Creating a System of Precision Oncology Excellence in the Veterans Health Administration ·...
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Creating a System of Precision
Oncology Excellence in the
Veterans Health Administration
Michael J Kelley, MD
National Program Director for Oncology
Chief, Hematology-Oncology
Durham VA Medical Center
Department of Veterans Affairs
Professor of Medicine
Duke University Medical Center
Matthew Rettig, MD
Chief, Hematology-Oncology
VA Greater Los Angeles
Co-Chair, VA POPCaP
Professor of Medicine and Urology
Medical Director, Prostate Cancer Program
David Geffen School of Medicine at UCLA
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Disclosures
Michael Kelley Matthew Rettig
• Research funding from AstraZeneca, Bristol Myers Squibb, Novartis
• Consultant for IBM Japan
• Gift from IBM Watson for use of Watson for Genomics at the Department of Veterans Affairs
• Research funding from Novartis, Johnson & Johnson, Merck, Astellas, Medivation, Progenics
• Member of speakers bureau for Johnson & Johnson and Bayer
• Consultant for Constellation Pharmaceuticals
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Objectives
• Demonstrate knowledge of the paradigm shift in cancer
treatment for Veterans through Precision Oncology.
• Describe VA strategy and future vision for cancer treatment
through a Precision Oncology System of Excellence.
• Understand and describe the scope of partner affiliations of
the VA National Precision Oncology Program to include:
• Explain how the VA-Prostate Cancer Foundation partnership
will establish a System of Excellence for Precision Oncology
that will:
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VETERANS HEALTH ADMINISTRATION
VA National Precision Oncology
Michael J Kelley, MD
National Program Director for Oncology
Chief, Hematology-Oncology, Durham VA
Department of Veterans Affairs
Professor of Medicine
Duke University Medical Center
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Cancer in VA
• In 2010, 46,166 Veterans in VA were
diagnosed with invasive cancer
– The vast majority (97%) were
men
– The most common non-skin
cancers:
– 19% of these Veterans were
black/African American
• VA has a higher cancer incidence
rate than the general US population
• 33% live in rural areas (compared
to 14% in the general population)
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32%
19%
8%
41%ProstateLungColorectalOther
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Our Goal
To ensure that all Veterans, no matter where they live, have
access to cutting-edge cancer therapy
Geographic distribution of living patients diagnosed since 2000
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Transition from Tradition to Precision
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The right treatment for the right patient at the right time.
Precision oncology:
– The evolving understanding of how cancers develop on a molecular level (e.g., DNA
mutations and activation of biochemical pathways)
– Development of targeted therapies that reverse cause of cancer
• Drugs that inhibit activity of proteins that are activated by mutation or gene
expression
– Can ultimately lead to better patient outcomes
Research questions we hope to answer:
– Why does one patient do better than another even though they both have the same type of
cancer?
– What molecular makeup of tumors make a difference?
– Is the answer contained in their personal genetic mutations?
What is Precision Oncology?
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How Precision Oncology Works
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VA initial emphasis
• Metastatic prostate cancer
• Lung Cancer
Identification of molecular biomarker (e.g., DNA
mutation) to guide treatment selection
Clinical Trial of non-FDA approved drug
Off-label use of FDA-approved drug
On-label use of FDA-approved drug
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Veteran Case Study
• Army Veteran in his 40s
• Parent of two young children
• Never smoker
• 8 month history of progressive shortness of breath, cough, and weight loss
• Diagnosed with metastatic lung adenocarcinoma in 2016
• Genetic testing for mutations in the EGFR and ALK genes was normal
• Initial treatment with whole brain radiotherapy followed by carboplatin and pemetrexed chemotherapy showed mixed results.
