ccoobbaass ee 411 analyzerConfidence in every result .

Accurate Results• ECL technology delivers excellent low-end sensitivity and

broad dynamic ranges

Quality Results• Assay-specific QC confidence intervals to determine

calibration

• Improved tracking capabilities for QC patient samples and calibrator materials

• Disposable tips and cups reduce the potential for carryover

Standardization• Uniform reagent carriers, applications, analytical

technologies, and software interface with cobas® analyzers

Control• Improve your labs’ financial performance, enhance efficiency,

and make a difference for the doctors and patients who rely on the critical information to make vital decisions about healthcare, every day.

The ccoobbaass ee 411 analyzer offers...

17591_Brochure.qxd 11/1/06 10:46 AM Page 2

Control Unit— Microsoft® Windows® XP

based user-interface

— Color LCD touch-screen

— Pentium processor

ccoobbaass ee 411 Analyzer— ECL technology

— Throughput: up to 86 tests per hour

— 18 channels (reagent slots), temperature controlled at 20°C

— Clot detection (pressure sensor) and liquid level detection (capacitance)

— Disposable AssayTip for carry-over free sample pipetting

— Disposable AssayCup utilized as reaction vessel

— Automatic sample dilution upon operator request

— 100 / 200 test packs

ccoobbaass ee 411 analyzer

Roche ECLmeasuring range

Chemiluminescencemeasuring range

Roche Diagnostics Electrochemiluminescence (ECL)

Chemiluminescence (CL)

ECL extended measuring range ECL technology for accurate results the first timeElectrochemiluminescence (ECL), a sophisticated technology used in Rocheimmunoassays, delivers excellent low-end sensitivity and broad dynamicranges. The measuring cell uses an amplified signal to detect ultra-lowconcentrations of analyte. By precisely controlling electrically-initiatedreactions, ECL technology virtually eliminates unnecessary repeats and reruns,providing accurate results the first time.

ccoobbaass ee 411 analyzer user interfaceThe user interface provides specimen control and data management from aneasy-to-navigate, Microsoft® Widows® XP based LCD touch-screen.

STAT turnaround timeResults in 9 minutes for critical tests such as Troponin T, CK-MB, Myoglobin,and HCG–33% faster than other systems.

Unique no-prep reagent concept delivers greater convenience

The cobas e packs are ready-to-use, eliminating hands-on time, and are common to other Roche systems, reducing storage and inventory requirements.Closed for protection against environmental elements, the cobas e packs haveself-sealing lids that increase onboard stability.

operatorinterface

— Reduced complexity

— Results in real time

— Programmable for customization

5-positionsample rack

— Universal, color-coded, compatible with other Roche systems

— Accommodates multiple tube sizes without adapters

— Provides efficient routing of samples

sample process

— Disposable assay tips

— Clot detection

— Liquid level detection

e packreagents

— 100-200 tests per e pack

— Ready-to-use; 60-day mean onboard stability

— Unique package design reduces inventory, eliminates reagent preparation and minimizes calibration time

— 2-D barcodes eliminate the need for manual entry of application and reagent data

reagent compartment

— 18 reagent channels

— Temperature controlled

— Random reagent placement

— Automatic reagent registration

— Automatic bottle changeover

— Automatic calibration notification

— Up to 8 weeks stability

Microsoft is a trademarkofMicrosoft Corporation. Pentium is a trademarkofIntel Corporation.COBAS, COBAS E, ELECSYS and LIFENEEDS ANSWERS are trademarks ofRoche.

Roche Diagnostics9115 Hague RoadIndianapolis, IN 46256http://us.labsystems.roche.com

©2006 Roche Diagnostics. All rights reserved. 491_29744_1006

ccoobbaass ee 411analyzer–Technical Specifications

System Fully automated, multi-channel immunoas-say analyzer for random access processingof ECL based immuno assays (Elecsys®system format)

System ComponentsSelf contained bench top analyzer compris-ing an analytical unit and a customizeduser interface

Sample Throughput Up to 86 samples per hour

Test Throughput86 results per hour (steady state mode,(theoretical max)only 18 min assays)

Numberof Channels18 channels (reagent slots) for maximum of 18 different chemistries

