CONTRIBUTORS - Springer978-1-4615-3756-4/1.pdf · CONTRIBUTORS D.S.P. ABDALLA - Dept. of Clinical...
Transcript of CONTRIBUTORS - Springer978-1-4615-3756-4/1.pdf · CONTRIBUTORS D.S.P. ABDALLA - Dept. of Clinical...
CONTRIBUTORS
D.S.P. ABDALLA - Dept. of Clinical Analysis and Toxicology, Faculty of Pharmaceutical Sciences, Univ. of Sao Paulo, Sao Paulo, Brazil
A. ALILA - Inst. of Physiology, Univ. of Helsinki, Siltavuorenpenger 20J, 00170 Helsinki, Finland
M. ALVAREZ-URIA - Dept. de Morfologia Microscopica, Fac. de Biologia y Medicina, Univ. de Oviedo, Julian Claveria, 33006 Oviedo, Spain
A. ANGELI Patologia Medica, Ospedale S. Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano (To)
Y. ANIS - Dept. of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
J. ARENDT - Dept. of Clinical Biochemistry, Univ. of Surrey, Guildford, Surrey GU 25XH, United Kingdom
C. ARCHILI - Di visione di Radioterapia, Nuovo Ospedale S. Gerardo, Monza, Italy
B. ATANASOV Inst. of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, 73 Lenin Ave., 1113 Sofia, Bulgaria
S. BARNI - Divisione di Radioterapia, Nuovo Ospedale S. Gerardo, Monza, Italy
M. BIANCHI - Dipartimento di Farmacologia Chemioterapia e Tossicologia Medica, Facolta di Medicina e Chirurgia, Universita degli Studi, Via Vanvitelli 32, 20129 Milano, Italy
G. BIELLA - Dipartimento di Farmacologia Chemioterapia e Tossicologia Medica, Facolta di Medicina e Chirurgia, Universita degli Studi, Via Vanvitelli 32, 20129 Milano, Italy
D. BLASK - Dept. of Anatomy, Health Science Center, Uni v. of Arizona 85724, USA
C.J. BOIKOWSKI - Dept. of Biochemistry, Univ. of Surrey, Guildford, England
313
G. BARRETTA - Dip. Endocrinologia, Ospedale S. Croce, Cuneo, Italy
F. BRIVIO - 2~ Di visione di Chirurgia, Nuovo Ospedale S. Gerardo, Monza, Italy
T. BUN IVA - Dip. di Scienze Cliniche e Biologiche, Univ. degli Studi, Cattedra di Medicina Interna, Ospedale S. Luigi, 10043 Orbassano (To), Italy
D.M. BURNS - Dept. of Anatomy, Univ. of Arizona, College of Medicina, Tucson, Arizona 85724, USA
D.B. BYLUND Center for Neuro-and Behavioral Biology, Mahido1 University, Salaya, Thailand
A. CAMPA - Dept. of Clinical Analysis and Toxicology, Faculty of Pharmaceutical Sciences, Univ. of Sao Paulo, Sao Paulo, Brazil
G. CANTI - Dipartimento di Farmacologia Chemioterapia e Tossico1ogia Medica, Facolta di Medicina e Chirurgia, Universita degli Studi, Via Vanvite11i 32, 20129 Milano, Italy
D.P. CARDINALI - Univ. de Buenos Aires, Fascultad de Medicina, Dept. de Fisio1ogia, Paraguay 2155 7° Piso cc 243, 1425 Buenos Aires, Argentina
P. CASSONI - Divisione di Ostetricia e Ginecologia, Osp. Mauriziano Umberto 1°, Torino, Italy
G. CATTANEO - Divisione di Radioterapia, Nuovo Ospedale S. Gerardo, Monza, Italy
T.H. CHAMPNEY - Dept. of Anatomy, Texas A & M. Univ., College Station, Texas 77843-1114, USA
H.E. CHULUYAN - Departamento de Fisiologia, Facultad de Medicine., Universidad de Buenos Aires, CC243 , 1425 Buenos Aires, Argentina
I. CICILIATO - Dipartimento di Farmaco1ogia Chemioterapia e Tossicologia Medica, Faco1ta di Medicina e Chirurgia, Universita degli Studi, Via Vanvite1li 32, 20129 Milano, Italy
J. CIPOLLA-NETO - Dept. de Fisiologia, Inst. Sciencias Biomedicas, Univ. San Paulo, Av. Linen Prestes 1524, 05508 San Paulo, Brazil
A. CONTI - Lab. for Experimental Patology, 1st. Cantonale di Patologia, 6604 Locarno, Switzerland
S. COS - Dept. of Anatomy, Univ. of Arizona, College of Medicine, Tucson, Arizona 85724, USA
314
B. COZZI 1st. Anatomia Animali Domestici con Istologia ed Embriologia, Univ. degli Studi, Via Celoria 10, 20133 Milano, Italy
V. CSERNUS - Dept. of Anatomy, Univ. Medical School, Szigeti Str. 12,
H-7643 Pees, Hungary
G. DEMARTINI Dipartimento di Farmacologia Chemioterapia e