Baseline PET scan, showing
widespread metastases
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Veteran Case Study
• Next generation sequencing gene panel
showed presence of an abnormal fusion
between the EML4 and ALK genes,
which promotes the cancer
• As a result, in June 2016, chemotherapy
was discontinued and oral crizotinib
precision therapy was started
• He had an excellent response in all sites
and was able to return to work and
school
• In July 2017, switched to alectinib for
asymptomatic progression in his brain
• In Sept 2019, treated with precision IMRT
radiation targeting single brain metastasis
as there were no other sites of cancer
progression and no cancer-related
symptoms.Response to crizotinib between 2 months (top) and 7 months (bottom)
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System of Excellence
• Is Veteran-centric
• Is standardized to adhere to
the most up-to-date best
practices
• Functions as a high-
reliability organization
• Operates at an enterprise-
scale, rather than solely a
local or regional level
• Innovates and drives
innovation
• Precision Medicine
• Implementation Science
• Learning Healthcare System
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Chambers DA, Feero WG, Khoury MJ. Conversion of Implementation
Science, Precision Medicine, and the Learning Health Care System, JAMA
2016
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VHA National Precision Oncology Program
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• Launched in 2016 from regional program whose core service was NGS gene panel DNA sequencing of solid tumor samples
• Standardize molecular testing and analysis across the VA healthcare system• Define and disseminate Precision Oncology best practices
• Molecular Oncology Tumor Board• Patient-specific consultation service
• Reduce disparities e.g. rural health disparities• Generate knowledge on effective, and conversely ineffective therapies• Understand cost and effectiveness of using molecular testing to guide
treatment decisions • Increase opportunities for clinical trial participation• Completed over 10,000 samples as of November 2019
• Nearly all VA oncology practices• Equal utilization for rural Veterans• Results utilized to apply new information (e.g., larotrectinib)• Clinical trial eligibility
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Applied Proteogenomics Organizational Learning and
Outcomes (APOLLO) Consortium VA/DoD/NCI
• Biological information flow: DNA -> RNA -> protein
• Research question: how can information from proteins
improve cancer care?
• Proteins more complex than DNA & RNA
• Simple protein analyses already utilized (e.g., ER in breast
cancer)
• Sophisticated multiplex protein analyses now available and
clinically feasible
• The APOLLO collaboration examining questions of biology,
prognosis, and treatment
• Breast, Prostate, Lung, Ovarian cancers
• Tissue banking
• Multidimensional clinical information
• Poised for rapid clinical application
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Pharmacogenomics Action for Cancer Survivorship
(PHASeR)
• 1 in 3 Veterans is prescribed a medication that is affected by their genetic makeup.
• 90% of Veterans are estimated to have genetic mutations that affect their response to one or more drugs (Chanfreau-Coffinier et al JAMA Network Open 2019).
• Antineoplastic agents impacted, e.g., 5FU in GI cancers• Partnership between VA and Sanford Health Care in Sioux Falls, SD
• $40 million of in-kind germline genetic testing• $10 million to VA for widespread implementation
• DNA testing for common, actionable genetic variants in 8 genes that are known to affect a person’s response to a drug
• Outcomes: operational, utilization and impact on prescribing, efficacy, toxicity and cost-efficacy in VHA
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Tele-Oncology
• Problem: misalignment of supply of (urban) and demand for (rural) oncologists
• Primary Goal: Improve access to care for Veterans with cancer, including timeliness of
cancer care
• VA has well-developed telehealth resources, including national services for radiology,
genetic counseling, and Tele-ICU
• Institute Virtual Cancer Center(s) similar to
NCI-designated Comprehensive Cancer Center
– Providers with specialization in patient’s cancer
type & involved in research
• Improve efficiency and precision of clinical practice
• Initial focus on Medical Oncology in context of
multidisciplinary care
• Targeted service areas
– Smaller VA medical centers
– Larger VA medical clinics (health care centers)
– Smaller VA medical clinics (community-based outpatient clinics)
– Non-VA location, including Community partners and patient’s
home
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A call to action
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• Spread the word about VA’s Precision Oncology System of Excellence
• Contribute to the Culture of Excellence in VA
– VA Providers and Staff
– Medical Education
– Volunteer for VA
• Partnerships in Core Care Delivery Areas
– Tumor gene sequencing
– Molecular Tumor Board
– Clinical Pathways
– TeleOncology to rural areas
– Health Informatics
• Research and Discovery
– Clinical Research
• Access to new drugs and diagnostics
• Funding for clinical trials
– Health Outcomes & Real-World Data
• Novel analyses
• Computing resources
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Precision Oncology Program in Prostate Cancer (POPCaP)
Matthew Rettig, MD
Chief, Hematology-Oncology
VA Greater Los Angeles
Co-Chair, VA POPCaP
Professor of Medicine and Urology
Medical Director, Prostate Cancer Program
David Geffen School of Medicine at UCLA
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Facts about prostate cancer
1Scher et al. PLOS ONE. 2015.Note: Epidemiology data for US only
Incidence 78,5951
Prevalence 76,9601
Deaths 42,6201
Non-metastatic, castration sensitive
Metastatic, castration sensitive
Metastatic, castration resistant
Clinically localized
PSA Recurrence
Non-metastatic, castration resistant
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What is POPCaP
• Precision Oncology Program for Cancer of the Prostate: Goal is
to deliver precision oncology to all Veterans with prostate cancer.