ProgrammableN/A, programming-by-loading (PBT)Parametersconcept, application data are transferred

without operator intervention from the 2Dbarcode of the reagent pack (RP) into theinstrument database

Sample MaterialSerum/plasma, urine, others

Sample Input/OutputDisk: 30 positions for samples, calibrators and controls

Rack: 15 racks with 5 samples each (= 75 samples in/out)

STAT port: STAT samples are processed with priority

Sample Volume10 – 50 µl

Sample DilutionOnboard, user definable, 1 or 2 step, max 1:400

Sample Clot DetectionAvailable (pressure sensor)

Sample Barcode TypesCode 128Codabar (NW 7)Interleaved 2 of 5Code 39

Control UnitPanel PC

System InterfacesRS 232 serial interface, bi-directional

Sample Data Base2,000 results (samples and QC)

Calibrator/QC InputElecsys®

system specific barcoded CalSetvials on disk or racks

Calibration MethodsLot calibration (L-cal) Reagent Pack (RP) calibration (R-Cal)

QC MethodsIndividual QC and cumulative QC

Up to 100 controls pre-programmable

Preventive QC after calibration of the stand-by cobas epacks

Rerun/Reflex FunctionManual rerun

Electrical RequirementsPower requirements: 230 Volts AC110 Volts AC1,000 kVA (disk), 1,250 kVA (rack)

Frequency: 50 Hz or 60 Hz +/- 0.5 %

Water/WasteWater: Bacteria free, deionised waterRequirementssupply, resistance of < 10 µS/cm

Water consumption:Liquid waste:Onboard waste container (4 liter), direct drain optional

Regulatory and SafetyGS, CE, UL, c-UL, EN/IEC 61010-2-101,RequirementsCB certificate

Operating ConditionsAmbient temperature: 18 to 32º C

Ambient humidity: 20 to 80% (RH, without condensation)

Heat Output:2,879 kJ/hr (analyzer unit)

Noise Output:60 dBA (stand-by),63 dBA (operation avg.)

Physical DimensionsWidth (disk/rack):120 cm / 170 cm47.2 in / 67 in

Depth (disk/rack):73 cm / 95 cm28.7 in / 37.4 in

Height: 80 cm / 31.4 in (closed top cover)109 cm / 43 in (opened top cover)

WeightDisk: 180 kg / 397 lbs

Rack: 250 kg / 551 lbs

17591_Brochure.qxd 11/1/06 10:46 AM Page 1

Control Unit— Microsoft® Windows® XP

based user-interface

— Color LCD touch-screen

— Pentium processor

ccoobbaass ee 411 Analyzer— ECL technology

— Throughput: up to 86 tests per hour

— 18 channels (reagent slots), temperature controlled at 20°C

— Clot detection (pressure sensor) and liquid level detection (capacitance)

— Disposable AssayTip for carry-over free sample pipetting

— Disposable AssayCup utilized as reaction vessel

— Automatic sample dilution upon operator request

— 100 / 200 test packs

ccoobbaass ee 411 analyzer

Roche ECLmeasuring range

Chemiluminescencemeasuring range

Roche Diagnostics Electrochemiluminescence (ECL)

Chemiluminescence (CL)

ECL extended measuring range ECL technology for accurate results the first timeElectrochemiluminescence (ECL), a sophisticated technology used in Rocheimmunoassays, delivers excellent low-end sensitivity and broad dynamicranges. The measuring cell uses an amplified signal to detect ultra-lowconcentrations of analyte. By precisely controlling electrically-initiatedreactions, ECL technology virtually eliminates unnecessary repeats and reruns,providing accurate results the first time.

ccoobbaass ee 411 analyzer user interfaceThe user interface provides specimen control and data management from aneasy-to-navigate, Microsoft® Widows® XP based LCD touch-screen.

STAT turnaround timeResults in 9 minutes for critical tests such as Troponin T, CK-MB, Myoglobin,and HCG–33% faster than other systems.

