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Quick PATH BytesShashidhar Venkatesh Murthy

A/Prof & Head of PathologyCollege of Medicine & Dentistry

Congenital WBC Disorders

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Congenital WBC disorders: Leucocytosis:

Idiopathic Neutrophilia. Increased neutrophils. Asymptomatic. Leucopenia:

Ethnic or Benign familial Neutropenia. (Jews, Blacks & Arab) Cyclical Neutropenia. – cyclical variation in WBC counts. Kostmann’s syndrome: Congenital agranulocytosis – lack of G-CSF

severe neutropenia & severe infections. Felty’s syndrome: Rheumatoid arthritis & severe neutropenia. Severe Combined Immunodeficiency: absent T Lymphocytes.

WBC Function disorders: Chronic Granulomatous Disease:

Defective microbicidal function. Lazy leukocyte syndrome.

“Everyone is a genius. But if you judge a fish by its ability to climb a

tree, it will spend its whole life believing it is stupid…!”

- Albert Einstein