Colostrum Overview

(Reference File)

By- Chintan Chavda

chintan_rxz@yahoo.com

Colostrum Overview

1. What is colostrum?

Colostrum is the pre-milk liquid that mothers produce at birth. Commonly referred to as "baby's first

milk" and “biologic soup,” colostrum is the leftover mixture of materials present in the mammary

gland and ducts at delivery. It slowly becomes mixed with newly secreted milk, yet it differs from

mature milk in composition and is not as plentiful.

Breasts produce colostrum beginning during pregnancy and continuing through the early days of

breastfeeding. This special milk is yellow to orange in color and thick and sticky.

It is low in fat, and high in carbohydrates, protein, and antibodies to help keep your baby healthy.

Colostrum is extremely easy to digest, and is therefore the perfect first food for your baby. It is low

in volume (measurable in teaspoons rather than ounces), but high in concentrated nutrition for the

newborn. It is full of immune-enhancing antibodies, other important immune factors, and essential

growth factors to ensure health and vitality for adults and children.

Colostrum versus Whole milk (Ref- Feeding and Nutrition, Publ. by Cooperative Extension, Institute of Agricultural and Natural Resources, University of Nebraska-Lincoln, Issued May 1990)

Specification Colostrum

(1st milking) Whole milk

(11th milking)

Total solids (%) 23 13

Total Protein (%) 14 4

Casein (%) 4.8 2.5

Immunoglobulins (%) 6 0.09

Fat (%) 6.7 4

Lactose (%) 2.7 4.9

Minerals (%) 1 0.74

2. What makes Bovine colostrum so beneficial?

There are over 90 known components in colostrum. The primary components, divided into two

classes, are immune factors and growth factors. Colostrum also contains a precise balance of

vitamins, minerals and amino acids. All of these factors work together in perfect synergy to

restore and maintain health.

Colostrum's Immune Factors :

Immune Factors in colostrum have been shown to help the body fight off harmful invaders such

as viruses, bacteria, yeast and fungus. Each factor plays a specific role in our bodys defense

against these attackers. In addition, colostrum contains over 20 antibodies to specific pathogens

including E coli, salmonella, rotavirus, candida, streptococcus, staphylococcus, H pylori, and

cryptosporidia.

In addition to immunoglobulins, medical studies show that PRP in colostrum also supports an

under active immune system. PRP also helps balance an overactive immune system present in

autoimmune diseases.

Colostrums’ Growth Factors :

Growth Factors help build and restore bone, muscle, nerve tissue, connective tissue, skin and cartilage.

These factors have also been shown to help increase lean muscle, help the body burn fat for fuel, and

assist in wound healing. Growth factors have also been shown to help slow the signs of aging.

Colostrums’ growth factors may:

Affect the brain's mood regulating chemicals to brighten our moods. (Serotonin &

dopamine)

Assist in regeneration and improve normal growth of aged or injured muscle, bone,

cartilage, skin collagen and nerve tissue.

Help burn fat for fuel instead of muscle tissue in times of fasting (diet), and build & retain

lean muscle (non-diet).

Assist the internal regulation of blood glucose levels and "brain chemicals", supporting

alertness and better concentration.

Support healing skin when applied topically

Repair our body\'s precious RNA and DNA.

Other Beneficial Components :

Vitamins and Minerals are nutrients that are essential for normal metabolism, growth and

development. They act as coenzymes, enabling chemical process to take place

throughout the body. Vitamins and minerals are indispensable for the maintenance of

health.

Amino Acids are the building blocks of proteins. They are required for growth and

development. Amino acids are divided into essential (not produced by the body) and

nonessential (can be produced by the body).

Known Components of Bovine Colostrum

1. Immune Factors - Immunoglobulins: - Antibodies

IgG - Neutralizes toxins and other invaders; including viruses and bacteria

IgM - Destroys bacteria, controls antibody response

IgD - Antiviral, prevents hemolytic disease in infants

IgE - Involved in regulating allergic response

IgA - Highly antiviral and antibacterial, prevents infection

Secretory IgA (SigA) - Found in mucous membranes, helps protect against infection

IgA Specific Helper - Stimulates the production of IgA

Lactoferrin - Powerful antioxidant, antiviral, antibacterial, anti-inflammatory

Lactoferrin-Fe - Iron chelator

Transferrin - Binds and transports iron

Glycoproteins: - (Including Protease and Trypsin Inhibitors) Protect components from

destruction by stomach acids

Lactalbumin - Raises brain serotonin levels, improves mood under stress

Multimeric a-Lactalbumin - Shown to cause lung cancer cells to create selective suicide

(apoptopsis)

Cytokines - (Including Interleukins, Interferon Y, Tumor Necrosis Factor (TNF), and

Lymphokines) Antiviral, anti-tumor (stimulates death of some tumors), increase T-cell activity,

responsible for regulation and intensity of immune response, stimulate production of

immunoglobulins

Proline-Rich Polypeptide (PRP) - Regulates the activity of the immune system

Lysozymes - Help protect body from bacterial infection, topical antibiotic

Gamma Globulin - Resists infection

B Lactoglobulin - Antibody, protein

Complement 3 & 4 (C3 & C4) - Proteins that activate the complement of the immune system

Kappa Casein - Glycoprotein that protects against the bacteria that causes stomach ulcers

Alpha 2-AP glycoprotein

Alpha 1- antitrypsin - Inhibitor of trypsin

Alpha 2- macroglobulin - Function as hormonal transporters

Orosomucoids - Alpha-1 protein in plasma

Prealbumin - Precursor to albumin

Albumin - Contains essential amino acids

Oligosaccharides - Complex carbohydrates, help prevent lung inflammations and ear infection

Non Specific Inhibitors (NSI\'s) - Factors that inhibit a wide range of respiratory illness

2. Growth Factors

Epithelial Growth Factor (EGF) - Helps protect and maintain the skin

Fibroblast Growth Factor (FGF) - Enhances wound healing and tissue repair

Insulin-like Growth Factor I (IGF-I) - Increases lean muscle mass, helps repair DNA and RNA,

anti-aging, may regulate blood-sugar and cholesterol levels

Insulin-like Growth Factor II (IGF-II) - Affects how the body uses fat and protein

Growth Hormone (GH) - Regulates growth, decreases signs of aging

Transforming Growth Factor - a (TGF- a) - Assists in formation and healing of connective tissue,

bone and cartilage

Transforming Growth Factor - b (TGF - b) - Helps repair tissue, supports growth of the lining of

the gut. Shown to produce cell destruction in certain human cancers.

