Company Aids Drug Kids Formulation? We Need HIV/AIDS IS TREATABLE

but millions of children are still waiting

HELP OUTSend a postcard to one of the

drug companies listed and joinMédecins Sans Frontières in

our push for the development ofquality AIDS drugs for children

The following companies produce some versions of AIDS drugs for children:

ritonavirlopinavir/ritonavir

didanosine lamivudine nevirapinestavudine zidovudinelamivudine/stavudine

Of 14 ARVs only 6 in kids form:didanosine efavirenz lamivudinenevirapine stavudine zidovudine

nevirapine

stavudine atazanavir didanosine

Of 20 ARVs only 7 in kids form:abacavir didanosine lamivudinenevirapine stavudine zidovudinelamivudine/stavudine/nevirapine

abacavir lamivudine zidovudineabacavir/lamivudinezidovudine/lamivudine zidovudine/lamivudine/abacavir

efavirenz

Of 13 ARVs only one in kids form:lamivudine/stavudine/nevirapine

enfuvirtide saquinavir nelfinavir

Yes, BUT syrupYes, BUT syrup

Yes – low dose tabletsYes, BUT syrupYes, BUT syrupYes – low dose capsulesYes – syrup and low dose capsNO

Yes, BUT syrupYes – syrup and low dose capsYes, BUT syrupYes, BUT syrupYes, BUT syrupYes, BUT syrup

Yes, BUT syrup

Yes – syrup and low dose capsNOYes – syrup and low dose tablets

Yes, BUT syrupYes – low dose tabletsYes, BUT syrupYes, BUT syrupYes – syrup and low dose capsYes – syrup and low dose capsYes – low dose tablets

Yes, BUT syrupYes, BUT syrupYes, BUT syrupNONONO

Yes – syrup and low dose caps

Yes – low dose tablets

NONOYes – powder and tablets

We need Abbott to make easy-to-useAIDS drugs for kids.

We need Aspen to make easy-to-usedoses of their four other AIDS drugs.

We need Aurobindo to make easy-to-usedrugs for kids.

We need BI to make this drug in easy-to-use pills for kids.

We need BMS to make easy-to-use kidsdoses for all drugs.

We need Cipla to speed up the pre-qualification by WHO of their three-in-one pill combination for kids, and tomake easy-to-use pills also for otherdrugs.

We need GSK to speed up thedevelopment of low-dosage tablets, andto study all of their new AIDS drugs inkids.

We need Merck to make its drugs forkids more available. We urge them tostudy efavirenz in kids under three.

We need Ranbaxy to speed up the pre-qualification by WHO of its three-in-onecombination for kids.

We need Roche to study nelfinavir inkids under three years and start makingits other drugs for kids.

Abbott 100 Abbott Park Rd, Abbott Park, IL 60064 USAwww.abbott.com

Aspen P O Box 1593 Gallo Manor, 2052 South Africawww.aspenpharma.com

Aurobindo Maitrivihar, Ameerpet, Hyderabad 500 038 INDIAwww.aurobindo.com

Boehringer Ingelheim Binger Str. 173 55216 Ingelheim GERMANYwww.boehringer-ingelheim.com

Bristol-Myers Squibb 345 Park Avenue NY, NY 10154 USAwww.bms.com

CiplaMumbai Central Mumbai400 008 INDIAwww.cipla.com

GlaxoSmithKline Stockley Park West UxbridgeMiddlesex UB11 1BT UKwww.gsk.com

MerckOne Merck Drive, PO Box 100, WhitehouseStation NJ 08889 USA www.merck.co

Ranbaxy Gurgaon -122001 Haryana INDIAwww.ranbaxy.com

RocheGrenzacherstr.124 CH-4070, BaselSWITZERLAND www.roche.com

Across the globe last year, an estimated 540,000children under 15 were newly infected with HIV, ofwhom nearly 90% live in Africa. But there are noaffordable AIDS tests that work in babies, or medicinesthat children can take easily. And without treatment,half of all babies born with HIV in poor countries diebefore their second birthday. But because developingAIDS drugs for poor children is not profitable, manycompanies don’t even study the effects of existing ornew adult antiretroviral drugs in children. As anexample, WHO recommends efavirenz for treatingAIDS in children, but to date it still has not beenstudied in children under three years. At least twocompanies, Cipla and Ranbaxy, are developing much-needed triple-drug formulations for children. And somecompanies are working on low dosage tablets for kids.But we need to put pressure on all drug companies tosystematically study all of their AIDS drugs in childrenand make easy-to-use formulations for kids now. Wemust make sure that the youngest people living withAIDS are not forgotten.

THE PROBLEM WITH THE DRUGFORMULATIONS AVAILABLE NOW:Syrups can taste bitter, are hard to dose correctly, andoften need refrigeration, which frequently doesn’t existin poorer countries. Plus, syrups always cost morethan pills. Syrups are an unacceptable status quo.

Adult tablets need to be crushed so children can takethem, making it difficult to give the right dose – bothover-dosing and under-dosing can be dangerous.

WHAT WE NEED:Quality drugs in solid form are the solution, but they need to come in varying sizes, so that caregivers can easilygive children the doses they need as they grow. Syrups will still be needed for the youngest of babies, but theseshould not require refrigeration.

We need quality AIDS drugs for kids now...

This list shows what we need the major originator and generic drug companies

to do for kids with AIDS:*

Today, the following companies don’t produce any of their AIDS drugs for children:

Company Aids Drug Kids Formulation? We Need

Gilead 333 Lakeside Drive emtricitabine NO We need Gilead to speedFoster City, CA 94404 USA tenofovir disoproxil fumarate NO up studies of their AIDSwww.gilead.com tenofovir/emtricitabine NO drugs in kids.

HeteroH.no .8-3-166/7/1, Erragadda produces 17 ARVs NO We need Hetero to makeHyderabad, 500018 INDIA AIDS drugs for kids.www.heterodrugs.com

StridesBilekahalli Bannerghatta Road Produces 8 ARVs NO We need Strides to makeBangalore, 560076 INDIA AIDS drugs for kids.www.stridesarco.com

*This is not an exhaustive list of needed and available drugs. The information in this table is based on information provided by companies for the MSFprice report “Untangling the web.” see: www.accessmed-msf.org