Conference: Focus on the Hepatitis B Virus

1www.apaslstc-armenia2015.com

ASIAN PACIFIC ASSOCIATION FOR THE STUDY OF THE LIVER

SINGLE TOPIC CONFERENCEFOCUS ON THE VIRUS HEPATITIS B

3-6 OCTOBER 2015 YEREVAN, ARMENIA

SCIENTIFIC PROGRAMM

2 www.apaslstc-armenia2015.com

Dear colleagues, ladies and gentlemen!

On behalf of the Ministry of Healthcare of the Republic of Armenia and me personally I cordially welcome the participants of the International Conference: “Focus on the Hepatitis B”.

Viral Hepatitis is polyetiologic group of diseases, which is responsible for 1,5 million deaths

each year. Most of them are associated with HBV-infection. Around 600 million people, or every 11-th person in the world are currently living with HBV and HCV infection. They are at serious risk of developing the liver cirrhosis and hepatocellular carcinoma. That is why, viral hepatitis is recognized as a global public healthcare problem in the world.

I am glad, that this Conference, organized on the initiative of Armenian Hepatological Forum, has unified the leading specialists and doctors of various fields not only from Armenia and CIS countries, but also from Europe, Asia and the USA.

In medicine, as in any other area it is impossible to achieve any progress without cooperation. Moreover, one can hardly imagine the modern medicine without the international experience in evidence-based medicine. In this context collaboration with specialists, advanced medical centers, laboratories and international associations could have a tangible contribution in finding the most efficient ways for the solution of the pressing issues of Hepatology.

I wish constructive dialogue and fruitful work to all the participants of the Conference.

Minister of Healthcare Republic of Armenia,MD, professorArmen Muradyan


Dear Colleagues,

On behalf of the Organizing Committee, it is a great honor and pleasure for me to invite you to the Asian Pacific Association for the Study of the Liver (APASL) Single Topic Conference (STC) on HBV in Armenia. The conference will be held in October 3-5, 2015, in Yerevan. This is the first time that an APASL event will take place in this new region.

The conference will focus on all aspects of the management of Hepatitis B Viral Infection and will include the important topics of epidemiology, virology and immunology of HBV Infection as well as optimal current and future treatment approaches for patients with HBV Infection. It will be one of the sequential APASL conferences on HBV with the aim to invite all experts in the field from the different regions of the world, to present the latest research and clinical data. The Scientific program of the conference is supported by a key international advisory group.

Yerevan is regenerated community based on the ancient city Erebuni which was founded by Urartian King Argishti I (r. ca. 785–753 BC) in 782 BC. It was built on the top of a hill called Arin Berd overlooking the Arax River. Yerevan is one of the world’s oldest continuously inhabited cities. The city is a home to dozens of museums, art galleries, and libraries as well as to the largest Armenian Church in the world, the Cathedral of Saint Gregory the Illuminator, opened in 2001 when the entire Armenian nation had celebrated the 1700th anniversary of the establishment of the Armenian Church and the adoption of Christianity as a state religion in Armenia. Yerevan is as old as its traditions and culture.

Yerevan is also famous for its Brandy (Cognac) where there is a leading Brandy Company with its main brand name “Ararat”.

Our guests will enjoy Armenian cuisine as well as the cuisine of other countries in the finest restaurants and cafes.

There is a large exhibition market next to the Republic Square where you can buy Armenian national souvenirs, handcrafts, clothes and accessories. October is the best season to visit Armenia. The weather is mild; it is warm and mostly sunny. It is called “gold” season with its beautiful autumn shades so called Saryan’s colors. There are many Public Holidays in October. The main is Erebuni-Yerevan which is an event dedicated to the capital of Armenia.

We hope you will enjoy this conference as well as your stay in Armenia, the country with an extensive and rich history, culture and amazing traditions and hospitality.

We are looking forward to see you in Armenia.With kindest regards

President of APASLSTC 2015 in Armenia

Hasmik Ghazinyan MD, PhD

Co-ChairmanGagik Hakobyan MD, PhD

Secretary GeneralAra Asoyan MD, PhD


ACKNOWLEDGEMENTS

SPONSORS

PLATINUM SPONSOR


SCIENTIFICPROGRAMM


10:00-20:00 Registration

09:00-09:15 Opening Ceremony

09:15–11:55

Session 1 – HBV: Overview of Epidemiology and Burden of DiseaseChairs: Osuma Yokosukao, Sang Hoon Ahn, Ara Asoyan, Gayane Melik-Andreasyan, Tsaxik Vardanyan

09:15–09:30 The Changing Epidemiology of HBV in AsiaSang Hoon Ahn, South Korea

09:30-09:45 The Changing Epidemiology of HBV in MongoliaOidov Baatarkhuu, Mongolia

09:45-10:00 The Changing Epidemiology of HBV in EuropePierre Van Damme, Belgium

10:00-10:15 The Changing Epidemiology of HBV in North AmericaRay Kim, USA

10:15-11:55 Epidemiology of HBV Infection in CIS countries

10:15-10:25 Epidemiology of HBV Infection in RussiaVladimir Chulanov, Russia

10:25-10:35 Epidemiology of HBV Infection in UkraineLarisa Moroz, Ukraine

10:35-10:45 Epidemiology of HBV Infection in BelarusIgor Karpov, Belarus

10:45-10:55 Epidemiology of HBV Infection in GeorgiaDavid Metreveli, Georgia

10:55-11:05 Epidemiology of HBV Infection in MoldovaIuliana Lupasco, Moldova

11:05-11:15 Epidemiology of HBV Infection in KazakhstanAlexander Nersesov, Kazakhstan

11:15-11:35Epidemiology of HBV Infection in ArmeniaHasmik Ghazinyan, Gayane Melik-Andreasyan,Gayane Sahakyan, Armenia

11:35-11:55 Discussion

11:55-12:25 Coffee break

Saturday, October 3

Sunday, October 4


12:25-13:30Session 2 - VIROLOGY AND IMMUNOPATHOGENESISChairs: Richard Moreau, Tigran Davtyan, Robert Gish, Irakli Rtskhiladze, Ara Babloyan

12:25-12:40Covalently Closeed Circular (ccc) DNA is the only reason,unable clear HBV; May need Immunological Atttack?Masao Omata, Japan

12:40-12:55 HBV Genotypes and Core and Pre-core MutationsRobert G Gish, USA

12:55-13:10 Interactions Between HBV, Host Immunity and the liverTigran Davtyan, Armenia


13:30-14:30 Lunch

14:30-16:30Session 3 - NATURAL HISTORYChairs: Massao Omata, Oidov Baatarkhuu, Narine Pashinyan, David Metreveli, Ray Kim

14:30-14:45Natural History of Chronic Hepatitis B and Predictors of Disease Progression (viral and host)Diana A.Payawal, Philippines

14:45-15:00 Occult HBV Infection: Clinical SignificanceSaeed Hamid, Pakistan

15:00-15:15 HBV - HCCKim Ray, USA


15:30-15:50 Acute - on - Chronic liver failure (ACLF)Shiv Kumar Sarin, India

15:50-16:05 HBV - ACLFRichard Moreau, France

16:05-16:20The Role of Non-invasive Markers and Imaging in Staging liver Disease in Chronic HBV InfectionSalimur Rahman, Bangladesh


16:30-17:00 Coffee Break


17:00-18:00SESSION 4 - TREATMENT INDICATIONS AND OPTIONSChairs: Hasmik Ghazinyan, Diana A. Payawal, Larisa Moroz, Vladimir Chulanov, Gamal Shiha

17:00-17:20 HBV: Treatment Indications and Therapeutic End-pointsShiv Kumar Sarin, India

17:20-17:40 Is Clearance of HBsAg and cccDNA a Realistic Target?Robert G. Gish, USA


17:55-18:00 First Day Closing

Faculty Dinner including Social Program

09:00-11:00SESSION 5 - CURRENT TREATMENT FOR CHBChairs: Manoj Kumar Sharma, Pierre Bedossa, Saeed Hamid, Igor Karpov, Violeta Sargsyan

09:00-09:15

Treatment of Patients with CHB with Pegylated Interferon: Clinical Significance of HBV DNA and HBsAg Quantitative TestingAlaaeldin Ibrahim, Egypt

09:15-09:30 NAs as First-line Therapy for CHBGamal Shiha, Egypt

09:30-09:45 Monitoring and Management of NAs failuresVladimir Chulanov, Russia

09:45-10:00Risk factors of HCC during nucleic acidtreatment on chronic hepatitis BOsamu Yokosuka, Japan

10:00-10:20 Management of CHB patients with Decompensated CirrhosisChay Dai, Taiwan

10:20-10:40Can Cirrhosis be Really Reversed? A focus on the Parenchymal Extinction NodulePierre Bedossa, France


11:00-11:30 Coffee Break

Monday, October 5


11:30-13:30SESSION 6 - CHB in SPECIAL POPULATIONSChairs: Barjesh Sharma, Mamun –Al-Mahtab, Gagik Hakopyan, Luliana Lupasco, Chia –Yen Dai

11:30-11:50 Management of CHB in the Immunosuppressed PatientsNarina Sargsyants, Armenia