Tossicologia Medica, Facolta di Medicina e Chirurgia, Universita degli
Studi, Via Vanvitelli 32, 20129 Milano, Italy
C. DIAZ - Departamento de Morfologia y Biologia Celular, Facul tad de
Medicina, Universidad de Oviedo, Julian Claveria SiN, 33006 Oviedo, Spain
M. EBADI - Dept. of Pharmacology and Neurology, Uni v. of Nebraska,
College of Medicine, 600 South 42nd Street, Omaha NE 68198, USA
D. ESPOSTI - Istituto di Fisiologia Umana II~, Universita degli Studi,
Via Mangiagalli 32, 20133 Milano
F. FRASCHINI Dipartimento di Farmacologia Chemioterapia e
Tossicologia Medica, Facolta di Medicina e Chirurgia, Universita degli
Studi, Via Vanvitelli 32, 20129 Milano, Italy
M. GAVISH - Dept. of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
P. GOVITRAPONG - Dept. of Pharmacology, Lab. of Neurobiology, Univ. of
Nebraska, College of Medicine, 600 South 42nd Street, Omaha NE 68198,
USA
D. S. GROSSO - Dept. of Obstetrics and Gynecology, Uni v. of Arizona,
College of Medicine, Tucson, Arizon 85724, USA
D. GUIDETTI - Divisione di Ostetricia e Ginecologia, Osp. Mauriziano Umberto 1°, Torino, Italy
D. GUPTA - Uni v. of Tubingen, Dept. of Diagnostic Endocrinology, RumelinstraBe 23, D-7400 Tubingen, Germany
G. HELDMAIER - Dept. of Biology, Phillipps University, Lahnberge,
D-3550 Marburg, Germany
S.M. HILL - Dept. of Anatomy, Univ. of Arizona, College of Medicine,
Tucson, Arizon 85724, USA
G.X. HONG - Dept. of Physiology, Faculty of Medicine, Univ. Hong Kong,
Sassoon Road 5, Hong Kong
E.N. ISAEVA Inst. of Experimental Medicine, Academy of Medical SCiences, Leningrad, USSR
315
V. LUCINI - Dipartimento di Farmacologia Chemioterapia e Tossicologia Medica, Facolta di Medicina e Chirurgia, Universita degli Studi, Via Vanvitelli 32, 20129 Milano
L. KANCHEV Bulgarian Acad. of Sciences, Inst. of Biology and Immunology of Reproduction and Development of Organisms, Lenin Ave. 73, 1113 Sofia, Bulgaria
M. KARASEK - Medical Academy, Lab. of Electron Microscopy, Sterlinga 5, 91-425 Lodz, Poland
E.A. KORNEVA - Inst. of Experimental Medicine, Academy of Medical Sciences, Leningrad, USSR
L. LAAKSO Inst. of Physiology Siltavonrenpenger 20J, 00170 Helsinki, Finland
P. P. LEE - Dept. of Physiology, Li Shu Fan Building, Uni v. of Hong Kong, 5 Sasson Road, Hong Kong
A. LEMUS-WILSON - Dept. of Obstetrics and Gynecology, Univ. of Arizona, College of Medicine, Tucson, Arizon 85724, USA
A. LEONE - Dept. of Physical Sciences, Wellcome Research Labor., Langly Court, Beckenham, Kent BR 33BS, U.K.
V. LESNIKOV - Inst. Experimental Medicine, Academy Medical Science of USSR, Pavlov Street 12, 197022 Leningrad, USSR
P. LISSONI - Divisione di Radioterapia, Nuovo Ospedale S. Gerardo, Monza, Italy
L. LOCATELLI Dipartimento di Farmacologia Chemioterapia e Tossicologia Medica, Facolta di Medicina e Chirurgia, Universita degli Studi, Via Vanvitelli 32, 20129 Milano, Italy
J.M. LOPEZ - Departamento de Morfologia y Biologia Cellular, Facultad de Medicina, Universidad de Oviedo, Julian Claveria SIN, 33006 Oviedo, Spain
G.J.M. MAESTRONI Dip. delle Opere Sociali, 1st. Cantonale di Patologia, CH-6604 Locarno, Switzerland
R. P. MARKUS - Dept. of Pharmacology, Inst. of Biomedical Sciences, Univ. of Sao Paulo, Sao Paulo, Brazil
M. MASSOBRIO Divisione di Ostetricia e Ginecologia, Ospedale Mauriziano Umberto 1°, Torino, Italy
M. MASSON-PEVET - URA-CNRS 1332, Neurobiologia des Fonctions Rythmiques et Saisonnieres, Univ. L. Pasteur, Strasbourg, France
316
D.N. Me MURRAY Dept. of Anatomy and Medical Microbiology and A & M University, College Immunology, College of Medicine,
Station, TX 77843-1114, USA Texas
A. MENENDEZ-PELAEZ - Dept. de Morfologia y Biologia Cellular, Fac. de Biologia y Medicina, Univ. de Oviedo, Julian Claveria SiN, 30071 Oviedo, Spain