Platelet-Derived Growth Factor (PDGF) - Stimulates growth of connective tissue, plays a role in

wound healing and helps with cell division and neuron survival and regeneration

Gonadotropin-Releasing Hormone (GnRH) - Stimulates release of follicle-stimulating hormone,

gonadotropic substances and treats endometriosis

Prolactin - Similar to Growth Hormone

Insulin - Responsible for proper metabolism of blood sugar

Sulfur - An important building block of proteins

3. Vitamins and Other Nutrients

Vitamin B6 - Produces serotonin, utilization of amino acids

Vitamin B12 - Normal development of red blood cells

Vitamin E - Antioxidant, supports wound healing and immune function

Vitamin A (from carotene) - Resistance to infections, maintains cell integrity

Vitamin C - Antioxidant, immune system support

Thiamin (Vitamin B1) - Metabolism of carbohydrates, energy

Folic Acid - Cell replication and tissue growth

Pantothenic Acid - Metabolism of fats, carbohydrates and protein

Riboflavin (Vitamin B2) - Energy production, tissue repair, healthy eyes

Beta-carotene - Antioxidant

Glycoconjugates - Carbohydrates that link to lipids and proteins

Glycogen - Converts into glucose when needed by tissues

Retinoic Acid - Metabolite of Vitamin A, used in treatment of acne

4. Minerals

Calcium - Maintains strong, healthy bones, activates enzymes

Chromium - Glucose metabolism disorders, body fat reduction

Iron - Oxygen transport and storage, energy, immune support

Magnesium - Muscle relaxation, assists with psychiatric disorders

Phosphorus - Strengthens bones and teeth

Potassium - Lowers blood pressure, maintains fluid balance in cells

Sodium - Cell membrane integrity, plays important role in nerve function

Zinc - Synthesis of DNA and RNA, activates Vitamin A

5. Essential Amino Acids

Isoleucine - Assists in muscle development & repair, helps regulate blood sugar

Leucine - Involved in muscle repair, wound healing and hormone production

Histidine - Involved in growth and tissue repair

Methionine - Antioxidant, collagen synthesis, helps prevent arterial fat buildup

Lysine - Aids in calcium absorption, helps regulate antibody and enzyme production

Threonine - Stimulates antibody production

Phenylalanine - Assists neurotransmitter function, increases \"feel good\" chemicals in brain

Valine - Regulates energy, aids growth and repair of muscle tissue

Tryptophan - Stimulates niacin production, precursor for serotonin

6. Nonessential Amino Acids

Arginine - Stimulates GH, immune function, promotes wound healing and muscle growth

Cystine - An antioxidant involved in collagen synthesis

Glutanic Acid - Helps transport potassium to the brain, implicated in neurological conditions

Alanine - Involved in glucose metabolism

Tyrosine - Regulate mood, may improve memory, appetite suppressant

Glycine - Helps decrease muscle wasting, aids in glycogen storage

Proline - Aids in wound healing and collagen synthesis

Aspartic Acid - Helps synthesis of DNA, RNA, Ig and antibodies, involved in energy metabolism

Serine - Involved in fat metabolism and muscle growth, noted moisturizer

7. Additional Factors Found in Colostrum

Beta 2- microglobulin - Components of many cell membranes including leukocytes

Enzymes - Induce chemical changes in the body

Haemopexin - Iron-binding protein

Haptoglobulin - Glycoproteins that aid the recycling of iron

Lactoperoxidase - An antioxidant

Orotic Acid - Precursor to certain nucleotides

Peroxidase - Transfers oxygen to tissues, helps prevent free radical damage

Xanthine Oxidase Enzyme - Enzyme involved in conversion of hypoxanthine to xanthine

Lactobacillus Acidophilus, Bifidobacterium, Lactobacillus Bifidus - Help restore a supportive

bacterial environment in the body.

3. How Does Colostrum Work?

Colostrum is highly beneficial in the unique manner in which it provides the body with its

numerous immune and growth factors. Most infectious disease-causing organisms enter the

body through the mucous membranes of the intestinal tract. In order to remain healthy, it is

critical that we are able to combat disease-causing organisms, such as bacteria and viruses, as

well as environmental toxins, contaminants and allergens where they attack us.

Clinical research by Dr. David Tyrell in England, published in 1981, revealed that a high

percentage of the antibodies and immunoglobulins present in colostrum are believed not to be

absorbed but remain in the intestinal tract where they attack disease causing organisms before

they can penetrate the body and cause disease. The remainder are absorbed and distributed to

assist in our internal defense processes. It is this combination of action that makes colostrum as

unique and effective as an oral supplement.

4. Bovine Colostrum for New Born

When baby is breastfed early and often, breasts will begin producing mature milk around the

third or fourth day after birth. Milk will then increase in volume and will generally begin to appear

thinner and whiter (more opaque) in color. In those first few days it is extremely important to

breastfeed newborn at least 8-12 times each 24 hours and more often is even better. This

allows baby to get all the benefits of the colostrum and also stimulates production of a plentiful

supply of mature milk. Frequent breastfeeding also helps prevent engorgement.

Colostrum provides not only perfect nutrition tailored to the needs of the newborn, but also large

amounts of living cells which will defend the baby against many harmful agents. The

concentration of immune factors is much higher in colostrum than in mature milk.

Colostrum actually works as a natural and 100% safe vaccine. It contains large quantities of an

antibody called secretory immunoglobulin A (IgA) which is a new substance to the newborn.

Before the baby was born, Baby received the benefits of another antibody, called IgG, through

your placenta. IgG worked through the baby's circulatory system, but IgA protects the baby in

the places most likely to come under attack from germs, namely the mucous membranes in the

throat, lungs, and intestines.

