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![Page 1: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/1.jpg)
Crohn’s disease - A Review of Symptoms and Treatment
Brian NguyenUniversity of California - Irvine Medical Center, Orange, CA
![Page 2: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/2.jpg)
Background
• Inflammatory bowel disease in large intestine and rectum– May occur in any part of GI tract
• Chronic condition• Onset occurs 16-40 yrs old• Exact cause unknown– Genetic risk factors
![Page 3: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/3.jpg)
Background
• Autoimmune disorder• Immune system attacks normal microbes– White blood cells rush lining– Chronic inflammation
• Similar symptoms to ulcerative colitis– UC affects superficial layers and colon only– CD affects all layers and GI tract
![Page 4: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/4.jpg)
Usually found in ileocecal region (small intestine to large intestine)
![Page 5: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/5.jpg)
Colon with Crohn’s disease Normal colon
![Page 6: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/6.jpg)
Symptoms
• Periods of flare ups• Abdominal pain• Diarrhea• Fever• Weight loss• Anal pain
![Page 7: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/7.jpg)
Complications
• Obstruction of bowel– Swelling or scar tissue
• Ulcers in tract– Can result in fistulas (30%)– Abscess
• Malnutrition– Inadequate intake and absorption
![Page 8: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/8.jpg)
Diagnosis
• Colonoscopy (70% effective)– Visualization of colon and terminal ileum
• Radiological studies– Can help see remainder of small intestine– Highlights inflammation
• Blood tests– Anemia indication for Crohn’s
![Page 9: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/9.jpg)
Treatment
• No “cure” – only symptom relief• Medication– Cortisteroids or anti-inflammatory agents– Immunosuppressive drugs
• Surgery – Remove diseased portion of intestine– Anastomosis connects remaining bowel– 50% patients have recurrence within 5 years
![Page 10: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/10.jpg)
Surgery
Total proctocolectomy with ileostomy
![Page 11: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/11.jpg)
Surgery
Total colectomy with ileorectal anastomosis
![Page 12: Crohn’s disease - A Review of Symptoms and Treatment Brian Nguyen University of California - Irvine Medical Center, Orange, CA.](https://reader036.fdocuments.net/reader036/viewer/2022072010/56649da95503460f94a9690f/html5/thumbnails/12.jpg)
Prognosis
• No cure• Higher risk for colon cancer• Long periods of remission