Saving Mothers: policy and management guidelines for common ...
CMACE 2006-2008 Saving Mothers' Lives
Transcript of CMACE 2006-2008 Saving Mothers' Lives
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CMACE 2006‐2008
Saving Mothers’Lives
Mark ScruttonConsultant AnaesthetistSt Michael’s HospitalBristol UK
StockholmMay 2011
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History of CEMD
• Series of triennial reports 1952‐present
• 1952‐1984 England & Wales
• 1985‐present UK
• 1 April 2003 CEMD →CEMACH/CEMACE• (January 2009 Ireland (2009‐11))?
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Methodology
• NOT Clinical audit
• ‘observational and self‐reflective study which identifies patterns of practice, service provision and public health issues that may be causally related to maternal deaths.’
• ‘sentinel event reporting’
• Small numbers....
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‘Vignettes’
• Past reports included ‘case examples’
• Problems with patient confidentiality
• 2000‐2002 and thereafter ‘composite vignettes’
• Less helpful?
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Causes of death: definitions
‘Maternal death’ Pregnancy → 42 days post
‘Direct’ Obstetric diseases‘Indirect’ Pre‐existing diseases
‘Coincidental’ (fortuitous)
‘Late’ 42 → I year
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UK Maternal mortality rates 1952‐2008per 100,000 maternities
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UK Maternal death rate 2006‐2008
UK: total reported 11.39/100,000 maternities
UK: Death certificates 6.76/100,000 maternities
UK: WHO definition 6.7/100,000 live births
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UK Maternal death rate 1994‐2008
Years No of deaths Rate
1994‐96 158 7.21997‐99 128 6.02000‐02 136 6.82003‐05 149 7.0
2006‐08 155 6.7
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International comparisons 2010
lower & upper estimates
Sweden 6 (3‐8)UK 7Germany 7 (6‐9)France 8 (5‐14)Canada 12 (7‐20)USA 24 (20‐27)Afghanistan 1400 (750‐2600)
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Top 10 Recommendations
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Top 10 Recommendations 2003‐5
1. Pre‐conception care
2. Easy access3. Seen within 2 weeks4. Immigrant women
5. Treat systolic HT6. Risks of CS & placenta praevia7. Critical incident reporting & learning8. Training for recognising serious illness9. MOEWS10. Guidelines – obesity, sepsis, early pregnancy
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Top 10 Recommendations 2006‐8
1. Pre‐conception counselling
2. Interpretation services3. Communication & referral4. Multidisciplinary specialist care
5. BACK TO BASICS: Clinical skills and training6. Recognising and managing sick women7. Treat systolic HT 8. Sepsis9. Incident reporting
10. Pathology
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The good news: 2006‐8
• Statistically significant decline in mortality in:– Direct deaths
– Thromboembolism
– Black African women
• Halving of deaths from ectopics
• More women attending antenatal clinic
• Reduction in inequalities gap
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The bad news: 2006‐8
• Indirect deaths unchanged
• Sepsis worse
• Substandard care remains
• Back to basics & teamworking
• Communication, referral & involvement
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Causes of death: 2006‐8
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Quality of care: 2006‐8
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Causes of death: 2006‐8
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www.cemach.org.uk
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Sepsis: 26 + 3 Direct deaths
• Strep pyogenes (Gp A Strep) 13• E coli 5• Staph aureus 3• Strep pneumoniae 1• Morganella morganii 1• Clostridium septicum 1• PVL MRSA 1• Unknown 4
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Sepsis: Key points
• Be aware of sepsis – sepsis beware!
• Educate: patients & healthcare providers
• Diagnose & monitor
• IMMEDIATE antibiotics
• Guidelines (Abx & Mx)
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Sepsis: Back to Basics
• Hyper, hypo, swinging pyrexia
• Tachycardia > 100
• Tachypnoea > 20
• Leucopenia < 4 x 109
• Diarrhoea
• Abdo pain
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Sepsis: Key points
Surviving Sepsis Campaign:
International guidelines for management of
severe sepsis and septic shock.
