COLUMBIA UNIVERSITY MEDICAL - The United Mitochondrial ......Mitochondrial Replacement Study (COMRS)...
Transcript of COLUMBIA UNIVERSITY MEDICAL - The United Mitochondrial ......Mitochondrial Replacement Study (COMRS)...
Microscopicimageshowinganucleargenomebeingremovedfromadonoregg(oocyte).
Whoiseligible?
WomenwhocarryknownharmfulmtDNAmutationsages18-37years-old.
Whatisthecost?
Study-relatedprocedureswillbecoveredbytheproject.Travel-relatedexpensesmaybecovered.
ContactInformation
AboutUs
ColumbiaUniversityMedicalCenterhasinternationallyrenownedexpertsinmitochondrialdisease,stemcellbiology,andIVFwhoarecollaboratinginthisimportantresearchprojecttoassesssafetyandfeasibilityofOMR.InvestigatorsincludeDr.RogerioLobo,MD,Dr.DieterEgli,PhD,andDr.MichioHirano,MD.
ContactUs
Dr.MichioHiranoorMs.KristinEngelstadMSCGC
Phone:1-212-305-6834Email:[email protected]
TheColumbiaOocyteMitochondrialReplacementStudy(COMRS)
InvestigatingOocyteMitochondrialReplacement(OMR)topreventtransmissionofmitochondrialDNAmutations
COLUMBIAUNIVERSITYMEDICALCENTER
IRB-AAAM3550
for use until: 02/14/2018IRB Approval Date: 02/15/2017
Whataremitochondriaandmitochondrialdiseases?Oftendescribedasthepowerhousesofcells,mitochondriaareessentialcellularcomponentsthatproduceenergy.Virtuallyeverycellinourbodiescontainmitochondria,whichhavetheirownDNA:mitochondrialDNA(mtDNA),whichisuniqueandseparatefromnuclearDNA(nDNA).MutationsineithermtDNAornDNAcandisruptmitochondrialfunctionsleadingtodiversediseasesthatoftenaffectmultipleorgans.
UnderstandingmtDNAmutationsBecausemtDNAsarepresentinhundredsorthousandsofcopiespercell,theproportion(heteroplasmy)ofmutantmtDNAcanvarywidelyandcandictatetheseverityofapatient’smitochondrialdisease.AnotherspecialpropertyofmtDNAisitsmaternalinheritance;onlymotherspassontheirmtDNAtotheirchildren.
Oocytes(eggsshownascircles)containingamixedpopulationofmutant(red)andnormal(green)mitochondriatransmitmtDNAafterfertilizationtodaughtercells.
Oocytemitochondrialreplacement
OurgoalToinvestigatethesafetyandeffectivenessofOocyteMitochondrialReplacement(OMR)asmeanstopreventtransmissionofmtDNAtooffspring.
Whatisinvolved?WomenwhocarrymtDNAmutationscanparticipateinthisstudy.TheywillundergotheeggharvestingstagesofInVitroFertilization(IVF),awell-establishedtreatmentformanyformsofinfertility.Thenucleargenomeofanunaffecteddonor’soocytewillberemoved.ThenthenuclearDNAfromtheoocytewithamtDNAmutationwillbetransferredintotheenucleatedoocyteofthedonor.Thisstudywillresultinembryosthatarecryopreservedandwillnotresultinpregnancy.Embryotransferintotheuterus(womb)maybepartofafuturestudythatwillrequireapprovalbytheFoodandDrugAdministration(FDA).
IRB-AAAM3550
for use until: 02/14/2018IRB Approval Date: 02/15/2017