B. MESS - Dept. of Anatomy, Univ. of Pees Medical School, Szigeti Str. 12, 7643 Pees, Hungary
J . D. MIKKELSEN - Inst. of Medical Anatomy, Dept. B, Uni versi ty of
Copenhagen, Denmark
M. MOLLER Inst. of Medical Anatomy, Dept. B, The Panum Inst.
Blegdamsvej 3, DK-Copenhagen
L.C. MURRIN - Dept. of Pharmacology and Neurology, Univ. of Nebraska,
College of Medicine, 600 South 42nd Street, Omaha NE 68198, USA
G. OSELLA - Dip. di Scienze Cliniche e Biologiche, Univ. degli Studi, Medicina Interna, Osp. San Luigi, 10043 Orbassano (To), Italy
P. PACCOTTI - Dip. di Scienze Cliniche e Biologiche, Univ. degli Studi, Medicina Interna, Osp. San Luigi, 10043 Orbassano (To), Italy
A.E. PANERAI Dipartimento di Farmacologia Chemioterapia e Tossicologia Medica, Facolta di Medicina e Chirurgia, Universita degli
Studi, Via Vanvitelli 32, 20129 Milano, Italy
S.F. PANG Dept. of Physiology, Uni v. of Hong Kong, Li Shu Fan Building, Sasson Road, Hong Kong
F. PELIZZONI - Divisione di Radioterapia - Nuovo Ospedale S. Gerardo, Monza, Italy
S. PERSENGIEW - Bulgarian Acad. of Sciences, Inst. of Biology and Immunology of Reproduction and Development of Organisms, lenin Ave. 73, 1113 Sofia, Bulgaria
P. PEVET - Univ. Louis Pasteur, Lab. de Zoologie et Embriologia Experimentelle, 12 Rue de L'Universite, 67000 Strasbourg, France
P. PHANSUWAN-PUJITO Dept. of Anatomy, Facul ty of Medicine,
Srinakarinvirate University, Bangkok, Thailand
A. PIOVESAN - Dip. Scienze Cliniche e Biologiche, Universita degli
Studi, Medicina Interna, Ospedale S. Luigi, 10043 Orbassano (To), Italy
T. PORKKA-HEISKANEN Inst. of Physiology, Univ. of Helsinki, Siltavuorenperger 20J, 00170 helsinki, Finland
317
J.P. RAVAULT - Inst. Natl. Recherche Agronom, Nouzilly, France
R.J. REITER - Dept. of Cellular and Structural Biology, The Univ. of
Texas, Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas
78284, USA
Z. REKASI - Dept. of Anatomy, Uni v. of Pees Medical School, Szigeti
Str. 12, 7643 Pees, Hungary
S.M. REPPERT - Lab. of Developmental Chronobiology, Children's Service,
Massachusetts General Hospital Boston, Massachussetts 02114, USA
R. RESCALDANI Laboratorio di Microbiologia, Nuovo Ospedale S.
Gerardo, Monza, Italy
A. REVELLI - Di visione di Ostetricia e Ginecologia, Osp. Mauriziano
Umberto 1°, Torino, Italy
M. RIGHI - Center of Cytopharmacology, CNR, 20100 Milano, Italy
S.A. RIVKEES Lab. of Developmental Chronobiology, Massachusetts
General Hosp. and Haward Medical School, Boston, MA 02114,·· USA
C. RODRIGUEZ - Dep. de Morfologia y Biologia Celular, Univ. de Oviedo,
33006 Oviedo, Spain
R. E. ROSENSTEIN - Departamento de Fisiologia, Facul tad de Medicina,
Universidad de Buenos Aires, CC 243, 1425 Buenos Aires, Argentina
F. ROVELLI - Di visione di Radioterapia, Nuovo Ospedale S. Gerardo,
Monza, Italy
F. RUBBOLI - Dipartimento di Farmacologia Chemioterapia e Tossicologia
Medica, Facolta di Medicina e Chirurgia, Universita degli Studi, Via
Vanvitelli 32, 20129 Milano, Italy
T. RUF - Dept. of Biology, Phillipps Univ., Lahnberge, D-3550 Marburg,
Germany
P. SACERDOTE Dipartimento di Farmacologia Chemioterapia e
Tossicologia Medica, Facolta di Medicina e Chirurgia, Universita degli
Studi, Via Vanvitelli 32, 20129 Milano
F. SCAGLIONE Dipartimento di Farmacologia Chemioterapia e
Tossicologia Medica, Facolta di Medicina e Chirurgia, Universita degli
Studi, Via Vanvitelli 32, 20129 Milano
V. SIMMONEAUX - Dept. of Pharmacology, University of Nebraska, College
of Medicine, 600 South 42nd Street, Omaha NE 68198, USA
D. SKENE - Univ. Louis Pasteur, CNRSURA 1332, Lab. de Zoologie, Rue de
l'Universite 12, F-67000 Strasbourg, France
318
B. STANKOV - Dipartimento di Farmacologia Chemioterapia e Tossicologia Medica, Facolta di Medicina e Chirurgia, Universita degli Studi, Via Vanvitelli 32, 20129 Milano, Italy