• Partnership between VA and Prostate Cancer Foundation (PCF)
to create system of excellence for prostate cancer in VA
– MOU signed by Secretary in November 2016
– Funding by PCF began in April, 2018 ($50M over five years)
– Clinical emphasis on advanced prostate cancer
– Catalyzed the VHA-supported initiative to create a precision
oncology system of excellence, with VHA funding beginning in FY20
• Consists of:
– Network of VA medical centers with capacity to perform precision
oncology
– Coordinating center
– Data core
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Next Generation Sequencing (NGS) of DNA
• A central premise of POPCaP network is biomarker
based management.
• Results of next generating DNA sequencing of all
Veterans with metastatic prostate cancer is the seminal
biomarker.
– Germline (DNA from non-cancer cells): 10-12% of
patients have hereditary cancer syndrome!!!!
– Somatic (DNA from cancer cells)
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How do we apply precision oncology to ALL Veterans?
1. Increase number and geographic distribution of POPCaP centers.
2. Leverage EMR and VA informatics infrastructure to identify all
patients with prostate cancer
– Patient demographics: location, age, provider, etc
– NGS results
• Does patient have a pathology specimen in VA?
– Disease specific characteristics
• Stage
• Treatment history
3. Increase provider and patient awareness of POPCaP and potential
of NGS
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1. Increase Number of POPCaP Centers of Excellence
Calendar Year 2019 Map
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2. Identify all patients with metastatic prostate
cancer: Role of the Data Core
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VA Medical Center• Clinic notes• Pathology reports• Radiology reports• Lab values
Corporate Data Warehouse (CDW)Austin, TX
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Q: Data Core: How do we Identify All Veterans with
Prostate Cancer?
'castrate resist','castrate resistant','castraion resistant','castrate resistance','castration resist','castrate','castrat','castrate naive','hormone','hormone refractory','hormone sensitive','hormone sensative','castration - resistant'
Semantic Variants'osseous','osteoblastic','osteolytic',‘oligometastatic’‘blastic’Osseous - Lexical'osseus','ossesous','oseous','oseos','ossious','osseious','ossseous','osseous','osseos','ossous','ossoeus','osseuos',Osseoblastic -Lexical'osteblastic','osteoblastic'
'hx','history','pmh','pmhx','h/o'
'diffuse',widespread,‘grossly stable’,‘extensive’,
A: Natural Language Processing
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Prostate Cancer in VA since the advent of the
Electronic Medic Record
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Deceased Living Non-metastatic Metastatic Living metastatic
592,153 488,984 1,017,915 63,222 16,618
PPV of NLP algorithm for identifying metastatic prostate cancer = 0.975
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3. Increase Provider and Patient Awareness
• Use data core to identify biomarker positive patients with metastatic prostate cancer.