11:50-12:10 Management of CHB in ChildrenMamun- AL- Mahtab, Bangladesh

12:10-12:30 Management of CHB in PregnancyHasmik Ghazinyan, Armenia

12:30-12:50Management of CHB in Co-infected Patients (HBV - HCV ),and (HBV - HIV )Violeta Sargsyan, Armenia

12:50-13:10Management of CHB in Renal Disease and RenalFailure PatientsBarjesh Sharma, India


13:30-14:30 Lunch

14:30-16:00

SESSION 7 – INTERACTIVE CASE STUDY DISCUSSIONSON THE TREATMENT OF CHB (DIFFICULT- TO- TREAT CASE SCENARIOS) AND WHO-POLICYChairs: Robert G. Gish, Narina Sargsyants, Antons Mozalevskis, Alexander Nersesov, Aregnaz Mkhitaryan

14:30-14:45 Case-Based_Management HBV reactivationRobert Gish, USA

14:45-15:00UNUSUAL CASE OF HIGHLY REPLICATIVE HBV VIRUSINFECTION WITH EXTRAHEPATIC MANIFESTATIONSNarina Sargsyants, Armenia

15:00-15:15

Hepatitis B reactivation after pagylated interferonplus ribavirin in chronic HBV/HCV coinfectedTaiwanese patientChia-Yen Dai, Taiwan

15:15-15:30Case of HBV related chronic liver disease presentingas acute hepatitisMamun- AL- Mahtab, Bangladesh

15:30-15:45 Managment of chronic Hepatitis DAlexander Nersesov, Kazakhstan

15:45-16:05 WHO - PolicyAntons Mozalevskis, WHO



16:15-18:00

SESSION 8 - WHAT IS ON THE HORISON FOR TREATMENT OF CHB? NEW TARGETS FOR HBVChairs: Gerardo Enrique Guilleen, Pavel Bogomolov, Salimur Rahman, Alaaeldin Ibrahim, Hasmik Ghazinyan

16:15-16:35 Treatment of HBV Beyond the GuidelinesManoj Kumar Sharma, India

16:35-16:55 Other New TherapiesRobert G Gish, USA

16:55-17:10Myrcludex B, an NTCP- specific Inhibitor of HBV and HDV EntryPavel Bogomolov, Russia

17:10-17:20 Immune Based Therapies for CHBGerardo Enrique Guilleen, Cuba


17:40-18:00 Meeting Closing

GALA DINNER INCLUDING SOCIAL PROGRAM

17:00-19:00 Satellite SymposiumRoche

October 6


INVITEDSPEAKERS


DR. SHIV KUMAR SARIN

Prof. S.K. Sarin, is a Senior Professor of Hepatology and Director, Institute of Liver and Biliary Sciences (ILBS). He is an astute clinician, a pioneer in clinical protocol innovations, a gifted teacher, front-line clinical researcher with great insights into basic sciences, an educationist and above all an enthusiastic learner.

Dr. Shiv Kumar Sarin obtained his MMBS degree with seven gold medals (1974), his MD in General Medicine (1978) from Rajasthan University and his DM in Gastroenterology from the AIIMS in 1981. He moved to the G.B. Pant Hospital of Delhi University in 1983 and became the Head of Gastroenterology in 1997. He is currently the Professor & Head, Department of Hepatology and Founder Director, Institute of Liver & Biliary Sciences, New Delhi first of its kind in Asia.

His research interests include Portal hypertension, Chronic hepatitis B, C and liver cancer. He has made outstanding contribution in the pathogenesis and management of bleeding in liver diseases. His seminal contributions to understanding portal hemodynamics, non-cirrhotic portal hypertension and approach for Primary Prevention of Variceal Bleeding by band ligation and endotherapy based on “Sarin’s Classification of Gastric Varices” have significantly improved the management protocols. His proposal of changing the nomenclature of “Hepatitis B carrier” to “Chronic HBV Infection” is widely accepted. He has helped define two new disease entities; “Portal Biliopathy” and “Acute-on-Chronic Liver Failure (ACLF)”.

He has published over 350 original articles in prestigious journals like New England Journal of Medicine, The Lancet, Annals of Internal Medicine, Gastroenterology and Hepatology, AJP, JCI. He has edited 9 books. He led the development of five major global guidelines for the Asian Pacific Association for the Study of the Liver (APASL). These are widely quoted and practiced.

He was awarded the Padma Bhushan in 2007 for his overall seminal contributions to the Medical field in India. He has received Shanti Swarup Bhatnagar Award, Third World Academy of Medical Sciences (TWAS) International Prize, Om Prakash Bhasin Award, Ranbaxy Medical Sciences Award, Dhanvantri Medical Award and the “Best Teacher” Award, Amrut Mody Research Foundation Award, Hoechst Om Prakash Foundation Award, Fogarty International Fellowship, Dr. Dharamveer Datta Memorial Oration of ICMR, Olympus J. Mitra Award, Rotary Award, Rashtriya Samman Puraskar of IEDRA, Lifetime Acheivements Award of Delhi Govt., Knoll Oration Award of ISG, Netaji Oration of API, Mike Mosnal Lecture of SAGES, South Africa, Dr. V.R. Khanolkar Oration of ICMR, Silver Jubilee Research Award of MCI, Dr. Y.S. Row Award of INSA, FICCI Award, Dr. Kunti Om Prakash Award of ICMR, Bhagwan Mahaveer Award, DRC Gold Medal Oration, Malaysia Liver Foundation Award and the Most Distinguished Physicians from India by American Association of Physicians of Indian origin, USA.


He is the founding Chief Editor of a prestigious international Journal, Hepatology International (Springer International).

Dr. Sarin served as the President of Asian Pacific Association for the Study of the Liver (APASL) and now as Chairman of the steering committee.

He was nominated to lead the Medical Council of India (MCI) as the Chairman of the Board of Governors, 2010-2011. He developed with other BOGs the “Vision 2015” document for Medical Education in India. He introduced far reaching reforms in medical education and health sciences.

He has started the “Yellow Ribbon Campaign” for hepatitis prevention in India in 1998, which has become a national movement now.

Dr. S K Sarin has been instrumental in the establishment through the Govt of Delhi, the Institute of Liver and Biliary Sciences (ILBS) in India, which is also the first Deemed to be University in the field of Liver and Biliary Diseases globally.


BARJESH CHANDER SHARMAProfessor, Department of Gastroenterology Govind Ballabh Pant Hospital,

New Delhi-2, India EXPERIENCE IN GASTROENTEROLOGY1. Senior Resident (Hepatology) – 2 years PGIMER, Chandigarh.2. DM Resident (Gastroenterology) – 3 years SGPGIMS, Lucknow3. Senior Research Associate (Gastroenterology) – 13 months GB Pant Hospital, Delhi, PGIMER, Chandigarh4. Assistant Professor (Gastroenterology) – 33 months PGIMER, Chandigarh5. Associate Professor (Gastroenterology) – 5 years and 3 months GB Pant Hospital, Delhi6. Professor (Gastroenterology) – 1/4/2005 – Present GB Pant Hospital, Delhi. RESEARCH EXPERIENCE1. Papers published – 1972. Submitted for publication – 83. Papers presented/abstracted – 237 4. Conferences/Workshops attended – 56

JOURNAL EDITOR, MEMBER AND OFFICE BEARER OF SCIENTIFICCOMMITTEES AND SOCIETIES

1. Secretary-General cum Treasurer of APASL.2. Member of Steering Committee of APASL.3. Chairman of Guidelined Committee of APASL4. Member of Executive Council of APASL.5. Member of Indian Society of Gastroenterology.6. Member of Society of Gastrointestinal Endoscopy.7. Member of Indian Association for Study of Liver Diseases.8. Member of Asian Pacific Association for Study of the Liver9. Editor- Journal of Gastroenterology and Hepatology 2004; 19: Supplement - Postgraduate course and current reviews in Hepatology, 14th Biennial Conference of Asian Pacific Association for the study of the Liver10. Assistant Editor for Journal “Hepatology Intennational”11. Member of Editorial Board of “World Journal of Gastroenterology”. 12. Member of Editorial Board og J Gastroenterol Hepatol.13. Member of Editorial Board of Journal of Clinical and Experimental


MANOJ KUMAR SHARMA

Current position: Additional Professor, Institute of Liver & Biliary Sciences,New Delhi, India (April 2014 – Now)

Past Positions: Associate Professor, Institute of Liver & Biliary Sciences,New Delhi, India (April 2010 – March 2014)

Advanced Endoscopy Fellow, Beth Israel Deaconess Medical Center,Harward Medical School, Boston, MA, USA (July 2014 – Nov 2014)

Assistant Professor, Institute of Liver & Biliary Sciences, New Delhi, India(June 2008 – March 2010)

Assistant Professor, Department of Gastroenterology at G B Pant Hospital,New Delhi India. (June 2006 – May 2008)

PUBLICATIONS ORIGINAL ARTICLES: 100PUBLICATIONS: REVIEWS: 50

REVIEWER

1. GASTROENTEROLOGY2. HEPATOLOGY INTERNATIONAL3. ANTIVIRAL THERAPY4. J HEPATOLOGY5. Indian J of Gastroenterology

EDITORIAL BOARD AND ASSOCIATE EDITOR1. HEPATOLOGY INTERNATIONAL


OSAMU YOKOSUKAM.D., Ph.D.