S. STEINLECHNER Fachbereich Biologie-Zoologie, Phillips Univ. Lahnberge, Karl Von Frisch StraBe, D-3550 Marburg, Germany
D. STENBERG - Inst. of Physiology, Univ. of Helsinki, Siltavuorenpengen
20J, 00170 Helsinki, Finland
A. STIEGLITZ - Dept. of Biology, Phillips Univ., Lahnberge, D-3550 Marburg, Germany
M. TERZOLO - Patologia Medica, Osp. S. Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano (To), Italy
J. TOLIVIA - Departamento de Morfologia y Biologia Cellular, Facultad
de Medicina, Universidad de Oviedo, Julian Claveria SiN, 33006 Oviedo, Spain
M. TORTA - Dip. di Scienze Cliniche e Biologiche, Universita degli
Studi, Cattedra di Medicina Interna, Osp. S. Luigi Gonzaga .. 10043 Orbassano (To), Italy
A. USHEVA - Inst. of Molecular Biology, Bulgarian Academy of Sciences, 73 Lenin Ave., 1113 Sofia, Bulgaria
M.I. VACAS Departamento de Fisiologia, Facultad de Medicine,
Universidad de Buenos Aires, CC 243, 1425 Buenos Aires, Argentina
M.K. VAUGHAN - Dept. of Cellular and Structural Biology, Univ. of
Texas, Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
B. VIVIEN-ROELS - URA-CNRS 1332, Neurobiologie de Fonctions Rythmiques
et Saisonnieres, Univ. L. Pasteur, Strasbourg, France
X.L. WANG - Dept. of Physiology, Faculty of Medicine, Univ. of Hong Kong, Sassoon Rd 5, Hong Kong
D.R. WEAVER Lab. of Developmental Chronobiology, Massachussetts General Hosp. and Harward Medical School, Boston, MA 02114, USA
J. WILKINSON - Dept. of Molecular Science, Wellcome Res. Laboratories, Langly Park, Beckenham, Kent, U.K.
B. WITHYACHUMNARUKUL - Dept. of Cellular and Structural Biology, Univ.
of Texas, Health Science Center, 7703 Floyd Curl Drive, S. Antonio, Texas 78284, USA
M.Y.C. YAN - Dept. of Physiology, Faculty of Medicine, Univ. of Hong Kong, Sassoon Rd. 5, Hong Kong
319
H. YUAN - Dept. of Physiology, Faculty of Medicine, Univ. of Hong Kong,
Sassoon Rd. 5, Hong Kong
Z.H. YU - Dept. of Physiology, Faculty of Medicine, Univ. of Hong Kong,
Sassoon Rd. 5, Hong Kong
N. ZISAPEL - Dept. of Biochemistry, The George S. Wise, Faculty of Life
Sciences, Tel Aviv Univ., Tel Aviv 69978, Israel
320
INDEX
Acetylcholine, 40-44, 72-77 N-Acetylserotonine binding
in breast cancer, 235
N-Acetyltransferase, 8, 29, 38, 39, 54-66, 79-84, 148, 151, 283
activity, 149, 160 assay, 160 diurnal variations, 129 gastrointestinal tract,
127-128, 132-133 harderian gland, 187-
188 Acromegaly
growth hormone rhythm, 293-298
melatonin rhythm, 293-298
ACTH, 254 analogue, 263-271 like peptides, 257-261 and melatonin, 296
Adenomectomy, 294, 296 Adenosin triphosphate, 139 Adrenal, 137-143
adenoma, 294 carcinoma, 294 function, 137 hyperplasia, 298 melatonin binding sites
in, 137-143 melatonin effects on cAMP
and NADH, 173-179 Adrenergic receptors, 35-
66, 140 agonists, 40-46 antagonists, 40-46, 166-
170 Age
and pineal volume, 2 and pineal weight, 2 and 6-sulphatoxymela-
tonin, 303-304 Aldosterone, 263-271
Alsactide, 263-271 Alzheimer's disease, 285 Amphetamine, 5 AMT6s see 6-sulphatoxy
melatonin Analgesia and melatonin
rhythm, 166 Analgesic response and
pinealectomy, 165 Anatomy, comparative,
pineal gland, 1 Antibody
production, 143, 204, 205, 211
response, 202, 203 Antigen T-dependent, 202,
203 Aprotinine, 212 Arginin-vasotocin,
production, 4 Astrocyte, 3, 4 Atropine, 40-46 Autocrine growth factors,
238 Autoimmune disorders, 137
Benzodiazepines, 198 receptors, 47-56
Beta adrenergic blockers, 220
Beta adrenergic receptors, 8, 137
Beta-endorphin, 167, 205, 211-217
N-acetylated, 213 hypothalamic level, 169 immunohistochemical de-
tection, 15-22 intracellular content,
170 in lymphocytes, 169, 170 non acetylated, 213 plasma and serum levels,
169, 170 related peptides, 211
321
secretion, 166 synthesis, 170, 171
Bicuculline, 53-56 Bladder carcinoma, 247 Blood brain barrier, 277 Bone marrow, 226 Boutons en passage, 28 Bovine, pineal gland, 15-22 Breast cancer, 233-240,
267-274 estrogen receptor posi
