Comparison of Hyperpolarized He and 129Xe MR Imaging in ... · Ummul AFIA Shammi MS Talissa Altes...
Transcript of Comparison of Hyperpolarized He and 129Xe MR Imaging in ... · Ummul AFIA Shammi MS Talissa Altes...
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Comparison of Hyperpolarized 3He and 129XeMR Imaging in Cystic Fibrosis Patients
Ummul AFIA Shammi MS
Talissa Altes MD
William Hersman PhD
Iulian Russet PhD
John Mugler III PhD
Craig Meyer PhD
Jamie Mata MS
Kun Qing PhD
Robert Thomen PhD
University of Missouri Columbia
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Comparison of Hyperpolarized 3He and 129XeMR Imaging in Cystic Fibrosis Patients
▪ Usage of hyperpolarized 3He is not economicallyfeasible because of its unavailability and high price.
▪ We are now motivated to shift towards the use ofcheaper and naturally available 129Xe.
To compare hyperpolarized 3He and 129Xe in patients with cystic fibrosis lung disease by direct voxel-wise correlations and
ventilation defect percentages
Objective
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10 patients with CF
(aged 33 ± 8 years)
3He MRI
GREsteady state free
precession (True FISP)
129Xe MRI
129Xe images
GRE images
voxels with signals < 60% of the whole-lung HP gas signal mean → Defects
Defects in 129XeDefects in 3He Matched Defects
Methods
GREsteady state free
precession (True FISP)
Study Population
Image Registration and Segmentation
3He images
True FISP images
Registered to
Registered to
3He GRE 3He True FISP 129Xe GRE 129Xe True FISP
VDP calculation
Common3He only129Xe only
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3He VDP 27.5%
129Xe VDP 27.07%
Results
3He VDP 31.5%
129Xe VDP 39.5%
correlation ρ= 0.84P value = 0.0015
correlation ρ= 0.59P value = 3.54×10-10
Sub
ject
8Su
bje
ct 3
3He voxel signals
3He voxel signals
12
9X
e v
oxe
l sig
nal
s1
29X
e v
oxe
l sig
nal
s
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Results
50
.8%
43
.9%
52
.1%
56
.3%
49
.5%
61
.1%
68
.2%
62
.1%
62
.1%
49
.8%
62
.7%
65
.7%
65
.4%
67
.8%
68
.1%
70
.1%
32
.5%
35
% 27
.3%
30
%
27
.3% 22
.6%
28
.6%
24
%
21
%
17
.1%
23
%
25
% 22
.4%
17
.7%
19
.1%
18
.6%
7%6.8% 4.6%6.3%
4.2%6.9%
5%5.7% 8.3%
5.3%8.1%8.5%
4.3% 7.4%7.8% 5.7%
8.7% 10.7%14.6%12.2%
7%
14.1%15.8%14% 4.4%7.8% 7.5%12%6.1% 4.8%4.9%4.6% 6.7%
GRE TF GRE TF GRE TF GRE GRE GRE TF GRE GRE TF GRE TF GRE
NormalCommon 3He only
129Xe only
Subj 1 Subj 2 Subj 3 Subj 4 Subj 5 Subj 6 Subj 7 Subj 8 Subj 9 Subj 1044yrs M 31yrs M 30yrs F 23yrs M 33yrs M 28yrs M 50yrs F 26yrs M 36yrs M 32yrs F
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m = 1.74m = 1.27m = 0.94
GRE
True FISP
Overall Fitted lineFitted for GREFitted for True FISP
➢On average, VDP was higher in 129Xe scans (33.8% ± 8.3% for 129Xe vs 30.91% ± 5.47% for3He), likely due to the much lower diffusion coefficient of Xenon vs Helium.
➢Although the VDP is higher for 129Xe, the scatter plot (above) shows the similarity betweenthe two gas distributions in all subjects (overall R2 = 0.70, slope= 1.27).
Conclusion
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Thank you