EDUCATION1969 – 1975 M.D Chiba University School of Medicine

RESEARCH AND PROFESSIONAL EXPERIENCES1975–1976 – Resident in Chiba University Hospital1976–1978 – Medical staff, Kimitsu Central Hospital1978–1980 – Clinical Observer, Clinical assistant, Research Fellow: (Royal Free Hospital School of Medicine, London University, Prof.S.Sherlock, Prof.BH Billing)1978–1985 – Research Fellow: First Department of Medicine,Chiba University (Prof.K.Okuda, Dr.M.Omata)1983 – Research Fellow (Fox Chase Cancer Center, Dr.J.Summers)1985–1992 – Assistant Professor, First Department of Medicine, Chiba University1985–1986 – Research Fellow: Biology Department, National Cancer Center Institute (Dr.S.Nishimura)1992–2006 – Lecturer, First Department of Medicine, Chiba University2006– Professor and Chairman, Department of Medicine and Clinical Oncology, Post graduate school of Medicine, Chiba University2009–2011 – Vice Director of Chiba University Hospital2009–2014 – Secretary General cum Treasurer of APASL2011–2013 – Chiba University Councilor2012– Professor and Chairman,Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine2013–2015 – Dean Chiba University Graduate School of Medicine2014–2015 – President Elect of APASL2015– President of APASL1986– Degree: Doctor of Medical Science (Chiba University)

MEMBERSHIP Japanese Gastroenterology Association, Japan Association For the Study of Liver Disease, International Association for the Study of Liver Disease, etc Asian Pacific Association for the Study of Liver Disease, Associate Editor: J Gastroenterol Hepatol (1989–1993) Associate Editor: Liver International (2003–2007) Associate Editor: Hepatology Research (2006–) Associate Editor: Hepatology International (2007–) MAJOR FIELD OF INTERST Viral Hepatitis, Hepatocellular Carcinoma


SAEED SADIQ HAMID

Dr. Saeed Sadiq Hamid is The Ibne Sina Professor of Medicine and Chairman, Department of Medicine at The Aga Khan University, Karachi, Pakistan. He graduated from King Edward Medical College, Lahore in 1981, and has been affiliated with AKU since 1990. He completed his postgraduate training in Medicine and Gastroenterology in the UK, and in Hepatology at University of Texas Southwestern Medical School, Dallas, USA.

His research interests include Viral Hepatitis and Acute Liver Failure. He has been the recipient of basic and clinical research grants, including clinical trials. He has a total of 135 peer reviewed publications and three book chapters to his credit, and currently serves as an associate editor for Hepatology International, the official journal of APASL.

Dr. Hamid has been a Member of the Executive Council, Asian Pacific Association for the Study of the Liver, 2006-2010, and currently also serves as President, Pakistan Society for the Study of Liver Diseases. He has been a long serving member of the WGO Guidelines and Publications committee and also a member of many guideline development groups of the APASL, as well as WHO.


MAMUN AL-MAHTAB

Dr. Mahtab graduated from Mymensingh Medical College, Bangladesh in 1995. He did MSc in Gastroenterology from University of London, UK in 1998 and subsequently did MD in Hepatology from Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh in 2006. He is a Fellow of the American College of Gastroenterology.

Dr. Mahtab is working as an Associate Professor at the Department of Hepatology, Bangabandhu Sheikh Mujib Medical University. He has conducted several clinical trials, which have been presented at international conferences and published in regional and international peer-reviewed journals.

He has compiled four books, namely “Liver: A Complete Book on Hepato-Pancreato-Biliary Diseases”, published by Elsevier, “Comprehensive Text Book on Hepatitis B”, published by Jaypee, “Fatty Liver Disease” and “Hepatitis Management Update” published by McMillan and “Text Book of Hepato-Gastroenterology” published by Jaypee.

He is serving in the Editorial Boards of several international journals in the fields of Hepatology and Gastroenterology including Euroasian Journal of Hepato-Gastroenterology (journal of Euroasian Gastroenterological Association), Journal of Clinical and Experimental Hepatology (journal of Indian Association for the Study of the Liver), World Journal of Hepatology, Hepatitis Monthly, Journal of Global Infectious Diseases to name a few.

He has received awards for scientific works from different major international bodies including American Association for the Study of Liver Diseases (AASLD), World Gastroenterology Organization (WGO), Asian Pacific Association for the Study of the Liver (APASL), International Association for the Study of the Liver (IASL), Euroasian Gastroenterological Association (EGA), Japan Society of Hepatology (JSH), Indian National Association for the Study of the Liver (INASL), Turkish Hepato-Biliary-Pancreatology Association (HEBIPA), Asia-Pacific Primary Liver Cancer Expert (APPLE) Association and Association of Physicians of Bangladesh (APB).

He has more than 110 international and over 35 national publications, more than 160 international and over 35 national conference abstracts and over 90 international conference talks to his credit, of these the most prestigious one being «Blumberg Oration 2015» conferred by Kalinga Gastroenterology Foundation, India.


Dr. Mahtab is member of the APASL Working Parties on hepatitis B, Hepatitis C, acute on chronic liver failure (ACLF) and liver fibrosis.

He is the Secretary General, Association for the Study of the Liver, Dhaka, Bangladesh (the national Hepatology Association of Bangladesh). He is also the founder Secretary General of Viral Hepatitis Foundation Bangladesh, a non-government service provider and research organization in Bangladesh. He is a Member of European Association for the Study of the Liver (EASL) and a Life Members of Asian-Pacific Association for the Study of Liver (APASL) and Indian National Association for the Study of the Liver (INASL).


OIDOV BAATARKHUUMD., PhD

Position: Professor and ChairmanInstitution: Department of Infectious Diseases School of Medicine, Mongolian National University of Medical SciencesProfessor O.Baatarkhuu graduated from the Mongolian National Medical

University and obtained his degree in Doctor of Medicine with commendation in 1994. He has received his PhD degree at the Postgraduate School, Health Sciences University of Mongolia in 2006. He is currently Professor of Medicine, Head of Department of Infectious Diseases, School of Medicine, Mongolian National University of Medical Sciences and General Expert on Infectious Diseases of Ministry of Health, Mongolia.

He has completed his postdoctoral Fellowship in Hepatology at the Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea between 2007–2008. He did second overseas Clinical Research Fellowship in Hepatology at the Department of Internal Medicine III, AKH Hospital, University of Vienna, Austria in 2012. Also currently he has completed as a Clinical Research Fellow in Hepatology at the Storr Liver unit, Westmead Millennium Institute for Medical Research, University of Sydney, Australia. He has also been a Visiting Professor at the Victorian Infectious Diseases Laboratory, Melbourne, Australia in 2014.

Professor O.Baatarkhuu is an Executive Council Member of APASL, Member of CEVHAP, President of the Mongolian Association for the Study of the Liver Diseases, Executive Director of the Mongolian Infectious Diseases Physicians, General Expert of Infectious Diseases of Ministry of Health, Mongolia, Board member of Mongolian Society of Virology, Academic Member of Scientific Committee of the National Center for Communicable Diseases, Mongolia and Chairman of the Scientific Committee for the APASL-STC 2012 in Mongolia.

Professor O.Baatarkhuu is a key investigator in more than 10 international and national trials on antiviral treatment of chronic hepatitis B and C. He has received numerous local, national and international research awards.

He has been extensively involved in research in the fields of viral hepatitis and hepatocellular carcinoma and he is currently working on the natural history of hepatitis B in Mongolia.

Professor O.Baatarkhuu has published more than 125 international and local papers. He also has spoken nationally and internationally on viral hepatitis and chronic liver diseases including hepatocellular carcinoma.

Research interest: Epidemiology, prevention, molecular virology, and treatment of viral hepatitis B, C, D and Liver cirrhosis and HCC.


SALIMUR RAHMAN

Professor Salimur Rahman is a veteran Hepatologist of Bangladesh and at present working as professor of Hepatology Bangabandhu Sheikh Mujib Medical University which is the only medical university of this country. He is one of the founders of the discipline in this country. He is a co-editor of 1) “Liver: A Complete Book on Hepato-Pancreato-Biliary Diseases” and 2) “Comprehensive Text Book of Hepatitis B” published by Elsevier and Jaypee respectively. Professor Rahman has over 100 publications in international and regional journals. He is Editor-in-Chief of Euroasian Journal of Hepato-Gastroenterolgy, the official publication of Euroasian Gastroenterological Association and Viral Hepatitis Foundation Bangladesh. He is the Member of the Editorial Board of Hepatology International. He is the current President of Association for the Study of the Liver, Dhaka, Bangladesh – the National Association of Hepatologists of the country and the President of Association of Physicians of Bangladesh – the premier platform of specialist physicians of Bangladesh. He is also the founder Chairman of Viral Hepatitis Foundation Bangladesh. He served as member national committee for Hepatitis B virus in Bangladesh and served as executive committee member of Asian Pacific Association for the study of the Liver (APASL). He is the current president of South Asian Association for the Study of Liver (SAASL). Professor Salimur Rahman is a leading interventionist of Bangladesh and has pioneered the transformation of Hepatology from a theoretical to an interventional super-specialty in this country. He is a senior faculty member of the Department of Hepatology, Bangabandhu Sheikh Mujib Medical University. He is a Fellow of Bangladesh College of Physicians and Surgeons, Royal College of Physicians of Edinburgh and Royal College of Physicians of Dublin.


