College of PharmacyCollege of Pharmacy

Compounding Interest atCompounding Interest atSummer Pharmacy Summer Pharmacy CampCampCurtis D. Black, Ph.D.

The University of Toledo College of Pharmacy

Presented: July 2005 ~ AACP Annual Meeting

University of Toledo University of Toledo Pharmacy CampPharmacy Camp

OverviewOverview Program initiated in 2001Program initiated in 2001 Sponsored by Walgreens, Sponsored by Walgreens,

CVS/Pharmacy and Discount Drug CVS/Pharmacy and Discount Drug Mart.Mart.

Will welcome 80 high school students Will welcome 80 high school students in July & August 2005.in July & August 2005.

Students are drawn from nine states, Students are drawn from nine states, including Ohio, and represent gender, including Ohio, and represent gender, racial and ethnic diversity.racial and ethnic diversity.

University of Toledo University of Toledo Pharmacy CampPharmacy Camp

GoalsGoals Encourage top performing HS Jrs/Srs to Encourage top performing HS Jrs/Srs to

pursue study in the health sciencespursue study in the health sciences Provide exposure to the many career Provide exposure to the many career

opportunities in pharmaceutical sciences opportunities in pharmaceutical sciences Blend lecture presentations with hands-on Blend lecture presentations with hands-on

experiences through a unifying themeexperiences through a unifying theme Engage the students in problem-solving Engage the students in problem-solving

exercises that instill the concepts of exercises that instill the concepts of effective interpersonal communicationseffective interpersonal communications

University of Toledo University of Toledo Pharmacy CampPharmacy Camp

Sample AgendaSample Agenda

Theme: Controlling Pain Theme: Controlling Pain Sunday PM arrivalSunday PM arrival

Check-in & Review of program goalsCheck-in & Review of program goals ““Getting-to-Know” you exercises Getting-to-Know” you exercises MealMeal Overview of Project ActivityOverview of Project Activity Games, Movies & SnacksGames, Movies & Snacks

University of Toledo University of Toledo Pharmacy CampPharmacy Camp

Sample AgendaSample Agenda Monday AMMonday AM

Pharmacology Lecture & DiscussionPharmacology Lecture & Discussion• What makes a drug work?What makes a drug work?• Why so many drugs to alleviate pain?Why so many drugs to alleviate pain?• How to decide best drug to use?How to decide best drug to use?• What testing is done before a drug comes What testing is done before a drug comes

to market?to market? Tie into theme and health awareness Tie into theme and health awareness

projectsprojects Proper OTC selection & useProper OTC selection & use Know your medicines: esp., relative to recalls Know your medicines: esp., relative to recalls Drugs of abuseDrugs of abuse

University of Toledo University of Toledo Pharmacy CampPharmacy Camp

Sample AgendaSample Agenda Monday PMMonday PM

Toxicology DiscussionToxicology Discussion • What are basic principles of toxicology?What are basic principles of toxicology?• How do you determine the negative effects?How do you determine the negative effects?• Animal vs. human testingAnimal vs. human testing• What information is collected before and What information is collected before and

after a drug comes to market?after a drug comes to market? Toxicology Lab /Hands-on ParticipationToxicology Lab /Hands-on Participation

• Lab experiment determining toxicity profileLab experiment determining toxicity profile Tie into theme and health awareness Tie into theme and health awareness

projectsprojects How to find information about health issues and How to find information about health issues and

approach to drug therapyapproach to drug therapy Drug information software demonstration and Drug information software demonstration and

guided search strategiesguided search strategies

University of Toledo University of Toledo Pharmacy CampPharmacy Camp

Sample AgendaSample Agenda Tuesday AMTuesday AM

Pharmaceutics & Compounding LabPharmaceutics & Compounding Lab• Why so many different types of dosage forms?Why so many different types of dosage forms?

– Focus on analgesics: tabs, “liqui-caps”, injectablesFocus on analgesics: tabs, “liqui-caps”, injectables• Providing customized products for unique Providing customized products for unique

patient needspatient needs Prepare oral lozenge (Peanut butter troche)Prepare oral lozenge (Peanut butter troche) Prepare hand cleanser/sanitizer (~ Prepare hand cleanser/sanitizer (~ PurellPurell))

Medicinal Plant HuntMedicinal Plant Hunt Trip to Botanical GardenTrip to Botanical Garden List of Plants to Find & Uses – focus on themeList of Plants to Find & Uses – focus on theme

University of Toledo University of Toledo Pharmacy CampPharmacy Camp

Sample AgendaSample Agenda Tuesday PMTuesday PM

Medicinal Chemistry Lecture & DemoMedicinal Chemistry Lecture & Demo• What is history of medicinal plants?What is history of medicinal plants?• How prevalent are natural remedies?How prevalent are natural remedies?• What are problems associated with natural What are problems associated with natural

remedies?remedies? Role of medicinal chemistry lab is isolating, Role of medicinal chemistry lab is isolating,

refining and standardizing natural products refining and standardizing natural products Lab exercise in isolating chemical Lab exercise in isolating chemical

componentscomponents Work on ProjectWork on Project

University of Toledo University of Toledo Pharmacy CampPharmacy Camp

Sample AgendaSample Agenda Wednesday AMWednesday AM

Professional ShadowingProfessional Shadowing• Institutional & Community Retail SitesInstitutional & Community Retail Sites• Compounding Pharmacy/Vet Product PreparationCompounding Pharmacy/Vet Product Preparation• Consultant PharmacyConsultant Pharmacy

