Colonic involvement in diffuse lipomatosis
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Transcript of Colonic involvement in diffuse lipomatosis
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induced by interferon alfa–2b did not interfere with this patient’s ability tomount an appropriate leukocytosis with left shift in response to an inflamedappendix. This evidence of immunocompetence despite therapy with in-terferon is probably attributable to the actual role of interferon, reversiblyblocking the release of the white cells from the bone marrow but notarresting the maturation of any cell line. An important factor to acknowl-edge is that the baseline neutropenia that this patient exhibited raises theissue of whether a different criterium for neutropenia for African Ameri-cans should be used. This center is presently involved in a sub–studyreviewing the racial differences in neutropenia in CHC patients on inter-feron therapy.
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COLONIC INVOLVEMENT IN DIFFUSE LIPOMATOSISSusana Lopes, M.D., Guilherme Macedo, M.D., FACG* and FernandoTavarela Veloso, M.D.,Ph.D.,FACG. Gastroenterology Unit, H.S.Joao,Porto, Portugal.
Purpose: A 53 years old female, single, housemaid with mental retarda-tion, had been submitted to hysterectomy and anexectomy 5 years before,and ressection of 2 lipomas, in the dorsum and neck, in the last year . Hergeneral practioner prescribed a barium enema because of recurrent abdom-inal pain and chronic constipation. The Xray report included “..a polypoidformation in the rectum, in the distal third of the sigmoid colon and anotherpolyp in its middle third, that caused an irregular stenosis, which did notallow the barium progression to the proximal colon, suggesting malignantdegeneration..”.
She was referred to us, and throughout the colonoscopy, 3 large polypoidmasses could be seen: they were ovoid, smooth, tender, yellowish, withshort stalk and the covering mucosa was adherent to the mass itself andcould not be isolated with the biopsy forceps. The most proximal, at themiddle third, was the largest, but the scope was able to reach the cecum.There was no other lesions.
At her physical examination, there was a subcutaneous lipoma with 6x4cm long, on the inner aspect of the right tigh, a facial cavernous hema-gioma, and a verruciform lesion on the back of the tongue.
We present the endoscopic features found at the colonoscopy and furthericonography demonstrating her non syndromic diffuse lipomatosis.
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HEPATOBILIARY STRONGYLOIDIASIS: REPORT OF A RARECASE IN AN AIDS PATIENTPriti Pandya, M.D., William L. Riles, M.D., Bashar M. Attar,M.D.,FACG*, Melchor V. Demetria, M.D., Rafid J. Hussein, M.D.,Patricia Simples, M.D. and Bhupat N. Mehta, M.D. Cook CountyHospital, Rush Medical College, Chicago, IL.
Purpose: Hepatobiliary strongyloidiasis is extremely rare. There are only18 cases reported of disseminated strongyloides in HIV patients. AIDScholangiopathy has been reported to be secondary to CMV, cryptospori-diosis, MAC and microsporidiosis, but never secondary to Strongyloidesstercoralis.
A 37–year–old Hispanic female with advanced AIDS and no recenttravel history presented with a one–week history of abdominal pain, nau-sea, vomiting and diarrhea. This was accompanied by shortness of breath,fever, chills, nonproductive cough and a 20 lbs weight loss. Physicalexamination revealed: T 99.7, BP 89/59 mmHg, HR 130, RR 26, andhypoxia. She was dehydrated and cachectic. Her examination was remark-able for bilateral crackles, mild hepatomegaly, and right upper quadranttenderness without rebound and heme positive stool. Laboratory analysisrevealed a Pa O2 of 49, marked normocytic anemia (Hgb of 6.4) but noleukocytosis or eosinophilia. Total bilirubin was 1.4, alkaline phosphataseof 297, GGT 65, AST 89, ALT 76, lipase of 247 and an amylase of 109.Viral hepatitis serologies were negative. CD4 count was 17 with a viralload of 108,937 copies. A CXR showed diffuse bilateral infiltrates. Anultrasound revealed a dilated distal common bile duct (CBD) of 10mm. CTof chest and abdomen showed an acute pneumonitis with chronic interstitialchanges, diffuse hepatomegaly, a slightly edematous pancreas, and a prom-inent CBD. ERCP revealed papillary stenosis, dilated CBD, and friabilityin the duodenum, ampulla, and periampullary region. Biliary brushingswere positive for organisms consistent with Strongyloides stercoralis. Thepatient developed respiratory failure. Subsequent bronchoalveolar lavagewas positive for S. stercoralis. The patient was treated with ivermectin, butcontinued to deteriorate and died. Although infection with Strongyloidesstercoralis is widely prevalent, its association with HIV infection is veryrare with only a few case reports found in the literature. Some patients maybe carriers but hyperinfection of S. stercoralis in our patient was mostlikely precipitated by advanced AIDS (CD4 count: 17). Therefore, in AIDSpatients with cholangiopathy, Strongyloides stercoralis should be consid-ered as part of the differential diagnosis. Eosinophilia is frequently absentand a high index of suspicion is warranted in patients presenting withconcomitant pulmonary and GI/Hepatobiliary symptoms.
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ENDOSCOPIC RESECTION OF A GANGLIOCYTICPARAGANGLIOMA INVOLVING THE AMPULLA OF VATERKlaus Mergener, M.D.*, Marla R. Fenske, M.D. and Richard A.Kozarek, M.D. Section of Gastroenterology, Virginia Mason MedicalCenter, Seattle, WA.
Background: Gangliocytic paragangliomas (GP) are rare neuroendocrinetumors which are typically located in the duodenum but may develop inother areas of the intestine such as the jejunum or the appendix. Wedescribe a patient with a large GP involving the ampulla of Vater, anddescribe endoscopic tumor removal.Case Report: A 53 year old woman presented to another institution witha 2 month history of intermittent melena, a hematocrit of 21. Upperendoscopy after transfusion of 4 units of red cells revealed a large pedun-culated mass involving the ampulla of Vater. ERCP resulted in severepost–ERCP pancreatitis and the patient was transferred to our institution.Endoscopic ultrasound revealed a hypoechoic lesion expanding the sub-mucosa. Due to acute peripancreatic fluid collections she was deemed apoor surgical candidate. She experienced recurrent GI bleeding and it wasdecided to attempt endoscopic management. ERCP revealed a normalpancreatic duct (PD) and common bile duct (CBD). PD and CBD stents
S194 Abstracts AJG – Vol. 97, No. 9, Suppl., 2002