Unique no-prep reagent concept delivers greater convenience

The cobas e packs are ready-to-use, eliminating hands-on time, and are common to other Roche systems, reducing storage and inventory requirements.Closed for protection against environmental elements, the cobas e packs haveself-sealing lids that increase onboard stability.

operatorinterface

— Reduced complexity

— Results in real time

— Programmable for customization

5-positionsample rack

— Universal, color-coded, compatible with other Roche systems

— Accommodates multiple tube sizes without adapters

— Provides efficient routing of samples

sample process

— Disposable assay tips

— Clot detection

— Liquid level detection

e packreagents

— 100-200 tests per e pack

— Ready-to-use; 60-day mean onboard stability

— Unique package design reduces inventory, eliminates reagent preparation and minimizes calibration time

— 2-D barcodes eliminate the need for manual entry of application and reagent data

reagent compartment

— 18 reagent channels

— Temperature controlled

— Random reagent placement

— Automatic reagent registration

— Automatic bottle changeover

— Automatic calibration notification

— Up to 8 weeks stability

Microsoft is a trademarkofMicrosoft Corporation. Pentium is a trademarkofIntel Corporation.COBAS, COBAS E, ELECSYS and LIFENEEDS ANSWERS are trademarks ofRoche.

Roche Diagnostics9115 Hague RoadIndianapolis, IN 46256http://us.labsystems.roche.com

©2006 Roche Diagnostics. All rights reserved. 491_29744_1006

ccoobbaass ee 411analyzer–Technical Specifications

System Fully automated, multi-channel immunoas-say analyzer for random access processingof ECL based immuno assays (Elecsys®system format)

System ComponentsSelf contained bench top analyzer compris-ing an analytical unit and a customizeduser interface

Sample Throughput Up to 86 samples per hour

Test Throughput86 results per hour (steady state mode,(theoretical max)only 18 min assays)

Numberof Channels18 channels (reagent slots) for maximum of 18 different chemistries

ProgrammableN/A, programming-by-loading (PBT)Parametersconcept, application data are transferred

without operator intervention from the 2Dbarcode of the reagent pack (RP) into theinstrument database

Sample MaterialSerum/plasma, urine, others

Sample Input/OutputDisk: 30 positions for samples, calibrators and controls

Rack: 15 racks with 5 samples each (= 75 samples in/out)

STAT port: STAT samples are processed with priority

Sample Volume10 – 50 µl

Sample DilutionOnboard, user definable, 1 or 2 step, max 1:400

Sample Clot DetectionAvailable (pressure sensor)

Sample Barcode TypesCode 128Codabar (NW 7)Interleaved 2 of 5Code 39

Control UnitPanel PC

System InterfacesRS 232 serial interface, bi-directional

Sample Data Base2,000 results (samples and QC)

Calibrator/QC InputElecsys®

system specific barcoded CalSetvials on disk or racks

Calibration MethodsLot calibration (L-cal) Reagent Pack (RP) calibration (R-Cal)

QC MethodsIndividual QC and cumulative QC

Up to 100 controls pre-programmable

Preventive QC after calibration of the stand-by cobas epacks

Rerun/Reflex FunctionManual rerun

Electrical RequirementsPower requirements: 230 Volts AC110 Volts AC1,000 kVA (disk), 1,250 kVA (rack)

Frequency: 50 Hz or 60 Hz +/- 0.5 %

Water/WasteWater: Bacteria free, deionised waterRequirementssupply, resistance of < 10 µS/cm

Water consumption:Liquid waste:Onboard waste container (4 liter), direct drain optional

Regulatory and SafetyGS, CE, UL, c-UL, EN/IEC 61010-2-101,RequirementsCB certificate

Operating ConditionsAmbient temperature: 18 to 32º C

Ambient humidity: 20 to 80% (RH, without condensation)

Heat Output:2,879 kJ/hr (analyzer unit)

Noise Output:60 dBA (stand-by),63 dBA (operation avg.)

