/content/44/1/140.abstract

Pulmonary vascular diseases

Predicting the size of pulmonary arteriovenous malformations on chest computed tomography: a role for transthoracic contrast echocardiography Sebastiaan Velthuis, Elisabetta Buscarini, Johannes J. Mager, et al. Eur Respir J 2014 44:150-159 http://erj.ersjournals.com/content/44/1/150.abstract

Respiratory infections

Prolonged shedding of rhinovirus and re-infection in adults with respiratory tract illness Kalina T. Zlateva, Jutte J.C. de Vries, Frank E.J. Coenjaerts, et al., on behalf of the GRACE Study Group Eur Respir J 2014 44:169-177 http://erj.ersjournals.com/content/44/1/169.abstract

Interstitial lung diseases

Lung transplantation in telomerase mutation carriers with pulmonary fibrosis Leann L. Silhan, Pali D. Shah, Daniel C. Chambers, et al. Eur Respir J 2014 44:178-187 OPEN ACCESS ARTICLE http://erj.ersjournals.com/content/44/1/178.abstract

Acute lung injury and critical care

Exhaled breath metabolomics as a noninvasive diagnostic tool for acute respiratory distress syndrome Lieuwe D.J. Bos, Hans Weda, Yuanyue Wang, et al. Eur Respir J 2014 44:188-197 http://erj.ersjournals.com/content/44/1/188.abstract

Scientific Assembly Update

Clinical highlights from the 2013 ERS Congress in Barcelona Martijn A. Spruit, Maurizio Marvisi, Johan Coolen, et al. Eur Respir J 2014 44:198-206 http://erj.ersjournals.com/content/44/1/198.abstract

Review

Microparticles and vascular dysfunction in obstructive sleep apnoea Wojciech Trzepizur, Maria Carmen Martinez, Pascaline Priou, et al. Eur Respir J 2014 44:207-216 http://erj.ersjournals.com/content/44/1/207.abstract

Series

Number 2 in the series “Challenges and Controversies in Thoracic Oncology”: Screening for lung cancer: time for large-scale screening by chest computed tomography Dekel Shlomi, Ronny Ben-Avi, Gingy Ronen Balmor, Amir Onn, and Nir Peled Eur Respir J 2014 44:217-238 http://erj.ersjournals.com/content/44/1/217.abstract

Agora

Research letters

The role of mepolizumab in atopic and nonatopic severe asthma with persistent eosinophilia Hector Ortega, Geoffrey Chupp, Philip Bardin, et al. Eur Respir J 2014 44:239-241 http://erj.ersjournals.com/content/44/1/239.extract Between-visit variability of small airway obstruction markers in patients with asthma Sherif Gonem, Steven Corkill, Amisha Singapuri, et al. Eur Respir J 2014 44:242-244 http://erj.ersjournals.com/content/44/1/242.extract Job strain and COPD exacerbations: an individual-participant meta-analysis Katriina Heikkilä, Ida E.H. Madsen, Solja T. Nyberg, et al., for the IPD-Work Consortium Eur Respir J 2014 44:247-251 OPEN ACCESS ARTICLE http://erj.ersjournals.com/content/44/1/247.extract HIV and multidrug-resistant tuberculosis: overlapping epidemics Anna S. Dean, Matteo Zignol, Dennis Falzon, Haileyesus Getahun, and Katherine Floyd Eur Respir J 2014 44:251-254 http://erj.ersjournals.com/content/44/1/251.extract Rapid diagnosis of tuberculosis using ex vivo host biomarkers in sputum Martin O.C. Ota, Joseph F. Mendy, Simon Donkor, Toyin Togun, Mohammed Daramy, Marie P. Gomez, Novel N. Chegou, Abdou K. Sillah, Olumuyiwa Owolabi, Beate Kampmann, Gerhard Walzl, and Jayne S. Sutherland Eur Respir J 2014 44:254-257 http://erj.ersjournals.com/content/44/1/254.extract Serial testing using interferon-γ release assays in nursing students in India Alice Zwerling, Madhukar Pai, Joy Sarojini Michael, and Devasahayam J. Christopher Eur Respir J 2014 44:257-260 http://erj.ersjournals.com/content/44/1/257.extract

CHEST: July 2014; Volume 146, Number 1

Editorials

Lung Protective Ventilation in Donors: An Ounce of Prevention Julia A. Klesney-Tait; Michael Eberlein Chest. 2014;146(1):4-6. Better Outcomes From Pneumococcal Pneumonia: How Good Is Your Care? Grant W. Waterer Chest. 2014;146(1):6-8. Interstitial Lung Abnormalities in Rheumatoid Arthritis Are Common and Important Aryeh Fischer; Gregory P. Cosgrove Chest. 2014;146(1):8-10.

The Need for Humanomics in the Era of Genomics and the Challenge of Chronic Disease Management J. Mark FitzGerald; Iraj Poureslami Chest. 2014;146(1):10-12.

Second Opinion

Commentary

Bronchial Thermoplasty: Reappraising the Evidence (or Lack Thereof) Vivek N. Iyer; Kaiser G. Lim Chest. 2014;146(1):17-21.

Original Research: Chest Infections

Decrease in Mortality in Severe Community-Acquired Pneumococcal Pneumonia: Impact of Improving Antibiotic Strategies (2000-2013) Simone Gattarello; Bárbara Borgatta; Jordi Solé-Violán; et al.; for the Community-Acquired Pneumonia en la Unidad de Cuidados Intensivos II Study Investigators Chest. 2014;146(1):22-31. Soluble Major Histocompatibility Complex Class I-Related Chain B Molecules Are Increased and Correlate With Clinical Outcomes During Rhinovirus Infection in Healthy Subjects Aurica G. Telcian; Mihnea T. Zdrenghea; Gaetano Caramori; et al. Chest. 2014;146(1):32-40.