DIANA ALCANTARA PAYAWALMD, MSc, FPCP, FPSG, FPSDE

Graduate • Fellowship in Hepatology, Interventional Sonology and Digestive Endoscopy and Molecular Biology, Department of Gastroenterology, University of Tokyo, Tokyo Japan through a scholarship Ministry of Education, Japanese Government (MOMBUSHO).• Fellowship in Gastroenterology and Digestive Endoscopy Unit, Digestive Endoscopy of University of Santo Tomas, Manila, Philippine.• Master/Diploma, Tropical Medicine and Hygiene, Degree School of Tropical Medicine, Mahidol University, Bangkok, Thailand through scholarship Southeast Asia Ministry of Education (SEAMEO).• Residency Training in Internal Medicine Department of Internal Medicine, Cardinal Santos Medical Center.• Faculty of Medicine and Surgery University of Santo Tomas, Manila, Philippines.

Academic Position• Asst. Professor Faculty of Medicine and Surgery Univerisity of Santo Tomas• Asst. Professor Faculty of Medicine Fatima Medical Univerisity Hospital

Past and Present Position:1. Head, Digestive Health Unit, Fatima Medical Center 2011-present2. Asst Head Section of Gastroenterology, Cardinal Santos Medical Center 2011–present3. Chairman, Training Committee, Cardinal Santos Medical Center 2001–present4. Chairman, Hospital Research Committee, Fatima Medical University Hospital5. Executive Council Board, Asia Pacific Study of the LIVER (APASL) 2011 20156. President, Hepatology Society of the Philippines 2012–2014 (March)7. President, Philippine Society of Gastroenterology 2010–20118. Regional Member IC-HEP 2014–present9. Editorial Board, Hepatology International 2015–present10. Steering Committee, Asian Pacific Study of the Liver (APASL) 2014–201511. Advisory Board, APASL–Japan 201612. Advisory Board APASL–Turkey 201513. Course Director, First Radiofrequency Ablation workshop and Hands-on Training for Liver Cancer, CSMC, 201514. Core Committee, Guidelines on Hepatitis B Screening and Treatment, Hepatology Society of the Philippines, 2014


15. Core Committee, Guidelines on Colon Cancer Screening, Philippine Society of Gastroenterology 201416. Core Committee, Guidelines on Hepatitis B Screening and Treatment, Hepatology Society of the Philippines, 201417. Chairman, Committee on Advocacy, APASL 2013-201518. President, Asia Pacific Study of the LIVER (APASL) Single topic Symposium Liver Cancer 2013, Cebu 19. Philippine Heart Center-Institution Ethics Review Board 2014 up to resent20. Internatonal Advisory Board Asia Pacific Study of the LIVER (APASL) 201321. Associate Editor, Philippine Journal of Medicine22. International Reviewer, Hepatology International23. Co-founder Asia Pacific Digestive Cancer Alliance 2010


PROF GAMAL SHIHAMD, MSc, FPCP, FPSG, FPSDE

Affiliations:Prof. Internal Medicine. Dept. GI and liver unit; Mansoura faculty of medicine.Head of the Egyptian Liver Research Institute And Hospital (ELRIAH).2014−2015 − Study Principal InvestigatorStudy Title: A phase III, Randomized, Open-Label Study, for the Treatment of Egyptian Adults with Chronic HCV Infection Genotype 4.Site: Specialized Medical Hospital, Mansoura University.

2013−2014 − Study Principal Investigator Study Title: A Phase III Randomized, Open-Label Study for the Treatment of Egyptian Adults with Chronic Genotype 4 HCV Infection.Site: Egyptian Liver Research Institute And Hospital (ELRIAH)

2009−2011− Study Principal Investigator Study Title: Randomized, placebo-controlled, multi-center study to assess the efficacy and safety of a new drug in thrombocytopenic subjects with hepatitis C virus (HCV) infection who are otherwise eligible to initiate antiviral therapy. Site: Specialized Medical Hospital, Mansoura University.

2008−2009 − Study Principal Investigator Study Title: DFPP for Chronic Hepatitis C Virus.Site: Specialized Medical Hospital, Mansoura University.

Recent Published papers− Wahid Doss, Gamal Shiha. Sofosbuvir Plus Ribavirin for Treating Egyptian Patients With Hepatitis C Genotype 4. Journal of Hepatology 2015.− Shiha G, Samir W, Seif S, EldesokyA, Soliman R. The CC allele at rs12979860 IL28B is associated with higher hepatic fibrosis in HCV atients with genotype 4. Accepted Poster. Hepatology 2014, Supplement 1, no. 1843. − Gamal E. Esmat, Gamal Shiha, Rabab F. Omar, Mohamad, Hassany, Radi Hammad, Marwa Khairy, Waleed Samir, Reham Soliman, et al. Sofosbuvir plus Ribavirin in the Treatment of Egyptian Patients with Chronic Genotype 4 HCV Infection. Accepted Poster. Hepatology 2014, Supplement 1, no. 959. − Rakhi Maiwall, Shiv K. Sarin, Chandan K. Gamal Shiha, Utility Of A Modified PIRO (Predisposition, Injury, Response, Organ Failure) Model For Predicting Kidney Failure In Patients With ACLF- A Multinational Cohort Study. Accepted Poster. Hepatology 2014, Supplement 1, no. 1843. No. 578.


ALAAELDIN IBRAHIMM.D

Prof. of Medicine, Former chief of GI/Liver unit, Faculty of Medicine, University of Benha, Egypt.

Have been graduated from Qasr El Ayny Medical School, Cairo University on 1982. Have been awarded Master Degree and Degree of Doctorate from University of Benha, Egypt. Have been trained in gastroenterology and hematology at Cairo University, University of Benha and Maady military hospital, Egypt. Have part of his postgraduate and post-doctorate training at the Royal Free hospital, and St Mark’s Hospital; London, UK. Have been invited as a speaker and moderator in many national and International meetings. Awarded the degree of full Professor of Medicine in 1996. Had the post of Chief of Liver/GI division University of Benha, the director of endoscopy unit and the director of the internal medicine University hospital, Benha, Egypt. Have been visiting many medical recognized centers globally. Have been elected as executive council member (ECM) for APASL and the vise-Chair of public health committee on 2012 till now. Have co-Chaired the two APSASL STC on Liver fibrosis that have been held in Cairo, Egypt on 2008 and 2014. He is a member in many local, regional and International societies. He is a member of APASL, EASL, ESGE and ASGE. Have many local and international publications in the field of hepatology and gastroenterology. His main interests are, NAFLD, liver fibrosis, liver emergencies and viral hepatitis C.


CHIA-YEN DAIM.D. PhD

FACULTY: Professor, School of Medicine, College of Medicine, Kaohsiung MedicalUniversityProfessor, Institute of Graduate Medicine, College of Medicine, KaohsiungMedical UniversityProfessor, Institute of Clinical Medicine, College of Medicine, KaohsiungMedical University

EDUCATION:M.D. Kaohsiung Medical University, Kaohsiung, TaiwanMaster in Medical Science, Institute of Medical Science, Kaohsiung MedicalUniversityPhD. in Medical Science, Institute of Medical Science, Kaohsiung MedicalUniversity

LICENSURE AND CERTIFICATION:National Medical Board of Republic of ChinaBoard of Internal Medicine, R.O.C.Board of Gastroenterology, R.O.C.Board of Critical Care Medicine, R.O.C.Board of Digestive Endoscopy R.O.C.Board of Environmental and Occupational Medicine, R.O.C.

POSTDOCTORAL TRAINING1996−1998 − Gastroenterology training, Division of Hepatology, Departmentof Medicine, Kaohsiung Medical University Hospital, Taiwan 1998 − Research Fellow, Division of Hepatology, Kyoto University, Kyoto1998−1999 − Critical Care Medicine training, Department of EmergencyMedicine, Kaohsiung Medical University Hospital, Taiwan 1999−2001 − Occupational Medicine training, Department of OccupationalMedicine, Kaohsiung Medical University Hospital, Taiwan MAJOR RESEARCH INTERESTS:1. Molecular epidemiology of hepatitis C virus infection in Taiwan2. Treatment of patients with acute and chronic hepatitis C3. Molecular epidemiology of GB virus C/hepatitis G virus infection in Taiwan4. Molecular epidemiology of TT virus infection in Taiwan5. Treatment of chronic hepatitis B patients


MAJOR ADMINISTRATIVE RESPONSIBILITIES:2007 − now Chief, Department of Occupational Medicine, Kaohsiung Medical University Hospital 2009 − now Chief, Health Management Center, Kaohsiung Medical UniversityHospital 2008 − now Professor, School of Medicine, College of Medicine, KaohsiungMedical University2012 − now Vice Secretary General, Gastroenterology Society of Taiwan(GEST)

PublicationMore than 180 SCI papers (first author: 52; corresponding author: 15)published.


