CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’
-
date post
21-Dec-2015 -
Category
Documents
-
view
224 -
download
4
Transcript of CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’
![Page 1: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/1.jpg)
CONVENTIONAL CANCER THERAPIES
![Page 2: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/2.jpg)
![Page 3: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/3.jpg)
Halsted’s Radical Mastectomy vs ‘Lumpectomy’
![Page 4: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/4.jpg)
![Page 5: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/5.jpg)
3-D structure & schematic of p-glycoprotein
![Page 6: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/6.jpg)
Examples: Methotrexate Eg. Doxorubicin Eg. Cyclophosphoramide, Melphalan
Eg. Vinblastine, paclitaxel
![Page 7: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/7.jpg)
![Page 8: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/8.jpg)
Newer Approaches to Cancer Therapy
Incorporate Predictive Diagnosis
Are Mechanism Based
Designed for Selectivity
![Page 9: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/9.jpg)
Figure 16.2 The Biology of Cancer (© Garland Science 2007)
![Page 10: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/10.jpg)
Figure 16.4a The Biology of Cancer (© Garland Science 2007)
![Page 11: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/11.jpg)
Figure 16.4b The Biology of Cancer (© Garland Science 2007)
![Page 12: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/12.jpg)
Figure 16.5a The Biology of Cancer (© Garland Science 2007)
![Page 13: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/13.jpg)
Figure 16.5b The Biology of Cancer (© Garland Science 2007)
![Page 14: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/14.jpg)
Figure 16.5c The Biology of Cancer (© Garland Science 2007)
![Page 15: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/15.jpg)
Figure 16.5d The Biology of Cancer (© Garland Science 2007)
![Page 16: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/16.jpg)
Therapies Targeting nonTumor Cells
![Page 17: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/17.jpg)
Table 13.3 The Biology of Cancer (© Garland Science 2007)
Targeting the Angiogenic Switch
![Page 18: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/18.jpg)
Tsp-1 Expression Induced by p53
Tsp-1 Expression Inhibited by Ras
An Intrinsic Negative Regulator of Endothelial Cell Populations
![Page 19: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/19.jpg)
![Page 20: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/20.jpg)
VEGF-
R
Inhib
.
PDGF-R
Inhib
.
Synergistic Inhibition of Angiogenesis by the Combination of a Pericyte Inhibitor and an Endothelial Cell Inhibitor
![Page 21: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/21.jpg)
Figure 13.48a, b The Biology of Cancer (© Garland Science 2007)
Radiation Can Have a Greater Effect on Cells of the Microvasculature Than on Tumor Cells
Bone marrow origin of microvasculature cells
![Page 22: CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’](https://reader036.fdocuments.net/reader036/viewer/2022062407/56649d625503460f94a44752/html5/thumbnails/22.jpg)
Figure 13.49 The Biology of Cancer (© Garland Science 2007)