Physical DimensionsWidth (disk/rack):120 cm / 170 cm47.2 in / 67 in

Depth (disk/rack):73 cm / 95 cm28.7 in / 37.4 in

Height: 80 cm / 31.4 in (closed top cover)109 cm / 43 in (opened top cover)

WeightDisk: 180 kg / 397 lbs

Rack: 250 kg / 551 lbs

17591_Brochure.qxd 11/1/06 10:46 AM Page 1

Control Unit— Microsoft® Windows® XP

based user-interface

— Color LCD touch-screen

— Pentium processor

ccoobbaass ee 411 Analyzer— ECL technology

— Throughput: up to 86 tests per hour

— 18 channels (reagent slots), temperature controlled at 20°C

— Clot detection (pressure sensor) and liquid level detection (capacitance)

— Disposable AssayTip for carry-over free sample pipetting

— Disposable AssayCup utilized as reaction vessel

— Automatic sample dilution upon operator request

— 100 / 200 test packs

ccoobbaass ee 411 analyzer

Roche ECLmeasuring range

Chemiluminescencemeasuring range

Roche Diagnostics Electrochemiluminescence (ECL)

Chemiluminescence (CL)

ECL extended measuring range ECL technology for accurate results the first timeElectrochemiluminescence (ECL), a sophisticated technology used in Rocheimmunoassays, delivers excellent low-end sensitivity and broad dynamicranges. The measuring cell uses an amplified signal to detect ultra-lowconcentrations of analyte. By precisely controlling electrically-initiatedreactions, ECL technology virtually eliminates unnecessary repeats and reruns,providing accurate results the first time.

ccoobbaass ee 411 analyzer user interfaceThe user interface provides specimen control and data management from aneasy-to-navigate, Microsoft® Widows® XP based LCD touch-screen.

STAT turnaround timeResults in 9 minutes for critical tests such as Troponin T, CK-MB, Myoglobin,and HCG–33% faster than other systems.

Unique no-prep reagent concept delivers greater convenience

The cobas e packs are ready-to-use, eliminating hands-on time, and are common to other Roche systems, reducing storage and inventory requirements.Closed for protection against environmental elements, the cobas e packs haveself-sealing lids that increase onboard stability.

operatorinterface

— Reduced complexity

— Results in real time

— Programmable for customization

5-positionsample rack

— Universal, color-coded, compatible with other Roche systems

— Accommodates multiple tube sizes without adapters

— Provides efficient routing of samples

sample process

— Disposable assay tips

— Clot detection

— Liquid level detection

e packreagents

— 100-200 tests per e pack

— Ready-to-use; 60-day mean onboard stability

— Unique package design reduces inventory, eliminates reagent preparation and minimizes calibration time

— 2-D barcodes eliminate the need for manual entry of application and reagent data

reagent compartment

— 18 reagent channels

— Temperature controlled

— Random reagent placement

— Automatic reagent registration

— Automatic bottle changeover

— Automatic calibration notification

— Up to 8 weeks stability

Microsoft is a trademarkofMicrosoft Corporation. Pentium is a trademarkofIntel Corporation.COBAS, COBAS E, ELECSYS and LIFENEEDS ANSWERS are trademarks ofRoche.

Roche Diagnostics9115 Hague RoadIndianapolis, IN 46256http://us.labsystems.roche.com

©2006 Roche Diagnostics. All rights reserved. 491_29744_1006

ccoobbaass ee 411analyzer–Technical Specifications

System Fully automated, multi-channel immunoas-say analyzer for random access processingof ECL based immuno assays (Elecsys®system format)

System ComponentsSelf contained bench top analyzer compris-ing an analytical unit and a customizeduser interface

Sample Throughput Up to 86 samples per hour

Test Throughput86 results per hour (steady state mode,(theoretical max)only 18 min assays)

Numberof Channels18 channels (reagent slots) for maximum of 18 different chemistries

ProgrammableN/A, programming-by-loading (PBT)Parametersconcept, application data are transferred

without operator intervention from the 2Dbarcode of the reagent pack (RP) into theinstrument database

Sample MaterialSerum/plasma, urine, others

Sample Input/OutputDisk: 30 positions for samples, calibrators and controls

Rack: 15 racks with 5 samples each (= 75 samples in/out)

STAT port: STAT samples are processed with priority

Sample Volume10 – 50 µl

Sample DilutionOnboard, user definable, 1 or 2 step, max 1:400

Sample Clot DetectionAvailable (pressure sensor)

Sample Barcode TypesCode 128Codabar (NW 7)Interleaved 2 of 5Code 39

Control UnitPanel PC

System InterfacesRS 232 serial interface, bi-directional

Sample Data Base2,000 results (samples and QC)