RAY KIMMD

W. Ray Kim, MD, is Professor and Chief in the Division of Gastroenterology and Hepatology at Stanford University School of Medicine. Prior to assuming this post in November 2013, Dr. Kim was Professor of Medicine at Mayo Clinic College of Medicine.

Dr. Kim earned his medical diploma at Seoul National University in Korea.

After residencies in medicine at Seoul National University and University of Arkansas for Medical Sciences, he underwent subspecialty training in gastroenterology and hepatology as well as receiving a Certificate of Added Qualification in liver transplantation, both at Mayo Clinic in Rochester, MN. He also holds a Master in Science Degree in patient oriented research from Seoul National University and a Master in Business Administration from University of Pennsylvania.

Dr. Kim’s research interest has been in epidemiology and outcomes and

comparative effectiveness studies in viral hepatitis and end stage liver disease. His research has been funded by several NIH grants, one of which is credited for the seminal achievement of producing the Model for End Stage Liver Disease or the MELD score. MELD has been rapidly accepted in the past decade as a standard by which to assess severity of liver failure in patients with end stage liver disease.

Dr. Kim has been active in several professional societies and not-for-profit

organizations. He is the current Treasurer and a member of the Governing Board at the American Association for the Study of Liver Disease (AASLD). He is also a founding trustee of the AASLD Foundation. He has been an Associate Editor of Hepatology and served on a number of editorial boards.

Dr. Kim practices general and transplant hepatology with emphasis on

viral hepatitis, liver cancer and pre-and post-operative care of liver transplant recipients. As a Division Chief as well as full-time faculty at Stanford University, he is actively engaged in the education of undergraduate and medical students, residents and fellows as well as junior faculty members.


ROBERT GISHMD, DSc, Professor

Director of Center for Hepatobiliary Disease and Abdominal Transplantation (CHAT) University of California, San Diego, CA, USA

More than 20 years, Professor Robert Gish is a leader expert in a hepatological practice, particularly, in hepotological function disorders, liver transplantology, viral hepatitis, liver cancer. More than 22,000 patients with different hepathological disorders have a chance to improve their quality of life by getting appropriate treatment by him. Moreover, Mr. Gish implement an enhanced programme for prevention, screening and treatment of hepotological diseases, hepatitis B in South Africa and Vietnam for which he has been honored with the «Humanitarian of the Year» Award.

Dr. Robert Gish graduate from Medical University of Kansas city, after which he continued his fellowship residency at the Gastroenterology and Hepatology at the University of California, Los Angeles.

He is a member of the American Association for the Study of the Liver, the American Gastroenterological Association, the American Society of Transplant Physicians, and the International Liver Transplant Society, and etc. Professor Gish has published more than 500 original articles, reviews, abstracts, and book chapters regarding all aspects of liver disease and transplantation.


RICHARD MOREAUMD

Degree:1983: M.D., University of Paris

Academic Appointments:1996 − Date Director of Research (Senior Scientist) at the French NIH(Inserm) Grade 2 (1996), Grade 1 (2009), Outstanding (2014)1996−2004 − Head of group in the Lebrec’s lab (successively at Inserm Unit24 and 481), Clichy, France2005 − Date Head of Team (Complications of cirrhosis) at UMR_S 773,Centre de Recherche Biomédicale Bichat-Beaujon CRB3, Inserm andUniversité Paris Diderot, Clichy/Paris, France.2013 − Chairman, UMR_S 773, Centre de Recherche Biomédicale BichatBeaujon CRB3, Inserm and Université Paris Diderot, Clichy/Paris, France.2014 − Date Vice-Chairman, UMR_S1149, Centre de Recherche surl’Inflammation CRI, Inserm and Université Paris Diderot, Clichy/Paris, France.2013 − Date Co-Chairman, with Prof. Shiv Sarin (Institute of Liver and BiliarySciences, ILBS, New Delhi, India) of an International Associated Laboratoryentitled “Associated Laboratory of Transcriptomics and Metabolomics forLiver Diseases”.

Hospital Appointments:1983−1996 Physician in Intensive Care Units of Ile-de-France1996−Date Consultant in Liver Unit, Beaujon Hospital (successively Headedby Profs J-P Benhamou, S Erlinger, D Valla, and F Durand), AssistancePublique Hôpitaux de Paris (APHP), Clichy, France

Society Membership:− American Association for the Study of Liver Diseases− European Association for the Study of the Liver− French Speaking Society of Intensive Care Medicine− French Association of the Study of the Liver (Scientific Committee, 2005 2007)− International Ascites Club (Scientific Committee, 1994−2003)

Awards:− 2009: Colombian Society of Gastroenterology− 2014: Czech Society of Hepatology− 2014: Award Scientific Excellence (Inserm)

Editorial Activities:− 1997−2001: Associate Editor, Gastroentérologie Clinique et Biologique− 2001−2008: Co-Editor: Gastroentérologie Clinique et Biologique− 2002−2006: Editorial Board, Hepatology− 2007−2009: Editorial Board, Journal of Hepatology− 2007−2009: Associate Editor, Liver International


− September 2010-Date: Editorial Board, Hepatology− 2010−2014: Associate Editor, Journal of Hepatology− 2015−2018: Senior Editor, Journal of Hepatology French Organization of Research:− 2008-Date: In charge of the Liver Branch at the Inserm Institute called “Pathophysiology, Metabolism, Nutrition” (Head, Prof C. Boitard).− 2010-Date: Elected as Member of the Council advising the Dean of the Faculty of Medicine, University Paris Diderot, Paris− 2013-Date: Member of the Steering Committee (SC) at the “Département Hospitalo-Universitaire” (DHU) UNITY (for Addressing Unmet Needs through Innovation in HepaTology and GastroenterologY), Beaujon Hospital, APHP, Clichy, France− 2012 − Date: Partner of the “Laboratoire d’Excellence (Labex)” Inflamex, ComUE Sorbonne Paris Cité, Paris, France.

International Steering Committes (SCs):− June 2009 − Date: Member of the SC of the Consortium EASL-CLIF (for Chronic Liver Failure); 2011: Principal Investigator of the CANONIC Study on Acute-on-Chronic Liver Failure.− 2010−2013: Member of the SC of the Special Interest Group on Portal Hypertension of the American Association for the Study of Liver Diseases.

Scientific Production:− 289 Peer-Reviewed publications (PubMed, June 2015),of which 207 original

articles, 82 Review Articles or Editorials; h-index: 51− Editor of 1 book− 24 book chapters,− 200 Invited conferences (70% outside France), > 250 communications in International meetings.


PIERRE BEDOSSAM.D. PhD

Pierre Bedossa is Professor of Pathology at the University Paris-Diderot, France. He is currently Head of the Department of Pathology, Physiology and Nuclear Medicine at the Groupe Hospitalier Paris Nord. He is Chairman and Head of the Department of Pathology at Beaujon Hospital, Paris FRANCE.

Pierre Bedossa is specialized in liver pathology. He is the leader of the METAVIR group and of the FLIP pathology consortium. He has produced new scoring systems in chronic hepatitis and NAFLD. His research interests have focus on dynamic of liver fibrosis, the cellular mechanisms leading to progression and regression, and evaluation methods of liver fibrosis.

From 2001 to 2013, he was appointed as director of the research team “pathophysiology of liver diseases” (CNRS UMR 8147) and he is currently the team leader of “cirrhosis and liver cancer group” at the Center for Biomedical Research, INSERM U773, Paris, France. He was a member of the editorial board of Journal of Hepatology (1991−1996), Hepatology (2001−2006), Journal of Pathology (since 2002) and Associate editor of Virchows Archiv of Pathology (2003−2012). He has published more than 350 original articles in peer-reviewed journals and 16 Book chapters. Pierre Bedossa is the current president of the European Society of Pathology.


ANTONS MOZALEVSKIS

Dr. Antons Mozalevskis is currently working as a Medical Officer at the WHO Regional Office for Europe in Copenhagen, Denmark. He is responsible for all viral hepatitis-related activities at the Regional Office and technical support to the Member States in the Region.

He completed his medical training and residency in Family Medicine at Riga Stradins University, Latvia. He worked as a clinician for 7 years and was involved in a number of civil society and professional organisations active in the field of HIV/viral hepatitis prevention and research. In 2012 − 2014, he completed the European Programme for Intervention Epidemiology Training (EPIET) and received a Master Degree in Applied Epidemiology from the National School of Public Health in Madrid, Spain.

Dr. Mozalevskis has over 10 years of experience in the field of Public Health, HIV and viral hepatitis, including being a member of Latvian National Coordination Committee for HIV, STI and Viral Hepatitis in the past, and a member of several regional and international expert networks.