tive, 233, 240 and 6-sulphatoxymelatonin,
301-304 Bromocriptine, 30, 40, 212 Bromodeoxyuridine, 245-251 Bursa of Fabricius, 254
C1 antigen, immunohistochemical detection, 6
cAMP, effects of melatonin, 173
Capsul, pial opioidergic nerve fibers,
18, 21 peptidergic nerve fibers,
28 Carbachol, 40-46 Cat, pineal gland, 4, 8 Catecholamin receptor site,
140 Catecholaminergic pathway,
48 CCK see cholecystokinin Central rhythm generating
system, 282 CFUs see spleen colony
forming units Chemotaxis, 211 Chemotherapy, 248, 258 Chincilla, non-epiphyseal
pigmented cells, 3 Chlorimipramine, 212 6-Chloromelatonin, 119, 140 Cholecystokinin, 211-217 Cholinergic pathways, 48 Chromatographic analysis,
for detection of pro-enkephalin derivates, 15
Chronobiology and melatonin, 281-292
Circadian rhythms and beta-receptors, 8 and cortisol, 295 and growth hormone, 296 and melatonin, 295-297 and pineal volume, 2 and pineal weight, 2 and pinealocyte organel
les, 2, 6
322
Circulating blood, volume and pineal volume, 2 and pineal weight, 2
Citosine triphosphate, 139 Climatic changes, 159 Clomiphene citrate, 4 Coclear organ, synaptic
ribbons in, 7 Colorectal carcinoma, 247,
274 Concanavalin A, 221 Corticosteroids, 273 Corticosterone, 143 Cortisol
circadian rhythm, 264, 293-298
and melatonin secretion, 293-298
CPON see C-flanking peptide of NPY
CTP see citosine triphosphate·
Cushing syndrome and ACTH, 294, 296 and cortisol, 293-298 and melatonin, 293-298
Cyclic nucleotide levels and melatonin, 173-179
Cyclophosphamide, 273 Cytokine network, 206 Cytotoxic T-cell, 204
DDL1 cells, 241, 242 Denervation, pharmacologi-
cal, 167, 168 Dexetimide, 40-46 Dimethylbenzanthracene,
234-244, 286 Discharge
electrical, 194 tonical, 194
DMBA see dimethylbenzan-thracene
Domperidone, 39, 40 Dopamine, 67-77, 140, 193 Dopaminergic antagonists,
214 Dopaminergic drugs, 214 Dopaminergic receptors,
36-39, 67, 140 agonists, 36-40 antagonists, 36-40
Dynorphin, 205
E2 see estradiol EGF see epidermal growth
factors Ehrich's tumor, 246
Electromagnetic radiation, effect on indoleamine metabolism, 60-66
Electron density fixation
by immersion, 4 by vascular perfusion,
4 pinealocyte, functional
state, 3 Electron microscopy, pineal
gland, mammalian, 2 Electrophysiology, pinealo
cyte, activity, 4 Endogenous opioids, 165-
167, 205 Endorphins, 254
melatonin production, 15 Enkephalins, 254
melatonin production, 15 Environmental signals, 148,
159, 163 EOS see endogenous opioid
system Epidermal growth factors,
238, 239 Epiphyseal cell see pinea-
locytes ER see estrogen receptors Erythroid colonies, 228 Estradiol, 235, 244 Estrogen receptors, 233-240
down regulation, 237, 238 Estrogen sulfotransferase,
238 Estromedins, 238
Fibrosarcoma, 244, 254 c-Flanking peptide of NPY,
28, 29 Follicle-stimulating hor
mone, 254, 263-271 Food restriction, 162 FSB see follicle stimula
ting hormone
GABA, 69-77, 192-195 receptor complex, 35, 47-
56, 192-195, 198 GABAergic antagonists, 214 GABAergic drugs, 214 GABAergic effect on 5-HT
release, 51-56 GABAergic fibers, 69-77 GABAergic synapses and
sleep, 192, 198 GABAergic tone, 194, 198 Ganglia
parasimpatetic, 21
superior cervical, 4, 8, 15, 21, 27, 28, 40
Ganglionectomy, 28 Gerbil, pineal gland, 4, 28 GFA see glial fibrillar
acid protein GH see growth hormone Glial fibrillar acid
protein, immunohistochemical detection, 6
6-Glucuronide melatonin, 241
Glutamate, 193 GnRH see gonadotropin rele
asing hormone Gonadal steroids, effect on
melatonin binding sites, 105
Gonadotropin, 263-271 Gonadotropin releasing hor
mone, 263-271 Growth factors, 238-240,
277 Growth hormone and melato
nin rhythm in acromegaly, 293-298
GTP see guanosin triphosphate
Guanin nucleotides, 91 Guanosin triphosphate, 91,
139 Guinea pig, pineal gland,
3, 4, 15, 18, 28
Habenular commissure, 40 opioidergic nerve fiber,
18,21 Haematopoiesis, 220, 230 Haloperidol, 38, 39, 212,