Colostrum has an especially important role to play in the baby's gastrointestinal tract. A

newborn's intestines are very permeable. Colostrum seals the holes by "painting" the

gastrointestinal tract with a barrier which mostly prevents foreign substances from penetrating

and possibly sensitizing a baby to foods the mother has eaten.

Colostrum also contains high concentrations of leukocytes, protective white cells which can

destroy disease-causing bacteria and viruses.

The colostrum gradually changes to mature milk during the first two weeks after birth. During

this transition, the concentrations of the antibodies in milk decrease, but milk volume greatly

increases. The disease-fighting properties of human milk do not disappear with the colostrum. In

fact, as long as your baby receives milk, Baby will receive immunological protection against

many different viruses and bacteria.

5. Is Bovine Colostrum Safe and Effective in Human?

Research has shown that bovine colostrum is easily assimilate by humans and is up to 40 times

richer in immune factors than human colostrum. Also, the research shows that only cows’

colostrum contains special glycoproteins and protease inhibitors which are extremely effective

at protecting the destruction of colostrum’s active components by adult human digestive

enzymes and stomach acids.

And bovine colostrum is safe for consumption by humans. According to Dr. Robert Preston with

the International Institute of Nutritional Research, “Colostrum is so safe; it has been prepared by

nature as the first food for infants. It would be hard to imagine any nutritional substance more

natural or beneficial.”

There have been no contra-indications, side effects or allergies reported through thousands of

years of human use of bovine colostrum. And this superfood creates no problems for those with

lactose intolerance.

Yes, only colostrum from dairy cows has been shown to be safe, natural, effective and

biologically transferable for human use.

Bovine colostrum is not a drug: It is a safe, natural, non-allergenic food, taken by humans to

treat and heal dozens of conditions- plus help create new levels of vitality and well being.

To insure a pure, unadulterated product (colostrum) cows should be pasture-fed on grass that

has not been treated with pesticide, herbicide, or fungicide. They should not be subjected to

courses of antibiotics, steroids, and growth hormones as are most other dairy cows. These

substances contaminate the colostrum and milk of cows, in addition to posing potential health

risks to those who ingest the milk or colostrum, render the colostrum less effective.

When cows feed on naturally raised pasture, they are exposed to a great variety of naturally

occurring disease causing organisms, which allows them to develop natural immunity, which is

then passed on in their colostrum.

Bovine colostrum contains substances that are effective against many of the different

microorganisms that are now resistant to the antibiotics on the market

Bovine colostrum is not species specific. That means it can be consumed safely by every

mammal, including humans. In particular, the molecular structure of the immune and growth

factors in bovine colostrum is very similar to those found in humans. In a sense, cows are

universal donors of colostrum.

6. Does bovine colostrum have any side effects?

Colostrum is a high-protein, low fat and reduced lactose dairy product, as a result lactose-

intolerant individuals generally experience no problems and some even report that colostrum

helps with their condition. If you can drink milk without any problem then you can probably take

colostrum. Some individuals may experience a mild gastrointestinal distress or a bloated feeling,

which can be avoided by lowering the dose. If this reaction continues however then it is best to

discontinue the colostrum treatment. However, as with all health supplements, it is always

advisable to consult with your doctor in the first instance. Colostrum used naturally contains low

levels of lactose and during processing these are reduced further

7. Health benefits/Application of Bovine colostrum

a. Bovine Colostrum Studies on Athletic Performance

The Journal of Sports Medicine, September, 2006, reports that bovine colostrums helped male

distance cyclists retain more energy following a bout of intensive training. These cyclists who

used bovine colostrums performed at a higher level with fewer signs of fatigue during tests

taken after their five days of intensive training.

The European Journal of Nutrition, August, 2003, reports an investigation of whether

concentrated bovine colostrum affected the incidence or duration of self-reported symptoms of

upper respiratory tract infections in adult males. Based on self-reports in a double blind, placebo

controlled study, preliminary evidence was found that concentrated bovine colostrum protein

may enhance resistance to the development of symptoms of upper respiratory tract infection.

The Journal of Sports Science, July, 2003 reports a study examining the effects of bovine

colostrum on peak vertical jump power, peak cycle power, alactic anaerobic work capacity,

resistance exercise one-repetition maxima, and plasma insulin-like growth factor (IGF-1)

concentrations.

This randomized, double-blind, placebo, controlled, parallel design study concluded that bovine

colostrum supplementation during training significantly increased peak anaerobic power, but

had no effect on alactic anaerobic work capacity.

b. Bovine Colostrums and Distal Colitis

The Ailmentary Pharmacology and Therapeutics, November, 2002, reports a study designed to

examine the efficacy of colostrum enemas in the treatment of distal colitis during a randomized,

double-blind, controlled protocol. Fourteen patients with a mean age of 45 and mild to

moderately severe distal colitis were given colostrum enema or placebo for 4 weeks. Both

groups also received mesalazine initially or as an increased dosage. After the 4 weeks, the

colostrum group showed a mean reduction in symptoms of -2.9, while the placebo group

showed a mean response of +0.5. Researchers concluded that bovine colostrums enema

shows potential as a novel therapy for left-side d colitis with an additional benefits over using me

sala zine alone.

c. Bovine Colostrums and Drug-Induced Intestinal Permeability

The June, 2001 edition of Clinical Science reports that the use of non-steroidal anti-

inflammatory drugs (NSAIDs) cause gastrointestinal injury. Bovine colostrum is a cheap, readily

available source of growth factors, which reduces gastrointestinal injury in rats and mice.

Researchers hypothesized that colostrum could reduce the rise in gut permeability caused by

NSAIDs in volunteers and patients taking NSAIDs for clinical reasons. Two studies were

performed, the first on the healthy volunteers, and the second on the NSAIDs patients. In the

first group, no increased gut permeability was seen when colostrum was co-administered with

NSAID indomethacin. Indomethacin alone caused a 3-fold increase in gut permeability. In the

second group, permeability was not influenced by co-administration of test solutions.

Researchers concluded that bovine colostrum may provide a novel approach to the prevention

of NSAID induced gastrointestinal damage in humans.