Crit Care Med 2008;36:296‐327
....but careful with fluids
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Thrombosis and thromboembolism
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Thrombosis and thromboembolism
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Pre-eclampsia/eclampsia
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0
2
4
6
8
10
12
14
1985-1987
1988-1990
1991-1993
1994-1996
1997-1999
2000-2002
2003-2005
2006-2008
Cerebral
CEREBRAL deaths in pre-eclampsia/eclampsia
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0
2
4
6
8
10
12
1985-1987
1988-1990
1991-1993
1994-1996
1997-1999
2000-2002
2003-2005
2006-2008
BleedInfarctOedemaEclampsia
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Pre-eclampsia: Hypertension
CEMACE 2006-8
Treat at systolic ≥ 150
CEMACH 2003-5
Treat at systolic ≥ 160(Martin et al, Obstet Gynecol 2005)
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Martin et al, Obstet Gynecol 2005
Mississippi:1980-200328 strokes25 haemorrhagic – data on 24
23/24 systolic > 1603/24 diastolic > 1106/24 MAP > 130
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Top 10 Recommendations
1. Pre‐conception counselling
2. Interpretation services3. Communication & referral4. Multidisciplinary specialist care
5. BACK TO BASICS: Clinical skills and training
6. Recognising and managing sick women
7. Treat systolic HT 8. Sepsis9. Incident reporting
10. Pathology
1. Pre‐conception care
2. Easy access3. Seen within 2 weeks4. Immigrant women5. Treat systolic HT
6. Risks of CS & placentapraevia
7. Critical incident reporting & learning
8. Training for recognising serious illness
9. MOEWS10. Guidelines – obesity, sepsis,
early pregnancy
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Top 10 Recommendations 2006‐8
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Pre-eclampsia: Hypertension
CEMACH 2003-5
Treat at systolic ≥ 160(Martin et al, Obstet Gynecol 2005)
Consider pressor response to intubation
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Pre-eclampsia: Hypertension
CEMACH 2003-5
2 cases:
GA CS for fetal distressBP: 209/120, 210/105
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0
2
4
6
8
10
12
1985-1987
1988-1990
1991-1993
1994-1996
1997-1999
2000-2002
2003-2005
2006-2008
Pulmonary
PULMONARY deaths in pre-eclampsia/eclampsia
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Haemorrhage
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0
5
10
15
20
25
1985-1987
1988-1990
1991-1993
1994-1996
1997-1999
2000-2002
2003-2005
2006-2008
Total
PPH
Abruption
Placenta praevia
Genital tracttrauma
Maternal deaths from haemorrhage
50
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Confidential Enquiries
Recurrent themes:
– Failure to recognise problems
– Failure to take action
– Failure to refer
– Inappropriate delegation to junior staff
– Poor or non-existent teamworking
CEMACH, CESDI & NCEPOD
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Obstetric emergency training
Simulated emergencies should be organised to improve management of rare obstetric emergencies
CESDI – 4th Annual Report 1997CEMD – Why Mothers Die 1998
NHSLA. CNST Maternity Standards 2000CEMACE – Saving Mothers Lives 2007/11
Kings Fund: Safer Births everybody’s business. 2008
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PROMPT: ‘Course in a Box’
• Course manual
• Trainer’s manual
• CD Rom
• Telephone/email support
www.prompt‐course.org
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PROMPT Course
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PPH Drill with props
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EWS/MOEWS
Early warning scores
•Identify serious illness•Trigger referral
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Anaesthesia
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Anaesthetic Related Deaths
• 127 cases (49%) had anaesthetic involvement
• 7 deaths – directly related to the anaesthetic
• 18 deaths – anaesthetic managemtentcontributed to death
• 12 deaths – anaesthetic involvement too late
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Case 1
• Failed intubation
• Oxygenation via iLMA
• Unrecognised oesophageal intubation –increasing hypoxia and no ETCO2
• 2nd dose thiopentone and NDMR given despite coughing
• No cricothyroid access attempted
• Patient had working epidural – not topped up
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Case 1 recommendations
• FAILED INTUBATION DRILLS!!!!!!!!
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Case 1 recommendations
• FAILED INTUBATION DRILLS!!!!!!!!
• Epidural anaesthetic for operative delivery learning point– Top up as soon as decision made for theatre
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PROMPT: Cord Prolapse Drill
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Cord Prolapse
0
5
10
15
20
25
30
Median CP decision‐delivery interval (minutes)
Pre‐Training
Post‐Training
*p<0.0001 (Chi-squared test)
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Neonatal Outcome
0
10
20
30
40
50
Apgar <7 IP Stillbirth NICU Admission
Pre-Training
Post-Training
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Anaesthesia
0
10
20
30
40
50
60
70
80
Epidural GA Spinal
Pre‐Training
Post‐Training
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Case 2
• Occurred on the critical care unit
• Pt with tracheostomy– Difficult tracheostomy
– Removed when pt rolled
• Clear strategy for management of this scenario was needed prior to its occurrence
• Early involvement of more senior staff
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Case 3
• Opioid toxicity in a women with PCA– PCA not available for r/v
• Serious incident learning point– All equipment and drugs retained in situ for inspection and analysis until the cause of the incident is determined
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Case 4
• Acute circulatory failure – ?blood incompatibility after a blood transfusion
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Case 5
• Cardiac arrest during recovery from GA for surgical abortion
• iv syntometrine
• Substance abuse ‐ discovered
75
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Case 6
• Aspirated on emergence from GA for section– Cat 1 section for APH – placenta praevia– Bleeding settled and CVS stable– Not starved– No documentation whether cat 1 required
• Full stomach learning point– Fully awake and protecting airway prior toextubation
– Consider orogastric tube
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Case 7
• Acute haemorrhagic disseminatedleucoencephalitis– Uneventful spinal anaes for caesarean
– Empyema in spinal canal
– Likely trigger for this autoimmune disease
• Need strict asepsis with neuroaxial blocks
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Substandard Care
• 6 out of 7 cases– Not necessarily the cause of death
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Deaths in which Anaesthetic Contributed
• 18 deaths– 10 failure to recognise serious illness
– 8 poor management of pre‐eclampsia/eclampsia
– 6 poor management of sepsis
– 5 poor management of PPH
– 5 poor management of haemorrhage in early pregnancy
– 12 failure to consult with anaes or critical care early
– 9 obesity
– 1 anaphylaxis
– 1 thromboprophylaxis
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Learning Points
• Severe pre‐eclampsia– Immediate treatment and monitoring of BP on HDU
– Early involvement of critical care services
• Sepsis ‐ circulatory collapse– Sudden– Multidisciplinary management– Early abx, fluid resus, +/‐ inotropes, critical care involvement
– Ix – bloods, cultures, lactate– Surgery to remove source
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Learning Points cont.