213 Hamster, pineal gland, 2,
4, 6, 10, 28 Harderian gland, 202
endocrine function, 185-186
interaction with pineal, 185-190
pituitary hormones, 187-188
Hedgehog, pinealocyte, electron density, 3
Hepatocarcinoma, 244 5-BlAA see 5-Hydroxyindole
acetic acid HIOMT see Hydroxyindole-O
methyl transferase Hippocampus, 97-106 Hormonal cycle, 197
signal, 138, 165 stimulation, 138
323
5-HT see serotonin Human chorionic gonadotro
pin, 264 Human pineal gland, opio
dergic nerve fibers, 15, 18
5-Hydroxyindoleacetic acid, 79-84
Hydroxyindole-O-methyltransferase, 79-84, 148, 151
in gastrointestinal tract, 132
6-Hydroxymelatonin, 242 5-Hydroxytryptamine see
serotonin 5-Hydroxytryptophan, 212 5-Hydroxytryptophol, 35, 46 Hypercortisolism, 298 Hyperpolarization, 194-198 Hyperpolarizing effect, 198 Hyperprolactinemia, 268 Hypothalamus, 97, 106, 143,
145 lesions
anterior area, 225-231 posterior area, 225-231
medial basal, 169 paraventricular nuclei,
21, 27, 85-95 SCN receptors in, 87, 119 tuberal nuclei, 21
IFN see interferon IL-2 see interleukin 2 Immune cells, 211 Immune system, 143, 163,
201, 207 circadian control, 219,
283 circannual control, 219,
286 neuroendocrine regula
tion, 225-231 photoperiodic regulation,
219-223, 285 Immunocompetent cells, 205 Immunodepression, 203 Immunoglobulin M, 257 Immunohistochemistry
beta-endorphin, 15, 212 C1 antigen, 6 cholecystokinin, 212 cholineacetyltransferase,
40 cholinesterase, 40 free floating sections
method, 16 glial fibrillary acid
protein, 6
324
leu-enkephalin, 15 met-enkephalin, 15 S-100, 6 serotonin, 4 substance P, 22 vasoactive intestinal
peptide, 21,22 vimentin, 6
Immunologic defense, 230 Immunology
endogenous opioid system, 15
and melatonin, 15 naltrexone, 15
Indoleamine, 140, 147, 153 metabolism, modulation by
interferone, 79-84 neuroimmunological regu
lation of, 57-66 pharmacological regula
tion of, 35-46 rhythm, 148
Innervation, pineal gland cathecolaminergic, 27 neuronal pathways, 15, 27 noradrenergic, 168 opioidergic, 21 parasympathetic, 67 peptidergic, 27, 28, 154,
170 serotoninergic, 27
Interferon, 79-84, 211, 219 action on ACTH, 79
cortisol, 79 GH, 79 insulin, 79 sex hormones, 79 thyroxin, 79
production, 257 Interleukin-2, 84, 273-279
and melatonin secretion, 276-279
production, 203 receptors in human, 206 toxicity, 206
Interstitial cells, 4 and astrocytes, 5, 6 ultrastructure, 5
Intrinsic cells see pinealocytes
Iodomelatonin, 107-116, 117-125, 127-136, 140, 195, 197, 198
Iontophorhesis, 193, 194 Isoproterenol, 8, 79-84,
140
Jet-lag, 281-292
Kirkman Robbins hepatoma, 245
Kynuramine, 241, 242
Lactotrophs, 266 Lamina intercalaris see
pineal gland, deep Lateral geniculate nucleus,
21 intergeniculate leaflet
of, 21 Leu-enkephalin, 205
immunohistochemical detection, 15-22
Leukemia, 246, 247, 254, 258
Levetimide, 40-46 LH see luteinizing hormone LHRH see luteinizing hormo-
ne relasing hormone Liver superoxyde dismutase
activity and pineal 181-183
Locus ceruleus, 225 Lung cancer, 274 Luteinizing hormone, 169,
263-271 Lymphatic organs, 204 Lymphocytes, 4, 211
T-helper, 79, 80, 205-207 human, 134, 170 subsets, 274-279
Lymphokines, 79 activated killer, 206
Lymphomas, 274
Macroglial cells, 6 Magnetic field, 148
effect on indoleamine metabolism, 60-66
Mammary carcinoma, 244 oncogenesis, 244
MCA see methylcolantrene MCF-7 cells, 122, 235-237,
241-242 Median eminence, 119-125 Medulla pons, 97-106 Melanoma, 244, 273
B16, 117 Melatonin
action on adrenal gland, 173 blastogenesis, 219 cAMP, 173-179 cells cycle kinetics,
237 chronobiology, 281-292 circadian rhythm, 89,
281-292 circadian rhythm in
neoplasm, 247, 259, 264, 271, 273-279
cyclic nucleotide levels, 173-179
endogenous opioids, 169-171
estradiol, 237 estrogen metabolism,
237 estrogen receptors, 237 estromedins, 238 gamma-interferon syn-
thesis, 219 gastrointesinal tissue,
131 growth factors, 238,