Calibrator/QC InputElecsys®

system specific barcoded CalSetvials on disk or racks

Calibration MethodsLot calibration (L-cal) Reagent Pack (RP) calibration (R-Cal)

QC MethodsIndividual QC and cumulative QC

Up to 100 controls pre-programmable

Preventive QC after calibration of the stand-by cobas epacks

Rerun/Reflex FunctionManual rerun

Electrical RequirementsPower requirements: 230 Volts AC110 Volts AC1,000 kVA (disk), 1,250 kVA (rack)

Frequency: 50 Hz or 60 Hz +/- 0.5 %

Water/WasteWater: Bacteria free, deionised waterRequirementssupply, resistance of < 10 µS/cm

Water consumption:Liquid waste:Onboard waste container (4 liter), direct drain optional

Regulatory and SafetyGS, CE, UL, c-UL, EN/IEC 61010-2-101,RequirementsCB certificate

Operating ConditionsAmbient temperature: 18 to 32º C

Ambient humidity: 20 to 80% (RH, without condensation)

Heat Output:2,879 kJ/hr (analyzer unit)

Noise Output:60 dBA (stand-by),63 dBA (operation avg.)

Physical DimensionsWidth (disk/rack):120 cm / 170 cm47.2 in / 67 in

Depth (disk/rack):73 cm / 95 cm28.7 in / 37.4 in

Height: 80 cm / 31.4 in (closed top cover)109 cm / 43 in (opened top cover)

WeightDisk: 180 kg / 397 lbs

Rack: 250 kg / 551 lbs

17591_Brochure.qxd 11/1/06 10:46 AM Page 1

ccoobbaass ee 411 analyzerConfidence in every result .

Accurate Results• ECL technology delivers excellent low-end sensitivity and

broad dynamic ranges

Quality Results• Assay-specific QC confidence intervals to determine

calibration

• Improved tracking capabilities for QC patient samples and calibrator materials

• Disposable tips and cups reduce the potential for carryover

Standardization• Uniform reagent carriers, applications, analytical

technologies, and software interface with cobas® analyzers

Control• Improve your labs’ financial performance, enhance efficiency,

and make a difference for the doctors and patients who rely on the critical information to make vital decisions about healthcare, every day.

The ccoobbaass ee 411 analyzer offers...

17591_Brochure.qxd 11/1/06 10:46 AM Page 2

Control Unit— Microsoft® Windows® XP

based user-interface

— Color LCD touch-screen

— Pentium processor

ccoobbaass ee 411Analyzer— ECL technology

— Throughput:up to 86 tests per hour

— 18 channels (reagent slots),temperature controlled at 20°C

— Clot detection (pressure sensor) and liquid level detection (capacitance)

— Disposable AssayTip for carry-over free sample pipetting

— Disposable AssayCup utilized as reaction vessel

— Automatic sample dilution upon operator request

— 100 / 200 test packs

ccoobbaassee411analyzer

Roche ECLmeasuring range

Chemiluminescencemeasuring range

Roche Diagnostics Electrochemiluminescence (ECL)

Chemiluminescence (CL)

ECL extended measuring rangeECLtechnology foraccurate results the first time

Electrochemiluminescence (ECL),a sophisticated technology used in Rocheimmunoassays,delivers excellent low-end sensitivity and broad dynamicranges.The measuring cell uses an amplified signal to detect ultra-lowconcentrations ofanalyte.By precisely controlling electrically-initiatedreactions,ECL technology virtually eliminates unnecessary repeats and reruns,providing accurate results the first time.

ccoobbaass ee 411analyzeruserinterfaceThe user interface provides specimen control and data management from aneasy-to-navigate,Microsoft® Widows® XP based LCD touch-screen.

STATturnaround timeResults in 9 minutes for critical tests such as Troponin T,CK-MB,Myoglobin,and HCG–33% faster than other systems.

