Course: Nutrition and Metabolism of carbon skeleton.pdf · Pyruvate Acetyl-CoA a-Ketoglutarate...
Transcript of Course: Nutrition and Metabolism of carbon skeleton.pdf · Pyruvate Acetyl-CoA a-Ketoglutarate...
Course: Nutrition and Metabolism
Part (3): Amino Acids & Protein Metabolism
Lecture (3): Carbon Skeleton Catabolism
Dr. Nuha AminMobile: +249910050800
Amino Acid Catabolism
NH3Carbon Skeleton
Urea
Urea
Cycle
H2N C
O
NH2
Amino acid H3+N C
H
R
C
O
O-
energy
Fate of carbon skeleton of amino acids
Carbon skeletons are used for energy.
Amino Acid Catabolism
NH3Carbon Skeleton
Urea
Urea
Cycle
H2N C
O
NH2
Amino acid H3+N C
H
R
C
O
O-
GlucoseKetone bodies
Carbon skeleton fate
• All twenty common amino acids are
converted to only seven compounds: 1. Pyruvate
2. Acetyl CoA
3. Acetoacetyl CoA
4. alpha-Ketoglutarate
5. Succinyl CoA
6. Fumarate
7. Oxaloacetate
Products of Amino Acid Catabolism
• Glucose– Pyruvate
– a-Ketoglutarate
– Succinyl-CoA
– Fumarate
– Oxaloacetate
• Ketone bodies– Acetyl-CoA
– Acetoacetyl-CoA
Amino Acid Classification
Amino acids are grouped into :
1. Glucogenic amino acids produce glucose
2. Ketogenic amino acids produce acetyl-
CoA or acetoacetyl-CoA.
3. Mixed amino acids produce both glucose
and acetyl-CoA or acetoacetyl-CoA
GlucogenicArginine HistidineGlutamateGlutamineProlineAspartateAsparagineSerineGlycineAlanineValineMethionineThreonineCysteine
KetogenicLeucine
MixedPhenylalanineTyrosineTryptophanIsoleucineLysine
Amino Acid Catabolism.
–The fates of ketogenic (red) amino acid carbon
skeletons and glucogenic (yellow) amino acids.
Pyruvate
Acetyl-CoA
a-Ketoglutarate
Succinyl-CoA
Fumarate
Oxaloacetate
Acetoacetate
Glucose
Ile, Met, Val
Gln, Glu, His, Arg, Pro
Leu, Lys, Ile, Phe,
Trp, Tyr
Ala, Ser, Gly ,Trp, Thr, Cys
Asn, Asp
Phe, Tyr Glucose
Glucose
Glucose
Glucose
Five Amino acids give a-Ketoglutarate
• Glutamine
• Glutamate
• Histidine
• Arginine
• Proline
1.Glutamine is
converted to
a-ketoglutarate
H2O
N+H4
glutaminase
NAD(P)+
+ H2O
NAD(P)H + H+
+ N+H4
glutamatedehydrogenase
CH2
CH2
C C H COO-
N H3+
O
H3+N
glutamine
-OOC
H2
CH2
C C H COO-
N H 3+
glutamate
-OOC
H2
CH2
C C
O
COO-
a-ketoglutarate
2.Glutamate is
converted to
a-ketoglutarate
NAD(P)+
+ H2O
NAD(P)H + H+
+ N+H4
glutamatedehydrogenase
-OOC
H2
CH2
C C H COO-
N H 3+
glutamate
-OOC
H2
CH2
C C
O
COO-
a-ketoglutarate
3.Histidine
4.Arginine
5.
Proline
Six Amino acids give Pyruvate
• Alanine
• Serine
• Glycine
• Cysteine
• Tryptophan
• Threonine
1.Alanine is
converted to
pyruvate.H3C C H
N+H3
COO-
alanine
H3C C
O
COO-
pyruvate
a-ketoglutarate
glutamate(NH3)
alanine
transaminase
2.Glycine
3. Serine catabolism
2.Serine is deaminated to pyruvate by serine
Dehydratase.
HO CH2
HC COO
−
NH3+
C COO−
OH2O NH4+
C COO−
NH3+
H2C H3C
H2O
serine aminoacrylate pyruvate
Serine Dehydratase
Serine
Pyruvate
GlycineSerine
hydroxymethyl-
transferase
Serine
dehydratase
4. Cysteine
5. Threonine
Pyruvate
6. Tryptophan gives pyruvate
and acetoacetyl-CoA
Two Amino acids give Oxaloacetate
• Asparagine
• Aspartate
L-asparginase
CH2
C CH COO-
NH3+
O
H2N
CH2
C CH COO-
NH3+
O
-O
H2O
N+H4
asparagine
aspartate
a-ketoglutarate
glutamate(NH3)
aspartateaminotransferase
-OOC
H2
C C COO-
Ooxaloacetate
Breakdown of asparagine
to intermediate
oxaloacetate.
L-asparginase
CH2
C CH COO-
NH3+
O
H2N
CH2
C CH COO-
NH3+
O
-O
H2O
N+H4
asparagine
aspartate
a-ketoglutarate
glutamate(NH3)
aspartateaminotransferase
-OOC
H2
C C COO-
Ooxaloacetate
Breakdown of aspartate
intermediate
oxaloacetate.
COO-
CH3+N
CHH3C
CH3
H
COO-
CH3+N
CHH3C
CH2
H
CH3
COO-
CH3+N
CH2
CH
H
CH3
H3C
COO-
C
CHH3C
CH3
O
COO-
C
CHH3C
CH2
O
CH3
COO-
C
CH2
CH
O
CH3
H3C
C
CHH3C
CH3
O SCoA
C
CHH3C
CH2
CH3
O SCoA
C
CH2
CH
CH3
H3C
O SCoA
CoASH CO2
a-keto acid
dehydrogenase
complexbranched-
chain
amino
transferase
valine
isoleucine
leucine
Acyl-CoA
derivatives
Breakdown of branched amino acids
Leucine
• Is the only purely ketogenic amino acid
• Gives only acetyl-CoA on breakdown
Three Amino acids give Succinyl-CoA
• Isoleucine
• Valine
• Methionine
Methionine, isoleucine and valine
are converted to succinyl CoA
Two Amino acids give Fumarate
and Acetoacetate
•Phenylalanine
•Tyrosine
Phenylalanine and tyrosine
Phenylalanine and tyrosine
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