VAN DAMME PIERRE

Pierre Van Damme is full professor at the University of Antwerp, Faculty of Medicine and Health Sciences. He chairs the Vaccine & Infectious Disease Institute (VAXINFECTIO, University of Antwerp); VAXINFECTIO is a consortium of three research units within the university: the Laboratory of Medical Microbiology (LMM), the Laboratory of Experimental Hematology (LEH), and the Centre for the Evaluation of Vaccination (CEV). It is recognized as “Centre of Excellence” of the University of Antwerp and functions as WHO Collaborating Centre for the WHO European Region for the control and prevention of infectious diseases.

The CEV was founded in 1994 by Pierre Van Damme. The centre conducts research in 5 main areas: (1) (sero-)epidemiology of infectious diseases; (2) economic evaluation of public health interventions and mathematical modelling of infectious diseases; (3) assessment of protective efficacy and effectiveness of vaccines; (4) injection and diagnostic device research; (5) kinetics of vaccine-induced antibodies, including passive transfer of maternal antibodies.

Pierre Van Damme gained his MD from the University of Antwerp in 1984. He was recruited in 1985 to work on the epidemiology and prevention of hepatitis B in institutions for the mentally retarded. He subsequently obtained post-graduate degrees in health and economics, the evaluation of human corporal damage, and a master degree in occupational health. He obtained his PhD in epidemiology and social medicine in 1994 from the University of Antwerp, Belgium.

In 2000, he was appointed Professor at the Faculty of Medicine and Health Sciences, University of Antwerp − he teaches infectious diseases and vaccinology in the Faculty of Medicine and Health Sciences as well as in the Faculty of Pharmacy and Biomedical Sciences. He has authored more than 300 peer-reviewed papers and is on the editorial board of several scientific journals that focus on the study of vaccines and vaccine-preventable infectious diseases. Professor Van Damme was awarded with the Research Award of the University of Antwerp, and in 2000 with the Belgian Social Medicine Award “Jean Van Beneden” for his work on the introduction of universal hepatitis B immunization programs. In May 2014, he was awarded with the prestigious Bill Marshall award of the ESPID society.

Since 1994, he has served as the executive secretary of the Viral Hepatitis Prevention Board, a group of international experts dealing with topics on prevention and control of viral hepatitis. His current research projects at the University are focused on the epidemiology and prevention of vaccine-preventable infectious diseases, such as hepatitis A, hepatitis B, diphtheria, pertussis, varicella, rotavirus, measles, HSV, influenza, and HPV. His research also concerns occupational health, youth health and preventive health for sex workers. Since 1985 he has conducted more than 300 vaccine trials within the trial unit of Centre for the Evaluation of Vaccination.


He has been for more than 10 years a regular advisor for national and international organizations, including the Flemish Vaccination platform, the National Immunization Technical Advisory Group, and the World Health Organization (European Regional Office and Headquarters). He has been appointed as chairman of the European Technical Advisory Group of Experts on communicable diseases and vaccines for the WHO European Region (ETAGE).


GERARDO ENRIQUE GUILLEN NIETO

Degree: Master of Science Organic chemist, 1986, Odessa University. Ukraine. Ph.D. on Biological Sciences, Havana University, 1995 Senior ResearcherCurrent Position: Biomedical Research Director Centro de Ingeniería Genética y biotecnología Havana, Cuba

Other relevant information:146 papers published on vaccinology and drug developmet (molecularbiology, immunology, preclinical and clinical evaluation). 41 patents granted or filled in Europe, USA, Japan and other relevantcountries. Vaccine development experience on hepatitis, dengue, meningitis, pertussis,combine vaccines and cancer vaccines.Member of the Expert Vaccine Committee of the Ministry of Science andTechnology of Cuba.Member of the Cuban Academy of Science elected for the period 2012 –2016.

Awards:1993−2014 − 42 annual awards of Cuban Academy of Science for scientific results.2002−2010 − 8 awards of the Ministry of Health for a best published scientific papers of the year.2010 − Award World Office Intellectual property2008 − Award 485 Anniversary of Havana City for upstanding results on Science.2005 − “C.J. Finlay Medal” of the Cuban State Council, awarded for upstanding results on Science2003 − TWAS (Third World Academy of Science) award on Biology.


SANG HOON AHNM.D., Ph.D.

1 − Department of Internal Medicine, 2 − Institute of Gastroenterology3 − Brain Korea 21 Project for Medical Science Yonsei University College of Medicine, Seoul, Republic of Korea.

Sang Hoon Ahn, M.D., PhD, is a Professor of Yonsei University College of Medicine and a director of Referral Centre, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea.

He has completed a Postdoctoral Fellowship at Liver Research Centre in Brown Medical School, USA (2001−003). His career has been advanced during his sabbatical years at Victorian Infectious Diseases Reference Laboratory (VIDRL), WHO Collaborating Centre in Australia (2008−2009).

He was a Chairman of the Academic Committee of Korean Liver Cancer Study Group (2010−2011) and the Asia Pacific Primary Liver Cancer Expert Meeting (APPLE 2013). He currently is a Chairman of the Publicity Committee of Korean Association of the Study of the Liver (KASL) (2014−2015). He is an advisor for the Ministry of Health and Welfare and the Ministry of Food and Drug Safety in Korea and a global advisory board member/speaker of many international pharmaceutical companies.

His major research interests include chronic hepatitis B, C, cirrhosis and liver cancer. He has completed and is complementing over 50 outstanding clinical trials as a principal investigator. He has over 200 SCI publications (Gastroenterology, Hepatology, Gut, Journal of Hepatology, etc as the first author) including book chapters and review articles in peer-reviewed journals. His invited oversea lectures are over 120 times around the world.

Prof. Sang Hoon Ahn is an Editor of Journal of Gastroenterology and Hepatology, Academic Editor of PLoS ONE and Special Section Editor of Gut and Liver. He is also an editorial board of Journal of Hepatology, Liver International, World Journal of Gastroenterology, Hepatology International, World Journal of Hepatology, World Journal of Virology, Gastroenterology and Hepatology Research, American Journal of Cancer Science, American Journal of Cancer Review. He sits on reviewer for NEJM, Lancet, Gastroenterology, Gut, Hepatology, etc.


VLADIMIR CHULANOVM.D., Ph.D.

Head of Reference Centre for Viral HepatitisHead of Clinical Diagnostics and Research CentreCentral Research Institute of Epidemiology

Dr. Vladimir Chulanov received his M.D. degree from Sechenov Moscow Medical Academy in 1995. In 1997 he completed a residency at the Infectious Diseases Department and received Ph.D. degree in 2003. From 2001, Dr. Chulanov worked in the Central Research Institute of Epidemiology as a scientific researcher and then as Deputy Head of the Center for Molecular Diagnostics. In 2007, he was appointed Head of the Clinical Diagnostics and Research Center, a position he still holds. In 2008, Dr. Chulanov became Head of the Reference Center for Viral Hepatitis, where he oversees an extensive research portfolio.

Areas of Specialty− Epidemiology, Molecular Epidemiology, Diagnostics, Prevention and Management of Viral Hepatitis and other Infectious Diseases

Current Position and Affiliation− Current − Head of Reference Centre for Viral Hepatitis, Head of Clinical Diagnostics and Research Centre at the Central Research Institute of Epidemiology, Moscow, Russia

Education1995 – Graduated from Sechenov Moscow Medical Academy1995 – 1997 – Post-Graduate fellowship in Infectious Diseases at Sechenov Moscow Medical Academy2001 – 2002 − International Emerging Infectious Diseases Fellowship, CDC, Division of Viral Hepatitis, Atlanta, USA2003 – Received PhD from Sechenov Moscow Medical Academy

Membership− Member of the Expert Group for Viral Hepatitis under the Russian Ministry of Health− European Association for the Study of the Liver− American Association for the Study of Liver Diseases− International Society for Infectious Diseases− Russian Society for the Study of the Liver− Russian National Scientific Society for Infectious Diseases

Publications− Over 100 articles and abstracts in leading national and international journals. Author and coauthor of the national regulatory documents and education materials for specialists.


PAVEL O. BOGOMOLOV

POSITION TITLE: Deputy Chief of Clinical and Diagnostic Work of the State Budgetary Healthcare Institution of Moscow Area “Moscow’s regional research clinical institute n.a. M.F. Vladimirskiy” (MONIKI) ,61/2 Schepkin str., 129110 Moscow, Russia

POSITIONS AND EMPLOYMENT:2014 – p.d. − Deputy Chief of the Clinical and Diagnostic Work of the State Budgetary Healthcare Institution of Moscow Area “Moscow’s regional esearch clinical institute n.a. M.F. Vladimirskiy” 2012 − 2014 − Physician − Clinical Hospital of Tsentrosoyuz, 57, Gilyarovskiy str., Moscow Russia2010 – 2012 − Senior staff scientist of Laboratory of Clinical Pharmacology and Anti-dote test - Scientific and Practical Center of Sports Medicine, Zemlyanoy Val str., 53 Moscow Russia2005 – 2014 − Gastroenterologist − “7th Central Military Clinical Aviation Hospital Department of Defense of Russian Federation”, Department of gastroenterology with room of functional diagnostics in gastroenterology, 17 Prosek Poperechniy Moscow 107014 2004 – present date The head of Hepatology department, Moscow Regional Scientific and Research Clinical Institute n. a. Vladimirskiy M.F., 61/2 Shepkin str., Moscow Russia 1291102001 − 2004 − Senior staff scientist of Gastroenterology Department, Moscow Regional Scientific and Research Clinical Institute n. a. Vladimirskiy M.F., 61/2 Shepkin str., Moscow Russia 1291101999 − 2001 − Resident, Clinical residency in Central Research Institute of Gastroenterology, 86 Enthusiastov highway, Moscow 111123 1998 − 1999 − General Practitioner, City clinical hospital # 50, Department of internal diseases, 21 Vuchetich str., Moscow 125206

OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS:2006 − Russian Society of liver study2004 − Russian Gastroenterology Association member

RESEARCH EXPERIENCE: Primary Investigator in Phase III, HBV, 2002 − 2005 (3 studies); phase III,

HCV, 2004 − 2006; phase II, 2005 − 2006. Phase IV, HCV, 2004; phase II, Liver cirrhosis, 2006; phase II, HCV, 2009, 2010, Phase Ia/IIb, III, IV, HCV,2012 – p.d.