• Haemorrhage– High risk women – deliver in major obs units with critical care, interventional radiology, cell salvage
– Circulatory collapse can be sudden, MDT management
– Fluids & inotropes– Symptoms/signs harder to recognise
• Language difficulties• Obesity• pre‐eclampsia• Brown/black skin• B‐blockade
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Learning Points cont.
• Anaphylaxis– Management charts should be immediately available
• Co‐morbidities– High risk women require MDT involvement– Deliver in unit available to provide specialist services
• Thromboprophylaxis– Don’t delay 1st dose LMWH
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Anaesthetic deaths: Key points
1. Failed intubation drills
2. Management of severe, acute illnessEarly anaesthetic/critical care involvement
3. Access to critical care services
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Causes of death: 2006‐8
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0
5
10
15
20
25
30
35
1952-54
1955-57
1958-60
1961-63
1964-66
1967-69
1970-72
1973-75
1976-78
1979-81
1982-84
1985-87
1988-90
1991-93
1994-96
1997-99
2000-02
2003-05
2006-08
Congenital
Acquired
per m
illio
n m
ater
nitie
sDeaths from cardiac disease 1964-2008
Yentis
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Cardiac disease
• Pre‐pregnancy counselling
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Pattern of cardiac deaths – UK
0
5
10
15
20
25
30
35
40
45
50
1973-75 1976-78 1979-81 1982-84 1985-87 1988-90 1991-93 1994-96 1997-99 2000-02
Disease arising in pregnancyRisk factorsKnown pre-existing disease
1973-2002
Malhotra S, Yentis SM. IJOA 2006; 15: 223-6Yentis
1973 2002
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Cardiac disease
• Pre‐pregnancy counselling• Investigation & diagnosis• Refer/discuss with specialist centre
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Top 10 Recommendations 2006‐8
1. Pre‐conception counselling
2. Interpretation services3. Communication & referral4. Multidisciplinary specialist care
5. BACK TO BASICS: Clinical skills and training6. Recognising and managing sick women
7. Treat systolic HT 8. Sepsis9. Incident reporting
10. Pathology
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Nothing new?
Do the simple things well
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The future?
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Centre for Maternal and Child EnquiriesImproving the health of mothers, babies and children
12 maternal deaths from swine flu in UK 2009
www.cemach.org.uk
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Saving Mothers' Lives 2009-2011 Report
A report of the UK confidential enquiries into maternal deaths
?www.cemach.org.uk
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The Pyramid of Disease
Deaths
Severe Morbidity
Illness requiringmedical care
Asymptomatic/Self‐care
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UKOSS: Completed Studies
2006• Eclampsia• Peripartum Hysterectomy• Acute Fatty Liver• Antenatal PE• TB
2007• Gastroschisis
2008• Extreme Obesity• FMAIT
2009• Therapies for Peripartum
Haemorrhage• Multiple repeat caesarean
section• Pregnancy in renal transplant
recipients
2010• H1N1v influenza in pregnancy• Antenatal Stroke• Failed Intubation• Malaria• Congenital Diaphragmatic Hernia• Myocardial Infarction• Uterine Rupture
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UKOSS: Current Studies
• Amniotic Fluid Embolism• Aortic dissection• Myeloproliferative disorders• Pituitary tumours in pregnancy• Placenta Accreta• Pulmonary Vascular Disease• Obstetric Cholestasis• Non‐renal Transplant recipients• Sickle cell disease
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http://www.healthcareimprovementscotland.org/home.aspx
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