Cobalt in Organic Synthesis - Thieme Connect · HCo(PMe3)4 5 mol% HBPin Take one get one Take two...
Transcript of Cobalt in Organic Synthesis - Thieme Connect · HCo(PMe3)4 5 mol% HBPin Take one get one Take two...
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Cover Page Special TopicSyn thesis
SYNTHESIS0 0 3 9 - 7 8 8 1 1 4 3 7 - 2 1 0 X© Georg Thieme Verlag Stuttgart · New York2017, 49, 3885–3886special topicen
Sandwiched between iron and nickel, cobalt has not always enjoyed the interest that has beenshowered on its more famous neighbors. Yet the last few years has seen a steady rise in inter-est in cobalt-catalyzed transformations. The fact that it is considered a base metal makes itparticularly attractive when it may replace rarer, more expensive metals. More importantly, itis increasingly credited with facilitating a wide range of modern transformations in syntheticchemistry. These include: the venerable Pauson–Khand annulation, substitution reactions,epoxide opening, Mannich additions, arene couplings, functionalization of quinolines, hydro-boration, and C–H functionalization. SYNTHESIS and Thieme are proud to provide in this SpecialTopic a curated collection of reports describing important advances in chemistry mediated bycobalt and its complexes. We trust the readers will enjoy the cutting edge chemistry found inthis issue and be inspired to innovate!
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Erick M. Carreira Editor ETH Zürich, Switzerland
Published as part of the Special Topic Cobalt in OrganicSynthesis
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© Georg Thieme Verlag Stuttgart · New York — Synthesis 2017, 49, 3885–3886
Cobalt in Organic Synthesis
K. Xu S. Zhang
M. Petit
R2R1
R1
BpinBPin
R2
R1
BpinH
R2
B2Pin2
HCo(PMe3)4 5 mol%
HBPin
Take one get one
Take two get two
NH
O
AQ
H
+ Et3Al
Co(acac)3 (5 mol%)1,10-phen (5.5 mol%)
2,3-DCB (120 mol%)THF, 70 °C, 20 h
NH
O
AQ
Et
D. P. Furkert M. A. Brimble
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© Georg Thieme Verlag Stuttgart · New York — Synthesis 2017, 49, 3885–3886
Cover Page Special TopicSyn thesis
E. Balaraman
* Simple & Efficient* Practical condition* Broad substarte scope* Functional group tolerance
CoCl2.6H2O/PPh3NH2
R + R OH
HN
R
R
Readilyavailable
tBuOK+ H2O
J. A. Gladysz
NH2
Co
NH2
NH2
H2N
H2NH2N Ar
Ar
Ar
Ar
Ar
Ar
3+
B. Sundararaju
A. Cabré X. Verdaguer A. Riera
O
RNMO·H2O
O
OR
Co2(CO)6
CH2Cl2, RTHO
OH
P. Knochel
R1 NH
O
N
R3
F R2
J.-L. Niu M.-P. Song
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