• Increase geographic distribution of POPCaP centers
• Provide travel support for Veterans to seek precision oncology clinical trials at nearest POPCaP Center
• Increase awareness
– Provider awareness
– Patient awareness
• Ongoing education
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Veterans with lethal
prostate cancer
Blood for germline
and circulating
tumor DNA
sequencing
Radiographic
directed
biopsy of
metastasis for
tumor
sequencing
Identification of Veterans eligible
for biomarker driven trials
Clinical Trials PARPi for Veterans with
deficient DNA repair
Exome, RNA, and targeted DNA sequencing
What are the specific clinical strategies to deliver
precision oncology?
Immunotherapy for Veterans
with mismatch repair deficiency
Standard of Care
Off label
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1. Standard of Care Therapy
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AD
T
ADT
Pembrolizuma
b
Radiation and
enzalutamide
Biopsy of neck
mass
Sequencin
g reveals
mutMLH1
PSA
Le
vel
In prostate cancer, we use the PSA test to assess for response-to-therapy. Lower is better.
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2. Off Label Use of FDA Approved Drug
Abiraterone
AndrogenDeprivation
Bicalutamide
Carboplatin
Biopsy of liver metastasisP
SA
Leve
l
Sequencing revealsmutBRCA2
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Veterans with lethal
prostate cancer
Blood for germline
and circulating
tumor DNA
sequencing
Radiographic
directed
biopsy of
metastasis for
tumor
sequencing
Identification of Veterans eligible
for biomarker driven trials
Phase II trial of PARPi for
mCRPC
Phase II trial of checkpoint
blockade for mCRPC
Veterans with CDK12-/- or
MSI-high
Veterans with deficient DNA
repair
Exome, RNA, and targeted DNA
sequencing
3. Biomarker driven clinical trial
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Prostate cancer Analysis for Therapy Choice
(PATCH)
mCRPC
Biomarker Acquisition• Germline• Primary• Metatases• ctDNA
CHOMP BRACeDModule
3
Biomarker positive
Biospecimen Repository
Data Core
Module 4
Module 5
Module 6
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A single-arm, open-label, phase II study of CHeckpoint inhibitors
in men with prOgressive Metastatic castrate resistant Prostate
cancer characterized by a mismatch repair deficiency or biallelic
CDK12 inactivation (CHOMP)
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Biomarker = 1. Mismatch Repair Deficiency2. CDK12 inactivation
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BRACeD: BRcA deficient prostate cancer treated with
Carboplatin or Docetaxel
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First lineCarboplatin
First lineDocetaxel
Pro
gres
sio
n –
L1Second lineCarboplatin
Second lineDocetaxel
Ran
do
miz
atio
n
Biomarker = Homologous Recombination Deficiency (HRD) = mutations in:• BRCA1• BRCA2• PALB2
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Transforming the VA: Sustaining POPCaP by
Building on and Expanding Expertise
• Prime Example = Jesse Brown VA (Chicago):
– Initiated Next Generation Sequencing and have identified multiple patients whose treatment plan has been radically modified based on the presence of actionable mutations in nearly half of patients who have undergone sequencing to date.
– Recruited dedicated GU oncologist.
– Initiating clinical trials through the POPCaP network.
– Interface/partner with academic affiliate (Northwestern)
• Planning for a sustainable program.
– Recruiting and supporting young investigators.
• VA Career Development Award Program
• PCF Young Investigator Award program.
• Ongoing education:
– Virtual Molecular Oncology Tumor Board
– AVAHO
– Clinical pathways
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A call to action
• Spread the word about POPCaP
– Discuss with patients and colleagues
• If you provide oncology care, perform NGS on appropriate patients
• Refer patients to POPCaP network centers
• Pharma is encouraged to collaborate
– Drugs: FDA approved and pipeline
– Funding of investigator initiated clinical trials
• VA, DOD, NCI
– Continue to support and expand support for precision oncology.
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If you would like to receive continuing education credit for this activity, please visit:
amsus.cds.pesgce.com
How To Claim CE Credit
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THANK YOU!
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