DAVID METREVELIMD PhD

Education:1984−1990: State Medical University, Tbilisi, Georgia.1990−1991: Post-diploma training in the field of Pediatrics. 1992 and 1996: Post-diploma Training in the field of infectious diseases. Post-diploma Training Institute for Physicians. Tbilisi, Georgia.2000: Training course for Hepatology and Gastroenterology. Hospital of University, Freiburg, Germany. 2013: Training course for Hepatology. Liver Unit at Hospital General Universitario Valle Hebron, Barcelona, Spain. In 1999 has been awarded PhD. degree (Medical sciences).

Publications: 31 scientific papers and articles.

Employment History: 1990−1993: Infectious Diseases, AIDS and Clinical Immunology Research Center.

Position: Physician-Infectionist; 1993-2012: Department of Plasmapheresis and Intensive therapy.

Position: Head of the department. From 2012: Medical Center “Mrcheveli”, Hepatology and GastroenterologyDepartment. Position: Head of the department.

The study enrolled: 1. “ML 25544 Prospective observational study on predictors of on-treatment

response and sustained virological response in cohort of HCV-infected patients treated with pegylated interferons in Georgia; Position: Principal Investigator; 2011 – 2014;

2. Study number: 013012cRPh. Phase: I «An open label, parallel design study to assess the pharmacokinetics of Narlaprevir 200 mg as a single oral dose and in combination with Ritonavir 100 mg in patients with hepatic impairment and healthy matched volunteers». Position: Scientific consultant; 2013 – 2014.

Membership in Professional Societies: Member of Georgian Society of

Infectionists from 1992; Member of Georgian Hepatology Association (GHA) from 2000; At present President of GHA. Member of EASL from 2006.


ALEXANDER V. NERSESOVMD, ScD, Professor of Medicine – National Research Institute of Cardiology

and Internal Medicine, Almaty, Kazakhstan

Professor Nersesov is currently Head of the Department and Chair of Gastroenterology, Hepatology and Endoscopy at the National Research Institute of Cardiology and Internal Medicine, Almaty, Kazakhstan. He studied medicine at the Kazakh State Medical University and completed residency in internal medicine. Then Dr Nersesov went on to specialize in gastroenterology and immunology receiving his academic degrees of Candidate in Medical Sciences (1992), Doctor in Medical Sciences (1999), and academic ranks of Associate Professor and Full Professor (2003). Throughout his career Professor Nersesov has held professional appointment from Research Fellow (1992), Senior Research Fellow (1995) in the sequel and Head (2000) of the Clinical Department at the Research Center of Nutrition, Almaty, Kazakhstan to more recently Professor of Internal Medicine at the Kazakh State Medical Academy, Astana, Kazakhstan (2001−2008). Between 2001 and 2008 Professor Nersesov combined his academic career with state service at the Ministry of Health of the Republic of Kazakhstan as the Director of Medical Care and Prevention and the Counsellor for the Minister. In 2009 he moved to Japan where he spent a further year as a Visiting Fellow in Hepatology at the National Health Organization Nagasaki Medical Center. On returning to Kazakhstan, Professor Nersesov started working for the National Research Institute of Cardiology and Internal Medicine as a Head of Department of Gastroenterology and Hepatology (since 2009) and Chair of Gastroenterology, Hepatology and Endoscopy (since 2012). Professor Nersesov has professional affiliations with several professional organizations including European Association for the Study of the Liver (EASL), American Association for the Study of Liver Diseases (AASLD), Asian Pacific Association for the Study of the Liver (APASL). Since 2007 he is been serving as the President of the Kazakh Association for the Study of the Liver (KASL). Professor Nersesov’s main clinical and research interests are in chronic viral hepatitis and liver cirrhosis complications. He is author and co-author approximately 110 publications in local and international journals, provides clinical supervision, serves as a principal investigator in clinical trials and the main organizer of local and international conferences on gastroenterology and hepatology in Kazakhstan.


IULIANNA LUPASCOHead of Scientific Laboratory of Gastroenterology, MD, associate professor in

gastroenterology, hepatology. Chisinau. Republic of Molodva.

Profile: Administrative professional support offering versatile management skills and proficiency in creating, planning and fulfillment of scientific projects in gastroenterology and hepatology field, assessment of risk factors of chronic diffuse liver diseases development and progression, improvement of diagnostic and therapy protocols of CDLD and GT, clinical-practical implementation of patents and innovations. Strong planner and problem solver who readily adapts to change, works with team and exceeds expectations. Able to juggle multiple priorities and meet tight deadlines without compromising quality.

Education: State Univeristy Of Medicine And Pharmacy “N.Testemitanu”, Chisinau, Republic Of Molodva, Diploma with distinction ИВ №961467, June 26 1987Professional Development: PhD thesis in medical sciences 14.00.05 Internal Diseases «Interrelation of exocrine end endocrine function of the pancreas and chronic hepatitis» DH Diploma 14.93.32, November 29, 20001987−2009: working in Central Republic Hospital (physician, gastroenterologist)1998−2006 (SUMP “N.Testemitanu” part time: junior researcher, superior scientific researcher)2006 (SUMP “N.Testemitanu” part time: associate professor)Certificate awarding higher category as gastroenterologist, no.95 / p.4 untill20072009−2012: superior scientific researcher, Laboratory of GastroenterologyCertificate awarding higher category as gastroenterologist, no.95 / p.4 untill2012Certificate awarding higher category as gastroenterologist no. 1336 untill20172012 − present: Head of Laboratory of Gastroenterology

Experience Projects participation: From 2001 till present participated in 8 different International, National, institutional, fundamental, applicative projects on the hepatology field as an executive researcher

• 2015-prezent. “Chronic diffuse liver diseases – extrahepatic manifestations” Institutional, National, Applicative. Executive Senior Researcher

Patents: Holder of 7 patents; More than 20 innovations


Membership: Society of Gastroenterologists, Romania from 1994• Romanian Association for the Study of Liver from 1995• Association of Russian Gastroenterology from 1995;• Association of Hepatology and Gastroenterology “HEPATEG” RM from 2000• Corresponding Member of the International Academy of Ecology and Protection of Life in Russia (IALPS) from 2006• European Association for the Study of the Liver (EASL) from 2009,• Society of Internal Medicine, RM from 2009• Member of the International Society of Homotoxicology and Homeopathy (ISOHH)2012-2015 (winded up recently),• Member of the Association of people affected by liver and gastrointestinal diseases “HEPAVIT” − from 2013, holding the post of President of the Scientific Committee,

Awards: Awarded with the Medal of Hippocrates by the International Academy of Ecology and Life Protection in Russia (IALPS) 16.02.2006Congresses participation: During the last 5 years participated in over 20 congresses, conferences and scientific seminars in gastroenterology and hepatology on the national and international levels.Publications Over 200 publications.


IGOR A.KARPOV

1974−1980 – State Medical Institute in Minsk, Medical Faculty;1980−1981 – Intern− graduate course at the Clinical Hospital № 4 (therapy);1982−1985 – Resident of the department of Infectious Diseases at Minsk Medical Institute;2004 – Membership ESCMID2005 – Membership ISC2006 – Membership SIDA 2009 – Member of European Medical Academy of HIV2010 – Member of Infectious Diseases Society of America 2000 – Doctor of Medicine;2001 – Main Specialist of Ministry for Infectious Diseases 2003 – Professor

SCIENTIFIC INTERESTS:The problem of HIV− infection and AIDS, Viral hepatitis. Bacterial Sepsis andMeningitis.Author of 350 scientific works.

LARISA V. MOROZMD, Professor

Moroz Larisa Vasilivna, MD, Professor, Head of the Infectious Diseases Department of the National Pirogov Memorial Medical University, Vinnitsa, Ukraine. Head of the Hepatological Centre of the Vinnitsa city municipal hospital #1. Author of more than 250 scientific publications, scientific adviser of eleven PhD thesis’s, and two doctoral thesis. The main scientific activities are chronic viral hepatitis and HIV infection.