Bovine colostrum is rich sources of various growth factors. While the concentration of the

growth factors present has been incompletely defined, IGF I and II, TGF-β, and epidermal

growth factor (EGF) have been identified in Bovine colostrum. Since these growth factors are

capable of stimulating growth and repair processes within the gastrointestinal tract (GI), two

studies have been conducted to determine what effect, if any, dietary supplementation might

have on non-steroidal anti-inflammatory drug (NSAID)-induced GI inflammation and

permeability. Bovine colostrum utilized in the two trials contained approximately 43 g/L protein

content (primarily consisting of Ig) and the following growth factor profile (values are

approximations): IGF-I and II 2 mg/L, TGF-β 25 µg/L, and EGF 6 µg/L. The preliminary results

obtained suggest benefits for persons acutely exposed to NSAIDs; however, BC did not appear

to provide any GI benefits among persons chronically utilizing NSAIDs.

In an initial study conducted in rats, supplementation with Bovine colostrum resulted in a dose-

dependent reduction in the amount of GI damage caused by indomethacin. A milk solution used

as a placebo was not effective. As a result of the positive outcome, a study on the effects of

Bovine colostrum on NSAID-induced intestinal permeability in humans was conducted. A milk

whey solution with similar protein content but lacking growth factors was used as a placebo.

Prior to commencing the studies, the Bovine colostrum preparation was tested against the

placebo to determine whether either an effect on intestinal permeability had. The five days of

supplementation did not have an effect on baseline intestinal permeability values in persons not

taking NSAIDs.

In the first study, seven males, following an initial baseline permeability assessment,

supplemented their diets with 125 mL Bovine colostrum or whey placebo three times daily for

seven days. Indomethacin was introduced on days 3-7. After completing this arm of the trial, a

two-week washout period was followed by a second arm of the trial in which participants

receiving the active intervention were switched to the placebo, while those receiving the placebo

received active treatment. Permeability increased approximately threefold in response to

indomethacin in the participants taking the whey placebo while no significant increase in

intestinal permeability was observed when the Bovine colostrum preparation was co-

administered with indomethacin.

In the second study, 15 persons taking NSAIDs (ibuprofen, piroxicam, voltarol, or naproxen) for

at least one year were randomized to receive either 125 mL Bovine colostrum or placebo three

times daily for seven days with a two-week washout period between study arms. Baseline

permeability assessments were lower in these persons than in volunteers in the previous trial

(who were not taking NSAIDs chronically). No significant effect of either the active or placebo

treatment was observed.

Consistent with results of the first study, short-term treatment with NSAIDs has previously been

shown to increase intestinal permeability. However, conflicting reports on the impact of chronic

long-term use of NSAIDs on intestinal permeability exist. Struthers et al, consistent with

previous observations, have reported low intestinal permeability with long-term NSAID use,

while Sigthorsson et al reported an approximate two-fold increase. Currently no explanation

exists for these disparate observations. While short-term doses of NSAIDs appear to

consistently increase intestinal permeability, it is possible that long-term use of NSAIDs results

in an adaptation response by the small intestine, at least in certain individuals. Irrespective of

the explanation, BC appear to hold promise as a dietary addition in persons beginning NSAIDs,

but not for persons chronically taking NSAIDs while being free of adverse GI effects.

d. Bovine Colostrum and Gastrointestinal health

Review of irritable bowel syndrome, including ulcerative colitis and Crohn's disease, and its

etiology, including infective agents such as Shigella and Campylobacter. Infections of the gut are

difficult to treat because no antimicrobial therapy is available that is effective against Clostridia

spores. Only bovine colostrum has proven clinical efficacy in eradicating intestinal pathogens, such

as rotavirus, and may help control the infections seen in chronic disorders such as irritable bowel

syndrome due to the number of biologically active components in colostrum. The growth factors in

colostrum help heal intestinal erosions and ulcerations. It also contains anti-inflammatory factors

and is nutrient rich. Colostrum may be used alone or in combination with other anti-inflammatory

and/or immune substances.

Ref- Borody TJ, Surace R, Warren E. Tunnel vision in the bowel. Center for Digestive Diseases (2001)

Factors in colostrum which promote the development of the GI tract in newborn infants also help

protect against such diseases as Crohn’s disease, colitis, necrotizing enterocolitis and diarrhea.

Ref- Carver JD, Barness LA. Trophic factors for the gastrointestinal tract. Clinical Perinatology 23(2):265-285 (1996).

In an in vitro experimental study, colostrum stimulated intestinal cell growth and reestablished a

healthy epithelial layer following injury. In an in vivo experimental study, colostrum powder was

also shown to reduce gastric injury.

Ref- Gastrointestinal Inflammation and Repair Group, Imperial College, London (2003).

NSAIDs given to animals have much the same effect as they do in humans, namely, increased

intestinal permeability, increased enteric bacteria levels, villous loss, and loss of enteric protein and

albumin. Supplementation with bovine colostrum reduced the increase in intestinal permeability,

the enteric bacteria overgrowth, the loss of proteins, and villous damage.

Ref- Kim JW, Jeon WK, Yun JW, Park DI, Cho YK, Sung IK, Sohn CI, Kim BI, Yeom JS, Park HS, Kim EJ, Shin MS. Protective effects of bovine

colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pacific Journal of Clinical Nutrition 14(1):103-107 (2005).

Mammalian colostrum offers passive protection against a variety of microbial pathogens.

Preparations from immune milk and colostrum have proven effective in the prevention of various

gastroenteric infections without the risk of transferring disease from mother to infant.

Ref- Lilius EM, Marnila P. The role of colostral antibodies in prevention of microbial infections. Current Opinion in Infectious Diseases14(3):295-300

(2001).

The proteins found in colostrum can promote the growth of beneficial bacteria such as Lactobacilli

and Bifidobacteria in the gut.

Ref- Lonnerdal B. Nutritional and physiologic significance of human milk proteins. American Journal of Clinical Nutrition 77(6):1537S-1543S (2003).

Non-steroidal Anti-inflammatory Drugs are effective against arthritis but cause gastrointestinal

injury. Taking colostrum prior to NSAIDs reduced gastric injury by up to 60%.

Ref- Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA, Marchbank T. Bovine colostrum is a health food

supplement which prevents NSAID induced gut damage. Gut 44(5):653-658 (1999).

