Contents
Transcript of Contents
T H E J O U R N A L O F T H E A L Z H E I M E R ’ S A S S O C I A T I O N
Volume 10, Issue 2 March 2014
CONTENTS
Featured Articles135 Microvascular network alterations in the retina
of patients with Alzheimer’s disease
Carol Yim-lui Cheung, Yi Ting Ong,
M. Kamran Ikram, Shin Yeu Ong, Xiang Li,
Saima Hilal, Joseree-Ann S. Catindig,
Narayanaswamy Venketasubramanian, Philip Yap,
Dennis Seow, Christopher P. Chen, Tien Yin Wong
143 Time course of brain volume changes in the
preclinical phase of Alzheimer’s disease
Charlotte Bernard, Catherine Helmer,
Bixente Dilharreguy, Helene Amieva,
Sophie Auriacombe, Jean-Francois Dartigues,
Michele Allard, Gwena€elle Catheline
152 Simulating effects of biomarker enrichment on
Alzheimer’s disease prevention trials:
Conceptual framework and example
Jeannie-Marie S. Leoutsakos, Alexandra L. Bartlett,
Sarah N. Forrester, Constantine G. Lyketsos
162 Global brain hypoperfusion and oxygenation in
amnestic mild cognitive impairment
Jie Liu, Yong-Sheng Zhu, Muhammad Ayaz Khan,
Estee Brunk, Kristin Martin-Cook,
Myron F. Weiner, C. Munro Cullum,
Hanzhang Lu, Benjamin D. Levine,
Ramon Diaz-Arrastia, Rong Zhang
171 Accounting for functional loss in Alzheimer’s
disease and dementia with Lewy bodies:
Beyond cognition
Joanne M. Hamilton, David P. Salmon,
RemaRaman, Lawrence A.Hansen, EliezerMasliah,
Guerry M. Peavy, Douglas Galasko
Alzheimer’s & Dementia (ISSN 1552-5260) is published bi-monthly by Elsevier, 360 Park
May, July, September, and November. POSTMASTER: send address changes to Alzheim
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179 Personality and risk of Alzheimer’s disease:
New data and meta-analysis
Antonio Terracciano, Angelina R. Sutin,
Yang An, Richard J. O’Brien, Luigi Ferrucci,
Alan B. Zonderman, Susan M. Resnick
187 Infantile exposure to lead and late-age cognitive
decline: Relevance to AD
Syed Waseem Bihaqi, Azadeh Bahmani,
Gehad M. Subaiea, Nasser H. Zawia
196 Increased risk of dementia in people with
previous exposure to general anesthesia: A
nationwide population-based case–control
study
Chia-Wen Chen, Che-Chen Lin, Kuen-Bao Chen,
Yu-Cheng Kuo, Chi-Yuan Li, Chi-Jung Chung
205 Evaluation of memory endophenotypes for
association with CLU, CR1, and PICALM
variants in black and white subjects
Otto Pedraza, Mariet Allen, Kyle Jennette,
Minerva Carrasquillo, Julia Crook, Daniel Serie,
V. Shane Pankratz, Ryan Palusak, Thuy Nguyen,
Kimberly Malphrus, Li Ma, Gina Bisceglio,
RosebudO. Roberts, John A. Lucas, Robert J. Ivnik,
Glenn E. Smith, Neill R. Graff-Radford,
Ronald C. Petersen, Steven G. Younkin,
Nil€ufer Ertekin-Taner
214 Implications of early treatment among
Medicaid patients with Alzheimer’s disease
David S. Geldmacher, Noam Y. Kirson,
Howard G. Birnbaum, Sara Eapen,
Evan Kantor, Alice Kate Cummings,
Vijay N. Joish
Contents continued on next page
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Contents continued
225 Diagnosing Alzheimer’s disease: A systematic
review of economic evaluations
Ron L.H. Handels, Claire A.G. Wolfs,
Pauline Aalten, Manuela A. Joore,
Frans R.J. Verhey, Johan L. Severens
238 ADO: A disease ontology representing the
domain knowledge specific to Alzheimer’s
disease
Ashutosh Malhotra, Erfan Younesi,
Michaela G€undel, Bernd M€uller,Michael T. Heneka, Martin Hofmann-Apitius
Perspectives
247 Rethinking the Food and Drug
Administration’s 2013 guidance on developing
drugs for early-stage Alzheimer’s disease
Lon S. Schneider
Review Article
251 Alzheimer’s disease in the human eye. Clinical
tests that identify ocular and visual information
processing deficit as biomarkers
Lily Y.L. Chang, Jennifer Lowe, Alvaro Ardiles,
Julie Lim, Angus C. Grey, Ken Robertson,
Helen Danesh-Meyer, Adrian G. Palacios,
Monica L. Acosta
Short Report
262 Microdosing of scopolamine as a
‘‘cognitive stress test’’: Rationale and
test of a very low dose in an at-risk
cohort of older adults
Peter J. Snyder, Yen Ying Lim,
Rachel Schindler, Brian R. Ott,
Stephen Salloway, Lori Daiello,
Christine Getter, Catherine M. Gordon,
Paul Maruff
Association Pages
268 Alzheimer’s Association Update
Online Exclusives
e27 Clinical characterization of a presenilin
1 mutation (F177S) in a family with very
early-onset Alzheimer’s disease in the
third decade of life
Lucrezia Hausner, Jakob A. Tsch€ape,Hans Peter Schmitt, Frank Hentschel,
Tobias Hartmann, Lutz Frolich
e40 Deaths in the United States among personswith
Alzheimer’s disease (2010–2050)
Jennifer Weuve, Liesi E. Hebert, Paul A. Scherr,
Denis A. Evans
e47 2014 Alzheimer’s disease facts and figures
Alzheimer’s Association
ISTAART Members and individual subscribers will have free access to two special online issues (February and October)
this year. Read the Journal (including these new, supplemental issues), register online, and sign up for alerts at www.
alzheimersanddementia.org.
Optic Disc
retinal opti
of both reti
disease pro
& Retinal Vasculature (Peter J. Snyder, 2013). Spalted box elder platter with pyrography, and superimposed
cal coherence tomography (OCT) image of artist’s (right eye) retinal vasculature and optic disc. OCT imaging
nal vasculature and neuron-containing cell layers may lead to new non-invasive biomarkers of early Alzheimer’s
gression.