239 immune response, 137,
143, 204,219-223, 253-261, 273-279, 281-292
NADH-oxidoreductase activity, 173-179
neoplastic growth, 243-251, 253-261
NK activity, 219, 256 prolactin, 263-271 reproductive function,
89, 90, 285 sexual maturation, 99,
100 analgesic action, 166 antiestrogenic action,
238,239 antigonadotrophic ef
fects, 97 antipromotional agent,
234 and behaviour, 163 binding sites, 107-116,
117-125, 137-139, 142, 143, 198
autoradiographic loca-lization, 85-95
avian brain, 110, 112 brain, 109, 118-119 cell lines, 122-124 central nervous system,
107-116, 117 characterization, 86-
94, 107-116, 117-128, 142, 143
comparative distribution, 117-125
diurnal rhythm, 104, 110, 131
down regulation, 104-106
immune system, 107-117 intestine, 127, 132-133
325
Melatonin (continues) intracellular distribu
tion, 110, 120 lymphonodes, 137-143 mammalian brain, 117-
121 medulla pons, 97-106 modulation, 97-106 neoplasms, 117, 121-
122, 235, 248 occupancy, 112 photoperiodic modula
tion, 47-106 G-protein coupling, 85-
95 screening for, 122 signal transduction,
85-95 specificity, 109, 121-
123 testosterone modula
tion, 97-106 biosynthesis, 148, 150,
151, 168 blood levels, 108, 131,
175 circadian rhythm, 60-66,
147-157, 166-169, 276-279, 281-292
in neoplasm, 247-259 circannual rhythm, 144-
155 concentration
in pineal, 137 in plasma, 137, 148,
149, 202, 203 and synaptic ribbons, 10 in gastrointestial tract,
129-133 hypnotic properties, 138,
198 immunomodulatory action,
112-114 oncostatic action, 233-
242, 249 and menstrual cycle, 285 pharmacological effects,
281-292 receptor, see binding
sites salivary levels and
light, 307-311 secretion, 15 serum level
in Acromegaly, 296-297 in cancer, 247-249, 276 in Cushing syndrome,
295-297
326
and light, 307-311 in old subjects, 297
in young subject, 297 sex specific facilitatory
effects, 263-271 sites of action, 89, 90 synthesis regulation, 47-
56 Met-enkaphalins
immunohistochemical detection, 15-22
and melatonin secretion, 15
substance P, release of, 22
Metergoline, 212-217 Methiothepin, 212-217 Methoxyindole, 140 Methoxyharmalan, 242 Methoxytriptamine, 140 Methoxytriptophan, 140 Methoxytryptophol, 35-46,
140, 241, 242 Methylcholanthrene, 244,
245 N-Methylnitrosurea, 233,
244 MF see·~gnetic field Microglial cells, 4, 123 Mole, pinealocyte, electron
density, 3 Monocytoma, 255 Mouse pinealocyte, electron
density, 3 Muscarinic cholinergic re
ceptors, 40-42, 47-56
Muscimol, 212-217
NADH-oxidoreductase activity, 173-179
Naloxone, 165, 166, 168, 170, 211
binding sites, 205 Naltrexone, 226 NAT seeN-acetyltransferase Natural Killer cells, 219,
256 NE see noradrenaline Neoplastic growth, 243-246 Neuroblastoma, 212 Neuropeptide Y, 27-29 Neurotransmitters, action
of melatonin, 67-77 NK see natural killer cells NMU see methylnitrosourea Noradrenaline, 20, 21, 48-
56, 57-66, 140, 167, 168, 170
colocalization with NPY, 29
release, 8, 21, 166
sympatetic, nerve fibers, 8
Norepinephrine see noradrenaline
NPY see neuropeptide Y NRT see thalamus, nuclei
reticulari
Oligodendrocytes, 4 Oncogenesis, 213-240
promotion phase, 234 Opiate
agonists, 212 antagonists, 212 receptors, 211 release, 166
Opiatergic mechanism, 143 Opiatergic pathways, 266 opioid peptides, 211, 225,
230 agonist, 205 antagonist, 170, 204 effects of, 205 and melatonin release,
166 Jl-receptors, 15
Optic nerve, 15 OT see oxytocin Ovarian carcinoma, 244 Oxotremorine, 40-46 Oxytocin, 154
P338 cells, 241, 242 Parachlorophenylalanine,
203, 282 Parenchimal cell tumors,
254 Pars tuberalis see pitui
tary gland PBMC see peripheral blood
mononuclear cells Peptide histidine isoleu
cine immunohistochemical detection, 27-29
Peptidergic nerve fibers, 28
Peptidergic pathways, 48 Perifusion technique, 67-77 Pheripheral blood mono-
nuclear cells, 211-217
PHA see phytoemoagglutinin PHI see peptide histidine
isoleucine Photoperiod, 2, 7, 148,