Colostrum or peptides derived from it are useful for the treatment of a wide variety of

gastrointestinal conditions, including inflammatory bowel disease, NSAID-induced gut injury, and

chemotherapy-induced mucositis.

Ref- Playford RJ, MacDonald CE, Johnson WS. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal

disorders. American Journal of Clinical Nutrition 72(1):5-14 (2000).

A bovine colostrum IgG concentrate specific against C. difficile resists digestion in the GI tract and

retains its toxin-A binding abiliity and neutralizing activity is retained.

Ref- Warny M, Fatimi A, Bostwick EF, Laine DC, Lebel F, LaMont JT, Pothoulakis C, Kelly CP. Bovine immunoglobulin concentrate-clostridium difficile

retains C difficile toxin neutralising activity after passage through the human stomach and small intestine. Gut 44(2):212-217 (1999).

Bovine colostrum has higher amounts of immunoglobulins, growth factors, cytokines and

nucleosides than mature milk. It is also rich in oligosaccharides, antimicrobials, and immune-

regulating factors. Research indicates that colostrum can have a beneficial effect on improving

body composition, athletic performance, diarrhea (particularly in people with immune deficiency),

gastrointestinal disturbances, and infectious diseases.

Ref- Kelly GS. Bovine colostrums: a review of clinical uses. Alternative Medical Review 8(4):378-394 (2003).

Polyamines, including spermidine, spermine and putrescine, are highly regulated polycations

involved in cell growth and differentiation. They play an important role in the maturation of the

newborn’s intestine. They are present in all mammalian milk and colostrum.

Ref- Löser C. Polyamines in human and animal milk. British Journal of Nutrition 84(Suppl 1):S55-8 (2000).

Nucleosides, nucleotides and nucleobases are all present in colostrum and milk. They act as

regulators in the body. Nucleotides affect immune responses in infants. Nucleotides and

nucleosides contribute to iron absorption in the gut and influence saturation and elongation rates in

fatty acid synthesis. Ribonucleosides modulate cell proliferation and apoptosis (cell death).

Ref- Schlimme E, Martin D, Meisel H. Nucleosides and nucleotides: natural bioactive substances in milk and colostrum. British Journal of

Nutrition 84(Suppl 1):S59-S68 (2000).

e. Bovine Colostrum and Respiratory Health

In dealing with something as elusive as the common cold or as invasive as influenza, the best

offense is a good defense. Coupling a nutritious diet with a program of exercise and routine

supplementation with high quality bovine colostrum is the best possible defense. As we age, our

immune system loses its ability to regulate itself and to respond to a challenge efficiently. This

occurs primarily because the thymus, a glandular structure in the upper chest that is considered the

seat of the immune system, begins to shrink after puberty and almost disappears by the time we

are 50-60 years old. T-lymphocytes (T-cells) are generated from stem cells in the bone marrow and

mature in the thymus. Some of these cells, called Killer T-lymphocytes, generate cell-mediated

responses and directly destroy abnormal cells that have specific sites on their surface that are

recognized by the Killer T- lymphocytes. Helper/Suppressor T-lymphocytes, a second type of cell,

regulate the immune system by controlling the strength and quality of every immune response. It

has been shown that the thymus can be restored to normal function by the growth factors in

colostrum. In addition, colostrum contains specific hormones that regulate the functions of the

thymus and other substances that help to keep the immune system under control and poised to

respond to possible infections before they become established

Ref- 1. Nord J, et al; Treatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patients, AIDS 1990; 4(6):581-4.

2. Rum p JA, et al; Treatment of diarrhea in hum an immunodeficiency virus infected patients with immunoglobulins from bovine colostrum ,

Clin Investig 1992; 70(7):588-94.

3. Kirkpatrick, CH; Activities and characteristics of transfer factors; Biotherapy 1996; 9(1-3): 13-16.

4. Kirkpatrick, CH; Transfer factors: identification of conserved sequences in transfer factor molecules; Mol. Med. 2000 Apr.; 6(4): 332-41.

5. Lawrence, HS, Borkowsk y, W, Transfer factor - current status and future prospects; Biotherap y 1996; 9(1-3):1-5.

6. Lonnerdal B, I yer S; Lactoferrin: molecular structure and biological function, Ann Rev Nutrition 1995; 13:93-110.

7. Brock J; Lactoferrin: a multifunctional immune regulatory protein. Immunol Today 1995; 16(9):417-19.

8. Kussendrager KD, van Hooijdonk AC; Lactoperoxidase: physico-chemical properties, occurrence, mechanism of action and applications,

Brit J Nutr 2000; 84(Suppl 1):S19-25.

9. Gopal PK, Gill HS; Oligosaccharides and glycoconjugates in bovine milk and colostrum , Brit J Nutr 2000; 84(Suppl 1):S69-74.

f. Bovine Colostrum and Metabolic Diseases

Both Types I and II diabetes have an associated genetic component through which individuals

appear to be predisposed. Diabetics also have low levels of IGF-1 in their circulation. Daily

supplementation of the diet of the diabetic patient with high quality first milking bovine colostrum will

provide a functional source for the restoration of diminished levels of IGF-1, resulting in increased

utilization of available glucose. This becomes extremely important for the Type I diabetic to assure

effective and controlled utilization of available glucose once is/her insulin levels are restored. In the

Type II diabetic, where sufficient insulin is available, it has been shown experimentally that

restoration of reduced IGF-1 levels results in an enhancement of glucose utilization with a

corresponding diminution of glucose levels in the blood and urine.

Ref- 10. Spagnoli A, Chiarelli F, Vorwerk P, Boscherini B, Rosenfeld RG; Evaluation of the com ponents of insulin-like growth factor (IGF) and

IGF binding protein (IGFBP) system in adolescents with t ype 1 diabetes and persistent m icroalbum inuria: relationship with increased

excretion of IGFBP - 3 18 kD N-term inal fragm ent, Clin Endocrinol 1999; 51(5): 587-96.

11. Thom as F; Increased weight gain, nitrogen retention and muscle protein synthesis following treatm ent of diabetic rats with IGF-1,

Biochem J 1991; 276(3): 547-54.