– Gain insight on project from preceptor Gain insight on project from preceptor

Wednesday PMWednesday PM Patient Education & Public AwarenessPatient Education & Public Awareness

• Defining the role of the pharmacist as educatorDefining the role of the pharmacist as educator• Good, Bad & Ugly of pharmacist-patient Good, Bad & Ugly of pharmacist-patient

encountersencounters

University of Toledo University of Toledo Pharmacy CampPharmacy Camp

Sample AgendaSample Agenda ThursdayThursday

Finalize project and prepare for Finalize project and prepare for presentationpresentation

Evaluation of the experienceEvaluation of the experience Closing Day Ceremonies Closing Day Ceremonies

• Student Group PresentationsStudent Group Presentations• Dean’s Presentation of Certificates of Dean’s Presentation of Certificates of

RecognitionRecognition• Admissions Office Pep TalkAdmissions Office Pep Talk• LunchLunch• Check OutCheck Out

Value:Value: Exploring Hands-onExploring Hands-on

Value:Value: Making FriendsMaking Friends

OutcomesOutcomes

Annually, more than 50% of campers Annually, more than 50% of campers enroll in the college with about 80% enroll in the college with about 80% successfully competing for scholarships.successfully competing for scholarships.

First cohort now matriculating into the First cohort now matriculating into the second professional yearsecond professional year

Some have chosen other majors, Some have chosen other majors, revealing the value of early exposure to revealing the value of early exposure to pharmacy and some aspects of pharmacy and some aspects of pharmacy courses.pharmacy courses.

AcknowledgementsAcknowledgements

2005 Camp Director: Laurel Seewer2005 Camp Director: Laurel Seewer Founding Director: Jennifer KwiatkowskiFounding Director: Jennifer Kwiatkowski Christine Hinko, Ph.D.: Christine Hinko, Ph.D.: Assoc Dean, Student Assoc Dean, Student

ServicesServices Johnnie L. Early, II: Dean, UTCP Johnnie L. Early, II: Dean, UTCP Heather Van Doren: Heather Van Doren: College PR OfficerCollege PR Officer

and our Sponsors:and our Sponsors:

Formula for Formula for demonstrationdemonstrationStep 1Step 1 Prepare a 2% solution of Carbomer in Prepare a 2% solution of Carbomer in

30% ethanol30% ethanol Using either Carbomer 934 or 940, stir the Using either Carbomer 934 or 940, stir the

appropriate amount of polymer into a appropriate amount of polymer into a volume of water equal to 70% of final volume of water equal to 70% of final desired volumedesired volume

• May require up to eight hours of stirring for May require up to eight hours of stirring for complete dissolutioncomplete dissolution

Add the ethanol (to a 30% concentration) Add the ethanol (to a 30% concentration) and q.s. to final desired volume with water.and q.s. to final desired volume with water.

Pour into an amber light-protected Pour into an amber light-protected container and labelcontainer and label

Formula for Formula for demonstrationdemonstrationStep 2Step 2 Prepare a 2.5% solution of Prepare a 2.5% solution of

Triethanolamine in waterTriethanolamine in water Measure the appropriate amount (Measure the appropriate amount (relative relative

to final desired volumeto final desired volume) of triethanolamine ) of triethanolamine and pour into a suitable containerand pour into a suitable container

Add water q.s.’ing to final desired volumeAdd water q.s.’ing to final desired volume Stir in a small amount of phenolphthalein Stir in a small amount of phenolphthalein

to desired color intensityto desired color intensity Pour into a suitable container and labelPour into a suitable container and label

Formula for Formula for demonstrationdemonstrationStep 3Step 3 For the demonstration:For the demonstration:

The participants will mix the Carbomer solution The participants will mix the Carbomer solution with the Triethanolamine solution in a 2:1 ratiowith the Triethanolamine solution in a 2:1 ratio

Using 15 ml of Carbomer solution and 7.5 ml of Using 15 ml of Carbomer solution and 7.5 ml of the triethanolamine solution makes a sufficient the triethanolamine solution makes a sufficient amount of product for 2-3 people to share.amount of product for 2-3 people to share.

The demonstration works best with people The demonstration works best with people working in pairs or threesomes. working in pairs or threesomes.

To make the total demonstration go smoothly, To make the total demonstration go smoothly, pre-measure the solutions and place each in a pre-measure the solutions and place each in a small, resealable plastic bagsmall, resealable plastic bag

Formula for Formula for demonstrationdemonstrationNotesNotes Having the participants pour the Having the participants pour the

triethanolamine solution into the bag triethanolamine solution into the bag containing the carbomer usually makes the containing the carbomer usually makes the most dramatic effect; most dramatic effect; i.e., seeing the color and i.e., seeing the color and consistency changeconsistency change

The resealable plastic bags work well when The resealable plastic bags work well when mixing the solutions together to render the mixing the solutions together to render the final product; final product; i.e., can vigorously squeeze the i.e., can vigorously squeeze the bagsbags

Can either cut a corner off the bottom of the Can either cut a corner off the bottom of the bag to access the product or reopen the bag bag to access the product or reopen the bag and reach in.and reach in. Product much like PurellProduct much like Purell®® Gel Gel