150, 153, 159, 191, 285
Photoreceptor cells, 1 Photosensitivity, 162
Phytohemoagglutinin, 212 Pilocarpine, 40-46 Pineal gland
N-acetyltransferase, 160, 161
action on immune response, 63-66, 254
interleukin-2, 273-279 neoplastic growth, 243-
251, 253-261 comparative anatomy, 1-13
(see also Anatomy, comparative)
innervation, 15, 21, 27, 28, 67, 154, 168, 170 (see also Innervation)
superoxide dismutase, 181 Pineal tumors, 254-256 Pinealectomy
and immune function, 281, 282
and interleukin-2 production, 219
and neoplastic growth, 243-251, 281
and oncogenesis, 234 Pinealoblastoma, 254 Pinealocytes, 1-13 Pinealocytomas, 254 Pinealomas, 254 Pinealopetal nerve fibers,
27 Pituitary adenoma
ACTH secreting, 294, 296 GH secreting, 294 and melatonin levels, 296
Pituitary gland and adrenal response,
263-271 and beta-endorphin rele
ase, 170 POMC see proopiomelanocor
tin Posterior commissure
opioidergic nerve fibers, 18, 21
Post-synaptic potential inhibitory response, 194
PRL see prolactin Pro-enkephalin, derivati
ves, detection, chromatographic analysis, radioimmunoassay, pineal gland, 15
Progesterone, 263-271 Prolactin, 263-271
action on:
327
immune system, 215 tumor growth, 244
serum levels, 254 Prolactinoma, 245 Proopiomelanocortin, 257 Propranolol, 8, 39, 40, 59,
167, 170, 202, 203, 220, 282
Prostatic adenoma, 256 Prostatic carcinoma, 245,
247 Prostatic hyperplasia, 247 G-proteins, 90, 91 PVT see hypothalamus, para
ventricular nucleus
Quipazine, 212-217
Rabbit, pinealocyte distribution, 3
Radioimmunoassay for ACTH, 294 for cortisol, 294 for growth hormone, 294 for melatonin, 20, 21,
294, 308 for pro-enkephalin
derivate, 15 for 6-sulfatoxymelatonin,
301, 302 Renal carcinoma, 273, 274 Reproductive system, 162,
191 Reserpine, 162 Retina, 7, 15, 142, 202 Rhythm autonomous in CNS,
197 RNA-polymerase II
activity, 138, 142, 143 synthesis, 140
Rodents thalamus, neuronal tra
cing studies, 27 Rosette-like structures, 9
SCG see ganglia, superior cervical
SCN see suprachiasmatic nucleus
Scopolamine, 40-46 Seasonal rhythm, 159-163
and pineal volume, 2 and pineal weight, 2 pinealocyte organelles
size, 6 Serotonin, 4, 48, 57-66,
72-77, 79-84, 140, 170, 193
fibers, 67 receptors, 140
328
agonists, 32-40, 214 antagonists, 32-40
Serotoninergic antagonists, 214
Serotoninergic drugs, 214 Sex
and pineal volume, 2 and pineal weight, 2
Sheep, pineal gland, 2, 27-29
Sleep-wake cycle, 193, 282 Sodium valproate, 212, 213 SNAT see N-acetyltrasferase Spleen, morphology and lym-
phoprolipherative activity, 219-223
Squirrel, pineal gland, 2, 3
non-epiphyseal pigmented cells, 3
Streptavidin-biotin technique, 16, 28
Stress, endocrine reactions to, 253
Stria medullaris thalami opioidergic nerve fibers,
18, 21 Substance P,
enkephalins, colocalization, 22
receptors, 47-56 6-Sulphatoxymelatonin, 301-
304 Sulpiride, 38-39, 301-304 Superoxide dismutase, 181-
184 Suprachiasmatic nucleus,
15, 17, 48, 57, 85-95, 119, 165, 196
Sympathectomy, bilateral, 8 Synaptic ribbons, 7-9, 16 Synaptic spherules, 9, 10
Tamoxifen, 233, 237 Teratoma, 254, 255 Testosterone, 264-271 TGF alfa see trasnforming
growth factors alfa TGF beta see trasforming
growth factors beta Thalamus,
nuclei, 193, 198 nuclei reticulari, 140 pattern, 198 pinealopetal fibers, 27
Thymus, 138 involution, 227 and pineal lymphoyd
tissue, 254 weight, 143, 227, 228
Thyroid stimulating hormone, 263-271
Thyrotropin releasing hormone, 263-271
Transforming growth factor alfa, 238, 239
Trasforming growth factor beta, 277
TRH see thyrotropin releasing hormone
TSH see thyroid stimulating hormone
Vasoactive intestinal peptide, 20-22, 29, 47-56, 154
and N-acetyl-transferase, 21
function, 29 immunohistochemical de
tection, 21 opioidergic neuropeptides
release of, 21-22 receptors, 47-56
Vasopressin, 154 VIP see vasoactive inte
stinal peptide
Walker carcinoma, 254
Zeitgerbers, 159, 196, 283
Yoshida tumor, 246
329