12. Skotiner V; Anabolic and tissue repair functions of recom binant insulinlike growth factors, Acta Pediat Scand 1990; 376: S63-6.

13. Steijns JM, van Hooijdonk AC; Occurrence, structure, biochem ical properties and technological characteristics of lactoferrin, Brit J Nutr

2000; 84(Suppl 1):S11-7.

g. Bovine Colostrum and Autoimmune Diseases

Diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, among others, are

complex clinical conditions with variable outcomes. All of the these diseases represent an immune

system that is out of control and could be restored and regulated through routine dietary

supplementation with a high quality first milking colostrum. As indicated above (see Respiratory

Diseases), as we age, our immune system loses its ability to regulate itself efficiently, primarily

because the thymus begins to shrink after puberty and essentially disappears by the time we are

50-60 years old.59,60,61 Scientific studies have shown that the thymus can be restored to normal

function by IGF-1 the levels of which diminish in the circulation with age. In addition, colostrum

contains a) specific hormones, the alpha and beta chains of thymosin, that are known to regulate

the functions of the thymus; and b) proline-rich peptide (PRP), a/k/a thymulin, that has been shown

to keep the immune system under control. It is also well documented that IGF-1 and the associated

Superfamily of proteins found in colostrum operate in concert with growth hormone in the

regeneration and repair of damaged cells.75 Routine dietary supplementation with high quality

bovine colostrum is, therefore, desirable for individuals afflicted with autoimmune diseases in order

to assure that sufficient levels of IGF-1 and growth hormone are continuously available in the

circulation. In addition, since IGF-1 is responsible for directing the conversion of glucose to

glycogen and glycogen is a primary metabolic energy resource, such dietary supplementation could

also help such individuals overcome the associated lethargy normally experienced with such

diseases.

Ref-

14. Nord J, et al; Treatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patients, AIDS 1990; 4(6):581-4.

15. Rum p JA, et al; Treatment of diarrhea in hum an immunodeficiency virus infected patients with immunoglobulins from bovine colostrum,

Clin Investig 1992; 70(7):588-94.

16. Kirkpatrick, CH; Activities and characteristics of transfer factors; Biotherapy 1996; 9(1-3): 13-16.

17. Kirkpatrick, CH; Transfer factors: identification of conserved sequences in transfer factor m olecules; Mol. Med. 2000 Apr.; 6(4): 332-41.

18. Lawrence, HS, Borkowsk y, W ; Transfer factor - current status and future prospects; Biotherap y 1996; 9(1-3):1-5.

h. Bovine Colostrum References

1. In a study by Antonio et al, he and his team examined the effect of 8 weeks of bovine

colostrum supplementation on body composition and exercise performance in active men

and women. There were two groups: a placebo/whey protein group and a bovine colostrum

group. The bovine colostrum group experienced a greater significant increase in lean body

mass than the whey protein group. From this study the scientists recommend that 8 weeks

or more of 20 grams of bovine colostrum will enhance lean muscle hypertrophy which will

further lead to increases in strength and power. This should be especially important and

significant for athletes or anyone interested in advanced human performance and

hypertrophy.

2. In a study by Mero et al their purpose was to examine the effects of bovine colostrum

supplementation on serum insulin-like growth factors (IGF-I), amino acids, and saliva

immunoglobulin concentrations during a strength and speed training period. In this study 9

male subjects were all either advanced sprinters or jumpers. All of them underwent 3

different conditions each lasting a period of 8 days but with a 13 day period between

conditions to eliminate factors from the previous condition. The three conditions were

identical in regards to the sprint and strength training with the only notable difference

amongst them being the type of drink/supplement consumed during the training period.

These conditions included a whey protein supplement, a low level bovine colostrum

supplement, and a high level bovine supplement containing 5 times the amount of colostrum

as the low level group. The results from this study showed a positive correlation between

IGF-I and levels of bovine colostrum. In other words high levels of bovine colostrum

produced the greatest increases in IGF-I. Also the low level bovine colostrum supplement

increased levels of IGF-F to a greater degree than the whey protein group. Finally, if bovine

colostrum can have such positive influence on IFG-I the authors reasonably speculated that

this supplement may have a tremendous effect on athletes due to the anabolic and muscle

building effects of IGF-I.

3. One of the more recent studies regarding bovine colostrum supplementation was again

conducted by Mero and his team of nutritional scientists. In this study the main goal was to

determine the effect of bovine colostrum on serum amino acid concentrations as well as

strength measurements. There were two conditions in which 12 active male subjects

underwent both treatments but with 1 month between each protocol. The two conditions

involved subjects ingesting either a 20 gram bovine colostrum supplement or a 20 gram

placebo/maltodextrin supplement. Measurements were taken before and after each

treatment to determine changes in amino acid concentrations and levels of strength. The

results from this study clearly showed that bovine colostrum produced significant increases

in essential amino acid concentrations within the muscles compared to no increases in the

placebo group. However there were no differences in strength in either group. The authors

theorized that the lack of increases in strength, specifically in the bovine colostrum condition

may be due to the 2 week duration of the study which is relatively short to induce significant

gains in strength.

4. In a study by Buckley et al (62) they examined the effects of bovine colostrum on peak

vertical jump power, peak cycle power, alactic anaerobic work capacity, resistance exercise

one-repetition maximum (1-RM), and plasma insulin-like growth factor (IGF-I)

concentrations. This was an 8 week study composed of 51 males subjects divided into two

groups: a placebo/whey protein group and a bovine colostrum group. Peak vertical jump and

peak anaerobic cycle power both significantly improved in the bovine colostrum group when

compared to the whey group. However, alactic anaerobic work capacity and resistance

exercise one-repetition max changed equally in both groups. Thus the authors noted that

bovine colostrum supplementation worked equally as well as traditional whey protein

powder for certain factors and was superior in eliciting changes in other factors such as

anaerobic power. Simply put, bovine colostrum supplementation during training significantly

increased peak anaerobic power and vertical jump, but had no effect on alactic anaerobic

work capacity, 1RM, or plasma IGF-I when compared to the control/whey protein group.