Original Research: Diffuse Lung Disease

Functional Impact of a Spectrum of Interstitial Lung Abnormalities in Rheumatoid Arthritis Tracy J. Doyle; Paul F. Dellaripa; Kerri Batra; et al. Chest. 2014;146(1):41-50.

Original Research: Critical Care

Thrombosis Prophylaxis and Mortality Risk Among Critically Ill Adults Craig M. Lilly; Xinggang Liu; Omar Badawi; Christine S. Franey; Ilene H. Zuckerman Chest. 2014;146(1):51-57. Ventilator-Associated Pneumonia During Weaning From Mechanical Ventilation: Role of Fluid Management Armand Mekontso Dessap; Sandrine Katsahian; Ferran Roche-Campo; et al. Chest. 2014;146(1):58-65.

Original Research: Sleep Disorders

OSA Is Common and Independently Associated With Hypertension and Increased Arterial Stiffness in Consecutive Perimenopausal Women Rodrigo P. Pedrosa; Isly M. L. Barros; Luciano F. Drager; et al. Chest. 2014;146(1):66-72. Left Atrial Size, Chemosensitivity, and Central Sleep Apnea in Heart Failure Andrew D. Calvin; Virend K. Somers; Bruce D. Johnson; Christopher G. Scott; Lyle J. Olson Chest. 2014;146(1):96-103.

Original Research: COPD

Determinants of Gait Speed in COPD Craig Karpman; Zachary S. DePew; Nathan K. LeBrasseur; Paul J. Novotny; Roberto P. Benzo Chest. 2014;146(1):104-110.

Clinical Application of the COPD Assessment Test: Longitudinal Data From the COPD History Assessment in Spain (CHAIN) Cohort Juan P. de Torres; Jose M. Marin; Cristina Martinez-Gonzalez; et al.; for the COPD History Assessment in Spain (CHAIN) Cohort Chest. 2014;146(1):111-122.

Original Research: Signs and Symptoms of Chest Disease

Attentional Modulation of Reflex Cough Thomas Janssens; Mitchell Silva; Paul W. Davenport; Ilse Van Diest; Lieven J. Dupont; Omer Van den Bergh Chest. 2014;146(1):135-141.

Original Research: Genetic and Developmental Disorders

Pulmonary Medication Adherence and Health-care Use in Cystic Fibrosis Alexandra L. Quittner; Jie Zhang; Maryna Marynchenko; et al. Chest. 2014;146(1):142-151. Effects of Ivacaftor in Patients With Cystic Fibrosis Who Carry the G551D Mutation and Have Severe Lung Disease Peter J. Barry; Barry J. Plant; Arjun Nair; et al. Chest. 2014;146(1):152-158.

Original Research: Pulmonary Vascular Disease

Causes of Pulmonary Hypertension in the Elderly Meredith E. Pugh; Lakshmi Sivarajan; Li Wang; Ivan M. Robbins; John H. Newman; Anna R. Hemnes Chest. 2014;146(1):159-166.

Original Research: Lung Cancer

Impact of Histologic Subtyping on Outcome in Lobar vs Sublobar Resections for Lung Cancer: A Pilot Study Francine R. Dembitzer; Raja M. Flores; Michael K. Parides; Mary Beth Beasley Chest. 2014;146(1):175-181.

Evidence-Based Medicine

Methodologies for the Development of CHEST Guidelines and Expert Panel Reports Sandra Zelman Lewis; Rebecca Diekemper; Joseph Ornelas; Kenneth R. Casey Chest. 2014;146(1):182-192.

Recent Advances in Chest Medicine

Whooping Cough in 2014 and Beyond: An Update and Review Joshua D. Hartzell; Jason M. Blaylock Chest. 2014;146(1):205-214. d

Contemporary Reviews in Critical Care Medicine

Mechanical Ventilatory Support in Potential Lung Donor Patients Ruchi Bansal; Adebayo Esan; Dean Hess; Luis F. Angel; Stephanie M. Levine; Tony George; Suhail Raoof Chest. 2014;146(1):220-227.

Contemporary Reviews in Sleep Medicine

Sleep-Disordered Breathing in Hypertrophic Cardiomyopathy: Challenges and Opportunities

Tomas Konecny; Virend K. Somers Chest. 2014;146(1):228-234.

Chest Imaging and Pathology for Clinicians

A 70-Year-Old Woman With Dyspnea and Chest Pain Aarthi Ganesh; Michael Flores; Isabel Oliva; Gordon E. Carr Chest. 2014;146(1):e14-e18.

Pulmonary, Critical Care, and Sleep Pearls

A 26-Year-Old Man With a Slowly Growing Heterogeneous Intrathoracic Mass Julianne Nichols; Natalie Berger; Vanessa Yap; Daniel Fusco; Debapriya Datta Chest. 2014;146(1):e19-e23.

Articles from Other Journals Epidemiology and clinical management of Legionnaires' disease. Phin N, Parry-Ford F, Harrison T, Stagg HR, Zhang N, Kumar K, Lortholary O, Zumla A, Abubakar I. Lancet Infect Dis. 2014 Jun 23. pii: S1473-3099(14)70713-3. [Epub ahead of print] Review.

An early rehabilitation intervention to enhance recovery during hospital admission for an exacerbation of chronic respiratory disease: randomised controlled trial Neil J Greening, Johanna E A Williams, Syed F Hussain, et al. BMJ 2014;349:g4315 http://www.bmj.com/content/349/bmj.g4315?etoc=

Educational, supportive and behavioural interventions to improve usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea. Wozniak DR, Lasserson TJ, Smith I. Cochrane Database Syst Rev. 2014 Jan 8;1:CD007736. Review.

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