LOCALSPEAKERS


GAYANE MELIK-ANDREASYANMD, PhD, ScD, Professor CURRENT POSITIONDirector, The Research Institute of Epidemiology, Virology and Medical

Parasitology after A.B.Alexanian MOH RA, Yerevan, Armenia

Gayane G.Melik-Andreasyan graduated from General Medicine faculty the Yerevan State Medical Institute in 1977 with diploma of Honor. In 1977−1980 studied the post-graduate fellowship programme in the field of Virology at the Ivanovsky Institute of Virology, Moscow, Russia. In 1981 she got a PhD degree at Ivanovsky Institute of Virology, Moscow, Russia and in 2004 − Doctor of Medical Sciences (ScD) degree. She studied the intership progamme in laboratory diagnostics at the Pasteur Institute, Paris, France and in laboratory center Foundation Merieux, Lyon, France.

Since 1980 Gayane Melik-Andreasyan has worked in the Research Institute of Epidemiology, Virology and Medical Parasitology after A.B.Alexanian MOH RA, in 2007 was elected as a Director of Institute.

Current research interests of professor Melik-Andreasyan are: Epidemiology of Infectious Diseases, Laboratory diagnosis of Viral and Bacterial Infection, Investigation of Humoral Immunity against Infectious Diseases and Vaccination, biological quality of infectious agents, Prevention and Management of Viral Hepatitis and other Infectious Diseases.

Professor Melik-Andreasyan skillfully combines the research and teaching activities. She provides teaching cours on epidemiology and virology for students, residents of all medical specialties and traning course on TADR Epidemiology (DETRA Program). She has supervised numerous PhD thesises.She is an author of more than 210 scientific articles, abstracts and the national regulatory documents and educational material for specialists.

Gayane Melik-Andreasyan is a member of editional board of journal «In world of Viral Hepatitis» (Moskow, Russia), Asian Pacific Association for the Study of the Liver (APASL), Armenian Hepatological forum, Armenian.


GAYANE SAHAKYANM.D.

National Immunization Program Manager of Republic of Armenia since September, 2006. Since January, 2014 Advisor to the Director General of the National Center of Disease Control and Prevention of Ministry of Health of Armenia. Member of Governing Consul of the International Association of Immunization Managers since 2013, member of IRC (Independent Review Committee) of GAVI since 2014.

Has participated in various International meetings and forums for immunizations and immunization advocacy. Regularly has conducted workshops on immunization practices, VPD Surveillance and vaccine safety for Health Care workers.


HASMIK GHAZINYANMD, PhD

HEAD OF HEPATOLOGY DEPARTMENT OF “NORK” CLINICAL HOSPITAL OF INFECTIOUS DISEASES

Ghazinyan Hasmik L. is one of the Armenian leader experts in the field ofHepatology.

She is actively participating in National Research Studies aimed at investigations and improvement of liver health in Armenia.

Ghazinyan Hasmik L. graduated from Yerevan State Medical Institute in 1978 with Diploma of Honor and continued her fellowship program as a hepatologist locally and abroad, including USA in 1996.

Ghazinyan Hasmik L. is an author of more than 160 scientific publications in local and international journals.

Dr.Ghazinyan attended more than 220 specialized medical conferences (local and international) and was invited speaker and moderator in many of them.

Dr.Ghazinyan is: • Member of AARC working group, APASL ACLF. Research Consortium New Delhi, India• Member of EASL, APASL, IASL, CEVHAP.

She was: • Chairman of 1st International Hepatological Conference in Armenia in 2011 • o-chairman of 2nd Biannual International Conference of Armenian Hepatological Forum in 2013 • Co-chairman of 1st Transcaucasian Congress in Georgia in 2014.

Dr.Ghazinyan H.is:• President of Armenian Hepatological Forum.• Head of Department of Infectious Diseases and Epidemiology in Medical University named after ST.Tereza.• Member of Editorial Advisory council of scientific-practical journal Blood Armenia• Member of Editorial Advisory council of scientific practical journal Actual Infectology, Ukraine.• Author of Methodical Recommendations: Management of HBV and HCV Infections in Onco/Oncoheamatological Patients in the Republic of ArmeniaDr.Ghazinyan is a chairman of STC of APASL on HBV in Yerevan, Armenia,

in October 2015.


TIGRAN DAVTYAN

Education (degrees, dates, universities)2003 − Doctor of Biological Sciences (ScD). Field: Molecular Biology1993 − Candidate of Biological Sciences (Ph.D); Field: Genetics and Immunology 1989−1992 − Ph.D. student, Laboratory of Genetic Mechanisms of Cell Malignization And Differentiation, Institute of Cytology, St. Petersburg, Russia. 1983−1988 − Yerevan State Medical University, Faculty of Pharmacy

Career/Employment (employers, positions and dates)2011− up to present − Director of Analytical Laboratory of Scientific Centre of Drug and Medical Thechnology Experttise JSC 1999−2011 − Head of HIV-Clinical Trail Laboratory of the ARMENICUM Research Center, Yerevan, Rep. of Armenia.1998−2006 − Consultant on Science, Laboratory of Immunology, The Second Clinical Hospital of the Yerevan State Medical University, Rep. of Armenia.1998− up to present − Senior Research Scientist, Laboratory of Neurohormones Biochemistry, H. Buniatian Institute of Biochemistry, Natl. Acad. Sci. of Armenia.2002−2005 − Teaching Assistant in the Department of Diagnostics, National Institute of Health, Ministry of Health of the Republic of Armenia 1988−2003 − Senior Researcher, Laboratory of Immunology, Institute of Epidemiology, Ministry of Health of the Republic of Armenia 1989−1992 − Research Scientist, Laboratory of Genetic Mechanisms of Cell Malignization and Differentiation, Institute of Cytology, St. Petersburg, Russia. 1988−1989 − Senior technician in the Laboratory of Molecular and Cellular Immunology, Institute of Molecular Biology, Natl. Acad. Sci. of the Rep. of Armenia.


VIOLETA SARGSYANMD, PhD

HEAD OF CLINICAL SERVICESCLINICAL CENTRE «ARMENICUM“

Violeta Sargsyan is one of the leading experts in the field of hepatology and infectious pathology. She skillfully combines the clinical practice with scientific and research work, especially in the sphere of Hepatology and HIV infection.

Violeta Sargsyan is actively engaged in the study and development of new drugs. From the first day of Clinical Center «Armenicum» establishment she was a researcher in many clinical trials, later served as adviser (monitor) in different countries worldwide.

From 2002 to 2005 being as a monitor, she led the independent clinical research on the «Efficacy, Safety and Tolerability of the medicine «Armenicum» among HIV-infected patients» at Clinical Hospital after Botkin N30 in St. Petersburg and AIDS Center in Moscow.

Dr. Sargsyan is actively participating in many annual international

conferences on diseases of the liver (EASL, APASL, AASLD) and monothematic conferences in different countries: Italy, Spain, Japan, Holland, Singapore and Thailand.

She is the author of more than 80 scientific publications and poster papers which are published in both national and international journals. Besides Dr. Sargsyan is the author of 3 methodological guidelines for physicians.

V. Sargsyan graduated from Yerevan State Medical University (YSMU) in 1988 with honor. Since 1993 Violeta has been working as a deputy chief doctor of medical infections at #1 Infectious Hospital, simultaneously teaching at YSMU as a professor of infectious diseases department.

In 2005 she defended her PhD thesis in St. Petersburg which was devoted to «The phospholipid spectrum and lipid peroxidation in acute hepatitis B and chronic hepatitis C». As a result she received the degree of candidate of medical sciences of the Russian Federation.

Currently Violeta Sargsyan works as the head of clinical services at Armenicum Clinical Center. Dr. Sargsyan is a member of APASL and Armenian Hepatological Forum and is actively participating in organizational matters of the forum.


NARINA SARGSYANTSMD, PhD

INFECTIOUS DISEASE SPECIALIST DEPARTMENT OF INFECTIOUS DISEASES,

ARMENICUM CLINICAL CENTER

Sargsyants Narina Constantin is one of the leading hepatologists in Armenia.She graduated from the YSMU in 1996 and continued her specialization

in Residency in field of Infectious Diseases. From 1999 up to 2010 she was teaching at Department of Infectious Diseases YSMU.

Several Observerships in Hepatology/Gastroenterology and Infectious Diseases Departments in leading European Hospitals: France (CHU de Bicêtre, Paris), Austria (AKH, Vienna; SALK, Salzburg), Spain (Hospital Universitario Virgen Macarena, Seville) and Italy (Università Cattolica, Rome).

Narina Sargisyants is an author of more than 118 scientific publications (40 in English) and 17 poster presentations in international conferences (EASL, APASL, IAS, ISHEAD, ISVHLD, IUSTI, DICID etc.). Topic of her PhD research was “Clinical, epidemiological peculiarities and results of treatment with Pegylated interferon-alpha 2a and Ribavirin of chronic viral hepatitis C in Armenia”.

Dr. Sargisyants is an active participant of multiple local and International conferences, seminars. She is a member of Armenian Hepatological Forum, APASL and ISID.

Narina Sargisyants is a member of Editorial Board of World Journal of Hepatology.


NOTES

Conference: Focus on the Hepatitis B Virus

Documents

Transcript of Conference: Focus on the Hepatitis B Virus