Unique no-prep reagent concept delivers greaterconvenience

The cobas epacks are ready-to-use,eliminating hands-on time,and are common to other Roche systems,reducing storage and inventory requirements.Closed for protection against environmental elements,the cobas epacks haveself-sealing lids that increase onboard stability.

operatorinterface

— Reduced complexity

— Results in real time

— Programmable for customization

5-positionsample rack

— Universal,color-coded,compatible with other Roche systems

— Accommodates multiple tube sizes without adapters

— Provides efficient routing ofsamples

sample process

— Disposable assay tips

— Clot detection

— Liquid level detection

e packreagents

— 100-200 tests per e pack

— Ready-to-use; 60-day mean onboard stability

— Unique package design reduces inventory,eliminates reagent preparation and minimizes calibration time

— 2-D barcodes eliminate the need for manual entry ofapplication and reagent data

reagent compartment

— 18 reagent channels

— Temperature controlled

— Random reagent placement

— Automatic reagent registration

— Automatic bottle changeover

— Automatic calibration notification

— Up to 8 weeks stability

Microsoft is a trademark of Microsoft Corporation. Pentium is a trademark of Intel Corporation.COBAS, COBAS E, ELECSYS and LIFE NEEDS ANSWERS are trademarks of Roche.

Roche Diagnostics9115 Hague RoadIndianapolis, IN 46256http://us.labsystems.roche.com

©2006 Roche Diagnostics. All rights reserved. 491_29744_1006

ccoobbaass ee 411 analyzer –Technical Specifications

System Fully automated, multi-channel immunoas-say analyzer for random access processingof ECL based immuno assays (Elecsys®system format)

System Components Self contained bench top analyzer compris-ing an analytical unit and a customizeduser interface

Sample Throughput Up to 86 samples per hour

Test Throughput 86 results per hour (steady state mode,(theoretical max) only 18 min assays)

Number of Channels 18 channels (reagent slots) for maximum of 18 different chemistries

Programmable N/A, programming-by-loading (PBT)Parameters concept, application data are transferred

without operator intervention from the 2Dbarcode of the reagent pack (RP) into theinstrument database

Sample Material Serum/plasma, urine, others

Sample Input/Output Disk: 30 positions for samples, calibrators and controls

Rack: 15 racks with 5 samples each (= 75 samples in/out)

STAT port: STAT samples are processed with priority

Sample Volume 10 – 50 µl

Sample Dilution Onboard, user definable, 1 or 2 step, max 1:400

Sample Clot Detection Available (pressure sensor)

Sample Barcode Types Code 128Codabar (NW 7)Interleaved 2 of 5Code 39

Control Unit Panel PC

System Interfaces RS 232 serial interface, bi-directional

Sample Data Base 2,000 results (samples and QC)

Calibrator/QC Input Elecsys® system specific barcoded CalSetvials on disk or racks

Calibration Methods Lot calibration (L-cal) Reagent Pack (RP) calibration (R-Cal)

QC Methods Individual QC and cumulative QC

Up to 100 controls pre-programmable

Preventive QC after calibration of the stand-by cobas e packs

Rerun/Reflex Function Manual rerun

Electrical Requirements Power requirements: 230 Volts AC110 Volts AC1,000 kVA (disk), 1,250 kVA (rack)

Frequency: 50 Hz or 60 Hz +/- 0.5 %

Water/Waste Water: Bacteria free, deionised waterRequirements supply, resistance of < 10 µS/cm

Water consumption:Liquid waste: Onboard waste container (4 liter), direct drain optional

Regulatory and Safety GS, CE, UL, c-UL, EN/IEC 61010-2-101,Requirements CB certificate

Operating Conditions Ambient temperature: 18 to 32º C

Ambient humidity: 20 to 80% (RH, without condensation)

Heat Output: 2,879 kJ/hr (analyzer unit)

Noise Output: 60 dBA (stand-by),63 dBA (operation avg.)

Physical Dimensions Width (disk/rack): 120 cm / 170 cm47.2 in / 67 in

Depth (disk/rack): 73 cm / 95 cm28.7 in / 37.4 in

Height: 80 cm / 31.4 in (closed top cover)109 cm / 43 in (opened top cover)

Weight Disk: 180 kg / 397 lbs

Rack: 250 kg / 551 lbs

17591_Brochure.qxd 11/1/06 10:46 AM Page 1