5. Although many studies have examined human subjects in a laboratory setting, few have

dealt solely with athletic subjects on the playing field especially at the higher level. Hofman

et al did just this. He examined the effect of 8 weeks of supplementation with bovine

colostrum on body composition and exercise performance (5 x 10-m sprint, vertical jump,

shuttle-run test, and suicide test) in elite field hockey players. Seventeen female and 18

male elite field hockey players, including players from the Dutch national team, received

either 60g of colostrum or whey protein daily. The sprint test improved significantly in the

colostrum group versus the placebo/whey group while there was also a slight increase in the

vertical jump performance test for the bovine colostrum group. However, there was no

significant change in body composition or endurance between the two groups. Therefore it

was concluded by the authors of this study that bovine colostrum supplementation may

cause significant improvements in anaerobic power output and explosive capabilities in elite

athletes.

6. Although most studies have found bovine colostrum to be of great aid to power and strength

athletes little has been found or studied in regards to long term endurance performance.

Coombes et al decided to clarify this issue by conducting his own study in which bovine

colostrum was tested on endurance cyclists. In this study there were 42 competitive cyclists

who were randomly divided into three groups and required to consume either 20g a day of

bovine colostrum + 40g whey protein concentrate, 60g of bovine colostrum, or 60g of whey

protein/placebo group. It appears that either of the bovine colostrum protocols elicited

significant gains over the placebo/whey protein group. In other words, the cyclists improved

their two hour time trials by reducing their time by 2-3 minutes over the placebo group. Of

interesting note is that the group which combined 20 grams of bovine colostrum with whey

protein experienced superior outcomes over the group that consumed 60 gram of only

bovine colostrum. Their times were on the average of 30 seconds faster than the 60 grams

bovine colostrum group. Thus it can be surmised that bovine colostrum combined with high

quality whey protein elicits the greatest gains in human performance.

7. Of similar interest to endurance athletes is a study by Shing et al in which he investigated

the influence of low dose bovine colostrum supplementation on exercise performance in

cyclists over a 10 week period that also included 5 days of high intensity training. There

were two groups: a bovine colostrum group which consumed 10 grams a day or a

placebo/whey protein group. High intensity training was not performed until seven weeks

into the endurance program as a means to further improve the cyclist's time trials. The

results before high intensity training during the first seven weeks showed no change.

However, as soon as the five day period of high intensity training was added there was a

significant change between the two groups. The benefits of the bovine colostrum group

although complex and highly scientific were: a 1.9±2.2% improvement from baseline in time

trail performances, a 2.3±6.0% overall increase in time trial intensity (%VO2max), and

maintenance of time trial heart rate (2.5±3.7%). In addition, bovine colostrum

supplementation prevented a decrease in ventilatory threshold following the high intensity

period of training (4.6±4.6%). Simply put, these numbers illustrate how the athletes were

able to improve endurance time trials by slightly altering their physiological makeup with

proper supplementation of bovine colostrum and training. It also appears that bovine

colostrum enhanced the ventilatory system and cardiopulmonary processes by helping them

work more efficiently.

i. Summary and Recommendation

Although there are a relatively few number of research studies performed on bovine colostrum all of

them show empirical evidence of aiding athletic performance. It appears that strength and muscle mass

increases are the most evident results of bovine colostrum supplementation. Some of the other noted

benefits associated with bovine colostrum supplementation include: increased IGF-1 levels, increased

hormone levels, increased peak anaerobic power and vertical jump, reduced endurance times, and

enhanced ventilatory system and cardiopulmonary processes by helping individuals work more

efficiently. It should be noted that bovine colostrum's powerful effect on increasing IGF-1 levels is so

prominent that the NCAA has banned its supplementation for its athletes. Therefore collegiate athletes

should avoid using this product. However, professional athletes may find it highly advantageous to their

performance.

Ref-

1. Gopal PK, Gill HS. Oligosaccharides and glycoconjugates in bovine milk and colostrum. Br J Nutr. 2000; 84: S69-S74.

2. Kelly, G. Bovine Colostrum: A Review of Clinical Uses. Alternative Medicine Review. 2003: Volume 8, Number 4. 378-394.

3. Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and

women. Nutrition. 2001 Mar; 17(3): 243-7.

4. Mero A, Miikkulainen H, Riski J, Pakkanen R, Aalto J, and Takala T. Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA

during training. Journal of Applied Physiology: EXERCISE AND MUSCLE. October 1997. Vol.83, No. 4, 1144-1151.

5. Mero A, Nykanen T, Keinanen O, Knuutinen J, Lahti K, Alen M, Rasi S, Leppaluoto J. Protein metabolism and strength performance after bovine colostrum

supplementation. Amino Acids. 2005 May; 28(3): 327-35.

6. Baechle, T., Earle, R., Essentials of Strength Training and Conditioning. National Strength and Conditioning Association. 2000.

7. Buckley JD, Brinkworth GD, Abbott MJ. Effect of bovine colostrum on anaerobic exercise performance and plasma insulin-like growth factor I. J Sports Sci. 2003

Jul; 21(7): 577-88.

8. What Doctors say about Colostrum?

1. “Probiotics and Colostrum” by Dr. Albert Snow

“Many people take Probiotics without realizing that it is essential to also take colostrum along with

it. Probiotics and colostrum truly go hand in hand. This article will explain why it is so essential to take the

two together. If you are looking to relieve issues like colitis or chronic diarrhea, don’t skimp on taking the

two together. The key to taking these is in knowing which ones to take for the individual & their unique

needs. Taking the wrong ones can at best do nothing & at worst- make you sick. Just one example is if the

person taking either one of these is lactose intolerant. Also there is often times the need to take different

ones at different stages of the treatment. It can get complicated.

The fact is that probiotics are useless without colostrum. They will just go “in one door and out the

other.” Why spend your money on probiotics if they will just be immediately leaving your system? The

reason why colostrum is so essential is that it allows the probiotics to stick to the inner surface of the GI

tissue. This process enables the probiotics to remain permanently in your gut, instead of quickly just

leaving your body.

Of course, if you take antibiotics at any point during your life, this will kill off the friendly bacteria regardless

of whether you have taken it with colostrum or not. In this case, you will need to repeat the cycle over

again from the start and begin a new course of probiotics with colostrum. Different antibiotics require

different probiotics to replace the specific strains that were killed off.

When you were first breastfed, this developed the mucosal lining in your body. This lining is so powerful

that it can last a person’s whole life if he or she doesn’t take antibiotics. Of course, if you were never

breastfed, you will need to take colostrum and probiotics to get this necessary ingredient into your

system. When people are fed soy formulas, they are put at a major disadvantage as far as their health is

concerned.

The fact is that colostrum helps to repair a wide variety of gastrointestinal issues. Oftentimes people take

probiotics for issues like chronic diarrhea treatment or colitis cures and then is disappointed that this

supplementation doesn’t work. When that is the case, the sufferer needs to remember how essential it is

to take the correct colostrum-with the correct probiotic.”

Ref- http://holisticgastroenterology.com/probiotics-and-colostrum

2. “We are so excited about the results we are having from the colostrum. Here are four wonderful

healing results we have to share with you. There are a lot more that will be using this colostrum. This

truly is a wonderful product for those who are fighting to regain health and wholeness. Please share

these healing testimonies with others who need healing.

One young 12 year old boy in California was suffering from a severe case of mucosa colitis and losing

weight. He was literally dying. His doctor was planning surgery to remove his colon. His father called

me and asked what could be done naturally. I recommended that he start taking double doses of

colostrum. After 5 days, the bleeding from the rectum ceased, and within 7 days he began to have

normal bowel movements. From that point on he has gained 32 pounds of weight. His parents were

most delighted to see the change.”

By- Michael McCann, ND. McCann Wellness Center Cottage Grove, Minnesota.

3. “Scientists have long known about the increased resistance of breast-fed babies to certain infections,

particularly to intestinal disorders. However, because of changing cultural values, many post-war

mothers didn’t breast-feed their babies, and now many of these grown-up babies are dealing with

prevalent and difficult-to-treat immune-compromised conditions. Part of this problem is due to the

breakdown of the environment and the nutrient-deficient food we eat. Furthermore, many older people

have fragile immune systems due to a multiplicity of factors, including stress, illness, viruses, diseases,

toxin-laden food and polluted air. Colostrum may well be one of the most important immune system

nutrients to come along in the last 50 years, since more and more illnesses and disease conditions are

linked to a suppressed or compromised immune system.”

By- James Wilson, DC, ND, PhD

4. “[Colostrum's] oral administration, low cost when compared to other current experimental biologic

response modulators, and the absence of side effects are remarkable... To us, as clinicians, the most

valuable aspect of this new therapeutic alternative is its almost miraculous effect on pain

relief...something humanity has always longed for.”

By- Alejandro Nitsch, MD, Guatemala

5. “Bovine colostrum rebuilds the immune system, destroys viruses, bacteria... and fungi, accelerates

healing of all body tissue, helps lose weight, burn fat, increase bone and lean muscle mass, and slows

down and even reverses aging. Colostrum plays a therapeutic role in AIDS, cancer, heart disease,

diabetes, autoimmune diseases, allergies, herpes, bacterial, viral, and parasitic infections, gingivitis,

colds, the flu, and much more. Colostrum has antioxidant and anti-inflammatory properties, and

provides many vitamins, minerals, enzymes, and amino acids”

By- Daniel G. Clark, MD

6. “I have a number of patients who are arthritic, and bovine colostrum dispensed for the treatment of

rheumatoid and osteoarthritis has provided them with amazingly good results. One small-boned elderly

gentleman who was terribly overweight did suffer in total agony from rheumatoid arthritis. He could

hardly walk. I put him on colostrum, about a bottle of 120 capsules per week, and he soon reached the

point where he could walk without pain even though he did not lose the weight.

I used bovine colostrum for the arthritic treatment of my 56 year-old mother. Her left knee exhibited a

lot of inflammation as the result of having been damaged in a prior automobile accident. I had tried a

number of different therapies such as shark cartilage and MSM without success, but when I added the

bovine colostrum she was pain free in three days. She now takes it religiously.

In Mexico, my staff and I do a lot of work with cancer, and two-thirds of my cancer patients are taking

colostrum. About half of my patients are poverty-stricken, and I stretch my resources to help them by

dispensing colostrum to them at little or no cost. For those who can afford it, I typically have them take

five or more 480 milligram capsules a day – that’s over 2000 mg. Colostrum really does seem to make

a beneficial difference for my cancer patients. They have more energy, and it keeps down some of

their infections as a complication of the illness.

I am giving colostrum to hepatitis C patients. One of these people living in Northern California who

found it impossible to come to Mexico consulted me by telephone. His situation was really serious

because he had a hepatitis C viral load of 8 million. I put together a protocol for him of bovine

colostrum, calcium orotate, reduced glutathione and protease enzymes. Within two months, this patient

returned for laboratory testing and discovered that his hepatitis viral load had plummeted to 100. Since

the patient did not take treatment with anything else, this is convincing proof to me that bovine

colostrum works synergistically in a combined nutritional protocol. I’ve gone on to successfully treat

many more cases of hepatitis C.”

By- Stephen Hynes, ND, Dr. Hynes runs a clinic in Ciudad Acuna, Mexico

Ref- http://www.icnr.org/all-about-colostrum/is-colostrum-safe.html

For More Information on Colostrum, Refer-

1. http://www.llli.org/faq/colostrum.html

2. http://www.colostrummax.com/shop2012/index.php?route=information/information&information_id=10

3. http://breastfeeding.about.com/od/breastfeedingbasics/g/colostrum.htm

4. http://www.thefinchleyclinic.com/shop/what-colostrum-a-519.html

5. http://holisticgastroenterology.com/probiotics-and-colostrum

6. http://www.icnr.org/home-page/colostrum-is-safe-and-effective-what-one-of-the-worlds-leading-physicians-has-to-say.html

7. http://www.exrx.net/Nutrition/Supplements/BovineColostrum.html

8. http://www.colostrum.co/colostrum_question.htm

Presenting

For the First Time in India

India’s First Probiotic Brand with High Quality Bovine Colostrum

Most Beneficial Probiotic Bacteria

Available with Vitamin E

Most Delicious American Ice Cream Flavor

“Gastrointestinal Immunity Booster”